IMP: Integrative Multi-species Prediction

Drosophila melanogaster

110 known processes

eIF-4E (Dmel_CG4035)

Eukaryotic initiation factor 4E

(Aliases: l(3)S058711,l(3)07238,eif-4e,0919/12,eIF-4EII,CT13384,D-eIF4E,eIF4e,CG4035,eIF-4e,Eif4E,deIF4E,eIF-4E2,eIF-4E1,IF4E,dEif4e,2,Eif4e,l(3)S091912,eIF4E-2,eIF4E1,eIF 4E,CT39426,0260/09,CT39424,deIF-4E,eIF4E-1/2,0587/11,eIF4E,0589/11,l(3)S026009,l(3)S025007,7238,Dmel\CG4035,1004/13,l(3)67Af,CBP,eIF4E-1,eif-4E)

FLYBASE: FBgn0015218
Entrez: 45525
UniProtKB: P48598
UniProtKB: M9PBZ9

Process Predictions
Disease Predictions

eIF-4E biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of growth	GO:0040008	233	0.992
regulation of developmental growth	GO:0048638	174	0.986
axon development	GO:0061564	297	0.985
axonogenesis	GO:0007409	290	0.981
axon guidance	GO:0007411	233	0.955
meiotic cell cycle	GO:0051321	171	0.925
chemotaxis	GO:0006935	249	0.914
organelle assembly	GO:0070925	198	0.910
cellular protein modification process	GO:0006464	438	0.910
neuron projection guidance	GO:0097485	241	0.909
microtubule organizing center organization	GO:0031023	168	0.902
taxis	GO:0042330	304	0.900
protein complex biogenesis	GO:0070271	201	0.886
positive regulation of macromolecule metabolic process	GO:0010604	405	0.858	Worm
cell proliferation	GO:0008283	299	0.856
protein modification process	GO:0036211	438	0.849
small molecule metabolic process	GO:0044281	305	0.847
regulation of cellular protein metabolic process	GO:0032268	243	0.844	Human Worm
macromolecular complex assembly	GO:0065003	256	0.817
cellular protein localization	GO:0034613	160	0.810
female meiotic division	GO:0007143	70	0.790
cell migration	GO:0016477	238	0.789
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.780
synaptic growth at neuromuscular junction	GO:0051124	119	0.748
protein complex assembly	GO:0006461	200	0.745
positive regulation of multicellular organismal process	GO:0051240	143	0.745
cell motility	GO:0048870	251	0.730
positive regulation of phosphate metabolic process	GO:0045937	139	0.689
intracellular signal transduction	GO:0035556	300	0.654
positive regulation of signaling	GO:0023056	243	0.646
death	GO:0016265	284	0.642
cellular catabolic process	GO:0044248	372	0.611
regulation of multicellular organismal development	GO:2000026	414	0.604
positive regulation of developmental growth	GO:0048639	62	0.604
establishment or maintenance of cell polarity	GO:0007163	167	0.603
dendrite development	GO:0016358	204	0.597
cell death	GO:0008219	279	0.591
regulation of intracellular signal transduction	GO:1902531	236	0.578
mitotic spindle organization	GO:0007052	220	0.560
positive regulation of developmental process	GO:0051094	143	0.558
phosphorylation	GO:0016310	294	0.553
regulation of molecular function	GO:0065009	217	0.534
localization of cell	GO:0051674	257	0.514
regulation of anatomical structure morphogenesis	GO:0022603	242	0.510
aromatic compound catabolic process	GO:0019439	166	0.501
mapk cascade	GO:0000165	107	0.491
meiotic nuclear division	GO:0007126	151	0.485
nuclear division	GO:0000280	332	0.482
regulation of phosphate metabolic process	GO:0019220	210	0.467
organelle fission	GO:0048285	340	0.459
mitotic nuclear division	GO:0007067	213	0.457
nucleotide metabolic process	GO:0009117	161	0.452
positive regulation of response to stimulus	GO:0048584	323	0.452
regulation of cell death	GO:0010941	173	0.451
regulation of phosphorylation	GO:0042325	147	0.437
oocyte development	GO:0048599	124	0.419	Worm
lateral inhibition	GO:0046331	206	0.415
muscle structure development	GO:0061061	224	0.413
developmental growth	GO:0048589	280	0.404
multicellular organismal reproductive behavior	GO:0033057	110	0.402
circulatory system development	GO:0072359	82	0.398
