IMP: Integrative Multi-species Prediction

Drosophila melanogaster

18 known processes

her (Dmel_CG4694)

hermaphrodite

(Aliases: l(2)mat,CG4694,Dmel\CG4694)

Entrez: 34992
FLYBASE: FBgn0001185
UniProtKB: Q9VJJ6

Process Predictions
Disease Predictions

her biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
positive regulation of rna metabolic process	GO:0051254	271	0.422
response to organic substance	GO:0010033	284	0.326
regulation of gene expression epigenetic	GO:0040029	128	0.321
taxis	GO:0042330	304	0.254
axonogenesis	GO:0007409	290	0.253
mating	GO:0007618	120	0.219
camera type eye development	GO:0043010	4	0.202
response to light stimulus	GO:0009416	124	0.164
peptidyl lysine acetylation	GO:0018394	39	0.156
epithelial cell development	GO:0002064	274	0.141
tube development	GO:0035295	244	0.121
regulation of intracellular signal transduction	GO:1902531	236	0.116
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.114
regionalization	GO:0003002	416	0.114
developmental maturation	GO:0021700	172	0.112
axon guidance	GO:0007411	233	0.111
germ cell migration	GO:0008354	43	0.107
positive regulation of molecular function	GO:0044093	136	0.100
regulation of cellular amine metabolic process	GO:0033238	3	0.097
sensory perception of sound	GO:0007605	56	0.096
positive regulation of biosynthetic process	GO:0009891	316	0.096
meiotic chromosome segregation	GO:0045132	59	0.095
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.094
cell motility	GO:0048870	251	0.094
gene silencing	GO:0016458	138	0.093
chemotaxis	GO:0006935	249	0.093
regulation of mitotic cell cycle	GO:0007346	190	0.092
ovarian follicle cell development	GO:0030707	248	0.092
regulation of cell cycle process	GO:0010564	181	0.092
cell maturation	GO:0048469	144	0.091
striated muscle cell development	GO:0055002	50	0.089
respiratory system development	GO:0060541	213	0.087
sensory perception of mechanical stimulus	GO:0050954	72	0.084
positive regulation of cellular biosynthetic process	GO:0031328	316	0.084
regulation of localization	GO:0032879	275	0.083
regulation of cell morphogenesis	GO:0022604	163	0.081
body morphogenesis	GO:0010171	2	0.079
macromolecule catabolic process	GO:0009057	161	0.074
apoptotic cell clearance	GO:0043277	14	0.074
internal protein amino acid acetylation	GO:0006475	38	0.073
male meiosis chromosome segregation	GO:0007060	10	0.073
cellular catabolic process	GO:0044248	372	0.073
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.070
multicellular organismal reproductive behavior	GO:0033057	110	0.070
negative regulation of cellular metabolic process	GO:0031324	382	0.069
cellular protein modification process	GO:0006464	438	0.068
epithelial cell differentiation	GO:0030855	322	0.068
axon development	GO:0061564	297	0.065
positive regulation of transcription dna templated	GO:0045893	266	0.065
death	GO:0016265	284	0.064
reproductive behavior	GO:0019098	122	0.064
peptidyl lysine modification	GO:0018205	57	0.063
neuron projection guidance	GO:0097485	241	0.063
fertilization	GO:0009566	26	0.062
neuron recognition	GO:0008038	101	0.061
nucleobase containing compound catabolic process	GO:0034655	165	0.061
larval development	GO:0002164	104	0.059
tripartite regional subdivision	GO:0007351	103	0.058
regulation of cellular amino acid metabolic process	GO:0006521	0	0.057
regulation of cell cycle	GO:0051726	291	0.056
apoptotic process	GO:0006915	159	0.056
kidney development	GO:0001822	3	0.053
male mating behavior	GO:0060179	70	0.053
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.053
regulation of cellular ketone metabolic process	GO:0010565	3	0.052
cell junction organization	GO:0034330	57	0.052
proteolysis	GO:0006508	192	0.052
internal peptidyl lysine acetylation	GO:0018393	38	0.051
exocrine system development	GO:0035272	162	0.050
regulation of anatomical structure size	GO:0090066	163	0.050
cellular component assembly involved in morphogenesis	GO:0010927	151	0.049
