IMP: Integrative Multi-species Prediction

Drosophila melanogaster

104 known processes

Vps4 (Dmel_CG6842)

Vacuolar protein sorting 4

(Aliases: CG6842,bcDNA:GH02678,dvps4,Dmel\CG6842,DmBcDNA.GH02678,BcDNA:GH02678,vps4)

Entrez: 32777
FLYBASE: FBgn0027605
UniProtKB: Q9Y162

Process Predictions
Disease Predictions

Vps4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
death	GO:0016265	284	0.413	Worm
response to oxidative stress	GO:0006979	86	0.346
cell death	GO:0008219	279	0.308	Worm
imaginal disc derived appendage development	GO:0048737	399	0.302
cellular catabolic process	GO:0044248	372	0.250
regulation of growth	GO:0040008	233	0.234
vacuolar transport	GO:0007034	13	0.220	Yeast
cell growth	GO:0016049	108	0.217
single organism membrane budding	GO:1902591	2	0.213	Yeast
cytoplasmic transport	GO:0016482	130	0.184	Human Yeast
actin filament based process	GO:0030029	220	0.169
organic substance transport	GO:0071702	257	0.162	Human Mouse
modification dependent macromolecule catabolic process	GO:0043632	79	0.161
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.143
developmental growth	GO:0048589	280	0.129
dna metabolic process	GO:0006259	227	0.125
protein localization	GO:0008104	284	0.118	Yeast
protein transport	GO:0015031	155	0.116
actin cytoskeleton organization	GO:0030036	206	0.108
meiotic nuclear division	GO:0007126	151	0.108
negative regulation of response to stimulus	GO:0048585	258	0.104
vesicle mediated transport	GO:0016192	381	0.100
establishment of protein localization	GO:0045184	163	0.094
small molecule metabolic process	GO:0044281	305	0.091	Human Yeast
organic substance catabolic process	GO:1901575	308	0.087
positive regulation of macromolecule metabolic process	GO:0010604	405	0.083
endosome transport via multivesicular body sorting pathway	GO:0032509	12	0.080	Human Yeast
meiotic chromosome segregation	GO:0045132	59	0.079
single organism intracellular transport	GO:1902582	207	0.078	Human Yeast
programmed cell death	GO:0012501	257	0.076	Worm
establishment of localization in cell	GO:0051649	402	0.076	Human Yeast
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.074
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.073
cellular macromolecule localization	GO:0070727	220	0.073	Yeast
intracellular transport	GO:0046907	228	0.072	Human Yeast
positive regulation of developmental process	GO:0051094	143	0.072
negative regulation of signal transduction	GO:0009968	206	0.064
regulation of erbb signaling pathway	GO:1901184	42	0.063
ubiquitin dependent protein catabolic process	GO:0006511	78	0.063
positive regulation of cellular catabolic process	GO:0031331	95	0.063
response to abiotic stimulus	GO:0009628	341	0.062
single organism membrane organization	GO:0044802	93	0.058
regulation of transport	GO:0051049	181	0.057	Human
axonogenesis	GO:0007409	290	0.057
larval midgut histolysis	GO:0035069	22	0.057
lateral inhibition	GO:0046331	206	0.055
cellular response to chemical stimulus	GO:0070887	199	0.055
membrane organization	GO:0061024	112	0.054
response to other organism	GO:0051707	293	0.053
autophagic vacuole assembly	GO:0000045	2	0.053
regulation of multi organism process	GO:0043900	131	0.053
regulation of synapse structure and activity	GO:0050803	128	0.052
positive regulation of protein metabolic process	GO:0051247	128	0.052
regulation of anatomical structure morphogenesis	GO:0022603	242	0.050
eye morphogenesis	GO:0048592	260	0.049
single organism cellular localization	GO:1902580	180	0.048	Yeast
nucleobase containing small molecule metabolic process	GO:0055086	174	0.047	Human Yeast
cell motility	GO:0048870	251	0.047
nucleoside catabolic process	GO:0009164	112	0.046	Human Yeast
protein targeting	GO:0006605	64	0.046
endocytosis	GO:0006897	310	0.046
growth	GO:0040007	359	0.045
nucleoside phosphate catabolic process	GO:1901292	110	0.045	Human Yeast
cellular macromolecule catabolic process	GO:0044265	136	0.044