cellular macromolecule localization	GO:0070727	220	0.396
organic substance catabolic process	GO:1901575	308	0.386
positive regulation of catalytic activity	GO:0043085	118	0.383
protein localization	GO:0008104	284	0.377
positive regulation of phosphorus metabolic process	GO:0010562	139	0.369
chromosome organization	GO:0051276	360	0.364
apoptotic process	GO:0006915	159	0.359
positive regulation of cellular component organization	GO:0051130	156	0.354
regulation of cellular component biogenesis	GO:0044087	201	0.336
synapse organization	GO:0050808	196	0.334
positive regulation of molecular function	GO:0044093	136	0.331
response to inorganic substance	GO:0010035	44	0.328
spermatogenesis	GO:0007283	200	0.301	Worm
positive regulation of growth	GO:0045927	75	0.301
organic cyclic compound catabolic process	GO:1901361	168	0.301
biological adhesion	GO:0022610	138	0.290
cellular macromolecular complex assembly	GO:0034622	153	0.282
dendrite morphogenesis	GO:0048813	199	0.282
regulation of cell morphogenesis	GO:0022604	163	0.280
meiotic chromosome segregation	GO:0045132	59	0.273
organic acid metabolic process	GO:0006082	103	0.271
positive regulation of multicellular organism growth	GO:0040018	21	0.270
cellular response to dna damage stimulus	GO:0006974	223	0.267
tube development	GO:0035295	244	0.259
organonitrogen compound metabolic process	GO:1901564	318	0.258
regulation of transferase activity	GO:0051338	58	0.256
growth	GO:0040007	359	0.251
regulation of cellular catabolic process	GO:0031329	157	0.243
regulation of purine nucleotide metabolic process	GO:1900542	62	0.241
neurological system process	GO:0050877	358	0.240
regulation of neurogenesis	GO:0050767	158	0.233
dna integrity checkpoint	GO:0031570	81	0.232
regulation of protein metabolic process	GO:0051246	256	0.224	Human Worm
cellular component assembly involved in morphogenesis	GO:0010927	151	0.223
regulation of catalytic activity	GO:0050790	185	0.219
dna damage checkpoint	GO:0000077	78	0.217
protein phosphorylation	GO:0006468	169	0.209
peptidyl amino acid modification	GO:0018193	105	0.209
positive regulation of protein metabolic process	GO:0051247	128	0.206	Worm
body morphogenesis	GO:0010171	2	0.199
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.198
positive regulation of cell communication	GO:0010647	250	0.197
nucleobase containing compound catabolic process	GO:0034655	165	0.197
posttranscriptional regulation of gene expression	GO:0010608	145	0.196	Human Worm
regulation of kinase activity	GO:0043549	53	0.194
male gamete generation	GO:0048232	201	0.190	Worm
actomyosin structure organization	GO:0031032	56	0.183
stem cell development	GO:0048864	79	0.181
actin filament based process	GO:0030029	220	0.178
meiotic cytokinesis	GO:0033206	33	0.178
endocytosis	GO:0006897	310	0.177
cellular protein complex assembly	GO:0043623	71	0.175
regulation of cellular response to stress	GO:0080135	89	0.167
regulation of neuron differentiation	GO:0045664	103	0.166
myofibril assembly	GO:0030239	36	0.165
establishment of localization in cell	GO:0051649	402	0.163
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.163
cell cycle phase transition	GO:0044770	140	0.159	Human
chromosome segregation	GO:0007059	157	0.157
signal transduction by phosphorylation	GO:0023014	107	0.155
purine ribonucleotide metabolic process	GO:0009150	145	0.150
homeostatic process	GO:0042592	199	0.149
organophosphate catabolic process	GO:0046434	112	0.148
regulation of response to stress	GO:0080134	200	0.147
cardiovascular system development	GO:0072358	82	0.146
programmed cell death	GO:0012501	257	0.145
single organism cellular localization	GO:1902580	180	0.145
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.143
ras protein signal transduction	GO:0007265	88	0.143
