IMP: Integrative Multi-species Prediction

Drosophila melanogaster

104 known processes

CycA (Dmel_CG5940)

Cyclin A

(Aliases: hari,1329/16,CLD3,0046/23,0545/13,l(3)183,l(3)j3C8,anon-WO0140519.128,1449/05,l(3)neo114,0245/34,CYCA,l(3)rsg11,0521/06,0104/07,0040/24,Dmel\CG5940,rsg11,S(rux)3B,0033/02,DmcycA,l(3)68Ea,l(3)03946,Cyc A,cycA,CG5940)

FLYBASE: FBgn0000404
Entrez: 39340
UniProtKB: P14785
UniProtKB: M9NFR3

Process Predictions
Disease Predictions

CycA biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
oocyte maturation	GO:0001556	3	0.998
regulation of multicellular organismal development	GO:2000026	414	0.993
mitotic nuclear division	GO:0007067	213	0.993
cell motility	GO:0048870	251	0.993
digestive tract morphogenesis	GO:0048546	127	0.992
respiratory system development	GO:0060541	213	0.990
tube morphogenesis	GO:0035239	191	0.988
nuclear division	GO:0000280	332	0.984
chromosome organization	GO:0051276	360	0.983
oocyte differentiation	GO:0009994	145	0.979
axonogenesis	GO:0007409	290	0.976
meiotic chromosome segregation	GO:0045132	59	0.972
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.971	Mouse
central nervous system development	GO:0007417	201	0.962
axon development	GO:0061564	297	0.960
cell migration	GO:0016477	238	0.959
tube development	GO:0035295	244	0.954
protein modification process	GO:0036211	438	0.950
cell cycle dna replication	GO:0044786	23	0.946
dna conformation change	GO:0071103	105	0.935
dendrite morphogenesis	GO:0048813	199	0.935
gliogenesis	GO:0042063	80	0.924
positive regulation of cellular biosynthetic process	GO:0031328	316	0.917	Mouse
negative regulation of cellular metabolic process	GO:0031324	382	0.910
embryonic morphogenesis	GO:0048598	206	0.903
regulation of cell division	GO:0051302	72	0.901
positive regulation of rna metabolic process	GO:0051254	271	0.893	Mouse
positive regulation of rna biosynthetic process	GO:1902680	266	0.888	Mouse
tissue morphogenesis	GO:0048729	297	0.883
chromosome segregation	GO:0007059	157	0.882
morphogenesis of an epithelium	GO:0002009	276	0.882
mitotic sister chromatid separation	GO:0051306	30	0.865
regulation of neuron differentiation	GO:0045664	103	0.845
regulation of neurogenesis	GO:0050767	158	0.842
positive regulation of mitotic sister chromatid separation	GO:1901970	10	0.820
neuron projection guidance	GO:0097485	241	0.819
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.815
dna packaging	GO:0006323	91	0.797
spindle organization	GO:0007051	253	0.783
meiotic cell cycle process	GO:1903046	132	0.765
establishment of localization in cell	GO:0051649	402	0.744
organelle fission	GO:0048285	340	0.724
sensory organ precursor cell division	GO:0045035	10	0.717
regulation of organelle organization	GO:0033043	196	0.711
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.704	Mouse
regulation of cell differentiation	GO:0045595	302	0.697
localization of cell	GO:0051674	257	0.663
organophosphate metabolic process	GO:0019637	195	0.661
spindle assembly	GO:0051225	80	0.658
regulation of cell development	GO:0060284	215	0.657
regulation of cellular component biogenesis	GO:0044087	201	0.650
female meiotic division	GO:0007143	70	0.649
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.643
positive regulation of metaphase anaphase transition of cell cycle	GO:1902101	10	0.642
macromolecular complex assembly	GO:0065003	256	0.642
sister chromatid segregation	GO:0000819	92	0.637
regulation of mitosis	GO:0007088	56	0.637
protein complex biogenesis	GO:0070271	201	0.622
regulation of nuclear division	GO:0051783	58	0.619
digestive system development	GO:0055123	149	0.616
oocyte development	GO:0048599	124	0.613
regulation of protein metabolic process	GO:0051246	256	0.611
positive regulation of chromosome segregation	GO:0051984	10	0.607
segmentation	GO:0035282	207	0.606
regulation of proteasomal protein catabolic process	GO:0061136	39	0.598
regulation of anatomical structure size	GO:0090066	163	0.595