epithelial tube morphogenesis	GO:0060562	88	0.049
protein acetylation	GO:0006473	39	0.049
mating behavior	GO:0007617	106	0.049
negative regulation of cell cycle	GO:0045786	116	0.048
embryonic axis specification	GO:0000578	107	0.047
axis specification	GO:0009798	167	0.047
chromatin remodeling	GO:0006338	72	0.046
mitotic g2 m transition checkpoint	GO:0044818	70	0.046
programmed cell death	GO:0012501	257	0.046
response to abiotic stimulus	GO:0009628	341	0.046
covalent chromatin modification	GO:0016569	106	0.046
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.044
negative regulation of gene expression	GO:0010629	387	0.044
cell junction assembly	GO:0034329	42	0.044
positive regulation of rna biosynthetic process	GO:1902680	266	0.043
regulation of protein localization	GO:0032880	76	0.043
renal system development	GO:0072001	72	0.043
regulation of molecular function	GO:0065009	217	0.042
renal tubule development	GO:0061326	64	0.042
cell cycle phase transition	GO:0044770	140	0.042
localization of cell	GO:0051674	257	0.042
negative regulation of cell cycle process	GO:0010948	109	0.041
gene silencing by rna	GO:0031047	57	0.041
cellular macromolecule localization	GO:0070727	220	0.041
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.041
immune system process	GO:0002376	347	0.041
phosphorylation	GO:0016310	294	0.040
embryonic morphogenesis	GO:0048598	206	0.040
positive regulation of multicellular organismal process	GO:0051240	143	0.040
histone h4 acetylation	GO:0043967	13	0.040
muscle cell development	GO:0055001	50	0.039
chitin based cuticle sclerotization	GO:0007593	19	0.038
gland morphogenesis	GO:0022612	145	0.038
multi organism reproductive behavior	GO:0044705	121	0.038
purine ribonucleotide metabolic process	GO:0009150	145	0.037
oocyte differentiation	GO:0009994	145	0.037
developmental growth involved in morphogenesis	GO:0060560	65	0.037
multi multicellular organism process	GO:0044706	123	0.036
positive regulation of macromolecule metabolic process	GO:0010604	405	0.036
branching morphogenesis of an epithelial tube	GO:0048754	45	0.036
regulation of cell proliferation	GO:0042127	163	0.035
histone h4 k16 acetylation	GO:0043984	4	0.035
male courtship behavior	GO:0008049	63	0.035
posttranscriptional regulation of gene expression	GO:0010608	145	0.035
sex determination	GO:0007530	18	0.035
cell growth	GO:0016049	108	0.035
cellular protein catabolic process	GO:0044257	83	0.034
head development	GO:0060322	135	0.034
sensory organ morphogenesis	GO:0090596	260	0.034
homeostatic process	GO:0042592	199	0.034
organonitrogen compound metabolic process	GO:1901564	318	0.034
peptidyl amino acid modification	GO:0018193	105	0.033
tube morphogenesis	GO:0035239	191	0.033
cell projection assembly	GO:0030031	94	0.033
anterior posterior axis specification embryo	GO:0008595	103	0.033
dosage compensation	GO:0007549	16	0.032
positive regulation of signal transduction	GO:0009967	223	0.032
morphogenesis of embryonic epithelium	GO:0016331	94	0.032
negative regulation of cell death	GO:0060548	81	0.031
meiotic cell cycle process	GO:1903046	132	0.031
intracellular signal transduction	GO:0035556	300	0.030
regulation of nuclear division	GO:0051783	58	0.030
secondary metabolic process	GO:0019748	75	0.030
mitotic cell cycle phase transition	GO:0044772	138	0.030
heart development	GO:0007507	82	0.030
cell proliferation	GO:0008283	299	0.029
cardiovascular system development	GO:0072358	82	0.029
protein localization	GO:0008104	284	0.029
compound eye development	GO:0048749	307	0.028
oocyte maturation	GO:0001556	3	0.028
regulation of cell division	GO:0051302	72	0.028
nucleotide metabolic process	GO:0009117	161	0.028
positive regulation of mapk cascade	GO:0043410	63	0.027
eye morphogenesis	GO:0048592	260	0.027
organophosphate biosynthetic process	GO:0090407	46	0.027
morphogenesis of a branching epithelium	GO:0061138	45	0.027