regulation of phosphorus metabolic process	GO:0051174	210	0.141
protein maturation	GO:0051604	71	0.141
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.138
translation	GO:0006412	69	0.136
head development	GO:0060322	135	0.136
nucleotide catabolic process	GO:0009166	109	0.135
positive regulation of cellular catabolic process	GO:0031331	95	0.130
heterocycle catabolic process	GO:0046700	166	0.127
regulation of protein modification process	GO:0031399	112	0.124
cell adhesion	GO:0007155	136	0.123
regulation of localization	GO:0032879	275	0.121
tissue morphogenesis	GO:0048729	297	0.121
regulation of catabolic process	GO:0009894	170	0.119
multicellular organismal aging	GO:0010259	140	0.116	Worm
oocyte axis specification	GO:0007309	108	0.114
imaginal disc derived appendage development	GO:0048737	399	0.108
regulation of apoptotic process	GO:0042981	130	0.107
centrosome organization	GO:0051297	163	0.106
regulation of translation	GO:0006417	56	0.106	Human Worm
positive regulation of intracellular signal transduction	GO:1902533	116	0.102
centrosome cycle	GO:0007098	137	0.102
regulation of mapk cascade	GO:0043408	92	0.099
positive regulation of signal transduction	GO:0009967	223	0.098
ectodermal digestive tract morphogenesis	GO:0048567	7	0.095
sarcomere organization	GO:0045214	26	0.094
developmental maturation	GO:0021700	172	0.093	Worm
mitotic g2 m transition checkpoint	GO:0044818	70	0.091
reproductive behavior	GO:0019098	122	0.090
larval development	GO:0002164	104	0.089
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.089
response to light stimulus	GO:0009416	124	0.087
nucleoside catabolic process	GO:0009164	112	0.087
nucleoside phosphate catabolic process	GO:1901292	110	0.084
morphogenesis of an epithelium	GO:0002009	276	0.083
regulation of cell differentiation	GO:0045595	302	0.083
striated muscle cell development	GO:0055002	50	0.083
hematopoietic or lymphoid organ development	GO:0048534	57	0.083
purine ribonucleoside catabolic process	GO:0046130	112	0.082
organophosphate metabolic process	GO:0019637	195	0.081
cellular response to chemical stimulus	GO:0070887	199	0.081
regulation of cell cycle	GO:0051726	291	0.079	Human
catabolic process	GO:0009056	409	0.079
gland development	GO:0048732	191	0.078
single organismal cell cell adhesion	GO:0016337	45	0.078
regulation of cell projection organization	GO:0031344	92	0.078
striated muscle myosin thick filament assembly	GO:0071688	3	0.078
mitotic cell cycle phase transition	GO:0044772	138	0.077	Human
ribose phosphate metabolic process	GO:0019693	145	0.076
ribonucleoside metabolic process	GO:0009119	127	0.075
glycosyl compound metabolic process	GO:1901657	127	0.074
regulation of cell migration	GO:0030334	22	0.074
eggshell formation	GO:0030703	105	0.072
regulation of protein kinase activity	GO:0045859	51	0.070
negative regulation of protein metabolic process	GO:0051248	85	0.069
organic substance transport	GO:0071702	257	0.069
genitalia development	GO:0048806	26	0.068
stem cell maintenance	GO:0019827	67	0.068
mitotic g2 dna damage checkpoint	GO:0007095	69	0.067
purine nucleoside metabolic process	GO:0042278	127	0.064
apoptotic signaling pathway	GO:0097190	27	0.064
g2 dna damage checkpoint	GO:0031572	69	0.064
dephosphorylation	GO:0016311	51	0.064
carbohydrate derivative metabolic process	GO:1901135	217	0.063
cell maturation	GO:0048469	144	0.063	Worm
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.062
mitotic dna damage checkpoint	GO:0044773	74	0.061
neuron death	GO:0070997	27	0.061
positive regulation of hydrolase activity	GO:0051345	78	0.061
regulation of cell shape	GO:0008360	113	0.061
negative regulation of apoptotic process	GO:0043066	63	0.060
central nervous system development	GO:0007417	201	0.059
purine nucleotide metabolic process	GO:0006163	146	0.059