secretion by cell	GO:0032940	101	0.043	Human
positive regulation of cellular biosynthetic process	GO:0031328	316	0.043
organonitrogen compound metabolic process	GO:1901564	318	0.043	Human Yeast
regulation of localization	GO:0032879	275	0.042	Human
appendage development	GO:0048736	401	0.042
apoptotic process	GO:0006915	159	0.042	Worm
regulation of synapse organization	GO:0050807	110	0.042
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.041
regulation of cell projection organization	GO:0031344	92	0.041
membrane budding	GO:0006900	4	0.041	Human Yeast
protein phosphorylation	GO:0006468	169	0.040
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.039
regulation of neuron projection development	GO:0010975	69	0.039
molting cycle	GO:0042303	56	0.039	Worm
negative regulation of erbb signaling pathway	GO:1901185	29	0.038
regulation of organelle organization	GO:0033043	196	0.038
cellular response to reactive oxygen species	GO:0034614	14	0.038
cellular response to organic substance	GO:0071310	132	0.038
ribonucleoside metabolic process	GO:0009119	127	0.038	Human Yeast
positive regulation of growth	GO:0045927	75	0.038
regulation of cell development	GO:0060284	215	0.038
spindle organization	GO:0007051	253	0.038
synaptic growth at neuromuscular junction	GO:0051124	119	0.037
regulation of cell differentiation	GO:0045595	302	0.037
embryo development ending in birth or egg hatching	GO:0009792	152	0.036	Worm
negative regulation of cellular biosynthetic process	GO:0031327	277	0.036
aromatic compound catabolic process	GO:0019439	166	0.036	Human Yeast
regulation of intracellular protein transport	GO:0033157	46	0.035
organophosphate metabolic process	GO:0019637	195	0.035	Human Yeast
organelle fission	GO:0048285	340	0.035
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.035
cellular response to external stimulus	GO:0071496	66	0.034
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.034	Human Yeast
taxis	GO:0042330	304	0.034
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.034	Human Yeast
glycosyl compound metabolic process	GO:1901657	127	0.034	Human Yeast
modification dependent protein catabolic process	GO:0019941	78	0.033
meiotic cell cycle process	GO:1903046	132	0.033
nucleotide metabolic process	GO:0009117	161	0.033	Human Yeast
macroautophagy	GO:0016236	42	0.033
chromosome segregation	GO:0007059	157	0.032
regulation of neuron differentiation	GO:0045664	103	0.032
protein modification process	GO:0036211	438	0.032
axon guidance	GO:0007411	233	0.031
carbohydrate derivative catabolic process	GO:1901136	118	0.031	Human Yeast
protein complex assembly	GO:0006461	200	0.031	Yeast
imaginal disc derived wing morphogenesis	GO:0007476	337	0.031
gtp catabolic process	GO:0006184	72	0.031
regulation of cell death	GO:0010941	173	0.031
purine nucleotide catabolic process	GO:0006195	109	0.030	Human Yeast
chromosome organization	GO:0051276	360	0.030
regulation of cellular localization	GO:0060341	136	0.029	Human
cellular protein catabolic process	GO:0044257	83	0.028
cellular protein localization	GO:0034613	160	0.028	Yeast
intracellular protein transport	GO:0006886	104	0.028
heterocycle catabolic process	GO:0046700	166	0.028	Human Yeast
positive regulation of cellular component organization	GO:0051130	156	0.027
regulation of programmed cell death	GO:0043067	152	0.027
negative regulation of biosynthetic process	GO:0009890	277	0.027
autophagy	GO:0006914	108	0.026
response to endoplasmic reticulum stress	GO:0034976	28	0.026
cellular homeostasis	GO:0019725	80	0.026
maintenance of location in cell	GO:0051651	28	0.026	Yeast
regulation of cell cycle	GO:0051726	291	0.026	Human
negative regulation of cellular response to oxidative stress	GO:1900408	1	0.026
developmental programmed cell death	GO:0010623	138	0.026
single organism catabolic process	GO:0044712	228	0.026
chemotaxis	GO:0006935	249	0.026
