IMP: Integrative Multi-species Prediction

Drosophila melanogaster

132 known processes

Wnt4 (Dmel_CG4698)

Wnt oncogene analog 4

(Aliases: Dmel\CG4698,CG4698,DWnt4,Wnt-4,clone 2.4,wnt4,DWnt-4,wnt-4,anon-EST:Liang-2.4,Wnt,Dwnt4)

Entrez: 34007
FLYBASE: FBgn0010453
UniProtKB: P40589
UniProtKB: D2NUH8

Process Predictions
Disease Predictions

Wnt4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
morphogenesis of an epithelium	GO:0002009	276	0.946
regionalization	GO:0003002	416	0.940	Fly
morphogenesis of a polarized epithelium	GO:0001738	93	0.928
chemotaxis	GO:0006935	249	0.906
wing disc morphogenesis	GO:0007472	344	0.902
stem cell maintenance	GO:0019827	67	0.881	Mouse
epithelial cell differentiation	GO:0030855	322	0.877
regulation of cell differentiation	GO:0045595	302	0.851	Mouse Fly
imaginal disc derived wing hair organization	GO:0035317	45	0.848
tissue morphogenesis	GO:0048729	297	0.842
neuron projection guidance	GO:0097485	241	0.790
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.786
axonogenesis	GO:0007409	290	0.772
imaginal disc derived wing morphogenesis	GO:0007476	337	0.750
establishment of ommatidial planar polarity	GO:0042067	49	0.741
hindgut morphogenesis	GO:0007442	58	0.727	Fly
negative regulation of cell differentiation	GO:0045596	143	0.721	Mouse Fly
digestive system development	GO:0055123	149	0.714	Fly
cell migration	GO:0016477	238	0.709
cell motility	GO:0048870	251	0.707
regulation of multicellular organismal development	GO:2000026	414	0.692
dendrite development	GO:0016358	204	0.692
imaginal disc derived appendage development	GO:0048737	399	0.691
establishment of tissue polarity	GO:0007164	87	0.675
cell proliferation	GO:0008283	299	0.667
taxis	GO:0042330	304	0.645
stem cell differentiation	GO:0048863	117	0.629	Mouse Fly
axon guidance	GO:0007411	233	0.627
sensory organ morphogenesis	GO:0090596	260	0.626	Fly
positive regulation of macromolecule metabolic process	GO:0010604	405	0.626
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.617
appendage morphogenesis	GO:0035107	397	0.614
embryonic pattern specification	GO:0009880	174	0.578	Fly
regulation of anatomical structure morphogenesis	GO:0022603	242	0.565
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.562
dendrite morphogenesis	GO:0048813	199	0.557
compound eye morphogenesis	GO:0001745	249	0.551	Fly
cell fate determination	GO:0001709	91	0.513
epithelial cell development	GO:0002064	274	0.510	Mouse Fly
developmental growth	GO:0048589	280	0.507	Fly
epithelial tube morphogenesis	GO:0060562	88	0.500	Mouse Fly
establishment of planar polarity	GO:0001736	87	0.494
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.481
tube development	GO:0035295	244	0.469	Mouse Fly
neuron fate commitment	GO:0048663	50	0.463
cell fate specification	GO:0001708	71	0.458	Fly
axis specification	GO:0009798	167	0.453
stem cell development	GO:0048864	79	0.447	Mouse Fly
post embryonic appendage morphogenesis	GO:0035120	385	0.440
positive regulation of multicellular organismal process	GO:0051240	143	0.428	Fly
digestive tract development	GO:0048565	149	0.424	Fly
dorsal ventral pattern formation	GO:0009953	133	0.421	Fly
localization of cell	GO:0051674	257	0.420
regulation of neurogenesis	GO:0050767	158	0.410
regulation of cell development	GO:0060284	215	0.409	Mouse Fly
eye morphogenesis	GO:0048592	260	0.406	Fly
regulation of nervous system development	GO:0051960	248	0.387
segmentation	GO:0035282	207	0.383	Fly
appendage development	GO:0048736	401	0.369
tissue migration	GO:0090130	155	0.369
ameboidal type cell migration	GO:0001667	151	0.362
wnt signaling pathway	GO:0016055	98	0.351
compound eye development	GO:0048749	307	0.347	Fly
blastoderm segmentation	GO:0007350	159	0.347	Fly
central nervous system development	GO:0007417	201	0.344	Fly
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.342	Fly
photoreceptor cell fate commitment	GO:0046552	41	0.337
establishment or maintenance of cell polarity	GO:0007163	167	0.336
