IMP: Integrative Multi-species Prediction

Drosophila melanogaster

164 known processes

Dl (Dmel_CG3619)

Delta

(Aliases: DL,1423/11,anon-WO0118547.269,1053/14,0926/11,CT12133,1119/09,l(3)92Ab,dmDelta,CG3619,C1,1304/03,1485/04,D,Dmel\CG3619,0495/20,delta,l(3)05151,1440/11,l(3)j8C3,delta D1,E(ls)2)

FLYBASE: FBgn0000463
Entrez: 42313
UniProtKB: P10041
UniProtKB: A4V346

Process Predictions
Disease Predictions

Dl biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
head development	GO:0060322	135	0.999	Zebrafish
regionalization	GO:0003002	416	0.999
stem cell maintenance	GO:0019827	67	0.995
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.986
negative regulation of cell differentiation	GO:0045596	143	0.985
formation of anatomical boundary	GO:0048859	37	0.984
cell fate determination	GO:0001709	91	0.984
compound eye morphogenesis	GO:0001745	249	0.981
negative regulation of developmental process	GO:0051093	201	0.977
pericardium development	GO:0060039	2	0.964	Mouse
skin development	GO:0043588	65	0.964	Mouse
lateral inhibition	GO:0046331	206	0.952
formation of organ boundary	GO:0010160	30	0.929
border follicle cell migration	GO:0007298	113	0.928
regulation of cell differentiation	GO:0045595	302	0.918
compound eye development	GO:0048749	307	0.895
gliogenesis	GO:0042063	80	0.878
stem cell development	GO:0048864	79	0.870
urogenital system development	GO:0001655	72	0.870	Mouse
eye antennal disc development	GO:0035214	60	0.867
germarium derived egg chamber formation	GO:0007293	101	0.865
regulation of cell development	GO:0060284	215	0.864
photoreceptor cell fate commitment	GO:0046552	41	0.842
compound eye photoreceptor cell differentiation	GO:0001751	140	0.824
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.812	Mouse
neuron fate commitment	GO:0048663	50	0.807	Human
dorsal ventral pattern formation	GO:0009953	133	0.798
oocyte construction	GO:0007308	112	0.763
positive regulation of cellular biosynthetic process	GO:0031328	316	0.754	Mouse
axis specification	GO:0009798	167	0.732	Mouse
dendrite regeneration	GO:0031104	2	0.729
photoreceptor cell differentiation	GO:0046530	170	0.703
eye photoreceptor cell differentiation	GO:0001754	145	0.701
second mitotic wave involved in compound eye morphogenesis	GO:0016330	7	0.689
regulation of neurogenesis	GO:0050767	158	0.679
heart development	GO:0007507	82	0.672	Mouse
regulation of epidermal cell differentiation	GO:0045604	3	0.657	Mouse
positive regulation of neural precursor cell proliferation	GO:2000179	8	0.654	Mouse
organ formation	GO:0048645	39	0.653
eye photoreceptor cell fate commitment	GO:0042706	37	0.632
left right axis specification	GO:0070986	1	0.630	Mouse
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	2	0.626
establishment or maintenance of polarity of larval imaginal disc epithelium	GO:0016336	3	0.608
forebrain development	GO:0030900	2	0.608	Zebrafish
oocyte morphogenesis	GO:0048601	3	0.588
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.587
attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation	GO:0051316	1	0.584
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.576
meiotic nuclear envelope disassembly	GO:0051078	2	0.571
negative regulation of neurogenesis	GO:0050768	53	0.567
response to radiation	GO:0009314	155	0.564
germ line stem cell division	GO:0042078	25	0.556
hindgut morphogenesis	GO:0007442	58	0.547
cardioblast cell fate specification	GO:0042685	9	0.539
mushroom body development	GO:0016319	70	0.538
