IMP: Integrative Multi-species Prediction

Drosophila melanogaster

199 known processes

kis (Dmel_CG3696)

kismet

(Aliases: l(2)k16510,CG18326,CG3696,l(2)k14112,anon-WO0257455.5,136/31,5841,Su(Pc)21AB,l(2)07812,l(2)k13631,l(2)s4793,Dmel\CG3696,l(2)k11324,KIS-L,l(2)s4771,l(2)k08827,kiss,KIS,anon-WO0172774.164,l(2)s3527,BEST:GM02209,Kis,GM02209,EK2-4,CG3660,2532)

Entrez: 33185
FLYBASE: FBgn0086902
UniProtKB: M9NEL3
UniProtKB: B7Z002
UniProtKB: M9NCY5
UniProtKB: M9NDB7
UniProtKB: Q9VPL6
UniProtKB: Q9VPL9

Process Predictions
Disease Predictions

kis biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regionalization	GO:0003002	416	0.995
neuron projection guidance	GO:0097485	241	0.991
axonogenesis	GO:0007409	290	0.967
segmentation	GO:0035282	207	0.967
positive regulation of cellular biosynthetic process	GO:0031328	316	0.967	Human
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.966	Human
positive regulation of transcription dna templated	GO:0045893	266	0.964	Human
epithelium migration	GO:0090132	148	0.956
epithelial cell migration	GO:0010631	148	0.954
cellular protein modification process	GO:0006464	438	0.954
transcription from rna polymerase ii promoter	GO:0006366	368	0.953	Human
regulation of gene expression epigenetic	GO:0040029	128	0.941
axon development	GO:0061564	297	0.933
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.921	Human
programmed cell death	GO:0012501	257	0.920	Mouse
positive regulation of gene expression	GO:0010628	290	0.918	Human
positive regulation of biosynthetic process	GO:0009891	316	0.910	Human
localization of cell	GO:0051674	257	0.898
peptidyl amino acid modification	GO:0018193	105	0.868
stem cell differentiation	GO:0048863	117	0.863
cellular response to dna damage stimulus	GO:0006974	223	0.862
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.860
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.857	Human
positive regulation of macromolecule metabolic process	GO:0010604	405	0.844	Human
epithelial cell development	GO:0002064	274	0.811
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.803	Human
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.801	Human
tissue migration	GO:0090130	155	0.798
response to oxygen containing compound	GO:1901700	200	0.795
regulation of cell differentiation	GO:0045595	302	0.793	Mouse
r7 cell differentiation	GO:0045466	43	0.777
negative regulation of signaling	GO:0023057	219	0.775	Human Rat
negative regulation of gene expression	GO:0010629	387	0.768
positive regulation of rna biosynthetic process	GO:1902680	266	0.750	Human
negative regulation of transcription dna templated	GO:0045892	237	0.725
protein modification process	GO:0036211	438	0.711
columnar cuboidal epithelial cell development	GO:0002066	249	0.709
cell death	GO:0008219	279	0.688	Mouse
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.684
positive regulation of rna metabolic process	GO:0051254	271	0.680	Human
nuclear transport	GO:0051169	72	0.675
regulation of growth	GO:0040008	233	0.671
negative regulation of signal transduction	GO:0009968	206	0.666	Human Rat
carbohydrate metabolic process	GO:0005975	82	0.665
chemotaxis	GO:0006935	249	0.663
wing disc morphogenesis	GO:0007472	344	0.663
appendage morphogenesis	GO:0035107	397	0.639
ovarian follicle cell development	GO:0030707	248	0.617
negative regulation of response to stimulus	GO:0048585	258	0.611	Human Rat
immune system process	GO:0002376	347	0.597
regulation of intracellular signal transduction	GO:1902531	236	0.590
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.577
central nervous system development	GO:0007417	201	0.563	Human Mouse
determination of adult lifespan	GO:0008340	137	0.560
appendage development	GO:0048736	401	0.557
regulation of cell death	GO:0010941	173	0.553	Mouse
cognition	GO:0050890	141	0.552
negative regulation of cell communication	GO:0010648	223	0.545	Human Rat
ovarian follicle cell migration	GO:0007297	121	0.522
imaginal disc pattern formation	GO:0007447	91	0.514
regulation of mitotic cell cycle	GO:0007346	190	0.507