mitotic cytokinesis	GO:0000281	50	0.588
organelle localization	GO:0051640	148	0.582
organonitrogen compound metabolic process	GO:1901564	318	0.580
multicellular organismal reproductive behavior	GO:0033057	110	0.567
glial cell differentiation	GO:0010001	35	0.565
regulation of cellular catabolic process	GO:0031329	157	0.563
meiotic nuclear division	GO:0007126	151	0.559
axon guidance	GO:0007411	233	0.553
negative regulation of phosphorus metabolic process	GO:0010563	45	0.541
regulation of catabolic process	GO:0009894	170	0.536
death	GO:0016265	284	0.531
dendrite development	GO:0016358	204	0.526
negative regulation of cell cycle	GO:0045786	116	0.523
mitotic spindle organization	GO:0007052	220	0.513
embryo development ending in birth or egg hatching	GO:0009792	152	0.493	Worm
epithelial tube morphogenesis	GO:0060562	88	0.489
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.487
regulation of cellular localization	GO:0060341	136	0.477
meiotic cell cycle	GO:0051321	171	0.472
regulation of phosphate metabolic process	GO:0019220	210	0.471
cell division	GO:0051301	248	0.471
cell death	GO:0008219	279	0.458
syncytial blastoderm mitotic cell cycle	GO:0035186	21	0.458
positive regulation of neurogenesis	GO:0050769	41	0.458
regulation of nervous system development	GO:0051960	248	0.457
cellular protein modification process	GO:0006464	438	0.456
organelle assembly	GO:0070925	198	0.454
neural precursor cell proliferation	GO:0061351	75	0.453
digestive tract development	GO:0048565	149	0.447
morphogenesis of embryonic epithelium	GO:0016331	94	0.444
single organism catabolic process	GO:0044712	228	0.444
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.443
positive regulation of catabolic process	GO:0009896	105	0.440
chromosome separation	GO:0051304	42	0.439
regulation of mitotic sister chromatid separation	GO:0010965	28	0.430
response to abiotic stimulus	GO:0009628	341	0.430
taxis	GO:0042330	304	0.425
negative regulation of signal transduction	GO:0009968	206	0.424
regulation of phosphorus metabolic process	GO:0051174	210	0.423
immune system process	GO:0002376	347	0.420
mitotic cell cycle phase transition	GO:0044772	138	0.414
negative regulation of mitotic cell cycle	GO:0045930	109	0.411
phosphorylation	GO:0016310	294	0.409
regulation of catalytic activity	GO:0050790	185	0.404
positive regulation of mitotic metaphase anaphase transition	GO:0045842	10	0.403
embryonic pattern specification	GO:0009880	174	0.401
chemotaxis	GO:0006935	249	0.396
regulation of cell cycle	GO:0051726	291	0.392
response to external biotic stimulus	GO:0043207	293	0.392
positive regulation of protein metabolic process	GO:0051247	128	0.389
intracellular signal transduction	GO:0035556	300	0.384	Human
positive regulation of biosynthetic process	GO:0009891	316	0.377	Mouse
cellular response to chemical stimulus	GO:0070887	199	0.376
open tracheal system development	GO:0007424	204	0.375
response to ethanol	GO:0045471	59	0.374
establishment of organelle localization	GO:0051656	122	0.365
neuroblast division	GO:0055057	35	0.362
determination of adult lifespan	GO:0008340	137	0.354
negative regulation of phosphate metabolic process	GO:0045936	45	0.349
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.348
response to organic substance	GO:0010033	284	0.342
neuroblast proliferation	GO:0007405	74	0.341
regulation of localization	GO:0032879	275	0.333
meiotic cell cycle phase transition	GO:0044771	4	0.331
maintenance of location	GO:0051235	73	0.329
regulation of molecular function	GO:0065009	217	0.328
cellular catabolic process	GO:0044248	372	0.325
chromosome movement towards spindle pole	GO:0051305	4	0.324
meiosis i	GO:0007127	59	0.324
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.324
regulation of exit from mitosis	GO:0007096	7	0.323
intracellular transport	GO:0046907	228	0.319
regulation of cell cycle process	GO:0010564	181	0.318
positive regulation of phosphorus metabolic process	GO:0010562	139	0.318
