Drosophila melanogaster

73 known processes

RnrL (Dmel_CG5371)

Ribonucleoside diphosphate reductase large subunit

(Aliases: CG5371,l(2)k06709,Dmel\CG5371,DmRNR1,RNR1,RntL,RnrM1)

RnrL biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
double strand break repair via homologous recombinationGO:0000724130.622
nuclear dna replicationGO:003326010.530
dna repairGO:0006281540.526
double strand break repairGO:0006302260.476
cellular response to dna damage stimulusGO:00069742230.407
single organism biosynthetic processGO:00447112060.353
protein dna complex assemblyGO:0065004630.337
positive regulation of endopeptidase activityGO:0010950260.327
dna metabolic processGO:00062592270.317
nucleotide excision repairGO:000628980.309
homeostatic processGO:00425921990.239
double strand break repair via nonhomologous end joiningGO:000630350.227
dna recombinationGO:0006310320.219
regulation of cell cycle phase transitionGO:19019871300.217
dna damage checkpointGO:0000077780.207
mitotic dna damage checkpointGO:0044773740.198
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.185
positive regulation of hydrolase activityGO:0051345780.173
cell cycle checkpointGO:0000075950.170
regulation of cell cycle processGO:00105641810.162
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280230.144
protein importGO:0017038550.142
cell cycle dna replicationGO:0044786230.125
g2 dna damage checkpointGO:0031572690.115
cell proliferationGO:00082832990.114
eye developmentGO:00016543230.107
regulation of cell cycleGO:00517262910.106
regulation of endopeptidase activityGO:0052548360.105
dna endoreduplicationGO:0042023220.102
negative regulation of cell cycle phase transitionGO:19019881030.102
regulation of mitotic cell cycleGO:00073461900.097
agingGO:00075681430.095
mitotic cell cycle phase transitionGO:00447721380.094
dna integrity checkpointGO:0031570810.094
camera type eye morphogenesisGO:004859320.087
regulation of cytoskeleton organizationGO:0051493890.087
positive regulation of cysteine type endopeptidase activityGO:2001056240.087
body morphogenesisGO:001017120.087
negative regulation of biosynthetic processGO:00098902770.083
cell divisionGO:00513012480.080
protein complex assemblyGO:00064612000.075
response to light stimulusGO:00094161240.071
positive regulation of peptidase activityGO:0010952290.070
enzyme linked receptor protein signaling pathwayGO:00071671790.069
nucleobase containing small molecule metabolic processGO:00550861740.069
regulation of catabolic processGO:00098941700.069
immune responseGO:00069552460.069
mitotic dna integrity checkpointGO:0044774750.067
cell cycle phase transitionGO:00447701400.067
single organism intracellular transportGO:19025822070.065
compound eye developmentGO:00487493070.064
single organism behaviorGO:00447083910.063
cellular protein complex disassemblyGO:0043624350.062
positive regulation of nitrogen compound metabolic processGO:00511733540.062
dna replicationGO:0006260480.061
negative regulation of cellular biosynthetic processGO:00313272770.061
negative regulation of cell cycleGO:00457861160.060
cellular component disassemblyGO:0022411460.060
positive regulation of proteolysisGO:0045862520.058
heterocycle catabolic processGO:00467001660.057
mitotic cell cycle checkpointGO:0007093880.057
single organism cellular localizationGO:19025801800.056
zymogen activationGO:0031638200.055
establishment of protein localization to organelleGO:0072594620.055
small molecule metabolic processGO:00442813050.055
anatomical structure homeostasisGO:0060249970.054
negative regulation of nucleic acid templated transcriptionGO:19035072400.054
single organism nuclear importGO:1902593510.053
response to abiotic stimulusGO:00096283410.053
cellular macromolecule localizationGO:00707272200.053
organic cyclic compound catabolic processGO:19013611680.053
proteolysisGO:00065081920.052
positive regulation of cellular component organizationGO:00511301560.051
response to woundingGO:0009611940.051
negative regulation of cell cycle processGO:00109481090.051
negative regulation of transcription dna templatedGO:00458922370.051
mitotic spindle organizationGO:00070522200.051
translesion synthesisGO:001998520.050