defense response	GO:0006952	300	0.501
single organism carbohydrate metabolic process	GO:0044723	72	0.498
cell migration	GO:0016477	238	0.492
ameboidal type cell migration	GO:0001667	151	0.489
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.489	Human
regulation of protein modification process	GO:0031399	112	0.484
chromosome organization	GO:0051276	360	0.475	Human
regulation of cellular component biogenesis	GO:0044087	201	0.470
eye development	GO:0001654	323	0.465	Human Mouse
head development	GO:0060322	135	0.456	Human Mouse
positive regulation of response to stimulus	GO:0048584	323	0.447
protein modification by small protein conjugation	GO:0032446	79	0.445
regulation of phosphorus metabolic process	GO:0051174	210	0.432
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.417
immune response	GO:0006955	246	0.413
chromatin modification	GO:0016568	147	0.412	Human
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.403
negative regulation of biosynthetic process	GO:0009890	277	0.401
regulation of immune system process	GO:0002682	176	0.400
macromolecule catabolic process	GO:0009057	161	0.397
regulation of phosphate metabolic process	GO:0019220	210	0.395
positive regulation of cellular component biogenesis	GO:0044089	80	0.395
imaginal disc derived wing morphogenesis	GO:0007476	337	0.381
protein ubiquitination	GO:0016567	70	0.373
regulation of immune response	GO:0050776	118	0.361
positive regulation of cellular protein metabolic process	GO:0032270	118	0.349
negative regulation of cellular biosynthetic process	GO:0031327	277	0.348
rna processing	GO:0006396	147	0.348
intracellular signal transduction	GO:0035556	300	0.341
regulation of cellular protein metabolic process	GO:0032268	243	0.334
cell proliferation	GO:0008283	299	0.332
circulatory system development	GO:0072359	82	0.323	Human Mouse
positive regulation of protein metabolic process	GO:0051247	128	0.314
methylation	GO:0032259	47	0.312
response to organic substance	GO:0010033	284	0.306
apoptotic process	GO:0006915	159	0.305	Mouse
axon guidance	GO:0007411	233	0.301
negative regulation of cellular metabolic process	GO:0031324	382	0.298
regulation of neurogenesis	GO:0050767	158	0.294	Mouse
negative regulation of programmed cell death	GO:0043069	72	0.287	Mouse
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.273
striated muscle tissue development	GO:0014706	27	0.267
positive regulation of cellular component organization	GO:0051130	156	0.263
forebrain development	GO:0030900	2	0.263	Mouse
cell motility	GO:0048870	251	0.262
signal transduction by phosphorylation	GO:0023014	107	0.259
response to biotic stimulus	GO:0009607	294	0.255
regulation of organelle organization	GO:0033043	196	0.247
regulation of cell development	GO:0060284	215	0.243	Mouse
positive regulation of immune system process	GO:0002684	68	0.242
negative regulation of nervous system development	GO:0051961	92	0.241
organic substance transport	GO:0071702	257	0.240	Human
negative regulation of rna metabolic process	GO:0051253	251	0.240
multicellular organismal reproductive behavior	GO:0033057	110	0.236
imaginal disc derived appendage development	GO:0048737	399	0.234
cellular amine metabolic process	GO:0044106	12	0.232
negative regulation of gene expression epigenetic	GO:0045814	77	0.220
dendrite development	GO:0016358	204	0.219
intracellular transport	GO:0046907	228	0.217
multicellular organismal aging	GO:0010259	140	0.217
dna methylation or demethylation	GO:0044728	4	0.216
cardiovascular system development	GO:0072358	82	0.212	Human Mouse
establishment of localization in cell	GO:0051649	402	0.212	Human
mapk cascade	GO:0000165	107	0.207
posttranscriptional gene silencing	GO:0016441	46	0.206
learning	GO:0007612	75	0.205
larval midgut histolysis	GO:0035069	22	0.202
peptidyl lysine modification	GO:0018205	57	0.192
locomotory behavior	GO:0007626	176	0.191	Mouse
eye photoreceptor cell differentiation	GO:0001754	145	0.189
protein localization	GO:0008104	284	0.188
dephosphorylation	GO:0016311	51	0.187