metaphase anaphase transition of cell cycle	GO:0044784	28	0.310
regulation of protein serine threonine kinase activity	GO:0071900	25	0.308
negative regulation of gene expression	GO:0010629	387	0.306
regulation of sister chromatid segregation	GO:0033045	28	0.300
chromosome condensation	GO:0030261	41	0.296
protein phosphorylation	GO:0006468	169	0.291
negative regulation of developmental process	GO:0051093	201	0.287
regulation of nucleotide metabolic process	GO:0006140	62	0.286
positive regulation of developmental process	GO:0051094	143	0.285
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.285
regulation of developmental growth	GO:0048638	174	0.283
positive regulation of cellular protein metabolic process	GO:0032270	118	0.276
regulation of protein localization	GO:0032880	76	0.276
positive regulation of gene expression	GO:0010628	290	0.270	Mouse
positive regulation of mitotic cell cycle	GO:0045931	34	0.267
pole cell development	GO:0007277	26	0.255
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.255
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.255
negative regulation of transcription dna templated	GO:0045892	237	0.252
head development	GO:0060322	135	0.247
negative regulation of cell communication	GO:0010648	223	0.243
purine nucleoside catabolic process	GO:0006152	112	0.241
aging	GO:0007568	143	0.240
positive regulation of cell cycle	GO:0045787	43	0.239
cellular lipid metabolic process	GO:0044255	83	0.238
cellular response to dna damage stimulus	GO:0006974	223	0.236
protein localization	GO:0008104	284	0.231
cytokinesis	GO:0000910	90	0.229
asymmetric cell division	GO:0008356	37	0.229
malpighian tubule development	GO:0072002	64	0.228
response to other organism	GO:0051707	293	0.228
wound healing	GO:0042060	75	0.227
negative regulation of mitotic sister chromatid separation	GO:2000816	13	0.224
nucleotide catabolic process	GO:0009166	109	0.223
negative regulation of response to stimulus	GO:0048585	258	0.221
positive regulation of nucleoside metabolic process	GO:0045979	47	0.221
single organism biosynthetic process	GO:0044711	206	0.218
neuron recognition	GO:0008038	101	0.218
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.217
reproductive system development	GO:0061458	74	0.215	Worm
cell cycle phase transition	GO:0044770	140	0.214
organic substance catabolic process	GO:1901575	308	0.213
positive regulation of phosphorylation	GO:0042327	87	0.211
positive regulation of macromolecule metabolic process	GO:0010604	405	0.210	Mouse
protein maturation	GO:0051604	71	0.209
positive regulation of gtpase activity	GO:0043547	43	0.208
gastrulation	GO:0007369	70	0.208
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.207
positive regulation of growth	GO:0045927	75	0.207
negative regulation of meiotic cell cycle	GO:0051447	2	0.207
cell cycle g1 s phase transition	GO:0044843	31	0.206
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.203
regulation of cell proliferation	GO:0042127	163	0.200
positive regulation of nucleotide metabolic process	GO:0045981	55	0.196
negative regulation of neurogenesis	GO:0050768	53	0.196
rna localization	GO:0006403	115	0.195
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.193
response to toxic substance	GO:0009636	22	0.193
establishment of protein localization	GO:0045184	163	0.191
regulation of wnt signaling pathway	GO:0030111	68	0.190
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.187
positive regulation of multicellular organismal process	GO:0051240	143	0.186
nucleoside triphosphate catabolic process	GO:0009143	108	0.186
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.185
camera type eye morphogenesis	GO:0048593	2	0.185
lateral inhibition	GO:0046331	206	0.185
positive regulation of phosphate metabolic process	GO:0045937	139	0.184
response to biotic stimulus	GO:0009607	294	0.182
cell maturation	GO:0048469	144	0.182
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.180	Mouse
