IMP: Integrative Multi-species Prediction

Drosophila melanogaster

329 known processes

CycE (Dmel_CG3938)

Cyclin E

(Aliases: cyclinE,fond,CyclE,l(2)05206,CYCE,cdi7,br37,DmcyclinE,cycline,dm-cycE,CyeE,l(2)k05007,BG:DS07108.3,l(2)br37,DmCycE,l35Dd,l(2)35Dd,3938,l(2)k02602,l(2)k02514,CG3938,CDI7,DmcycE,Dmel\CG3938,Cyc E,cycE,Cdi7,D-CycE)

FLYBASE: FBgn0010382
Entrez: 34924
UniProtKB: A4V0R4
UniProtKB: P54733
UniProtKB: M9NDQ2

Process Predictions
Disease Predictions

CycE biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
meiotic chromosome segregation	GO:0045132	59	0.998
meiosis i	GO:0007127	59	0.995
spindle organization	GO:0007051	253	0.995
meiotic cell cycle process	GO:1903046	132	0.992
centrosome cycle	GO:0007098	137	0.991
chorion containing eggshell formation	GO:0007304	105	0.985
positive regulation of mitotic cell cycle	GO:0045931	34	0.976
meiotic nuclear division	GO:0007126	151	0.968
chromosome segregation	GO:0007059	157	0.966
cellular component assembly involved in morphogenesis	GO:0010927	151	0.949
epithelial cell differentiation	GO:0030855	322	0.948
positive regulation of macromolecule metabolic process	GO:0010604	405	0.941
organelle fission	GO:0048285	340	0.938
oocyte maturation	GO:0001556	3	0.930
ovarian follicle cell development	GO:0030707	248	0.929
eggshell chorion assembly	GO:0007306	66	0.928
eggshell formation	GO:0030703	105	0.923
epithelial cell development	GO:0002064	274	0.918
regulation of cell cycle process	GO:0010564	181	0.916
cell motility	GO:0048870	251	0.915
chromosome separation	GO:0051304	42	0.903
nuclear division	GO:0000280	332	0.897
male meiosis	GO:0007140	52	0.896
male gamete generation	GO:0048232	201	0.888
mitotic spindle organization	GO:0007052	220	0.859
positive regulation of cellular protein metabolic process	GO:0032270	118	0.857
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.851
regulation of cellular protein metabolic process	GO:0032268	243	0.845
response to other organism	GO:0051707	293	0.842
columnar cuboidal epithelial cell development	GO:0002066	249	0.827
regulation of nervous system development	GO:0051960	248	0.826
stem cell maintenance	GO:0019827	67	0.818
chromosome organization	GO:0051276	360	0.817
regulation of defense response	GO:0031347	102	0.811
negative regulation of cellular metabolic process	GO:0031324	382	0.798
cell fate determination	GO:0001709	91	0.782
protein complex biogenesis	GO:0070271	201	0.781
cell cycle g1 s phase transition	GO:0044843	31	0.771
regulation of cell division	GO:0051302	72	0.735
sensory organ precursor cell division	GO:0045035	10	0.719
tube morphogenesis	GO:0035239	191	0.717
cellular protein complex assembly	GO:0043623	71	0.715
regulation of mitotic cell cycle	GO:0007346	190	0.712
protein complex assembly	GO:0006461	200	0.685
mitotic cell cycle phase transition	GO:0044772	138	0.678
asymmetric cell division	GO:0008356	37	0.664
meiotic cell cycle	GO:0051321	171	0.662	Worm
localization of cell	GO:0051674	257	0.660
spermatogenesis	GO:0007283	200	0.644
macromolecular complex assembly	GO:0065003	256	0.637
germarium derived oocyte fate determination	GO:0007294	26	0.615
regulation of cell cycle phase transition	GO:1901987	130	0.607
ubiquitin dependent protein catabolic process	GO:0006511	78	0.585
reproductive behavior	GO:0019098	122	0.581
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.576
organelle assembly	GO:0070925	198	0.574
protein catabolic process	GO:0030163	101	0.562
positive regulation of protein metabolic process	GO:0051247	128	0.561
regulation of dna metabolic process	GO:0051052	34	0.551
organic substance catabolic process	GO:1901575	308	0.551
regulation of developmental growth	GO:0048638	174	0.543
chromatin assembly or disassembly	GO:0006333	52	0.532
regulation of protein kinase activity	GO:0045859	51	0.528
cell junction assembly	GO:0034329	42	0.518
apoptotic process	GO:0006915	159	0.515
proteolysis	GO:0006508	192	0.514
