IMP: Integrative Multi-species Prediction

Drosophila melanogaster

39 known processes

T-cp1 (Dmel_CG5374)

Tcp1-like

(Aliases: CG5374,T-cpl,TCPA_DROME,CCT1,Tcp1,BEST:GH05123,Dmel\CG5374,gh05123,TCP-1alpha,Tcp-1)

FLYBASE: FBgn0003676
Entrez: 42649
UniProtKB: A4V391
UniProtKB: P12613

Process Predictions
Disease Predictions

T-cp1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
spindle assembly involved in mitosis	GO:0090307	50	0.728
single fertilization	GO:0007338	24	0.663	Mouse
spindle organization	GO:0007051	253	0.648
mitotic spindle organization	GO:0007052	220	0.531
larval development	GO:0002164	104	0.494	Worm
embryo development ending in birth or egg hatching	GO:0009792	152	0.494	Worm
cytoplasmic microtubule organization	GO:0031122	22	0.449
spindle assembly	GO:0051225	80	0.405
endocytosis	GO:0006897	310	0.359
organelle fission	GO:0048285	340	0.311
nuclear division	GO:0000280	332	0.233
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.231
cell motility	GO:0048870	251	0.223	Worm
cell recognition	GO:0008037	102	0.221	Mouse
protein complex assembly	GO:0006461	200	0.215
reproductive system development	GO:0061458	74	0.203	Worm
protein complex biogenesis	GO:0070271	201	0.201
development of primary sexual characteristics	GO:0045137	50	0.194	Worm
response to virus	GO:0009615	28	0.189
body morphogenesis	GO:0010171	2	0.181
sex differentiation	GO:0007548	81	0.153	Worm
fertilization	GO:0009566	26	0.133	Mouse
determination of adult lifespan	GO:0008340	137	0.126
vesicle mediated transport	GO:0016192	381	0.115
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.107
mitotic nuclear division	GO:0007067	213	0.099
protein destabilization	GO:0031648	2	0.098
positive regulation of cellular biosynthetic process	GO:0031328	316	0.097
programmed cell death	GO:0012501	257	0.097	Mouse Worm
apoptotic process	GO:0006915	159	0.094	Mouse Worm
aging	GO:0007568	143	0.093
multicellular organismal aging	GO:0010259	140	0.092
macromolecular complex assembly	GO:0065003	256	0.091
gonad development	GO:0008406	50	0.088	Worm
genitalia development	GO:0048806	26	0.082	Worm
transcription from rna polymerase ii promoter	GO:0006366	368	0.080
small molecule metabolic process	GO:0044281	305	0.079
nucleobase containing compound catabolic process	GO:0034655	165	0.076
negative regulation of cellular metabolic process	GO:0031324	382	0.076
organic cyclic compound catabolic process	GO:1901361	168	0.075
cellular catabolic process	GO:0044248	372	0.073
organic substance catabolic process	GO:1901575	308	0.070
negative regulation of gene expression	GO:0010629	387	0.067
regulation of organelle organization	GO:0033043	196	0.062
catabolic process	GO:0009056	409	0.059
macromolecule catabolic process	GO:0009057	161	0.058
reproductive structure development	GO:0048608	74	0.058	Worm
response to external biotic stimulus	GO:0043207	293	0.057
death	GO:0016265	284	0.055	Mouse Worm
single organism catabolic process	GO:0044712	228	0.053
localization of cell	GO:0051674	257	0.053	Worm
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.053
positive regulation of growth	GO:0045927	75	0.052
cellular macromolecular complex assembly	GO:0034622	153	0.049
positive regulation of rna metabolic process	GO:0051254	271	0.048
negative regulation of response to stimulus	GO:0048585	258	0.043
cellular protein complex assembly	GO:0043623	71	0.042
aromatic compound catabolic process	GO:0019439	166	0.041
cell death	GO:0008219	279	0.041	Mouse Worm
heterocycle catabolic process	GO:0046700	166	0.040
regulation of phosphorus metabolic process	GO:0051174	210	0.040
regulation of hydrolase activity	GO:0051336	97	0.039
centrosome duplication	GO:0051298	121	0.036
defense response	GO:0006952	300	0.035
response to other organism	GO:0051707	293	0.034
phosphorylation	GO:0016310	294	0.034
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.034
organonitrogen compound catabolic process	GO:1901565	128	0.033
trna aminoacylation	GO:0043039	2	0.031
receptor mediated endocytosis	GO:0006898	21	0.029	Worm
regulation of response to stress	GO:0080134	200	0.029
microtubule organizing center organization	GO:0031023	168	0.029
protein localization	GO:0008104	284	0.028	Mouse
regulation of immune response	GO:0050776	118	0.028
regulation of cellular catabolic process	GO:0031329	157	0.027
positive regulation of developmental growth	GO:0048639	62	0.027
positive regulation of multicellular organismal process	GO:0051240	143	0.027
positive regulation of macromolecule metabolic process	GO:0010604	405	0.026
regulation of catalytic activity	GO:0050790	185	0.026
negative regulation of cellular biosynthetic process	GO:0031327	277	0.026
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.025
response to radiation	GO:0009314	155	0.025
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.025
response to temperature stimulus	GO:0009266	106	0.024
organonitrogen compound metabolic process	GO:1901564	318	0.024
response to abiotic stimulus	GO:0009628	341	0.024
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.024
regulation of protein metabolic process	GO:0051246	256	0.024
cellular nitrogen compound catabolic process	GO:0044270	165	0.024
centrosome organization	GO:0051297	163	0.023