compound eye photoreceptor fate commitment	GO:0001752	36	0.325
positive regulation of biosynthetic process	GO:0009891	316	0.323
growth	GO:0040007	359	0.323	Fly
gastrulation	GO:0007369	70	0.307	Fly
regulation of neuron projection development	GO:0010975	69	0.300
regulation of developmental growth	GO:0048638	174	0.299
retinal ganglion cell axon guidance	GO:0031290	12	0.295
hindgut development	GO:0061525	58	0.288	Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.281
transcription from rna polymerase ii promoter	GO:0006366	368	0.271
malpighian tubule development	GO:0072002	64	0.269	Fly
positive regulation of developmental process	GO:0051094	143	0.267	Mouse Fly
female sex differentiation	GO:0046660	20	0.255
digestive tract morphogenesis	GO:0048546	127	0.254	Fly
epithelial cell migration	GO:0010631	148	0.253
regulation of growth	GO:0040008	233	0.250
anterior posterior axis specification	GO:0009948	109	0.248
positive regulation of cell differentiation	GO:0045597	64	0.246	Mouse Fly
eye photoreceptor cell fate commitment	GO:0042706	37	0.246
olfactory behavior	GO:0042048	97	0.244
embryonic development via the syncytial blastoderm	GO:0001700	148	0.244	Fly
positive regulation of cell development	GO:0010720	61	0.240	Fly
negative regulation of transcription dna templated	GO:0045892	237	0.238	Fly
positive regulation of cellular biosynthetic process	GO:0031328	316	0.230
positive regulation of transcription dna templated	GO:0045893	266	0.229
negative regulation of signal transduction	GO:0009968	206	0.229
regulation of embryonic development	GO:0045995	68	0.226	Fly
negative regulation of cell communication	GO:0010648	223	0.224	Fly
cell maturation	GO:0048469	144	0.221
renal tubule development	GO:0061326	64	0.215	Mouse Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.214
epidermis development	GO:0008544	65	0.214
morphogenesis of embryonic epithelium	GO:0016331	94	0.210	Mouse Fly
tube morphogenesis	GO:0035239	191	0.208	Mouse Fly
formation of anatomical boundary	GO:0048859	37	0.192
immune system process	GO:0002376	347	0.190
negative regulation of developmental process	GO:0051093	201	0.190	Mouse Fly
embryonic organ development	GO:0048568	50	0.188	Zebrafish Mouse
negative regulation of nervous system development	GO:0051961	92	0.188
establishment of apical basal cell polarity	GO:0035089	12	0.187
germarium derived egg chamber formation	GO:0007293	101	0.184
cellular response to organic substance	GO:0071310	132	0.180
cell division	GO:0051301	248	0.176	Mouse
positive regulation of response to stimulus	GO:0048584	323	0.176	Mouse
intracellular signal transduction	GO:0035556	300	0.173
protein modification process	GO:0036211	438	0.172	Mouse
negative regulation of apoptotic process	GO:0043066	63	0.172	Mouse
forebrain development	GO:0030900	2	0.168
male gamete generation	GO:0048232	201	0.167
regulation of protein metabolic process	GO:0051246	256	0.166	Mouse
negative regulation of wnt signaling pathway	GO:0030178	28	0.164
regulation of organ morphogenesis	GO:2000027	78	0.162
tripartite regional subdivision	GO:0007351	103	0.155
negative regulation of cellular metabolic process	GO:0031324	382	0.155	Mouse Fly
imaginal disc derived wing vein specification	GO:0007474	48	0.154
reproductive system development	GO:0061458	74	0.153
embryonic hemopoiesis	GO:0035162	26	0.152
cardiovascular system development	GO:0072358	82	0.151	Fly
regulation of neuron differentiation	GO:0045664	103	0.150
embryonic axis specification	GO:0000578	107	0.149
photoreceptor cell differentiation	GO:0046530	170	0.142
developmental pigmentation	GO:0048066	68	0.141	Fly
salivary gland morphogenesis	GO:0007435	145	0.140
establishment or maintenance of monopolar cell polarity	GO:0061339	15	0.139
malpighian tubule morphogenesis	GO:0007443	44	0.138	Fly
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.138
circulatory system development	GO:0072359	82	0.137	Fly
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.136	Fly
convergent extension	GO:0060026	2	0.135
