IMP: Integrative Multi-species Prediction

Drosophila melanogaster

55 known processes

shakB (Dmel_CG34358)

shaking B

(Aliases: CG12678,Pas,CG15451,CG1321,Dmel_CG32508,l(1)R-10-14,l(1)R-10-3,nj-156,pass,R-9-29,l(1)R-10-7,l(1)TH73,Shak B,CG34358,Dmel\CG34358,l(1)19Eb,R9-29,shkB,3,2,6,l(1)R-9-29,l(1)LB21,shak-B,ShakB,shB,pas,nj156,E81,l(1)W3b,Dmel_CG12678,Shak-B,CG32508,W3,l(1)W3)

FLYBASE: FBgn0085387
Entrez: 33062
UniProtKB: P33085
UniProtKB: M9NGR8

Process Predictions
Disease Predictions

shakB biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
single organism behavior	GO:0044708	391	0.967
neurological system process	GO:0050877	358	0.956
detection of stimulus	GO:0051606	156	0.876
locomotory behavior	GO:0007626	176	0.755
adult behavior	GO:0030534	137	0.714
detection of abiotic stimulus	GO:0009582	66	0.665
sensory perception of mechanical stimulus	GO:0050954	72	0.607
detection of external stimulus	GO:0009581	66	0.563
phototransduction	GO:0007602	52	0.549
detection of light stimulus	GO:0009583	58	0.432
ion transmembrane transport	GO:0034220	122	0.419
response to oxygen containing compound	GO:1901700	200	0.328
sensory perception	GO:0007600	196	0.325
divalent inorganic cation transport	GO:0072511	30	0.305
adult locomotory behavior	GO:0008344	76	0.300
detection of visible light	GO:0009584	38	0.283
transmembrane transport	GO:0055085	139	0.230
sensory perception of sound	GO:0007605	56	0.224
response to monosaccharide	GO:0034284	4	0.219
response to radiation	GO:0009314	155	0.217
cell motility	GO:0048870	251	0.183
response to hexose	GO:0009746	3	0.176
sensory perception of chemical stimulus	GO:0007606	116	0.168
response to abiotic stimulus	GO:0009628	341	0.164
cellular response to radiation	GO:0071478	52	0.137
sensory perception of taste	GO:0050909	25	0.137
larval behavior	GO:0030537	42	0.128
response to decreased oxygen levels	GO:0036293	58	0.113
response to glucose	GO:0009749	2	0.109
striated muscle cell differentiation	GO:0051146	90	0.108
eye antennal disc morphogenesis	GO:0007455	34	0.101
cation transmembrane transport	GO:0098655	88	0.096
muscle cell development	GO:0055001	50	0.093
localization of cell	GO:0051674	257	0.090
response to hypoxia	GO:0001666	53	0.081
positive regulation of transport	GO:0051050	92	0.079
divalent metal ion transport	GO:0070838	26	0.077
protein import into nucleus	GO:0006606	51	0.076
post embryonic appendage morphogenesis	GO:0035120	385	0.074
synaptic transmission	GO:0007268	288	0.073
muscle structure development	GO:0061061	224	0.072
homeostatic process	GO:0042592	199	0.072
organic substance transport	GO:0071702	257	0.072
actin filament based process	GO:0030029	220	0.071
intraspecies interaction between organisms	GO:0051703	4	0.070
membrane depolarization	GO:0051899	4	0.067
skeletal muscle organ development	GO:0060538	48	0.063
flight behavior	GO:0007629	26	0.063
response to nutrient levels	GO:0031667	114	0.060
camera type eye development	GO:0043010	4	0.060
actin cytoskeleton organization	GO:0030036	206	0.055
phototransduction visible light	GO:0007603	27	0.055
learning or memory	GO:0007611	141	0.054
ion transport	GO:0006811	145	0.051
response to temperature stimulus	GO:0009266	106	0.050
cell migration	GO:0016477	238	0.050
intracellular signal transduction	GO:0035556	300	0.048
response to pain	GO:0048265	3	0.048
detection of stimulus involved in sensory perception	GO:0050906	92	0.048
regulation of phosphorus metabolic process	GO:0051174	210	0.047
imaginal disc derived wing morphogenesis	GO:0007476	337	0.047
response to organic substance	GO:0010033	284	0.047
positive regulation of biosynthetic process	GO:0009891	316	0.047
myotube cell development	GO:0014904	3	0.046
cellular response to oxygen containing compound	GO:1901701	79	0.046
cellular response to light stimulus	GO:0071482	37	0.045
regulation of multi organism process	GO:0043900	131	0.043	Worm
response to inorganic substance	GO:0010035	44	0.042
inorganic ion transmembrane transport	GO:0098660	73	0.041
response to light stimulus	GO:0009416	124	0.041
negative regulation of multicellular organismal process	GO:0051241	142	0.041	Worm
cognition	GO:0050890	141	0.041
protein modification process	GO:0036211	438	0.041
morphogenesis of an epithelium	GO:0002009	276	0.041	Fly
cytoplasmic transport	GO:0016482	130	0.040
imaginal disc derived appendage development	GO:0048737	399	0.039
cellular protein modification process	GO:0006464	438	0.039
regulation of membrane potential	GO:0042391	35	0.038
striated muscle cell development	GO:0055002	50	0.038
appendage development	GO:0048736	401	0.037
