IMP: Integrative Multi-species Prediction

Drosophila melanogaster

113 known processes

CDC45L (Dmel_CG3658)

CG3658 gene product from transcript CG3658-RA

(Aliases: anon-1Ec,Cdc45,dCDC45,D,CG3658,EG:BACR7A4.11,CDC45,DmCdc45,Dmel\CG3658)

FLYBASE: FBgn0026143
Entrez: 31052
UniProtKB: O96989

Process Predictions
Disease Predictions

CDC45L biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dna metabolic process	GO:0006259	227	0.992
dna replication	GO:0006260	48	0.968
cell cycle dna replication	GO:0044786	23	0.955	Yeast
cellular response to dna damage stimulus	GO:0006974	223	0.944
dna conformation change	GO:0071103	105	0.858
dna damage checkpoint	GO:0000077	78	0.837
g2 dna damage checkpoint	GO:0031572	69	0.831
mitotic dna damage checkpoint	GO:0044773	74	0.804
nuclear dna replication	GO:0033260	1	0.798	Yeast
positive regulation of macromolecule metabolic process	GO:0010604	405	0.752
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.726
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.710
mitotic g2 m transition checkpoint	GO:0044818	70	0.702
meiotic cell cycle process	GO:1903046	132	0.701
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.687
protein dna complex subunit organization	GO:0071824	86	0.675	Yeast
chromosome organization	GO:0051276	360	0.643
nuclear division	GO:0000280	332	0.569
dna dependent dna replication	GO:0006261	17	0.568	Yeast
meiotic chromosome segregation	GO:0045132	59	0.550
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.539	Yeast
recombinational repair	GO:0000725	13	0.517	Yeast
protein dna complex assembly	GO:0065004	63	0.516	Yeast
double strand break repair via homologous recombination	GO:0000724	13	0.474	Yeast
positive regulation of rna metabolic process	GO:0051254	271	0.452
organelle fission	GO:0048285	340	0.427
negative regulation of cell cycle phase transition	GO:1901988	103	0.398
double strand break repair	GO:0006302	26	0.392	Yeast
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.372
dna recombination	GO:0006310	32	0.369	Yeast
dna integrity checkpoint	GO:0031570	81	0.369
cell cycle checkpoint	GO:0000075	95	0.359
death	GO:0016265	284	0.357
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.353	Yeast
dna biosynthetic process	GO:0071897	24	0.349
single organism biosynthetic process	GO:0044711	206	0.337	Yeast
dna duplex unwinding	GO:0032508	16	0.315
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.301	Yeast
regulation of cell cycle	GO:0051726	291	0.295
negative regulation of transcription dna templated	GO:0045892	237	0.294	Yeast
gliogenesis	GO:0042063	80	0.292
mitotic cell cycle checkpoint	GO:0007093	88	0.274
mitotic g2 dna damage checkpoint	GO:0007095	69	0.268
reciprocal meiotic recombination	GO:0007131	19	0.266
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.263	Yeast
dna geometric change	GO:0032392	16	0.256
dna repair	GO:0006281	54	0.250	Yeast
dna endoreduplication	GO:0042023	22	0.249
chromatin organization	GO:0006325	207	0.245
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.231
cell division	GO:0051301	248	0.226
regulation of mitotic cell cycle	GO:0007346	190	0.217
regulation of cell cycle process	GO:0010564	181	0.215
positive regulation of rna biosynthetic process	GO:1902680	266	0.208
positive regulation of biosynthetic process	GO:0009891	316	0.202
negative regulation of gene expression epigenetic	GO:0045814	77	0.196	Yeast
negative regulation of cell cycle process	GO:0010948	109	0.194
cell death	GO:0008219	279	0.194
regulation of apoptotic process	GO:0042981	130	0.194
eye development	GO:0001654	323	0.190
regulation of programmed cell death	GO:0043067	152	0.189
dna packaging	GO:0006323	91	0.189
programmed cell death	GO:0012501	257	0.184