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded	GO:0008070	2	0.536
negative regulation of mitotic anaphase promoting complex activity	GO:0060564	2	0.507
sensory organ boundary specification	GO:0008052	22	0.486
sensory organ morphogenesis	GO:0090596	260	0.478
positive regulation of protein import into nucleus translocation	GO:0033160	2	0.475
embryonic heart tube development	GO:0035050	22	0.466	Mouse
negative regulation of response to stimulus	GO:0048585	258	0.448	Rat Fly
positive regulation of nervous system development	GO:0051962	69	0.444	Rat
imaginal disc pattern formation	GO:0007447	91	0.444
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.441	Mouse
oocyte differentiation	GO:0009994	145	0.433
dorsal closure leading edge cell differentiation	GO:0046663	2	0.430
epithelial cell proliferation	GO:0050673	15	0.418	Zebrafish
oocyte fate commitment	GO:0048600	2	0.410
cell fate commitment involved in pattern specification	GO:0060581	31	0.400	Human
dorsal ventral axis specification	GO:0009950	66	0.400
asymmetric cell division	GO:0008356	37	0.399
establishment of ommatidial planar polarity	GO:0042067	49	0.397
meiotic chromosome movement towards spindle pole	GO:0016344	1	0.381
regulation of centriole replication	GO:0046599	2	0.375
determination of left right symmetry	GO:0007368	9	0.360	Zebrafish Mouse
oocyte axis specification	GO:0007309	108	0.357
positive regulation of transcription involved in g2 m transition of mitotic cell cycle	GO:0090282	1	0.350
negative regulation of terminal cell fate specification open tracheal system	GO:0035155	2	0.339
juvenile hormone mediated signaling pathway	GO:0035626	3	0.321
dna templated transcriptional start site selection	GO:0001173	1	0.321
regulation of cell fate specification	GO:0042659	27	0.316
meiotic spindle checkpoint	GO:0044779	1	0.313
negative regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator	GO:1902166	1	0.306
pericardium morphogenesis	GO:0003344	2	0.299	Mouse
negative regulation of transcription initiation from rna polymerase ii promoter	GO:0060633	1	0.296
regulation of nervous system development	GO:0051960	248	0.294
regulation of ran gtpase activity	GO:0032316	1	0.292
eye photoreceptor cell development	GO:0042462	81	0.286
positive regulation of ribosome biogenesis	GO:0090070	3	0.285
negative regulation of dna templated transcription initiation	GO:2000143	1	0.281
segmentation	GO:0035282	207	0.280
oocyte development	GO:0048599	124	0.275
specification of segmental identity antennal segment	GO:0007383	2	0.271
germ line stem cell maintenance	GO:0030718	50	0.265
negative regulation of mrna 3 end processing	GO:0031441	3	0.263
regulation of heart morphogenesis	GO:2000826	3	0.259
regulation of epithelial cell differentiation	GO:0030856	4	0.254	Mouse
eye morphogenesis	GO:0048592	260	0.254
maintenance of chromatin silencing	GO:0006344	0	0.250
ovulation cycle	GO:0042698	1	0.247
negative regulation of transcription from rna polymerase iii promoter	GO:0016480	2	0.241
r3 r4 cell fate commitment	GO:0007464	10	0.240
nurse cell nucleus anchoring	GO:0007302	1	0.235
cell fate specification	GO:0001708	71	0.233
negative regulation of epithelial cell migration	GO:0010633	1	0.233	Human Zebrafish Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.233
embryonic hindgut morphogenesis	GO:0048619	48	0.229
heart induction	GO:0003129	3	0.225
p granule organization	GO:0030719	4	0.221
negative regulation of signaling	GO:0023057	219	0.217	Rat Fly
regulation of neuron differentiation	GO:0045664	103	0.216	Mouse
