IMP: Integrative Multi-species Prediction

Drosophila melanogaster

444 known processes

N (Dmel_CG3936)

Notch

(Aliases: co,1.1,16-178,EG:163A10.2,Chp,spl,l(1)Ax,dNotch,16-55,swb,nd,anon-EST:Liang-1.12,CT13012,n[fah],Dmel\CG3936,fa,CG3936,Co,clone 1.12,l(1)N,EG:140G11.1,shd,l(1)3Cb,Ax,notch)

FLYBASE: FBgn0004647
Entrez: 31293
UniProtKB: M9NE67
UniProtKB: P07207

Process Predictions
Disease Predictions

N biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
morphogenesis of an epithelium	GO:0002009	276	1.000
tissue morphogenesis	GO:0048729	297	1.000
r7 cell differentiation	GO:0045466	43	1.000
imaginal disc derived appendage morphogenesis	GO:0035114	395	1.000
r3 r4 cell differentiation	GO:0048056	12	1.000
ovarian follicle cell development	GO:0030707	248	1.000
learning or memory	GO:0007611	141	1.000
photoreceptor cell differentiation	GO:0046530	170	1.000
columnar cuboidal epithelial cell differentiation	GO:0002065	256	1.000
cell fate determination	GO:0001709	91	1.000
regulation of notch signaling pathway	GO:0008593	100	1.000
immune system process	GO:0002376	347	1.000
negative regulation of multicellular organismal process	GO:0051241	142	0.999
cell projection assembly	GO:0030031	94	0.999
digestive tract development	GO:0048565	149	0.999
negative regulation of cellular metabolic process	GO:0031324	382	0.999	Mouse
establishment of planar polarity	GO:0001736	87	0.998
cardiocyte differentiation	GO:0035051	29	0.998
compound eye morphogenesis	GO:0001745	249	0.998
crystal cell differentiation	GO:0042688	7	0.998
r3 r4 cell fate commitment	GO:0007464	10	0.998
eggshell formation	GO:0030703	105	0.997
negative regulation of developmental process	GO:0051093	201	0.997
cell fate specification	GO:0001708	71	0.997
chorion containing eggshell formation	GO:0007304	105	0.997
morphogenesis of a polarized epithelium	GO:0001738	93	0.997
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.997	Mouse
establishment of ommatidial planar polarity	GO:0042067	49	0.997
stem cell development	GO:0048864	79	0.996
post embryonic appendage morphogenesis	GO:0035120	385	0.996
cellular protein modification process	GO:0006464	438	0.994
regulation of cellular component biogenesis	GO:0044087	201	0.994
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.994
transcription from rna polymerase ii promoter	GO:0006366	368	0.994
respiratory system development	GO:0060541	213	0.994
germarium derived egg chamber formation	GO:0007293	101	0.994
central nervous system development	GO:0007417	201	0.994	Zebrafish Mouse Rat
positive regulation of neural precursor cell proliferation	GO:2000179	8	0.993	Rat
embryonic organ development	GO:0048568	50	0.993
epithelial cell type specification open tracheal system	GO:0035153	11	0.993
forebrain development	GO:0030900	2	0.992	Zebrafish Mouse
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.992	Mouse
eye morphogenesis	GO:0048592	260	0.991
synaptic transmission	GO:0007268	288	0.990
eggshell chorion assembly	GO:0007306	66	0.989
establishment or maintenance of cell polarity	GO:0007163	167	0.988
hemocyte differentiation	GO:0042386	38	0.988
eye photoreceptor cell differentiation	GO:0001754	145	0.987
multi organism behavior	GO:0051705	175	0.986	Worm
regulation of cell proliferation	GO:0042127	163	0.985
regulation of anatomical structure morphogenesis	GO:0022603	242	0.985
epithelial cell development	GO:0002064	274	0.984
dorsal appendage formation	GO:0046843	47	0.984
digestive tract morphogenesis	GO:0048546	127	0.983
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.983
