IMP: Integrative Multi-species Prediction

Drosophila melanogaster

249 known processes

kay (Dmel_CG33956)

kayak

(Aliases: dFRA,Fra,Dfos,c-fos,Fos,AP-1,AP1,dAP-1,dFra,D-fos,DFra,CG33956,dfos,fos,Dmel\CG33956,D-Fos,fbz,dlhD,Kay,D-fos/kay,CG15507,dFos,d-fos,CG15509,DFos,DFOS,c-Fos)

FLYBASE: FBgn0001297
Entrez: 3772082
UniProtKB: C4JC86
UniProtKB: P21525
UniProtKB: A8MPH9

Process Predictions
Disease Predictions

kay biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of cellular biosynthetic process	GO:0031327	277	1.000	Mouse Rat
negative regulation of transcription dna templated	GO:0045892	237	0.998	Mouse Rat
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.998	Mouse Rat
epithelial cell migration	GO:0010631	148	0.998
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.997	Human
negative regulation of rna metabolic process	GO:0051253	251	0.987	Mouse Rat
dendrite development	GO:0016358	204	0.986
negative regulation of rna biosynthetic process	GO:1902679	240	0.986	Mouse Rat
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.985	Mouse Rat
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.982	Human
morphogenesis of an epithelium	GO:0002009	276	0.980
central nervous system development	GO:0007417	201	0.980
dendrite morphogenesis	GO:0048813	199	0.980
regulation of programmed cell death	GO:0043067	152	0.976	Rat
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.973
transcription from rna polymerase ii promoter	GO:0006366	368	0.972
tissue morphogenesis	GO:0048729	297	0.969
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.969
positive regulation of rna metabolic process	GO:0051254	271	0.963
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.957	Human
regulation of phosphate metabolic process	GO:0019220	210	0.956
regulation of intracellular signal transduction	GO:1902531	236	0.951
positive regulation of biosynthetic process	GO:0009891	316	0.942
negative regulation of signal transduction	GO:0009968	206	0.939
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.938	Mouse Rat
regulation of cell death	GO:0010941	173	0.935	Rat
regulation of protein metabolic process	GO:0051246	256	0.927
death	GO:0016265	284	0.926	Rat
negative regulation of cellular metabolic process	GO:0031324	382	0.919	Mouse Rat
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.918	Mouse Rat
positive regulation of signaling	GO:0023056	243	0.912
regulation of apoptotic process	GO:0042981	130	0.896	Rat
synapse organization	GO:0050808	196	0.883
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.878	Mouse Rat
positive regulation of macromolecule metabolic process	GO:0010604	405	0.870
rhythmic process	GO:0048511	106	0.866
regulation of immune system process	GO:0002682	176	0.846	Mouse
apoptotic process	GO:0006915	159	0.843	Rat
negative regulation of cell communication	GO:0010648	223	0.841
regulation of cell differentiation	GO:0045595	302	0.838	Mouse
phosphorylation	GO:0016310	294	0.835
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.831
positive regulation of gene expression	GO:0010628	290	0.824
stem cell differentiation	GO:0048863	117	0.818
regulation of neuromuscular synaptic transmission	GO:1900073	15	0.804
positive regulation of molecular function	GO:0044093	136	0.802	Rat
photoreceptor cell differentiation	GO:0046530	170	0.798
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.794	Mouse Rat
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.786
regulation of protein modification process	GO:0031399	112	0.773
regulation of cell proliferation	GO:0042127	163	0.771	Mouse Rat
micropyle formation	GO:0046844	4	0.771
regulation of protein phosphorylation	GO:0001932	64	0.769
muscle structure development	GO:0061061	224	0.769	Mouse
anterior midgut ectodermal morphogenesis	GO:0007441	4	0.763
embryonic morphogenesis	GO:0048598	206	0.760
negative regulation of intracellular signal transduction	GO:1902532	57	0.760
appendage morphogenesis	GO:0035107	397	0.757
establishment of ommatidial planar polarity	GO:0042067	49	0.757