columnar cuboidal epithelial cell development	GO:0002066	249	0.214
regulation of meiotic cell cycle phase transition	GO:1901993	1	0.214
male germline ring canal formation	GO:0030726	3	0.211
meiotic dna repair synthesis	GO:0000711	3	0.211
positive regulation of epithelial cell differentiation	GO:0030858	1	0.208
peptidyl tyrosine modification	GO:0018212	24	0.205
regulation of cardioblast cell fate specification	GO:0042686	8	0.204
negative regulation of nurse cell apoptotic process	GO:0045849	2	0.199
dna integration	GO:0015074	1	0.194
negative regulation of ras gtpase activity	GO:0034261	1	0.191
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0017055	1	0.190
glycosyl compound catabolic process	GO:1901658	112	0.189
release of cytoplasmic sequestered nf kappab	GO:0008588	1	0.189
positive regulation of cell maturation	GO:1903431	2	0.189
asymmetric neuroblast division resulting in ganglion mother cell formation	GO:0055060	2	0.189
female sex determination	GO:0030237	3	0.187
developmental growth involved in morphogenesis	GO:0060560	65	0.186
negative regulation of mrna polyadenylation	GO:1900364	2	0.184
cell morphogenesis involved in malpighian tubule morphogenesis	GO:0061336	1	0.180
positive regulation of chromatin silencing at telomere	GO:0031940	2	0.179
stress granule disassembly	GO:0035617	1	0.179
regulation of transcription involved in g2 m transition of mitotic cell cycle	GO:0000117	1	0.177
protein localization to nucleus	GO:0034504	55	0.176
negative regulation of apoptotic process	GO:0043066	63	0.176
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.175	Mouse
regulation of hematopoietic stem cell differentiation	GO:1902036	1	0.175
maintenance of sister chromatid cohesion	GO:0034086	1	0.168
regulation of transcription from rna polymerase ii promoter mitotic	GO:0046021	2	0.166
negative regulation of cellular metabolic process	GO:0031324	382	0.165	Mouse
germarium derived cystoblast division	GO:0048142	3	0.164
microtubule sliding	GO:0051012	3	0.164
oocyte localization involved in germarium derived egg chamber formation	GO:0030720	12	0.163
stem cell differentiation	GO:0048863	117	0.159
gastrulation	GO:0007369	70	0.157
regulation of epithelial cell proliferation	GO:0050678	4	0.153
establishment or maintenance of cell polarity	GO:0007163	167	0.153
regulation of trichome morphogenesis	GO:2000039	3	0.152
regulation of programmed cell death	GO:0043067	152	0.152
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycle	GO:0051436	2	0.152
regulation of spindle checkpoint	GO:0090231	2	0.148
positive regulation of pole plasm oskar mrna localization	GO:0045856	2	0.148
nucleotide catabolic process	GO:0009166	109	0.145
negative regulation of multicellular organismal process	GO:0051241	142	0.142
negative regulation of cellular catabolic process	GO:0031330	34	0.141
regulation of preblastoderm mitotic cell cycle	GO:0007347	1	0.141
centripetally migrating follicle cell migration	GO:0060269	1	0.141
crystal cell differentiation	GO:0042688	7	0.139	Fly
ganglion mother cell fate determination	GO:0007402	2	0.139
regulation of chromosome condensation	GO:0060623	1	0.133
response to uv b	GO:0010224	1	0.132
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.132
actin filament based process	GO:0030029	220	0.131
magnesium ion homeostasis	GO:0010960	1	0.131
trichome morphogenesis	GO:0010090	3	0.130
metaphase anaphase transition of meiotic cell cycle	GO:0044785	1	0.127
regulation of apoptotic process	GO:0042981	130	0.127
cytoplasmic sequestering of nf kappab	GO:0007253	1	0.127