nucleosome assemblyGO:0006334350.050
regulation of catalytic activityGO:00507901850.048
negative regulation of rna biosynthetic processGO:19026792400.048
positive regulation of protein metabolic processGO:00512471280.048
organophosphate metabolic processGO:00196371950.048
determination of adult lifespanGO:00083401370.047
immune system processGO:00023763470.046
macromolecule catabolic processGO:00090571610.046
cellular protein modification processGO:00064644380.045
camera type eye developmentGO:004301040.045
female meiotic divisionGO:0007143700.045
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919160.045
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630110.044
macromolecular complex disassemblyGO:0032984370.043
macromolecular complex assemblyGO:00650032560.043
regulation of molecular functionGO:00650092170.043
eye morphogenesisGO:00485922600.043
multicellular organism growthGO:0035264460.043
negative regulation of nitrogen compound metabolic processGO:00511722650.042
gonad developmentGO:0008406500.042
response to external biotic stimulusGO:00432072930.042
spermatogenesisGO:00072832000.042
regulation of cellular catabolic processGO:00313291570.042
meiotic cell cycle processGO:19030461320.041
meiotic cell cycleGO:00513211710.041
dna dependent dna replicationGO:0006261170.041
intracellular transportGO:00469072280.041
nucleoside phosphate metabolic processGO:00067531620.040
regulation of mitotic cell cycle phase transitionGO:19019901300.040
positive regulation of catalytic activityGO:00430851180.040
deathGO:00162652840.040
regulation of notch signaling pathwayGO:00085931000.040
response to other organismGO:00517072930.039
regulation of hydrolase activityGO:0051336970.039
organic substance catabolic processGO:19015753080.039
regulation of protein complex assemblyGO:0043254420.039
negative regulation of nucleobase containing compound metabolic processGO:00459342610.039
dna double strand break processingGO:000072930.038
positive regulation of molecular functionGO:00440931360.038
spindle organizationGO:00070512530.038
regulation of multicellular organismal developmentGO:20000264140.038
regulation of cellular component biogenesisGO:00440872010.037
cellular catabolic processGO:00442483720.037
notch signaling pathwayGO:00072191200.037
head developmentGO:00603221350.036
protein targetingGO:0006605640.036
multicellular organismal agingGO:00102591400.036
nucleotide metabolic processGO:00091171610.035
cellular nitrogen compound catabolic processGO:00442701650.035
actin cytoskeleton organizationGO:00300362060.035
dna replication initiationGO:000627060.034
larval developmentGO:00021641040.034
male gamete generationGO:00482322010.034
actin filament based processGO:00300292200.033
carbohydrate derivative metabolic processGO:19011352170.033
nucleotide biosynthetic processGO:0009165340.033
positive regulation of cell proliferationGO:0008284470.033
negative regulation of rna metabolic processGO:00512532510.033
tube developmentGO:00352952440.033
intracellular protein transportGO:00068861040.033
single organism catabolic processGO:00447122280.033
sex differentiationGO:0007548810.032
g1 s transition of mitotic cell cycleGO:0000082310.032
programmed cell deathGO:00125012570.032
protein targeting to nucleusGO:0044744510.032
nucleobase containing compound catabolic processGO:00346551650.032
embryonic morphogenesisGO:00485982060.031
cellular amine metabolic processGO:0044106120.031
negative regulation of gene expressionGO:00106293870.030
ribonucleoside metabolic processGO:00091191270.030
axonogenesisGO:00074092900.030
reproductive structure developmentGO:0048608740.029
activation of cysteine type endopeptidase activityGO:0097202170.029
multi organism reproductive behaviorGO:00447051210.029
postreplication repairGO:000630120.029
glycosyl compound metabolic processGO:19016571270.029
response to biotic stimulusGO:00096072940.029
cell motilityGO:00488702510.028
respiratory system developmentGO:00605412130.028
protein complex disassemblyGO:0043241360.028
response to organic substanceGO:00100332840.028
positive regulation of catabolic processGO:00098961050.027
meiotic chromosome segregationGO:0045132590.027
