IMP: Integrative Multi-species Prediction

Drosophila melanogaster

42 known processes

Megalin (Dmel_CG42611)

CG42611 gene product from transcript CG42611-RA

(Aliases: Dmel\CG42611,CG42611,CG34352,CG12654,Dmel_CG12654,CG12139,Dmel_CG34352,LDLR,CG15316,CT7830,Dmel_CG34339,SOSIE,Dmel_CG12139,anon-WO0140519.108,CG34339)

Entrez: 8674055
FLYBASE: FBgn0261260
UniProtKB: A8JTM7

Process Predictions
Disease Predictions

Megalin biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cuticle development	GO:0042335	86	0.468
chitin based cuticle development	GO:0040003	49	0.356
respiratory system development	GO:0060541	213	0.318
taxis	GO:0042330	304	0.276
open tracheal system development	GO:0007424	204	0.226
cellular protein modification process	GO:0006464	438	0.160
wing disc morphogenesis	GO:0007472	344	0.159
chemotaxis	GO:0006935	249	0.139
positive regulation of macromolecule metabolic process	GO:0010604	405	0.138
transcription from rna polymerase ii promoter	GO:0006366	368	0.128
negative regulation of signaling	GO:0023057	219	0.122
epithelium migration	GO:0090132	148	0.120
post embryonic appendage morphogenesis	GO:0035120	385	0.113
regulation of multicellular organismal development	GO:2000026	414	0.111
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.109
negative regulation of response to stimulus	GO:0048585	258	0.107
regulation of protein metabolic process	GO:0051246	256	0.099
negative regulation of cellular metabolic process	GO:0031324	382	0.094
imaginal disc derived wing morphogenesis	GO:0007476	337	0.086
endomembrane system organization	GO:0010256	119	0.086
biological adhesion	GO:0022610	138	0.084
negative regulation of cell communication	GO:0010648	223	0.080
tissue migration	GO:0090130	155	0.078
appendage development	GO:0048736	401	0.077
appendage morphogenesis	GO:0035107	397	0.076
protein modification process	GO:0036211	438	0.076
negative regulation of signal transduction	GO:0009968	206	0.075
branching involved in open tracheal system development	GO:0060446	45	0.075
adult chitin containing cuticle pigmentation	GO:0048085	16	0.074
mapk cascade	GO:0000165	107	0.073
imaginal disc derived appendage development	GO:0048737	399	0.070
positive regulation of cell migration	GO:0030335	2	0.069
regulation of molecular function	GO:0065009	217	0.069
regulation of hydrolase activity	GO:0051336	97	0.068
positive regulation of molecular function	GO:0044093	136	0.068
regulation of cell differentiation	GO:0045595	302	0.065
regulation of developmental pigmentation	GO:0048070	24	0.065
negative regulation of growth	GO:0045926	84	0.065
regulation of cell cycle	GO:0051726	291	0.063
organonitrogen compound metabolic process	GO:1901564	318	0.063
regulation of response to stress	GO:0080134	200	0.061
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.060
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.060
regulation of cellular amine metabolic process	GO:0033238	3	0.058
carbohydrate derivative metabolic process	GO:1901135	217	0.057
histoblast morphogenesis	GO:0007488	9	0.057
regulation of multi organism process	GO:0043900	131	0.056
regulation of cellular protein metabolic process	GO:0032268	243	0.056
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.055
o glycan processing	GO:0016266	3	0.054
regulation of response to external stimulus	GO:0032101	115	0.053
regulation of cuticle pigmentation	GO:0048079	16	0.053
response to organic substance	GO:0010033	284	0.053
cell adhesion	GO:0007155	136	0.052
immune response regulating signaling pathway	GO:0002764	2	0.052
negative regulation of biosynthetic process	GO:0009890	277	0.052
localization of cell	GO:0051674	257	0.050
regulation of catalytic activity	GO:0050790	185	0.050
small molecule metabolic process	GO:0044281	305	0.049
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.049
positive regulation of cell motility	GO:2000147	3	0.049
neuron projection guidance	GO:0097485	241	0.048
muscle organ development	GO:0007517	127	0.048
catabolic process	GO:0009056	409	0.047
regulation of localization	GO:0032879	275	0.047
organic substance transport	GO:0071702	257	0.046
axonogenesis	GO:0007409	290	0.045
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.045
regulation of phosphate metabolic process	GO:0019220	210	0.044