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.755
circadian rhythm	GO:0007623	105	0.748
regulation of phosphorylation	GO:0042325	147	0.744
activation of protein kinase activity	GO:0032147	12	0.739
regulation of protein kinase activity	GO:0045859	51	0.738
intracellular signal transduction	GO:0035556	300	0.726
cell death	GO:0008219	279	0.720	Rat
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.714
actin filament based process	GO:0030029	220	0.705
positive regulation of cellular biosynthetic process	GO:0031328	316	0.702
regulation of kinase activity	GO:0043549	53	0.696
positive regulation of cellular component organization	GO:0051130	156	0.696	Mouse
mapk cascade	GO:0000165	107	0.687
negative regulation of biosynthetic process	GO:0009890	277	0.686	Mouse Rat
regulation of transferase activity	GO:0051338	58	0.647
response to hydrogen peroxide	GO:0042542	11	0.634	Rat
morphogenesis of embryonic epithelium	GO:0016331	94	0.607
chromatin organization	GO:0006325	207	0.602	Mouse
positive regulation of rna biosynthetic process	GO:1902680	266	0.602
programmed cell death	GO:0012501	257	0.595	Rat
eye morphogenesis	GO:0048592	260	0.593
positive regulation of cell communication	GO:0010647	250	0.566
regulation of dendrite morphogenesis	GO:0048814	28	0.564
sensory organ morphogenesis	GO:0090596	260	0.562
compound eye photoreceptor fate commitment	GO:0001752	36	0.561
photoreceptor cell fate commitment	GO:0046552	41	0.556
bmp signaling pathway	GO:0030509	27	0.556
positive regulation of response to stimulus	GO:0048584	323	0.552
gliogenesis	GO:0042063	80	0.550
embryonic ectodermal digestive tract development	GO:0048611	4	0.544
embryonic development via the syncytial blastoderm	GO:0001700	148	0.544
germ band shortening	GO:0007390	19	0.541
positive regulation of phosphorus metabolic process	GO:0010562	139	0.538
hindgut morphogenesis	GO:0007442	58	0.523
digestive tract morphogenesis	GO:0048546	127	0.517
regulation of localization	GO:0032879	275	0.516
negative regulation of signaling	GO:0023057	219	0.515
growth	GO:0040007	359	0.506
neuron fate commitment	GO:0048663	50	0.499
regulation of transport	GO:0051049	181	0.489
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.485
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.484
negative regulation of cell death	GO:0060548	81	0.478
digestive tract development	GO:0048565	149	0.475
positive regulation of jun kinase activity	GO:0043507	4	0.472
regulation of protein serine threonine kinase activity	GO:0071900	25	0.467
wing disc morphogenesis	GO:0007472	344	0.466
defense response to other organism	GO:0098542	225	0.459
digestive system development	GO:0055123	149	0.457
regulation of molecular function	GO:0065009	217	0.457
brain development	GO:0007420	120	0.454
positive regulation of signal transduction	GO:0009967	223	0.451
genital disc development	GO:0035215	44	0.442
axon development	GO:0061564	297	0.437
macromolecular complex assembly	GO:0065003	256	0.433
regulation of terminal button organization	GO:2000331	11	0.432
regulation of anatomical structure morphogenesis	GO:0022603	242	0.421
embryonic ectodermal digestive tract morphogenesis	GO:0048613	4	0.420
tube development	GO:0035295	244	0.417
regulation of nervous system development	GO:0051960	248	0.415
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.403
positive regulation of protein kinase activity	GO:0045860	25	0.396
larval development	GO:0002164	104	0.396
appendage development	GO:0048736	401	0.395
positive regulation of cellular protein metabolic process	GO:0032270	118	0.394	Mouse
imaginal disc derived appendage development	GO:0048737	399	0.391
negative regulation of response to stimulus	GO:0048585	258	0.388
autophagy	GO:0006914	108	0.380
ectodermal digestive tract morphogenesis	GO:0048567	7	0.378
regulation of cell development	GO:0060284	215	0.376
regulation of phosphorus metabolic process	GO:0051174	210	0.375
negative regulation of gene expression	GO:0010629	387	0.372	Mouse Rat
chemical homeostasis	GO:0048878	92	0.372
