IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

DNApol-alpha73 (Dmel_CG5923)

DNA polymerase alpha 73kD

(Aliases: DNApol-alpha72,DNApolalpha,Dmel\CG5923,Dmpol alpha,DNApol-alpha,DNA polalpha,CG5923,Pol,DNA pol-73,POLA,polalpha,pol alpha,Polalpha)

FLYBASE: FBgn0005696
Entrez: 43278
UniProtKB: Q9VB62

Process Predictions
Disease Predictions

DNApol-alpha73 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dna replication	GO:0006260	48	0.812	Yeast
cellular response to dna damage stimulus	GO:0006974	223	0.553
dna metabolic process	GO:0006259	227	0.417	Yeast
nuclear dna replication	GO:0033260	1	0.406
regulation of cell cycle process	GO:0010564	181	0.393
regulation of cell cycle	GO:0051726	291	0.357
dna repair	GO:0006281	54	0.352
negative regulation of cell cycle process	GO:0010948	109	0.348
mitotic cell cycle phase transition	GO:0044772	138	0.304
regulation of cell cycle phase transition	GO:1901987	130	0.288
cell cycle dna replication	GO:0044786	23	0.264
mitotic g2 m transition checkpoint	GO:0044818	70	0.253
mitotic dna damage checkpoint	GO:0044773	74	0.195
cellular catabolic process	GO:0044248	372	0.184
dna integrity checkpoint	GO:0031570	81	0.176
negative regulation of gene expression	GO:0010629	387	0.170
negative regulation of cellular metabolic process	GO:0031324	382	0.155
mitotic dna integrity checkpoint	GO:0044774	75	0.141
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.138
catabolic process	GO:0009056	409	0.137
heterocycle catabolic process	GO:0046700	166	0.119
negative regulation of cell cycle phase transition	GO:1901988	103	0.118
positive regulation of cellular biosynthetic process	GO:0031328	316	0.118
regulation of molecular function	GO:0065009	217	0.110
organic substance catabolic process	GO:1901575	308	0.109
dna dependent dna replication	GO:0006261	17	0.108	Yeast
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.107
mitotic g2 dna damage checkpoint	GO:0007095	69	0.106
protein modification process	GO:0036211	438	0.102
organonitrogen compound metabolic process	GO:1901564	318	0.097
negative regulation of cell communication	GO:0010648	223	0.096
mitotic nuclear division	GO:0007067	213	0.094
cellular nitrogen compound catabolic process	GO:0044270	165	0.091
positive regulation of biosynthetic process	GO:0009891	316	0.091
cell cycle phase transition	GO:0044770	140	0.088
spindle organization	GO:0007051	253	0.087
nuclear division	GO:0000280	332	0.083
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.081
macromolecule catabolic process	GO:0009057	161	0.078
eye development	GO:0001654	323	0.072
cell cycle checkpoint	GO:0000075	95	0.072
negative regulation of signaling	GO:0023057	219	0.072
organelle fission	GO:0048285	340	0.070
regulation of localization	GO:0032879	275	0.069
regulation of mitotic cell cycle	GO:0007346	190	0.068
g2 dna damage checkpoint	GO:0031572	69	0.066
centrosome organization	GO:0051297	163	0.066
double strand break repair	GO:0006302	26	0.063
small molecule metabolic process	GO:0044281	305	0.063
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.063
regulation of dna metabolic process	GO:0051052	34	0.062
negative regulation of cell cycle	GO:0045786	116	0.061
negative regulation of mitotic cell cycle	GO:0045930	109	0.060
negative regulation of rna biosynthetic process	GO:1902679	240	0.060
cell proliferation	GO:0008283	299	0.059
negative regulation of rna metabolic process	GO:0051253	251	0.058
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.058
spindle elongation	GO:0051231	83	0.057
negative regulation of response to stimulus	GO:0048585	258	0.057
organic cyclic compound catabolic process	GO:1901361	168	0.057
mitotic cell cycle checkpoint	GO:0007093	88	0.055
nucleobase containing compound catabolic process	GO:0034655	165	0.054
dna recombination	GO:0006310	32	0.053
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.053
dna damage checkpoint	GO:0000077	78	0.051
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.051
eye morphogenesis	GO:0048592	260	0.049
regulation of catalytic activity	GO:0050790	185	0.049
single organism biosynthetic process	GO:0044711	206	0.048
regulation of catabolic process	GO:0009894	170	0.047
dna endoreduplication	GO:0042023	22	0.047
aromatic compound catabolic process	GO:0019439	166	0.047
regulation of protein metabolic process	GO:0051246	256	0.046
death	GO:0016265	284	0.046
negative regulation of signal transduction	GO:0009968	206	0.046
macromolecular complex assembly	GO:0065003	256	0.045