nuclear division	GO:0000280	332	0.982	Worm
gland development	GO:0048732	191	0.982
negative regulation of biosynthetic process	GO:0009890	277	0.982	Mouse
cardiovascular system development	GO:0072358	82	0.981
tube development	GO:0035295	244	0.980
stem cell differentiation	GO:0048863	117	0.979
regulation of nervous system development	GO:0051960	248	0.979
sensory organ morphogenesis	GO:0090596	260	0.979
stem cell maintenance	GO:0019827	67	0.978
columnar cuboidal epithelial cell development	GO:0002066	249	0.978
organelle fission	GO:0048285	340	0.977	Worm
embryonic morphogenesis	GO:0048598	206	0.976
cell proliferation	GO:0008283	299	0.976
regulation of stem cell proliferation	GO:0072091	40	0.975	Rat
open tracheal system development	GO:0007424	204	0.975
genital disc development	GO:0035215	44	0.974
neurological system process	GO:0050877	358	0.971
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	26	0.970
negative regulation of gene expression	GO:0010629	387	0.969
positive regulation of nervous system development	GO:0051962	69	0.969	Mouse Rat
cell surface receptor signaling pathway involved in heart development	GO:0061311	3	0.968	Human Mouse
circulatory system development	GO:0072359	82	0.968
ovarian follicle cell stalk formation	GO:0030713	17	0.967
renal system development	GO:0072001	72	0.967
renal tubule development	GO:0061326	64	0.966
negative regulation of cell differentiation	GO:0045596	143	0.964
response to organonitrogen compound	GO:0010243	75	0.963	Mouse
pericardium morphogenesis	GO:0003344	2	0.962	Mouse
neuron projection guidance	GO:0097485	241	0.961
imaginal disc derived appendage development	GO:0048737	399	0.959
cognition	GO:0050890	141	0.957
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.956	Mouse
chemotaxis	GO:0006935	249	0.953
heart field specification	GO:0003128	0	0.951
axon guidance	GO:0007411	233	0.950
neuronal stem cell maintenance	GO:0097150	4	0.948	Human Zebrafish
heart induction	GO:0003129	3	0.947
protein complex assembly	GO:0006461	200	0.945
establishment of tissue polarity	GO:0007164	87	0.943
regulation of cell morphogenesis	GO:0022604	163	0.942	Human Mouse
notch signaling pathway	GO:0007219	120	0.939
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.938
appendage morphogenesis	GO:0035107	397	0.936
synapse assembly	GO:0007416	143	0.936
single organism behavior	GO:0044708	391	0.935
cell fate commitment involved in pattern specification	GO:0060581	31	0.935
synapse organization	GO:0050808	196	0.935
epithelial tube morphogenesis	GO:0060562	88	0.934
regulation of molecular function	GO:0065009	217	0.930	Mouse
compound eye photoreceptor cell differentiation	GO:0001751	140	0.929
wing disc morphogenesis	GO:0007472	344	0.928
epithelial cell differentiation	GO:0030855	322	0.927
negative regulation of rna biosynthetic process	GO:1902679	240	0.926	Mouse
wnt signaling pathway involved in heart development	GO:0003306	3	0.923
regulation of glial cell differentiation	GO:0045685	1	0.922	Mouse Rat
axon development	GO:0061564	297	0.919
compound eye development	GO:0048749	307	0.916
telencephalon development	GO:0021537	2	0.912
negative regulation of neurogenesis	GO:0050768	53	0.910
dendrite morphogenesis	GO:0048813	199	0.907
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.907
regulation of multicellular organismal development	GO:2000026	414	0.907
mesoderm development	GO:0007498	78	0.906
regionalization	GO:0003002	416	0.905
digestive system development	GO:0055123	149	0.899
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.888	Mouse