positive regulation of rna metabolic process	GO:0051254	271	0.126	Mouse
regulation of compound eye photoreceptor development	GO:0045314	12	0.126
regulation of mitotic centrosome separation	GO:0046602	3	0.125
cell division	GO:0051301	248	0.124
establishment of localization in cell	GO:0051649	402	0.124
oocyte nucleus migration involved in oocyte dorsal ventral axis specification	GO:0007312	4	0.121
cell proliferation	GO:0008283	299	0.120
regulation of metaphase anaphase transition of meiotic cell cycle	GO:1902102	1	0.120
cell motility	GO:0048870	251	0.119
regulation of cell proliferation	GO:0042127	163	0.118
male germ cell proliferation	GO:0002176	1	0.118
dorsal vessel heart proper cell fate commitment	GO:0035053	2	0.117
trichome differentiation	GO:0010026	3	0.116
organ induction	GO:0001759	3	0.116
appendage development	GO:0048736	401	0.115
promoter clearance from rna polymerase ii promoter	GO:0001111	1	0.115
regulation of phosphoprotein phosphatase activity	GO:0043666	3	0.114
prostaglandin biosynthetic process	GO:0001516	1	0.109
r7 cell differentiation	GO:0045466	43	0.109
synaptic vesicle budding from presynaptic membrane	GO:0016185	1	0.108
sensory organ precursor cell fate determination	GO:0016360	19	0.106
cell cell junction maintenance	GO:0045217	1	0.106
positive regulation of neurogenesis	GO:0050769	41	0.104	Rat
cytokinesis completion of separation	GO:0007109	1	0.103
response to red light	GO:0010114	2	0.103
response to light stimulus	GO:0009416	124	0.102
cell maturation	GO:0048469	144	0.101
anterior posterior axis specification follicular epithelium	GO:0030714	2	0.101
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO:1902254	1	0.100
meiotic sister chromatid cohesion centromeric	GO:0051754	2	0.099
anterior region determination	GO:0007355	1	0.099
ribonucleoside metabolic process	GO:0009119	127	0.099
histone mrna catabolic process	GO:0071044	0	0.098
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.098	Zebrafish
leg disc development	GO:0035218	92	0.098
nuclear axial expansion	GO:0035191	3	0.096
brain development	GO:0007420	120	0.095	Zebrafish
post embryonic appendage morphogenesis	GO:0035120	385	0.095
response to growth factor	GO:0070848	31	0.094	Human Zebrafish
negative regulation of pigment cell differentiation	GO:0050941	1	0.094
peptidyl arginine omega n methylation	GO:0035247	4	0.094
regulation of presynaptic membrane organization	GO:1901629	1	0.094
digestive tract morphogenesis	GO:0048546	127	0.093	Zebrafish
epithelial cell differentiation	GO:0030855	322	0.093
positive regulation of protein modification process	GO:0031401	58	0.092
small gtpase mediated signal transduction	GO:0007264	88	0.092
negative regulation of phosphatase activity	GO:0010923	3	0.092
apoptotic process	GO:0006915	159	0.091
positive regulation of cyclin catabolic process	GO:2000600	2	0.091
negative regulation of cell development	GO:0010721	62	0.091
genital disc sexually dimorphic development	GO:0035263	4	0.091
establishment of epithelial cell polarity	GO:0090162	13	0.090
negative regulation of metaphase anaphase transition of meiotic cell cycle	GO:1902103	1	0.090
transposon integration	GO:0070893	1	0.090
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.089
regulation of cyclin catabolic process	GO:2000598	2	0.089
hematopoietic stem cell differentiation	GO:0060218	1	0.088	Zebrafish
histone h3 k4 demethylation	GO:0034720	3	0.088
regulation of cohesin localization to chromatin	GO:0071922	2	0.087
