Drosophila melanogaster

107 known processes

debcl (Dmel_CG33134)

death executioner Bcl-2 homologue

(Aliases: Dbok,dBOK,dBrog-1,Debcl/dBorg-1/dRob-1,Debcl,BOK,Debcl/dBorg-1/dBok/Drob-1,dbok,debok,Bok(Debcl),dborg1,Dmel\CG33134,Debcl/Drob-1/dBorg-1/dBok,dBok,dBorg-1,Drob-1/Debcl/dBorg-1/dBok,Drob-1/Debcl/dBORG-1,Bok,CG12397,dBorg01,debcl/Borg1,Drob-1,CG33134,DBok,Drob-1/Debcl/dBorg-1/DBok,DEBCL,dBorg1,BG1,dBORG-1/DROB-1/DEBCL/dBOK,drob-1,borg1/debcl)

debcl biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
deathGO:00162652840.775
neuron projection guidanceGO:00974852410.775
positive regulation of programmed cell deathGO:0043068620.760
Fly
developmental programmed cell deathGO:00106231380.655
regulation of apoptotic processGO:00429811300.655
ectopic germ cell programmed cell deathGO:003523480.633
chemotaxisGO:00069352490.631
immune system processGO:00023763470.595
vesicle mediated transportGO:00161923810.575
endocytosisGO:00068973100.499
defense responseGO:00069523000.495
epithelial cell developmentGO:00020642740.460
protein modification processGO:00362114380.453
immune responseGO:00069552460.408
positive regulation of cell deathGO:0010942690.395
Fly
cell deathGO:00082192790.350
positive regulation of autophagyGO:0010508210.348
small molecule metabolic processGO:00442813050.347
Worm
regulation of cell deathGO:00109411730.335
regulation of programmed cell deathGO:00430671520.331
chromosome organizationGO:00512763600.316
organophosphate metabolic processGO:00196371950.311
Worm
regulation of innate immune responseGO:0045088710.288
proteolysisGO:00065081920.279
regulation of response to external stimulusGO:00321011150.262
innate immune responseGO:00450871440.259
response to ionizing radiationGO:0010212320.254
defense response to other organismGO:00985422250.248
regulation of proteolysisGO:0030162870.240
eye developmentGO:00016543230.237
response to abiotic stimulusGO:00096283410.233
organonitrogen compound metabolic processGO:19015643180.211
Worm
autophagyGO:00069141080.200
cellular response to dna damage stimulusGO:00069742230.193
eye morphogenesisGO:00485922600.180
positive regulation of macromolecule metabolic processGO:00106044050.178
phosphorylationGO:00163102940.177
regulation of cellular response to stressGO:0080135890.174
cellular response to radiationGO:0071478520.174
compound eye developmentGO:00487493070.162
heart developmentGO:0007507820.161
protein localizationGO:00081042840.160
regulation of immune system processGO:00026821760.158
enzyme linked receptor protein signaling pathwayGO:00071671790.156
axon developmentGO:00615642970.149
regulation of response to stressGO:00801342000.148
neuron deathGO:0070997270.146
regulation of catalytic activityGO:00507901850.144
Worm
response to other organismGO:00517072930.139
central nervous system developmentGO:00074172010.138
response to endogenous stimulusGO:00097191190.136
regulation of anatomical structure morphogenesisGO:00226032420.135
Worm
response to radiationGO:00093141550.135
positive regulation of cellular biosynthetic processGO:00313283160.134
cellular amine metabolic processGO:0044106120.132
response to biotic stimulusGO:00096072940.130
response to bacteriumGO:00096171980.129
gland developmentGO:00487321910.128
dna replicationGO:0006260480.126
cellular lipid metabolic processGO:0044255830.126
phagocytosisGO:00069092150.123
regulation of phosphorylationGO:00423251470.120
axon guidanceGO:00074112330.114
photoreceptor cell differentiationGO:00465301700.112
dna metabolic processGO:00062592270.108
cell cycle arrestGO:000705040.108
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.104
pigment metabolic processGO:0042440840.104
negative regulation of signalingGO:00230572190.104
cell migrationGO:00164772380.104
regulation of endopeptidase activityGO:0052548360.101
regulation of kinase activityGO:0043549530.097
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630110.096
apoptotic processGO:00069151590.095
positive regulation of biosynthetic processGO:00098913160.094
dendrite developmentGO:00163582040.093
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281250.093
positive regulation of catalytic activityGO:00430851180.093
Worm
positive regulation of compound eye retinal cell programmed cell deathGO:004667290.092
positive regulation of retinal cell programmed cell deathGO:004667090.092
positive regulation of apoptotic processGO:0043065470.092
imaginal disc derived wing morphogenesisGO:00074763370.091
positive regulation of apoptotic signaling pathwayGO:200123540.091