regulation of transferase activity	GO:0051338	58	0.184
embryo development ending in birth or egg hatching	GO:0009792	152	0.184	Human Mouse
regulation of cellular response to insulin stimulus	GO:1900076	17	0.182
negative regulation of cytoplasmic transport	GO:1903650	8	0.181
protein catabolic process	GO:0030163	101	0.181
muscle structure development	GO:0061061	224	0.181
circadian rhythm	GO:0007623	105	0.173
positive regulation of immune response	GO:0050778	63	0.171
positive regulation of nf kappab import into nucleus	GO:0042346	1	0.170
histone modification	GO:0016570	106	0.170
regulation of protein localization	GO:0032880	76	0.168
compound eye photoreceptor cell differentiation	GO:0001751	140	0.168
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.164
regulation of programmed cell death	GO:0043067	152	0.164	Mouse
regulation of nervous system development	GO:0051960	248	0.161	Mouse
establishment of protein localization	GO:0045184	163	0.161
aging	GO:0007568	143	0.160
cell adhesion	GO:0007155	136	0.159
muscle tissue development	GO:0060537	30	0.159
post embryonic appendage morphogenesis	GO:0035120	385	0.157
cellular amino acid metabolic process	GO:0006520	61	0.156
epithelial cell differentiation	GO:0030855	322	0.155
hematopoietic or lymphoid organ development	GO:0048534	57	0.155	Human
negative regulation of cell proliferation	GO:0008285	69	0.151
negative regulation of multicellular organismal process	GO:0051241	142	0.150
embryonic pattern specification	GO:0009880	174	0.149
learning or memory	GO:0007611	141	0.149
developmental growth involved in morphogenesis	GO:0060560	65	0.149
modification dependent protein catabolic process	GO:0019941	78	0.144
carbohydrate derivative metabolic process	GO:1901135	217	0.144	Human
cell division	GO:0051301	248	0.142
long term memory	GO:0007616	62	0.141
regulation of protein metabolic process	GO:0051246	256	0.139
olfactory learning	GO:0008355	56	0.138
response to nitrogen compound	GO:1901698	90	0.134
gene silencing	GO:0016458	138	0.134
oxoacid metabolic process	GO:0043436	103	0.133
regulation of cell proliferation	GO:0042127	163	0.128
positive regulation of cell communication	GO:0010647	250	0.127
small molecule metabolic process	GO:0044281	305	0.126	Human
death	GO:0016265	284	0.125	Mouse
protein acylation	GO:0043543	42	0.125
response to insulin	GO:0032868	29	0.125
peptidyl threonine phosphorylation	GO:0018107	2	0.124
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.123
cellular carbohydrate metabolic process	GO:0044262	22	0.120
regulation of localization	GO:0032879	275	0.118	Human
macromolecular complex assembly	GO:0065003	256	0.117
regulation of cellular catabolic process	GO:0031329	157	0.117
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.115
organic substance catabolic process	GO:1901575	308	0.115	Human
sensory organ morphogenesis	GO:0090596	260	0.113	Human Mouse
regulation of cell cycle process	GO:0010564	181	0.111
phosphorylation	GO:0016310	294	0.111
imaginal disc derived wing vein specification	GO:0007474	48	0.110
positive regulation of protein modification process	GO:0031401	58	0.110
regulation of multicellular organismal development	GO:2000026	414	0.107	Mouse
negative regulation of notch signaling pathway	GO:0045746	41	0.106
positive regulation of signal transduction	GO:0009967	223	0.105
hemopoiesis	GO:0030097	46	0.105	Human
small gtpase mediated signal transduction	GO:0007264	88	0.103
amine metabolic process	GO:0009308	12	0.100
wnt signaling pathway	GO:0016055	98	0.100	Human Rat
positive regulation of signaling	GO:0023056	243	0.098
cellular macromolecule catabolic process	GO:0044265	136	0.098
single organism behavior	GO:0044708	391	0.097
protein complex localization	GO:0031503	4	0.095
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.095
regulation of cell growth	GO:0001558	43	0.094
covalent chromatin modification	GO:0016569	106	0.094
regulation of establishment of protein localization	GO:0070201	61	0.094
single organism intracellular transport	GO:1902582	207	0.094