regulation of cell cycle phase transition	GO:1901987	130	0.181
negative regulation of cellular metabolic process	GO:0031324	382	0.181	Yeast
spermatogenesis	GO:0007283	200	0.177
regulation of localization	GO:0032879	275	0.173
macromolecular complex assembly	GO:0065003	256	0.170	Yeast
small molecule metabolic process	GO:0044281	305	0.165
eye morphogenesis	GO:0048592	260	0.158
purine ribonucleoside metabolic process	GO:0046128	127	0.157
male gamete generation	GO:0048232	201	0.149
organic substance transport	GO:0071702	257	0.147
aromatic compound catabolic process	GO:0019439	166	0.143
mitotic dna integrity checkpoint	GO:0044774	75	0.143
regulation of dna metabolic process	GO:0051052	34	0.138
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.137
regulation of hydrolase activity	GO:0051336	97	0.137
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.124
regulation of neurogenesis	GO:0050767	158	0.123
negative regulation of mitotic cell cycle	GO:0045930	109	0.122
positive regulation of cellular biosynthetic process	GO:0031328	316	0.121
apoptotic process	GO:0006915	159	0.118
vesicle mediated transport	GO:0016192	381	0.117
chromatin remodeling	GO:0006338	72	0.115
cell proliferation	GO:0008283	299	0.115
ribonucleoside metabolic process	GO:0009119	127	0.114
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.113
single organism intracellular transport	GO:1902582	207	0.110
purine nucleoside metabolic process	GO:0042278	127	0.105
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.104
establishment of localization in cell	GO:0051649	402	0.101
negative regulation of cellular biosynthetic process	GO:0031327	277	0.100	Yeast
positive regulation of gene expression	GO:0010628	290	0.098
double strand break repair via nonhomologous end joining	GO:0006303	5	0.098
regulation of nervous system development	GO:0051960	248	0.092
sensory organ morphogenesis	GO:0090596	260	0.089
regulation of cell death	GO:0010941	173	0.088
chromatin modification	GO:0016568	147	0.087
cellular protein modification process	GO:0006464	438	0.084
cellular catabolic process	GO:0044248	372	0.083
regulation of mitosis	GO:0007088	56	0.083
cytoplasmic transport	GO:0016482	130	0.081
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.079
negative regulation of rna biosynthetic process	GO:1902679	240	0.078	Yeast
embryo development ending in birth or egg hatching	GO:0009792	152	0.075	Worm
positive regulation of multicellular organismal process	GO:0051240	143	0.074
response to abiotic stimulus	GO:0009628	341	0.072
dna replication initiation	GO:0006270	6	0.072	Yeast
negative regulation of cell cycle	GO:0045786	116	0.072
negative regulation of biosynthetic process	GO:0009890	277	0.071	Yeast
mitotic cell cycle phase transition	GO:0044772	138	0.071
meiosis i	GO:0007127	59	0.070
mitotic nuclear division	GO:0007067	213	0.069
heterocycle catabolic process	GO:0046700	166	0.068
cellular macromolecule localization	GO:0070727	220	0.068
gonad development	GO:0008406	50	0.067
body morphogenesis	GO:0010171	2	0.067
histone modification	GO:0016570	106	0.066
organic substance catabolic process	GO:1901575	308	0.066
positive regulation of transcription dna templated	GO:0045893	266	0.064
protein transport	GO:0015031	155	0.064
organelle assembly	GO:0070925	198	0.063
positive regulation of developmental process	GO:0051094	143	0.063
regulation of gene expression epigenetic	GO:0040029	128	0.062	Yeast
nucleotide metabolic process	GO:0009117	161	0.061
meiotic nuclear division	GO:0007126	151	0.058
response to biotic stimulus	GO:0009607	294	0.056
response to external biotic stimulus	GO:0043207	293	0.056
protein modification process	GO:0036211	438	0.055
