Drosophila melanogaster

53 known processes

rad50 (Dmel_CG6339)

CG6339 gene product from transcript CG6339-RD

(Aliases: RAD50,CG6339,Dmel\CG6339,Rad50,6339,Dmrad50)

rad50 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
telomere cappingGO:0016233111.000
telomere maintenanceGO:0000723210.999
telomere organizationGO:0032200210.999
dna repairGO:0006281540.999
double strand break repair via synthesis dependent strand annealingGO:004500360.996
dna metabolic processGO:00062592270.990
meiotic nuclear divisionGO:00071261510.968
Worm
recombinational repairGO:0000725130.968
cellular response to dna damage stimulusGO:00069742230.967
mitotic dna damage checkpointGO:0044773740.948
double strand break repairGO:0006302260.936
double strand break repair via homologous recombinationGO:0000724130.905
dna double strand break processingGO:000072930.900
dna conformation changeGO:00711031050.887
Human
dna recombinationGO:0006310320.882
dna damage checkpointGO:0000077780.876
chromosome organizationGO:00512763600.851
mitotic cell cycle checkpointGO:0007093880.839
response to radiationGO:00093141550.809
chromosome segregationGO:00070591570.790
Worm
meiotic cell cycleGO:00513211710.751
Worm
dna replicationGO:0006260480.732
Human
g2 dna damage checkpointGO:0031572690.725
cell cycle checkpointGO:0000075950.713
regulation of mitotic cell cycle phase transitionGO:19019901300.708
mitotic g2 m transition checkpointGO:0044818700.677
postreplication repairGO:000630120.666
dna geometric changeGO:0032392160.659
Human
translesion synthesisGO:001998520.658
non recombinational repairGO:000072670.628
organic cyclic compound catabolic processGO:19013611680.601
Human
double strand break repair via nonhomologous end joiningGO:000630350.589
negative regulation of cell cycle g2 m phase transitionGO:190275080.559
embryo development ending in birth or egg hatchingGO:00097921520.556
Worm
organic substance catabolic processGO:19015753080.521
Human
mitotic dna integrity checkpointGO:0044774750.513
dna integrity checkpointGO:0031570810.506
dna amplificationGO:0006277110.498
organelle fissionGO:00482853400.487
Worm
mitotic cell cycle phase transitionGO:00447721380.486
mitotic g2 dna damage checkpointGO:0007095690.484
regulation of cell cycle phase transitionGO:19019871300.480
response to light stimulusGO:00094161240.471
response to uvGO:0009411240.462
cellular response to abiotic stimulusGO:0071214580.458
catabolic processGO:00090564090.457
Human
homeostatic processGO:00425921990.457
anatomical structure homeostasisGO:0060249970.454
response to caffeineGO:0031000120.432
negative regulation of mitotic cell cycle phase transitionGO:19019911030.431
negative regulation of cell cycle phase transitionGO:19019881030.430
signal transduction in response to dna damageGO:004277030.429
mitotic sister chromatid segregationGO:0000070870.418
centrosome cycleGO:00070981370.417
cellular catabolic processGO:00442483720.416
Human
positive regulation of macromolecule metabolic processGO:00106044050.414
Human
sister chromatid segregationGO:0000819920.396
response to ionizing radiationGO:0010212320.386
negative regulation of cell cycleGO:00457861160.308
mitotic spindle organizationGO:00070522200.301
dna duplex unwindingGO:0032508160.299
Human
regulation of mitotic cell cycleGO:00073461900.291
nucleotide excision repairGO:000628980.285
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630110.281
single organism catabolic processGO:00447122280.280
Human
programmed cell deathGO:00125012570.263
Worm
dna synthesis involved in dna repairGO:000073150.247
regulation of phosphate metabolic processGO:00192202100.235
Human
dna biosynthetic processGO:0071897240.231
small molecule metabolic processGO:00442813050.224
Human
cell cycle phase transitionGO:00447701400.212
response to alkaloidGO:0043279260.211
regulation of cell cycleGO:00517262910.210
regulation of cell cycle processGO:00105641810.206
negative regulation of nitrogen compound metabolic processGO:00511722650.193
mitotic nuclear divisionGO:00070672130.191
organonitrogen compound metabolic processGO:19015643180.191
Human
negative regulation of cell cycle processGO:00109481090.187
eggshell chorion gene amplificationGO:000730790.187
meiosis iGO:0007127590.182
purine ribonucleoside monophosphate metabolic processGO:0009167500.180
Human
cellular response to gamma radiationGO:0071480100.176
heterocycle catabolic processGO:00467001660.176
