Drosophila melanogaster

45 known processes

Pros26.4 (Dmel_CG5289)

Proteasome 26S subunit subunit 4 ATPase

(Aliases: 5289,CG5289,Dm_Rpt2,Rpt2,Dm-S4-1,dRpt2,S4,p54,DmP26S4,P26s4,p56,Dmel\CG5289,pros26.4)

Pros26.4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
proteolysisGO:00065081920.976
cellular response to dna damage stimulusGO:00069742230.969
protein dna complex assemblyGO:0065004630.894
modification dependent macromolecule catabolic processGO:0043632790.889
dna templated transcriptional preinitiation complex assemblyGO:0070897200.863
rna polymerase ii transcriptional preinitiation complex assemblyGO:0051123200.841
cellular catabolic processGO:00442483720.817
protein complex biogenesisGO:00702712010.785
dna templated transcription initiationGO:0006352250.783
proteasome assemblyGO:004324820.743
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.735
positive regulation of macromolecule metabolic processGO:00106044050.732
protein catabolic processGO:00301631010.681
Worm
proteasomal protein catabolic processGO:0010498590.670
cellular protein catabolic processGO:0044257830.668
protein dna complex subunit organizationGO:0071824860.663
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434370.663
ubiquitin dependent protein catabolic processGO:0006511780.661
catabolic processGO:00090564090.633
Worm
spindle elongationGO:0051231830.620
agingGO:00075681430.601
Worm
macromolecular complex assemblyGO:00650032560.599
organelle fissionGO:00482853400.598
positive regulation of biosynthetic processGO:00098913160.595
modification dependent protein catabolic processGO:0019941780.586
nuclear divisionGO:00002803320.585
spindle organizationGO:00070512530.573
positive regulation of cellular biosynthetic processGO:00313283160.564
transcription from rna polymerase ii promoterGO:00063663680.541
male gamete generationGO:00482322010.530
proteolysis involved in cellular protein catabolic processGO:0051603830.526
cellular macromolecule catabolic processGO:00442651360.480
macromolecule catabolic processGO:00090571610.478
Worm
positive regulation of nucleic acid templated transcriptionGO:19035082660.389
positive regulation of nucleobase containing compound metabolic processGO:00459353320.386
determination of adult lifespanGO:00083401370.386
Worm
regulation of transcription from rna polymerase ii promoterGO:00063573780.373
positive regulation of peptidase activityGO:0010952290.369
mitotic spindle organizationGO:00070522200.364
transcription initiation from rna polymerase ii promoterGO:0006367250.342
spermatogenesisGO:00072832000.338
mitotic spindle elongationGO:0000022810.336
positive regulation of macromolecule biosynthetic processGO:00105572830.323
cell proliferationGO:00082832990.297
positive regulation of protein complex assemblyGO:0031334220.297
positive regulation of rna metabolic processGO:00512542710.278
positive regulation of rna biosynthetic processGO:19026802660.268
positive regulation of proteolysisGO:0045862520.258
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.257
protein complex assemblyGO:00064612000.245
organic substance catabolic processGO:19015753080.229
Worm
regulation of rna polymerase ii transcriptional preinitiation complex assemblyGO:004589810.226
positive regulation of transcription dna templatedGO:00458932660.219
multicellular organismal agingGO:00102591400.202
Worm
positive regulation of gene expressionGO:00106282900.201
mitotic nuclear divisionGO:00070672130.191
er associated ubiquitin dependent protein catabolic processGO:003043330.177
apoptotic processGO:00069151590.173
positive regulation of cellular component biogenesisGO:0044089800.163
spindle assembly involved in mitosisGO:0090307500.160
cellular protein complex assemblyGO:0043623710.159
response to organic substanceGO:00100332840.157
regulation of cellular component biogenesisGO:00440872010.155
cell deathGO:00082192790.141
regulation of endopeptidase activityGO:0052548360.139
deathGO:00162652840.137
larval developmentGO:00021641040.131
regulation of cellular protein metabolic processGO:00322682430.128
positive regulation of endopeptidase activityGO:0010950260.125
dna repairGO:0006281540.122
positive regulation of protein metabolic processGO:00512471280.118
positive regulation of cellular protein metabolic processGO:00322701180.116
