IMP: Integrative Multi-species Prediction

Drosophila melanogaster

71 known processes

porin (Dmel_CG6647)

CG6647 gene product from transcript CG6647-RA

(Aliases: l(2)k05123,CG6647,Vdac,POR-1,DmVDAC,DmPorin1,Dmel\CG6647,anon-WO02059370.56,DVDAC,VDAC)

Entrez: 34500
FLYBASE: FBgn0004363
UniProtKB: M9PD75
UniProtKB: Q94920

Process Predictions
Disease Predictions

porin biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
male gamete generation	GO:0048232	201	0.971
nucleoside triphosphate catabolic process	GO:0009143	108	0.857
spermatogenesis	GO:0007283	200	0.836
purine containing compound metabolic process	GO:0072521	155	0.826
spermatid development	GO:0007286	98	0.808
locomotory behavior	GO:0007626	176	0.774
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.743
small molecule metabolic process	GO:0044281	305	0.719
determination of adult lifespan	GO:0008340	137	0.663
spermatid differentiation	GO:0048515	114	0.611
ribonucleotide metabolic process	GO:0009259	145	0.597
organophosphate metabolic process	GO:0019637	195	0.597
purine ribonucleoside metabolic process	GO:0046128	127	0.564
nucleoside triphosphate metabolic process	GO:0009141	120	0.466
meiotic cell cycle process	GO:1903046	132	0.460
single organism behavior	GO:0044708	391	0.459	Mouse
organonitrogen compound metabolic process	GO:1901564	318	0.449
ribose phosphate metabolic process	GO:0019693	145	0.446
embryonic morphogenesis	GO:0048598	206	0.441
vesicle mediated transport	GO:0016192	381	0.410
purine nucleotide metabolic process	GO:0006163	146	0.406
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.401
glycosyl compound metabolic process	GO:1901657	127	0.395
atp metabolic process	GO:0046034	49	0.385
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.381
purine ribonucleotide metabolic process	GO:0009150	145	0.352
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.348
purine nucleoside metabolic process	GO:0042278	127	0.340
transmembrane transport	GO:0055085	139	0.338
larval development	GO:0002164	104	0.326
mitochondrial fusion	GO:0008053	7	0.321
purine ribonucleotide catabolic process	GO:0009154	109	0.317
heterocycle catabolic process	GO:0046700	166	0.313
glycosyl compound catabolic process	GO:1901658	112	0.305
embryo development ending in birth or egg hatching	GO:0009792	152	0.300
organelle assembly	GO:0070925	198	0.299
nucleotide catabolic process	GO:0009166	109	0.296
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.293
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.288
nucleoside metabolic process	GO:0009116	127	0.282
ion transmembrane transport	GO:0034220	122	0.280
cellular catabolic process	GO:0044248	372	0.279
multicellular organismal aging	GO:0010259	140	0.275
response to abiotic stimulus	GO:0009628	341	0.273
electron transport chain	GO:0022900	14	0.264
nucleobase containing compound catabolic process	GO:0034655	165	0.241
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.238
cellular macromolecular complex assembly	GO:0034622	153	0.237
nucleoside monophosphate metabolic process	GO:0009123	52	0.236
nucleoside catabolic process	GO:0009164	112	0.232
nucleoside phosphate catabolic process	GO:1901292	110	0.228
ribonucleoside metabolic process	GO:0009119	127	0.220
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.218
aging	GO:0007568	143	0.204
cation transmembrane transport	GO:0098655	88	0.201
apoptotic process	GO:0006915	159	0.201
adult locomotory behavior	GO:0008344	76	0.197
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.196
single organism membrane fusion	GO:0044801	42	0.190
purine containing compound catabolic process	GO:0072523	112	0.189
response to hydrogen peroxide	GO:0042542	11	0.188
regulation of catabolic process	GO:0009894	170	0.187
intrinsic apoptotic signaling pathway	GO:0097193	16	0.169
positive regulation of response to stimulus	GO:0048584	323	0.164
inorganic ion transmembrane transport	GO:0098660	73	0.161