Human
nucleobase containing compound catabolic processGO:00346551650.171
Human
negative regulation of biosynthetic processGO:00098902770.163
organophosphate metabolic processGO:00196371950.163
Human
reciprocal meiotic recombinationGO:0007131190.161
response to abiotic stimulusGO:00096283410.160
regulation of gene expression epigeneticGO:00400291280.148
deathGO:00162652840.147
Worm
negative regulation of nucleobase containing compound metabolic processGO:00459342610.146
response to organonitrogen compoundGO:0010243750.145
regulation of response to dna damage stimulusGO:2001020230.144
negative regulation of mitotic cell cycleGO:00459301090.140
tissue deathGO:00162711020.137
cellular macromolecule catabolic processGO:00442651360.131
Human
aromatic compound catabolic processGO:00194391660.130
Human
vesicle mediated transportGO:00161923810.129
sister chromatid cohesionGO:0007062180.129
ribose phosphate metabolic processGO:00196931450.129
Human
immune responseGO:00069552460.129
macromolecule catabolic processGO:00090571610.124
Human
cellular response to ionizing radiationGO:0071479150.124
cell deathGO:00082192790.121
Worm
dna dependent dna replicationGO:0006261170.121
regulation of catalytic activityGO:00507901850.117
Human
purine nucleoside catabolic processGO:00061521120.117
Human
immune system processGO:00023763470.115
cellular response to radiationGO:0071478520.111
mitotic cell cycle embryonicGO:0045448380.110
chromosome condensationGO:0030261410.110
regulation of dna repairGO:000628250.109
nuclear divisionGO:00002803320.106
Worm
regulation of protein metabolic processGO:00512462560.106
Human
mitotic sister chromatid separationGO:0051306300.104
female meiotic divisionGO:0007143700.101
negative regulation of dna dependent dna replicationGO:200010420.100
meiotic cell cycle processGO:19030461320.099
Worm
positive regulation of gene expressionGO:00106282900.098
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.092
organelle localizationGO:00516401480.089
ribonucleoside metabolic processGO:00091191270.084
Human
nucleoside triphosphate catabolic processGO:00091431080.083
Human
ribonucleotide metabolic processGO:00092591450.082
Human
nucleobase containing small molecule metabolic processGO:00550861740.081
Human
telomere maintenance via recombinationGO:000072210.079
positive regulation of proteolysisGO:0045862520.078
cell cycle dna replicationGO:0044786230.076
axonogenesisGO:00074092900.076
response to organic cyclic compoundGO:0014070890.074
cellular nitrogen compound catabolic processGO:00442701650.074
Human
single organism biosynthetic processGO:00447112060.071
Human
positive regulation of nitrogen compound metabolic processGO:00511733540.071
carbohydrate derivative metabolic processGO:19011352170.068
Human
chromatin silencingGO:0006342760.067
mitotic sister chromatid cohesionGO:000706460.067
purine ribonucleoside metabolic processGO:00461281270.065
Human
purine nucleoside metabolic processGO:00422781270.064
Human
positive regulation of rna biosynthetic processGO:19026802660.064
regulation of phosphorus metabolic processGO:00511742100.063
Human
centrosome duplicationGO:00512981210.061
ribonucleoside monophosphate catabolic processGO:0009158390.060
Human
positive regulation of macromolecule biosynthetic processGO:00105572830.060
embryonic development via the syncytial blastodermGO:00017001480.058
ribonucleoside monophosphate metabolic processGO:0009161510.058
Human
negative regulation of cellular metabolic processGO:00313243820.056
positive regulation of cellular biosynthetic processGO:00313283160.055
nucleoside phosphate metabolic processGO:00067531620.054
Human
purine ribonucleoside triphosphate catabolic processGO:00092071080.053
Human
positive regulation of molecular functionGO:00440931360.052
Human
protein phosphorylationGO:00064681690.051
Human
organophosphate catabolic processGO:00464341120.051
Human
purine nucleoside monophosphate catabolic processGO:0009128380.051
Human
regulation of hydrolase activityGO:0051336970.049
ribonucleoside catabolic processGO:00424541120.049
Human
regulation of kinase activityGO:0043549530.048
Human
organic substance transportGO:00717022570.047
agingGO:00075681430.047
regulation of molecular functionGO:00650092170.046
Human
ribonucleoside triphosphate metabolic processGO:00091991190.045
Human
regulation of organelle organizationGO:00330431960.045