transcription from rna polymerase ii promoter	GO:0006366	368	0.027
establishment of nucleus localization	GO:0040023	26	0.027
cellular response to dna damage stimulus	GO:0006974	223	0.027
phagocytosis	GO:0006909	215	0.027
organic substance catabolic process	GO:1901575	308	0.027
protein complex biogenesis	GO:0070271	201	0.027
multi organism behavior	GO:0051705	175	0.027
endocytosis	GO:0006897	310	0.027
cell migration	GO:0016477	238	0.026
mitotic cell cycle checkpoint	GO:0007093	88	0.026
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.026
organelle fission	GO:0048285	340	0.026
negative regulation of cell cycle phase transition	GO:1901988	103	0.025
catabolic process	GO:0009056	409	0.025
cell recognition	GO:0008037	102	0.025
positive regulation of protein secretion	GO:0050714	9	0.025
urogenital system development	GO:0001655	72	0.025
regulation of cell cycle phase transition	GO:1901987	130	0.025
determination of adult lifespan	GO:0008340	137	0.025
dendrite morphogenesis	GO:0048813	199	0.025
cellular macromolecule catabolic process	GO:0044265	136	0.025
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.025
eye development	GO:0001654	323	0.024
negative regulation of signal transduction	GO:0009968	206	0.024
regulation of synapse structure and activity	GO:0050803	128	0.024
response to radiation	GO:0009314	155	0.024
morphogenesis of a branching structure	GO:0001763	45	0.024
regulation of mapk cascade	GO:0043408	92	0.024
nucleobase containing small molecule metabolic process	GO:0055086	174	0.024
positive regulation of phosphorylation	GO:0042327	87	0.024
nuclear division	GO:0000280	332	0.023
regulation of organelle organization	GO:0033043	196	0.023
protein processing	GO:0016485	68	0.022
cellular response to organic substance	GO:0071310	132	0.022
chromosome organization	GO:0051276	360	0.022
cell cycle checkpoint	GO:0000075	95	0.022
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.022
anterior posterior pattern specification	GO:0009952	136	0.021
circulatory system development	GO:0072359	82	0.021
chromosome segregation	GO:0007059	157	0.021
amine metabolic process	GO:0009308	12	0.021
transmembrane transport	GO:0055085	139	0.021
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.021
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.021
actin cytoskeleton organization	GO:0030036	206	0.021
multicellular organismal aging	GO:0010259	140	0.020
female germ line cyst formation	GO:0048135	42	0.020
pole plasm assembly	GO:0007315	61	0.020
protein catabolic process	GO:0030163	101	0.020
cytoplasm organization	GO:0007028	64	0.020
male courtship behavior veined wing extension	GO:0048065	22	0.020
kidney morphogenesis	GO:0060993	3	0.020
anterior posterior axis specification	GO:0009948	109	0.020
signal transduction by phosphorylation	GO:0023014	107	0.020
stress activated protein kinase signaling cascade	GO:0031098	55	0.020
negative regulation of apoptotic process	GO:0043066	63	0.020
salivary gland development	GO:0007431	162	0.019
germarium derived female germ line cyst formation	GO:0030727	42	0.019
purine nucleotide metabolic process	GO:0006163	146	0.019
lipid storage	GO:0019915	38	0.019
rna processing	GO:0006396	147	0.019
negative regulation of response to stimulus	GO:0048585	258	0.019
embryonic organ development	GO:0048568	50	0.019
organic cyclic compound catabolic process	GO:1901361	168	0.019
dna repair	GO:0006281	54	0.019
protein phosphorylation	GO:0006468	169	0.019
open tracheal system development	GO:0007424	204	0.019
negative regulation of rna metabolic process	GO:0051253	251	0.019
positive regulation of signaling	GO:0023056	243	0.019
establishment of protein localization	GO:0045184	163	0.019
tissue morphogenesis	GO:0048729	297	0.018
positive regulation of cell motility	GO:2000147	3	0.018
central nervous system development	GO:0007417	201	0.018
vesicle mediated transport	GO:0016192	381	0.018
