IMP: Integrative Multi-species Prediction

Drosophila melanogaster

83 known processes

mam (Dmel_CG8118)

mastermind

(Aliases: Dmel\CG8118,SR2-4,dMam,l(2)03505,CG8118,l(2)04615,Dm0064,N-2G,Mam,mam(CAG)[[7]])

Entrez: 36555
FLYBASE: FBgn0002643
UniProtKB: P21519

Process Predictions
Disease Predictions

mam biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
motor neuron axon guidance	GO:0008045	58	0.999
negative regulation of transcription dna templated	GO:0045892	237	0.998
neuron projection guidance	GO:0097485	241	0.997
axonogenesis	GO:0007409	290	0.996
neuroblast fate determination	GO:0007400	12	0.989
appendage development	GO:0048736	401	0.987
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.984
positive regulation of macromolecule metabolic process	GO:0010604	405	0.979
negative regulation of biosynthetic process	GO:0009890	277	0.975
eye photoreceptor cell differentiation	GO:0001754	145	0.974
axon guidance	GO:0007411	233	0.969
chemotaxis	GO:0006935	249	0.957
regionalization	GO:0003002	416	0.956
embryonic morphogenesis	GO:0048598	206	0.949
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.948
compound eye morphogenesis	GO:0001745	249	0.948
neuroblast differentiation	GO:0014016	29	0.946
renal system development	GO:0072001	72	0.946
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.941
sensory organ morphogenesis	GO:0090596	260	0.941
imaginal disc derived appendage development	GO:0048737	399	0.940
negative regulation of cellular biosynthetic process	GO:0031327	277	0.939
imaginal disc derived wing morphogenesis	GO:0007476	337	0.932
axon development	GO:0061564	297	0.926
negative regulation of rna biosynthetic process	GO:1902679	240	0.924
appendage morphogenesis	GO:0035107	397	0.922
epithelial cell differentiation	GO:0030855	322	0.916
notch signaling pathway	GO:0007219	120	0.915
stem cell maintenance	GO:0019827	67	0.905
negative regulation of rna metabolic process	GO:0051253	251	0.904
post embryonic appendage morphogenesis	GO:0035120	385	0.901
brain development	GO:0007420	120	0.898
telencephalon development	GO:0021537	2	0.896
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.895
tube development	GO:0035295	244	0.888
neural precursor cell proliferation	GO:0061351	75	0.879
taxis	GO:0042330	304	0.875
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.864
forebrain development	GO:0030900	2	0.863
compound eye development	GO:0048749	307	0.854
cell motility	GO:0048870	251	0.838
positive regulation of neurogenesis	GO:0050769	41	0.837
head development	GO:0060322	135	0.819
dorsal ventral pattern formation	GO:0009953	133	0.818
sensory organ boundary specification	GO:0008052	22	0.813
urogenital system development	GO:0001655	72	0.797
regulation of photoreceptor cell differentiation	GO:0046532	34	0.795
regulation of neuron differentiation	GO:0045664	103	0.788
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.785
stem cell development	GO:0048864	79	0.783
eye development	GO:0001654	323	0.771
positive regulation of transcription dna templated	GO:0045893	266	0.767
neuroblast fate commitment	GO:0014017	19	0.755
cell fate determination	GO:0001709	91	0.746
heart development	GO:0007507	82	0.741
epithelial cell development	GO:0002064	274	0.740
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.729
open tracheal system development	GO:0007424	204	0.721
epidermis development	GO:0008544	65	0.711
regulation of notch signaling pathway	GO:0008593	100	0.710
compound eye photoreceptor fate commitment	GO:0001752	36	0.696
regulation of axon extension involved in axon guidance	GO:0048841	4	0.680
dendrite morphogenesis	GO:0048813	199	0.673
eye photoreceptor cell fate commitment	GO:0042706	37	0.659
lateral inhibition	GO:0046331	206	0.658
regulation of nervous system development	GO:0051960	248	0.653
epithelial cell migration	GO:0010631	148	0.631