microtubule cytoskeleton organization involved in mitosisGO:1902850520.105
dna metabolic processGO:00062592270.104
negative regulation of gene expressionGO:00106293870.103
regulation of proteolysisGO:0030162870.102
positive regulation of nitrogen compound metabolic processGO:00511733540.097
cellular macromolecular complex assemblyGO:00346221530.092
regulation of peptidase activityGO:0052547390.089
peroxisome organizationGO:0007031140.084
negative regulation of cellular metabolic processGO:00313243820.080
regulation of catabolic processGO:00098941700.077
spindle assemblyGO:0051225800.076
positive regulation of proteasomal protein catabolic processGO:1901800200.074
embryo development ending in birth or egg hatchingGO:00097921520.073
Worm
programmed cell deathGO:00125012570.073
atp metabolic processGO:0046034490.071
nucleoside monophosphate metabolic processGO:0009123520.070
purine nucleoside monophosphate metabolic processGO:0009126500.069
dna templated transcription elongationGO:0006354180.069
chromatin organizationGO:00063252070.066
body morphogenesisGO:001017120.066
regulation of proteasomal protein catabolic processGO:0061136390.063
positive regulation of cellular component organizationGO:00511301560.061
regulation of cell differentiationGO:00455953020.060
regulation of protein complex assemblyGO:0043254420.060
regulation of gene expression epigeneticGO:00400291280.059
ribonucleoside monophosphate catabolic processGO:0009158390.055
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.055
regulation of locomotionGO:0040012420.054
aromatic compound catabolic processGO:00194391660.053
protein modification by small protein conjugation or removalGO:00706471060.051
purine ribonucleoside monophosphate metabolic processGO:0009167500.050
mitotic cell cycle phase transitionGO:00447721380.050
ribonucleoside monophosphate metabolic processGO:0009161510.050
regulation of cellular ketone metabolic processGO:001056530.049
male meiosisGO:0007140520.049
regulation of cell cycleGO:00517262910.049
single organism catabolic processGO:00447122280.048
intracellular signal transductionGO:00355563000.048
establishment of localization in cellGO:00516494020.048
Worm
neurological system processGO:00508773580.048
camera type eye developmentGO:004301040.047
negative regulation of signal transductionGO:00099682060.044
spermatid differentiationGO:00485151140.043
response to endogenous stimulusGO:00097191190.042
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436190.041
autophagyGO:00069141080.041
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052240.041
epithelial cell differentiationGO:00308553220.041
regulation of protein metabolic processGO:00512462560.040
regulation of multicellular organismal developmentGO:20000264140.039
negative regulation of biosynthetic processGO:00098902770.039
chemotaxisGO:00069352490.039
negative regulation of sequence specific dna binding transcription factor activityGO:004343340.037
chromosome organizationGO:00512763600.036
negative regulation of cellular biosynthetic processGO:00313272770.036
nucleotide excision repairGO:000628980.035
positive regulation of catabolic processGO:00098961050.035
cellular protein modification processGO:00064644380.035
vesicle mediated transportGO:00161923810.035
negative regulation of nucleic acid templated transcriptionGO:19035072400.034
negative regulation of rna biosynthetic processGO:19026792400.034
molting cycleGO:0042303560.034
protein ubiquitinationGO:0016567700.034
carbohydrate derivative catabolic processGO:19011361180.032
meiotic cell cycleGO:00513211710.031
anterior posterior axis specification embryoGO:00085951030.031
growthGO:00400073590.030
cell migrationGO:00164772380.030
appendage developmentGO:00487364010.030
transmembrane transportGO:00550851390.030
chromatin remodelingGO:0006338720.030
cell cycle phase transitionGO:00447701400.029
taxisGO:00423303040.029
regulation of mitotic cell cycleGO:00073461900.029
organonitrogen compound catabolic processGO:19015651280.028
posttranscriptional regulation of gene expressionGO:00106081450.028
organic cyclic compound catabolic processGO:19013611680.028
nucleoside metabolic processGO:00091161270.027
sister chromatid segregationGO:0000819920.027