regulation of phosphorus metabolic process	GO:0051174	210	0.018
regulation of gene silencing	GO:0060968	63	0.018
muscle fiber development	GO:0048747	12	0.017
ribonucleotide metabolic process	GO:0009259	145	0.017
adult behavior	GO:0030534	137	0.017
nucleoside phosphate metabolic process	GO:0006753	162	0.017
negative regulation of gene expression epigenetic	GO:0045814	77	0.017
ribonucleotide biosynthetic process	GO:0009260	28	0.017
response to oxidative stress	GO:0006979	86	0.017
skeletal muscle fiber development	GO:0048741	3	0.017
regulation of immune system process	GO:0002682	176	0.017
regulation of response to stress	GO:0080134	200	0.017
aging	GO:0007568	143	0.017
smoothened signaling pathway	GO:0007224	49	0.017
regulation of embryonic development	GO:0045995	68	0.017
atp metabolic process	GO:0046034	49	0.016
cellular amine metabolic process	GO:0044106	12	0.016
female meiotic division	GO:0007143	70	0.016
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.016
regulation of cellular component size	GO:0032535	98	0.016
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.016
organophosphate metabolic process	GO:0019637	195	0.016
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.016
regulation of cell shape	GO:0008360	113	0.016
actin filament organization	GO:0007015	126	0.016
dendrite development	GO:0016358	204	0.016
regulation of purine nucleotide metabolic process	GO:1900542	62	0.015
digestive tract morphogenesis	GO:0048546	127	0.015
negative regulation of cellular protein metabolic process	GO:0032269	85	0.015
cell death	GO:0008219	279	0.015
positive regulation of gene expression	GO:0010628	290	0.015
chromatin organization	GO:0006325	207	0.015
protein modification process	GO:0036211	438	0.015
chromatin modification	GO:0016568	147	0.015
protein import	GO:0017038	55	0.015
positive regulation of lipid metabolic process	GO:0045834	4	0.015
intercellular transport	GO:0010496	2	0.015
actin filament based process	GO:0030029	220	0.015
regulation of reproductive process	GO:2000241	54	0.015
negative regulation of multicellular organismal process	GO:0051241	142	0.015
striated muscle tissue development	GO:0014706	27	0.015
positive regulation of cell size	GO:0045793	21	0.015
regulation of cell size	GO:0008361	63	0.015
positive regulation of phosphate metabolic process	GO:0045937	139	0.015
dna integrity checkpoint	GO:0031570	81	0.015
reproductive system development	GO:0061458	74	0.015
photoreceptor cell differentiation	GO:0046530	170	0.015
hematopoietic or lymphoid organ development	GO:0048534	57	0.014
regulation of cellular catabolic process	GO:0031329	157	0.014
retina development in camera type eye	GO:0060041	4	0.014
positive regulation of wnt signaling pathway	GO:0030177	25	0.014
negative regulation of cell proliferation	GO:0008285	69	0.014
cell cell junction assembly	GO:0007043	38	0.014
response to extracellular stimulus	GO:0009991	116	0.014
protein acylation	GO:0043543	42	0.014
positive regulation of phosphorus metabolic process	GO:0010562	139	0.014
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.014
cellular response to chemical stimulus	GO:0070887	199	0.014
regulation of protein metabolic process	GO:0051246	256	0.014
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.014
ras protein signal transduction	GO:0007265	88	0.014
negative regulation of cellular biosynthetic process	GO:0031327	277	0.014
dorsal closure	GO:0007391	79	0.014
oocyte axis specification	GO:0007309	108	0.014
hemocyte migration	GO:0035099	19	0.014
posttranscriptional gene silencing	GO:0016441	46	0.014
blastoderm segmentation	GO:0007350	159	0.013
regulation of membrane depolarization	GO:0003254	1	0.013
membrane depolarization	GO:0051899	4	0.013
oocyte development	GO:0048599	124	0.013
positive regulation of response to stimulus	GO:0048584	323	0.013
regulation of cellular protein metabolic process	GO:0032268	243	0.013
tube formation	GO:0035148	21	0.013