ribonucleoside triphosphate catabolic processGO:00092031080.045
Human
response to purine containing compoundGO:0014074120.044
glycosyl compound metabolic processGO:19016571270.044
Human
response to organic substanceGO:00100332840.044
regulation of cellular protein metabolic processGO:00322682430.044
Human
purine nucleoside triphosphate metabolic processGO:00091441190.044
Human
reciprocal dna recombinationGO:0035825190.044
appendage developmentGO:00487364010.043
negative regulation of dna endoreduplicationGO:003287620.042
nucleoside phosphate catabolic processGO:19012921100.042
Human
regulation of intracellular signal transductionGO:19025312360.042
intracellular signal transductionGO:00355563000.042
organelle assemblyGO:00709251980.041
oocyte fate determinationGO:0030716270.041
centrosome organizationGO:00512971630.041
nucleoside monophosphate metabolic processGO:0009123520.040
Human
intracellular transportGO:00469072280.040
purine ribonucleoside catabolic processGO:00461301120.040
Human
organonitrogen compound catabolic processGO:19015651280.039
Human
nucleoside monophosphate catabolic processGO:0009125390.039
Human
regulation of chromosome organizationGO:0033044640.039
positive regulation of catalytic activityGO:00430851180.039
Human
cell divisionGO:00513012480.039
purine ribonucleotide catabolic processGO:00091541090.038
Human
response to x rayGO:001016580.038
photoreceptor cell developmentGO:0042461960.038
salivary gland histolysisGO:0035070880.038
response to endogenous stimulusGO:00097191190.038
nucleotide catabolic processGO:00091661090.037
Human
positive regulation of response to stimulusGO:00485843230.036
regulation of protein phosphorylationGO:0001932640.036
Human
dna endoreduplicationGO:0042023220.036
purine containing compound catabolic processGO:00725231120.036
Human
purine nucleotide metabolic processGO:00061631460.035
Human
negative regulation of dna metabolic processGO:0051053120.035
posttranscriptional gene silencingGO:0016441460.035
regulation of double strand break repairGO:200077930.035
cellular response to chemical stimulusGO:00708871990.034
spindle organizationGO:00070512530.034
imaginal disc derived appendage morphogenesisGO:00351143950.034
regulation of transcription from rna polymerase ii promoterGO:00063573780.034
regulation of catabolic processGO:00098941700.034
photoreceptor cell differentiationGO:00465301700.034
regulation of cytoskeleton organizationGO:0051493890.033
cellular response to organic cyclic compoundGO:0071407320.033
nucleoside metabolic processGO:00091161270.033
Human
single organism cellular localizationGO:19025801800.032
cellular protein modification processGO:00064644380.032
Human
regulation of response to stressGO:00801342000.031
chromosome separationGO:0051304420.030
purine ribonucleoside triphosphate metabolic processGO:00092051190.029
Human
modification dependent macromolecule catabolic processGO:0043632790.029
meiotic chromosome segregationGO:0045132590.029
Worm
positive regulation of nucleic acid templated transcriptionGO:19035082660.029
nucleus localizationGO:0051647340.029
karyosome formationGO:0030717220.028
cell fate specificationGO:0001708710.028
purine nucleotide catabolic processGO:00061951090.027
Human
protein maturationGO:0051604710.027
positive regulation of signalingGO:00230562430.027
establishment of nucleus localizationGO:0040023260.027
regulation of cellular catabolic processGO:00313291570.027
regulation of dna recombinationGO:000001840.026
Human
purine ribonucleoside monophosphate catabolic processGO:0009169380.026
Human
nuclear migrationGO:0007097200.026
regulation of cell deathGO:00109411730.026
cellular response to organic substanceGO:00713101320.026
neuron projection guidanceGO:00974852410.025
purine nucleoside triphosphate catabolic processGO:00091461080.025
Human
positive regulation of phosphorus metabolic processGO:00105621390.025
Human
establishment of localization in cellGO:00516494020.025
protein modification processGO:00362114380.024
Human
negative regulation of cellular biosynthetic processGO:00313272770.024
salivary gland cell autophagic cell deathGO:0035071830.024
compound eye morphogenesisGO:00017452490.024
compound eye developmentGO:00487493070.024
dendrite morphogenesisGO:00488131990.023
innate immune responseGO:00450871440.023
atp metabolic processGO:0046034490.023
Human
nucleotide metabolic processGO:00091171610.023
Human