negative regulation of cell differentiation	GO:0045596	143	0.366	Mouse
regulation of synapse structure and activity	GO:0050803	128	0.347
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.346
response to axon injury	GO:0048678	12	0.345
axon regeneration	GO:0031103	8	0.344
muscle tissue development	GO:0060537	30	0.341	Mouse
protein localization	GO:0008104	284	0.340
regulation of multicellular organismal development	GO:2000026	414	0.337	Mouse
regulation of mapk cascade	GO:0043408	92	0.334
border follicle cell migration	GO:0007298	113	0.332
ovarian follicle cell development	GO:0030707	248	0.327
positive regulation of phosphate metabolic process	GO:0045937	139	0.325
eye development	GO:0001654	323	0.324
synapse assembly	GO:0007416	143	0.321
cell growth	GO:0016049	108	0.319
muscle system process	GO:0003012	21	0.317
cellular response to oxygen containing compound	GO:1901701	79	0.314	Human
synaptic transmission	GO:0007268	288	0.311
regulation of organelle organization	GO:0033043	196	0.309	Mouse
positive regulation of catalytic activity	GO:0043085	118	0.308
locomotory behavior	GO:0007626	176	0.308
paracrine signaling	GO:0038001	7	0.307
compound eye morphogenesis	GO:0001745	249	0.304
actin cytoskeleton organization	GO:0030036	206	0.303
morphogenesis of a polarized epithelium	GO:0001738	93	0.300
developmental maturation	GO:0021700	172	0.298
response to growth factor	GO:0070848	31	0.296	Human
eye photoreceptor cell fate commitment	GO:0042706	37	0.296
regulation of neurogenesis	GO:0050767	158	0.283
regulation of neuron projection development	GO:0010975	69	0.275
regulation of neurotransmitter levels	GO:0001505	38	0.268
compound eye photoreceptor cell differentiation	GO:0001751	140	0.261
head development	GO:0060322	135	0.256
regulation of neuroblast proliferation	GO:1902692	34	0.255
establishment or maintenance of cell polarity	GO:0007163	167	0.254
immune response	GO:0006955	246	0.254
response to abiotic stimulus	GO:0009628	341	0.251	Rat
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.249
protein complex assembly	GO:0006461	200	0.245
actin filament organization	GO:0007015	126	0.241
positive regulation of phosphorylation	GO:0042327	87	0.240
jak stat cascade	GO:0007259	49	0.235
imaginal disc eversion	GO:0007561	4	0.234
defense response to bacterium	GO:0042742	178	0.233
negative regulation of multicellular organismal process	GO:0051241	142	0.232
positive regulation of programmed cell death	GO:0043068	62	0.229	Rat
hindgut development	GO:0061525	58	0.228
eye photoreceptor cell differentiation	GO:0001754	145	0.212
stress activated mapk cascade	GO:0051403	52	0.212
positive regulation of protein metabolic process	GO:0051247	128	0.210	Mouse
cellular response to abiotic stimulus	GO:0071214	58	0.210
protein phosphorylation	GO:0006468	169	0.210
carbohydrate homeostasis	GO:0033500	12	0.208
signal transduction by phosphorylation	GO:0023014	107	0.207
imaginal disc derived wing morphogenesis	GO:0007476	337	0.204
regulation of cell morphogenesis	GO:0022604	163	0.204
regulation of humoral immune response	GO:0002920	51	0.198
learning or memory	GO:0007611	141	0.198	Rat
negative regulation of apoptotic process	GO:0043066	63	0.197
positive regulation of protein phosphorylation	GO:0001934	34	0.193
glial cell differentiation	GO:0010001	35	0.193
tissue migration	GO:0090130	155	0.191
neuromuscular synaptic transmission	GO:0007274	67	0.189
cellular protein modification process	GO:0006464	438	0.189
heart process	GO:0003015	37	0.189
positive regulation of transferase activity	GO:0051347	26	0.188
multicellular organismal aging	GO:0010259	140	0.186
positive regulation of neurogenesis	GO:0050769	41	0.186
cell cycle g1 s phase transition	GO:0044843	31	0.185
determination of adult lifespan	GO:0008340	137	0.183
negative regulation of cell proliferation	GO:0008285	69	0.181	Rat
regulation of cell shape	GO:0008360	113	0.181
response to oxidative stress	GO:0006979	86	0.178	Human Rat
small gtpase mediated signal transduction	GO:0007264	88	0.173