negative regulation of cellular metabolic process	GO:0031324	382	0.059
glycosyl compound catabolic process	GO:1901658	112	0.058
positive regulation of phosphorylation	GO:0042327	87	0.057
negative regulation of response to stimulus	GO:0048585	258	0.056
multi organism behavior	GO:0051705	175	0.056
response to radiation	GO:0009314	155	0.056
purine ribonucleoside metabolic process	GO:0046128	127	0.055
ribonucleotide catabolic process	GO:0009261	109	0.054
regulation of mitotic cell cycle	GO:0007346	190	0.054	Human
guanosine containing compound metabolic process	GO:1901068	74	0.053
development of primary sexual characteristics	GO:0045137	50	0.050
hematopoietic stem cell differentiation	GO:0060218	1	0.049
vesicle mediated transport	GO:0016192	381	0.049
ribonucleoside catabolic process	GO:0042454	112	0.049
establishment of nucleus localization	GO:0040023	26	0.048
reproductive system development	GO:0061458	74	0.048
regulation of cytoskeleton organization	GO:0051493	89	0.048
peptidyl tyrosine phosphorylation	GO:0018108	24	0.048
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.048
developmental cell growth	GO:0048588	52	0.047
regulation of neuron projection development	GO:0010975	69	0.045
positive regulation of catabolic process	GO:0009896	105	0.045
regulation of proteasomal protein catabolic process	GO:0061136	39	0.045
protein catabolic process	GO:0030163	101	0.045
regulation of neuron death	GO:1901214	26	0.044
regulation of trichome morphogenesis	GO:2000039	3	0.044
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.044
purine ribonucleotide catabolic process	GO:0009154	109	0.043
regulation of cell cycle process	GO:0010564	181	0.043
proteasomal protein catabolic process	GO:0010498	59	0.043
skin development	GO:0043588	65	0.042
gonad development	GO:0008406	50	0.042
cell cycle checkpoint	GO:0000075	95	0.041
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.041
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.041
negative regulation of molecular function	GO:0044092	51	0.040
actin cytoskeleton organization	GO:0030036	206	0.040
positive regulation of kinase activity	GO:0033674	25	0.040
regulation of organelle organization	GO:0033043	196	0.040
oocyte morphogenesis	GO:0048601	3	0.040
spindle assembly	GO:0051225	80	0.040
regulation of locomotion	GO:0040012	42	0.038
striated muscle cell differentiation	GO:0051146	90	0.038
gliogenesis	GO:0042063	80	0.037
positive regulation of protein phosphorylation	GO:0001934	34	0.037
anterior posterior pattern specification	GO:0009952	136	0.037
ribonucleotide metabolic process	GO:0009259	145	0.037
oviposition	GO:0018991	19	0.037
regulation of protein phosphorylation	GO:0001932	64	0.036
nucleoside triphosphate metabolic process	GO:0009141	120	0.036
carboxylic acid metabolic process	GO:0019752	92	0.036
multi multicellular organism process	GO:0044706	123	0.035
single organism nuclear import	GO:1902593	51	0.035
sex differentiation	GO:0007548	81	0.035
purine nucleotide catabolic process	GO:0006195	109	0.034
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.034	Worm
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.034
dna replication	GO:0006260	48	0.033
negative regulation of nervous system development	GO:0051961	92	0.033
nucleoside triphosphate catabolic process	GO:0009143	108	0.033
embryo development ending in birth or egg hatching	GO:0009792	152	0.033	Worm
single organism catabolic process	GO:0044712	228	0.032
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.032
regulation of programmed cell death	GO:0043067	152	0.032
developmental programmed cell death	GO:0010623	138	0.031
dendrite regeneration	GO:0031104	2	0.031
cellular amino acid metabolic process	GO:0006520	61	0.031