negative regulation of cellular biosynthetic process	GO:0031327	277	0.134	Fly
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.133	Fly
positive regulation of protein metabolic process	GO:0051247	128	0.133
torso signaling pathway	GO:0008293	21	0.132
negative regulation of signaling	GO:0023057	219	0.130	Fly
protein phosphorylation	GO:0006468	169	0.129	Mouse
biological adhesion	GO:0022610	138	0.129
cell cycle dna replication	GO:0044786	23	0.129	Fly
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.127
positive regulation of gene expression	GO:0010628	290	0.126
phosphorylation	GO:0016310	294	0.126	Mouse
positive regulation of cellular component organization	GO:0051130	156	0.123
reproductive structure development	GO:0048608	74	0.123
axon development	GO:0061564	297	0.123
motor neuron axon guidance	GO:0008045	58	0.122
eye development	GO:0001654	323	0.122
myotube cell development	GO:0014904	3	0.122
striated muscle cell differentiation	GO:0051146	90	0.121
regulation of anatomical structure size	GO:0090066	163	0.121	Mouse Fly
head development	GO:0060322	135	0.120
ommatidial rotation	GO:0016318	20	0.119
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.119
imaginal disc derived wing hair site selection	GO:0035320	4	0.118
positive regulation of nervous system development	GO:0051962	69	0.117
stem cell fate commitment	GO:0048865	25	0.117
muscle organ development	GO:0007517	127	0.116	Fly
anterior posterior pattern specification	GO:0009952	136	0.116	Fly
embryonic morphogenesis	GO:0048598	206	0.116	Zebrafish Mouse Fly
chromatin organization	GO:0006325	207	0.115
cell junction organization	GO:0034330	57	0.115
positive regulation of rna metabolic process	GO:0051254	271	0.115
catabolic process	GO:0009056	409	0.115
female gonad development	GO:0008585	12	0.112
eye photoreceptor cell differentiation	GO:0001754	145	0.111
compound eye photoreceptor cell differentiation	GO:0001751	140	0.111
positive regulation of cell projection organization	GO:0031346	29	0.110
muscle structure development	GO:0061061	224	0.110	Fly
regulation of protein modification process	GO:0031399	112	0.109	Mouse
regulation of multicellular organism growth	GO:0040014	40	0.109
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.108
establishment of epithelial cell apical basal polarity	GO:0045198	10	0.108
anterior posterior axis specification embryo	GO:0008595	103	0.107
regulation of tube architecture open tracheal system	GO:0035152	68	0.106
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.104
negative regulation of biosynthetic process	GO:0009890	277	0.103	Fly
cell cell junction organization	GO:0045216	55	0.102
chromosome organization	GO:0051276	360	0.100
sex differentiation	GO:0007548	81	0.100
neuron migration	GO:0001764	5	0.099
oocyte axis specification	GO:0007309	108	0.097
axon midline choice point recognition	GO:0016199	26	0.097
regulation of heart morphogenesis	GO:2000826	3	0.096	Fly
neuron fate specification	GO:0048665	12	0.095
regulation of cellular protein metabolic process	GO:0032268	243	0.095	Mouse
response to alcohol	GO:0097305	95	0.094
skeletal muscle fiber development	GO:0048741	3	0.094
segment specification	GO:0007379	33	0.094
negative regulation of neurogenesis	GO:0050768	53	0.092
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.091
axon choice point recognition	GO:0016198	26	0.090
cell adhesion	GO:0007155	136	0.090
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.089
signal transduction by phosphorylation	GO:0023014	107	0.089
regulation of synapse structure and activity	GO:0050803	128	0.089
positive regulation of cell proliferation	GO:0008284	47	0.088	Fly
negative regulation of rna metabolic process	GO:0051253	251	0.088	Fly
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.088	Fly
gland development	GO:0048732	191	0.087
regulation of cell projection organization	GO:0031344	92	0.087
negative regulation of cell death	GO:0060548	81	0.085	Mouse
establishment of cell polarity	GO:0030010	40	0.085
positive regulation of neurogenesis	GO:0050769	41	0.083