negative regulation of neuron death	GO:1901215	18	0.170
synaptic growth at neuromuscular junction	GO:0051124	119	0.170
gonad development	GO:0008406	50	0.164
small molecule metabolic process	GO:0044281	305	0.164
taxis	GO:0042330	304	0.163
forebrain development	GO:0030900	2	0.160
chemosensory behavior	GO:0007635	106	0.160
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.160
male gamete generation	GO:0048232	201	0.158
cellular response to endogenous stimulus	GO:0071495	80	0.158	Human Rat
sex differentiation	GO:0007548	81	0.157
tube morphogenesis	GO:0035239	191	0.155
positive regulation of cell differentiation	GO:0045597	64	0.155	Mouse
establishment of localization in cell	GO:0051649	402	0.155
response to oxygen containing compound	GO:1901700	200	0.155	Human Rat
chromosome organization	GO:0051276	360	0.154	Mouse
regulation of cell cycle	GO:0051726	291	0.151
endocytosis	GO:0006897	310	0.150
response to hormone	GO:0009725	45	0.149	Rat
regulation of heart contraction	GO:0008016	21	0.148
immune effector process	GO:0002252	98	0.147
positive regulation of transcription dna templated	GO:0045893	266	0.145
positive regulation of transport	GO:0051050	92	0.145
regionalization	GO:0003002	416	0.144
organophosphate metabolic process	GO:0019637	195	0.143
neuron neuron synaptic transmission	GO:0007270	14	0.143
muscle organ development	GO:0007517	127	0.143	Mouse
negative regulation of immune system process	GO:0002683	50	0.142
compound eye development	GO:0048749	307	0.141
epithelium migration	GO:0090132	148	0.139
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.139
positive regulation of nervous system development	GO:0051962	69	0.138
learning	GO:0007612	75	0.138	Rat
chromatin modification	GO:0016568	147	0.136	Mouse
response to lipopolysaccharide	GO:0032496	4	0.136	Rat
ameboidal type cell migration	GO:0001667	151	0.135
spinal cord development	GO:0021510	1	0.132
oocyte development	GO:0048599	124	0.131
positive regulation of kinase activity	GO:0033674	25	0.129
cellular response to cadmium ion	GO:0071276	6	0.128
columnar cuboidal epithelial cell development	GO:0002066	249	0.127
establishment of planar polarity	GO:0001736	87	0.125
positive regulation of intracellular signal transduction	GO:1902533	116	0.125
negative regulation of developmental process	GO:0051093	201	0.124	Mouse
regulation of catalytic activity	GO:0050790	185	0.124
response to organic substance	GO:0010033	284	0.123	Human Rat
positive regulation of cell proliferation	GO:0008284	47	0.122	Mouse Rat
positive regulation of apoptotic process	GO:0043065	47	0.122	Rat
cellular response to transforming growth factor beta stimulus	GO:0071560	18	0.122	Human
organelle fission	GO:0048285	340	0.121
response to wounding	GO:0009611	94	0.120
gland development	GO:0048732	191	0.119
developmental cell growth	GO:0048588	52	0.119
r7 cell differentiation	GO:0045466	43	0.118
regulation of response to stress	GO:0080134	200	0.117
regulation of epithelial cell proliferation	GO:0050678	4	0.115
mitotic cell cycle phase transition	GO:0044772	138	0.114
response to other organism	GO:0051707	293	0.114
regulation of cellular component biogenesis	GO:0044087	201	0.114
cell proliferation	GO:0008283	299	0.113	Mouse Rat
blood circulation	GO:0008015	26	0.113
positive regulation of pathway restricted smad protein phosphorylation	GO:0010862	1	0.113
embryonic pattern specification	GO:0009880	174	0.112
lipid homeostasis	GO:0055088	33	0.110
chorion containing eggshell formation	GO:0007304	105	0.110
cellular response to inorganic substance	GO:0071241	8	0.110	Mouse
positive regulation of protein modification process	GO:0031401	58	0.108	Mouse
regulation of bmp signaling pathway	GO:0030510	23	0.108
cellular response to chemical stimulus	GO:0070887	199	0.107	Human Mouse Rat
cation transport	GO:0006812	110	0.106
regulation of growth	GO:0040008	233	0.105
reproductive system development	GO:0061458	74	0.105	Mouse
regulation of cellular localization	GO:0060341	136	0.104
