IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Nup154 (Dmel_CG4579)

Nucleoporin 154

(Aliases: Dmel\CG4579,l(2)01501,zk,Nup32D,tip,BcDNA:LD21772,nup32D,CG4579,tlp,ms(2)zk,l(2)10432,nup154)

Entrez: 34527
FLYBASE: FBgn0021761
UniProtKB: Q9V463

Process Predictions
Disease Predictions

Nup154 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular component assembly involved in morphogenesis	GO:0010927	151	0.986
dna conformation change	GO:0071103	105	0.840
germ line cyst formation	GO:0048134	44	0.836
eggshell chorion assembly	GO:0007306	66	0.807
pole plasm assembly	GO:0007315	61	0.793
eggshell formation	GO:0030703	105	0.775
catabolic process	GO:0009056	409	0.774
chorion containing eggshell formation	GO:0007304	105	0.737
establishment of localization in cell	GO:0051649	402	0.729	Mouse Worm
cellular catabolic process	GO:0044248	372	0.672
spermatogenesis	GO:0007283	200	0.656
dorsal appendage formation	GO:0046843	47	0.629
macromolecular complex assembly	GO:0065003	256	0.592
epithelial cell differentiation	GO:0030855	322	0.589
cystoblast division	GO:0007282	10	0.578
cytoplasmic transport	GO:0016482	130	0.532	Mouse
heterocycle catabolic process	GO:0046700	166	0.518
chromosome condensation	GO:0030261	41	0.480
nucleobase containing compound catabolic process	GO:0034655	165	0.480
spermatid differentiation	GO:0048515	114	0.475
female germ line cyst formation	GO:0048135	42	0.474
mrna metabolic process	GO:0016071	124	0.467
germarium derived female germ line cyst formation	GO:0030727	42	0.450
cell proliferation	GO:0008283	299	0.443
dna metabolic process	GO:0006259	227	0.397
dna packaging	GO:0006323	91	0.373
germarium derived egg chamber formation	GO:0007293	101	0.355
organic substance transport	GO:0071702	257	0.336	Mouse
protein localization	GO:0008104	284	0.333	Mouse
centrosome cycle	GO:0007098	137	0.324
centrosome organization	GO:0051297	163	0.312
oocyte construction	GO:0007308	112	0.310
organelle assembly	GO:0070925	198	0.308
organelle fission	GO:0048285	340	0.293
negative regulation of oskar mrna translation	GO:0007319	5	0.291
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.290
regulation of cell differentiation	GO:0045595	302	0.275
localization of cell	GO:0051674	257	0.257
aromatic compound catabolic process	GO:0019439	166	0.247
microtubule organizing center organization	GO:0031023	168	0.238
cellular macromolecule localization	GO:0070727	220	0.231	Mouse
development of primary sexual characteristics	GO:0045137	50	0.228	Worm
nucleoside metabolic process	GO:0009116	127	0.228
negative regulation of developmental process	GO:0051093	201	0.227
developmental growth	GO:0048589	280	0.222
regulation of cellular catabolic process	GO:0031329	157	0.216
protein targeting	GO:0006605	64	0.215	Mouse
organic cyclic compound catabolic process	GO:1901361	168	0.204
cellular macromolecular complex assembly	GO:0034622	153	0.194
oocyte anterior posterior axis specification	GO:0007314	72	0.191
embryonic pattern specification	GO:0009880	174	0.188
posttranscriptional regulation of gene expression	GO:0010608	145	0.182
growth	GO:0040007	359	0.167
cellular nitrogen compound catabolic process	GO:0044270	165	0.161
male gamete generation	GO:0048232	201	0.153
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.149
negative regulation of gene expression	GO:0010629	387	0.149
carbohydrate derivative metabolic process	GO:1901135	217	0.149
mrna catabolic process	GO:0006402	33	0.143
muscle structure development	GO:0061061	224	0.142
single organism behavior	GO:0044708	391	0.141
macromolecule catabolic process	GO:0009057	161	0.141
mitotic spindle organization	GO:0007052	220	0.134
segmentation	GO:0035282	207	0.133
embryo development ending in birth or egg hatching	GO:0009792	152	0.132	Worm
negative regulation of translation	GO:0017148	28	0.130
regulation of meiotic cell cycle	GO:0051445	9	0.128
posttranscriptional gene silencing by rna	GO:0035194	45	0.126
establishment of protein localization	GO:0045184	163	0.124	Mouse
embryonic axis specification	GO:0000578	107	0.121
single organism cellular localization	GO:1902580	180	0.121	Mouse
exocrine system development	GO:0035272	162	0.120
mrna processing	GO:0006397	104	0.117
organic substance catabolic process	GO:1901575	308	0.117
nucleoside triphosphate metabolic process	GO:0009141	120	0.116
protein complex assembly	GO:0006461	200	0.116
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.111
oocyte dorsal ventral axis specification	GO:0007310	34	0.110
mitotic nuclear division	GO:0007067	213	0.108
regulation of oskar mrna translation	GO:0046011	8	0.107
cellular protein complex assembly	GO:0043623	71	0.104
chromosome organization	GO:0051276	360	0.103