chromatin silencing	GO:0006342	76	0.093
negative regulation of molecular function	GO:0044092	51	0.091
neuron projection extension	GO:1990138	32	0.091
regulation of cellular amino acid metabolic process	GO:0006521	0	0.088
segment specification	GO:0007379	33	0.087
protein modification by small protein conjugation or removal	GO:0070647	106	0.086
response to wounding	GO:0009611	94	0.086
catabolic process	GO:0009056	409	0.086	Human
dorsal ventral pattern formation	GO:0009953	133	0.083
response to external biotic stimulus	GO:0043207	293	0.083
nucleocytoplasmic transport	GO:0006913	72	0.082
positive regulation of response to external stimulus	GO:0032103	44	0.080
tube development	GO:0035295	244	0.080	Mouse
negative regulation of cellular component organization	GO:0051129	108	0.079
regulation of mapk cascade	GO:0043408	92	0.079
negative regulation of intracellular signal transduction	GO:1902532	57	0.079
open tracheal system development	GO:0007424	204	0.079
wing disc pattern formation	GO:0035222	66	0.078
positive regulation of cellular catabolic process	GO:0031331	95	0.077
response to endogenous stimulus	GO:0009719	119	0.076
camera type eye development	GO:0043010	4	0.074	Human Mouse
posttranscriptional regulation of gene expression	GO:0010608	145	0.074
positive regulation of molecular function	GO:0044093	136	0.074
regulation of cellular component size	GO:0032535	98	0.073
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.073
negative regulation of cell differentiation	GO:0045596	143	0.072
regulation of neuron projection development	GO:0010975	69	0.072
regulation of response to stress	GO:0080134	200	0.072
skeletal muscle tissue development	GO:0007519	13	0.072
cell activation	GO:0001775	9	0.071	Human
extrinsic apoptotic signaling pathway	GO:0097191	1	0.071
insulin receptor signaling pathway	GO:0008286	25	0.069
regulation of protein import into nucleus	GO:0042306	28	0.069
regulation of protein transport	GO:0051223	57	0.068
response to other organism	GO:0051707	293	0.068
regulation of cellular amine metabolic process	GO:0033238	3	0.068
chromatin organization	GO:0006325	207	0.067	Human
nucleobase containing compound catabolic process	GO:0034655	165	0.067	Human
negative regulation of developmental process	GO:0051093	201	0.065
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.065
regulation of stem cell proliferation	GO:0072091	40	0.064
notch signaling pathway	GO:0007219	120	0.062
endocytosis	GO:0006897	310	0.060
myotube differentiation	GO:0014902	46	0.059
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.059
cellular protein catabolic process	GO:0044257	83	0.058
intracellular protein transport	GO:0006886	104	0.058
negative regulation of tor signaling	GO:0032007	5	0.058
imaginal disc derived leg segmentation	GO:0036011	26	0.058
brain development	GO:0007420	120	0.056	Mouse
adult behavior	GO:0030534	137	0.056	Mouse
innate immune response	GO:0045087	144	0.056
cellular response to chemical stimulus	GO:0070887	199	0.056	Human
regulation of developmental growth	GO:0048638	174	0.055
regulation of cytoplasmic transport	GO:1903649	47	0.055
positive regulation of cellular amine metabolic process	GO:0033240	0	0.055
regulation of cellular ketone metabolic process	GO:0010565	3	0.055
response to organic cyclic compound	GO:0014070	89	0.055
regulation of molecular function	GO:0065009	217	0.055
cytoplasmic sequestering of protein	GO:0051220	4	0.054
single organism nuclear import	GO:1902593	51	0.053
morphogenesis of follicular epithelium	GO:0016333	36	0.053
establishment of mitotic spindle localization	GO:0040001	17	0.053
cellular macromolecular complex assembly	GO:0034622	153	0.052
negative regulation of rna biosynthetic process	GO:1902679	240	0.052
regulation of intracellular protein transport	GO:0033157	46	0.052
immune system development	GO:0002520	57	0.052	Human
regulation of cell cycle	GO:0051726	291	0.051
negative regulation of insulin receptor signaling pathway	GO:0046627	11	0.051
dna methylation	GO:0006306	4	0.051
