IMP: Integrative Multi-species Prediction

Drosophila melanogaster

25 known processes

RhoBTB (Dmel_CG5701)

CG5701 gene product from transcript CG5701-RA

(Aliases: RhoGTPase,RhoX,CG5701,Dmel\CG5701)

FLYBASE: FBgn0036980
Entrez: 40249
UniProtKB: M9PG08
UniProtKB: M9PIB5
UniProtKB: Q9VPG7

Process Predictions
Disease Predictions

RhoBTB biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
encapsulation of foreign target	GO:0035010	38	0.980
secondary metabolic process	GO:0019748	75	0.885
pigment metabolic process	GO:0042440	84	0.776
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.539
immune effector process	GO:0002252	98	0.412
positive regulation of gtp catabolic process	GO:0033126	43	0.405
meiotic nuclear division	GO:0007126	151	0.363
positive regulation of gtpase activity	GO:0043547	43	0.361
melanotic encapsulation of foreign target	GO:0035011	30	0.291
ras protein signal transduction	GO:0007265	88	0.278
organic hydroxy compound metabolic process	GO:1901615	83	0.273
regulation of catalytic activity	GO:0050790	185	0.243
regulation of ras protein signal transduction	GO:0046578	93	0.242
positive regulation of ras gtpase activity	GO:0032320	36	0.238
cell proliferation	GO:0008283	299	0.232
purine nucleotide catabolic process	GO:0006195	109	0.213	Human
nucleoside phosphate catabolic process	GO:1901292	110	0.211	Human
cell motility	GO:0048870	251	0.204
defense response	GO:0006952	300	0.179
positive regulation of phosphorus metabolic process	GO:0010562	139	0.179
dna metabolic process	GO:0006259	227	0.174
cellular nitrogen compound catabolic process	GO:0044270	165	0.162	Human
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.160
organelle fission	GO:0048285	340	0.160
purine containing compound metabolic process	GO:0072521	155	0.160	Human
nucleotide catabolic process	GO:0009166	109	0.158	Human
positive regulation of phosphate metabolic process	GO:0045937	139	0.143
melanization defense response	GO:0035006	45	0.142
positive regulation of catabolic process	GO:0009896	105	0.134
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.130	Human
organic cyclic compound catabolic process	GO:1901361	168	0.127	Human
heterocycle catabolic process	GO:0046700	166	0.115	Human
regulation of nucleotide metabolic process	GO:0006140	62	0.111
nucleus localization	GO:0051647	34	0.111
multi organism behavior	GO:0051705	175	0.108
regulation of nucleotide catabolic process	GO:0030811	48	0.107
purine nucleotide metabolic process	GO:0006163	146	0.104	Human
organonitrogen compound catabolic process	GO:1901565	128	0.094	Human
neuroblast proliferation	GO:0007405	74	0.091
regulation of hydrolase activity	GO:0051336	97	0.091
organophosphate metabolic process	GO:0019637	195	0.084	Human
endocytosis	GO:0006897	310	0.084
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.081
regulation of phosphate metabolic process	GO:0019220	210	0.081
organic substance catabolic process	GO:1901575	308	0.080	Human
gtp metabolic process	GO:0046039	72	0.080
modification dependent protein catabolic process	GO:0019941	78	0.077
nuclear division	GO:0000280	332	0.077
glycosyl compound catabolic process	GO:1901658	112	0.076	Human
nucleoside triphosphate catabolic process	GO:0009143	108	0.075	Human
ribonucleotide catabolic process	GO:0009261	109	0.074	Human
intracellular signal transduction	GO:0035556	300	0.073
cellular catabolic process	GO:0044248	372	0.072	Human
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.071	Human
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.071
regulation of intracellular signal transduction	GO:1902531	236	0.070
positive regulation of response to stimulus	GO:0048584	323	0.068
purine ribonucleoside catabolic process	GO:0046130	112	0.068	Human
regulation of catabolic process	GO:0009894	170	0.068
regulation of phosphorus metabolic process	GO:0051174	210	0.067
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.066
small gtpase mediated signal transduction	GO:0007264	88	0.065
vesicle mediated transport	GO:0016192	381	0.065	Human
regulation of nucleoside metabolic process	GO:0009118	50	0.065
guanosine containing compound metabolic process	GO:1901068	74	0.064
purine ribonucleotide catabolic process	GO:0009154	109	0.064	Human
organonitrogen compound metabolic process	GO:1901564	318	0.062	Human
protein k48 linked ubiquitination	GO:0070936	3	0.061
regulation of gtpase activity	GO:0043087	44	0.059
secretion	GO:0046903	109	0.059
glycosyl compound metabolic process	GO:1901657	127	0.057	Human
biological adhesion	GO:0022610	138	0.056
regulation of cell cycle process	GO:0010564	181	0.055
establishment of localization in cell	GO:0051649	402	0.055	Human
regulation of erk1 and erk2 cascade	GO:0070372	39	0.053
purine nucleoside catabolic process	GO:0006152	112	0.053	Human
regulation of mapk cascade	GO:0043408	92	0.052
regulation of meiosis	GO:0040020	3	0.051
protein modification process	GO:0036211	438	0.051
regulation of molecular function	GO:0065009	217	0.050