oxoacid metabolic process	GO:0043436	103	0.044
cuticle pigmentation	GO:0048067	22	0.042
amine metabolic process	GO:0009308	12	0.042
chromatin modification	GO:0016568	147	0.042
positive regulation of multi organism process	GO:0043902	40	0.042
positive regulation of protein metabolic process	GO:0051247	128	0.042
cell migration	GO:0016477	238	0.041
cell motility	GO:0048870	251	0.041
positive regulation of catalytic activity	GO:0043085	118	0.040
tube development	GO:0035295	244	0.040
negative regulation of gene expression	GO:0010629	387	0.040
positive regulation of peptidase activity	GO:0010952	29	0.039
response to abiotic stimulus	GO:0009628	341	0.039
regulation of proteolysis	GO:0030162	87	0.039
regulation of cellular component movement	GO:0051270	42	0.039
embryonic development via the syncytial blastoderm	GO:0001700	148	0.038
macromolecule catabolic process	GO:0009057	161	0.038
proteolysis	GO:0006508	192	0.037
regulation of cellular response to stress	GO:0080135	89	0.037
regulation of rna splicing	GO:0043484	69	0.037
phagocytosis	GO:0006909	215	0.037
regulation of cellular ketone metabolic process	GO:0010565	3	0.037
intracellular signal transduction	GO:0035556	300	0.036
positive regulation of cellular protein metabolic process	GO:0032270	118	0.036
epithelial cell migration	GO:0010631	148	0.035
negative regulation of catalytic activity	GO:0043086	42	0.035
single organismal cell cell adhesion	GO:0016337	45	0.034
positive regulation of phosphate metabolic process	GO:0045937	139	0.034
dendrite morphogenesis	GO:0048813	199	0.034
regulation of response to biotic stimulus	GO:0002831	63	0.034
regulation of endopeptidase activity	GO:0052548	36	0.034
regulation of phosphorus metabolic process	GO:0051174	210	0.034
ameboidal type cell migration	GO:0001667	151	0.033
chitin based cuticle sclerotization	GO:0007593	19	0.033
organic substance catabolic process	GO:1901575	308	0.033
cell division	GO:0051301	248	0.033
embryonic morphogenesis	GO:0048598	206	0.032
instar larval development	GO:0002168	55	0.032
inter male aggressive behavior	GO:0002121	60	0.032
cellular macromolecule localization	GO:0070727	220	0.031
cellular ketone metabolic process	GO:0042180	24	0.031
regulation of sterol transport	GO:0032371	1	0.031
positive regulation of response to stimulus	GO:0048584	323	0.031
actin cytoskeleton organization	GO:0030036	206	0.031
g protein coupled receptor signaling pathway	GO:0007186	136	0.031
positive regulation of hydrolase activity	GO:0051345	78	0.031
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.030
neurological system process	GO:0050877	358	0.030
regulation of peptidase activity	GO:0052547	39	0.030
ribonucleoside catabolic process	GO:0042454	112	0.029
axis specification	GO:0009798	167	0.029
small gtpase mediated signal transduction	GO:0007264	88	0.029
response to light stimulus	GO:0009416	124	0.029
axon development	GO:0061564	297	0.028
intracellular transport	GO:0046907	228	0.028
growth	GO:0040007	359	0.028
single organism biosynthetic process	GO:0044711	206	0.028
negative regulation of erbb signaling pathway	GO:1901185	29	0.028
regionalization	GO:0003002	416	0.028
dorsal closure	GO:0007391	79	0.028
head development	GO:0060322	135	0.027
glycoprotein biosynthetic process	GO:0009101	41	0.027
aggressive behavior	GO:0002118	63	0.027
regulation of cellular component biogenesis	GO:0044087	201	0.027
single organism cell adhesion	GO:0098602	47	0.027
morphogenesis of an epithelium	GO:0002009	276	0.027
regulation of cell motility	GO:2000145	23	0.027
embryo development ending in birth or egg hatching	GO:0009792	152	0.026
connective tissue development	GO:0061448	3	0.026
dorsal ventral axis specification	GO:0009950	66	0.026
endocytosis	GO:0006897	310	0.026
cell cell junction organization	GO:0045216	55	0.025
carboxylic acid metabolic process	GO:0019752	92	0.025
response to toxic substance	GO:0009636	22	0.025
cell junction organization	GO:0034330	57	0.025
vesicle mediated transport	GO:0016192	381	0.025
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.025
negative regulation of intracellular signal transduction	GO:1902532	57	0.025
cellular macromolecule catabolic process	GO:0044265	136	0.025