negative regulation of apoptotic process	GO:0043066	63	0.053
regulation of cell division	GO:0051302	72	0.053
cellular macromolecular complex assembly	GO:0034622	153	0.052	Yeast
negative regulation of rna metabolic process	GO:0051253	251	0.050	Yeast
regulation of multicellular organismal development	GO:2000026	414	0.050
compound eye morphogenesis	GO:0001745	249	0.049
purine containing compound metabolic process	GO:0072521	155	0.049
catabolic process	GO:0009056	409	0.048
endocytosis	GO:0006897	310	0.048
regulation of cellular localization	GO:0060341	136	0.048
regulation of cytoplasmic transport	GO:1903649	47	0.047
compound eye development	GO:0048749	307	0.047
chromosome segregation	GO:0007059	157	0.046
chromosome separation	GO:0051304	42	0.046
negative regulation of gene expression	GO:0010629	387	0.045	Yeast
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.044
regulation of protein metabolic process	GO:0051246	256	0.044
nucleobase containing compound catabolic process	GO:0034655	165	0.042
dna amplification	GO:0006277	11	0.041
regulation of transport	GO:0051049	181	0.041
regulation of developmental growth	GO:0048638	174	0.040
covalent chromatin modification	GO:0016569	106	0.039
ribose phosphate metabolic process	GO:0019693	145	0.039
glycosyl compound metabolic process	GO:1901657	127	0.039
purine nucleotide metabolic process	GO:0006163	146	0.038
ribonucleotide metabolic process	GO:0009259	145	0.038
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.037
eggshell chorion gene amplification	GO:0007307	9	0.037
organonitrogen compound metabolic process	GO:1901564	318	0.037
nucleoside phosphate metabolic process	GO:0006753	162	0.037
aging	GO:0007568	143	0.037
response to light stimulus	GO:0009416	124	0.036
female meiosis chromosome segregation	GO:0016321	33	0.036
reproductive structure development	GO:0048608	74	0.036
protein complex assembly	GO:0006461	200	0.035
regulation of catalytic activity	GO:0050790	185	0.035
purine nucleoside catabolic process	GO:0006152	112	0.034
negative regulation of programmed cell death	GO:0043069	72	0.034
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.032
regulation of molecular function	GO:0065009	217	0.032
larval development	GO:0002164	104	0.032
cell cycle phase transition	GO:0044770	140	0.032
cell fate determination	GO:0001709	91	0.031
glycosyl compound catabolic process	GO:1901658	112	0.031
purine nucleotide catabolic process	GO:0006195	109	0.030
nucleoside triphosphate metabolic process	GO:0009141	120	0.029
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.029
positive regulation of programmed cell death	GO:0043068	62	0.029
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.028
camera type eye morphogenesis	GO:0048593	2	0.028
carbohydrate derivative catabolic process	GO:1901136	118	0.028
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.027
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.027	Yeast
cell motility	GO:0048870	251	0.027
regulation of growth	GO:0040008	233	0.027
atp dependent chromatin remodeling	GO:0043044	22	0.027
multicellular organism growth	GO:0035264	46	0.026
nucleoside catabolic process	GO:0009164	112	0.026
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.026
positive regulation of gliogenesis	GO:0014015	5	0.026
regulation of nucleotide catabolic process	GO:0030811	48	0.026
translesion synthesis	GO:0019985	2	0.026
organophosphate metabolic process	GO:0019637	195	0.026
purine ribonucleoside catabolic process	GO:0046130	112	0.025
protein localization	GO:0008104	284	0.025
actin filament based process	GO:0030029	220	0.025
regulation of phosphate metabolic process	GO:0019220	210	0.024
positive regulation of nucleoside metabolic process	GO:0045979	47	0.024