immune system process	GO:0002376	347	0.050
positive regulation of catalytic activity	GO:0043085	118	0.049
ommochrome biosynthetic process	GO:0006727	19	0.049
catabolic process	GO:0009056	409	0.048	Human
cellular macromolecule catabolic process	GO:0044265	136	0.047
skin development	GO:0043588	65	0.047
positive regulation of cellular catabolic process	GO:0031331	95	0.045
positive regulation of nucleotide catabolic process	GO:0030813	46	0.044
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.044
positive regulation of nucleotide metabolic process	GO:0045981	55	0.044
gtp catabolic process	GO:0006184	72	0.043
nucleoside catabolic process	GO:0009164	112	0.043	Human
cellular protein modification process	GO:0006464	438	0.043
regulation of immune system process	GO:0002682	176	0.043
positive regulation of transcription dna templated	GO:0045893	266	0.041
carbohydrate derivative catabolic process	GO:1901136	118	0.041	Human
protein modification by small protein conjugation or removal	GO:0070647	106	0.040
nucleobase containing compound catabolic process	GO:0034655	165	0.039	Human
ribonucleotide metabolic process	GO:0009259	145	0.038	Human
phosphorylation	GO:0016310	294	0.037
neural precursor cell proliferation	GO:0061351	75	0.037
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.037	Human
erk1 and erk2 cascade	GO:0070371	39	0.036
regulation of rho protein signal transduction	GO:0035023	20	0.036
germarium derived egg chamber formation	GO:0007293	101	0.036
positive regulation of phosphorylation	GO:0042327	87	0.036
ribonucleoside metabolic process	GO:0009119	127	0.035	Human
mating behavior	GO:0007617	106	0.035
meiotic cell cycle	GO:0051321	171	0.035
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.035
positive regulation of molecular function	GO:0044093	136	0.034
regulation of phosphorylation	GO:0042325	147	0.033
regulation of ras gtpase activity	GO:0032318	38	0.033
regulation of gtp catabolic process	GO:0033124	44	0.033
purine ribonucleotide metabolic process	GO:0009150	145	0.033	Human
regulation of growth	GO:0040008	233	0.033
nucleotide metabolic process	GO:0009117	161	0.032	Human
imaginal disc derived appendage development	GO:0048737	399	0.032
response to external biotic stimulus	GO:0043207	293	0.031
regulation of cell cycle	GO:0051726	291	0.031
body morphogenesis	GO:0010171	2	0.031
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.030	Human
regulation of cellular localization	GO:0060341	136	0.030
regulation of organelle organization	GO:0033043	196	0.029
regulation of purine nucleotide catabolic process	GO:0033121	48	0.029
positive regulation of cellular biosynthetic process	GO:0031328	316	0.029
signal transduction by phosphorylation	GO:0023014	107	0.029
guanosine containing compound catabolic process	GO:1901069	74	0.029
negative regulation of gene expression	GO:0010629	387	0.028
regulation of hemocyte proliferation	GO:0035206	37	0.028
purine nucleoside metabolic process	GO:0042278	127	0.028	Human
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.028
actin cytoskeleton organization	GO:0030036	206	0.028
nucleobase containing small molecule metabolic process	GO:0055086	174	0.027	Human
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.027	Human
tube development	GO:0035295	244	0.027
regulation of cell proliferation	GO:0042127	163	0.027
centrosome cycle	GO:0007098	137	0.026
centrosome duplication	GO:0051298	121	0.026
regulation of nervous system development	GO:0051960	248	0.025
oocyte differentiation	GO:0009994	145	0.025
localization of cell	GO:0051674	257	0.025
cell adhesion	GO:0007155	136	0.024
melanin metabolic process	GO:0006582	47	0.024
regulation of gene expression epigenetic	GO:0040029	128	0.024
response to other organism	GO:0051707	293	0.023
sister chromatid segregation	GO:0000819	92	0.023
positive regulation of gene expression	GO:0010628	290	0.023
small molecule metabolic process	GO:0044281	305	0.023	Human
positive regulation of rna biosynthetic process	GO:1902680	266	0.022
regulation of purine nucleotide metabolic process	GO:1900542	62	0.022
epithelial cell differentiation	GO:0030855	322	0.022
chromosome segregation	GO:0007059	157	0.022
epithelial cell development	GO:0002064	274	0.022
formation of a compartment boundary	GO:0060288	4	0.021
regulation of multicellular organismal development	GO:2000026	414	0.021
regulation of mitotic cell cycle	GO:0007346	190	0.021
single organism catabolic process	GO:0044712	228	0.021	Human
single organism behavior	GO:0044708	391	0.021
regulation of protein transport	GO:0051223	57	0.021
positive regulation of signal transduction	GO:0009967	223	0.020
posttranscriptional regulation of gene expression	GO:0010608	145	0.020
purine ribonucleoside metabolic process	GO:0046128	127	0.020	Human
ribose phosphate metabolic process	GO:0019693	145	0.020	Human
organophosphate catabolic process	GO:0046434	112	0.020	Human
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.020
fertilization	GO:0009566	26	0.020