cellular macromolecule localizationGO:00707272200.091
stress activated protein kinase signaling cascadeGO:0031098550.089
hemopoiesisGO:0030097460.089
mitochondrion organizationGO:0007005650.088
Worm
positive regulation of response to stimulusGO:00485843230.088
cellular response to organic substanceGO:00713101320.086
response to external biotic stimulusGO:00432072930.085
antimicrobial humoral responseGO:0019730990.084
positive regulation of immune responseGO:0050778630.082
regulation of locomotionGO:0040012420.082
circulatory system developmentGO:0072359820.082
response to organic substanceGO:00100332840.082
protein maturationGO:0051604710.080
cellular response to chemical stimulusGO:00708871990.080
macromolecular complex assemblyGO:00650032560.078
taxisGO:00423303040.077
homeostatic processGO:00425921990.077
programmed cell deathGO:00125012570.075
establishment of localization in cellGO:00516494020.074
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:007005940.074
regulation of cell cycleGO:00517262910.074
regulation of localizationGO:00328792750.073
ovarian follicle cell developmentGO:00307072480.072
nucleobase containing small molecule metabolic processGO:00550861740.072
Worm
regulation of transferase activityGO:0051338580.071
macroautophagyGO:0016236420.071
regulation of intracellular signal transductionGO:19025312360.071
defense response to bacteriumGO:00427421780.070
single organism biosynthetic processGO:00447112060.070
wing disc morphogenesisGO:00074723440.069
positive regulation of cellular amine metabolic processGO:003324000.069
organic substance transportGO:00717022570.068
protein phosphorylationGO:00064681690.067
cellular response to abiotic stimulusGO:0071214580.066
negative regulation of dna replicationGO:000815670.066
regulation of cysteine type endopeptidase activityGO:2000116270.066
eye antennal disc developmentGO:0035214600.065
response to growth factorGO:0070848310.063
regulation of response to extracellular stimulusGO:0032104180.062
amine metabolic processGO:0009308120.062
positive regulation of jun kinase activityGO:004350740.062
regulation of phosphorus metabolic processGO:00511742100.062
Worm
cardiovascular system developmentGO:0072358820.062
regulation of protein metabolic processGO:00512462560.061
cell type specific apoptotic processGO:0097285380.061
appendage morphogenesisGO:00351073970.061
establishment of protein localizationGO:00451841630.060
response to light stimulusGO:00094161240.060
positive regulation of response to external stimulusGO:0032103440.060
response to heatGO:0009408630.059
lipid metabolic processGO:00066291210.059
stress activated mapk cascadeGO:0051403520.059
instar larval developmentGO:0002168550.057
neuron apoptotic processGO:0051402170.056
localization of cellGO:00516742570.056
negative regulation of cell proliferationGO:0008285690.053
negative regulation of apoptotic processGO:0043066630.053
columnar cuboidal epithelial cell developmentGO:00020662490.053
negative regulation of cell cycleGO:00457861160.053
positive regulation of phosphorylationGO:0042327870.053
signal transduction in response to dna damageGO:004277030.052
compound eye photoreceptor cell differentiationGO:00017511400.052
single organism membrane organizationGO:0044802930.052
Worm
regulation of jnk cascadeGO:0046328400.052
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.051
negative regulation of gene expressionGO:00106293870.051
positive regulation of cellular protein metabolic processGO:00322701180.051
cellular protein modification processGO:00064644380.051
positive regulation of phosphorus metabolic processGO:00105621390.050
Worm
anatomical structure homeostasisGO:0060249970.050
defense response to gram negative bacteriumGO:0050829940.050
morphogenesis of an epitheliumGO:00020092760.048
appendage developmentGO:00487364010.048
positive regulation of protein modification processGO:0031401580.048
positive regulation of cysteine type endopeptidase activityGO:2001056240.047
regulation of autophagyGO:0010506620.046
tissue deathGO:00162711020.046
negative regulation of signal transductionGO:00099682060.046
dna biosynthetic processGO:0071897240.045
regulation of multicellular organismal developmentGO:20000264140.045
carboxylic acid metabolic processGO:0019752920.045
response to starvationGO:0042594970.045
positive regulation of immune system processGO:0002684680.044
negative regulation of programmed cell deathGO:0043069720.044
protein processingGO:0016485680.043
immune system developmentGO:0002520570.043