response to organic substance	GO:0010033	284	0.083
positive regulation of catabolic process	GO:0009896	105	0.082
developmental programmed cell death	GO:0010623	138	0.082	Fly
neural precursor cell proliferation	GO:0061351	75	0.081
convergent extension involved in gastrulation	GO:0060027	2	0.080
regulation of wnt signaling pathway	GO:0030111	68	0.080
proteolysis	GO:0006508	192	0.080	Mouse
response to oxygen containing compound	GO:1901700	200	0.080
organ formation	GO:0048645	39	0.080	Fly
hemocyte differentiation	GO:0042386	38	0.078	Fly
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.078
positive regulation of growth	GO:0045927	75	0.075
germ line stem cell maintenance	GO:0030718	50	0.075
negative regulation of cell proliferation	GO:0008285	69	0.074
genital disc development	GO:0035215	44	0.073	Fly
eye antennal disc morphogenesis	GO:0007455	34	0.073
regulation of cellular catabolic process	GO:0031329	157	0.072
r3 r4 cell differentiation	GO:0048056	12	0.072
regulation of intracellular signal transduction	GO:1902531	236	0.072
development of primary sexual characteristics	GO:0045137	50	0.071
neuron projection extension	GO:1990138	32	0.071	Fly
ovarian follicle cell development	GO:0030707	248	0.070	Fly
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.070	Mouse
response to organic cyclic compound	GO:0014070	89	0.069
positive regulation of signal transduction	GO:0009967	223	0.068	Mouse
actin cytoskeleton organization	GO:0030036	206	0.068	Fly
regulation of cell proliferation	GO:0042127	163	0.068
negative regulation of rna biosynthetic process	GO:1902679	240	0.068	Fly
polarized epithelial cell differentiation	GO:0030859	10	0.067
dna metabolic process	GO:0006259	227	0.066	Fly
regulation of mitotic cell cycle	GO:0007346	190	0.066
regulation of syncytium formation by plasma membrane fusion	GO:0060142	6	0.063
morphogenesis of follicular epithelium	GO:0016333	36	0.063
salivary gland development	GO:0007431	162	0.062
muscle cell differentiation	GO:0042692	103	0.061
positive regulation of jun kinase activity	GO:0043507	4	0.061
regulation of hemocyte differentiation	GO:0045610	22	0.060	Fly
glial cell migration	GO:0008347	31	0.060
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.059
epithelium migration	GO:0090132	148	0.059
morphogenesis of a branching epithelium	GO:0061138	45	0.058	Mouse Fly
non sensory hair organization	GO:0035316	47	0.057
organic substance catabolic process	GO:1901575	308	0.057
eye antennal disc development	GO:0035214	60	0.056
positive regulation of cellular protein metabolic process	GO:0032270	118	0.056
immune effector process	GO:0002252	98	0.056
axis elongation	GO:0003401	3	0.056
cell growth	GO:0016049	108	0.056	Fly
nucleus localization	GO:0051647	34	0.055
positive regulation of cell migration	GO:0030335	2	0.055
multicellular organism growth	GO:0035264	46	0.055
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.055	Fly
regulation of response to stress	GO:0080134	200	0.054
regulation of stem cell proliferation	GO:0072091	40	0.054	Fly
positive regulation of developmental growth	GO:0048639	62	0.054
myotube differentiation	GO:0014902	46	0.054
regulation of developmental pigmentation	GO:0048070	24	0.054	Fly
programmed cell death	GO:0012501	257	0.053	Mouse Fly
body morphogenesis	GO:0010171	2	0.053
hair cell differentiation	GO:0035315	47	0.051
gonad morphogenesis	GO:0035262	7	0.051
gland morphogenesis	GO:0022612	145	0.051
muscle fiber development	GO:0048747	12	0.050
death	GO:0016265	284	0.050	Mouse Fly
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	24	0.050
gastrulation with mouth forming first	GO:0001703	36	0.049	Fly
neuroblast proliferation	GO:0007405	74	0.049
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.048	Fly
developmental cell growth	GO:0048588	52	0.048	Fly
cellular response to nutrient levels	GO:0031669	62	0.047	Mouse
modification dependent macromolecule catabolic process	GO:0043632	79	0.047
terminal region determination	GO:0007362	25	0.046