regulation of insulin receptor signaling pathway	GO:0046626	17	0.050
neurological system process	GO:0050877	358	0.049
ubiquitin dependent protein catabolic process	GO:0006511	78	0.049
single organism cellular localization	GO:1902580	180	0.049
protein import into nucleus	GO:0006606	51	0.049
protein transport	GO:0015031	155	0.048
nitrogen compound transport	GO:0071705	85	0.048	Human
developmental cell growth	GO:0048588	52	0.048
multi multicellular organism process	GO:0044706	123	0.048
regulation of phosphorylation	GO:0042325	147	0.047
blastoderm segmentation	GO:0007350	159	0.047
muscle organ development	GO:0007517	127	0.047
nuclear import	GO:0051170	51	0.047
cell growth	GO:0016049	108	0.046
r7 cell fate commitment	GO:0007465	12	0.046
cellular response to peptide	GO:1901653	28	0.046
negative regulation of protein metabolic process	GO:0051248	85	0.046
cell type specific apoptotic process	GO:0097285	38	0.046	Mouse
rhythmic behavior	GO:0007622	76	0.045
positive regulation of phosphorus metabolic process	GO:0010562	139	0.045
protein dephosphorylation	GO:0006470	27	0.045
regulation of response to wounding	GO:1903034	19	0.045
taxis	GO:0042330	304	0.044
dendrite morphogenesis	GO:0048813	199	0.044
negative regulation of neurogenesis	GO:0050768	53	0.044
mitotic chromosome condensation	GO:0007076	22	0.043
border follicle cell migration	GO:0007298	113	0.043
smoothened signaling pathway	GO:0007224	49	0.043
regulation of ras protein signal transduction	GO:0046578	93	0.042
eggshell formation	GO:0030703	105	0.042
mitotic nuclear division	GO:0007067	213	0.042
regulation of carbohydrate metabolic process	GO:0006109	10	0.042
synaptic vesicle localization	GO:0097479	53	0.041
histolysis	GO:0007559	102	0.041
neuron fate commitment	GO:0048663	50	0.041
cytoplasmic transport	GO:0016482	130	0.041
response to abiotic stimulus	GO:0009628	341	0.040
ras protein signal transduction	GO:0007265	88	0.040
regulation of apoptotic process	GO:0042981	130	0.040	Mouse
endomembrane system organization	GO:0010256	119	0.040
phosphatidylinositol 3 kinase signaling	GO:0014065	4	0.040
positive regulation of phosphate metabolic process	GO:0045937	139	0.039
chromosome condensation	GO:0030261	41	0.039
organelle localization	GO:0051640	148	0.039
wing disc dorsal ventral pattern formation	GO:0048190	47	0.039
positive regulation of developmental process	GO:0051094	143	0.038
glycoprotein metabolic process	GO:0009100	41	0.038
negative regulation of protein modification process	GO:0031400	29	0.037
regulation of intracellular transport	GO:0032386	64	0.037
skeletal muscle organ development	GO:0060538	48	0.037
regulation of catalytic activity	GO:0050790	185	0.036
vesicle mediated transport	GO:0016192	381	0.036
regulation of cell morphogenesis	GO:0022604	163	0.036
response to hormone	GO:0009725	45	0.036
eye morphogenesis	GO:0048592	260	0.036
cellular response to endogenous stimulus	GO:0071495	80	0.035
growth	GO:0040007	359	0.034
protein complex assembly	GO:0006461	200	0.034
scf dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031146	1	0.033
positive regulation of developmental growth	GO:0048639	62	0.033
mrna metabolic process	GO:0016071	124	0.033
organic acid metabolic process	GO:0006082	103	0.033
carbohydrate derivative biosynthetic process	GO:1901137	85	0.033
immune effector process	GO:0002252	98	0.033
mrna processing	GO:0006397	104	0.032
protein alkylation	GO:0008213	43	0.032
intracellular receptor signaling pathway	GO:0030522	19	0.032
leg disc development	GO:0035218	92	0.032
body morphogenesis	GO:0010171	2	0.031
photoreceptor cell fate commitment	GO:0046552	41	0.031
gland development	GO:0048732	191	0.031
chemosensory behavior	GO:0007635	106	0.031	Mouse
regulation of protein localization to nucleus	GO:1900180	29	0.031
regulation of anatomical structure morphogenesis	GO:0022603	242	0.030
oviposition	GO:0018991	19	0.030
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.030
histone acetylation	GO:0016573	38	0.030
regulation of notch signaling pathway	GO:0008593	100	0.029