endosomal transport	GO:0016197	44	0.020	Human
mitotic nuclear division	GO:0007067	213	0.020
cellular macromolecular complex assembly	GO:0034622	153	0.019
meiotic cell cycle process	GO:1903046	132	0.019
aromatic compound catabolic process	GO:0019439	166	0.019	Human
mapk cascade	GO:0000165	107	0.019
positive regulation of hydrolase activity	GO:0051345	78	0.019
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.018
rho protein signal transduction	GO:0007266	14	0.018
immune response	GO:0006955	246	0.018
cellular macromolecule localization	GO:0070727	220	0.017
positive regulation of cellular component biogenesis	GO:0044089	80	0.017
cellular response to dna damage stimulus	GO:0006974	223	0.017
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.017
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.017
regulation of cell differentiation	GO:0045595	302	0.017
positive regulation of nucleoside metabolic process	GO:0045979	47	0.017
regulation of localization	GO:0032879	275	0.017
negative regulation of cell cycle phase transition	GO:1901988	103	0.016
negative regulation of cell death	GO:0060548	81	0.016
regionalization	GO:0003002	416	0.016
regulation of programmed cell death	GO:0043067	152	0.016
response to abiotic stimulus	GO:0009628	341	0.016
response to biotic stimulus	GO:0009607	294	0.016
regulation of striated muscle contraction	GO:0006942	2	0.016
nucleoside phosphate metabolic process	GO:0006753	162	0.016	Human
regulation of protein ubiquitination	GO:0031396	22	0.015
regulation of receptor mediated endocytosis	GO:0048259	9	0.014
death	GO:0016265	284	0.014
establishment of protein localization	GO:0045184	163	0.014
nucleoside triphosphate metabolic process	GO:0009141	120	0.014	Human
positive regulation of mapk cascade	GO:0043410	63	0.014
single fertilization	GO:0007338	24	0.014
response to organic substance	GO:0010033	284	0.014
regulation of protein metabolic process	GO:0051246	256	0.014
regulation of cellular protein metabolic process	GO:0032268	243	0.014
positive regulation of intracellular signal transduction	GO:1902533	116	0.013
response to wounding	GO:0009611	94	0.013
synaptic transmission	GO:0007268	288	0.013
flight behavior	GO:0007629	26	0.013
centrosome organization	GO:0051297	163	0.013
positive regulation of neuron projection regeneration	GO:0070572	3	0.013
mitotic cell cycle checkpoint	GO:0007093	88	0.013
regulation of rab protein signal transduction	GO:0032483	7	0.013
growth	GO:0040007	359	0.013
mitochondrial membrane organization	GO:0007006	3	0.013
negative regulation of response to stimulus	GO:0048585	258	0.013
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.013
positive regulation of signaling	GO:0023056	243	0.013
g protein coupled receptor signaling pathway	GO:0007186	136	0.012
segmentation	GO:0035282	207	0.012
epithelial cell migration	GO:0010631	148	0.012
regulation of response to stress	GO:0080134	200	0.012
negative regulation of cellular metabolic process	GO:0031324	382	0.012
establishment of nucleus localization	GO:0040023	26	0.012
regulation of transport	GO:0051049	181	0.012
regulation of cell development	GO:0060284	215	0.012
carbohydrate derivative metabolic process	GO:1901135	217	0.012	Human
central nervous system development	GO:0007417	201	0.012
embryo development ending in birth or egg hatching	GO:0009792	152	0.012
forebrain development	GO:0030900	2	0.012
ribonucleoside catabolic process	GO:0042454	112	0.012	Human
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.012	Human
carboxylic acid metabolic process	GO:0019752	92	0.012
protein transport	GO:0015031	155	0.012
positive regulation of biosynthetic process	GO:0009891	316	0.011
regulation of cell cycle phase transition	GO:1901987	130	0.011
cell migration	GO:0016477	238	0.011
mating	GO:0007618	120	0.011
regulation of cellular catabolic process	GO:0031329	157	0.011
tissue morphogenesis	GO:0048729	297	0.011
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.011
regulation of protein modification process	GO:0031399	112	0.011
blastoderm segmentation	GO:0007350	159	0.011
cellular ketone metabolic process	GO:0042180	24	0.011
protein localization	GO:0008104	284	0.011
dna repair	GO:0006281	54	0.011
developmental growth	GO:0048589	280	0.011
post embryonic appendage morphogenesis	GO:0035120	385	0.011
imaginal disc derived wing morphogenesis	GO:0007476	337	0.011
ocellus pigment metabolic process	GO:0046158	19	0.011
regulation of cell division	GO:0051302	72	0.010
cell maturation	GO:0048469	144	0.010
notch signaling pathway	GO:0007219	120	0.010
lipid metabolic process	GO:0006629	121	0.010
cardiovascular system development	GO:0072358	82	0.010
respiratory system development	GO:0060541	213	0.010
adult locomotory behavior	GO:0008344	76	0.010
response to oxidative stress	GO:0006979	86	0.010
stem cell division	GO:0017145	69	0.010

RhoBTB disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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