positive regulation of nervous system development	GO:0051962	69	0.616
wing disc morphogenesis	GO:0007472	344	0.615
compound eye photoreceptor cell differentiation	GO:0001751	140	0.590
muscle organ development	GO:0007517	127	0.577
dendrite development	GO:0016358	204	0.569
regulation of dendrite morphogenesis	GO:0048814	28	0.553
spinal cord development	GO:0021510	1	0.551
eye morphogenesis	GO:0048592	260	0.539
neuron recognition	GO:0008038	101	0.537
embryonic pattern specification	GO:0009880	174	0.529
r7 cell differentiation	GO:0045466	43	0.505
regulation of cell differentiation	GO:0045595	302	0.492
stem cell fate determination	GO:0048867	15	0.486
tissue migration	GO:0090130	155	0.477
regulation of anatomical structure morphogenesis	GO:0022603	242	0.460
stem cell fate commitment	GO:0048865	25	0.460
retinal ganglion cell axon guidance	GO:0031290	12	0.454
negative regulation of signal transduction	GO:0009968	206	0.452
stem cell differentiation	GO:0048863	117	0.437
negative regulation of cellular metabolic process	GO:0031324	382	0.416
transcription from rna polymerase ii promoter	GO:0006366	368	0.409
regulation of dendrite development	GO:0050773	37	0.396
compound eye photoreceptor development	GO:0042051	78	0.396
cell proliferation	GO:0008283	299	0.395
stem cell proliferation	GO:0072089	88	0.390
cardioblast cell fate specification	GO:0042685	9	0.379
embryonic organ development	GO:0048568	50	0.369
salivary gland development	GO:0007431	162	0.367
digestive tract development	GO:0048565	149	0.352
asymmetric cell division	GO:0008356	37	0.342
negative regulation of cell differentiation	GO:0045596	143	0.338
positive regulation of biosynthetic process	GO:0009891	316	0.322
actin filament bundle organization	GO:0061572	28	0.322
formation of organ boundary	GO:0010160	30	0.318
spermatid differentiation	GO:0048515	114	0.317
positive regulation of cell development	GO:0010720	61	0.315
positive regulation of gene expression	GO:0010628	290	0.306
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.305
kidney development	GO:0001822	3	0.296
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.296
regulation of cell development	GO:0060284	215	0.292
regulation of neurogenesis	GO:0050767	158	0.281
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.277
gastrulation	GO:0007369	70	0.276
positive regulation of rna biosynthetic process	GO:1902680	266	0.276
skin development	GO:0043588	65	0.276
respiratory system development	GO:0060541	213	0.274
negative regulation of neurogenesis	GO:0050768	53	0.273
photoreceptor cell differentiation	GO:0046530	170	0.271
germ cell migration	GO:0008354	43	0.270
death	GO:0016265	284	0.261
imaginal disc derived leg morphogenesis	GO:0007480	80	0.261
cardiac cell fate specification	GO:0060912	10	0.261
negative regulation of gene expression	GO:0010629	387	0.255
positive regulation of neuron differentiation	GO:0045666	26	0.253
negative regulation of response to stimulus	GO:0048585	258	0.243
central nervous system neuron differentiation	GO:0021953	8	0.242
cell migration	GO:0016477	238	0.241
localization of cell	GO:0051674	257	0.240
axon extension	GO:0048675	32	0.238
negative regulation of cell development	GO:0010721	62	0.236
negative regulation of signaling	GO:0023057	219	0.235
chaeta development	GO:0022416	97	0.234
regulation of eye photoreceptor cell development	GO:0042478	13	0.230
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.229
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.227
imaginal disc pattern formation	GO:0007447	91	0.224
regulation of neuron projection development	GO:0010975	69	0.222
neuroblast proliferation	GO:0007405	74	0.215
exocrine system development	GO:0035272	162	0.212
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.211
positive regulation of rna metabolic process	GO:0051254	271	0.202