notch signaling pathway	GO:0007219	120	0.087
r3 r4 cell differentiation	GO:0048056	12	0.087
morphogenesis of an epithelium	GO:0002009	276	0.086	Zebrafish Mouse
negative regulation of sister chromatid cohesion	GO:0045875	1	0.085
positive regulation of stem cell proliferation	GO:2000648	8	0.085
regulation of organ formation	GO:0003156	3	0.085
negative regulation of gene silencing by mirna	GO:0060965	2	0.085
negative regulation of activin receptor signaling pathway	GO:0032926	1	0.085
positive regulation of ran gtpase activity	GO:0032853	1	0.084
stem cell proliferation	GO:0072089	88	0.081
hindgut development	GO:0061525	58	0.081
purine ribonucleoside catabolic process	GO:0046130	112	0.080
regulation of mrna polyadenylation	GO:1900363	2	0.080
detection of mechanical stimulus involved in sensory perception of touch	GO:0050976	2	0.079
histone h4 acetylation involved in response to dna damage stimulus	GO:2000776	1	0.078
cell migration	GO:0016477	238	0.078
mrna cleavage	GO:0006379	2	0.077
conversion of ds sirna to ss sirna involved in rna interference	GO:0033168	1	0.077
cuticle hydrocarbon biosynthetic process	GO:0006723	2	0.076
ribonucleoprotein complex disassembly	GO:0032988	1	0.076
regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO:1902253	1	0.076
peptidyl serine modification	GO:0018209	7	0.076
transcriptional start site selection at rna polymerase ii promoter	GO:0001174	1	0.075
sex specific pigmentation	GO:0048071	1	0.075
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.075
regulation of cell cell adhesion mediated by cadherin	GO:2000047	1	0.074
negative regulation of programmed cell death	GO:0043069	72	0.074
anterior head segmentation	GO:0035288	3	0.073
regulation of eye photoreceptor cell development	GO:0042478	13	0.073
cenp a containing chromatin organization	GO:0061641	3	0.072
negative regulation of meiotic cell cycle phase transition	GO:1901994	1	0.071
positive regulation of stem cell maintenance	GO:1902459	1	0.071
regulation of wnt signaling pathway	GO:0030111	68	0.071
activation of ral gtpase activity	GO:0032859	1	0.071
myosin ii filament assembly	GO:0031036	1	0.069
eye antennal disc morphogenesis	GO:0007455	34	0.069
icosanoid biosynthetic process	GO:0046456	1	0.068
regulation of histone h4 acetylation involved in response to dna damage stimulus	GO:2000873	1	0.068
compound eye photoreceptor fate commitment	GO:0001752	36	0.068
regulation of heterotypic cell cell adhesion	GO:0034114	1	0.068
postsynaptic density organization	GO:0097106	1	0.068
meiotic spindle assembly checkpoint	GO:0033316	1	0.067
calcium independent cell cell adhesion via plasma membrane cell adhesion molecules	GO:0016338	1	0.067
organic substance transport	GO:0071702	257	0.067
renal tubule development	GO:0061326	64	0.067	Mouse
positive regulation of store operated calcium channel activity	GO:1901341	1	0.066
regulation of cell cycle checkpoint	GO:1901976	2	0.065
regulation of cell death	GO:0010941	173	0.065
peripheral nervous system development	GO:0007422	52	0.065
regulation of notch signaling pathway	GO:0008593	100	0.065	Zebrafish Mouse Rat Fly
respiratory system development	GO:0060541	213	0.064
microtubule cytoskeleton organization involved in establishment of planar polarity	GO:0090176	3	0.064
cenp a containing nucleosome assembly	GO:0034080	3	0.064
synapse assembly involved in innervation	GO:0060386	1	0.064
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.063
external genitalia morphogenesis	GO:0035261	1	0.063
positive regulation of transposition	GO:0010530	1	0.063