catabolic process	GO:0009056	409	0.159
lipid metabolic process	GO:0006629	121	0.156
homeostatic process	GO:0042592	199	0.155
phagocytosis	GO:0006909	215	0.152
nucleobase containing small molecule metabolic process	GO:0055086	174	0.152
negative regulation of cellular response to oxidative stress	GO:1900408	1	0.148
cellular response to dna damage stimulus	GO:0006974	223	0.147
actin cytoskeleton organization	GO:0030036	206	0.146
purine ribonucleoside catabolic process	GO:0046130	112	0.145
membrane organization	GO:0061024	112	0.144
atp biosynthetic process	GO:0006754	2	0.142
meiotic cell cycle	GO:0051321	171	0.142
carbohydrate derivative metabolic process	GO:1901135	217	0.135
ion transport	GO:0006811	145	0.135
mitochondrion degradation	GO:0000422	8	0.133
sperm individualization	GO:0007291	48	0.133
intracellular signal transduction	GO:0035556	300	0.125
autophagy	GO:0006914	108	0.122
cation transport	GO:0006812	110	0.121
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.120
regulation of multicellular organismal development	GO:2000026	414	0.119
macromolecular complex assembly	GO:0065003	256	0.117
establishment of localization in cell	GO:0051649	402	0.115
striated muscle cell differentiation	GO:0051146	90	0.111
muscle structure development	GO:0061061	224	0.109
eye morphogenesis	GO:0048592	260	0.106
programmed cell death	GO:0012501	257	0.102
organic substance catabolic process	GO:1901575	308	0.101
organonitrogen compound catabolic process	GO:1901565	128	0.100
endocytosis	GO:0006897	310	0.100
inorganic cation transmembrane transport	GO:0098662	61	0.098
nucleoside phosphate metabolic process	GO:0006753	162	0.098
purine nucleoside catabolic process	GO:0006152	112	0.098
apoptotic signaling pathway	GO:0097190	27	0.097
purine nucleoside monophosphate biosynthetic process	GO:0009127	3	0.096
regulation of cell differentiation	GO:0045595	302	0.095
cellular respiration	GO:0045333	26	0.094
sensory organ morphogenesis	GO:0090596	260	0.093
cellular lipid metabolic process	GO:0044255	83	0.092
death	GO:0016265	284	0.091
purine ribonucleotide biosynthetic process	GO:0009152	28	0.091
response to superoxide	GO:0000303	3	0.090
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.089
nucleotide metabolic process	GO:0009117	161	0.086
single organism catabolic process	GO:0044712	228	0.085
purine ribonucleoside monophosphate biosynthetic process	GO:0009168	3	0.080
carbohydrate derivative catabolic process	GO:1901136	118	0.077
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.077
cellular nitrogen compound catabolic process	GO:0044270	165	0.076
carboxylic acid metabolic process	GO:0019752	92	0.076
muscle cell differentiation	GO:0042692	103	0.075
ribonucleotide catabolic process	GO:0009261	109	0.075
regulation of catalytic activity	GO:0050790	185	0.074
regulation of cellular response to oxidative stress	GO:1900407	4	0.074
negative regulation of response to oxidative stress	GO:1902883	1	0.072
nucleoside biosynthetic process	GO:0009163	3	0.072
oxoacid metabolic process	GO:0043436	103	0.072
organophosphate biosynthetic process	GO:0090407	46	0.072
intracellular transport	GO:0046907	228	0.072
microtubule based transport	GO:0010970	42	0.072
purine nucleoside biosynthetic process	GO:0042451	3	0.071
aromatic compound catabolic process	GO:0019439	166	0.071
organophosphate catabolic process	GO:0046434	112	0.068
actin filament based process	GO:0030029	220	0.066
nucleotide biosynthetic process	GO:0009165	34	0.065
single organism membrane organization	GO:0044802	93	0.064
oxidation reduction process	GO:0055114	123	0.062
neurological system process	GO:0050877	358	0.062	Mouse
organic acid metabolic process	GO:0006082	103	0.061
regulation of phosphorus metabolic process	GO:0051174	210	0.060
glycosyl compound biosynthetic process	GO:1901659	3	0.059
biological adhesion	GO:0022610	138	0.059
cell division	GO:0051301	248	0.058
lipid storage	GO:0019915	38	0.058