germ line stem cell maintenance	GO:0030718	50	0.199
synapse organization	GO:0050808	196	0.195
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.190
spermatid development	GO:0007286	98	0.190
epidermal cell differentiation	GO:0009913	51	0.189
wing disc dorsal ventral pattern formation	GO:0048190	47	0.187
neuron fate commitment	GO:0048663	50	0.185
positive regulation of cellular biosynthetic process	GO:0031328	316	0.178
cell recognition	GO:0008037	102	0.177
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.175
sex differentiation	GO:0007548	81	0.170
tissue morphogenesis	GO:0048729	297	0.168
regulation of stem cell proliferation	GO:0072091	40	0.167
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.167
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.165
neuron projection extension	GO:1990138	32	0.165
gland morphogenesis	GO:0022612	145	0.165
biological adhesion	GO:0022610	138	0.164
positive regulation of response to stimulus	GO:0048584	323	0.160
olfactory behavior	GO:0042048	97	0.158
substrate dependent cell migration	GO:0006929	3	0.156
negative regulation of developmental process	GO:0051093	201	0.150
regulation of wnt signaling pathway	GO:0030111	68	0.150
apoptotic process	GO:0006915	159	0.150
extracellular matrix organization	GO:0030198	32	0.149
regulation of multicellular organismal development	GO:2000026	414	0.148
hair cell differentiation	GO:0035315	47	0.147
regulation of cell projection organization	GO:0031344	92	0.146
regulation of cell morphogenesis	GO:0022604	163	0.146
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.143
pericardium morphogenesis	GO:0003344	2	0.143
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.142
cardiac cell fate commitment	GO:0060911	17	0.137
neuron fate specification	GO:0048665	12	0.135
regulation of cellular component movement	GO:0051270	42	0.127
actin filament bundle assembly	GO:0051017	26	0.125
g protein coupled receptor signaling pathway	GO:0007186	136	0.124
positive regulation of cell migration	GO:0030335	2	0.122
male gamete generation	GO:0048232	201	0.121
eye antennal disc development	GO:0035214	60	0.120
positive regulation of programmed cell death	GO:0043068	62	0.115
regulation of neural precursor cell proliferation	GO:2000177	35	0.115
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.112
actin filament based process	GO:0030029	220	0.109
positive regulation of cell differentiation	GO:0045597	64	0.108
development of primary sexual characteristics	GO:0045137	50	0.108
malpighian tubule tip cell differentiation	GO:0061382	9	0.106
dendrite guidance	GO:0070983	21	0.106
salivary gland morphogenesis	GO:0007435	145	0.104
regulation of immune system process	GO:0002682	176	0.102
hindbrain development	GO:0030902	2	0.101
cell division	GO:0051301	248	0.101
developmental programmed cell death	GO:0010623	138	0.100
regulation of compound eye photoreceptor development	GO:0045314	12	0.100
segmentation	GO:0035282	207	0.099
organ formation	GO:0048645	39	0.094
cell fate specification	GO:0001708	71	0.093
response to nitrogen compound	GO:1901698	90	0.093
central nervous system development	GO:0007417	201	0.093
formation of anatomical boundary	GO:0048859	37	0.092
establishment of ommatidial planar polarity	GO:0042067	49	0.090
positive regulation of multicellular organismal process	GO:0051240	143	0.088
gland development	GO:0048732	191	0.086
ovarian follicle cell stalk formation	GO:0030713	17	0.084
regulation of molecular function	GO:0065009	217	0.083
actin filament organization	GO:0007015	126	0.083
positive regulation of molecular function	GO:0044093	136	0.083
gonad development	GO:0008406	50	0.082
ovarian follicle cell development	GO:0030707	248	0.082
establishment of planar polarity	GO:0001736	87	0.079
neuroblast development	GO:0014019	13	0.079
cardiovascular system development	GO:0072358	82	0.077