cellular nitrogen compound catabolic process	GO:0044270	165	0.030
negative regulation of cellular protein metabolic process	GO:0032269	85	0.030
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.030
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.030
purine nucleoside catabolic process	GO:0006152	112	0.030
muscle attachment	GO:0016203	36	0.030
negative regulation of developmental growth	GO:0048640	64	0.030
oocyte construction	GO:0007308	112	0.030
regulation of centriole centriole cohesion	GO:0030997	1	0.029
regulation of multicellular organism growth	GO:0040014	40	0.029
protein targeting	GO:0006605	64	0.029
negative regulation of multicellular organismal process	GO:0051241	142	0.029
negative regulation of cell cycle	GO:0045786	116	0.028
epithelial cell fate determination open tracheal system	GO:0007425	2	0.028
tube morphogenesis	GO:0035239	191	0.028
multicellular organism growth	GO:0035264	46	0.027
positive regulation of cell maturation	GO:1903431	2	0.027
response to red or far red light	GO:0009639	2	0.027
small gtpase mediated signal transduction	GO:0007264	88	0.026
ameboidal type cell migration	GO:0001667	151	0.026
chromatin modification	GO:0016568	147	0.026
activation of anaphase promoting complex activity	GO:0051488	1	0.026
cell recognition	GO:0008037	102	0.025
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.025
negative regulation of translation	GO:0017148	28	0.025
imaginal disc derived wing morphogenesis	GO:0007476	337	0.025
regulation of cell cycle phase transition	GO:1901987	130	0.025
negative regulation of signaling	GO:0023057	219	0.024
female germ line cyst formation	GO:0048135	42	0.024
negative regulation of cell communication	GO:0010648	223	0.024
regulation of cell development	GO:0060284	215	0.024
regulation of nucleotide metabolic process	GO:0006140	62	0.024
respiratory system development	GO:0060541	213	0.024
synaptic transmission	GO:0007268	288	0.023
oocyte fate commitment	GO:0048600	2	0.023
axis specification	GO:0009798	167	0.023
detection of external stimulus	GO:0009581	66	0.023
camera type eye development	GO:0043010	4	0.023
ubiquitin dependent protein catabolic process	GO:0006511	78	0.023
regulation of cell substrate adhesion	GO:0010810	2	0.023
regulation of synapse assembly	GO:0051963	94	0.022
regulation of peptidyl tyrosine phosphorylation	GO:0050730	10	0.022
meiotic nuclear envelope disassembly	GO:0051078	2	0.022
phagocytosis	GO:0006909	215	0.022
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.022
cellularization	GO:0007349	90	0.022
cellular protein catabolic process	GO:0044257	83	0.022
modification dependent macromolecule catabolic process	GO:0043632	79	0.022
meiotic cell cycle process	GO:1903046	132	0.022
mitotic spindle elongation	GO:0000022	81	0.022
establishment of cell polarity	GO:0030010	40	0.021
photoreceptor cell differentiation	GO:0046530	170	0.021
aging	GO:0007568	143	0.021	Worm
maintenance of location	GO:0051235	73	0.021	Worm
peptidyl tyrosine modification	GO:0018212	24	0.021
response to biotic stimulus	GO:0009607	294	0.021
regulation of calcium ion transmembrane transport	GO:1903169	2	0.021
meiotic spindle checkpoint	GO:0044779	1	0.021
purine containing compound catabolic process	GO:0072523	112	0.020
regulation of synapse structure and activity	GO:0050803	128	0.020
embryonic development via the syncytial blastoderm	GO:0001700	148	0.020
regulation of intracellular transport	GO:0032386	64	0.020
negative regulation of terminal cell fate specification open tracheal system	GO:0035155	2	0.020
muscle organ development	GO:0007517	127	0.020
protein targeting to nucleus	GO:0044744	51	0.019
negative regulation of nucleotide metabolic process	GO:0045980	4	0.019
negative regulation of mitotic cell cycle	GO:0045930	109	0.019