border follicle cell delamination	GO:0030709	3	0.062
neural precursor cell proliferation	GO:0061351	75	0.062	Mouse
regulation of spindle assembly involved in mitosis	GO:1901673	3	0.061
suture of dorsal opening	GO:0007396	1	0.061
regulation of compound eye retinal cell apoptotic process	GO:1901692	2	0.060
astral microtubule nucleation	GO:0030954	2	0.060
regulation of molecular function	GO:0065009	217	0.059
regulation of protein modification process	GO:0031399	112	0.059
compound eye retinal cell apoptotic process	GO:1990010	2	0.058
regulation of production of small rna involved in gene silencing by rna	GO:0070920	3	0.058
subsynaptic reticulum organization	GO:1990255	2	0.058
imaginal disc derived appendage development	GO:0048737	399	0.058
cytoskeleton dependent cytoplasmic transport nurse cell to oocyte	GO:0019749	2	0.058
negative regulation of signal transduction by p53 class mediator	GO:1901797	1	0.058
positive regulation of ral gtpase activity	GO:0032852	1	0.057
positive regulation of muscle organ development	GO:0048636	6	0.057
protein localization to nuclear envelope	GO:0090435	2	0.057
central nervous system development	GO:0007417	201	0.057	Human Zebrafish Rat
regulation of transport	GO:0051049	181	0.057
stem cell division	GO:0017145	69	0.057
regulation of centriole centriole cohesion	GO:0030997	1	0.057
meiotic recombination checkpoint	GO:0051598	1	0.056
cell surface receptor signaling pathway involved in heart development	GO:0061311	3	0.056	Mouse
negative regulation of cardioblast differentiation	GO:0051892	7	0.056
dsdna loop formation	GO:0090579	2	0.055
cardiac cell fate specification	GO:0060912	10	0.055
actin filament organization	GO:0007015	126	0.055
positive regulation of golgi to plasma membrane protein transport	GO:0042998	2	0.055
positive regulation of microtubule nucleation	GO:0090063	1	0.054
positive regulation of apoptotic process involved in morphogenesis	GO:1902339	2	0.053
positive regulation of microtubule depolymerization	GO:0031117	2	0.053
wnt signaling pathway involved in heart development	GO:0003306	3	0.052
positive regulation of eye pigmentation	GO:0048075	2	0.052
histone h3 k36 methylation	GO:0010452	1	0.051
sister chromatid biorientation	GO:0031134	1	0.051
positive regulation of eye photoreceptor cell development	GO:0042479	2	0.051
positive regulation of cytoplasmic mrna processing body assembly	GO:0010606	1	0.051
mitotic nuclear envelope reassembly	GO:0007084	1	0.051
dna methylation on cytosine	GO:0032776	1	0.051
autophagic vacuole maturation	GO:0097352	2	0.051
haltere disc morphogenesis	GO:0007481	1	0.051
positive regulation of stem cell differentiation	GO:2000738	3	0.051
hair cell differentiation	GO:0035315	47	0.051	Mouse
fatty acid derivative biosynthetic process	GO:1901570	1	0.051
retinal cell apoptotic process	GO:1990009	2	0.050
eye development	GO:0001654	323	0.050
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.049
maintenance of neuroblast polarity	GO:0045201	3	0.049
septin cytoskeleton organization	GO:0032185	1	0.049
spindle assembly involved in female meiosis ii	GO:0007058	4	0.049
microvillar actin bundle assembly	GO:0030034	1	0.048
imaginal disc derived wing morphogenesis	GO:0007476	337	0.047
regulation of cytokinesis actomyosin contractile ring assembly	GO:2000431	2	0.047
mesodermal cell fate specification	GO:0007501	2	0.047
positive regulation of developmental process	GO:0051094	143	0.047	Rat
regulation of cytoplasmic mrna processing body assembly	GO:0010603	4	0.047