positive regulation of developmental process	GO:0051094	143	0.104	Mouse
negative regulation of nervous system development	GO:0051961	92	0.103
negative regulation of mapk cascade	GO:0043409	23	0.100
developmental programmed cell death	GO:0010623	138	0.100
negative regulation of cell cycle	GO:0045786	116	0.100
regulation of cell cycle process	GO:0010564	181	0.099
stress activated protein kinase signaling cascade	GO:0031098	55	0.098
cellular macromolecular complex assembly	GO:0034622	153	0.098
developmental growth	GO:0048589	280	0.098
response to inorganic substance	GO:0010035	44	0.098	Mouse Rat
head involution	GO:0008258	35	0.097
protein transport	GO:0015031	155	0.097
ras protein signal transduction	GO:0007265	88	0.093
positive regulation of neuron differentiation	GO:0045666	26	0.092
protein modification process	GO:0036211	438	0.092
regulation of cellular ketone metabolic process	GO:0010565	3	0.090
regulation of map kinase activity	GO:0043405	17	0.090
regulation of mitotic cell cycle	GO:0007346	190	0.088
regulation of notch signaling pathway	GO:0008593	100	0.087
homeostatic process	GO:0042592	199	0.087
defense response	GO:0006952	300	0.086
positive regulation of cell death	GO:0010942	69	0.086	Rat
response to organonitrogen compound	GO:0010243	75	0.085	Rat
determination of dorsal ventral asymmetry	GO:0048262	3	0.085
positive regulation of mapk cascade	GO:0043410	63	0.085
dna replication	GO:0006260	48	0.084
ion transport	GO:0006811	145	0.082
cellular response to oxidative stress	GO:0034599	28	0.081	Human
urogenital system development	GO:0001655	72	0.081
negative regulation of phosphorus metabolic process	GO:0010563	45	0.081
response to starvation	GO:0042594	97	0.080
reactive oxygen species metabolic process	GO:0072593	22	0.079
humoral immune response	GO:0006959	117	0.079
post embryonic appendage morphogenesis	GO:0035120	385	0.077
negative regulation of protein metabolic process	GO:0051248	85	0.077
response to biotic stimulus	GO:0009607	294	0.077
regulation of cell migration	GO:0030334	22	0.076
mitotic nuclear division	GO:0007067	213	0.076
eggshell chorion assembly	GO:0007306	66	0.076
regulation of cellular protein metabolic process	GO:0032268	243	0.076
regulation of neuron differentiation	GO:0045664	103	0.076
g1 s transition of mitotic cell cycle	GO:0000082	31	0.075
rho protein signal transduction	GO:0007266	14	0.075
cellular catabolic process	GO:0044248	372	0.075
embryonic hindgut morphogenesis	GO:0048619	48	0.074
regulation of multi organism process	GO:0043900	131	0.074
circulatory system process	GO:0003013	37	0.073
oxoacid metabolic process	GO:0043436	103	0.073
axon guidance	GO:0007411	233	0.073
regulation of synapse organization	GO:0050807	110	0.073
immune system process	GO:0002376	347	0.073
regulation of synapse assembly	GO:0051963	94	0.072
lipid localization	GO:0010876	54	0.072
dna integrity checkpoint	GO:0031570	81	0.072
regulation of gliogenesis	GO:0014013	11	0.071
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.071
cellular chemical homeostasis	GO:0055082	40	0.071
response to carbohydrate	GO:0009743	15	0.071
neuron death	GO:0070997	27	0.070
defense response to fungus	GO:0050832	48	0.070
segmentation	GO:0035282	207	0.070
carboxylic acid metabolic process	GO:0019752	92	0.070
hematopoietic progenitor cell differentiation	GO:0002244	1	0.069
heart contraction	GO:0060047	26	0.069
positive regulation of stem cell proliferation	GO:2000648	8	0.069
regulation of response to oxidative stress	GO:1902882	4	0.069
cellular protein complex assembly	GO:0043623	71	0.068
body morphogenesis	GO:0010171	2	0.068
dorsal appendage formation	GO:0046843	47	0.068
germ line stem cell maintenance	GO:0030718	50	0.068
eggshell formation	GO:0030703	105	0.068
cellular amide metabolic process	GO:0043603	80	0.066
response to metal ion	GO:0010038	23	0.066	Mouse
jnk cascade	GO:0007254	50	0.066
regulation of ras protein signal transduction	GO:0046578	93	0.066
positive regulation of immune system process	GO:0002684	68	0.066	Mouse