brain development	GO:0007420	120	0.887	Zebrafish Mouse Rat
regulation of neural precursor cell proliferation	GO:2000177	35	0.886	Rat
kidney epithelium development	GO:0072073	3	0.885	Mouse
organelle localization	GO:0051640	148	0.883
response to nitrogen compound	GO:1901698	90	0.882	Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.881	Human Mouse
hemopoiesis	GO:0030097	46	0.879
muscle cell differentiation	GO:0042692	103	0.875
epithelium migration	GO:0090132	148	0.874
regulation of cell cycle	GO:0051726	291	0.874
regulation of dendrite morphogenesis	GO:0048814	28	0.869
regulation of catabolic process	GO:0009894	170	0.869
regulation of mitosis	GO:0007088	56	0.863
defense response	GO:0006952	300	0.862	Mouse
canonical wnt signaling pathway involved in heart development	GO:0061316	3	0.862
memory	GO:0007613	94	0.861
regulation of heart morphogenesis	GO:2000826	3	0.859	Mouse Rat
germ cell migration	GO:0008354	43	0.859
regulation of neurogenesis	GO:0050767	158	0.854
renal tubule morphogenesis	GO:0061333	44	0.850
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.850	Mouse
dendrite regeneration	GO:0031104	2	0.849
retinal ganglion cell axon guidance	GO:0031290	12	0.847
phosphorylation	GO:0016310	294	0.841
regulation of cardioblast cell fate specification	GO:0042686	8	0.838
dorsal ventral pattern formation	GO:0009953	133	0.838
dna metabolic process	GO:0006259	227	0.837
actin filament bundle organization	GO:0061572	28	0.825
regulation of growth	GO:0040008	233	0.825
gland morphogenesis	GO:0022612	145	0.824	Mouse
regulation of neuron projection development	GO:0010975	69	0.822
regulation of cytoskeleton organization	GO:0051493	89	0.821
motor neuron axon guidance	GO:0008045	58	0.820
regulation of photoreceptor cell differentiation	GO:0046532	34	0.815
immune system development	GO:0002520	57	0.815
positive regulation of biosynthetic process	GO:0009891	316	0.814
positive regulation of cell differentiation	GO:0045597	64	0.813	Human Zebrafish Mouse Rat
cardioblast cell fate specification	GO:0042685	9	0.810
morphogenesis of a branching structure	GO:0001763	45	0.809	Mouse
organic substance catabolic process	GO:1901575	308	0.804
photoreceptor cell fate commitment	GO:0046552	41	0.802
regulation of cell division	GO:0051302	72	0.801	Worm
cellular response to inorganic substance	GO:0071241	8	0.799
negative regulation of nervous system development	GO:0051961	92	0.789
multi multicellular organism process	GO:0044706	123	0.778	Worm
regulation of cell differentiation	GO:0045595	302	0.777
neuron fate commitment	GO:0048663	50	0.776	Mouse
spindle organization	GO:0007051	253	0.775
eye photoreceptor cell fate commitment	GO:0042706	37	0.775
photoreceptor cell development	GO:0042461	96	0.773
protein localization to organelle	GO:0033365	82	0.772
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.771
positive regulation of cellular biosynthetic process	GO:0031328	316	0.770
hair cell differentiation	GO:0035315	47	0.769	Mouse
malpighian tubule tip cell differentiation	GO:0061382	9	0.766
response to endogenous stimulus	GO:0009719	119	0.765	Human Mouse Rat
neuroblast differentiation	GO:0014016	29	0.764
morphogenesis of embryonic epithelium	GO:0016331	94	0.763
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	2	0.761
head development	GO:0060322	135	0.760	Zebrafish Mouse Rat
pericardium development	GO:0060039	2	0.749	Mouse
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded	GO:0008070	2	0.749
urogenital system development	GO:0001655	72	0.748
oocyte morphogenesis	GO:0048601	3	0.745