synaptic transmissionGO:00072682880.027
regulation of transportGO:00510491810.027
gene silencingGO:00164581380.027
ribonucleotide metabolic processGO:00092591450.027
cell motilityGO:00488702510.027
meiotic cell cycle processGO:19030461320.026
appendage morphogenesisGO:00351073970.026
regulation of catalytic activityGO:00507901850.026
regulation of molecular functionGO:00650092170.026
lipid metabolic processGO:00066291210.026
chromosome separationGO:0051304420.026
positive regulation of molecular functionGO:00440931360.026
ribose phosphate metabolic processGO:00196931450.026
regulation of mitosisGO:0007088560.026
negative regulation of signalingGO:00230572190.025
purine ribonucleoside monophosphate catabolic processGO:0009169380.025
chromosome segregationGO:00070591570.025
endomembrane system organizationGO:00102561190.025
response to metal ionGO:0010038230.024
regulation of hydrolase activityGO:0051336970.024
transcription elongation from rna polymerase ii promoterGO:0006368180.024
cellular response to organic substanceGO:00713101320.024
purine nucleoside monophosphate catabolic processGO:0009128380.024
regulation of apoptotic processGO:00429811300.024
lipid modificationGO:0030258240.024
regulation of protein modification processGO:00313991120.024
negative regulation of cell communicationGO:00106482230.023
heterocycle catabolic processGO:00467001660.023
homeostatic processGO:00425921990.023
embryonic morphogenesisGO:00485982060.023
response to abiotic stimulusGO:00096283410.022
meiotic nuclear divisionGO:00071261510.022
regulation of programmed cell deathGO:00430671520.022
purine ribonucleotide metabolic processGO:00091501450.022
negative regulation of transcription dna templatedGO:00458922370.021
rna catabolic processGO:0006401370.021
nucleoside monophosphate catabolic processGO:0009125390.021
organonitrogen compound metabolic processGO:19015643180.020
purine nucleoside triphosphate metabolic processGO:00091441190.020
protein modification by small protein conjugationGO:0032446790.020
small molecule metabolic processGO:00442813050.020
regulation of dna templated transcription elongationGO:0032784170.020
ion transmembrane transportGO:00342201220.020
negative regulation of multicellular organismal processGO:00512411420.020
regulation of cell cycle processGO:00105641810.019
cellular nitrogen compound catabolic processGO:00442701650.019
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919160.019
regulation of cellular catabolic processGO:00313291570.019
regulation of nuclear divisionGO:0051783580.019
purine containing compound metabolic processGO:00725211550.019
wing disc morphogenesisGO:00074723440.019
oxoacid metabolic processGO:00434361030.019
membrane organizationGO:00610241120.019
purine nucleoside catabolic processGO:00061521120.019
regulation of intracellular signal transductionGO:19025312360.019
mitotic sister chromatid segregationGO:0000070870.019
cellular ketone metabolic processGO:0042180240.019
mapk cascadeGO:00001651070.019
columnar cuboidal epithelial cell differentiationGO:00020652560.019
protein localizationGO:00081042840.019
Worm
phosphorylationGO:00163102940.019
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.019
imaginal disc derived appendage morphogenesisGO:00351143950.018
cell divisionGO:00513012480.018
negative regulation of developmental processGO:00510932010.018
cell maturationGO:00484691440.018
purine ribonucleotide catabolic processGO:00091541090.018
protein modification processGO:00362114380.018
regulation of growthGO:00400082330.018
positive regulation of catalytic activityGO:00430851180.018
fatty acid metabolic processGO:0006631200.018
cell adhesionGO:00071551360.018
cellular homeostasisGO:0019725800.018
protein deubiquitinationGO:0016579170.018
organophosphate catabolic processGO:00464341120.018
purine ribonucleoside triphosphate catabolic processGO:00092071080.018
gene silencing by rnaGO:0031047570.018
forebrain developmentGO:003090020.018
developmental maturationGO:00217001720.018
negative regulation of macromolecule biosynthetic processGO:00105582700.018
intracellular transportGO:00469072280.017
regulation of cell developmentGO:00602842150.017
cellular response to chemical stimulusGO:00708871990.017