cell cell signaling involved in cell fate commitmentGO:00451682100.023
negative regulation of organelle organizationGO:0010639560.022
regulation of response to biotic stimulusGO:0002831630.022
regulation of neurogenesisGO:00507671580.022
apoptotic processGO:00069151590.022
Worm
salivary gland developmentGO:00074311620.022
histolysisGO:00075591020.022
negative regulation of macromolecule biosynthetic processGO:00105582700.022
response to nitrogen compoundGO:1901698900.022
imaginal disc derived wing morphogenesisGO:00074763370.022
ion transportGO:00068111450.021
negative regulation of microtubule polymerization or depolymerizationGO:0031111210.021
microtubule based movementGO:0007018510.021
reproductive structure developmentGO:0048608740.021
phosphatidylinositol 3 phosphate biosynthetic processGO:003609230.021
response to oxygen containing compoundGO:19017002000.020
rna localizationGO:00064031150.020
dorsal closureGO:0007391790.020
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:007005940.020
response to gamma radiationGO:0010332170.020
regulation of cell divisionGO:0051302720.020
regulation of mitotic metaphase anaphase transitionGO:0030071260.020
histone lysine demethylationGO:007007660.020
positive regulation of nucleobase containing compound metabolic processGO:00459353320.020
dna replication checkpointGO:000007680.020
head involutionGO:0008258350.019
immune response regulating signaling pathwayGO:000276420.019
purine nucleoside monophosphate metabolic processGO:0009126500.019
Human
microtubule organizing center organizationGO:00310231680.019
developmental programmed cell deathGO:00106231380.019
purine ribonucleotide metabolic processGO:00091501450.019
Human
mitotic chromosome condensationGO:0007076220.019
autophagic cell deathGO:0048102830.019
positive regulation of transferase activityGO:0051347260.019
Human
immune response activating signal transductionGO:000275720.019
nucleoside triphosphate metabolic processGO:00091411200.019
Human
histone mrna metabolic processGO:000833480.019
atp catabolic processGO:0006200380.019
Human
transcription from rna polymerase ii promoterGO:00063663680.018
gene silencingGO:00164581380.018
metaphase anaphase transition of mitotic cell cycleGO:0007091280.018
histone h4 k20 methylationGO:003477040.018
regulation of mitosisGO:0007088560.018
negative regulation of g2 m transition of mitotic cell cycleGO:001097280.018
negative regulation of photoreceptor cell differentiationGO:004653380.018
negative regulation of cellular component organizationGO:00511291080.018
appendage morphogenesisGO:00351073970.018
purine containing compound metabolic processGO:00725211550.018
Human
positive regulation of cell communicationGO:00106472500.018
phagocytosisGO:00069092150.018
regulation of protein catabolic processGO:0042176550.018
chromosome organization involved in meiosisGO:0070192100.017
cellular macromolecular complex assemblyGO:00346221530.017
ubiquitin dependent protein catabolic processGO:0006511780.017
chorion containing eggshell formationGO:00073041050.017
regulation of mitotic sister chromatid separationGO:0010965280.017
regulation of mitotic sister chromatid segregationGO:0033047280.017
nuclear dna replicationGO:003326010.017
regulation of protein polymerizationGO:0032271280.017
intra s dna damage checkpointGO:003157320.017
dna packagingGO:0006323910.017
lateral inhibitionGO:00463312060.017
dorsal ventral pattern formationGO:00099531330.017
negative regulation of mitotic sister chromatid separationGO:2000816130.016
positive regulation of phosphate metabolic processGO:00459371390.016
Human
hematopoietic stem cell differentiationGO:006021810.016
meiotic dna double strand break processingGO:000070630.016
axon developmentGO:00615642970.016
positive regulation of hydrolase activityGO:0051345780.016
multi organism behaviorGO:00517051750.016
endocytosisGO:00068973100.016
imaginal disc derived appendage developmentGO:00487373990.015
microtubule depolymerizationGO:0007019250.015
positive regulation of immune responseGO:0050778630.015
dendrite developmentGO:00163582040.015
regionalizationGO:00030024160.015
centriole assemblyGO:0098534240.015
exocrine system developmentGO:00352721620.015
regulation of protein modification processGO:00313991120.015
Human
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.015
oxoacid metabolic processGO:00434361030.015
regulation of meiosisGO:004002030.014