germarium derived female germ line cyst formation	GO:0030727	42	0.019
regulation of cell proliferation	GO:0042127	163	0.019
nucleoside phosphate metabolic process	GO:0006753	162	0.018
immune system process	GO:0002376	347	0.018
centrosome duplication	GO:0051298	121	0.018
positive regulation of protein modification process	GO:0031401	58	0.018
negative regulation of phosphatase activity	GO:0010923	3	0.018
intracellular transport	GO:0046907	228	0.018
single organism behavior	GO:0044708	391	0.018
positive regulation of transferase activity	GO:0051347	26	0.018
regulation of cellular ketone metabolic process	GO:0010565	3	0.017
positive regulation of biosynthetic process	GO:0009891	316	0.017	Worm
post embryonic appendage morphogenesis	GO:0035120	385	0.017
positive regulation of synaptic transmission cholinergic	GO:0032224	2	0.016
protein localization to organelle	GO:0033365	82	0.016
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	2	0.016
cell aging	GO:0007569	2	0.016
specification of segmental identity antennal segment	GO:0007383	2	0.016
dna metabolic process	GO:0006259	227	0.016
immune system development	GO:0002520	57	0.016
chorion containing eggshell formation	GO:0007304	105	0.016
positive regulation of intracellular protein transport	GO:0090316	30	0.016
spindle localization	GO:0051653	22	0.016
membrane organization	GO:0061024	112	0.015
regulation of nucleocytoplasmic transport	GO:0046822	35	0.015
myosin filament organization	GO:0031033	5	0.015
negative regulation of signal transduction	GO:0009968	206	0.015
regulation of cell size	GO:0008361	63	0.015
negative regulation of filopodium assembly	GO:0051490	3	0.015
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.015
regulation of immune system process	GO:0002682	176	0.015
histone h3 k9 modification	GO:0061647	12	0.015
negative regulation of cellular catabolic process	GO:0031330	34	0.015
positive regulation of cellular amine metabolic process	GO:0033240	0	0.015
regulation of behavior	GO:0050795	75	0.015
negative regulation of dna templated transcription initiation	GO:2000143	1	0.015
brain development	GO:0007420	120	0.014
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.014
negative regulation of cell differentiation	GO:0045596	143	0.014
establishment of organelle localization	GO:0051656	122	0.014
nucleoside metabolic process	GO:0009116	127	0.014
regulation of cellular localization	GO:0060341	136	0.014
epidermis development	GO:0008544	65	0.014
dorsal vessel heart proper cell fate commitment	GO:0035053	2	0.014
embryonic morphogenesis	GO:0048598	206	0.014
anterior posterior axis specification	GO:0009948	109	0.014
cellular response to nutrient	GO:0031670	1	0.014
neuronal action potential	GO:0019228	10	0.014
positive regulation of apoptotic process	GO:0043065	47	0.014
dna integration	GO:0015074	1	0.014
regulation of protein catabolic process	GO:0042176	55	0.014
neuromuscular junction development	GO:0007528	149	0.013
negative regulation of cell death	GO:0060548	81	0.013
negative regulation of growth	GO:0045926	84	0.013
lipid localization	GO:0010876	54	0.013	Worm
dna catabolic process endonucleolytic	GO:0000737	6	0.013
positive regulation of cell substrate adhesion	GO:0010811	1	0.013
open tracheal system development	GO:0007424	204	0.013
spindle assembly involved in mitosis	GO:0090307	50	0.013
lipid storage	GO:0019915	38	0.013	Worm
regulation of mitotic spindle checkpoint	GO:1903504	1	0.013
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.013
positive regulation of transcription involved in g2 m transition of mitotic cell cycle	GO:0090282	1	0.013
protein processing	GO:0016485	68	0.012
regulation of cell division	GO:0051302	72	0.012
regulation of histone methylation	GO:0031060	10	0.012
muscle cell development	GO:0055001	50	0.012