respiratory system development	GO:0060541	213	0.509
appendage development	GO:0048736	401	0.497
negative regulation of mitotic cell cycle	GO:0045930	109	0.491
negative regulation of cell cycle	GO:0045786	116	0.470
sister chromatid segregation	GO:0000819	92	0.463
membrane disassembly	GO:0030397	4	0.455
protein phosphorylation	GO:0006468	169	0.453
syncytial blastoderm mitotic cell cycle	GO:0035186	21	0.451
dorsal appendage formation	GO:0046843	47	0.445
regulation of molecular function	GO:0065009	217	0.442
response to biotic stimulus	GO:0009607	294	0.433
dna replication	GO:0006260	48	0.431
negative regulation of cell cycle phase transition	GO:1901988	103	0.425
regulation of meiosis	GO:0040020	3	0.422
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.421
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.421
growth	GO:0040007	359	0.418	Rat
eggshell chorion gene amplification	GO:0007307	9	0.412
centrosome duplication	GO:0051298	121	0.405
negative regulation of neuroblast proliferation	GO:0007406	27	0.403
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.403
female meiosis i	GO:0007144	8	0.403
neuroblast fate commitment	GO:0014017	19	0.400
positive regulation of catalytic activity	GO:0043085	118	0.393
regulation of phosphate metabolic process	GO:0019220	210	0.393
cellular protein modification process	GO:0006464	438	0.387
cellular protein catabolic process	GO:0044257	83	0.386
developmental growth	GO:0048589	280	0.384	Rat
morphogenesis of an epithelium	GO:0002009	276	0.381
tissue migration	GO:0090130	155	0.377
neuroblast differentiation	GO:0014016	29	0.372
modification dependent macromolecule catabolic process	GO:0043632	79	0.365
post embryonic appendage morphogenesis	GO:0035120	385	0.365
positive regulation of molecular function	GO:0044093	136	0.364
regulation of phosphorus metabolic process	GO:0051174	210	0.353
cell division	GO:0051301	248	0.344
multicellular organism growth	GO:0035264	46	0.343
death	GO:0016265	284	0.343
germarium derived egg chamber formation	GO:0007293	101	0.323
mitotic nuclear division	GO:0007067	213	0.317
regulation of catalytic activity	GO:0050790	185	0.315
regulation of mitosis	GO:0007088	56	0.315
organophosphate metabolic process	GO:0019637	195	0.303
mitotic sister chromatid separation	GO:0051306	30	0.299
cell proliferation	GO:0008283	299	0.288
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.287
protein modification process	GO:0036211	438	0.286
mitotic cell cycle embryonic	GO:0045448	38	0.283
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.272
regulation of protein metabolic process	GO:0051246	256	0.271
larval development	GO:0002164	104	0.267	Worm
cellular catabolic process	GO:0044248	372	0.267
intracellular signal transduction	GO:0035556	300	0.266
cell cycle dna replication	GO:0044786	23	0.264	Worm
regulation of catabolic process	GO:0009894	170	0.256
actin filament based process	GO:0030029	220	0.255
imaginal disc derived wing morphogenesis	GO:0007476	337	0.252
tissue morphogenesis	GO:0048729	297	0.251
regulation of cell proliferation	GO:0042127	163	0.241
regulation of multicellular organismal development	GO:2000026	414	0.232	Worm
response to ionizing radiation	GO:0010212	32	0.231
mitotic sister chromatid segregation	GO:0000070	87	0.231
single organism catabolic process	GO:0044712	228	0.229
cell migration	GO:0016477	238	0.229
regulation of protein modification process	GO:0031399	112	0.227
regulation of transferase activity	GO:0051338	58	0.226
regulation of cell morphogenesis	GO:0022604	163	0.214
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.210
cystoblast division	GO:0007282	10	0.204
convergent extension	GO:0060026	2	0.202
intracellular transport	GO:0046907	228	0.199
regulation of cell cycle	GO:0051726	291	0.199
dna conformation change	GO:0071103	105	0.193
dna endoreduplication	GO:0042023	22	0.192	Worm
stem cell fate determination	GO:0048867	15	0.191