negative regulation of cell differentiation	GO:0045596	143	0.102
purine containing compound metabolic process	GO:0072521	155	0.101
pole plasm protein localization	GO:0007318	10	0.099
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.096
nuclear pore organization	GO:0006999	1	0.095
protein import	GO:0017038	55	0.095	Mouse
nucleobase containing small molecule metabolic process	GO:0055086	174	0.095
single organism intracellular transport	GO:1902582	207	0.094	Mouse
purine nucleoside metabolic process	GO:0042278	127	0.092
body morphogenesis	GO:0010171	2	0.092
tissue morphogenesis	GO:0048729	297	0.088
glycosyl compound metabolic process	GO:1901657	127	0.088
purine nucleotide metabolic process	GO:0006163	146	0.088
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.087
epithelial cell development	GO:0002064	274	0.086
larval development	GO:0002164	104	0.084	Worm
protein complex biogenesis	GO:0070271	201	0.083
regulation of catabolic process	GO:0009894	170	0.083
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.083
oocyte maturation	GO:0001556	3	0.082
purine ribonucleotide metabolic process	GO:0009150	145	0.081
regulation of meiosis	GO:0040020	3	0.078
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.077
spermatid development	GO:0007286	98	0.077
ribonucleoside metabolic process	GO:0009119	127	0.076
gland development	GO:0048732	191	0.075
ribonucleoprotein complex assembly	GO:0022618	23	0.074
protein import into nucleus	GO:0006606	51	0.074	Mouse
lipid metabolic process	GO:0006629	121	0.073
sister chromatid segregation	GO:0000819	92	0.071
gene silencing by rna	GO:0031047	57	0.071
morphogenesis of an epithelium	GO:0002009	276	0.071
homeostatic process	GO:0042592	199	0.070
stem cell division	GO:0017145	69	0.070
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.070
glycosyl compound catabolic process	GO:1901658	112	0.070
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.069
germarium derived oocyte fate determination	GO:0007294	26	0.068
meiotic cell cycle	GO:0051321	171	0.068
mitotic sister chromatid segregation	GO:0000070	87	0.068
regulation of dna metabolic process	GO:0051052	34	0.068
gonad development	GO:0008406	50	0.067	Worm
cell motility	GO:0048870	251	0.066
purine containing compound catabolic process	GO:0072523	112	0.065
nucleocytoplasmic transport	GO:0006913	72	0.065	Mouse
cellular protein localization	GO:0034613	160	0.065	Mouse
ribonucleotide metabolic process	GO:0009259	145	0.064
protein localization to organelle	GO:0033365	82	0.062	Mouse
oocyte axis specification	GO:0007309	108	0.062
death	GO:0016265	284	0.062
negative regulation of signaling	GO:0023057	219	0.062
nucleoside catabolic process	GO:0009164	112	0.062
g2 m transition of mitotic cell cycle	GO:0000086	19	0.060
rna processing	GO:0006396	147	0.060
mitotic cell cycle phase transition	GO:0044772	138	0.058
single organism catabolic process	GO:0044712	228	0.058
rna splicing	GO:0008380	83	0.057
intracellular mrna localization	GO:0008298	66	0.057
head development	GO:0060322	135	0.056
purine ribonucleoside metabolic process	GO:0046128	127	0.056
organonitrogen compound catabolic process	GO:1901565	128	0.054
genitalia development	GO:0048806	26	0.053	Worm
nuclear division	GO:0000280	332	0.052
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.051
negative regulation of cellular biosynthetic process	GO:0031327	277	0.051
attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation	GO:0051316	1	0.051
anterior posterior axis specification	GO:0009948	109	0.050
nuclear transport	GO:0051169	72	0.049	Mouse
positive regulation of cell cycle	GO:0045787	43	0.049
chromosome segregation	GO:0007059	157	0.049
blastoderm segmentation	GO:0007350	159	0.049
purine ribonucleotide catabolic process	GO:0009154	109	0.048
organonitrogen compound metabolic process	GO:1901564	318	0.047
asymmetric cell division	GO:0008356	37	0.046
stem cell development	GO:0048864	79	0.046
regulation of localization	GO:0032879	275	0.044	Mouse
regulation of cell division	GO:0051302	72	0.043
carbohydrate derivative catabolic process	GO:1901136	118	0.043
endomembrane system organization	GO:0010256	119	0.043	Human
regulation of developmental growth	GO:0048638	174	0.043
cellular macromolecule catabolic process	GO:0044265	136	0.042
regulation of transposition	GO:0010528	13	0.041
nucleoside triphosphate catabolic process	GO:0009143	108	0.039
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.039
purine ribonucleoside catabolic process	GO:0046130	112	0.039
negative regulation of mitotic anaphase promoting complex activity	GO:0060564	2	0.039
rna splicing via transesterification reactions	GO:0000375	73	0.039
translation	GO:0006412	69	0.039