positive regulation of compound eye retinal cell apoptotic process	GO:1901694	1	0.047
nucleotide excision repair dna damage recognition	GO:0000715	0	0.046
female pronucleus assembly	GO:0035038	2	0.046
regulation of shoot system development	GO:0048831	3	0.046
regulation of glial cell differentiation	GO:0045685	1	0.046	Rat
sirna loading onto risc involved in rna interference	GO:0035087	4	0.046
axon development	GO:0061564	297	0.045
membrane addition at site of cytokinesis	GO:0007107	1	0.045
myosin ii filament organization	GO:0031038	1	0.045
regulation of synaptic vesicle clustering	GO:2000807	1	0.045
imaginal disc lineage restriction	GO:0035161	2	0.045
embryonic organ development	GO:0048568	50	0.045	Zebrafish Mouse
histone h4 r3 methylation	GO:0043985	1	0.044
maintenance of polarity of follicular epithelium	GO:0042248	2	0.044
low density lipoprotein receptor particle metabolic process	GO:0032799	1	0.044
positive regulation of cellular response to x ray	GO:2000685	2	0.044
promoter clearance during dna templated transcription	GO:0001109	1	0.044
regulation of transcription from rna polymerase ii promoter in response to stress	GO:0043618	2	0.043
lipoprotein catabolic process	GO:0042159	2	0.043
glial cell development	GO:0021782	27	0.043
positive regulation of posttranscriptional gene silencing	GO:0060148	5	0.043
larval wandering behavior	GO:0035180	2	0.043
peptide cross linking	GO:0018149	2	0.042
telencephalon development	GO:0021537	2	0.042
leaf development	GO:0048366	3	0.042
epithelial tube morphogenesis	GO:0060562	88	0.042	Zebrafish Mouse
muscle cell development	GO:0055001	50	0.042
maintenance of mitotic sister chromatid cohesion	GO:0034088	1	0.042
cytoskeletal anchoring at plasma membrane	GO:0007016	1	0.042
cell fate determination involved in pattern specification	GO:0060582	19	0.041
negative regulation of mrna metabolic process	GO:1903312	5	0.041
compound eye photoreceptor development	GO:0042051	78	0.041
regulation of ran protein signal transduction	GO:0032015	1	0.041
organelle inheritance	GO:0048308	2	0.040
regulation of protein catabolic process	GO:0042176	55	0.039
regulation of ral protein signal transduction	GO:0032485	1	0.039
chromatin remodeling at centromere	GO:0031055	3	0.039
negative regulation of rho gtpase activity	GO:0034259	1	0.039

Dl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
organ system benign neoplasm	DOID:0060085	0.279
pilomatrixoma	DOID:5374	0.279
hair follicle neoplasm	DOID:5375	0.279
benign neoplasm	DOID:0060072	0.279
disease of cellular proliferation	DOID:14566	0.279
skin benign neoplasm	DOID:3165	0.279
integumentary system benign neoplasm	DOID:0060121	0.279
familial meningioma	DOID:4586	0.266
nervous system cancer	DOID:3093	0.266
central nervous system cancer	DOID:3620	0.266
cancer	DOID:162	0.266
organ system cancer	DOID:0050686	0.266
meningioma	DOID:3565	0.266
artery disease	DOID:0050828	0.231
disease of anatomical entity	DOID:7	0.231	Human
vascular disease	DOID:178	0.231
cardiovascular system disease	DOID:1287	0.231
aortic disease	DOID:520	0.231
hajdu cheney syndrome	DOID:2736	0.211
urinary bladder cancer	DOID:11054	0.191
urinary system cancer	DOID:3996	0.191
costello syndrome	DOID:0050469	0.189
leopard syndrome	DOID:14291	0.189
gastrointestinal system cancer	DOID:3119	0.186
liver cancer	DOID:3571	0.186
pancreatic carcinoma	DOID:4905	0.182
endocrine gland cancer	DOID:170	0.182
pancreatic cancer	DOID:1793	0.182
disease of metabolism	DOID:0014667	0.181
hemochromatosis	DOID:2352	0.181