cell cycle phase transition	GO:0044770	140	0.190
catabolic process	GO:0009056	409	0.187
chromatin organization	GO:0006325	207	0.187
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.186
organ growth	GO:0035265	56	0.183
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.182
actin cytoskeleton organization	GO:0030036	206	0.181
malpighian tubule development	GO:0072002	64	0.179
epithelial cell migration open tracheal system	GO:0007427	32	0.179
branching involved in open tracheal system development	GO:0060446	45	0.178
regulation of hydrolase activity	GO:0051336	97	0.176
positive regulation of cell cycle process	GO:0090068	28	0.175
response to inorganic substance	GO:0010035	44	0.175
regulation of sister chromatid cohesion	GO:0007063	2	0.174
positive regulation of proteolysis	GO:0045862	52	0.169
regulation of organ growth	GO:0046620	42	0.169
single organism intracellular transport	GO:1902582	207	0.169
programmed cell death	GO:0012501	257	0.166
developmental programmed cell death	GO:0010623	138	0.165
histoblast morphogenesis	GO:0007488	9	0.164
renal tubule development	GO:0061326	64	0.163
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.158
negative regulation of cell differentiation	GO:0045596	143	0.156
multi multicellular organism process	GO:0044706	123	0.154
protein localization to organelle	GO:0033365	82	0.151
germarium derived female germ line cyst formation	GO:0030727	42	0.149
regulation of epidermal cell differentiation	GO:0045604	3	0.146
positive regulation of developmental process	GO:0051094	143	0.145	Rat Worm
chromosome condensation	GO:0030261	41	0.141
positive regulation of growth	GO:0045927	75	0.140
axon development	GO:0061564	297	0.139
regulation of cytoskeleton organization	GO:0051493	89	0.137
protein localization to nucleus	GO:0034504	55	0.130
ovarian follicle cell migration	GO:0007297	121	0.129
cytokinesis	GO:0000910	90	0.128
response to abiotic stimulus	GO:0009628	341	0.127
homeostatic process	GO:0042592	199	0.126
negative regulation of mitotic sister chromatid separation	GO:2000816	13	0.126
dna packaging	GO:0006323	91	0.126
response to radiation	GO:0009314	155	0.125
reproductive system development	GO:0061458	74	0.125	Rat Worm
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.123
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.123
defense response to other organism	GO:0098542	225	0.123
g2 m transition of mitotic cell cycle	GO:0000086	19	0.122
regulation of proteolysis	GO:0030162	87	0.117
regulation of imaginal disc derived wing size	GO:0044719	20	0.116
stem cell proliferation	GO:0072089	88	0.115
histone modification	GO:0016570	106	0.115
regulation of anatomical structure morphogenesis	GO:0022603	242	0.115
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.113
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.113
positive regulation of protein modification process	GO:0031401	58	0.113
nuclear envelope organization	GO:0006998	7	0.112
positive regulation of r7 cell differentiation	GO:0045678	7	0.111
immune system process	GO:0002376	347	0.111
cell death	GO:0008219	279	0.110
protein ubiquitination	GO:0016567	70	0.108
positive regulation of multicellular organism growth	GO:0040018	21	0.107
regulation of protein phosphorylation	GO:0001932	64	0.107
regulation of growth	GO:0040008	233	0.105
cell cell junction organization	GO:0045216	55	0.104
adherens junction assembly	GO:0034333	11	0.103
protein localization	GO:0008104	284	0.102
wing disc morphogenesis	GO:0007472	344	0.101
germarium derived female germ line cyst encapsulation	GO:0030708	8	0.101
regulation of neuroblast proliferation	GO:1902692	34	0.100
ameboidal type cell migration	GO:0001667	151	0.100
brain development	GO:0007420	120	0.099
positive regulation of phosphorylation	GO:0042327	87	0.098
wnt signaling pathway	GO:0016055	98	0.097	Mouse
axonogenesis	GO:0007409	290	0.096
positive regulation of mitotic sister chromatid separation	GO:1901970	10	0.096