karyosome formation	GO:0030717	22	0.039
salivary gland morphogenesis	GO:0007435	145	0.037
germ line stem cell division	GO:0042078	25	0.037
salivary gland development	GO:0007431	162	0.036
vesicle mediated transport	GO:0016192	381	0.036
ribose phosphate metabolic process	GO:0019693	145	0.036
ribonucleoside catabolic process	GO:0042454	112	0.035
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.035
establishment or maintenance of cell polarity	GO:0007163	167	0.034
regulation of cellular localization	GO:0060341	136	0.034
anterior posterior axis specification embryo	GO:0008595	103	0.033
mitotic cell cycle embryonic	GO:0045448	38	0.033
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded	GO:0008070	2	0.032
protein transport	GO:0015031	155	0.032	Mouse
axoneme assembly	GO:0035082	18	0.031
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.030
lateral inhibition	GO:0046331	206	0.030
purine nucleoside catabolic process	GO:0006152	112	0.029
response to wounding	GO:0009611	94	0.029
positive regulation of hydrolase activity	GO:0051345	78	0.029
ovarian follicle cell development	GO:0030707	248	0.029
chromosome organization involved in meiosis	GO:0070192	10	0.029
ribonucleotide catabolic process	GO:0009261	109	0.028
organelle inheritance	GO:0048308	2	0.028
actin cytoskeleton organization	GO:0030036	206	0.028
maintenance of protein location	GO:0045185	28	0.028
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.027
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.027
nucleoside phosphate catabolic process	GO:1901292	110	0.027
gene silencing	GO:0016458	138	0.027
organophosphate metabolic process	GO:0019637	195	0.027
smad protein import into nucleus	GO:0007184	11	0.026
nucleotide catabolic process	GO:0009166	109	0.026
immune system process	GO:0002376	347	0.026
sex differentiation	GO:0007548	81	0.026	Worm
ribonucleoprotein complex subunit organization	GO:0071826	28	0.026
endocytosis	GO:0006897	310	0.026
regulation of neurogenesis	GO:0050767	158	0.026
regulation of mrna metabolic process	GO:1903311	72	0.026
male meiosis	GO:0007140	52	0.026
digestive tract morphogenesis	GO:0048546	127	0.026
protein targeting to nucleus	GO:0044744	51	0.025	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.025
stem cell maintenance	GO:0019827	67	0.025
negative regulation of cellular component organization	GO:0051129	108	0.025
regulation of cell cycle	GO:0051726	291	0.025
secretion	GO:0046903	109	0.025	Worm
posttranscriptional gene silencing	GO:0016441	46	0.025
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.024
regulation of cell proliferation	GO:0042127	163	0.024
organophosphate catabolic process	GO:0046434	112	0.024
compound eye development	GO:0048749	307	0.024
small molecule metabolic process	GO:0044281	305	0.023
rna interference	GO:0016246	27	0.023
regulation of transport	GO:0051049	181	0.023
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.023
nucleoside monophosphate catabolic process	GO:0009125	39	0.023
urogenital system development	GO:0001655	72	0.023
positive regulation of multicellular organismal process	GO:0051240	143	0.023
maintenance of location	GO:0051235	73	0.022	Worm
mitotic chromosome condensation	GO:0007076	22	0.022
negative regulation of cellular metabolic process	GO:0031324	382	0.022
negative regulation of nurse cell apoptotic process	GO:0045849	2	0.021
nucleus organization	GO:0006997	45	0.021	Human Worm
negative regulation of nucleotide metabolic process	GO:0045980	4	0.021
dna replication	GO:0006260	48	0.021
digestive system development	GO:0055123	149	0.021
chromatin remodeling	GO:0006338	72	0.020
positive regulation of developmental process	GO:0051094	143	0.020
nucleoside monophosphate metabolic process	GO:0009123	52	0.020
imaginal disc growth	GO:0007446	37	0.020
fertilization	GO:0009566	26	0.020
nucleotide metabolic process	GO:0009117	161	0.020
regulation of striated muscle contraction	GO:0006942	2	0.020	Mouse
organ growth	GO:0035265	56	0.020
regulation of multicellular organismal development	GO:2000026	414	0.020
regulation of intracellular transport	GO:0032386	64	0.019
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.019
cellular response to nutrient	GO:0031670	1	0.019
positive regulation of catabolic process	GO:0009896	105	0.019
regulation of gene expression epigenetic	GO:0040029	128	0.019
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.019
dendrite regeneration	GO:0031104	2	0.019
ubiquitin dependent protein catabolic process	GO:0006511	78	0.018
embryonic morphogenesis	GO:0048598	206	0.018
regulation of response to stress	GO:0080134	200	0.018
axon development	GO:0061564	297	0.018
regulation of hemocyte proliferation	GO:0035206	37	0.017