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.026
muscle structure development	GO:0061061	224	0.025
lipid modification	GO:0030258	24	0.025
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.025
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.025	Human Yeast
establishment of organelle localization	GO:0051656	122	0.025
regulation of cellular protein metabolic process	GO:0032268	243	0.025
regulation of protein metabolic process	GO:0051246	256	0.025
phagocytosis	GO:0006909	215	0.025
regulation of molecular function	GO:0065009	217	0.024
organic hydroxy compound metabolic process	GO:1901615	83	0.024	Yeast
regulation of vesicle mediated transport	GO:0060627	59	0.024	Human
appendage morphogenesis	GO:0035107	397	0.024
purine ribonucleoside metabolic process	GO:0046128	127	0.024	Human Yeast
regulation of epithelial cell proliferation	GO:0050678	4	0.024
regulation of developmental growth	GO:0048638	174	0.024
regulation of apoptotic process	GO:0042981	130	0.024
nucleoside metabolic process	GO:0009116	127	0.024	Human Yeast
eye development	GO:0001654	323	0.024
meiotic cytokinesis	GO:0033206	33	0.023
chemical homeostasis	GO:0048878	92	0.023
immune response regulating signaling pathway	GO:0002764	2	0.023
nucleocytoplasmic transport	GO:0006913	72	0.023
defense response	GO:0006952	300	0.023
determination of adult lifespan	GO:0008340	137	0.023
ribose phosphate metabolic process	GO:0019693	145	0.023	Human Yeast
intracellular signal transduction	GO:0035556	300	0.023
neuromuscular junction development	GO:0007528	149	0.023
positive regulation of cellular protein metabolic process	GO:0032270	118	0.023
response to biotic stimulus	GO:0009607	294	0.022
organic cyclic compound catabolic process	GO:1901361	168	0.022	Human Yeast
regulation of response to stress	GO:0080134	200	0.022
positive regulation of molecular function	GO:0044093	136	0.022
regulation of response to external stimulus	GO:0032101	115	0.022
purine nucleoside catabolic process	GO:0006152	112	0.022	Human Yeast
centrosome organization	GO:0051297	163	0.022
meiotic cell cycle	GO:0051321	171	0.021
nuclear transport	GO:0051169	72	0.021
nucleoside triphosphate metabolic process	GO:0009141	120	0.021	Human Yeast
proteasomal protein catabolic process	GO:0010498	59	0.021
transcription from rna polymerase ii promoter	GO:0006366	368	0.021
positive regulation of multi organism process	GO:0043902	40	0.021	Human
regulation of protein localization	GO:0032880	76	0.021
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.020	Human Yeast
leg disc development	GO:0035218	92	0.020
compound eye development	GO:0048749	307	0.020
synapse organization	GO:0050808	196	0.020
maintenance of location	GO:0051235	73	0.020	Yeast
negative regulation of rna metabolic process	GO:0051253	251	0.020
regulation of cell size	GO:0008361	63	0.020
purine containing compound metabolic process	GO:0072521	155	0.020	Human Yeast
small gtpase mediated signal transduction	GO:0007264	88	0.020
secretion	GO:0046903	109	0.019	Human
striated muscle cell development	GO:0055002	50	0.019
regulation of cellular component size	GO:0032535	98	0.019
response to extracellular stimulus	GO:0009991	116	0.019
ribonucleotide catabolic process	GO:0009261	109	0.019	Human Yeast
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.019	Human Yeast
positive regulation of programmed cell death	GO:0043068	62	0.019
positive regulation of multicellular organismal process	GO:0051240	143	0.019
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.019
regulation of intracellular signal transduction	GO:1902531	236	0.018
positive regulation of cell death	GO:0010942	69	0.018
regulation of locomotion	GO:0040012	42	0.018
regulation of cytoskeleton organization	GO:0051493	89	0.018
regulation of cell morphogenesis	GO:0022604	163	0.018
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.018