establishment of protein localization	GO:0045184	163	0.024
camera type eye development	GO:0043010	4	0.023
carbohydrate derivative metabolic process	GO:1901135	217	0.022
small gtpase mediated signal transduction	GO:0007264	88	0.022
neuroblast proliferation	GO:0007405	74	0.022
regulation of phosphorus metabolic process	GO:0051174	210	0.022
response to other organism	GO:0051707	293	0.022
nuclear transport	GO:0051169	72	0.021
postreplication repair	GO:0006301	2	0.021
homeostatic process	GO:0042592	199	0.020
nucleotide catabolic process	GO:0009166	109	0.020
regulation of cellular catabolic process	GO:0031329	157	0.020
negative regulation of cell death	GO:0060548	81	0.020
amine metabolic process	GO:0009308	12	0.019
nucleotide excision repair	GO:0006289	8	0.019
regulation of response to stress	GO:0080134	200	0.019
central nervous system development	GO:0007417	201	0.019
regulation of chromatin silencing	GO:0031935	36	0.019	Yeast
ribonucleotide catabolic process	GO:0009261	109	0.019
organic cyclic compound catabolic process	GO:1901361	168	0.019
imaginal disc derived wing morphogenesis	GO:0007476	337	0.019
response to radiation	GO:0009314	155	0.018
tube morphogenesis	GO:0035239	191	0.018
organonitrogen compound catabolic process	GO:1901565	128	0.018
sex differentiation	GO:0007548	81	0.018
rna localization	GO:0006403	115	0.018
dendrite development	GO:0016358	204	0.018
cellular protein complex assembly	GO:0043623	71	0.018
nitrogen compound transport	GO:0071705	85	0.018
neuron recognition	GO:0008038	101	0.018
nls bearing protein import into nucleus	GO:0006607	5	0.017
axon development	GO:0061564	297	0.017
cellular nitrogen compound catabolic process	GO:0044270	165	0.017
guanosine containing compound metabolic process	GO:1901068	74	0.017
anatomical structure homeostasis	GO:0060249	97	0.017
regulation of dna repair	GO:0006282	5	0.017
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.017
nucleosome mobilization	GO:0042766	9	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.017
meiotic cell cycle	GO:0051321	171	0.017
establishment of rna localization	GO:0051236	47	0.016
appendage development	GO:0048736	401	0.016
protein localization to nucleus	GO:0034504	55	0.016
positive regulation of neurogenesis	GO:0050769	41	0.016
organophosphate catabolic process	GO:0046434	112	0.016
gtp metabolic process	GO:0046039	72	0.016
transcription from rna polymerase ii promoter	GO:0006366	368	0.016
sterol biosynthetic process	GO:0016126	9	0.016
telomere organization	GO:0032200	21	0.016
single organism nuclear import	GO:1902593	51	0.016
guanosine containing compound catabolic process	GO:1901069	74	0.016
gtp catabolic process	GO:0006184	72	0.015
mitotic sister chromatid segregation	GO:0000070	87	0.015
morphogenesis of an epithelium	GO:0002009	276	0.015
nucleoside metabolic process	GO:0009116	127	0.015
protein localization to organelle	GO:0033365	82	0.015
endomembrane system organization	GO:0010256	119	0.015
imaginal disc derived appendage development	GO:0048737	399	0.015
reproductive system development	GO:0061458	74	0.015
intracellular transport	GO:0046907	228	0.015
locomotory behavior	GO:0007626	176	0.015
regulation of cell differentiation	GO:0045595	302	0.015
wing disc morphogenesis	GO:0007472	344	0.015
regulation of nucleoside metabolic process	GO:0009118	50	0.015
regulation of cellular ketone metabolic process	GO:0010565	3	0.014
regulation of catabolic process	GO:0009894	170	0.014
regulation of purine nucleotide metabolic process	GO:1900542	62	0.014
protein ubiquitination	GO:0016567	70	0.014
regulation of organelle organization	GO:0033043	196	0.014
regulation of nucleocytoplasmic transport	GO:0046822	35	0.014