nephron development	GO:0072006	3	0.736	Mouse
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.732
developmental growth involved in morphogenesis	GO:0060560	65	0.732	Mouse
multicellular organismal reproductive behavior	GO:0033057	110	0.732	Worm
cell division	GO:0051301	248	0.728	Zebrafish Mouse Worm
positive regulation of developmental process	GO:0051094	143	0.725	Human Zebrafish Mouse Rat
cellular component assembly involved in morphogenesis	GO:0010927	151	0.722
positive regulation of cell proliferation	GO:0008284	47	0.721
establishment or maintenance of polarity of larval imaginal disc epithelium	GO:0016336	3	0.717
appendage development	GO:0048736	401	0.715
ribose phosphate metabolic process	GO:0019693	145	0.713
dorsal closure	GO:0007391	79	0.710
olfactory behavior	GO:0042048	97	0.704
response to organic substance	GO:0010033	284	0.704	Human Mouse Rat
fusion cell fate specification	GO:0035156	4	0.703
catabolic process	GO:0009056	409	0.700
regulation of striated muscle tissue development	GO:0016202	5	0.696	Human Mouse
positive regulation of ribosome biogenesis	GO:0090070	3	0.694
regulation of cellular catabolic process	GO:0031329	157	0.692
negative regulation of gene expression epigenetic	GO:0045814	77	0.690
cellular catabolic process	GO:0044248	372	0.689
regulation of cellular response to growth factor stimulus	GO:0090287	13	0.687
positive regulation of rna biosynthetic process	GO:1902680	266	0.685
purine ribonucleotide metabolic process	GO:0009150	145	0.685
dorsal closure leading edge cell differentiation	GO:0046663	2	0.684
protein modification process	GO:0036211	438	0.683
compound eye photoreceptor fate commitment	GO:0001752	36	0.679
regulation of cell cycle process	GO:0010564	181	0.678
positive regulation of transcription dna templated	GO:0045893	266	0.675
positive regulation of cell development	GO:0010720	61	0.673	Human Mouse Rat
regulation of organelle organization	GO:0033043	196	0.673	Worm
cuticle development	GO:0042335	86	0.670
mitotic spindle organization	GO:0007052	220	0.664
response to oxygen containing compound	GO:1901700	200	0.662	Mouse Rat
organ induction	GO:0001759	3	0.656
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.652
negative regulation of cell communication	GO:0010648	223	0.650	Mouse
intracellular signal transduction	GO:0035556	300	0.643
regulation of imaginal disc derived wing size	GO:0044719	20	0.642
meiotic nuclear envelope disassembly	GO:0051078	2	0.636
centrosome cycle	GO:0007098	137	0.634
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.633	Mouse
bmp signaling pathway	GO:0030509	27	0.625	Mouse
specification of organ identity	GO:0010092	3	0.622
epithelial cell migration	GO:0010631	148	0.622
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.619	Mouse
embryonic heart tube development	GO:0035050	22	0.618	Mouse
renal filtration cell differentiation	GO:0061318	12	0.612	Mouse
growth	GO:0040007	359	0.602
genitalia morphogenesis	GO:0035112	16	0.595
compound eye photoreceptor development	GO:0042051	78	0.591
attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation	GO:0051316	1	0.589
small molecule metabolic process	GO:0044281	305	0.583
branching morphogenesis of an epithelial tube	GO:0048754	45	0.583	Mouse
left right axis specification	GO:0070986	1	0.582	Mouse
cardiac muscle tissue development	GO:0048738	9	0.579	Mouse
positive regulation of programmed cell death	GO:0043068	62	0.578	Mouse
sex differentiation	GO:0007548	81	0.576
developmental growth	GO:0048589	280	0.575	Zebrafish Mouse Rat
cardioblast differentiation	GO:0010002	20	0.573
