IMP: Integrative Multi-species Prediction

Drosophila melanogaster

132 known processes

Bx (Dmel_CG6500)

Beadex

(Aliases: Bd,hdp-a,Ptd,mgg,dlmo,Dmel\CG6500,DLMO,Lmo,Dlmo,CG6500,hdp,fliH,Rho,LMO,dLmo,beadex/dLMO,mgt,hld,dLMO,dttg)

Entrez: 32846
FLYBASE: FBgn0000242
UniProtKB: M9PI02
UniProtKB: M9PHX4
UniProtKB: O77284
UniProtKB: Q8IQX7

Process Predictions
Disease Predictions

Bx biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
imaginal disc derived appendage development	GO:0048737	399	0.949
appendage development	GO:0048736	401	0.896
appendage morphogenesis	GO:0035107	397	0.853
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.821	Human Mouse
imaginal disc derived wing morphogenesis	GO:0007476	337	0.816
regionalization	GO:0003002	416	0.704
post embryonic appendage morphogenesis	GO:0035120	385	0.698
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.535	Mouse
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.496
leg disc development	GO:0035218	92	0.467
positive regulation of macromolecule metabolic process	GO:0010604	405	0.437
epithelial cell differentiation	GO:0030855	322	0.376
multi organism behavior	GO:0051705	175	0.371
epithelial tube morphogenesis	GO:0060562	88	0.350
positive regulation of cellular biosynthetic process	GO:0031328	316	0.349
branching morphogenesis of an epithelial tube	GO:0048754	45	0.311
imaginal disc derived leg morphogenesis	GO:0007480	80	0.306
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.298
growth	GO:0040007	359	0.271
negative regulation of cellular metabolic process	GO:0031324	382	0.252	Human Mouse
immune system process	GO:0002376	347	0.246
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.246	Human Mouse
protein modification process	GO:0036211	438	0.243
single organism behavior	GO:0044708	391	0.227
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.219	Mouse
positive regulation of gene expression	GO:0010628	290	0.207
wing disc morphogenesis	GO:0007472	344	0.204
regulation of multicellular organismal development	GO:2000026	414	0.192
negative regulation of biosynthetic process	GO:0009890	277	0.185	Mouse
developmental growth	GO:0048589	280	0.177
brain development	GO:0007420	120	0.167
striated muscle cell differentiation	GO:0051146	90	0.165
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.162
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.152	Mouse
negative regulation of cell communication	GO:0010648	223	0.143	Human
morphogenesis of an epithelium	GO:0002009	276	0.135
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.135	Mouse
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.128	Mouse
eye development	GO:0001654	323	0.128
aging	GO:0007568	143	0.127
regulation of cell differentiation	GO:0045595	302	0.124	Human
aggressive behavior	GO:0002118	63	0.109
transcription from rna polymerase ii promoter	GO:0006366	368	0.107	Human Mouse
wing disc pattern formation	GO:0035222	66	0.105
skin development	GO:0043588	65	0.099
striated muscle cell development	GO:0055002	50	0.098
programmed cell death	GO:0012501	257	0.095
imaginal disc pattern formation	GO:0007447	91	0.094
negative regulation of rna metabolic process	GO:0051253	251	0.093	Mouse
organonitrogen compound metabolic process	GO:1901564	318	0.092
regulation of nervous system development	GO:0051960	248	0.090
regulation of growth	GO:0040008	233	0.085
humoral immune response	GO:0006959	117	0.085
regulation of circadian rhythm	GO:0042752	49	0.084
gland development	GO:0048732	191	0.083
regulation of cell cycle	GO:0051726	291	0.079
organic acid metabolic process	GO:0006082	103	0.077
epithelial cell development	GO:0002064	274	0.076
negative regulation of cellular biosynthetic process	GO:0031327	277	0.074	Mouse
cellular protein modification process	GO:0006464	438	0.072
regulation of anatomical structure morphogenesis	GO:0022603	242	0.072
carboxylic acid metabolic process	GO:0019752	92	0.071
muscle cell differentiation	GO:0042692	103	0.069
cellular amino acid metabolic process	GO:0006520	61	0.069
positive regulation of biosynthetic process	GO:0009891	316	0.068
embryo development ending in birth or egg hatching	GO:0009792	152	0.067
chromosome organization	GO:0051276	360	0.066
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.065
compound eye development	GO:0048749	307	0.064
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.063
death	GO:0016265	284	0.062
immune response	GO:0006955	246	0.058
positive regulation of rna biosynthetic process	GO:1902680	266	0.058
central nervous system development	GO:0007417	201	0.056
intracellular signal transduction	GO:0035556	300	0.056	Human
negative regulation of signaling	GO:0023057	219	0.053	Human
response to organic cyclic compound	GO:0014070	89	0.051
synaptic transmission	GO:0007268	288	0.051
chemosensory behavior	GO:0007635	106	0.050
response to organophosphorus	GO:0046683	2	0.050