negative regulation of growth	GO:0045926	84	0.066
neurological system process	GO:0050877	358	0.065	Rat
epithelial cell differentiation	GO:0030855	322	0.065
apoptotic signaling pathway	GO:0097190	27	0.065
cellular component assembly involved in morphogenesis	GO:0010927	151	0.065
oocyte differentiation	GO:0009994	145	0.064
signal transduction in response to dna damage	GO:0042770	3	0.064
negative regulation of autophagy	GO:0010507	16	0.064
regulation of embryonic development	GO:0045995	68	0.063
development of primary sexual characteristics	GO:0045137	50	0.063
collateral sprouting	GO:0048668	3	0.063
regulation of catabolic process	GO:0009894	170	0.063
neuron projection guidance	GO:0097485	241	0.062
activation of jun kinase activity	GO:0007257	3	0.062
regulation of neuron apoptotic process	GO:0043523	16	0.062
regulation of response to biotic stimulus	GO:0002831	63	0.061
regulation of neuron death	GO:1901214	26	0.061
cell cycle phase transition	GO:0044770	140	0.061
response to nitrogen compound	GO:1901698	90	0.061	Rat
aging	GO:0007568	143	0.060	Rat
regulation of glial cell differentiation	GO:0045685	1	0.060
negative regulation of cellular component organization	GO:0051129	108	0.060
peptidyl amino acid modification	GO:0018193	105	0.059
leg disc morphogenesis	GO:0007478	80	0.059
epithelial cell development	GO:0002064	274	0.058
skeletal muscle organ development	GO:0060538	48	0.057	Mouse
wound healing	GO:0042060	75	0.056
g protein coupled receptor signaling pathway	GO:0007186	136	0.055
response to uv	GO:0009411	24	0.055
regulation of vesicle mediated transport	GO:0060627	59	0.055
axis specification	GO:0009798	167	0.055
organonitrogen compound metabolic process	GO:1901564	318	0.055
cellular response to organic substance	GO:0071310	132	0.054	Human Rat
organic substance transport	GO:0071702	257	0.053
regulation of synaptic transmission	GO:0050804	69	0.053
regulation of dendrite development	GO:0050773	37	0.053
positive regulation of hydrolase activity	GO:0051345	78	0.053
regulation of cytoskeleton organization	GO:0051493	89	0.053
protein complex biogenesis	GO:0070271	201	0.053
dorsal closure	GO:0007391	79	0.052
oxidation reduction process	GO:0055114	123	0.052
germ cell migration	GO:0008354	43	0.052
secretion by cell	GO:0032940	101	0.052
cellular amino acid metabolic process	GO:0006520	61	0.052
regulation of developmental growth	GO:0048638	174	0.052
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.052
molting cycle	GO:0042303	56	0.051
reproductive structure development	GO:0048608	74	0.051	Mouse
initiation of dorsal closure	GO:0007392	12	0.050
regulation of actin filament based process	GO:0032970	42	0.050
nucleobase containing small molecule metabolic process	GO:0055086	174	0.050
regulation of cellular amino acid metabolic process	GO:0006521	0	0.050
nucleoside phosphate metabolic process	GO:0006753	162	0.050
regulation of secretion by cell	GO:1903530	39	0.049
negative regulation of hormone biosynthetic process	GO:0032353	1	0.048
imaginal disc derived wing hair site selection	GO:0035320	4	0.048
eye photoreceptor cell development	GO:0042462	81	0.048
positive regulation of peptidase activity	GO:0010952	29	0.048
organophosphate catabolic process	GO:0046434	112	0.047
imaginal disc derived leg morphogenesis	GO:0007480	80	0.047
muscle fiber development	GO:0048747	12	0.047
negative regulation of phosphate metabolic process	GO:0045936	45	0.046
positive regulation of cell development	GO:0010720	61	0.046
single organism behavior	GO:0044708	391	0.045
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.045
striated muscle cell differentiation	GO:0051146	90	0.045
regulation of cell motility	GO:2000145	23	0.045
response to ketone	GO:1901654	34	0.045	Rat
blastoderm segmentation	GO:0007350	159	0.045
regulation of stem cell proliferation	GO:0072091	40	0.045
peptidyl threonine phosphorylation	GO:0018107	2	0.045
glial cell development	GO:0021782	27	0.044
positive regulation of cellular amine metabolic process	GO:0033240	0	0.044