histone ubiquitination	GO:0016574	4	0.029
regulation of proteasomal protein catabolic process	GO:0061136	39	0.029
compound eye development	GO:0048749	307	0.029
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.029
rna interference	GO:0016246	27	0.029
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.029
cellular response to insulin stimulus	GO:0032869	28	0.028
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.028
positive regulation of phosphorylation	GO:0042327	87	0.028
stress activated mapk cascade	GO:0051403	52	0.028
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.028
embryonic organ development	GO:0048568	50	0.028	Human Mouse
photoreceptor cell development	GO:0042461	96	0.027
response to organonitrogen compound	GO:0010243	75	0.027
regulation of catabolic process	GO:0009894	170	0.027
regulation of nucleocytoplasmic transport	GO:0046822	35	0.027
memory	GO:0007613	94	0.026
olfactory behavior	GO:0042048	97	0.026	Mouse
stem cell development	GO:0048864	79	0.026
cellular response to nitrogen compound	GO:1901699	51	0.026
ncrna metabolic process	GO:0034660	43	0.026
dna alkylation	GO:0006305	4	0.026
cellular response to organic substance	GO:0071310	132	0.025
regulation of protein ubiquitination	GO:0031396	22	0.025
regulation of cell projection organization	GO:0031344	92	0.025
multicellular organismal homeostasis	GO:0048871	41	0.025
imaginal disc derived leg morphogenesis	GO:0007480	80	0.024
induction of programmed cell death by ecdysone	GO:0035078	12	0.024
positive regulation of organelle organization	GO:0010638	65	0.024
regulation of cytoskeleton organization	GO:0051493	89	0.024
membrane organization	GO:0061024	112	0.024
gtp catabolic process	GO:0006184	72	0.024
positive regulation of catabolic process	GO:0009896	105	0.024
glycoprotein biosynthetic process	GO:0009101	41	0.024
imaginal disc derived leg joint morphogenesis	GO:0016348	15	0.024
organonitrogen compound metabolic process	GO:1901564	318	0.024	Human
positive regulation of growth	GO:0045927	75	0.023
cellular catabolic process	GO:0044248	372	0.023	Human
response to bacterium	GO:0009617	198	0.022
regulation of dna templated transcription elongation	GO:0032784	17	0.022
homeostatic process	GO:0042592	199	0.022
proteolysis	GO:0006508	192	0.022
regulation of cellular protein catabolic process	GO:1903362	44	0.022
protein targeting to nucleus	GO:0044744	51	0.022
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.021
erbb signaling pathway	GO:0038127	58	0.021
cellular response to external stimulus	GO:0071496	66	0.021
negative regulation of phosphate metabolic process	GO:0045936	45	0.021
negative regulation of phosphorus metabolic process	GO:0010563	45	0.021
positive regulation of defense response to bacterium	GO:1900426	23	0.021
nuclear division	GO:0000280	332	0.021
regulation of transcription elongation from rna polymerase ii promoter	GO:0034243	15	0.021
negative regulation of phosphorylation	GO:0042326	35	0.021
positive regulation of cell development	GO:0010720	61	0.020
mesenchymal cell development	GO:0014031	1	0.020
regulation of synapse assembly	GO:0051963	94	0.020
response to dsrna	GO:0043331	15	0.020
regulation of protein phosphorylation	GO:0001932	64	0.020
negative regulation of cellular protein metabolic process	GO:0032269	85	0.020
synaptic growth at neuromuscular junction	GO:0051124	119	0.020
regulation of extent of cell growth	GO:0061387	8	0.020
meiotic cell cycle process	GO:1903046	132	0.020
establishment of protein localization to organelle	GO:0072594	62	0.019
negative regulation of epithelial cell proliferation	GO:0050680	4	0.019
lipid metabolic process	GO:0006629	121	0.019
regulation of wnt signaling pathway	GO:0030111	68	0.019	Human Rat
protein heterooligomerization	GO:0051291	4	0.019
carboxylic acid metabolic process	GO:0019752	92	0.019
somatic muscle development	GO:0007525	66	0.019
peptidyl lysine trimethylation	GO:0018023	6	0.019
receptor clustering	GO:0043113	3	0.019
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.019