regulation of mapk cascade	GO:0043408	92	0.025
regulation of cell migration	GO:0030334	22	0.025
regulation of mitotic cell cycle	GO:0007346	190	0.025
protein catabolic process	GO:0030163	101	0.025
cellular component assembly involved in morphogenesis	GO:0010927	151	0.025
positive regulation of signal transduction	GO:0009967	223	0.024
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.024
glycoprotein metabolic process	GO:0009100	41	0.024
response to wounding	GO:0009611	94	0.024
extracellular matrix constituent secretion	GO:0070278	4	0.024
regulation of cellular amino acid metabolic process	GO:0006521	0	0.024
wound healing	GO:0042060	75	0.024
dendrite development	GO:0016358	204	0.024
tube morphogenesis	GO:0035239	191	0.024
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.023
single organism intracellular transport	GO:1902582	207	0.023
response to alcohol	GO:0097305	95	0.023
developmental growth	GO:0048589	280	0.023
regulation of tube architecture open tracheal system	GO:0035152	68	0.023
regulation of anatomical structure morphogenesis	GO:0022603	242	0.023
cellular amino acid metabolic process	GO:0006520	61	0.023
cuticle pattern formation	GO:0035017	27	0.023
regulation of phosphorylation	GO:0042325	147	0.023
compound eye development	GO:0048749	307	0.022
columnar cuboidal epithelial cell development	GO:0002066	249	0.022
single organism cellular localization	GO:1902580	180	0.022
morphogenesis of a branching structure	GO:0001763	45	0.022
chromosome organization	GO:0051276	360	0.021
establishment of protein localization	GO:0045184	163	0.021
positive regulation of proteolysis	GO:0045862	52	0.021
actin filament organization	GO:0007015	126	0.021
rna processing	GO:0006396	147	0.021
death	GO:0016265	284	0.021
regulation of g protein coupled receptor protein signaling pathway	GO:0008277	23	0.021
spindle organization	GO:0007051	253	0.021
protein phosphorylation	GO:0006468	169	0.021
positive regulation of response to external stimulus	GO:0032103	44	0.021
detection of visible light	GO:0009584	38	0.021
glycosyl compound catabolic process	GO:1901658	112	0.021
regulation of intracellular signal transduction	GO:1902531	236	0.020
chromosome segregation	GO:0007059	157	0.020
regulation of protein localization	GO:0032880	76	0.020
memory	GO:0007613	94	0.020
digestive system development	GO:0055123	149	0.020
immune response activating signal transduction	GO:0002757	2	0.020
modification dependent macromolecule catabolic process	GO:0043632	79	0.020
molting cycle chitin based cuticle	GO:0007591	56	0.019
gene silencing	GO:0016458	138	0.019
response to biotic stimulus	GO:0009607	294	0.019
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	26	0.019
regulation of neurogenesis	GO:0050767	158	0.019
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.019
learning or memory	GO:0007611	141	0.019
regulation of locomotion	GO:0040012	42	0.019
negative regulation of protein metabolic process	GO:0051248	85	0.019
negative regulation of endopeptidase activity	GO:0010951	11	0.019
compound eye photoreceptor development	GO:0042051	78	0.019
chromatin organization	GO:0006325	207	0.019
intracellular protein transport	GO:0006886	104	0.019
cellular amine metabolic process	GO:0044106	12	0.019
deactivation of rhodopsin mediated signaling	GO:0016059	17	0.019
actin filament bundle assembly	GO:0051017	26	0.019
response to ethanol	GO:0045471	59	0.019
sensory perception of smell	GO:0007608	80	0.019
regulation of anatomical structure size	GO:0090066	163	0.019
reproductive system development	GO:0061458	74	0.019
protein transport	GO:0015031	155	0.019
response to lipopolysaccharide	GO:0032496	4	0.019
leg disc development	GO:0035218	92	0.018
regulation of cytoskeleton organization	GO:0051493	89	0.018
telencephalon development	GO:0021537	2	0.018
cytoplasmic transport	GO:0016482	130	0.018
positive regulation of cellular biosynthetic process	GO:0031328	316	0.018
negative regulation of cellular biosynthetic process	GO:0031327	277	0.018
mitotic spindle organization	GO:0007052	220	0.018
positive regulation of gtp catabolic process	GO:0033126	43	0.018
detection of stimulus involved in sensory perception	GO:0050906	92	0.018
negative regulation of molecular function	GO:0044092	51	0.018