inherited metabolic disorder	DOID:655	0.181
metal metabolism disorder	DOID:896	0.181
nervous system benign neoplasm	DOID:0060115	0.157
aortic valve stenosis	DOID:1712	0.154
heart disease	DOID:114	0.154
heart valve disease	DOID:4079	0.154
aortic valve disease	DOID:62	0.154
myopathy	DOID:423	0.140
muscular disease	DOID:0080000	0.140
cardiomyopathy	DOID:0050700	0.140
intrinsic cardiomyopathy	DOID:0060036	0.140
arrhythmogenic right ventricular cardiomyopathy	DOID:0050431	0.140
musculoskeletal system disease	DOID:17	0.140	Human
muscle tissue disease	DOID:66	0.140
hepatobiliary disease	DOID:3118	0.135
gastrointestinal system disease	DOID:77	0.135
liver disease	DOID:409	0.135
alagille syndrome	DOID:9245	0.135
aortic aneurysm	DOID:3627	0.114
neuroma	DOID:2001	0.112
head and neck squamous cell carcinoma	DOID:5520	0.110
head and neck carcinoma	DOID:1542	0.110
head and neck cancer	DOID:11934	0.110
thyroid cancer	DOID:1781	0.108
myeloma	DOID:0070004	0.100
hemorrhagic thrombocythemia	DOID:2224	0.100
chronic myeloproliferative disease	DOID:2226	0.100
immune system cancer	DOID:0060083	0.100
hematologic cancer	DOID:2531	0.100
bone marrow cancer	DOID:4960	0.100
female reproductive system disease	DOID:229	0.099
ovarian disease	DOID:1100	0.099
reproductive system disease	DOID:15	0.099
premature ovarian failure	DOID:5426	0.099
muscular dystrophy	DOID:9884	0.098
emery dreifuss muscular dystrophy	DOID:11726	0.098
neurilemmoma	DOID:3192	0.093
neurilemmomatosis	DOID:3204	0.093
non syndromic intellectual disability	DOID:0050889	0.088
disease of mental health	DOID:150	0.088
developmental disorder of mental health	DOID:0060037	0.088
specific developmental disorder	DOID:0060038	0.088
non specific x linked mental retardation	DOID:0050776	0.088
intellectual disability	DOID:1059	0.088
proteus syndrome	DOID:13482	0.084
physical disorder	DOID:0080015	0.084
musculoskeletal system cancer	DOID:0060100	0.078
connective tissue cancer	DOID:201	0.078
bone cancer	DOID:184	0.078
integumentary system cancer	DOID:0060122	0.077
fibrodysplasia ossificans progressiva	DOID:13374	0.075
connective tissue disease	DOID:65	0.075	Human
brain cancer	DOID:1319	0.070
leukocyte adhesion deficiency	DOID:6612	0.070
bannayan riley ruvalcaba syndrome	DOID:0050657	0.065
hereditary hemorrhagic telangiectasia	DOID:1270	0.064
thoracic aortic aneurysm	DOID:14004	0.060
sleep disorder	DOID:535	0.056
advanced sleep phase syndrome	DOID:0050628	0.056
reproductive organ cancer	DOID:193	0.055
female reproductive organ cancer	DOID:120	0.055
uterine cancer	DOID:363	0.055
endometrial cancer	DOID:1380	0.055
juvenile polyposis syndrome	DOID:0050787	0.054
li fraumeni syndrome	DOID:3012	0.053
weaver syndrome	DOID:14731	0.048
skin melanoma	DOID:8923	0.048
skin cancer	DOID:4159	0.048
motor neuron disease	DOID:231	0.047
amyotrophic lateral sclerosis type 19	DOID:0060210	0.047
central nervous system disease	DOID:331	0.047
amyotrophic lateral sclerosis	DOID:332	0.047
neurodegenerative disease	DOID:1289	0.047
nervous system disease	DOID:863	0.047
myelofibrosis	DOID:4971	0.046
cell type cancer	DOID:0050687	0.045
melanoma	DOID:1909	0.045
greig cephalopolysyndactyly syndrome	DOID:14761	0.043
bone development disease	DOID:0080006	0.043	Human
bone disease	DOID:0080001	0.043	Human
acrocephalosyndactylia	DOID:12960	0.043
dysostosis	DOID:1934	0.043	Human
synostosis	DOID:11971	0.043
lymphoma	DOID:0060058	0.042
tuberous sclerosis	DOID:13515	0.039

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