meiotic chromosome condensation	GO:0010032	3	0.096
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.094
female germ line cyst formation	GO:0048135	42	0.093
compound eye retinal cell programmed cell death	GO:0046667	23	0.092
adherens junction organization	GO:0034332	27	0.092
phosphorylation	GO:0016310	294	0.090
regulation of epithelial cell differentiation	GO:0030856	4	0.090
centrosome organization	GO:0051297	163	0.090
vesicle mediated transport	GO:0016192	381	0.087
immune response	GO:0006955	246	0.087
proteasomal protein catabolic process	GO:0010498	59	0.087
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.086
negative regulation of cellular catabolic process	GO:0031330	34	0.085
renal tubule morphogenesis	GO:0061333	44	0.085
response to external biotic stimulus	GO:0043207	293	0.084
response to oxygen containing compound	GO:1901700	200	0.083	Rat
cell junction organization	GO:0034330	57	0.082
imaginal disc derived appendage development	GO:0048737	399	0.082
defense response	GO:0006952	300	0.080
regulation of dna replication	GO:0006275	13	0.079
positive regulation of protein kinase activity	GO:0045860	25	0.079
branch fusion open tracheal system	GO:0035147	17	0.078
mitotic cytokinesis	GO:0000281	50	0.078
cellular protein localization	GO:0034613	160	0.077
appendage morphogenesis	GO:0035107	397	0.075
response to extracellular stimulus	GO:0009991	116	0.075	Rat
negative regulation of mitotic anaphase promoting complex activity	GO:0060564	2	0.075
stem cell differentiation	GO:0048863	117	0.075
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.075
regulation of photoreceptor cell differentiation	GO:0046532	34	0.074
negative regulation of rna biosynthetic process	GO:1902679	240	0.074
cellular macromolecule catabolic process	GO:0044265	136	0.073
positive regulation of protein phosphorylation	GO:0001934	34	0.073
regulation of protein catabolic process	GO:0042176	55	0.073
cellular macromolecular complex assembly	GO:0034622	153	0.073
cell cycle checkpoint	GO:0000075	95	0.072
malpighian tubule morphogenesis	GO:0007443	44	0.072
negative regulation of developmental growth	GO:0048640	64	0.072
positive regulation of developmental growth	GO:0048639	62	0.071
regulation of neurogenesis	GO:0050767	158	0.070
epidermal cell differentiation	GO:0009913	51	0.070
digestive system development	GO:0055123	149	0.069
muscle structure development	GO:0061061	224	0.068
antimicrobial humoral response	GO:0019730	99	0.066
tube fusion	GO:0035146	17	0.065
inter male aggressive behavior	GO:0002121	60	0.065
muscle organ development	GO:0007517	127	0.065
dna biosynthetic process	GO:0071897	24	0.064
response to organic substance	GO:0010033	284	0.064	Rat
hindgut development	GO:0061525	58	0.063
regulation of malpighian tubule diameter	GO:0035297	3	0.062
hematopoietic or lymphoid organ development	GO:0048534	57	0.060
gonad development	GO:0008406	50	0.059	Rat Worm
positive regulation of cell communication	GO:0010647	250	0.059
germ line cyst formation	GO:0048134	44	0.057
multicellular organismal reproductive behavior	GO:0033057	110	0.056
oocyte differentiation	GO:0009994	145	0.055
dorsal closure	GO:0007391	79	0.055
regulation of multicellular organism growth	GO:0040014	40	0.054
developmental growth involved in morphogenesis	GO:0060560	65	0.054
positive regulation of phosphorus metabolic process	GO:0010562	139	0.054
negative regulation of wnt signaling pathway	GO:0030178	28	0.052
ribose phosphate metabolic process	GO:0019693	145	0.052
tube development	GO:0035295	244	0.051
dendrite development	GO:0016358	204	0.049
positive regulation of hydrolase activity	GO:0051345	78	0.048
negative regulation of biosynthetic process	GO:0009890	277	0.047
positive regulation of catabolic process	GO:0009896	105	0.047
single organism biosynthetic process	GO:0044711	206	0.046
epithelial cell migration	GO:0010631	148	0.046
head involution	GO:0008258	35	0.046