molting cycle	GO:0042303	56	0.018
rna splicing	GO:0008380	83	0.018
regulation of protein modification process	GO:0031399	112	0.018
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.018
central nervous system development	GO:0007417	201	0.018
regulation of cell adhesion	GO:0030155	27	0.017
cell cell adhesion	GO:0098609	26	0.017
morphogenesis of embryonic epithelium	GO:0016331	94	0.017
cellular response to carbohydrate stimulus	GO:0071322	4	0.017
apoptotic process	GO:0006915	159	0.017
regulation of transferase activity	GO:0051338	58	0.017
regulation of cell proliferation	GO:0042127	163	0.017
single organism behavior	GO:0044708	391	0.017
cellular response to molecule of bacterial origin	GO:0071219	3	0.017
regulation of tube length open tracheal system	GO:0035159	24	0.017
carbohydrate derivative biosynthetic process	GO:1901137	85	0.017
mitotic nuclear division	GO:0007067	213	0.017
cytoskeleton dependent cytokinesis	GO:0061640	81	0.017
gtp metabolic process	GO:0046039	72	0.017
adult behavior	GO:0030534	137	0.017
nucleoside catabolic process	GO:0009164	112	0.017
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.016
golgi vesicle transport	GO:0048193	27	0.016
nucleoside phosphate catabolic process	GO:1901292	110	0.016
sensory perception	GO:0007600	196	0.016
tissue morphogenesis	GO:0048729	297	0.016
epithelial cell differentiation	GO:0030855	322	0.016
regulation of nucleoside metabolic process	GO:0009118	50	0.016
spermatid differentiation	GO:0048515	114	0.016
regulation of intracellular transport	GO:0032386	64	0.016
cell fate determination	GO:0001709	91	0.016
smoothened signaling pathway	GO:0007224	49	0.016
regulation of cell shape	GO:0008360	113	0.016
cell cell junction assembly	GO:0007043	38	0.016
secretion	GO:0046903	109	0.016
response to endogenous stimulus	GO:0009719	119	0.016
peptidyl amino acid modification	GO:0018193	105	0.016
regulation of smoothened signaling pathway	GO:0008589	28	0.016
positive regulation of intracellular signal transduction	GO:1902533	116	0.015
nucleobase containing compound catabolic process	GO:0034655	165	0.015
protein modification by small protein conjugation	GO:0032446	79	0.015
ubiquitin dependent protein catabolic process	GO:0006511	78	0.015
negative regulation of phosphorus metabolic process	GO:0010563	45	0.015
regulation of protein kinase activity	GO:0045859	51	0.015
membrane depolarization	GO:0051899	4	0.015
positive regulation of cell proliferation	GO:0008284	47	0.015
regulation of notch signaling pathway	GO:0008593	100	0.015
regulation of behavior	GO:0050795	75	0.015
negative regulation of developmental growth	GO:0048640	64	0.015
adult locomotory behavior	GO:0008344	76	0.015
spermatid development	GO:0007286	98	0.015
regulation of reproductive process	GO:2000241	54	0.015
ion transport	GO:0006811	145	0.015
negative regulation of organ growth	GO:0046621	15	0.015
dorsal ventral pattern formation	GO:0009953	133	0.015
regulation of response to wounding	GO:1903034	19	0.015
cellular response to organic substance	GO:0071310	132	0.015
epithelial tube morphogenesis	GO:0060562	88	0.015
cellular protein catabolic process	GO:0044257	83	0.015
organic acid metabolic process	GO:0006082	103	0.015
striated muscle tissue development	GO:0014706	27	0.015
posttranscriptional gene silencing by rna	GO:0035194	45	0.015
branch fusion open tracheal system	GO:0035147	17	0.015
regulation of mrna processing	GO:0050684	71	0.015
sensory organ morphogenesis	GO:0090596	260	0.015
regulation of growth	GO:0040008	233	0.014
male gamete generation	GO:0048232	201	0.014
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.014
golgi organization	GO:0007030	66	0.014
metal ion transport	GO:0030001	74	0.014
protein maturation	GO:0051604	71	0.014
phosphorylation	GO:0016310	294	0.014
regulation of cytoplasmic transport	GO:1903649	47	0.014
positive regulation of gene expression	GO:0010628	290	0.014
cellular response to light stimulus	GO:0071482	37	0.014
negative regulation of cellular protein metabolic process	GO:0032269	85	0.014
regulation of organelle organization	GO:0033043	196	0.014
regulation of transport	GO:0051049	181	0.014
larval development	GO:0002164	104	0.014
regulation of apoptotic process	GO:0042981	130	0.014
eye pigmentation	GO:0048069	43	0.014