hindgut development	GO:0061525	58	0.017
stem cell differentiation	GO:0048863	117	0.017
alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor clustering	GO:0097113	2	0.017
gland morphogenesis	GO:0022612	145	0.017
negative regulation of cellular protein metabolic process	GO:0032269	85	0.017
regulation of cell cycle phase transition	GO:1901987	130	0.017
negative regulation of response to stimulus	GO:0048585	258	0.017
regulation of cellular protein metabolic process	GO:0032268	243	0.017
regulation of establishment of protein localization	GO:0070201	61	0.016
positive regulation of cell differentiation	GO:0045597	64	0.016
regulation of histone methylation	GO:0031060	10	0.016
regulation of molecular function	GO:0065009	217	0.016
compound eye morphogenesis	GO:0001745	249	0.015
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.015
protein catabolic process	GO:0030163	101	0.015
nuclear transcribed mrna catabolic process	GO:0000956	24	0.015
spindle organization	GO:0007051	253	0.015
central nervous system development	GO:0007417	201	0.015
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.015
muscle cell differentiation	GO:0042692	103	0.015
histone h3 k9 modification	GO:0061647	12	0.015
chromatin assembly or disassembly	GO:0006333	52	0.015
establishment of ommatidial planar polarity	GO:0042067	49	0.015
intracellular protein transport	GO:0006886	104	0.015	Mouse
neuroblast proliferation	GO:0007405	74	0.014
cellular response to dna damage stimulus	GO:0006974	223	0.014
regulation of phosphorus metabolic process	GO:0051174	210	0.014
nucleoside phosphate metabolic process	GO:0006753	162	0.014
regulation of nucleoside metabolic process	GO:0009118	50	0.014
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.014
establishment of nucleus localization	GO:0040023	26	0.014
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.014
photoreceptor cell differentiation	GO:0046530	170	0.014
positive regulation of biosynthetic process	GO:0009891	316	0.014
positive regulation of molecular function	GO:0044093	136	0.014
chitin based larval cuticle pattern formation	GO:0035293	11	0.013
regulation of cellular component biogenesis	GO:0044087	201	0.013
regulation of hydrolase activity	GO:0051336	97	0.013
positive regulation of catalytic activity	GO:0043085	118	0.013
positive regulation of response to stimulus	GO:0048584	323	0.013
meiotic dna repair synthesis	GO:0000711	3	0.013
positive regulation of mitotic cell cycle	GO:0045931	34	0.012
epithelial cell fate determination open tracheal system	GO:0007425	2	0.012
oocyte morphogenesis	GO:0048601	3	0.012
eye development	GO:0001654	323	0.012
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.012
nuclear envelope organization	GO:0006998	7	0.012	Human
regulation of cdc42 protein signal transduction	GO:0032489	3	0.012
positive regulation of cell development	GO:0010720	61	0.012
eye morphogenesis	GO:0048592	260	0.012
single organism nuclear import	GO:1902593	51	0.012	Mouse
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.012
carboxylic acid metabolic process	GO:0019752	92	0.011
nitrogen compound transport	GO:0071705	85	0.011	Mouse
locomotory behavior	GO:0007626	176	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.011
lymph gland development	GO:0048542	28	0.011
positive regulation of multicellular organism growth	GO:0040018	21	0.011
ion transport	GO:0006811	145	0.011
regulation of viral genome replication	GO:0045069	4	0.011
dorsal closure leading edge cell differentiation	GO:0046663	2	0.011
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.011
regulation of proteasomal protein catabolic process	GO:0061136	39	0.011
oenocyte delamination	GO:0060233	2	0.011
tube development	GO:0035295	244	0.011
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.011
chromatin modification	GO:0016568	147	0.011
pole plasm mrna localization	GO:0019094	49	0.011
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.010
axis specification	GO:0009798	167	0.010
regulation of transmembrane transport	GO:0034762	27	0.010
centriole replication	GO:0007099	24	0.010
meiotic cell cycle process	GO:1903046	132	0.010
regulation of mrna splicing via spliceosome	GO:0048024	64	0.010
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	2	0.010
regulation of rna splicing	GO:0043484	69	0.010
negative regulation of terminal cell fate specification open tracheal system	GO:0035155	2	0.010

Nup154 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
syndrome	DOID:225	0.033
disease of cellular proliferation	DOID:14566	0.026
cancer	DOID:162	0.026
organ system cancer	DOID:0050686	0.016

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network