gonad development	GO:0008406	50	0.180	Worm
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.179
catabolic process	GO:0009056	409	0.178
regulation of meiosis	GO:0040020	3	0.177
negative regulation of cell differentiation	GO:0045596	143	0.175
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.175
dna recombination	GO:0006310	32	0.174
neuroblast fate determination	GO:0007400	12	0.174
positive regulation of cellular catabolic process	GO:0031331	95	0.172
negative regulation of cellular component organization	GO:0051129	108	0.170
hematopoietic or lymphoid organ development	GO:0048534	57	0.168
cellular response to organic substance	GO:0071310	132	0.166
negative regulation of cellular catabolic process	GO:0031330	34	0.165
regulation of protein transport	GO:0051223	57	0.164
stem cell proliferation	GO:0072089	88	0.163
locomotory behavior	GO:0007626	176	0.161
development of primary sexual characteristics	GO:0045137	50	0.161	Worm
reproductive structure development	GO:0048608	74	0.158	Worm
embryonic development via the syncytial blastoderm	GO:0001700	148	0.156
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.156
positive regulation of hydrolase activity	GO:0051345	78	0.156
regulation of intracellular protein transport	GO:0033157	46	0.155
regulation of chromosome organization	GO:0033044	64	0.154
positive regulation of cellular component organization	GO:0051130	156	0.154
purine ribonucleoside catabolic process	GO:0046130	112	0.153
regulation of proteolysis	GO:0030162	87	0.151
ribonucleoside catabolic process	GO:0042454	112	0.150
negative regulation of catabolic process	GO:0009895	36	0.149
positive regulation of protein phosphorylation	GO:0001934	34	0.147
vesicle mediated transport	GO:0016192	381	0.147
glycosyl compound catabolic process	GO:1901658	112	0.145
programmed cell death	GO:0012501	257	0.144
cell proliferation	GO:0008283	299	0.143
nucleoside catabolic process	GO:0009164	112	0.142
regulation of transferase activity	GO:0051338	58	0.142
regulation of cell cycle phase transition	GO:1901987	130	0.140
sex differentiation	GO:0007548	81	0.140	Worm
dna metabolic process	GO:0006259	227	0.139
glial cell migration	GO:0008347	31	0.138
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.135
attachment of spindle microtubules to kinetochore	GO:0008608	5	0.135
regulation of synapse organization	GO:0050807	110	0.134
stem cell development	GO:0048864	79	0.132
gland development	GO:0048732	191	0.132
germ cell migration	GO:0008354	43	0.131
response to oxygen containing compound	GO:1901700	200	0.130
regulation of protein kinase activity	GO:0045859	51	0.129
regulation of immune system process	GO:0002682	176	0.127
anterior posterior axis specification embryo	GO:0008595	103	0.126
g1 s transition of mitotic cell cycle	GO:0000082	31	0.124
peripheral nervous system development	GO:0007422	52	0.123
cell junction assembly	GO:0034329	42	0.123
microtubule anchoring	GO:0034453	11	0.123
regulation of mitotic cell cycle	GO:0007346	190	0.122
germarium derived female germ line cyst formation	GO:0030727	42	0.119
positive regulation of signal transduction	GO:0009967	223	0.118
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.118
multi multicellular organism process	GO:0044706	123	0.118
mitotic sister chromatid segregation	GO:0000070	87	0.117
small molecule metabolic process	GO:0044281	305	0.117
positive regulation of cell differentiation	GO:0045597	64	0.114
multi organism behavior	GO:0051705	175	0.114
protein modification by small protein conjugation or removal	GO:0070647	106	0.113
regulation of protein phosphorylation	GO:0001932	64	0.113
response to bacterium	GO:0009617	198	0.111
negative regulation of wnt signaling pathway	GO:0030178	28	0.110
negative regulation of cellular protein metabolic process	GO:0032269	85	0.110
response to wounding	GO:0009611	94	0.107
dephosphorylation	GO:0016311	51	0.106
regulation of phosphorylation	GO:0042325	147	0.106