muscle cell differentiation	GO:0042692	103	0.076
renal filtration cell differentiation	GO:0061318	12	0.076
mushroom body development	GO:0016319	70	0.075
circulatory system development	GO:0072359	82	0.074
larval lymph gland hemopoiesis	GO:0035167	17	0.073
tube morphogenesis	GO:0035239	191	0.073
hemocyte differentiation	GO:0042386	38	0.073
embryonic hemopoiesis	GO:0035162	26	0.072
ras protein signal transduction	GO:0007265	88	0.071
epithelium migration	GO:0090132	148	0.071
translation	GO:0006412	69	0.071
glial cell proliferation	GO:0014009	13	0.067
photoreceptor cell fate commitment	GO:0046552	41	0.067
response to organic substance	GO:0010033	284	0.067
reproductive system development	GO:0061458	74	0.066
reproductive structure development	GO:0048608	74	0.065
negative regulation of epithelial cell migration	GO:0010633	1	0.064
regulation of mitotic cell cycle	GO:0007346	190	0.062
convergent extension	GO:0060026	2	0.062
negative regulation of nervous system development	GO:0051961	92	0.062
regulation of cell fate commitment	GO:0010453	29	0.060
eggshell chorion assembly	GO:0007306	66	0.060
spinal cord dorsal ventral patterning	GO:0021513	1	0.060
negative regulation of notch signaling pathway	GO:0045746	41	0.059
positive regulation of signaling	GO:0023056	243	0.059
synaptic target recognition	GO:0008039	45	0.059
cuticle pattern formation	GO:0035017	27	0.058
limb morphogenesis	GO:0035108	1	0.058
morphogenesis of a polarized epithelium	GO:0001738	93	0.057
gastrulation involving germ band extension	GO:0010004	36	0.057
erbb signaling pathway	GO:0038127	58	0.057
mesoderm development	GO:0007498	78	0.056
response to endogenous stimulus	GO:0009719	119	0.056
regulation of cell migration	GO:0030334	22	0.056
regulation of axon guidance	GO:1902667	10	0.056
stem cell division	GO:0017145	69	0.055
response to acid chemical	GO:0001101	25	0.055
regulation of cell fate specification	GO:0042659	27	0.055
regulation of cardioblast differentiation	GO:0051890	9	0.054
sensory organ precursor cell fate determination	GO:0016360	19	0.054
muscle tissue morphogenesis	GO:0060415	2	0.053
asymmetric stem cell division	GO:0098722	49	0.052
muscle organ morphogenesis	GO:0048644	7	0.052
camera type eye development	GO:0043010	4	0.051
wing disc pattern formation	GO:0035222	66	0.051
regulation of cytoskeleton organization	GO:0051493	89	0.051
regulation of synapse assembly	GO:0051963	94	0.050
histolysis	GO:0007559	102	0.049
spermatogenesis	GO:0007283	200	0.049
epithelial cell migration open tracheal system	GO:0007427	32	0.048
post embryonic hemopoiesis	GO:0035166	17	0.047
gliogenesis	GO:0042063	80	0.047
morphogenesis of an epithelium	GO:0002009	276	0.047
cell maturation	GO:0048469	144	0.046
negative regulation of cell proliferation	GO:0008285	69	0.046
r3 r4 cell fate commitment	GO:0007464	10	0.045
regulation of phosphorylation	GO:0042325	147	0.045
positive regulation of cell motility	GO:2000147	3	0.045
imaginal disc derived wing hair organization	GO:0035317	45	0.045
segment polarity determination	GO:0007367	25	0.044
imaginal disc derived wing vein specification	GO:0007474	48	0.044
regulation of protein metabolic process	GO:0051246	256	0.044
positive regulation of wnt signaling pathway	GO:0030177	25	0.043
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.043
organonitrogen compound metabolic process	GO:1901564	318	0.043
axon midline choice point recognition	GO:0016199	26	0.042
cardiocyte differentiation	GO:0035051	29	0.042
embryonic hindgut morphogenesis	GO:0048619	48	0.042
retina development in camera type eye	GO:0060041	4	0.042
embryo development ending in birth or egg hatching	GO:0009792	152	0.042
regulation of axonogenesis	GO:0050770	32	0.041
r8 cell differentiation	GO:0045465	13	0.041
r8 cell fate commitment	GO:0007460	6	0.041
negative regulation of smoothened signaling pathway	GO:0045879	16	0.041