dna templated transcriptional start site selection	GO:0001173	1	0.012
cell division	GO:0051301	248	0.012
anterior posterior axis specification follicular epithelium	GO:0030714	2	0.012
meiotic dna repair synthesis	GO:0000711	3	0.012
regulation of sequence specific dna binding transcription factor activity	GO:0051090	12	0.012
multicellular organismal homeostasis	GO:0048871	41	0.012
anterior head segmentation	GO:0035288	3	0.012
epidermal cell differentiation	GO:0009913	51	0.012
hormone metabolic process	GO:0042445	33	0.012
telencephalon development	GO:0021537	2	0.012
response to oxygen containing compound	GO:1901700	200	0.011
negative regulation of mrna 3 end processing	GO:0031441	3	0.011
negative regulation of developmental process	GO:0051093	201	0.011
negative regulation of gene expression	GO:0010629	387	0.011
purine containing compound metabolic process	GO:0072521	155	0.011
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0017055	1	0.011
positive regulation of store operated calcium channel activity	GO:1901341	1	0.011
regulation of ras protein signal transduction	GO:0046578	93	0.011
axonal fasciculation	GO:0007413	12	0.011
notum development	GO:0007477	8	0.011
embryonic axis specification	GO:0000578	107	0.011
organonitrogen compound catabolic process	GO:1901565	128	0.011
determination of adult lifespan	GO:0008340	137	0.011	Worm
nucleobase containing small molecule metabolic process	GO:0055086	174	0.011
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.011
eggshell chorion assembly	GO:0007306	66	0.011
p granule organization	GO:0030719	4	0.011
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.011
mitotic sister chromatid segregation	GO:0000070	87	0.011
asymmetric neuroblast division resulting in ganglion mother cell formation	GO:0055060	2	0.011
microtubule cytoskeleton organization involved in establishment of planar polarity	GO:0090176	3	0.011
reproductive structure development	GO:0048608	74	0.011
positive regulation of posttranscriptional gene silencing	GO:0060148	5	0.011
multi organism reproductive behavior	GO:0044705	121	0.010
positive regulation of transcription dna templated	GO:0045893	266	0.010
regulation of substrate adhesion dependent cell spreading	GO:1900024	1	0.010
regulation of sphingolipid biosynthetic process	GO:0090153	2	0.010
release of cytoplasmic sequestered nf kappab	GO:0008588	1	0.010
morphogenesis of a branching structure	GO:0001763	45	0.010
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.010
positive regulation of proteolysis	GO:0045862	52	0.010

eIF-4E disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of cellular proliferation	DOID:14566	0.115
connective tissue disease	DOID:65	0.067
musculoskeletal system disease	DOID:17	0.067
dysostosis	DOID:1934	0.067
bone disease	DOID:0080001	0.067
bone development disease	DOID:0080006	0.067
disease of anatomical entity	DOID:7	0.067
brachydactyly	DOID:0050581	0.067
organ system cancer	DOID:0050686	0.052
cancer	DOID:162	0.052
ovarian cancer	DOID:2394	0.034
female reproductive organ cancer	DOID:120	0.034
reproductive organ cancer	DOID:193	0.034
aortic aneurysm	DOID:3627	0.030
aortic disease	DOID:520	0.030
artery disease	DOID:0050828	0.030
vascular disease	DOID:178	0.030
cardiovascular system disease	DOID:1287	0.030
pancreatic cancer	DOID:1793	0.016
pancreatic carcinoma	DOID:4905	0.016
endocrine gland cancer	DOID:170	0.016
pervasive developmental disorder	DOID:0060040	0.015	Human
disease of mental health	DOID:150	0.015	Human
developmental disorder of mental health	DOID:0060037	0.015	Human
hepatobiliary disease	DOID:3118	0.013
alagille syndrome	DOID:9245	0.013
liver disease	DOID:409	0.013
gastrointestinal system disease	DOID:77	0.013

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