mitotic spindle organization	GO:0007052	220	0.013
courtship behavior	GO:0007619	68	0.013
regulation of organ morphogenesis	GO:2000027	78	0.013
protein kinase b signaling	GO:0043491	1	0.013
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.013
neuromuscular process	GO:0050905	21	0.013
regulation of establishment of protein localization	GO:0070201	61	0.013
neurological system process	GO:0050877	358	0.013
cellular homeostasis	GO:0019725	80	0.013
negative regulation of programmed cell death	GO:0043069	72	0.013
eggshell chorion assembly	GO:0007306	66	0.012
carbohydrate derivative metabolic process	GO:1901135	217	0.012
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.012
nucleoside phosphate catabolic process	GO:1901292	110	0.012
nuclear migration	GO:0007097	20	0.012
regulation of mitosis	GO:0007088	56	0.012
regulation of phosphate metabolic process	GO:0019220	210	0.012
negative regulation of protein metabolic process	GO:0051248	85	0.012
anatomical structure homeostasis	GO:0060249	97	0.012
brain development	GO:0007420	120	0.012
digestive system development	GO:0055123	149	0.012
negative regulation of cell communication	GO:0010648	223	0.012
regulation of meiosis	GO:0040020	3	0.012
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.012
hindbrain development	GO:0030902	2	0.012
single organismal cell cell adhesion	GO:0016337	45	0.012
positive regulation of protein transport	GO:0051222	37	0.012
negative regulation of g2 m transition of mitotic cell cycle	GO:0010972	8	0.012
oocyte construction	GO:0007308	112	0.012
morphogenesis of a polarized epithelium	GO:0001738	93	0.011
positive regulation of growth	GO:0045927	75	0.011
regulation of cytoskeleton organization	GO:0051493	89	0.011
defense response to other organism	GO:0098542	225	0.011
embryonic development via the syncytial blastoderm	GO:0001700	148	0.011
chemosensory behavior	GO:0007635	106	0.011
border follicle cell migration	GO:0007298	113	0.011
macromolecular complex assembly	GO:0065003	256	0.011
regulation of developmental growth	GO:0048638	174	0.011
male courtship behavior veined wing vibration	GO:0016545	21	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011
response to organic cyclic compound	GO:0014070	89	0.011
skeletal muscle organ development	GO:0060538	48	0.011
positive regulation of catalytic activity	GO:0043085	118	0.011
regulation of transport	GO:0051049	181	0.011
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.011
camera type eye morphogenesis	GO:0048593	2	0.011
epidermis development	GO:0008544	65	0.011
negative regulation of phosphate metabolic process	GO:0045936	45	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.011
nucleoside triphosphate catabolic process	GO:0009143	108	0.011
purine ribonucleoside metabolic process	GO:0046128	127	0.011
glycosyl compound catabolic process	GO:1901658	112	0.011
positive regulation of intracellular signal transduction	GO:1902533	116	0.011
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.010
organelle assembly	GO:0070925	198	0.010
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.010
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.010
positive regulation of cellular protein metabolic process	GO:0032270	118	0.010
translation	GO:0006412	69	0.010
dna biosynthetic process	GO:0071897	24	0.010
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.010
histone acetylation	GO:0016573	38	0.010
multicellular organism growth	GO:0035264	46	0.010
positive regulation of transport	GO:0051050	92	0.010
regulation of stress activated mapk cascade	GO:0032872	41	0.010
modification dependent macromolecule catabolic process	GO:0043632	79	0.010
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.010
nephron development	GO:0072006	3	0.010

her disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.074
organ system cancer	DOID:0050686	0.074
cancer	DOID:162	0.074

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