morphogenesis of a branching structure	GO:0001763	45	0.046
forebrain development	GO:0030900	2	0.045
gland development	GO:0048732	191	0.045	Rat
development of primary sexual characteristics	GO:0045137	50	0.045	Rat Worm
negative regulation of cellular protein metabolic process	GO:0032269	85	0.045
cellular component disassembly	GO:0022411	46	0.045
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.045
purine containing compound metabolic process	GO:0072521	155	0.045
germ line stem cell division	GO:0042078	25	0.044
salivary gland morphogenesis	GO:0007435	145	0.044
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.044
compound eye photoreceptor development	GO:0042051	78	0.044
glial cell differentiation	GO:0010001	35	0.044
ribonucleoside catabolic process	GO:0042454	112	0.043
neural precursor cell proliferation	GO:0061351	75	0.043
positive regulation of phosphate metabolic process	GO:0045937	139	0.042
mrna processing	GO:0006397	104	0.042
modification dependent protein catabolic process	GO:0019941	78	0.042
glial cell fate determination	GO:0007403	3	0.042
eye development	GO:0001654	323	0.041
gliogenesis	GO:0042063	80	0.041
g1 s transition of mitotic cell cycle	GO:0000082	31	0.041
fusome organization	GO:0045478	13	0.041
synaptonemal complex organization	GO:0070193	5	0.040
small gtpase mediated signal transduction	GO:0007264	88	0.040
regulation of immune system process	GO:0002682	176	0.039
female meiosis chromosome segregation	GO:0016321	33	0.039
negative regulation of mitotic sister chromatid segregation	GO:0033048	13	0.039
axon guidance	GO:0007411	233	0.039
negative regulation of molecular function	GO:0044092	51	0.038
neuroblast fate determination	GO:0007400	12	0.038
negative regulation of developmental process	GO:0051093	201	0.038
regulation of cell differentiation	GO:0045595	302	0.038
compound eye cone cell differentiation	GO:0042675	13	0.038
microtubule organizing center organization	GO:0031023	168	0.037
oocyte development	GO:0048599	124	0.037
negative regulation of protein metabolic process	GO:0051248	85	0.037
chromatin assembly	GO:0031497	48	0.037
defense response to bacterium	GO:0042742	178	0.036
hindgut morphogenesis	GO:0007442	58	0.036
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.036
negative regulation of cellular biosynthetic process	GO:0031327	277	0.036
somatic muscle development	GO:0007525	66	0.036
negative regulation of protein processing	GO:0010955	31	0.036
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.036
specification of organ identity	GO:0010092	3	0.036
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.035
regulation of cell death	GO:0010941	173	0.035
nucleoside phosphate metabolic process	GO:0006753	162	0.035
regulation of cellular protein catabolic process	GO:1903362	44	0.035
cellular response to external stimulus	GO:0071496	66	0.035	Rat
positive regulation of nucleotide metabolic process	GO:0045981	55	0.034
regulation of cytokinesis	GO:0032465	3	0.034
negative regulation of neurogenesis	GO:0050768	53	0.033
gastrulation	GO:0007369	70	0.033
mitotic cell cycle checkpoint	GO:0007093	88	0.033
protein import into nucleus	GO:0006606	51	0.033
open tracheal system development	GO:0007424	204	0.033
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.033
cellular response to dna damage stimulus	GO:0006974	223	0.033
dendrite morphogenesis	GO:0048813	199	0.033
carbohydrate derivative catabolic process	GO:1901136	118	0.033
cell cycle arrest	GO:0007050	4	0.033	Worm
specification of axis polarity	GO:0065001	6	0.033
regulation of kinase activity	GO:0043549	53	0.032
convergent extension involved in gastrulation	GO:0060027	2	0.032
regulation of immune response	GO:0050776	118	0.032
head development	GO:0060322	135	0.032
purine containing compound catabolic process	GO:0072523	112	0.031
rna processing	GO:0006396	147	0.031
neuron projection guidance	GO:0097485	241	0.031