age dependent general metabolic decline	GO:0007571	3	0.057
response to oxygen radical	GO:0000305	3	0.055
ribose phosphate biosynthetic process	GO:0046390	28	0.053
proteolysis	GO:0006508	192	0.052
hydrogen ion transmembrane transport	GO:1902600	5	0.052
ribonucleoside monophosphate biosynthetic process	GO:0009156	3	0.052
generation of precursor metabolites and energy	GO:0006091	42	0.052
organic cyclic compound catabolic process	GO:1901361	168	0.051
positive regulation of molecular function	GO:0044093	136	0.051
oxidative phosphorylation	GO:0006119	9	0.050
regulation of response to oxidative stress	GO:1902882	4	0.050
regulation of mitochondrial fission	GO:0090140	7	0.049
positive regulation of phosphorus metabolic process	GO:0010562	139	0.048
zinc ion homeostasis	GO:0055069	6	0.048
ribonucleoside biosynthetic process	GO:0042455	3	0.047
regulation of molecular function	GO:0065009	217	0.047
protein localization	GO:0008104	284	0.047
purine nucleotide catabolic process	GO:0006195	109	0.045
regulation of developmental growth	GO:0048638	174	0.044
atp catabolic process	GO:0006200	38	0.044
ribonucleoside triphosphate biosynthetic process	GO:0009201	2	0.044
cellular protein complex assembly	GO:0043623	71	0.043
cytoskeleton dependent cytokinesis	GO:0061640	81	0.041
positive regulation of cell communication	GO:0010647	250	0.040
response to transition metal nanoparticle	GO:1990267	9	0.040
nucleus organization	GO:0006997	45	0.039
camera type eye development	GO:0043010	4	0.039
microtubule organizing center organization	GO:0031023	168	0.038
negative regulation of multicellular organismal process	GO:0051241	142	0.038
cell death	GO:0008219	279	0.037
cytokinesis	GO:0000910	90	0.037
positive regulation of programmed cell death	GO:0043068	62	0.037
regulation of autophagy	GO:0010506	62	0.037
respiratory electron transport chain	GO:0022904	11	0.036
positive regulation of hydrolase activity	GO:0051345	78	0.036
organonitrogen compound biosynthetic process	GO:1901566	117	0.035
cell motility	GO:0048870	251	0.035
phosphorylation	GO:0016310	294	0.034
mitochondrion organization	GO:0007005	65	0.034
positive regulation of catalytic activity	GO:0043085	118	0.034
purine nucleotide biosynthetic process	GO:0006164	29	0.033
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.033
anatomical structure homeostasis	GO:0060249	97	0.032
embryonic development via the syncytial blastoderm	GO:0001700	148	0.032
purine ribonucleoside biosynthetic process	GO:0046129	3	0.031
maintenance of location	GO:0051235	73	0.031
morphogenesis of an epithelium	GO:0002009	276	0.031
localization of cell	GO:0051674	257	0.030
nucleoside monophosphate catabolic process	GO:0009125	39	0.029
single organism cellular localization	GO:1902580	180	0.029
regulation of phosphate metabolic process	GO:0019220	210	0.029
regulation of mitochondrial fusion	GO:0010635	5	0.029
centrosome organization	GO:0051297	163	0.028
energy derivation by oxidation of organic compounds	GO:0015980	32	0.028
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.028
somatic muscle development	GO:0007525	66	0.027
cellular component assembly involved in morphogenesis	GO:0010927	151	0.027
mitotic nuclear division	GO:0007067	213	0.027
positive regulation of phosphate metabolic process	GO:0045937	139	0.027
positive regulation of apoptotic process	GO:0043065	47	0.026
cellularization	GO:0007349	90	0.026
mitochondrion morphogenesis	GO:0070584	8	0.025
protein complex biogenesis	GO:0070271	201	0.025
nucleoside phosphate biosynthetic process	GO:1901293	34	0.024
ribonucleotide biosynthetic process	GO:0009260	28	0.024
regulation of cell morphogenesis	GO:0022604	163	0.024
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.024
response to metal ion	GO:0010038	23	0.024
establishment or maintenance of cell polarity	GO:0007163	167	0.024
positive regulation of nucleotide metabolic process	GO:0045981	55	0.023
organelle fission	GO:0048285	340	0.023