organophosphate metabolic process	GO:0019637	195	0.049
regulation of protein modification process	GO:0031399	112	0.049
muscle cell development	GO:0055001	50	0.049
positive regulation of transcription dna templated	GO:0045893	266	0.049
negative regulation of gene expression	GO:0010629	387	0.048	Mouse
chromatin organization	GO:0006325	207	0.047
regulation of secretion	GO:0051046	44	0.046
regulation of molecular function	GO:0065009	217	0.045
regulation of protein metabolic process	GO:0051246	256	0.044
regulation of cell death	GO:0010941	173	0.044
apoptotic process	GO:0006915	159	0.043
head development	GO:0060322	135	0.042
regulation of cellular protein metabolic process	GO:0032268	243	0.042
regulation of response to stress	GO:0080134	200	0.039
establishment of localization in cell	GO:0051649	402	0.039
hematopoietic or lymphoid organ development	GO:0048534	57	0.038
neurological system process	GO:0050877	358	0.038
camera type eye development	GO:0043010	4	0.038
leg disc morphogenesis	GO:0007478	80	0.037
response to abiotic stimulus	GO:0009628	341	0.036
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.036
negative regulation of signal transduction	GO:0009968	206	0.036	Human
segmentation	GO:0035282	207	0.035
regulation of cell proliferation	GO:0042127	163	0.033
oxoacid metabolic process	GO:0043436	103	0.032
endocytosis	GO:0006897	310	0.032
tissue morphogenesis	GO:0048729	297	0.031
epidermis development	GO:0008544	65	0.031
positive regulation of developmental process	GO:0051094	143	0.031	Human
morphogenesis of a branching epithelium	GO:0061138	45	0.030
notch signaling pathway	GO:0007219	120	0.029
purine nucleotide metabolic process	GO:0006163	146	0.029
homeostatic process	GO:0042592	199	0.029
developmental growth involved in morphogenesis	GO:0060560	65	0.029
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.029
positive regulation of protein metabolic process	GO:0051247	128	0.028
positive regulation of catabolic process	GO:0009896	105	0.028
regulation of intracellular protein transport	GO:0033157	46	0.028
anatomical structure homeostasis	GO:0060249	97	0.028
wing disc dorsal ventral pattern formation	GO:0048190	47	0.027
regulation of cell morphogenesis	GO:0022604	163	0.026
biological adhesion	GO:0022610	138	0.026
immune system development	GO:0002520	57	0.026
chaeta development	GO:0022416	97	0.026
regulation of transport	GO:0051049	181	0.026
protein modification by small protein conjugation	GO:0032446	79	0.026
regulation of cellular localization	GO:0060341	136	0.026
ion transport	GO:0006811	145	0.025
histolysis	GO:0007559	102	0.025
sensory organ morphogenesis	GO:0090596	260	0.025
small molecule metabolic process	GO:0044281	305	0.025
response to radiation	GO:0009314	155	0.024
regulation of developmental growth	GO:0048638	174	0.024
cellular response to abiotic stimulus	GO:0071214	58	0.024
muscle tissue development	GO:0060537	30	0.024
epidermal cell differentiation	GO:0009913	51	0.024
cell proliferation	GO:0008283	299	0.023
chaeta morphogenesis	GO:0008407	42	0.023
regulation of membrane potential	GO:0042391	35	0.023
regulation of cellular catabolic process	GO:0031329	157	0.023
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.022
response to extracellular stimulus	GO:0009991	116	0.022
cellular catabolic process	GO:0044248	372	0.022
negative regulation of developmental process	GO:0051093	201	0.022
sleep	GO:0030431	49	0.021
regulation of response to external stimulus	GO:0032101	115	0.021
negative regulation of response to stimulus	GO:0048585	258	0.021	Human
negative regulation of rna biosynthetic process	GO:1902679	240	0.021	Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.021	Mouse
nephron development	GO:0072006	3	0.021
axonogenesis	GO:0007409	290	0.021
nucleoside phosphate metabolic process	GO:0006753	162	0.021
carbohydrate derivative metabolic process	GO:1901135	217	0.021
cardiovascular system development	GO:0072358	82	0.021
protein complex assembly	GO:0006461	200	0.021
positive regulation of response to stimulus	GO:0048584	323	0.020	Human
defense response	GO:0006952	300	0.020
positive regulation of signal transduction	GO:0009967	223	0.020	Human
negative regulation of cellular protein metabolic process	GO:0032269	85	0.020
spinal cord development	GO:0021510	1	0.020
regulation of apoptotic process	GO:0042981	130	0.020
body morphogenesis	GO:0010171	2	0.020
covalent chromatin modification	GO:0016569	106	0.020
positive regulation of cellular catabolic process	GO:0031331	95	0.020
adult behavior	GO:0030534	137	0.019
regulation of transmembrane transport	GO:0034762	27	0.019
negative regulation of molecular function	GO:0044092	51	0.019
response to alkaloid	GO:0043279	26	0.019
hindbrain development	GO:0030902	2	0.019
regulation of catabolic process	GO:0009894	170	0.018
positive regulation of molecular function	GO:0044093	136	0.018