negative regulation of molecular functionGO:0044092510.027
cell deathGO:00082192790.027
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281250.027
cell migrationGO:00164772380.027
antimicrobial humoral responseGO:0019730990.027
intracellular signal transductionGO:00355563000.026
production of molecular mediator of immune responseGO:0002440460.026
cell cycle g1 s phase transitionGO:0044843310.026
regulation of developmental growthGO:00486381740.026
eggshell formationGO:00307031050.026
positive regulation of nucleobase containing compound metabolic processGO:00459353320.026
regulation of proteolysisGO:0030162870.026
negative regulation of mitotic cell cycle phase transitionGO:19019911030.025
telomere organizationGO:0032200210.025
organonitrogen compound metabolic processGO:19015643180.025
cell agingGO:000756920.025
dna conformation changeGO:00711031050.025
ion transportGO:00068111450.025
protein transportGO:00150311550.025
cell fate specificationGO:0001708710.025
carbohydrate derivative catabolic processGO:19011361180.024
chromosome segregationGO:00070591570.024
recombinational repairGO:0000725130.024
catabolic processGO:00090564090.024
ribose phosphate metabolic processGO:00196931450.024
mitotic g2 m transition checkpointGO:0044818700.024
development of primary sexual characteristicsGO:0045137500.024
response to inorganic substanceGO:0010035440.023
regulation of cellular ketone metabolic processGO:001056530.023
positive regulation of macromolecule metabolic processGO:00106044050.023
aromatic compound catabolic processGO:00194391660.023
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.023
signal transduction in response to dna damageGO:004277030.023
positive regulation of cellular catabolic processGO:0031331950.023
ribonucleotide metabolic processGO:00092591450.022
regulation of gene expression epigeneticGO:00400291280.022
multi organism behaviorGO:00517051750.022
regulation of cell morphogenesisGO:00226041630.022
actin filament organizationGO:00070151260.022
regulation of localizationGO:00328792750.022
regulation of peptidase activityGO:0052547390.021
carboxylic acid metabolic processGO:0019752920.021
regulation of nervous system developmentGO:00519602480.021
nucleoside phosphate biosynthetic processGO:1901293340.021
response to lipopolysaccharideGO:003249640.021
regulation of organelle organizationGO:00330431960.021
meiotic nuclear divisionGO:00071261510.021
protein localizationGO:00081042840.021
organonitrogen compound biosynthetic processGO:19015661170.021
cellular macromolecular complex assemblyGO:00346221530.020
regionalizationGO:00030024160.020
organic substance transportGO:00717022570.020
cellular response to organic substanceGO:00713101320.020
regulation of cell differentiationGO:00455953020.020
positive regulation of protein complex assemblyGO:0031334220.020
purine nucleotide metabolic processGO:00061631460.020
gene silencingGO:00164581380.020
response to endogenous stimulusGO:00097191190.019
ribonucleotide catabolic processGO:00092611090.019
regulation of cell cycle g1 s phase transitionGO:1902806230.019
developmental growthGO:00485892800.019
connective tissue developmentGO:006144830.019
positive regulation of cellular amino acid metabolic processGO:004576400.019
negative regulation of mitotic cell cycleGO:00459301090.019
tissue morphogenesisGO:00487292970.019
protein modification processGO:00362114380.019
maintenance of location in cellGO:0051651280.019
non recombinational repairGO:000072670.019
protein localization to organelleGO:0033365820.018
telomere maintenanceGO:0000723210.018
establishment of protein localizationGO:00451841630.018
regulation of programmed cell deathGO:00430671520.018
nuclear importGO:0051170510.018
positive regulation of nucleotide metabolic processGO:0045981550.018
dna duplex unwindingGO:0032508160.018
appendage developmentGO:00487364010.018
retina development in camera type eyeGO:006004140.018
nuclear divisionGO:00002803320.018
dna geometric changeGO:0032392160.018
purine ribonucleotide metabolic processGO:00091501450.018
positive regulation of phosphorus metabolic processGO:00105621390.018
purine containing compound catabolic processGO:00725231120.018