nucleoside phosphate catabolic process	GO:1901292	110	0.105
multicellular organismal aging	GO:0010259	140	0.105
developmental maturation	GO:0021700	172	0.104
intracellular protein transport	GO:0006886	104	0.104
positive regulation of cell proliferation	GO:0008284	47	0.104
regulation of purine nucleotide catabolic process	GO:0033121	48	0.102
membrane disassembly	GO:0030397	4	0.102
regulation of cytoskeleton organization	GO:0051493	89	0.102
multi organism reproductive behavior	GO:0044705	121	0.101
purine nucleotide catabolic process	GO:0006195	109	0.101
small gtpase mediated signal transduction	GO:0007264	88	0.101	Human
neuroblast fate commitment	GO:0014017	19	0.097
regulation of ubiquitin protein ligase activity involved in mitotic cell cycle	GO:0051439	2	0.097
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.096
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.095
regionalization	GO:0003002	416	0.093
regulation of cellular protein catabolic process	GO:1903362	44	0.093
larval development	GO:0002164	104	0.092
cytoskeleton dependent cytokinesis	GO:0061640	81	0.092
forebrain development	GO:0030900	2	0.092
brain development	GO:0007420	120	0.091
regulation of establishment of protein localization	GO:0070201	61	0.091
axis specification	GO:0009798	167	0.090
regulation of chromosome segregation	GO:0051983	32	0.090
reproductive behavior	GO:0019098	122	0.090
purine nucleotide metabolic process	GO:0006163	146	0.089
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.089
regulation of locomotion	GO:0040012	42	0.087
purine ribonucleoside metabolic process	GO:0046128	127	0.084
carboxylic acid metabolic process	GO:0019752	92	0.084
oocyte anterior posterior axis specification	GO:0007314	72	0.083
renal tubule development	GO:0061326	64	0.083
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.083
epithelial cell differentiation	GO:0030855	322	0.083
camera type eye development	GO:0043010	4	0.083
germ line stem cell division	GO:0042078	25	0.082
nucleoside triphosphate metabolic process	GO:0009141	120	0.081
regulation of cellular protein metabolic process	GO:0032268	243	0.081
transcription from rna polymerase ii promoter	GO:0006366	368	0.080
embryonic hindgut morphogenesis	GO:0048619	48	0.079
positive regulation of cell cycle process	GO:0090068	28	0.079
immune response	GO:0006955	246	0.079
nucleoside phosphate metabolic process	GO:0006753	162	0.078
cell junction organization	GO:0034330	57	0.078
synaptonemal complex organization	GO:0070193	5	0.076
cellular nitrogen compound catabolic process	GO:0044270	165	0.075
regulation of hydrolase activity	GO:0051336	97	0.075
protein transport	GO:0015031	155	0.075
carbohydrate derivative catabolic process	GO:1901136	118	0.075
neuroblast differentiation	GO:0014016	29	0.075
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.074
heterocycle catabolic process	GO:0046700	166	0.074
telencephalon development	GO:0021537	2	0.073
regulation of protein catabolic process	GO:0042176	55	0.073
regulation of protein modification process	GO:0031399	112	0.072
regulation of dna metabolic process	GO:0051052	34	0.071
negative regulation of organelle organization	GO:0010639	56	0.071
spindle assembly involved in mitosis	GO:0090307	50	0.071
glial cell development	GO:0021782	27	0.071
positive regulation of proteolysis	GO:0045862	52	0.070
positive regulation of nucleotide catabolic process	GO:0030813	46	0.070
muscle organ development	GO:0007517	127	0.070
cell projection assembly	GO:0030031	94	0.070
germ line cyst formation	GO:0048134	44	0.069
maintenance of protein location	GO:0045185	28	0.069
negative regulation of cell division	GO:0051782	17	0.068
negative regulation of cell cycle phase transition	GO:1901988	103	0.068
response to radiation	GO:0009314	155	0.068
malpighian tubule morphogenesis	GO:0007443	44	0.067
regulation of dendrite development	GO:0050773	37	0.067
phagocytosis	GO:0006909	215	0.067
anterior posterior pattern specification	GO:0009952	136	0.066