protein modification by small protein conjugation	GO:0032446	79	0.031
epithelium migration	GO:0090132	148	0.031
mushroom body development	GO:0016319	70	0.031
regulation of intracellular transport	GO:0032386	64	0.030
response to oxidative stress	GO:0006979	86	0.030
protein modification by small protein conjugation or removal	GO:0070647	106	0.030
negative regulation of meiotic cell cycle	GO:0051447	2	0.030
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.029
regulation of r7 cell differentiation	GO:0045676	15	0.029
positive regulation of ras gtpase activity	GO:0032320	36	0.029
single organism behavior	GO:0044708	391	0.029
chaeta development	GO:0022416	97	0.028
endocytosis	GO:0006897	310	0.028
cognition	GO:0050890	141	0.028
digestive tract morphogenesis	GO:0048546	127	0.028
glial cell migration	GO:0008347	31	0.027
chitin based cuticle development	GO:0040003	49	0.027
regulation of organelle organization	GO:0033043	196	0.027
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.027
positive regulation of cellular catabolic process	GO:0031331	95	0.027
cell proliferation involved in compound eye morphogenesis	GO:0035736	4	0.026
cellular macromolecule localization	GO:0070727	220	0.026
cytoplasmic transport	GO:0016482	130	0.026
ribonucleotide catabolic process	GO:0009261	109	0.026
regulation of neural precursor cell proliferation	GO:2000177	35	0.026
regulation of anatomical structure size	GO:0090066	163	0.025
mitotic dna damage checkpoint	GO:0044773	74	0.025
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.025
negative regulation of stem cell proliferation	GO:2000647	30	0.025
regulation of ras gtpase activity	GO:0032318	38	0.025
regulation of innate immune response	GO:0045088	71	0.025
regulation of cellular localization	GO:0060341	136	0.025
response to ketone	GO:1901654	34	0.025	Rat
tendon development	GO:0035989	1	0.025
negative regulation of gene expression epigenetic	GO:0045814	77	0.025
organophosphate catabolic process	GO:0046434	112	0.024
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.024
rna splicing	GO:0008380	83	0.024
organelle inheritance	GO:0048308	2	0.024
protein targeting	GO:0006605	64	0.024
meiotic spindle organization	GO:0000212	36	0.024
negative regulation of cyclin dependent protein serine threonine kinase activity	GO:0045736	1	0.024
positive regulation of gene expression	GO:0010628	290	0.023
central nervous system development	GO:0007417	201	0.023
oocyte morphogenesis	GO:0048601	3	0.023
negative regulation of defense response	GO:0031348	35	0.023
regulation of phosphatase activity	GO:0010921	3	0.023
establishment of localization in cell	GO:0051649	402	0.023
ras protein signal transduction	GO:0007265	88	0.022
positive regulation of cell cycle	GO:0045787	43	0.022
morphogenesis of follicular epithelium	GO:0016333	36	0.022
regulation of nuclear division	GO:0051783	58	0.022
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.022
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.022
regulation of phosphorylation	GO:0042325	147	0.022
cellular respiration	GO:0045333	26	0.022
anatomical structure homeostasis	GO:0060249	97	0.022
regulation of exit from mitosis	GO:0007096	7	0.022
cellular lipid metabolic process	GO:0044255	83	0.021
neuroblast proliferation	GO:0007405	74	0.021
dorsal ventral pattern formation	GO:0009953	133	0.021
positive regulation of cell cycle g2 m phase transition	GO:1902751	2	0.021
fusion cell fate specification	GO:0035156	4	0.021
organonitrogen compound metabolic process	GO:1901564	318	0.020
determination of adult lifespan	GO:0008340	137	0.020
cell aging	GO:0007569	2	0.020
negative regulation of cell cycle process	GO:0010948	109	0.020
spindle assembly involved in female meiosis	GO:0007056	14	0.020
regeneration	GO:0031099	16	0.020	Rat
positive regulation of rna metabolic process	GO:0051254	271	0.019
chromosome organization involved in meiosis	GO:0070192	10	0.019