dorsal ventral pattern formationGO:00099531330.017
negative regulation of macromolecule biosynthetic processGO:00105582700.017
brain developmentGO:00074201200.017
positive regulation of developmental processGO:00510941430.017
embryo development ending in birth or egg hatchingGO:00097921520.017
response to ionizing radiationGO:0010212320.017
locomotory behaviorGO:00076261760.017
regulation of cell proliferationGO:00421271630.017
protein maturationGO:0051604710.017
reproductive system developmentGO:0061458740.017
chorion containing eggshell formationGO:00073041050.017
purine containing compound metabolic processGO:00725211550.017
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.017
negative regulation of cell cycle g1 s phase transitionGO:1902807130.017
chemosensory behaviorGO:00076351060.017
positive regulation of cellular component biogenesisGO:0044089800.016
positive regulation of protein transportGO:0051222370.016
positive regulation of multicellular organismal processGO:00512401430.016
chromosome organizationGO:00512763600.016
dna packagingGO:0006323910.016
cellular macromolecule catabolic processGO:00442651360.016
regulation of phosphorus metabolic processGO:00511742100.016
cell recognitionGO:00080371020.016
nucleocytoplasmic transportGO:0006913720.016
regulation of cellular amine metabolic processGO:003323830.016
kidney developmentGO:000182230.016
organelle assemblyGO:00709251980.016
positive regulation of cellular amine metabolic processGO:003324000.016
regulation of dna replicationGO:0006275130.016
humoral immune responseGO:00069591170.016
positive regulation of cellular protein metabolic processGO:00322701180.016
cellular component assembly involved in morphogenesisGO:00109271510.016
positive regulation of phosphate metabolic processGO:00459371390.015
regulation of g1 s transition of mitotic cell cycleGO:2000045230.015
compound eye morphogenesisGO:00017452490.015
immune effector processGO:0002252980.015
amine metabolic processGO:0009308120.015
defense responseGO:00069523000.015
positive regulation of signalingGO:00230562430.015
vesicle mediated transportGO:00161923810.015
mitotic g2 dna damage checkpointGO:0007095690.015
wound healingGO:0042060750.015
reproductive behaviorGO:00190981220.015
phagocytosisGO:00069092150.015
regulation of transcription factor import into nucleusGO:0042990220.015
endocytosisGO:00068973100.015
positive regulation of cellular biosynthetic processGO:00313283160.015
stem cell differentiationGO:00488631170.015
chromatin remodelingGO:0006338720.015
positive regulation of programmed cell deathGO:0043068620.015
purine ribonucleoside metabolic processGO:00461281270.015
purine nucleoside catabolic processGO:00061521120.014
smad protein import into nucleusGO:0007184110.014
nuclear transportGO:0051169720.014
nucleoside triphosphate catabolic processGO:00091431080.014
cellular protein localizationGO:00346131600.014
maintenance of protein locationGO:0045185280.014
renal system developmentGO:0072001720.014
cellular response to chemical stimulusGO:00708871990.014
regulation of production of molecular mediator of immune responseGO:0002700440.014
growthGO:00400073590.014
defense response to other organismGO:00985422250.014
urogenital system developmentGO:0001655720.014
response to growth factorGO:0070848310.014
compound eye photoreceptor cell differentiationGO:00017511400.014
taxisGO:00423303040.014
regulation of cellular response to stressGO:0080135890.014
purine ribonucleoside triphosphate metabolic processGO:00092051190.014
central nervous system developmentGO:00074172010.014
mitotic chromosome condensationGO:0007076220.014
purine nucleoside triphosphate metabolic processGO:00091441190.013
embryonic development via the syncytial blastodermGO:00017001480.013
maintenance of protein location in cellGO:0032507260.013
morphogenesis of an epitheliumGO:00020092760.013
purine nucleotide catabolic processGO:00061951090.013
dna amplificationGO:0006277110.013
oxoacid metabolic processGO:00434361030.013
regulation of nucleotide metabolic processGO:0006140620.013
resolution of meiotic recombination intermediatesGO:000071260.013