male sex differentiation	GO:0046661	25	0.041
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO:1902254	1	0.040
muscle cell development	GO:0055001	50	0.040
neurological system process	GO:0050877	358	0.040
endocytosis	GO:0006897	310	0.039
connective tissue development	GO:0061448	3	0.038
neuron migration	GO:0001764	5	0.038
single organism behavior	GO:0044708	391	0.038
malpighian tubule development	GO:0072002	64	0.037
neuroepithelial cell differentiation	GO:0060563	6	0.037
compound eye retinal cell programmed cell death	GO:0046667	23	0.037
axon choice point recognition	GO:0016198	26	0.036
cell adhesion	GO:0007155	136	0.036
apoptotic process involved in morphogenesis	GO:0060561	3	0.036
regulation of epithelial cell differentiation	GO:0030856	4	0.036
ameboidal type cell migration	GO:0001667	151	0.036
peptidyl serine phosphorylation	GO:0018105	7	0.036
negative regulation of cell communication	GO:0010648	223	0.035
muscle structure development	GO:0061061	224	0.035
humoral immune response	GO:0006959	117	0.035
establishment or maintenance of cell polarity	GO:0007163	167	0.035
positive regulation of notch signaling pathway	GO:0045747	34	0.034
dorsal appendage formation	GO:0046843	47	0.034
cell growth	GO:0016049	108	0.034
renal tubule development	GO:0061326	64	0.033
vesicle mediated transport	GO:0016192	381	0.032
positive regulation of catalytic activity	GO:0043085	118	0.032
anatomical structure homeostasis	GO:0060249	97	0.032
regulation of cellular component size	GO:0032535	98	0.032
leg disc development	GO:0035218	92	0.031
regulation of epithelial cell migration	GO:0010632	12	0.030
eye photoreceptor cell development	GO:0042462	81	0.030
actin cytoskeleton organization	GO:0030036	206	0.030
cell fate commitment involved in pattern specification	GO:0060581	31	0.030
cell migration involved in gastrulation	GO:0042074	9	0.029
epithelial tube morphogenesis	GO:0060562	88	0.029
cellular catabolic process	GO:0044248	372	0.029
glial cell differentiation	GO:0010001	35	0.028
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.028
embryonic heart tube development	GO:0035050	22	0.028
blastoderm segmentation	GO:0007350	159	0.028
negative regulation of cell death	GO:0060548	81	0.028
limb development	GO:0060173	1	0.027
formation of primary germ layer	GO:0001704	24	0.027
developmental cell growth	GO:0048588	52	0.027
immune response	GO:0006955	246	0.027
regulation of cellular protein metabolic process	GO:0032268	243	0.027
cardioblast differentiation	GO:0010002	20	0.027
epithelial cell proliferation involved in renal tubule morphogenesis	GO:2001013	11	0.027
response to oxygen containing compound	GO:1901700	200	0.026
cellular amide metabolic process	GO:0043603	80	0.026
axon extension involved in axon guidance	GO:0048846	10	0.026
striated muscle cell differentiation	GO:0051146	90	0.026
rho protein signal transduction	GO:0007266	14	0.026
periodic partitioning	GO:0007365	29	0.026
anterior posterior pattern specification	GO:0009952	136	0.025
apoptotic process involved in development	GO:1902742	20	0.025
tissue death	GO:0016271	102	0.025
digestive system development	GO:0055123	149	0.025
developmental growth involved in morphogenesis	GO:0060560	65	0.025
establishment or maintenance of polarity of larval imaginal disc epithelium	GO:0016336	3	0.025
striated muscle tissue development	GO:0014706	27	0.024
chorion containing eggshell formation	GO:0007304	105	0.024
neuron maturation	GO:0042551	31	0.024
sensory perception of smell	GO:0007608	80	0.023
chromatin organization	GO:0006325	207	0.023
regulation of ras protein signal transduction	GO:0046578	93	0.022
specification of organ identity	GO:0010092	3	0.022
positive regulation of developmental process	GO:0051094	143	0.022
r3 r4 cell differentiation	GO:0048056	12	0.022