regulation of compound eye retinal cell programmed cell deathGO:0046669180.041
photoreceptor cell developmentGO:0042461960.040
cellular response to starvationGO:0009267610.040
tube developmentGO:00352952440.040
stem cell differentiationGO:00488631170.040
positive regulation of protein metabolic processGO:00512471280.040
response to nutrient levelsGO:00316671140.040
embryonic organ developmentGO:0048568500.039
response to reactive oxygen speciesGO:0000302240.039
positive regulation of mapk cascadeGO:0043410630.038
regulation of peptidase activityGO:0052547390.038
mushroom body developmentGO:0016319700.038
secretion by cellGO:00329401010.037
jnk cascadeGO:0007254500.037
axonogenesisGO:00074092900.037
cellular response to endogenous stimulusGO:0071495800.037
peptide metabolic processGO:0006518800.037
regulation of phosphate metabolic processGO:00192202100.037
Worm
cellular amide metabolic processGO:0043603800.037
regulation of cell cycle processGO:00105641810.036
embryonic morphogenesisGO:00485982060.036
cell recognitionGO:00080371020.036
positive regulation of protein serine threonine kinase activityGO:0071902150.036
regulation of anatomical structure sizeGO:00900661630.036
response to alcoholGO:0097305950.036
response to oxygen containing compoundGO:19017002000.036
chorion containing eggshell formationGO:00073041050.036
dendrite morphogenesisGO:00488131990.036
regulation of immune responseGO:00507761180.035
imaginal disc derived appendage developmentGO:00487373990.035
regulation of cellular localizationGO:00603411360.035
epithelial cell differentiationGO:00308553220.035
cellular amino acid metabolic processGO:0006520610.034
limb developmentGO:006017310.034
single organism catabolic processGO:00447122280.034
ion transportGO:00068111450.034
cellular response to ionizing radiationGO:0071479150.033
multicellular organismal homeostasisGO:0048871410.033
cell motilityGO:00488702510.033
negative regulation of nitrogen compound metabolic processGO:00511722650.033
intracellular signal transductionGO:00355563000.032
glycerophospholipid metabolic processGO:0006650230.032
compound eye morphogenesisGO:00017452490.032
regulation of organ morphogenesisGO:2000027780.032
negative regulation of dna dependent dna replicationGO:200010420.032
regulation of protein transportGO:0051223570.032
positive regulation of protein kinase activityGO:0045860250.031
intrinsic apoptotic signaling pathwayGO:0097193160.031
response to oxidative stressGO:0006979860.031
response to x rayGO:001016580.031
purine nucleoside catabolic processGO:00061521120.031
Worm
glycerolipid metabolic processGO:0046486340.031
regulation of hydrolase activityGO:0051336970.030
Worm
cellular response to gamma radiationGO:0071480100.030
sex differentiationGO:0007548810.030
positive regulation of intracellular signal transductionGO:19025331160.030
embryonic development via the syncytial blastodermGO:00017001480.030
positive regulation of macroautophagyGO:001623980.029
regulation of humoral immune responseGO:0002920510.029
organic acid metabolic processGO:00060821030.029
negative regulation of neuron deathGO:1901215180.029
cell cycle phase transitionGO:00447701400.029
catabolic processGO:00090564090.028
organic hydroxy compound metabolic processGO:1901615830.028
positive regulation of catabolic processGO:00098961050.028
tissue homeostasisGO:0001894360.028
sensory organ morphogenesisGO:00905962600.027
nucleotide excision repairGO:000628980.027
response to temperature stimulusGO:00092661060.027
negative regulation of cellular metabolic processGO:00313243820.027
lipid homeostasisGO:0055088330.027
regulation of protein processingGO:0070613320.027
regulation of neuron deathGO:1901214260.027
hematopoietic or lymphoid organ developmentGO:0048534570.027
purine ribonucleoside metabolic processGO:00461281270.026
Worm
regulation of cellular protein metabolic processGO:00322682430.026
intracellular transportGO:00469072280.026
melanization defense responseGO:0035006450.025
organelle fissionGO:00482853400.025
cell proliferationGO:00082832990.024
positive regulation of cell differentiationGO:0045597640.024
single organism cellular localizationGO:19025801800.024
mitotic sister chromatid segregationGO:0000070870.024
histolysisGO:00075591020.024
eggshell formationGO:00307031050.024
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.024
cellular response to external stimulusGO:0071496660.024
meiotic cell cycle processGO:19030461320.024
regulation of neuron apoptotic processGO:0043523160.023
positive regulation of transferase activityGO:0051347260.023