positive regulation of protein import into nucleusGO:0042307210.013
ribonucleoside catabolic processGO:00424541120.013
cellular protein catabolic processGO:0044257830.013
positive regulation of signal transductionGO:00099672230.013
transcription from rna polymerase ii promoterGO:00063663680.013
establishment of localization in cellGO:00516494020.013
positive regulation of cell migrationGO:003033520.013
protein phosphorylationGO:00064681690.013
regulation of response to external stimulusGO:00321011150.013
lateral inhibitionGO:00463312060.012
centrosome cycleGO:00070981370.012
organophosphate catabolic processGO:00464341120.012
purine ribonucleotide catabolic processGO:00091541090.012
hematopoietic progenitor cell differentiationGO:000224410.012
positive regulation of protein localization to nucleusGO:1900182210.012
gtp catabolic processGO:0006184720.012
protein localization to nucleusGO:0034504550.012
cell cell signaling involved in cell fate commitmentGO:00451682100.012
imaginal disc derived appendage developmentGO:00487373990.012
gland developmentGO:00487321910.012
ribonucleoside triphosphate metabolic processGO:00091991190.012
regulation of purine nucleotide catabolic processGO:0033121480.012
negative regulation of cell deathGO:0060548810.012
positive regulation of nucleic acid templated transcriptionGO:19035082660.012
positive regulation of histone deacetylationGO:003106520.012
negative regulation of cellular metabolic processGO:00313243820.012
negative regulation of programmed cell deathGO:0043069720.012
open tracheal system developmentGO:00074242040.012
purine ribonucleoside catabolic processGO:00461301120.012
positive regulation of cell cycleGO:0045787430.012
positive regulation of gtpase activityGO:0043547430.012
positive regulation of purine nucleotide metabolic processGO:1900544550.012
chromatin silencingGO:0006342760.012
male meiosisGO:0007140520.012
ubiquitin dependent protein catabolic processGO:0006511780.012
digestive system developmentGO:00551231490.012
purine ribonucleoside triphosphate catabolic processGO:00092071080.012
gtp metabolic processGO:0046039720.012
organic acid metabolic processGO:00060821030.011
positive regulation of cell differentiationGO:0045597640.011
response to uvGO:0009411240.011
purine nucleoside metabolic processGO:00422781270.011
regulation of phosphate metabolic processGO:00192202100.011
ectopic germ cell programmed cell deathGO:003523480.011
regulation of cell developmentGO:00602842150.011
cellular amino acid metabolic processGO:0006520610.011
protein polymerizationGO:0051258420.011
columnar cuboidal epithelial cell differentiationGO:00020652560.011
positive regulation of intracellular signal transductionGO:19025331160.011
maintenance of locationGO:0051235730.011
developmental cell growthGO:0048588520.011
epithelium migrationGO:00901321480.011
nucleoside triphosphate metabolic processGO:00091411200.011
regulation of transcription from rna polymerase ii promoterGO:00063573780.011
purine nucleoside triphosphate catabolic processGO:00091461080.011
positive regulation of cell deathGO:0010942690.011
ameboidal type cell migrationGO:00016671510.010
regulation of actin cytoskeleton organizationGO:0032956420.010
regulation of chromatin organizationGO:1902275320.010
defense response to bacteriumGO:00427421780.010
nucleoside metabolic processGO:00091161270.010
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.010
regulation of cellular amino acid metabolic processGO:000652100.010
protein import into nucleusGO:0006606510.010
metal ion transportGO:0030001740.010
response to radiationGO:00093141550.010
nucleoside catabolic processGO:00091641120.010
negative regulation of organelle organizationGO:0010639560.010
nitrogen compound transportGO:0071705850.010

RnrL disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.101
musculoskeletal system cancerDOID:006010000.084
connective tissue cancerDOID:20100.084
cancerDOID:16200.084
organ system cancerDOID:005068600.084
disease of cellular proliferationDOID:1456600.084
nervous system diseaseDOID:86300.044
central nervous system diseaseDOID:33100.015
neurodegenerative diseaseDOID:128900.014
disease of metabolismDOID:001466700.011