negative regulation of transcription dna templated	GO:0045892	237	0.018	Mouse
regulation of hemocyte proliferation	GO:0035206	37	0.018
regulation of viral genome replication	GO:0045069	4	0.018
cellular ketone metabolic process	GO:0042180	24	0.018
imaginal disc growth	GO:0007446	37	0.018
histone modification	GO:0016570	106	0.017
carbohydrate metabolic process	GO:0005975	82	0.017
single organism catabolic process	GO:0044712	228	0.017
positive regulation of signaling	GO:0023056	243	0.017	Human
membrane depolarization	GO:0051899	4	0.017
cell death	GO:0008219	279	0.017
regulation of phosphatase activity	GO:0010921	3	0.017
ovarian follicle cell development	GO:0030707	248	0.017
response to light stimulus	GO:0009416	124	0.017
ion transmembrane transport	GO:0034220	122	0.017
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.017
hemopoiesis	GO:0030097	46	0.017
peptidyl amino acid modification	GO:0018193	105	0.017
dorsal ventral pattern formation	GO:0009953	133	0.016
chromatin modification	GO:0016568	147	0.016
tissue death	GO:0016271	102	0.016
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
regulation of immune response	GO:0050776	118	0.016
regulation of multicellular organism growth	GO:0040014	40	0.016
striated muscle tissue development	GO:0014706	27	0.016
regulation of cellular amine metabolic process	GO:0033238	3	0.016
circadian rhythm	GO:0007623	105	0.016
single organism carbohydrate metabolic process	GO:0044723	72	0.015
imaginal disc derived wing vein specification	GO:0007474	48	0.015
regulation of secretion by cell	GO:1903530	39	0.015
response to nitrogen compound	GO:1901698	90	0.015
intracellular transport	GO:0046907	228	0.015
mesenchymal cell development	GO:0014031	1	0.015
cellular response to endogenous stimulus	GO:0071495	80	0.015
regulation of phosphate metabolic process	GO:0019220	210	0.014	Human
positive regulation of rna metabolic process	GO:0051254	271	0.014
morphogenesis of a branching structure	GO:0001763	45	0.014
regulation of cellular amino acid metabolic process	GO:0006521	0	0.014
autophagy	GO:0006914	108	0.014
germ line stem cell maintenance	GO:0030718	50	0.014
regulation of organ morphogenesis	GO:2000027	78	0.014
ribonucleotide catabolic process	GO:0009261	109	0.014
organonitrogen compound biosynthetic process	GO:1901566	117	0.014
catabolic process	GO:0009056	409	0.014
response to organic substance	GO:0010033	284	0.014
purine containing compound metabolic process	GO:0072521	155	0.013
positive regulation of viral process	GO:0048524	2	0.013
purine ribonucleotide catabolic process	GO:0009154	109	0.013
chemotaxis	GO:0006935	249	0.013
hippo signaling	GO:0035329	20	0.013
positive regulation of cellular component organization	GO:0051130	156	0.013
skeletal muscle adaptation	GO:0043501	1	0.013
cellular nitrogen compound catabolic process	GO:0044270	165	0.013
organelle fission	GO:0048285	340	0.013
compound eye morphogenesis	GO:0001745	249	0.012
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.012
phosphorylation	GO:0016310	294	0.012	Human
regulation of anatomical structure size	GO:0090066	163	0.012
urogenital system development	GO:0001655	72	0.012
sulfur compound metabolic process	GO:0006790	59	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.011
protein import into nucleus	GO:0006606	51	0.011
cellular macromolecule localization	GO:0070727	220	0.011
canonical wnt signaling pathway	GO:0060070	21	0.011
nephron epithelium development	GO:0072009	3	0.011
regulation of cytoplasmic transport	GO:1903649	47	0.011
muscle tissue morphogenesis	GO:0060415	2	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.010
response to other organism	GO:0051707	293	0.010
regulation of protein transport	GO:0051223	57	0.010
somatic muscle development	GO:0007525	66	0.010
immune response regulating signaling pathway	GO:0002764	2	0.010
cuticle pattern formation	GO:0035017	27	0.010
positive regulation of growth	GO:0045927	75	0.010
establishment of organelle localization	GO:0051656	122	0.010
negative regulation of protein metabolic process	GO:0051248	85	0.010
amine metabolic process	GO:0009308	12	0.010
posttranscriptional regulation of gene expression	GO:0010608	145	0.010
organic substance catabolic process	GO:1901575	308	0.010
ribose phosphate metabolic process	GO:0019693	145	0.010
nucleobase containing small molecule metabolic process	GO:0055086	174	0.010
cardiac muscle cell differentiation	GO:0055007	4	0.010
renal system development	GO:0072001	72	0.010
membrane organization	GO:0061024	112	0.010
regulation of notch signaling pathway	GO:0008593	100	0.010
kidney development	GO:0001822	3	0.010
metal ion transport	GO:0030001	74	0.010

Bx disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	nervous system disease	DOID:863	0	0.019
	disease of anatomical entity	DOID:7	0	0.019

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