transmembrane transport	GO:0055085	139	0.014
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.014
adherens junction organization	GO:0034332	27	0.014
negative regulation of transcription dna templated	GO:0045892	237	0.014
protein ubiquitination	GO:0016567	70	0.014
single organism catabolic process	GO:0044712	228	0.014
sperm individualization	GO:0007291	48	0.014
cellular response to biotic stimulus	GO:0071216	4	0.014
cell growth	GO:0016049	108	0.014
pattern recognition receptor signaling pathway	GO:0002221	2	0.014
heterocycle catabolic process	GO:0046700	166	0.014
negative regulation of programmed cell death	GO:0043069	72	0.014
forebrain development	GO:0030900	2	0.014
nuclear division	GO:0000280	332	0.014
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.014
positive regulation of signaling	GO:0023056	243	0.014
nucleoside triphosphate catabolic process	GO:0009143	108	0.014
organonitrogen compound biosynthetic process	GO:1901566	117	0.014
regulation of epithelial cell proliferation	GO:0050678	4	0.013
purine nucleoside catabolic process	GO:0006152	112	0.013
regulation of immune system process	GO:0002682	176	0.013
regulation of programmed cell death	GO:0043067	152	0.013
circulatory system development	GO:0072359	82	0.013
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.013
sensory perception of chemical stimulus	GO:0007606	116	0.013
positive regulation of phosphorylation	GO:0042327	87	0.013
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.013
response to radiation	GO:0009314	155	0.013
epithelial cell development	GO:0002064	274	0.013
cell proliferation	GO:0008283	299	0.013
regulation of cell development	GO:0060284	215	0.013
protein localization	GO:0008104	284	0.013
programmed cell death	GO:0012501	257	0.013
ovarian follicle cell development	GO:0030707	248	0.013
positive regulation of protein modification process	GO:0031401	58	0.013
regulation of chitin based cuticle tanning	GO:0007564	14	0.013
organelle assembly	GO:0070925	198	0.013
establishment of localization in cell	GO:0051649	402	0.013
organic cyclic compound catabolic process	GO:1901361	168	0.013
peptidyl threonine modification	GO:0018210	3	0.013
lateral inhibition	GO:0046331	206	0.013
cell junction assembly	GO:0034329	42	0.013
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.013
actin filament based process	GO:0030029	220	0.013
regulation of adult chitin containing cuticle pigmentation	GO:0048082	13	0.013
cellular nitrogen compound catabolic process	GO:0044270	165	0.013
regulation of catabolic process	GO:0009894	170	0.013
morphogenesis of a branching epithelium	GO:0061138	45	0.013
signal transduction by phosphorylation	GO:0023014	107	0.012
chorion containing eggshell formation	GO:0007304	105	0.012
muscle structure development	GO:0061061	224	0.012
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.012
regulation of cell fate specification	GO:0042659	27	0.012
positive regulation of phosphorus metabolic process	GO:0010562	139	0.012
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.012
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.012
regulation of actin filament based process	GO:0032970	42	0.012
pigmentation	GO:0043473	75	0.012
genital disc development	GO:0035215	44	0.012
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.012
nucleotide metabolic process	GO:0009117	161	0.012
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.012
purine nucleotide catabolic process	GO:0006195	109	0.012
detection of light stimulus	GO:0009583	58	0.012
convergent extension	GO:0060026	2	0.012
nucleus organization	GO:0006997	45	0.012
membrane organization	GO:0061024	112	0.012
single organism carbohydrate metabolic process	GO:0044723	72	0.012
branching morphogenesis of an epithelial tube	GO:0048754	45	0.012
aminoglycan metabolic process	GO:0006022	18	0.012
regulation of protein transport	GO:0051223	57	0.012
cellular response to lipopolysaccharide	GO:0071222	3	0.012
protein processing	GO:0016485	68	0.012
divalent inorganic cation transport	GO:0072511	30	0.012
developmental maturation	GO:0021700	172	0.012
regulation of cholesterol transport	GO:0032374	1	0.012
developmental cell growth	GO:0048588	52	0.012
spinal cord development	GO:0021510	1	0.012