positive regulation of catalytic activity	GO:0043085	118	0.066
ras protein signal transduction	GO:0007265	88	0.066	Human
female germ line cyst formation	GO:0048135	42	0.066
cilium organization	GO:0044782	41	0.066
ribonucleotide metabolic process	GO:0009259	145	0.065
nucleobase containing compound catabolic process	GO:0034655	165	0.064
negative regulation of protein metabolic process	GO:0051248	85	0.064
regulation of intracellular signal transduction	GO:1902531	236	0.063
learning	GO:0007612	75	0.062
asymmetric stem cell division	GO:0098722	49	0.062
regulation of purine nucleotide metabolic process	GO:1900542	62	0.061
ribonucleotide catabolic process	GO:0009261	109	0.061
regulation of nucleocytoplasmic transport	GO:0046822	35	0.061
single organism intracellular transport	GO:1902582	207	0.060
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.060
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.059
purine containing compound catabolic process	GO:0072523	112	0.059
endocytosis	GO:0006897	310	0.058
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.057
pole cell formation	GO:0007279	19	0.057
regulation of cytoplasmic transport	GO:1903649	47	0.057
purine ribonucleotide metabolic process	GO:0009150	145	0.056
purine ribonucleotide catabolic process	GO:0009154	109	0.056
positive regulation of cellular component biogenesis	GO:0044089	80	0.055
meiotic g2 mi transition	GO:0008315	3	0.053
gtp metabolic process	GO:0046039	72	0.052
nucleotide metabolic process	GO:0009117	161	0.052
wnt signaling pathway	GO:0016055	98	0.052
protein complex assembly	GO:0006461	200	0.051
meiotic spindle organization	GO:0000212	36	0.051
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.051
lipid metabolic process	GO:0006629	121	0.051
female meiosis i	GO:0007144	8	0.051
carbohydrate derivative metabolic process	GO:1901135	217	0.051
cellularization	GO:0007349	90	0.050
ribose phosphate metabolic process	GO:0019693	145	0.050
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.050
protein dephosphorylation	GO:0006470	27	0.049
embryonic digestive tract development	GO:0048566	5	0.049
genital disc development	GO:0035215	44	0.049
cell cell junction organization	GO:0045216	55	0.049
protein catabolic process	GO:0030163	101	0.049
cytokinetic cell separation	GO:0000920	1	0.049
positive regulation of protein modification process	GO:0031401	58	0.049
regulation of sister chromatid cohesion	GO:0007063	2	0.048
germarium derived egg chamber formation	GO:0007293	101	0.048
protein ubiquitination	GO:0016567	70	0.046
axon choice point recognition	GO:0016198	26	0.046
negative regulation of multicellular organismal process	GO:0051241	142	0.046
negative regulation of rna metabolic process	GO:0051253	251	0.046
regulation of mitotic spindle organization	GO:0060236	9	0.046
organic substance transport	GO:0071702	257	0.046
regulation of transport	GO:0051049	181	0.045
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.045
hemopoiesis	GO:0030097	46	0.045
negative regulation of chromosome segregation	GO:0051985	14	0.045
lipid storage	GO:0019915	38	0.045
single organism behavior	GO:0044708	391	0.045
positive regulation of developmental growth	GO:0048639	62	0.045
anterior posterior axis specification	GO:0009948	109	0.045
regulation of behavior	GO:0050795	75	0.045
organonitrogen compound catabolic process	GO:1901565	128	0.045
male meiosis	GO:0007140	52	0.044
stem cell maintenance	GO:0019827	67	0.044
negative regulation of cell death	GO:0060548	81	0.044
body morphogenesis	GO:0010171	2	0.044
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.044
positive regulation of cell communication	GO:0010647	250	0.044
negative regulation of cellular biosynthetic process	GO:0031327	277	0.044
regulation of intracellular transport	GO:0032386	64	0.044
organophosphate catabolic process	GO:0046434	112	0.044
negative regulation of catalytic activity	GO:0043086	42	0.043
regulation of neuron projection development	GO:0010975	69	0.043