second mitotic wave involved in compound eye morphogenesis	GO:0016330	7	0.022
chromosome organization	GO:0051276	360	0.022
nephron epithelium development	GO:0072009	3	0.022
mesenchymal cell differentiation	GO:0048762	1	0.022
neuromuscular process	GO:0050905	21	0.021
regulation of neuroblast proliferation	GO:1902692	34	0.021
positive regulation of protein import into nucleus translocation	GO:0033160	2	0.021
negative regulation of neuron differentiation	GO:0045665	16	0.021
salivary gland cell autophagic cell death	GO:0035071	83	0.021
regulation of organelle organization	GO:0033043	196	0.021
catabolic process	GO:0009056	409	0.020
regulation of phosphatase activity	GO:0010921	3	0.020
positive regulation of hydrolase activity	GO:0051345	78	0.020
regulation of cellular catabolic process	GO:0031329	157	0.020
muscle cell fate specification	GO:0042694	7	0.020
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	26	0.020
programmed cell death	GO:0012501	257	0.020
multicellular organismal homeostasis	GO:0048871	41	0.019
response to organonitrogen compound	GO:0010243	75	0.019
photoreceptor cell development	GO:0042461	96	0.019
gastrulation with mouth forming first	GO:0001703	36	0.019
eggshell formation	GO:0030703	105	0.019
response to other organism	GO:0051707	293	0.019
peptidyl serine modification	GO:0018209	7	0.019
positive regulation of cellular protein metabolic process	GO:0032270	118	0.019
regulation of protein modification process	GO:0031399	112	0.018
female germ line stem cell asymmetric division	GO:0048132	14	0.018
regulation of cell proliferation	GO:0042127	163	0.018
cardiac muscle tissue development	GO:0048738	9	0.018
regulation of cell motility	GO:2000145	23	0.018
positive regulation of cellular component biogenesis	GO:0044089	80	0.018
positive regulation of transcription from rna polymerase i promoter	GO:0045943	3	0.018
regulation of organ growth	GO:0046620	42	0.017
pericardium development	GO:0060039	2	0.017
cellular response to oxygen containing compound	GO:1901701	79	0.017
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.017
long term memory	GO:0007616	62	0.017
camera type eye morphogenesis	GO:0048593	2	0.017
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.017
genitalia development	GO:0048806	26	0.017
glycosyl compound metabolic process	GO:1901657	127	0.017
nephron development	GO:0072006	3	0.017
compartment pattern specification	GO:0007386	5	0.016
juvenile hormone mediated signaling pathway	GO:0035626	3	0.016
cell death	GO:0008219	279	0.016
immune system development	GO:0002520	57	0.016
positive regulation of cell death	GO:0010942	69	0.016
negative regulation of cell cycle	GO:0045786	116	0.016
roundabout signaling pathway	GO:0035385	4	0.016
leg disc morphogenesis	GO:0007478	80	0.016
regulation of anatomical structure size	GO:0090066	163	0.016
autophagy	GO:0006914	108	0.016
positive regulation of protein phosphorylation	GO:0001934	34	0.016
regulation of translation	GO:0006417	56	0.016
regulation of hematopoietic progenitor cell differentiation	GO:1901532	1	0.016
single organismal cell cell adhesion	GO:0016337	45	0.016
organelle inheritance	GO:0048308	2	0.016
negative regulation of multicellular organismal process	GO:0051241	142	0.015
cell cell adhesion	GO:0098609	26	0.015
lymph gland development	GO:0048542	28	0.015
cellular protein modification process	GO:0006464	438	0.015
regulation of synaptic transmission	GO:0050804	69	0.015
developmental induction	GO:0031128	3	0.015
negative regulation of mitotic anaphase promoting complex activity	GO:0060564	2	0.015
cell fate commitment involved in formation of primary germ layer	GO:0060795	10	0.015
cuticle development	GO:0042335	86	0.015
asymmetric neuroblast division	GO:0055059	33	0.015
small gtpase mediated signal transduction	GO:0007264	88	0.015
regulation of phospholipase activity	GO:0010517	2	0.015