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280230.023
regulation of mitotic cell cycleGO:00073461900.023
cellular catabolic processGO:00442483720.023
regulation of molecular functionGO:00650092170.022
Worm
cell growthGO:00160491080.022
epithelial cell migrationGO:00106311480.022
macromolecule catabolic processGO:00090571610.022
peptide biosynthetic processGO:0043043420.022
positive regulation of signal transductionGO:00099672230.022
positive regulation of protein phosphorylationGO:0001934340.022
regulation of protein kinase activityGO:0045859510.022
morphogenesis of embryonic epitheliumGO:0016331940.022
regulation of cell developmentGO:00602842150.021
ameboidal type cell migrationGO:00016671510.021
developmental growth involved in morphogenesisGO:0060560650.021
negative regulation of nucleobase containing compound metabolic processGO:00459342610.021
triglyceride metabolic processGO:0006641120.021
negative regulation of proteolysisGO:0045861310.021
reproductive structure developmentGO:0048608740.021
biological adhesionGO:00226101380.021
micropyle formationGO:004684440.021
negative regulation of cell communicationGO:00106482230.020
positive regulation of stem cell differentiationGO:200073830.020
regulation of cellular amine metabolic processGO:003323830.020
glial cell differentiationGO:0010001350.020
anterior midgut ectodermal morphogenesisGO:000744140.020
regulation of transcription from rna polymerase ii promoterGO:00063573780.020
brain developmentGO:00074201200.020
columnar cuboidal epithelial cell differentiationGO:00020652560.020
salivary gland morphogenesisGO:00074351450.019
positive regulation of signalingGO:00230562430.019
negative regulation of epithelial cell proliferationGO:005068040.019
cell agingGO:000756920.019
molting cycle chitin based cuticleGO:0007591560.019
salivary gland cell autophagic cell deathGO:0035071830.018
respiratory system developmentGO:00605412130.018
purine nucleotide metabolic processGO:00061631460.018
Worm
dna dependent dna replicationGO:0006261170.018
male sex differentiationGO:0046661250.018
cation transportGO:00068121100.018
purine containing compound catabolic processGO:00725231120.018
Worm
apoptotic signaling pathwayGO:0097190270.018
regulation of antimicrobial peptide biosynthetic processGO:0002805380.018
cellular response to growth factor stimulusGO:0071363300.017
oxidation reduction processGO:00551141230.017
positive regulation of nucleobase containing compound metabolic processGO:00459353320.017
Worm
protein import into nucleusGO:0006606510.017
locomotory behaviorGO:00076261760.017
nuclear body organizationGO:003057560.017
negative regulation of rna metabolic processGO:00512532510.017
dna damage checkpointGO:0000077780.017
immune response regulating signaling pathwayGO:000276420.017
response to superoxideGO:000030330.017
negative regulation of dna endoreduplicationGO:003287620.017
glycosyl compound metabolic processGO:19016571270.017
Worm
kidney developmentGO:000182230.017
peptidyl amino acid modificationGO:00181931050.017
spermatid developmentGO:0007286980.017
regulation of histone deacetylationGO:003106320.017
regulation of neurogenesisGO:00507671580.016
melanin metabolic processGO:0006582470.016
camera type eye developmentGO:004301040.016
neurological system processGO:00508773580.016
embryonic digestive tract developmentGO:004856650.016
immune effector processGO:0002252980.016
regulation of developmental pigmentationGO:0048070240.016
regulation of macroautophagyGO:0016241150.016
embryo development ending in birth or egg hatchingGO:00097921520.016
Worm
blastoderm segmentationGO:00073501590.016
positive regulation of molecular functionGO:00440931360.016
Worm
positive regulation of nucleic acid templated transcriptionGO:19035082660.016
myotube cell developmentGO:001490430.015
protein modification by small protein conjugation or removalGO:00706471060.015
tissue morphogenesisGO:00487292970.015
histone modificationGO:00165701060.015
negative regulation of cell deathGO:0060548810.015
female genitalia developmentGO:003054060.015
regulation of dna metabolic processGO:0051052340.015
nucleotide metabolic processGO:00091171610.015
Worm
response to hydrogen peroxideGO:0042542110.015
regulation of defense responseGO:00313471020.015
protein dephosphorylationGO:0006470270.015
phospholipid metabolic processGO:0006644230.015
somatic cell dna recombinationGO:001644410.015
positive regulation of cellular component organizationGO:00511301560.014
Worm
retina development in camera type eyeGO:006004140.014