muscle structure development	GO:0061061	224	0.568
regulation of gene expression epigenetic	GO:0040029	128	0.563
oocyte fate commitment	GO:0048600	2	0.561
organonitrogen compound metabolic process	GO:1901564	318	0.561
salivary gland morphogenesis	GO:0007435	145	0.559
negative regulation of cardioblast differentiation	GO:0051892	7	0.559
epithelial cell proliferation	GO:0050673	15	0.555
positive regulation of gene expression	GO:0010628	290	0.554
cellular response to chemical stimulus	GO:0070887	199	0.553	Human Mouse
meiotic chromosome movement towards spindle pole	GO:0016344	1	0.553
response to transforming growth factor beta	GO:0071559	18	0.547
regulation of tube architecture open tracheal system	GO:0035152	68	0.545
localization of cell	GO:0051674	257	0.545
dna conformation change	GO:0071103	105	0.544
regulation of neuron differentiation	GO:0045664	103	0.540
second mitotic wave involved in compound eye morphogenesis	GO:0016330	7	0.539
neural precursor cell proliferation	GO:0061351	75	0.532	Zebrafish Rat
negative regulation of mitotic anaphase promoting complex activity	GO:0060564	2	0.531
regulation of cellular protein metabolic process	GO:0032268	243	0.529
positive regulation of neurogenesis	GO:0050769	41	0.527	Mouse Rat
juvenile hormone mediated signaling pathway	GO:0035626	3	0.514
formation of primary germ layer	GO:0001704	24	0.513	Zebrafish
gtp catabolic process	GO:0006184	72	0.512
negative regulation of signaling	GO:0023057	219	0.512	Mouse
sensory organ precursor cell fate determination	GO:0016360	19	0.510
axonogenesis	GO:0007409	290	0.506
positive regulation of transcription involved in g2 m transition of mitotic cell cycle	GO:0090282	1	0.500
maintenance of blood brain barrier	GO:0035633	1	0.498	Zebrafish
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.497
negative regulation of cell development	GO:0010721	62	0.496
positive regulation of chromatin silencing at telomere	GO:0031940	2	0.486
instar larval development	GO:0002168	55	0.485
negative regulation of terminal cell fate specification open tracheal system	GO:0035155	2	0.476
positive regulation of rna metabolic process	GO:0051254	271	0.473
negative regulation of cell fate specification	GO:0009996	15	0.471
negative regulation of heart induction by canonical wnt signaling pathway	GO:0003136	3	0.458
positive regulation of macromolecule metabolic process	GO:0010604	405	0.458
hindgut development	GO:0061525	58	0.455
regulation of cell projection organization	GO:0031344	92	0.455
body morphogenesis	GO:0010171	2	0.452	Zebrafish Worm
meiotic spindle checkpoint	GO:0044779	1	0.449
mesenchymal cell development	GO:0014031	1	0.446	Human Mouse
striated muscle cell differentiation	GO:0051146	90	0.445	Human Mouse
spermatogenesis	GO:0007283	200	0.444	Rat
negative regulation of eye photoreceptor cell development	GO:0042480	3	0.442
dna templated transcriptional start site selection	GO:0001173	1	0.438
negative regulation of compound eye photoreceptor development	GO:0045316	3	0.436
regulation of axonogenesis	GO:0050770	32	0.433
p granule organization	GO:0030719	4	0.431
chemosensory behavior	GO:0007635	106	0.431
homophilic cell adhesion via plasma membrane adhesion molecules	GO:0007156	18	0.430
taxis	GO:0042330	304	0.423
imaginal disc derived wing morphogenesis	GO:0007476	337	0.421
cell type specific apoptotic process	GO:0097285	38	0.421
developmental pigmentation	GO:0048066	68	0.413
death	GO:0016265	284	0.411	Human Mouse
peripheral nervous system development	GO:0007422	52	0.411