cell division	GO:0051301	248	0.044
cellular macromolecule catabolic process	GO:0044265	136	0.042
proteolysis	GO:0006508	192	0.040
dna biosynthetic process	GO:0071897	24	0.040	Yeast
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.040
positive regulation of rna biosynthetic process	GO:1902680	266	0.038
single organism catabolic process	GO:0044712	228	0.038
dna replication initiation	GO:0006270	6	0.037	Yeast
growth	GO:0040007	359	0.037
multicellular organism growth	GO:0035264	46	0.035
organic substance transport	GO:0071702	257	0.034
positive regulation of macromolecule metabolic process	GO:0010604	405	0.034
negative regulation of biosynthetic process	GO:0009890	277	0.033
nucleotide metabolic process	GO:0009117	161	0.032
cellular protein modification process	GO:0006464	438	0.031
nucleobase containing small molecule metabolic process	GO:0055086	174	0.030
nucleoside phosphate metabolic process	GO:0006753	162	0.030
camera type eye development	GO:0043010	4	0.029
tissue morphogenesis	GO:0048729	297	0.029
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.029
programmed cell death	GO:0012501	257	0.029
nucleoside metabolic process	GO:0009116	127	0.029
regulation of gene expression epigenetic	GO:0040029	128	0.028
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.028
protein dna complex assembly	GO:0065004	63	0.027
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.027
negative regulation of cellular biosynthetic process	GO:0031327	277	0.027
mitotic spindle elongation	GO:0000022	81	0.026
purine containing compound metabolic process	GO:0072521	155	0.026
protein localization	GO:0008104	284	0.026
post embryonic appendage morphogenesis	GO:0035120	385	0.025
regulation of cellular response to stress	GO:0080135	89	0.025
purine nucleotide metabolic process	GO:0006163	146	0.025
mitotic spindle organization	GO:0007052	220	0.025
positive regulation of molecular function	GO:0044093	136	0.025
cell motility	GO:0048870	251	0.024
protein catabolic process	GO:0030163	101	0.024
protein complex biogenesis	GO:0070271	201	0.023
organonitrogen compound catabolic process	GO:1901565	128	0.023
ribonucleotide catabolic process	GO:0009261	109	0.022
negative regulation of transcription dna templated	GO:0045892	237	0.022
regulation of cell differentiation	GO:0045595	302	0.022
establishment of localization in cell	GO:0051649	402	0.022
purine ribonucleotide catabolic process	GO:0009154	109	0.022
compound eye development	GO:0048749	307	0.021
nucleotide catabolic process	GO:0009166	109	0.021
regulation of cell morphogenesis	GO:0022604	163	0.021
purine nucleotide catabolic process	GO:0006195	109	0.021
compound eye morphogenesis	GO:0001745	249	0.020
intracellular signal transduction	GO:0035556	300	0.020
single organism cellular localization	GO:1902580	180	0.020
membrane organization	GO:0061024	112	0.020
protein transport	GO:0015031	155	0.020
ubiquitin dependent protein catabolic process	GO:0006511	78	0.020
cell death	GO:0008219	279	0.019
positive regulation of catalytic activity	GO:0043085	118	0.019
establishment of cell polarity	GO:0030010	40	0.019
cellular protein localization	GO:0034613	160	0.019
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.019
microtubule organizing center organization	GO:0031023	168	0.019
modification dependent macromolecule catabolic process	GO:0043632	79	0.019
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.019
glycosyl compound metabolic process	GO:1901657	127	0.019
morphogenesis of an epithelium	GO:0002009	276	0.018
purine ribonucleotide metabolic process	GO:0009150	145	0.018
ribonucleoside catabolic process	GO:0042454	112	0.018
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.018
heart development	GO:0007507	82	0.018
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.018
dendrite morphogenesis	GO:0048813	199	0.017
regulation of cellular protein metabolic process	GO:0032268	243	0.017
regulation of dna replication	GO:0006275	13	0.017
nucleoside triphosphate metabolic process	GO:0009141	120	0.017
purine ribonucleoside metabolic process	GO:0046128	127	0.017
spermatogenesis	GO:0007283	200	0.017
rna processing	GO:0006396	147	0.017
regulation of phosphorus metabolic process	GO:0051174	210	0.017
developmental growth	GO:0048589	280	0.017
regulation of intracellular signal transduction	GO:1902531	236	0.017
appendage morphogenesis	GO:0035107	397	0.016
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.016
regulation of cell division	GO:0051302	72	0.016