epithelial cell type specification open tracheal system	GO:0035153	11	0.014
regulation of viral genome replication	GO:0045069	4	0.014
canonical wnt signaling pathway involved in heart development	GO:0061316	3	0.014
response to biotic stimulus	GO:0009607	294	0.014
smoothened signaling pathway	GO:0007224	49	0.014
developmental growth	GO:0048589	280	0.014
response to temperature stimulus	GO:0009266	106	0.014
heart morphogenesis	GO:0003007	32	0.014
cellular response to fibroblast growth factor stimulus	GO:0044344	10	0.014
cardioblast cell fate commitment	GO:0042684	14	0.014
torso signaling pathway	GO:0008293	21	0.014
regulation of cytoplasmic transport	GO:1903649	47	0.014
signal transduction in response to dna damage	GO:0042770	3	0.013
cellular response to organic substance	GO:0071310	132	0.013
regulation of tube architecture open tracheal system	GO:0035152	68	0.013
regulation of localization	GO:0032879	275	0.013
semaphorin plexin signaling pathway	GO:0071526	4	0.013
defense response to other organism	GO:0098542	225	0.013
glial cell fate commitment	GO:0021781	3	0.013
neural retina development	GO:0003407	4	0.013
glial cell fate determination	GO:0007403	3	0.013
histone h3 s10 phosphorylation	GO:0043987	2	0.013
regulation of bmp signaling pathway	GO:0030510	23	0.013
cellular response to chemical stimulus	GO:0070887	199	0.012
regulation of locomotion	GO:0040012	42	0.012
nucleotide catabolic process	GO:0009166	109	0.012
wnt signaling pathway	GO:0016055	98	0.012
regulation of embryonic cell shape	GO:0016476	30	0.012
carbohydrate derivative metabolic process	GO:1901135	217	0.012
brain morphogenesis	GO:0048854	16	0.012
negative regulation of cellular component organization	GO:0051129	108	0.012
regulation of gtpase activity	GO:0043087	44	0.012
response to extracellular stimulus	GO:0009991	116	0.012
male gonad development	GO:0008584	9	0.012
icosanoid biosynthetic process	GO:0046456	1	0.012
digestive tract morphogenesis	GO:0048546	127	0.012
nephrocyte differentiation	GO:0061319	12	0.012
chemosensory behavior	GO:0007635	106	0.011
oocyte development	GO:0048599	124	0.011
positive regulation of cellular catabolic process	GO:0031331	95	0.011
immune effector process	GO:0002252	98	0.011
protein modification by small protein conjugation	GO:0032446	79	0.011
body morphogenesis	GO:0010171	2	0.011
positive regulation of phosphorus metabolic process	GO:0010562	139	0.011
determination of bilateral symmetry	GO:0009855	13	0.011
positive regulation of cell communication	GO:0010647	250	0.011
positive regulation of protein metabolic process	GO:0051247	128	0.011
regulation of intracellular protein transport	GO:0033157	46	0.011
regulation of actin filament based process	GO:0032970	42	0.011
glial cell migration	GO:0008347	31	0.010
regulation of phosphoprotein phosphatase activity	GO:0043666	3	0.010
positive regulation of epithelial cell differentiation	GO:0030858	1	0.010
mesenchymal cell development	GO:0014031	1	0.010
meiotic cell cycle	GO:0051321	171	0.010
regulation of organ morphogenesis	GO:2000027	78	0.010
antimicrobial humoral response	GO:0019730	99	0.010
axonal fasciculation	GO:0007413	12	0.010
regulation of circadian rhythm	GO:0042752	49	0.010
regulation of catalytic activity	GO:0050790	185	0.010
negative regulation of mitotic cell cycle	GO:0045930	109	0.010

mam disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.044
organ system cancer	DOID:0050686	0.044
disease of cellular proliferation	DOID:14566	0.044
nervous system disease	DOID:863	0.018
disease of anatomical entity	DOID:7	0.018
spondylocostal dysostosis	DOID:0050568	0.012
bone development disease	DOID:0080006	0.012
bone disease	DOID:0080001	0.012
dysostosis	DOID:1934	0.012
musculoskeletal system disease	DOID:17	0.012
connective tissue disease	DOID:65	0.012

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