cellular response to monosaccharide stimulus	GO:0071326	2	0.037
organic substance catabolic process	GO:1901575	308	0.036
regulation of cellular localization	GO:0060341	136	0.035
regulation of transport	GO:0051049	181	0.035
neuron recognition	GO:0008038	101	0.035
inorganic cation transmembrane transport	GO:0098662	61	0.034
myofibril assembly	GO:0030239	36	0.034
leg disc development	GO:0035218	92	0.033
cellular response to chemical stimulus	GO:0070887	199	0.032
regulation of cell development	GO:0060284	215	0.032	Worm
intracellular transport	GO:0046907	228	0.032
rhodopsin mediated signaling pathway	GO:0016056	21	0.032
response to endogenous stimulus	GO:0009719	119	0.032
dephosphorylation	GO:0016311	51	0.031
chemical homeostasis	GO:0048878	92	0.031
death	GO:0016265	284	0.030	Worm
appendage morphogenesis	GO:0035107	397	0.030
response to osmotic stress	GO:0006970	14	0.029
positive regulation of cell communication	GO:0010647	250	0.029
muscle organ development	GO:0007517	127	0.028
regulation of protein metabolic process	GO:0051246	256	0.028
response to oxygen levels	GO:0070482	59	0.027
regulation of synaptic transmission	GO:0050804	69	0.027
response to extracellular stimulus	GO:0009991	116	0.027
cell death	GO:0008219	279	0.027	Worm
head development	GO:0060322	135	0.026
wing disc morphogenesis	GO:0007472	344	0.025
protein phosphorylation	GO:0006468	169	0.025
eye antennal disc development	GO:0035214	60	0.025
cellular catabolic process	GO:0044248	372	0.024
anterior posterior pattern specification	GO:0009952	136	0.023
ion homeostasis	GO:0050801	55	0.023
single organism intracellular transport	GO:1902582	207	0.023
histolysis	GO:0007559	102	0.023
sensory perception of sweet taste	GO:0050916	14	0.022
sarcomere organization	GO:0045214	26	0.022
positive regulation of intracellular transport	GO:0032388	42	0.022
gland development	GO:0048732	191	0.022
cation homeostasis	GO:0055080	51	0.022
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.021
regionalization	GO:0003002	416	0.021
negative regulation of response to stimulus	GO:0048585	258	0.021
organelle fission	GO:0048285	340	0.021
regulation of catalytic activity	GO:0050790	185	0.021
protein complex biogenesis	GO:0070271	201	0.021
cellular response to hexose stimulus	GO:0071331	1	0.020
salivary gland morphogenesis	GO:0007435	145	0.020
cellular component assembly involved in morphogenesis	GO:0010927	151	0.020
carbohydrate derivative biosynthetic process	GO:1901137	85	0.020
regulation of localization	GO:0032879	275	0.020
feeding behavior	GO:0007631	50	0.020
retina development in camera type eye	GO:0060041	4	0.020
nucleocytoplasmic transport	GO:0006913	72	0.020
catabolic process	GO:0009056	409	0.020
regulation of response to stress	GO:0080134	200	0.020
ribose phosphate metabolic process	GO:0019693	145	0.020
cellular chemical homeostasis	GO:0055082	40	0.020
negative regulation of cellular protein metabolic process	GO:0032269	85	0.020
regulation of cellular protein metabolic process	GO:0032268	243	0.019
response to ethanol	GO:0045471	59	0.019
cell recognition	GO:0008037	102	0.019
protein complex assembly	GO:0006461	200	0.019
response to alcohol	GO:0097305	95	0.019
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.019
cellular response to abiotic stimulus	GO:0071214	58	0.019
regulation of excitatory postsynaptic membrane potential	GO:0060079	3	0.019
small molecule metabolic process	GO:0044281	305	0.018
apoptotic process	GO:0006915	159	0.018	Worm
pigment granule organization	GO:0048753	12	0.018
regulation of phosphate metabolic process	GO:0019220	210	0.018
gland morphogenesis	GO:0022612	145	0.018
single organism catabolic process	GO:0044712	228	0.018
muscle fiber development	GO:0048747	12	0.018
regulation of intracellular signal transduction	GO:1902531	236	0.018
response to carbohydrate	GO:0009743	15	0.018
cation transport	GO:0006812	110	0.018
single organism cellular localization	GO:1902580	180	0.017
cellular homeostasis	GO:0019725	80	0.017
regulation of cytoplasmic transport	GO:1903649	47	0.017
blastoderm segmentation	GO:0007350	159	0.017
salivary gland development	GO:0007431	162	0.017
regulation of molecular function	GO:0065009	217	0.017
thermotaxis	GO:0043052	16	0.017
negative regulation of developmental process	GO:0051093	201	0.016	Worm
muscle tissue development	GO:0060537	30	0.016
regulation of behavior	GO:0050795	75	0.016
response to nitrogen compound	GO:1901698	90	0.016
positive regulation of cellular biosynthetic process	GO:0031328	316	0.016
release of sequestered calcium ion into cytosol	GO:0051209	1	0.015