purine nucleoside metabolic process	GO:0042278	127	0.016
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.016
regulation of transport	GO:0051049	181	0.016
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.016
intracellular transport	GO:0046907	228	0.015
cellular macromolecular complex assembly	GO:0034622	153	0.015
double strand break repair via homologous recombination	GO:0000724	13	0.015
nucleoside monophosphate metabolic process	GO:0009123	52	0.015
regulation of hydrolase activity	GO:0051336	97	0.015
centrosome duplication	GO:0051298	121	0.015
regulation of cellular catabolic process	GO:0031329	157	0.015
proteasomal protein catabolic process	GO:0010498	59	0.015
sensory organ morphogenesis	GO:0090596	260	0.015
organophosphate catabolic process	GO:0046434	112	0.015
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.015
purine ribonucleoside catabolic process	GO:0046130	112	0.015
double strand break repair via nonhomologous end joining	GO:0006303	5	0.015
chromosome organization	GO:0051276	360	0.014	Yeast
endocytosis	GO:0006897	310	0.014
chromatin organization	GO:0006325	207	0.014
dendrite development	GO:0016358	204	0.014
organophosphate metabolic process	GO:0019637	195	0.014
positive regulation of multicellular organismal process	GO:0051240	143	0.014
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.014
regulation of protein catabolic process	GO:0042176	55	0.014
nucleoside catabolic process	GO:0009164	112	0.014
protein processing	GO:0016485	68	0.014
nucleoside triphosphate catabolic process	GO:0009143	108	0.014
purine containing compound catabolic process	GO:0072523	112	0.014
protein complex assembly	GO:0006461	200	0.013
response to nutrient levels	GO:0031667	114	0.013
regulation of organelle organization	GO:0033043	196	0.013
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.013
positive regulation of protein metabolic process	GO:0051247	128	0.013
regulation of growth	GO:0040008	233	0.013
regulation of nervous system development	GO:0051960	248	0.013
response to biotic stimulus	GO:0009607	294	0.013
homeostatic process	GO:0042592	199	0.013	Yeast
transcription from rna polymerase ii promoter	GO:0006366	368	0.013
single organism behavior	GO:0044708	391	0.013
protein phosphorylation	GO:0006468	169	0.013
cellular protein complex assembly	GO:0043623	71	0.012
positive regulation of gene expression	GO:0010628	290	0.012
compound eye photoreceptor cell differentiation	GO:0001751	140	0.012
regulation of multicellular organismal development	GO:2000026	414	0.012
negative regulation of dna metabolic process	GO:0051053	12	0.012
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.012
reproductive structure development	GO:0048608	74	0.012
mrna metabolic process	GO:0016071	124	0.012
cellular amino acid metabolic process	GO:0006520	61	0.012
positive regulation of phosphorus metabolic process	GO:0010562	139	0.012
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.012
regulation of phosphate metabolic process	GO:0019220	210	0.012
ribonucleoside metabolic process	GO:0009119	127	0.012
carbohydrate derivative catabolic process	GO:1901136	118	0.012
response to oxygen containing compound	GO:1901700	200	0.012
establishment of protein localization	GO:0045184	163	0.012
protein targeting	GO:0006605	64	0.012
positive regulation of cell cycle process	GO:0090068	28	0.012
glutamine family amino acid catabolic process	GO:0009065	3	0.012
establishment of protein localization to organelle	GO:0072594	62	0.012
positive regulation of phosphate metabolic process	GO:0045937	139	0.012
detection of monosaccharide stimulus	GO:0034287	1	0.011
ribose phosphate metabolic process	GO:0019693	145	0.011
guanosine containing compound catabolic process	GO:1901069	74	0.011
salivary gland development	GO:0007431	162	0.011
vesicle mediated transport	GO:0016192	381	0.011
ncrna 3 end processing	GO:0043628	17	0.011
respiratory system development	GO:0060541	213	0.011
positive regulation of rna metabolic process	GO:0051254	271	0.010
gtp metabolic process	GO:0046039	72	0.010
positive regulation of cell cycle	GO:0045787	43	0.010
g1 s transition of mitotic cell cycle	GO:0000082	31	0.010
nucleoside phosphate catabolic process	GO:1901292	110	0.010
ribonucleotide metabolic process	GO:0009259	145	0.010

DNApol-alpha73 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	nervous system disease	DOID:863	0	0.017
	disease of anatomical entity	DOID:7	0	0.017

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