negative regulation of developmental growth	GO:0048640	64	0.019
regulation of cellular response to stress	GO:0080135	89	0.019
mitotic sister chromatid segregation	GO:0000070	87	0.019
rna catabolic process	GO:0006401	37	0.019
peripheral nervous system development	GO:0007422	52	0.019
regulation of microtubule based process	GO:0032886	49	0.019
positive regulation of transport	GO:0051050	92	0.018
positive regulation of hh target transcription factor activity	GO:0007228	5	0.018
gene silencing by rna	GO:0031047	57	0.018
periodic partitioning	GO:0007365	29	0.018
positive regulation of transferase activity	GO:0051347	26	0.018
regulation of protein export from nucleus	GO:0046825	3	0.018
positive regulation of apoptotic process	GO:0043065	47	0.018
regulation of rna splicing	GO:0043484	69	0.018
segment polarity determination	GO:0007367	25	0.018
macromolecular complex disassembly	GO:0032984	37	0.018
positive regulation of response to extracellular stimulus	GO:0032106	8	0.018
chemical homeostasis	GO:0048878	92	0.018
circadian behavior	GO:0048512	76	0.018
regulation of multi organism process	GO:0043900	131	0.017
cellular response to oxygen containing compound	GO:1901701	79	0.017
single organism membrane organization	GO:0044802	93	0.017
protein phosphorylation	GO:0006468	169	0.017
positive regulation of programmed cell death	GO:0043068	62	0.017
posttranscriptional gene silencing by rna	GO:0035194	45	0.016
cellular response to hormone stimulus	GO:0032870	44	0.016
multicellular organism growth	GO:0035264	46	0.016	Mouse
regulation of cell substrate adhesion	GO:0010810	2	0.016
positive regulation of intracellular signal transduction	GO:1902533	116	0.016
regulation of glial cell proliferation	GO:0060251	11	0.016
cell fate determination	GO:0001709	91	0.016
regulation of response to external stimulus	GO:0032101	115	0.016
regulation of lamellipodium organization	GO:1902743	15	0.016
cellular nitrogen compound catabolic process	GO:0044270	165	0.016	Human
apoptotic signaling pathway	GO:0097190	27	0.016
response to lipid	GO:0033993	38	0.016
negative regulation of glial cell proliferation	GO:0060253	6	0.016
epithelial tube morphogenesis	GO:0060562	88	0.015
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.015
positive regulation of cellular protein catabolic process	GO:1903364	24	0.015
establishment of epithelial cell planar polarity	GO:0090163	4	0.015
anterior posterior pattern specification	GO:0009952	136	0.015
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.015
regulation of autophagy	GO:0010506	62	0.015
camera type eye morphogenesis	GO:0048593	2	0.015
positive regulation of multicellular organismal process	GO:0051240	143	0.015
regulation of lipid transport	GO:0032368	3	0.015
negative regulation of mapk cascade	GO:0043409	23	0.015
response to ecdysone	GO:0035075	34	0.015
cytoskeleton dependent intracellular transport	GO:0030705	44	0.015
translation	GO:0006412	69	0.015
peptidyl lysine methylation	GO:0018022	16	0.014
multi organism behavior	GO:0051705	175	0.014
compound eye photoreceptor fate commitment	GO:0001752	36	0.014
peptidyl lysine acetylation	GO:0018394	39	0.014
defense response to other organism	GO:0098542	225	0.014
regulation of cell cycle phase transition	GO:1901987	130	0.014
regulation of stress activated mapk cascade	GO:0032872	41	0.014
regulation of chromosome organization	GO:0033044	64	0.014
stress activated protein kinase signaling cascade	GO:0031098	55	0.014
apposition of dorsal and ventral imaginal disc derived wing surfaces	GO:0007475	15	0.014
response to transforming growth factor beta	GO:0071559	18	0.014
regulation of neuron differentiation	GO:0045664	103	0.014
cellular homeostasis	GO:0019725	80	0.014
cytokinesis	GO:0000910	90	0.014

kis disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of cellular proliferation	DOID:14566	0.061
disease of anatomical entity	DOID:7	0.037	Human
organ system cancer	DOID:0050686	0.032
cancer	DOID:162	0.032
nervous system disease	DOID:863	0.031

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