small gtpase mediated signal transduction	GO:0007264	88	0.046
regulation of cell size	GO:0008361	63	0.046
nuclear division	GO:0000280	332	0.046
canonical wnt signaling pathway	GO:0060070	21	0.045	Mouse Fly
brain development	GO:0007420	120	0.045
photoreceptor cell development	GO:0042461	96	0.045
regulation of epithelial cell proliferation	GO:0050678	4	0.044
bmp signaling pathway	GO:0030509	27	0.044
camera type eye morphogenesis	GO:0048593	2	0.043
hindbrain development	GO:0030902	2	0.043
endocytosis	GO:0006897	310	0.043
apoptotic process involved in morphogenesis	GO:0060561	3	0.043
cellular catabolic process	GO:0044248	372	0.043
specification of symmetry	GO:0009799	13	0.042
cell death	GO:0008219	279	0.042	Mouse Fly
stem cell proliferation	GO:0072089	88	0.042	Fly
regulation of phosphorus metabolic process	GO:0051174	210	0.042	Mouse
branching morphogenesis of an epithelial tube	GO:0048754	45	0.042	Mouse Fly
negative regulation of response to stimulus	GO:0048585	258	0.042
jnk cascade	GO:0007254	50	0.041
sex determination	GO:0007530	18	0.041
embryonic organ morphogenesis	GO:0048562	5	0.040	Zebrafish Mouse
neurological system process	GO:0050877	358	0.040	Fly
skin development	GO:0043588	65	0.040
pigmentation	GO:0043473	75	0.039	Fly
establishment of monopolar cell polarity	GO:0061162	15	0.039
regulation of cell cycle process	GO:0010564	181	0.039	Fly
apoptotic process	GO:0006915	159	0.039	Mouse
muscle cell development	GO:0055001	50	0.039
regulation of immune system process	GO:0002682	176	0.038
imaginal disc derived female genitalia development	GO:0007486	6	0.038
dorsal ventral axis specification	GO:0009950	66	0.038
negative regulation of cell development	GO:0010721	62	0.038
cell projection assembly	GO:0030031	94	0.037	Fly
regulation of molecular function	GO:0065009	217	0.037	Mouse
cell migration involved in gastrulation	GO:0042074	9	0.037
genitalia development	GO:0048806	26	0.037	Mouse
single organism cell adhesion	GO:0098602	47	0.037
regulation of cellular ketone metabolic process	GO:0010565	3	0.037
renal system development	GO:0072001	72	0.037	Mouse Fly
development of primary female sexual characteristics	GO:0046545	12	0.037
oocyte differentiation	GO:0009994	145	0.037
oocyte construction	GO:0007308	112	0.036
eye photoreceptor cell development	GO:0042462	81	0.036
embryo development ending in birth or egg hatching	GO:0009792	152	0.036	Zebrafish Mouse Fly
female genitalia development	GO:0030540	6	0.036
signal transduction downstream of smoothened	GO:0007227	5	0.036
positive regulation of neuron differentiation	GO:0045666	26	0.035
compound eye photoreceptor development	GO:0042051	78	0.035
regulation of programmed cell death	GO:0043067	152	0.035	Mouse Fly
single organism cellular localization	GO:1902580	180	0.035
regulation of phosphorylation	GO:0042325	147	0.035	Mouse
respiratory system development	GO:0060541	213	0.034	Fly
periodic partitioning	GO:0007365	29	0.034	Fly
positive regulation of epithelial cell differentiation	GO:0030858	1	0.034
oocyte development	GO:0048599	124	0.034
negative regulation of gene expression	GO:0010629	387	0.034	Mouse Fly
columnar cuboidal epithelial cell development	GO:0002066	249	0.034	Fly
regulation of protein phosphorylation	GO:0001932	64	0.033	Mouse
organelle fission	GO:0048285	340	0.033
eggshell formation	GO:0030703	105	0.033
cuticle pattern formation	GO:0035017	27	0.033	Fly
regulation of apoptotic process	GO:0042981	130	0.033	Mouse
response to endogenous stimulus	GO:0009719	119	0.033
regulation of jnk cascade	GO:0046328	40	0.033
border follicle cell migration	GO:0007298	113	0.033
compound eye retinal cell programmed cell death	GO:0046667	23	0.032	Fly
regulation of tube size open tracheal system	GO:0035151	43	0.032
hemocyte migration	GO:0035099	19	0.032
nephron tubule morphogenesis	GO:0072078	3	0.032	Mouse Fly
neuroblast fate commitment	GO:0014017	19	0.032
regulation of cell morphogenesis	GO:0022604	163	0.032	Mouse Fly
long term memory	GO:0007616	62	0.032	Fly