positive regulation of kinase activity	GO:0033674	25	0.019
regulation of mitotic sister chromatid separation	GO:0010965	28	0.019
nucleobase containing compound catabolic process	GO:0034655	165	0.019
regulation of chromosome organization	GO:0033044	64	0.019
positive regulation of signal transduction	GO:0009967	223	0.019
regulation of cellular catabolic process	GO:0031329	157	0.019
regulation of stem cell proliferation	GO:0072091	40	0.019
regulation of cell fate commitment	GO:0010453	29	0.018
imaginal disc derived wing vein specification	GO:0007474	48	0.018
body morphogenesis	GO:0010171	2	0.018	Worm
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.018
regulation of developmental pigmentation	GO:0048070	24	0.018
protein transport	GO:0015031	155	0.018
spindle assembly involved in meiosis	GO:0090306	20	0.018
epithelial tube morphogenesis	GO:0060562	88	0.018
dna metabolic process	GO:0006259	227	0.018
sister chromatid cohesion	GO:0007062	18	0.018
negative regulation of cellular component organization	GO:0051129	108	0.018
immune system development	GO:0002520	57	0.018
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.018
cellular nitrogen compound catabolic process	GO:0044270	165	0.017
cellular response to extracellular stimulus	GO:0031668	64	0.017	Rat
mesoderm development	GO:0007498	78	0.017
peptidyl tyrosine phosphorylation	GO:0018108	24	0.017
regulation of response to external stimulus	GO:0032101	115	0.017
stem cell division	GO:0017145	69	0.017
negative regulation of gene expression	GO:0010629	387	0.017
response to temperature stimulus	GO:0009266	106	0.017
multicellular organismal aging	GO:0010259	140	0.017
eye antennal disc development	GO:0035214	60	0.017
negative regulation of catalytic activity	GO:0043086	42	0.017
regulation of cell fate specification	GO:0042659	27	0.017
negative regulation of proteolysis	GO:0045861	31	0.017
cellular response to abiotic stimulus	GO:0071214	58	0.017
mitotic dna integrity checkpoint	GO:0044774	75	0.017
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.017
regulation of nucleotide metabolic process	GO:0006140	62	0.017
regulation of intracellular protein transport	GO:0033157	46	0.017
regulation of mrna processing	GO:0050684	71	0.017
response to organic cyclic compound	GO:0014070	89	0.017	Rat
glial cell development	GO:0021782	27	0.017
establishment or maintenance of cell polarity	GO:0007163	167	0.017
positive regulation of cell division	GO:0051781	16	0.017
photoreceptor cell development	GO:0042461	96	0.017
heterocycle catabolic process	GO:0046700	166	0.017
regulation of mitotic cell cycle embryonic	GO:0009794	11	0.016
r3 r4 cell fate commitment	GO:0007464	10	0.016
positive regulation of transferase activity	GO:0051347	26	0.016
positive regulation of response to stimulus	GO:0048584	323	0.016
skin development	GO:0043588	65	0.016
positive regulation of mitotic metaphase anaphase transition	GO:0045842	10	0.016
negative regulation of protein phosphorylation	GO:0001933	17	0.016
germarium derived oocyte differentiation	GO:0030706	29	0.016
regulation of apoptotic process	GO:0042981	130	0.016
regulation of cell development	GO:0060284	215	0.016
negative regulation of cell proliferation	GO:0008285	69	0.016
nuclear transport	GO:0051169	72	0.016
multi organism behavior	GO:0051705	175	0.016
mitotic g2 dna damage checkpoint	GO:0007095	69	0.016
cytoskeleton dependent cytokinesis	GO:0061640	81	0.016
positive regulation of cell death	GO:0010942	69	0.016
dendrite regeneration	GO:0031104	2	0.016

CycE disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.372
organ system cancer	DOID:0050686	0.316
cancer	DOID:162	0.316
intestinal cancer	DOID:10155	0.178
colorectal cancer	DOID:9256	0.178
gastrointestinal system cancer	DOID:3119	0.178
large intestine cancer	DOID:5672	0.178
thoracic cancer	DOID:5093	0.030
breast cancer	DOID:1612	0.021
colon cancer	DOID:219	0.019

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