positive regulation of transcription dna templated	GO:0045893	266	0.023
regulation of molecular function	GO:0065009	217	0.022
organelle assembly	GO:0070925	198	0.022
positive regulation of gene expression	GO:0010628	290	0.022
response to light stimulus	GO:0009416	124	0.022
regulation of phosphate metabolic process	GO:0019220	210	0.021
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.021
cellular macromolecule localization	GO:0070727	220	0.021
regulation of developmental growth	GO:0048638	174	0.021
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.020
cell migration	GO:0016477	238	0.020	Worm
rna splicing	GO:0008380	83	0.020
protein modification process	GO:0036211	438	0.020
posttranscriptional regulation of gene expression	GO:0010608	145	0.019
regulation of multicellular organismal development	GO:2000026	414	0.019
purine nucleotide catabolic process	GO:0006195	109	0.019
actin filament based process	GO:0030029	220	0.019
ncrna metabolic process	GO:0034660	43	0.018
nucleoside triphosphate metabolic process	GO:0009141	120	0.018
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.018
mrna metabolic process	GO:0016071	124	0.018
immune response	GO:0006955	246	0.017
negative regulation of biosynthetic process	GO:0009890	277	0.017
carbohydrate derivative catabolic process	GO:1901136	118	0.017
positive regulation of developmental process	GO:0051094	143	0.017
nucleoside triphosphate catabolic process	GO:0009143	108	0.017
mrna splicing via spliceosome	GO:0000398	73	0.017
negative regulation of multicellular organismal process	GO:0051241	142	0.017
cellular macromolecule catabolic process	GO:0044265	136	0.017
taxis	GO:0042330	304	0.017
regulation of peptidase activity	GO:0052547	39	0.016
response to organic substance	GO:0010033	284	0.016
response to biotic stimulus	GO:0009607	294	0.016
positive regulation of catalytic activity	GO:0043085	118	0.016
dna metabolic process	GO:0006259	227	0.016
intracellular signal transduction	GO:0035556	300	0.016
multicellular organism growth	GO:0035264	46	0.016
developmental growth	GO:0048589	280	0.015
tube morphogenesis	GO:0035239	191	0.015
intermediate filament based process	GO:0045103	1	0.015
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.014
positive regulation of hydrolase activity	GO:0051345	78	0.014
regulation of proteolysis	GO:0030162	87	0.014
regulation of defense response	GO:0031347	102	0.014
regulation of growth	GO:0040008	233	0.014
phagocytosis	GO:0006909	215	0.014
regulation of cellular protein metabolic process	GO:0032268	243	0.014
carbohydrate derivative metabolic process	GO:1901135	217	0.014
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.014
meiotic cell cycle	GO:0051321	171	0.013
organophosphate metabolic process	GO:0019637	195	0.013
positive regulation of proteolysis	GO:0045862	52	0.013
peptidyl serine modification	GO:0018209	7	0.013
positive regulation of catabolic process	GO:0009896	105	0.013
glycosyl compound catabolic process	GO:1901658	112	0.013
nucleobase containing small molecule metabolic process	GO:0055086	174	0.013
regulation of response to external stimulus	GO:0032101	115	0.013
positive regulation of biosynthetic process	GO:0009891	316	0.013
regulation of catabolic process	GO:0009894	170	0.013
mitochondrion organization	GO:0007005	65	0.013
rna splicing via transesterification reactions	GO:0000375	73	0.012
chaperone mediated protein folding	GO:0061077	2	0.012
negative regulation of cell death	GO:0060548	81	0.012
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.012
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.012
single organism cellular localization	GO:1902580	180	0.012
cellular protein modification process	GO:0006464	438	0.012
purine nucleotide metabolic process	GO:0006163	146	0.012
positive regulation of cell motility	GO:2000147	3	0.012
single organism intracellular transport	GO:1902582	207	0.012
regulation of cellular ketone metabolic process	GO:0010565	3	0.011
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.011
protein phosphorylation	GO:0006468	169	0.011
negative regulation of multi organism process	GO:0043901	29	0.011
proteolysis	GO:0006508	192	0.011
cell proliferation	GO:0008283	299	0.011
nucleoside phosphate metabolic process	GO:0006753	162	0.011
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.011
innate immune response	GO:0045087	144	0.011
amine metabolic process	GO:0009308	12	0.011
regulation of purine nucleotide metabolic process	GO:1900542	62	0.011
regulation of innate immune response	GO:0045088	71	0.011
mrna processing	GO:0006397	104	0.010
negative regulation of neuron projection development	GO:0010977	9	0.010
positive regulation of response to stimulus	GO:0048584	323	0.010
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.010
dna replication	GO:0006260	48	0.010
defense response to other organism	GO:0098542	225	0.010
negative regulation of transcription factor import into nucleus	GO:0042992	4	0.010
nucleotide catabolic process	GO:0009166	109	0.010

T-cp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
benign neoplasm	DOID:0060072	0.016
disease of cellular proliferation	DOID:14566	0.016
disease of anatomical entity	DOID:7	0.010
disease of metabolism	DOID:0014667	0.010

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