posttranscriptional regulation of gene expression	GO:0010608	145	0.403
specification of segmental identity antennal segment	GO:0007383	2	0.399
negative regulation of rna metabolic process	GO:0051253	251	0.399	Mouse
negative regulation of dna templated transcription initiation	GO:2000143	1	0.398
regulation of ran gtpase activity	GO:0032316	1	0.395
regulation of cell fate commitment	GO:0010453	29	0.394
positive regulation of muscle organ development	GO:0048636	6	0.390	Mouse
single organism cell adhesion	GO:0098602	47	0.390
striated muscle cell development	GO:0055002	50	0.385	Human
regulation of epithelial cell migration	GO:0010632	12	0.375	Human
stem cell proliferation	GO:0072089	88	0.372	Rat
regulation of heart induction	GO:0090381	3	0.369
mesodermal cell fate commitment	GO:0001710	7	0.368	Zebrafish
response to other organism	GO:0051707	293	0.367
larval lymph gland hemopoiesis	GO:0035167	17	0.367
negative regulation of transcription initiation from rna polymerase ii promoter	GO:0060633	1	0.362
regulation of cell development	GO:0060284	215	0.360
learning	GO:0007612	75	0.360
negative regulation of mrna 3 end processing	GO:0031441	3	0.358
regulation of protein catabolic process	GO:0042176	55	0.358
negative regulation of epithelial cell migration	GO:0010633	1	0.355	Human
negative regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator	GO:1902166	1	0.354
positive regulation of gtpase activity	GO:0043547	43	0.354
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.353
protein import into nucleus	GO:0006606	51	0.352
positive regulation of catalytic activity	GO:0043085	118	0.351
response to radiation	GO:0009314	155	0.349
chromosome segregation	GO:0007059	157	0.348
dna integration	GO:0015074	1	0.348
epidermal cell differentiation	GO:0009913	51	0.347	Mouse
epidermis development	GO:0008544	65	0.346	Mouse
lateral inhibition	GO:0046331	206	0.343
regulation of synapse assembly	GO:0051963	94	0.340
septin ring organization	GO:0031106	1	0.339
pigmentation	GO:0043473	75	0.337
regulation of trichome morphogenesis	GO:2000039	3	0.334
organophosphate metabolic process	GO:0019637	195	0.334
wnt signaling pathway	GO:0016055	98	0.332	Mouse
regulation of anatomical structure size	GO:0090066	163	0.330	Zebrafish
nucleoside phosphate metabolic process	GO:0006753	162	0.330
macromolecular complex assembly	GO:0065003	256	0.328
tube morphogenesis	GO:0035239	191	0.328
cuticle pattern formation	GO:0035017	27	0.326
nurse cell nucleus anchoring	GO:0007302	1	0.325
cellular response to oxygen containing compound	GO:1901701	79	0.322
purine containing compound metabolic process	GO:0072521	155	0.318
heart development	GO:0007507	82	0.317
regulation of organ morphogenesis	GO:2000027	78	0.317
regulation of proteasomal protein catabolic process	GO:0061136	39	0.317
negative regulation of cellular biosynthetic process	GO:0031327	277	0.315	Mouse
kidney development	GO:0001822	3	0.315	Zebrafish Mouse
negative regulation of transcription from rna polymerase iii promoter	GO:0016480	2	0.313
oviposition	GO:0018991	19	0.310	Worm
negative regulation of sister chromatid cohesion	GO:0045875	1	0.310
spinal cord dorsal ventral patterning	GO:0021513	1	0.308
macromolecule catabolic process	GO:0009057	161	0.308
response to hypoxia	GO:0001666	53	0.307	Mouse
cellular response to organic substance	GO:0071310	132	0.307	Human
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycle	GO:0051436	2	0.305
asymmetric protein localization	GO:0008105	33	0.305
cellular protein localization	GO:0034613	160	0.300
neuroblast fate determination	GO:0007400	12	0.299