aromatic compound catabolic process	GO:0019439	166	0.043
gastrulation with mouth forming first	GO:0001703	36	0.042
pole plasm oskar mrna localization	GO:0045451	46	0.042
endomembrane system organization	GO:0010256	119	0.042
negative regulation of mitotic sister chromatid segregation	GO:0033048	13	0.041
maintenance of protein location in cell	GO:0032507	26	0.041
oxidation reduction process	GO:0055114	123	0.041
regulation of cellular component size	GO:0032535	98	0.041
chorion containing eggshell formation	GO:0007304	105	0.040
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.040
meiotic cytokinesis	GO:0033206	33	0.040
negative regulation of cell development	GO:0010721	62	0.040
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.039
behavioral response to starvation	GO:0042595	6	0.038
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.038
regulation of kinase activity	GO:0043549	53	0.038
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.038
regulation of r7 cell differentiation	GO:0045676	15	0.038
cellular macromolecule localization	GO:0070727	220	0.038
dna replication	GO:0006260	48	0.038
nuclear transport	GO:0051169	72	0.037
protein polymerization	GO:0051258	42	0.037
genitalia development	GO:0048806	26	0.037	Worm
negative regulation of metaphase anaphase transition of cell cycle	GO:1902100	13	0.036
proteasomal protein catabolic process	GO:0010498	59	0.036
negative regulation of rna biosynthetic process	GO:1902679	240	0.036
regulation of nucleotide catabolic process	GO:0030811	48	0.036
negative regulation of sister chromatid segregation	GO:0033046	13	0.035
posttranscriptional regulation of gene expression	GO:0010608	145	0.034
cilium assembly	GO:0042384	38	0.034
secretion by cell	GO:0032940	101	0.034
central nervous system neuron differentiation	GO:0021953	8	0.033
nucleobase containing small molecule metabolic process	GO:0055086	174	0.033
negative regulation of protein processing	GO:0010955	31	0.033
negative regulation of signaling	GO:0023057	219	0.032
protein modification by small protein conjugation	GO:0032446	79	0.032
hindgut morphogenesis	GO:0007442	58	0.032
ovulation	GO:0030728	4	0.032
mitotic spindle stabilization	GO:0043148	6	0.032
regulation of meiotic cell cycle	GO:0051445	9	0.031
cardiocyte differentiation	GO:0035051	29	0.031
positive regulation of cell development	GO:0010720	61	0.031
negative regulation of protein phosphorylation	GO:0001933	17	0.031
positive regulation of nervous system development	GO:0051962	69	0.031
cell aging	GO:0007569	2	0.031
embryonic axis specification	GO:0000578	107	0.031
negative regulation of protein modification process	GO:0031400	29	0.031
stem cell fate commitment	GO:0048865	25	0.030
response to organic cyclic compound	GO:0014070	89	0.030
positive regulation of signaling	GO:0023056	243	0.030
adult behavior	GO:0030534	137	0.030
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	13	0.030
positive regulation of r7 cell differentiation	GO:0045678	7	0.030
negative regulation of proteolysis	GO:0045861	31	0.030
regulation of epithelial cell migration	GO:0010632	12	0.030
cilium morphogenesis	GO:0060271	39	0.029
head involution	GO:0008258	35	0.029
histoblast morphogenesis	GO:0007488	9	0.029
positive regulation of cell cycle phase transition	GO:1901989	20	0.029
negative regulation of mitotic metaphase anaphase transition	GO:0045841	13	0.029
positive regulation of protein kinase activity	GO:0045860	25	0.029
regulation of cell size	GO:0008361	63	0.028
actin filament based process	GO:0030029	220	0.028

CycA disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
gastrointestinal system cancer	DOID:3119	0.029
colorectal cancer	DOID:9256	0.029
organ system cancer	DOID:0050686	0.029
intestinal cancer	DOID:10155	0.029
disease of cellular proliferation	DOID:14566	0.029
large intestine cancer	DOID:5672	0.029
cancer	DOID:162	0.029

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