wing disc pattern formation	GO:0035222	66	0.032
gastrulation involving germ band extension	GO:0010004	36	0.032	Fly
neuroblast differentiation	GO:0014016	29	0.031	Fly
negative regulation of cell cycle	GO:0045786	116	0.031	Fly
negative regulation of programmed cell death	GO:0043069	72	0.031	Mouse
regulation of cell death	GO:0010941	173	0.031	Mouse Fly
positive regulation of signaling	GO:0023056	243	0.031	Mouse
stem cell division	GO:0017145	69	0.031
gonad development	GO:0008406	50	0.031
mitotic nuclear division	GO:0007067	213	0.031
male sex differentiation	GO:0046661	25	0.031	Mouse
maintenance of protein location in cell	GO:0032507	26	0.030
cellular response to lipid	GO:0071396	20	0.030
cell junction assembly	GO:0034329	42	0.030
regulation of myotube differentiation	GO:0010830	6	0.030
larval development	GO:0002164	104	0.030	Fly
negative regulation of cellular component organization	GO:0051129	108	0.030
mesoderm development	GO:0007498	78	0.029	Fly
developmental maturation	GO:0021700	172	0.029
cellular protein modification process	GO:0006464	438	0.029	Mouse
determination of digestive tract left right asymmetry	GO:0071907	6	0.029
organ induction	GO:0001759	3	0.029	Fly
positive regulation of axon extension	GO:0045773	2	0.029
non canonical wnt signaling pathway	GO:0035567	8	0.029
establishment of epithelial cell polarity	GO:0090162	13	0.029
single organism intracellular transport	GO:1902582	207	0.029
regulation of bmp signaling pathway	GO:0030510	23	0.028
negative regulation of phosphate metabolic process	GO:0045936	45	0.028
positive regulation of intracellular signal transduction	GO:1902533	116	0.028
cellular macromolecule catabolic process	GO:0044265	136	0.028
regulation of gene expression epigenetic	GO:0040029	128	0.028
regulation of tube length open tracheal system	GO:0035159	24	0.028
response to ecdysone	GO:0035075	34	0.028
eggshell chorion assembly	GO:0007306	66	0.028
r3 r4 cell fate commitment	GO:0007464	10	0.028
cognition	GO:0050890	141	0.028	Fly
imaginal disc pattern formation	GO:0007447	91	0.028	Fly
mapk cascade	GO:0000165	107	0.028
regulation of protein kinase activity	GO:0045859	51	0.027
regulation of cellular component size	GO:0032535	98	0.027
formation of primary germ layer	GO:0001704	24	0.027
head involution	GO:0008258	35	0.027
regulation of smoothened signaling pathway	GO:0008589	28	0.027	Mouse
macromolecule catabolic process	GO:0009057	161	0.027
actin filament based process	GO:0030029	220	0.027	Fly
immune response	GO:0006955	246	0.027
response to lipid	GO:0033993	38	0.026
regulation of localization	GO:0032879	275	0.026
limb development	GO:0060173	1	0.026	Mouse
regulation of canonical wnt signaling pathway	GO:0060828	15	0.026
regulation of cellular amine metabolic process	GO:0033238	3	0.026
determination of bilateral symmetry	GO:0009855	13	0.025
neuron recognition	GO:0008038	101	0.025
exocrine system development	GO:0035272	162	0.025
single organism biosynthetic process	GO:0044711	206	0.025	Fly
striated muscle cell development	GO:0055002	50	0.025
cellular amino acid metabolic process	GO:0006520	61	0.025
cellular response to external stimulus	GO:0071496	66	0.025	Mouse
imaginal disc growth	GO:0007446	37	0.025
cellular response to biotic stimulus	GO:0071216	4	0.025
aggressive behavior	GO:0002118	63	0.024
ras protein signal transduction	GO:0007265	88	0.024
apoptotic process involved in development	GO:1902742	20	0.024
regulation of catabolic process	GO:0009894	170	0.024
cellular response to chemical stimulus	GO:0070887	199	0.024
hematopoietic or lymphoid organ development	GO:0048534	57	0.024	Fly
equator specification	GO:0045317	4	0.023
actin filament organization	GO:0007015	126	0.023	Fly
regulation of neuroblast proliferation	GO:1902692	34	0.023
maintenance of location	GO:0051235	73	0.023
divalent metal ion transport	GO:0070838	26	0.023
negative regulation of gene expression epigenetic	GO:0045814	77	0.023
phagocytosis	GO:0006909	215	0.023
protein import into nucleus	GO:0006606	51	0.023