regulation of cell fate specification	GO:0042659	27	0.299
negative regulation of notch signaling pathway	GO:0045746	41	0.299
carbohydrate derivative metabolic process	GO:1901135	217	0.298
protein catabolic process	GO:0030163	101	0.297
trachea development	GO:0060438	29	0.296
cytoplasmic sequestering of nf kappab	GO:0007253	1	0.294
malpighian tubule morphogenesis	GO:0007443	44	0.294
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0017055	1	0.291
establishment of organelle localization	GO:0051656	122	0.290
muscle organ development	GO:0007517	127	0.289
release of cytoplasmic sequestered nf kappab	GO:0008588	1	0.285
positive regulation of protein modification process	GO:0031401	58	0.284
regulation of hematopoietic stem cell differentiation	GO:1902036	1	0.282
regulation of protein metabolic process	GO:0051246	256	0.280
neuroblast proliferation	GO:0007405	74	0.278	Rat
negative regulation of signal transduction	GO:0009968	206	0.278	Mouse
meiotic dna repair synthesis	GO:0000711	3	0.276
regulation of muscle organ development	GO:0048634	13	0.274	Human Mouse
hematopoietic or lymphoid organ development	GO:0048534	57	0.273
actin filament bundle assembly	GO:0051017	26	0.271
cell morphogenesis involved in malpighian tubule morphogenesis	GO:0061336	1	0.269
homeostatic process	GO:0042592	199	0.269
single organismal cell cell adhesion	GO:0016337	45	0.266
positive regulation of cell maturation	GO:1903431	2	0.259
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.258
purine ribonucleotide catabolic process	GO:0009154	109	0.258
maintenance of chromatin silencing	GO:0006344	0	0.257
positive regulation of pole plasm oskar mrna localization	GO:0045856	2	0.256
stress granule disassembly	GO:0035617	1	0.254
regulation of phosphorus metabolic process	GO:0051174	210	0.252
intracellular transport	GO:0046907	228	0.251
regulation of protein phosphorylation	GO:0001932	64	0.246
regulation of synaptic transmission	GO:0050804	69	0.245
ribonucleotide catabolic process	GO:0009261	109	0.244
neuroblast fate commitment	GO:0014017	19	0.244
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.243	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.243	Mouse
protein transport	GO:0015031	155	0.242	Mouse
establishment of protein localization	GO:0045184	163	0.242	Mouse
positive regulation of cellular catabolic process	GO:0031331	95	0.241
oocyte nucleus migration involved in oocyte dorsal ventral axis specification	GO:0007312	4	0.241
nuclear axial expansion	GO:0035191	3	0.239
response to biotic stimulus	GO:0009607	294	0.239
response to red light	GO:0010114	2	0.239
positive regulation of viral entry into host cell	GO:0046598	2	0.239
compound eye cone cell differentiation	GO:0042675	13	0.236
regulation of synapse structure and activity	GO:0050803	128	0.236
protein modification by small protein conjugation or removal	GO:0070647	106	0.235
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.235
positive regulation of insulin like growth factor receptor signaling pathway	GO:0043568	2	0.232
positive regulation of synaptic vesicle exocytosis	GO:2000302	1	0.229
protein phosphorylation	GO:0006468	169	0.225
germarium derived cystoblast division	GO:0048142	3	0.224
ribonucleoside metabolic process	GO:0009119	127	0.224
regulation of viral entry into host cell	GO:0046596	2	0.223
centripetally migrating follicle cell migration	GO:0060269	1	0.222
border follicle cell migration	GO:0007298	113	0.221
fatty acid derivative biosynthetic process	GO:1901570	1	0.220
microtubule sliding	GO:0051012	3	0.220