positive regulation of cell communication	GO:0010647	250	0.012
single organism nuclear import	GO:1902593	51	0.012
anterior posterior axis specification embryo	GO:0008595	103	0.012
peptidyl tyrosine phosphorylation	GO:0018108	24	0.012
establishment or maintenance of cell polarity	GO:0007163	167	0.012
negative regulation of protein tyrosine kinase activity	GO:0061099	5	0.012
catecholamine biosynthetic process	GO:0042423	3	0.012
regulation of heart contraction	GO:0008016	21	0.012
cellular response to chemical stimulus	GO:0070887	199	0.012
eye development	GO:0001654	323	0.012
regulation of nervous system development	GO:0051960	248	0.011
hippo signaling	GO:0035329	20	0.011
endoderm formation	GO:0001706	3	0.011
oocyte development	GO:0048599	124	0.011
chromatin remodeling	GO:0006338	72	0.011
stress activated mapk cascade	GO:0051403	52	0.011
cellular protein localization	GO:0034613	160	0.011
macromolecular complex assembly	GO:0065003	256	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011
mrna metabolic process	GO:0016071	124	0.011
regulation of epithelial cell migration	GO:0010632	12	0.011
gastrulation	GO:0007369	70	0.011
modification dependent protein catabolic process	GO:0019941	78	0.011
positive regulation of protein transport	GO:0051222	37	0.011
development of primary female sexual characteristics	GO:0046545	12	0.011
negative regulation of cell cycle	GO:0045786	116	0.011
positive regulation of cell cycle	GO:0045787	43	0.011
guanosine containing compound metabolic process	GO:1901068	74	0.011
response to oxygen levels	GO:0070482	59	0.011
regulation of defense response	GO:0031347	102	0.011
positive regulation of rna biosynthetic process	GO:1902680	266	0.011
regulation of oocyte development	GO:0060281	27	0.011
intercellular bridge organization	GO:0043063	14	0.011
aging	GO:0007568	143	0.011
organophosphate metabolic process	GO:0019637	195	0.011
determination of adult lifespan	GO:0008340	137	0.011
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.011
homophilic cell adhesion via plasma membrane adhesion molecules	GO:0007156	18	0.011
multi organism behavior	GO:0051705	175	0.011
regulation of cell substrate adhesion	GO:0010810	2	0.011
negative regulation of wnt signaling pathway	GO:0030178	28	0.011
ribonucleotide catabolic process	GO:0009261	109	0.011
nucleotide catabolic process	GO:0009166	109	0.011
ras protein signal transduction	GO:0007265	88	0.011
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.011
regulation of stress activated mapk cascade	GO:0032872	41	0.011
cell recognition	GO:0008037	102	0.011
regulation of nucleotide catabolic process	GO:0030811	48	0.011
cognition	GO:0050890	141	0.011
cellular homeostasis	GO:0019725	80	0.011
epithelial cell migration open tracheal system	GO:0007427	32	0.011
regulation of developmental growth	GO:0048638	174	0.011
protein targeting	GO:0006605	64	0.011
regulation of kinase activity	GO:0043549	53	0.011
proteasomal protein catabolic process	GO:0010498	59	0.011
positive regulation of catabolic process	GO:0009896	105	0.011
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.010
dna metabolic process	GO:0006259	227	0.010
cellular catabolic process	GO:0044248	372	0.010
carbohydrate metabolic process	GO:0005975	82	0.010
developmental pigmentation	GO:0048066	68	0.010
muscle cell differentiation	GO:0042692	103	0.010
nucleoside triphosphate metabolic process	GO:0009141	120	0.010
regulation of nucleotide metabolic process	GO:0006140	62	0.010
aromatic compound catabolic process	GO:0019439	166	0.010
germline ring canal formation	GO:0030725	13	0.010
lipid metabolic process	GO:0006629	121	0.010
macromolecule glycosylation	GO:0043413	32	0.010
positive regulation of cellular catabolic process	GO:0031331	95	0.010
negative regulation of transferase activity	GO:0051348	18	0.010
detection of stimulus	GO:0051606	156	0.010
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.010
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.010
malpighian tubule development	GO:0072002	64	0.010

Megalin disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.013
cardiovascular system disease	DOID:1287	0.013
integumentary system disease	DOID:16	0.012

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