g protein coupled receptor signaling pathway	GO:0007186	136	0.023
cell fate specification involved in pattern specification	GO:0060573	8	0.023	Fly
regulation of cell shape	GO:0008360	113	0.023	Fly
zygotic determination of anterior posterior axis embryo	GO:0007354	27	0.023
regulation of erbb signaling pathway	GO:1901184	42	0.022
positive regulation of phosphate metabolic process	GO:0045937	139	0.022
anterior commissure morphogenesis	GO:0021960	2	0.022
protein localization to nucleus	GO:0034504	55	0.022
wing and notum subfield formation	GO:0035309	13	0.022	Fly
head segmentation	GO:0035287	13	0.022
protein modification by small protein conjugation or removal	GO:0070647	106	0.022
leg disc development	GO:0035218	92	0.021
telencephalon development	GO:0021537	2	0.021
amine metabolic process	GO:0009308	12	0.021
developmental growth involved in morphogenesis	GO:0060560	65	0.021	Fly
cell fate commitment involved in formation of primary germ layer	GO:0060795	10	0.021
epidermal cell differentiation	GO:0009913	51	0.021
regulation of response to biotic stimulus	GO:0002831	63	0.021
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.020	Fly
negative regulation of epithelial cell proliferation	GO:0050680	4	0.020
positive regulation of mapk cascade	GO:0043410	63	0.020
open tracheal system development	GO:0007424	204	0.020	Fly
chaeta development	GO:0022416	97	0.020
chaeta morphogenesis	GO:0008407	42	0.020
imaginal disc derived leg morphogenesis	GO:0007480	80	0.020
histone acetylation	GO:0016573	38	0.020
spermatogenesis	GO:0007283	200	0.019
negative regulation of heart induction	GO:1901320	3	0.019	Fly
spinal cord development	GO:0021510	1	0.019
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.019
response to nitrogen compound	GO:1901698	90	0.019
regulation of mapk cascade	GO:0043408	92	0.019
memory	GO:0007613	94	0.019	Fly
camera type eye development	GO:0043010	4	0.019
cellular response to molecule of bacterial origin	GO:0071219	3	0.019
cytokinesis	GO:0000910	90	0.019
ovarian follicle cell migration	GO:0007297	121	0.019
regulation of cellular amino acid metabolic process	GO:0006521	0	0.019
positive regulation of retinal cell programmed cell death	GO:0046670	9	0.019	Fly
dorsal appendage formation	GO:0046843	47	0.019
negative regulation of neuron differentiation	GO:0045665	16	0.018
cytoplasmic transport	GO:0016482	130	0.018
chromatin modification	GO:0016568	147	0.018
central nervous system projection neuron axonogenesis	GO:0021952	6	0.018
proteasomal protein catabolic process	GO:0010498	59	0.018
regulation of compound eye pigmentation	GO:0048076	7	0.018	Fly
anatomical structure homeostasis	GO:0060249	97	0.018
negative regulation of protein metabolic process	GO:0051248	85	0.018	Mouse
embryonic hindgut morphogenesis	GO:0048619	48	0.018	Fly
germ line stem cell division	GO:0042078	25	0.018
regulation of cell fate commitment	GO:0010453	29	0.018	Fly
maintenance of protein location	GO:0045185	28	0.018
cellular ketone metabolic process	GO:0042180	24	0.018
regulation of dendrite morphogenesis	GO:0048814	28	0.018
regulation of jun kinase activity	GO:0043506	8	0.018
regulation of dendrite development	GO:0050773	37	0.018
homeostatic process	GO:0042592	199	0.018
learning	GO:0007612	75	0.018
retina morphogenesis in camera type eye	GO:0060042	2	0.018
determination of left right symmetry	GO:0007368	9	0.018
positive regulation of cell communication	GO:0010647	250	0.018	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	85	0.018	Mouse
establishment of spindle orientation	GO:0051294	18	0.018
dendrite guidance	GO:0070983	21	0.018
cellular homeostasis	GO:0019725	80	0.017
regulation of mitosis	GO:0007088	56	0.017
regulation of muscle cell differentiation	GO:0051147	8	0.017
camera type eye photoreceptor cell differentiation	GO:0060219	2	0.017

Wnt4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.045
organ system cancer	DOID:0050686	0.045
disease of cellular proliferation	DOID:14566	0.045

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