regulation of nuclear division	GO:0051783	58	0.220	Worm
maintenance of sister chromatid cohesion	GO:0034086	1	0.220
regulation of chromosome condensation	GO:0060623	1	0.220
stomatogastric nervous system development	GO:0007421	2	0.217
glycosyl compound catabolic process	GO:1901658	112	0.214
organelle assembly	GO:0070925	198	0.213
ganglion mother cell fate determination	GO:0007402	2	0.212
negative regulation of nurse cell apoptotic process	GO:0045849	2	0.210
small gtpase mediated signal transduction	GO:0007264	88	0.206	Human
nucleobase containing compound catabolic process	GO:0034655	165	0.206
regulation of transcription involved in g2 m transition of mitotic cell cycle	GO:0000117	1	0.205
asymmetric neuroblast division resulting in ganglion mother cell formation	GO:0055060	2	0.204
organ growth	GO:0035265	56	0.204	Mouse
compound eye retinal cell programmed cell death	GO:0046667	23	0.202
nucleotide catabolic process	GO:0009166	109	0.198
actin cytoskeleton organization	GO:0030036	206	0.193
glial cell differentiation	GO:0010001	35	0.192
positive regulation of gliogenesis	GO:0014015	5	0.189	Mouse Rat
anterior posterior axis specification follicular epithelium	GO:0030714	2	0.189
ribonucleoprotein complex disassembly	GO:0032988	1	0.187
negative regulation of meiotic cell cycle phase transition	GO:1901994	1	0.186
regulation of rap gtpase activity	GO:0032317	3	0.185
somatic stem cell maintenance	GO:0035019	14	0.185	Zebrafish
trichome morphogenesis	GO:0010090	3	0.184

N disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
heart disease	DOID:114	0.451	Human
heart valve disease	DOID:4079	0.451	Human
disease of anatomical entity	DOID:7	0.451	Human
cardiovascular system disease	DOID:1287	0.451	Human
aortic valve disease	DOID:62	0.451	Human
organ system benign neoplasm	DOID:0060085	0.427
pilomatrixoma	DOID:5374	0.427
hair follicle neoplasm	DOID:5375	0.427
benign neoplasm	DOID:0060072	0.427
disease of cellular proliferation	DOID:14566	0.427
skin benign neoplasm	DOID:3165	0.427
integumentary system benign neoplasm	DOID:0060121	0.427
myopathy	DOID:423	0.398
muscular disease	DOID:0080000	0.398
cardiomyopathy	DOID:0050700	0.398
intrinsic cardiomyopathy	DOID:0060036	0.398
arrhythmogenic right ventricular cardiomyopathy	DOID:0050431	0.398
musculoskeletal system disease	DOID:17	0.398
muscle tissue disease	DOID:66	0.398
hepatobiliary disease	DOID:3118	0.339	Human
gastrointestinal system disease	DOID:77	0.339	Human
liver disease	DOID:409	0.339	Human
alagille syndrome	DOID:9245	0.339	Human
artery disease	DOID:0050828	0.337
vascular disease	DOID:178	0.337
aortic disease	DOID:520	0.337
costello syndrome	DOID:0050469	0.301
leopard syndrome	DOID:14291	0.291
disease of metabolism	DOID:0014667	0.291
hemochromatosis	DOID:2352	0.291
inherited metabolic disorder	DOID:655	0.291
metal metabolism disorder	DOID:896	0.291
familial meningioma	DOID:4586	0.285
nervous system cancer	DOID:3093	0.285
central nervous system cancer	DOID:3620	0.285
cancer	DOID:162	0.285
organ system cancer	DOID:0050686	0.285
meningioma	DOID:3565	0.285
hajdu cheney syndrome	DOID:2736	0.271	Human
aortic valve stenosis	DOID:1712	0.258	Human
female reproductive system disease	DOID:229	0.258
ovarian disease	DOID:1100	0.258
reproductive system disease	DOID:15	0.258
premature ovarian failure	DOID:5426	0.258
nervous system benign neoplasm	DOID:0060115	0.223
immune system cancer	DOID:0060083	0.201
hematologic cancer	DOID:2531	0.201
bone marrow cancer	DOID:4960	0.201

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