regulation of protein deacetylation	GO:0090311	2	0.014
positive regulation of endopeptidase activity	GO:0010950	26	0.014
double strand break repair via synthesis dependent strand annealing	GO:0045003	6	0.014
epithelial cell differentiation	GO:0030855	322	0.014
lipid metabolic process	GO:0006629	121	0.014
zymogen activation	GO:0031638	20	0.014
nuclear pore organization	GO:0006999	1	0.014
regulation of dna replication	GO:0006275	13	0.014
development of primary sexual characteristics	GO:0045137	50	0.014
compound eye photoreceptor cell differentiation	GO:0001751	140	0.014
meiotic chromosome separation	GO:0051307	8	0.014
positive regulation of cell cycle	GO:0045787	43	0.013
protein import	GO:0017038	55	0.013
positive regulation of cellular amine metabolic process	GO:0033240	0	0.013
nucleocytoplasmic transport	GO:0006913	72	0.013
single organism cellular localization	GO:1902580	180	0.013
nucleobase containing compound transport	GO:0015931	56	0.013
regulation of nuclear division	GO:0051783	58	0.013
regulation of purine nucleotide catabolic process	GO:0033121	48	0.013
cellular protein localization	GO:0034613	160	0.013
regulation of endopeptidase activity	GO:0052548	36	0.013
positive regulation of cell proliferation	GO:0008284	47	0.012
regulation of cellular response to stress	GO:0080135	89	0.012
dendrite morphogenesis	GO:0048813	199	0.012
regulation of dna dependent dna replication	GO:0090329	6	0.012
positive regulation of hydrolase activity	GO:0051345	78	0.012
post embryonic appendage morphogenesis	GO:0035120	385	0.012
negative regulation of dna metabolic process	GO:0051053	12	0.012
response to uv	GO:0009411	24	0.012
response to bacterium	GO:0009617	198	0.012
nucleobase containing small molecule metabolic process	GO:0055086	174	0.012
positive regulation of cell development	GO:0010720	61	0.012
single organism catabolic process	GO:0044712	228	0.012
protein targeting	GO:0006605	64	0.012
purine ribonucleotide catabolic process	GO:0009154	109	0.012
phosphorylation	GO:0016310	294	0.012
ovarian follicle cell development	GO:0030707	248	0.012
intercellular bridge organization	GO:0043063	14	0.012
mitotic sister chromatid separation	GO:0051306	30	0.012
chromatin silencing	GO:0006342	76	0.012	Yeast
regulation of protein localization	GO:0032880	76	0.012
phagocytosis	GO:0006909	215	0.012
ribonucleoside catabolic process	GO:0042454	112	0.012
positive regulation of apoptotic process	GO:0043065	47	0.012
axonogenesis	GO:0007409	290	0.012
regulation of cellular amino acid metabolic process	GO:0006521	0	0.012
response to lipopolysaccharide	GO:0032496	4	0.012
regulation of nucleotide metabolic process	GO:0006140	62	0.011
nuclear import	GO:0051170	51	0.011
secretion by cell	GO:0032940	101	0.011
secretion	GO:0046903	109	0.011
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.011
response to organic substance	GO:0010033	284	0.011
single organism behavior	GO:0044708	391	0.011
positive regulation of transport	GO:0051050	92	0.011
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.011
nucleoside phosphate catabolic process	GO:1901292	110	0.010
rna transport	GO:0050658	46	0.010
nucleoside triphosphate catabolic process	GO:0009143	108	0.010
regulation of cell proliferation	GO:0042127	163	0.010
multicellular organismal aging	GO:0010259	140	0.010
positive regulation of phosphorus metabolic process	GO:0010562	139	0.010
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.010
nucleosome organization	GO:0034728	59	0.010

CDC45L disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.034
cancer	DOID:162	0.034
organ system cancer	DOID:0050686	0.034
disease of anatomical entity	DOID:7	0.031

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