regulation of transferase activityGO:0051338580.014
Human
proteolysis involved in cellular protein catabolic processGO:0051603830.014
protein complex biogenesisGO:00702712010.014
cell proliferationGO:00082832990.014
cell cycle comprising mitosis without cytokinesisGO:0033301250.014
multicellular organismal agingGO:00102591400.014
regulation of gene silencingGO:0060968630.014
positive regulation of biosynthetic processGO:00098913160.014
protein autophosphorylationGO:0046777150.014
Human
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.014
modification dependent protein catabolic processGO:0019941780.014
somatic cell dna recombinationGO:001644410.014
jnk cascadeGO:0007254500.014
regulation of metaphase anaphase transition of cell cycleGO:1902099260.014
establishment of protein localizationGO:00451841630.014
regulation of cellular response to stressGO:0080135890.013
development of primary sexual characteristicsGO:0045137500.013
positive regulation of kinase activityGO:0033674250.013
Human
protein transportGO:00150311550.013
chemotaxisGO:00069352490.013
histone h3 k9 acetylationGO:004397030.013
carboxylic acid metabolic processGO:0019752920.013
sex differentiationGO:0007548810.013
dna catabolic process exonucleolyticGO:000073880.013
ribonucleotide catabolic processGO:00092611090.013
Human
intrinsic apoptotic signaling pathwayGO:0097193160.013
eye photoreceptor cell differentiationGO:00017541450.013
gland developmentGO:00487321910.013
reproductive system developmentGO:0061458740.013
negative regulation of gene expressionGO:00106293870.013
phosphorylationGO:00163102940.013
Human
neurological system processGO:00508773580.012
regulation of nervous system developmentGO:00519602480.012
regulation of dna metabolic processGO:0051052340.012
Human
nucleoside catabolic processGO:00091641120.012
Human
replication fork processingGO:003129700.012
negative regulation of mitotic sister chromatid segregationGO:0033048130.012
growthGO:00400073590.012
regulation of nuclear divisionGO:0051783580.012
centriole replicationGO:0007099240.012
microtubule cytoskeleton organization involved in mitosisGO:1902850520.012
cellular response to oxygen containing compoundGO:1901701790.012
axon guidanceGO:00074112330.012
apoptotic signaling pathwayGO:0097190270.012
salivary gland morphogenesisGO:00074351450.012
g2 m transition of mitotic cell cycleGO:0000086190.012
cellular response to ecdysoneGO:0071390170.012
proteolysisGO:00065081920.011
cation transportGO:00068121100.011
regulation of microtubule depolymerizationGO:0031114240.011
response to fungusGO:0009620500.011
single organism intracellular transportGO:19025822070.011
regulation of chromosome segregationGO:0051983320.011
negative regulation of dna replicationGO:000815670.011
spindle assemblyGO:0051225800.011
positive regulation of protein modification processGO:0031401580.011
Human
regulation of cellular protein catabolic processGO:1903362440.011
membrane organizationGO:00610241120.011
regulation of multicellular organismal developmentGO:20000264140.011
protein catabolic processGO:00301631010.011
microtubule based transportGO:0010970420.011
chromatin organizationGO:00063252070.010
regulation of dna replicationGO:0006275130.010
negative regulation of catalytic activityGO:0043086420.010
regulation of stress activated mapk cascadeGO:0032872410.010
regulation of centrosome cycleGO:004660570.010
secretionGO:00469031090.010
regulation of phosphatidylinositol 3 kinase activityGO:004355120.010
glycosyl compound catabolic processGO:19016581120.010
Human
cellular macromolecule localizationGO:00707272200.010
regulation of cellular ketone metabolic processGO:001056530.010
macromolecular complex assemblyGO:00650032560.010
negative regulation of nucleic acid templated transcriptionGO:19035072400.010
positive regulation of phosphorylationGO:0042327870.010
Human
pole cell migrationGO:0007280130.010
regulation of phosphorylationGO:00423251470.010
Human
regulation of sister chromatid segregationGO:0033045280.010
positive regulation of mitotic cell cycleGO:0045931340.010

rad50 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
thoracic cancerDOID:509300.379
organ system cancerDOID:005068600.379
disease of cellular proliferationDOID:1456600.379
cancerDOID:16200.379
breast cancerDOID:161200.021
connective tissue cancerDOID:20100.018
musculoskeletal system cancerDOID:006010000.018