regulation of multicellular organismal development	GO:2000026	414	0.018
organelle assembly	GO:0070925	198	0.018
positive regulation of hydrolase activity	GO:0051345	78	0.018
nucleoside triphosphate catabolic process	GO:0009143	108	0.018	Human Yeast
catabolic process	GO:0009056	409	0.018
regulation of nervous system development	GO:0051960	248	0.017
regulation of catalytic activity	GO:0050790	185	0.017
interspecies interaction between organisms	GO:0044419	16	0.017
positive regulation of gene expression	GO:0010628	290	0.017
inorganic ion transmembrane transport	GO:0098660	73	0.017
positive regulation of apoptotic process	GO:0043065	47	0.017
actomyosin structure organization	GO:0031032	56	0.017
purine nucleoside metabolic process	GO:0042278	127	0.017	Human Yeast
tissue morphogenesis	GO:0048729	297	0.017
regulation of hydrolase activity	GO:0051336	97	0.017
positive regulation of catabolic process	GO:0009896	105	0.017
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.016
regulation of phosphatase activity	GO:0010921	3	0.016
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.016
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.016
protein catabolic process	GO:0030163	101	0.016
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.016
positive regulation of phosphate metabolic process	GO:0045937	139	0.016
nucleobase containing compound catabolic process	GO:0034655	165	0.016	Human Yeast
post embryonic appendage morphogenesis	GO:0035120	385	0.016
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.016
inorganic cation transmembrane transport	GO:0098662	61	0.016
phosphatidylinositol mediated signaling	GO:0048015	4	0.016
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
positive regulation of gtpase activity	GO:0043547	43	0.016
immune system process	GO:0002376	347	0.016
scf dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031146	1	0.016
microtubule based movement	GO:0007018	51	0.016
g protein coupled receptor signaling pathway	GO:0007186	136	0.016
single organism behavior	GO:0044708	391	0.016
store operated calcium entry	GO:0002115	3	0.016
phosphorylation	GO:0016310	294	0.015
female meiotic division	GO:0007143	70	0.015
cellular ketone metabolic process	GO:0042180	24	0.015
purine containing compound catabolic process	GO:0072523	112	0.015	Human Yeast
larval midgut cell programmed cell death	GO:0035096	19	0.015
gtp metabolic process	GO:0046039	72	0.015
phospholipid metabolic process	GO:0006644	23	0.015
reproductive behavior	GO:0019098	122	0.015
negative regulation of cellular metabolic process	GO:0031324	382	0.015
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.015
larval development	GO:0002164	104	0.015	Worm
carbohydrate derivative metabolic process	GO:1901135	217	0.015	Human Yeast
negative regulation of cell communication	GO:0010648	223	0.015
chaeta development	GO:0022416	97	0.014
cation transmembrane transport	GO:0098655	88	0.014
protein localization to organelle	GO:0033365	82	0.014	Yeast
localization of cell	GO:0051674	257	0.014
body morphogenesis	GO:0010171	2	0.014
cellular amine metabolic process	GO:0044106	12	0.014
regulation of hemocyte proliferation	GO:0035206	37	0.014
immune response	GO:0006955	246	0.014
spindle assembly	GO:0051225	80	0.014
positive regulation of rna metabolic process	GO:0051254	271	0.014
regulation of cytoplasmic transport	GO:1903649	47	0.014
ameboidal type cell migration	GO:0001667	151	0.014
regulation of response to biotic stimulus	GO:0002831	63	0.014
vesicle organization	GO:0016050	44	0.014	Human Yeast
tissue death	GO:0016271	102	0.013
protein prenylation	GO:0018342	3	0.013
cation transport	GO:0006812	110	0.013	Mouse
response to ionizing radiation	GO:0010212	32	0.013
aging	GO:0007568	143	0.013
regulation of intracellular transport	GO:0032386	64	0.013
regulation of protein transport	GO:0051223	57	0.013
proteolysis	GO:0006508	192	0.013