extrinsic apoptotic signaling pathwayGO:009719110.014
negative regulation of defense responseGO:0031348350.014
regulation of protein localizationGO:0032880760.014
eye photoreceptor cell differentiationGO:00017541450.014
protein complex biogenesisGO:00702712010.014
regulation of cell proliferationGO:00421271630.014
oxoacid metabolic processGO:00434361030.014
nitrogen compound transportGO:0071705850.014
gastrulation with mouth forming firstGO:0001703360.014
negative regulation of protein processingGO:0010955310.014
dephosphorylationGO:0016311510.014
response to woundingGO:0009611940.014
regulation of stress activated protein kinase signaling cascadeGO:0070302420.013
autophagic vacuole assemblyGO:000004520.013
response to oxygen radicalGO:000030530.013
digestive tract developmentGO:00485651490.013
dorsal ventral pattern formationGO:00099531330.013
regulation of cell morphogenesis involved in differentiationGO:0010769610.013
negative regulation of catabolic processGO:0009895360.013
nucleoside triphosphate catabolic processGO:00091431080.013
Worm
mitotic cell cycle phase transitionGO:00447721380.013
single organism nuclear importGO:1902593510.013
regulation of protein serine threonine kinase activityGO:0071900250.013
cellular component assembly involved in morphogenesisGO:00109271510.013
defense response to fungusGO:0050832480.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092380.013
gastrulation involving germ band extensionGO:0010004360.013
positive regulation of phosphate metabolic processGO:00459371390.013
Worm
epidermis developmentGO:0008544650.013
positive regulation of transcription dna templatedGO:00458932660.013
cellular response to oxygen containing compoundGO:1901701790.012
regulation of protein maturationGO:1903317320.012
positive regulation of cell developmentGO:0010720610.012
positive regulation of nitrogen compound metabolic processGO:00511733540.012
Worm
cellular component disassemblyGO:0022411460.012
ribonucleoside monophosphate metabolic processGO:0009161510.012
epithelium migrationGO:00901321480.012
gastrulationGO:0007369700.012
gland morphogenesisGO:00226121450.012
positive regulation of defense responseGO:0031349590.012
basement membrane organizationGO:0071711100.012
positive regulation of hydrolase activityGO:0051345780.012
Worm
regulation of protein deacetylationGO:009031120.012
response to ecdysoneGO:0035075340.012
nucleoside phosphate metabolic processGO:00067531620.012
Worm
purine ribonucleoside monophosphate metabolic processGO:0009167500.011
dorsal closureGO:0007391790.011
negative regulation of intracellular signal transductionGO:1902532570.011
ribose phosphate metabolic processGO:00196931450.011
Worm
small gtpase mediated signal transductionGO:0007264880.011
female meiotic divisionGO:0007143700.011
positive regulation of cellular catabolic processGO:0031331950.011
regionalizationGO:00030024160.011
negative regulation of response to stimulusGO:00485852580.011
nuclear importGO:0051170510.011
regulation of retinal cell programmed cell deathGO:0046668180.011
intracellular protein transportGO:00068861040.011
camera type eye morphogenesisGO:004859320.011
protein heterooligomerizationGO:005129140.011
regulation of cell projection organizationGO:0031344920.011
purine nucleoside triphosphate metabolic processGO:00091441190.011
Worm
heart morphogenesisGO:0003007320.011
positive regulation of antimicrobial peptide biosynthetic processGO:0002807260.011
post embryonic appendage morphogenesisGO:00351203850.010
meiotic cell cycleGO:00513211710.010
positive regulation of protein deacetylationGO:009031220.010
germ line stem cell maintenanceGO:0030718500.010
cellular ketone metabolic processGO:0042180240.010
regulation of cell morphogenesisGO:00226041630.010
response to insulinGO:0032868290.010
carboxylic acid transportGO:0046942180.010
positive regulation of neuron apoptotic processGO:004352510.010
response to organic cyclic compoundGO:0014070890.010
response to extracellular stimulusGO:00099911160.010
positive regulation of jnk cascadeGO:0046330160.010
methylationGO:0032259470.010
stem cell maintenanceGO:0019827670.010
response to uvGO:0009411240.010
lipid modificationGO:0030258240.010

debcl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.081
thoracic cancerDOID:509300.081
disease of cellular proliferationDOID:1456600.081
organ system cancerDOID:005068600.081
disease of anatomical entityDOID:700.027
nervous system diseaseDOID:86300.027
musculoskeletal system diseaseDOID:1700.012
breast cancerDOID:161200.012