positive regulation of macromolecule metabolic process	GO:0010604	405	0.023
cell proliferation	GO:0008283	299	0.023
synaptic transmission	GO:0007268	288	0.022	Mouse
regulation of intracellular signal transduction	GO:1902531	236	0.021
single organism biosynthetic process	GO:0044711	206	0.021
purine containing compound biosynthetic process	GO:0072522	30	0.021
adult behavior	GO:0030534	137	0.021
pigmentation	GO:0043473	75	0.021
regulation of nucleotide metabolic process	GO:0006140	62	0.020
organic substance transport	GO:0071702	257	0.020
regulation of apoptotic process	GO:0042981	130	0.020
tissue homeostasis	GO:0001894	36	0.020
embryonic pattern specification	GO:0009880	174	0.019
metal ion homeostasis	GO:0055065	44	0.019
regulation of cell death	GO:0010941	173	0.019
ribonucleoside catabolic process	GO:0042454	112	0.018
regulation of mitochondrial membrane potential	GO:0051881	2	0.018
regulation of anatomical structure morphogenesis	GO:0022603	242	0.018
positive regulation of cell death	GO:0010942	69	0.017
receptor mediated endocytosis	GO:0006898	21	0.017
response to inorganic substance	GO:0010035	44	0.017
regulation of nucleoside metabolic process	GO:0009118	50	0.016
regulation of cellular catabolic process	GO:0031329	157	0.016
regulation of localization	GO:0032879	275	0.016
single organism intracellular transport	GO:1902582	207	0.016
positive regulation of endopeptidase activity	GO:0010950	26	0.016
regulation of response to stress	GO:0080134	200	0.015
actomyosin structure organization	GO:0031032	56	0.015
monovalent inorganic cation transport	GO:0015672	40	0.015
atp synthesis coupled electron transport	GO:0042773	8	0.015
cell maturation	GO:0048469	144	0.015
regulation of programmed cell death	GO:0043067	152	0.015
multicellular organismal homeostasis	GO:0048871	41	0.014
growth	GO:0040007	359	0.014	Zebrafish
regulation of membrane potential	GO:0042391	35	0.014
regulation of necrotic cell death	GO:0010939	1	0.014
regulation of neurogenesis	GO:0050767	158	0.014
chemical homeostasis	GO:0048878	92	0.014
purine ribonucleoside triphosphate biosynthetic process	GO:0009206	2	0.014
central nervous system development	GO:0007417	201	0.014
nucleoside triphosphate biosynthetic process	GO:0009142	2	0.014
purine nucleoside triphosphate biosynthetic process	GO:0009145	2	0.014
regulation of hydrolase activity	GO:0051336	97	0.014
nucleoside monophosphate biosynthetic process	GO:0009124	4	0.013
regulation of apoptotic signaling pathway	GO:2001233	10	0.013
response to ionizing radiation	GO:0010212	32	0.013
embryonic axis specification	GO:0000578	107	0.013
regulation of phagocytosis engulfment	GO:0060099	1	0.013
cellular homeostasis	GO:0019725	80	0.013
nuclear division	GO:0000280	332	0.013
cell migration	GO:0016477	238	0.012
cellular macromolecule localization	GO:0070727	220	0.012
head development	GO:0060322	135	0.012
digestive tract development	GO:0048565	149	0.012
development of primary sexual characteristics	GO:0045137	50	0.012
lipid biosynthetic process	GO:0008610	46	0.012
cellular protein modification process	GO:0006464	438	0.011
small gtpase mediated signal transduction	GO:0007264	88	0.011
membrane fusion	GO:0061025	42	0.011
wound healing	GO:0042060	75	0.011	Zebrafish
regulation of purine nucleotide metabolic process	GO:1900542	62	0.011
neuromuscular synaptic transmission	GO:0007274	67	0.011
ubiquitin dependent protein catabolic process	GO:0006511	78	0.011
retinal cell programmed cell death	GO:0046666	25	0.011
cell aging	GO:0007569	2	0.010
neuromuscular junction development	GO:0007528	149	0.010
lipid localization	GO:0010876	54	0.010
response to radiation	GO:0009314	155	0.010
regulation of cell development	GO:0060284	215	0.010
protein transport	GO:0015031	155	0.010

porin disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	nervous system disease	DOID:863	0	0.024
	disease of anatomical entity	DOID:7	0	0.024

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