amine metabolic process	GO:0009308	12	0.013
phospholipase c activating g protein coupled receptor signaling pathway	GO:0007200	10	0.013
anatomical structure homeostasis	GO:0060249	97	0.013
regulation of macroautophagy	GO:0016241	15	0.013
multicellular organismal aging	GO:0010259	140	0.013
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.013
antimicrobial humoral response	GO:0019730	99	0.013
regulation of phosphorylation	GO:0042325	147	0.013
positive regulation of phosphorus metabolic process	GO:0010562	139	0.012
protein secretion	GO:0009306	45	0.012
ras protein signal transduction	GO:0007265	88	0.012
protein kinase b signaling	GO:0043491	1	0.012
regulation of cellular component biogenesis	GO:0044087	201	0.012
positive regulation of cell development	GO:0010720	61	0.012
macromolecule catabolic process	GO:0009057	161	0.012
axon development	GO:0061564	297	0.012
cellular response to starvation	GO:0009267	61	0.012
instar larval development	GO:0002168	55	0.012
erbb signaling pathway	GO:0038127	58	0.012
translation	GO:0006412	69	0.012
negative regulation of signaling	GO:0023057	219	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.012
regulation of cell shape	GO:0008360	113	0.012
response to organic substance	GO:0010033	284	0.012	Human
dna repair	GO:0006281	54	0.012
cell division	GO:0051301	248	0.012	Human
endomembrane system organization	GO:0010256	119	0.012	Mouse
cellular amino acid metabolic process	GO:0006520	61	0.012
cortical actin cytoskeleton organization	GO:0030866	24	0.012
establishment of protein localization to organelle	GO:0072594	62	0.011
regulation of secretion	GO:0051046	44	0.011	Human
regulation of catabolic process	GO:0009894	170	0.011
purine ribonucleoside catabolic process	GO:0046130	112	0.011	Human Yeast
protein targeting to nucleus	GO:0044744	51	0.011
regulation of cellular response to stress	GO:0080135	89	0.011
purine nucleotide metabolic process	GO:0006163	146	0.011	Human Yeast
kidney morphogenesis	GO:0060993	3	0.011
response to light stimulus	GO:0009416	124	0.011
positive regulation of phagocytosis engulfment	GO:0060100	1	0.011
positive regulation of transport	GO:0051050	92	0.011	Human
histone h4 k16 acetylation	GO:0043984	4	0.011
antimicrobial peptide production	GO:0002775	46	0.011
leg disc morphogenesis	GO:0007478	80	0.011
cortical cytoskeleton organization	GO:0030865	29	0.011
positive regulation of rna biosynthetic process	GO:1902680	266	0.011
regulation of meiosis	GO:0040020	3	0.011
epithelial cell development	GO:0002064	274	0.011
phosphatidylinositol phosphorylation	GO:0046854	10	0.011
organonitrogen compound catabolic process	GO:1901565	128	0.011	Human Yeast
negative regulation of gene expression	GO:0010629	387	0.011
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.011
regulation of establishment of protein localization	GO:0070201	61	0.011
regulation of notch signaling pathway	GO:0008593	100	0.011
defense response to other organism	GO:0098542	225	0.011
regulation of transferase activity	GO:0051338	58	0.010
positive regulation of response to external stimulus	GO:0032103	44	0.010
autophagic cell death	GO:0048102	83	0.010
cellular protein modification process	GO:0006464	438	0.010
epithelial cell migration	GO:0010631	148	0.010
guanosine containing compound catabolic process	GO:1901069	74	0.010
organelle localization	GO:0051640	148	0.010
positive regulation of intracellular signal transduction	GO:1902533	116	0.010
positive regulation of autophagy	GO:0010508	21	0.010
neuron projection guidance	GO:0097485	241	0.010

Vps4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.097
disease of anatomical entity	DOID:7	0.097
central nervous system disease	DOID:331	0.019
neurodegenerative disease	DOID:1289	0.015
motor neuron disease	DOID:231	0.015
cancer	DOID:162	0.010
disease of cellular proliferation	DOID:14566	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network