regulation of cell death	GO:0010941	173	0.015
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.015
skeletal muscle adaptation	GO:0043501	1	0.015
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.015
cellular macromolecule localization	GO:0070727	220	0.015
protein dephosphorylation	GO:0006470	27	0.015
positive regulation of catabolic process	GO:0009896	105	0.015
purine containing compound metabolic process	GO:0072521	155	0.015
transcription from rna polymerase ii promoter	GO:0006366	368	0.015
blood circulation	GO:0008015	26	0.015
protein targeting to nucleus	GO:0044744	51	0.014
metal ion transport	GO:0030001	74	0.014
respiratory system development	GO:0060541	213	0.014
positive regulation of signaling	GO:0023056	243	0.014
receptor clustering	GO:0043113	3	0.014
regulation of cellular amine metabolic process	GO:0033238	3	0.014
cellular response to carbohydrate stimulus	GO:0071322	4	0.014
aggressive behavior	GO:0002118	63	0.014
body morphogenesis	GO:0010171	2	0.014
negative regulation of gene expression	GO:0010629	387	0.014
response to other organism	GO:0051707	293	0.014
somatic muscle development	GO:0007525	66	0.014
larval somatic muscle development	GO:0007526	19	0.014
cellular cation homeostasis	GO:0030003	38	0.013
organonitrogen compound catabolic process	GO:1901565	128	0.013
nucleobase containing compound catabolic process	GO:0034655	165	0.013
lipid metabolic process	GO:0006629	121	0.013
rna processing	GO:0006396	147	0.013
regulation of transmembrane transporter activity	GO:0022898	6	0.013
protein localization	GO:0008104	284	0.013
regulation of cell differentiation	GO:0045595	302	0.013	Worm
muscle system process	GO:0003012	21	0.013
regulation of ion transport	GO:0043269	39	0.013
regulation of phosphatase activity	GO:0010921	3	0.013
response to drug	GO:0042493	17	0.012
immune system process	GO:0002376	347	0.012
regulation of metal ion transport	GO:0010959	15	0.012
detection of chemical stimulus	GO:0009593	93	0.012
organophosphate metabolic process	GO:0019637	195	0.012
single organism nuclear import	GO:1902593	51	0.012
cellular protein localization	GO:0034613	160	0.012
calcium ion homeostasis	GO:0055074	23	0.012
sensory perception of light stimulus	GO:0050953	12	0.012
regulation of anatomical structure size	GO:0090066	163	0.012
regulation of multicellular organismal development	GO:2000026	414	0.012
cell fate determination	GO:0001709	91	0.012
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.012
tissue morphogenesis	GO:0048729	297	0.012	Fly
larval locomotory behavior	GO:0008345	27	0.012
nucleotide catabolic process	GO:0009166	109	0.012
nucleoside phosphate metabolic process	GO:0006753	162	0.012
organic hydroxy compound metabolic process	GO:1901615	83	0.011
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.011
positive regulation of protein localization to nucleus	GO:1900182	21	0.011
organonitrogen compound biosynthetic process	GO:1901566	117	0.011
regulation of embryonic development	GO:0045995	68	0.011
gliogenesis	GO:0042063	80	0.011
regulation of intracellular transport	GO:0032386	64	0.011
positive regulation of secretion	GO:0051047	22	0.011
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.011
response to organonitrogen compound	GO:0010243	75	0.011
carbohydrate derivative catabolic process	GO:1901136	118	0.011
hair cell differentiation	GO:0035315	47	0.011
positive regulation of intracellular protein transport	GO:0090316	30	0.011
acid secretion	GO:0046717	1	0.011
negative regulation of cellular metabolic process	GO:0031324	382	0.011
phagocytosis	GO:0006909	215	0.010
purine nucleoside metabolic process	GO:0042278	127	0.010
regulation of cell cycle	GO:0051726	291	0.010
nephron epithelium morphogenesis	GO:0072088	3	0.010
smoothened signaling pathway	GO:0007224	49	0.010
actomyosin structure organization	GO:0031032	56	0.010
protein import	GO:0017038	55	0.010
cellular ketone metabolic process	GO:0042180	24	0.010
developmental programmed cell death	GO:0010623	138	0.010
positive regulation of response to stimulus	GO:0048584	323	0.010
behavioral response to ethanol	GO:0048149	49	0.010
programmed cell death	GO:0012501	257	0.010	Worm
ribonucleotide biosynthetic process	GO:0009260	28	0.010
negative regulation of signaling	GO:0023057	219	0.010
axon development	GO:0061564	297	0.010
negative regulation of biosynthetic process	GO:0009890	277	0.010
muscle adaptation	GO:0043500	1	0.010

shakB disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.131
	urinary system disease	DOID:18	0	0.030

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