purine ribonucleoside triphosphate metabolic processGO:00092051190.017
response to radiationGO:00093141550.016
ovarian follicle cell developmentGO:00307072480.016
regulation of phosphate metabolic processGO:00192202100.016
regionalizationGO:00030024160.016
nucleobase containing small molecule metabolic processGO:00550861740.016
eye developmentGO:00016543230.016
ribonucleoside triphosphate metabolic processGO:00091991190.015
positive regulation of cell communicationGO:00106472500.015
nucleus organizationGO:0006997450.015
imaginal disc derived wing morphogenesisGO:00074763370.015
centrosome organizationGO:00512971630.015
carboxylic acid metabolic processGO:0019752920.015
nucleoside phosphate metabolic processGO:00067531620.015
positive regulation of response to stimulusGO:00485843230.014
ribonucleoside catabolic processGO:00424541120.014
negative regulation of nitrogen compound metabolic processGO:00511722650.014
positive regulation of cellular catabolic processGO:0031331950.014
intracellular mrna localizationGO:0008298660.014
nucleoside triphosphate metabolic processGO:00091411200.014
enzyme linked receptor protein signaling pathwayGO:00071671790.014
single organism behaviorGO:00447083910.014
nucleobase containing compound catabolic processGO:00346551650.014
regulation of cellular protein catabolic processGO:1903362440.014
rna interferenceGO:0016246270.014
purine nucleotide metabolic processGO:00061631460.014
gonad developmentGO:0008406500.013
regulation of cell divisionGO:0051302720.013
cell recognitionGO:00080371020.013
response to hexoseGO:000974630.013
response to oxygen containing compoundGO:19017002000.013
atp catabolic processGO:0006200380.013
imaginal disc derived wing vein specificationGO:0007474480.013
nucleoside triphosphate catabolic processGO:00091431080.013
positive regulation of cell deathGO:0010942690.013
regulation of phosphorus metabolic processGO:00511742100.013
purine ribonucleoside catabolic processGO:00461301120.013
nucleotide catabolic processGO:00091661090.013
regulation of protein modification by small protein conjugation or removalGO:1903320250.012
posttranscriptional gene silencing by rnaGO:0035194450.012
response to organonitrogen compoundGO:0010243750.012
negative regulation of cellular component organizationGO:00511291080.012
regulation of protein catabolic processGO:0042176550.012
response to organic cyclic compoundGO:0014070890.012
organic acid metabolic processGO:00060821030.012
response to woundingGO:0009611940.012
ribonucleoside metabolic processGO:00091191270.012
regulation of cellular amine metabolic processGO:003323830.012
single organism cellular localizationGO:19025801800.012
regulation of meiosisGO:004002030.012
regulation of organelle organizationGO:00330431960.012
positive regulation of signalingGO:00230562430.012
cellular macromolecule localizationGO:00707272200.012
protein neddylationGO:004511650.011
protein processingGO:0016485680.011
tube developmentGO:00352952440.011
glycosyl compound catabolic processGO:19016581120.011
development of primary sexual characteristicsGO:0045137500.011
endocytosisGO:00068973100.011
nucleoside phosphate catabolic processGO:19012921100.011
embryonic axis specificationGO:00005781070.011
regulation of reproductive processGO:2000241540.011
organophosphate metabolic processGO:00196371950.011
sensory perceptionGO:00076001960.011
positive regulation of protein catabolic processGO:0045732340.011
regulation of cell deathGO:00109411730.011
positive regulation of phosphate metabolic processGO:00459371390.011
mitotic sister chromatid separationGO:0051306300.011
negative regulation of cellular protein metabolic processGO:0032269850.011
regulation of nervous system developmentGO:00519602480.011
regulation of anatomical structure sizeGO:00900661630.011
cellular lipid metabolic processGO:0044255830.011
single organism intracellular transportGO:19025822070.011
ion transportGO:00068111450.010
ribonucleotide catabolic processGO:00092611090.010
localization of cellGO:00516742570.010
protein destabilizationGO:003164820.010
wound healingGO:0042060750.010
epithelial cell developmentGO:00020642740.010
posttranscriptional gene silencingGO:0016441460.010

Pros26.4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.043
nervous system diseaseDOID:86300.018