erbb signaling pathway	GO:0038127	58	0.043
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.043
positive regulation of axon extension	GO:0045773	2	0.043
negative regulation of ras protein signal transduction	GO:0046580	13	0.042
axonogenesis	GO:0007409	290	0.042
salivary gland development	GO:0007431	162	0.042
positive regulation of multicellular organismal process	GO:0051240	143	0.042	Mouse
peptide metabolic process	GO:0006518	80	0.042
response to endogenous stimulus	GO:0009719	119	0.042	Human Rat
determination of digestive tract left right asymmetry	GO:0071907	6	0.042
negative regulation of programmed cell death	GO:0043069	72	0.042
hemocyte differentiation	GO:0042386	38	0.042
amine metabolic process	GO:0009308	12	0.041
peptidyl tyrosine modification	GO:0018212	24	0.041
photoreceptor cell development	GO:0042461	96	0.041
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.041
neuroblast proliferation	GO:0007405	74	0.040
maintenance of location	GO:0051235	73	0.040
regulation of nucleotide metabolic process	GO:0006140	62	0.040
dorsal closure elongation of leading edge cells	GO:0007394	10	0.040
regulation of secretion	GO:0051046	44	0.039
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.039
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	4	0.039
negative regulation of mitotic cell cycle	GO:0045930	109	0.038
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.038
regulation of jun kinase activity	GO:0043506	8	0.038
negative regulation of developmental growth	GO:0048640	64	0.038
multi multicellular organism process	GO:0044706	123	0.038	Rat
respiratory system development	GO:0060541	213	0.037
regulation of hemocyte differentiation	GO:0045610	22	0.037
regulation of cellular response to growth factor stimulus	GO:0090287	13	0.037
dorsal ventral pattern formation	GO:0009953	133	0.037
neuron maturation	GO:0042551	31	0.037
response to transforming growth factor beta	GO:0071559	18	0.036	Human
dorsal closure spreading of leading edge cells	GO:0007395	4	0.036
cardiovascular system development	GO:0072358	82	0.036	Mouse
protein targeting to nucleus	GO:0044744	51	0.036
regulation of insulin secretion	GO:0050796	5	0.036
anterior posterior axis specification	GO:0009948	109	0.036
organic acid metabolic process	GO:0006082	103	0.036
negative regulation of molecular function	GO:0044092	51	0.035
neurotransmitter transport	GO:0006836	37	0.035
tracheal outgrowth open tracheal system	GO:0007426	18	0.035
organic hydroxy compound metabolic process	GO:1901615	83	0.035
positive regulation of proteolysis	GO:0045862	52	0.035
regulation of purine nucleotide metabolic process	GO:1900542	62	0.035
pathway restricted smad protein phosphorylation	GO:0060389	1	0.035
embryonic digestive tract development	GO:0048566	5	0.034
purine nucleotide catabolic process	GO:0006195	109	0.034
protein import	GO:0017038	55	0.034
formation of anatomical boundary	GO:0048859	37	0.034
secretion	GO:0046903	109	0.034
imaginal disc fusion	GO:0046528	19	0.034
multicellular organismal reproductive behavior	GO:0033057	110	0.034
negative regulation of cell development	GO:0010721	62	0.033
regulation of cell cycle phase transition	GO:1901987	130	0.033
phagocytosis	GO:0006909	215	0.033
antimicrobial humoral response	GO:0019730	99	0.033
nucleotide catabolic process	GO:0009166	109	0.033
hemocyte migration	GO:0035099	19	0.033
regulation of immune response	GO:0050776	118	0.033
smad protein import into nucleus	GO:0007184	11	0.033
striated muscle tissue development	GO:0014706	27	0.032	Mouse
reproductive behavior	GO:0019098	122	0.032
negative regulation of small gtpase mediated signal transduction	GO:0051058	13	0.032
regulation of cellular amine metabolic process	GO:0033238	3	0.032
negative regulation of cell size	GO:0045792	19	0.032
unidimensional cell growth	GO:0009826	15	0.032

kay disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.133
disease of anatomical entity	DOID:7	0.133
nervous system disease	DOID:863	0.076

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