IMP: Integrative Multi-species Prediction

Drosophila melanogaster

75 known processes

Vps16A (Dmel_CG8454)

Vacuolar protein sorting 16A

(Aliases: DmVps16,Dmel\CG8454,CG8454,dVps16A,Vps16)

FLYBASE: FBgn0261241
Entrez: 41107
UniProtKB: Q9VHG1

Process Predictions
Disease Predictions

Vps16A biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
macroautophagy	GO:0016236	42	0.924
organelle membrane fusion	GO:0090174	16	0.800
cellular response to extracellular stimulus	GO:0031668	64	0.782
autophagic vacuole fusion	GO:0000046	15	0.755
cellular response to starvation	GO:0009267	61	0.750
single organism membrane fusion	GO:0044801	42	0.725
cellular response to external stimulus	GO:0071496	66	0.659
cellular response to nutrient levels	GO:0031669	62	0.654
response to starvation	GO:0042594	97	0.630
cellular catabolic process	GO:0044248	372	0.623
single organism catabolic process	GO:0044712	228	0.622
vesicle organization	GO:0016050	44	0.595
autophagy	GO:0006914	108	0.576
endosomal transport	GO:0016197	44	0.574
cell proliferation	GO:0008283	299	0.554
membrane organization	GO:0061024	112	0.528
organelle fusion	GO:0048284	46	0.524
catabolic process	GO:0009056	409	0.513
gene silencing by mirna	GO:0035195	22	0.492
endocytosis	GO:0006897	310	0.477
response to extracellular stimulus	GO:0009991	116	0.393
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.381
organic cyclic compound catabolic process	GO:1901361	168	0.360
nucleoside metabolic process	GO:0009116	127	0.359
negative regulation of developmental process	GO:0051093	201	0.358
guanosine containing compound metabolic process	GO:1901068	74	0.347
lysosomal transport	GO:0007041	13	0.338
vesicle mediated transport	GO:0016192	381	0.330
defense response to bacterium	GO:0042742	178	0.326
intracellular transport	GO:0046907	228	0.321
glycosyl compound catabolic process	GO:1901658	112	0.319
membrane fusion	GO:0061025	42	0.316
immune system process	GO:0002376	347	0.300
organelle assembly	GO:0070925	198	0.261
response to nutrient levels	GO:0031667	114	0.232
regulation of catabolic process	GO:0009894	170	0.227
neuron remodeling	GO:0016322	29	0.227
purine nucleoside metabolic process	GO:0042278	127	0.223
defense response to other organism	GO:0098542	225	0.201
vacuolar transport	GO:0007034	13	0.196
developmental pigmentation	GO:0048066	68	0.195
regulation of vesicle mediated transport	GO:0060627	59	0.193
carbohydrate derivative catabolic process	GO:1901136	118	0.191
neural precursor cell proliferation	GO:0061351	75	0.187
negative regulation of cellular metabolic process	GO:0031324	382	0.186
purine containing compound metabolic process	GO:0072521	155	0.181
endosome to lysosome transport	GO:0008333	7	0.179
ribonucleoside catabolic process	GO:0042454	112	0.178
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.171
gtp metabolic process	GO:0046039	72	0.160
regulation of defense response to virus by host	GO:0050691	10	0.158
nucleoside triphosphate catabolic process	GO:0009143	108	0.155
nucleoside catabolic process	GO:0009164	112	0.155
guanosine containing compound catabolic process	GO:1901069	74	0.154
cellular pigmentation	GO:0033059	12	0.148
nucleobase containing compound catabolic process	GO:0034655	165	0.145
glycosyl compound metabolic process	GO:1901657	127	0.142
heterocycle catabolic process	GO:0046700	166	0.140
regulation of cellular component size	GO:0032535	98	0.138
immune effector process	GO:0002252	98	0.137
purine nucleotide catabolic process	GO:0006195	109	0.137
small molecule metabolic process	GO:0044281	305	0.135
negative regulation of neuroblast proliferation	GO:0007406	27	0.131
stem cell proliferation	GO:0072089	88	0.127
carbohydrate derivative metabolic process	GO:1901135	217	0.124
defense response	GO:0006952	300	0.123
ribonucleotide catabolic process	GO:0009261	109	0.123
purine ribonucleoside metabolic process	GO:0046128	127	0.122
neuron maturation	GO:0042551	31	0.119
response to other organism	GO:0051707	293	0.119
aromatic compound catabolic process	GO:0019439	166	0.118
cellular nitrogen compound catabolic process	GO:0044270	165	0.116
posttranscriptional gene silencing by rna	GO:0035194	45	0.115
ribose phosphate metabolic process	GO:0019693	145	0.114
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.111
ribonucleoside metabolic process	GO:0009119	127	0.111
histolysis	GO:0007559	102	0.107
homeostatic process	GO:0042592	199	0.107
regulation of cell size	GO:0008361	63	0.106
negative regulation of cell differentiation	GO:0045596	143	0.104
purine ribonucleoside catabolic process	GO:0046130	112	0.103
response to external biotic stimulus	GO:0043207	293	0.103
spermatid development	GO:0007286	98	0.101
phagocytosis	GO:0006909	215	0.101
nucleotide catabolic process	GO:0009166	109	0.101
purine nucleoside catabolic process	GO:0006152	112	0.100
male gamete generation	GO:0048232	201	0.098
organic substance catabolic process	GO:1901575	308	0.096
anatomical structure homeostasis	GO:0060249	97	0.094
nucleoside triphosphate metabolic process	GO:0009141	120	0.093
protein localization	GO:0008104	284	0.092
purine containing compound catabolic process	GO:0072523	112	0.090
purine ribonucleotide catabolic process	GO:0009154	109	0.090
single organism intracellular transport	GO:1902582	207	0.089
regulation of autophagy	GO:0010506	62	0.088
organophosphate metabolic process	GO:0019637	195	0.088
posttranscriptional regulation of gene expression	GO:0010608	145	0.086
negative regulation of stem cell proliferation	GO:2000647	30	0.086
nucleoside phosphate metabolic process	GO:0006753	162	0.085
ribonucleotide metabolic process	GO:0009259	145	0.085
regulation of defense response	GO:0031347	102	0.083
regulation of anatomical structure size	GO:0090066	163	0.082
rho protein signal transduction	GO:0007266	14	0.081
pigment metabolic process	GO:0042440	84	0.079
nucleobase containing small molecule metabolic process	GO:0055086	174	0.077
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.076
neuroblast proliferation	GO:0007405	74	0.076
establishment of localization in cell	GO:0051649	402	0.074
organonitrogen compound catabolic process	GO:1901565	128	0.073
organonitrogen compound metabolic process	GO:1901564	318	0.073
gtp catabolic process	GO:0006184	72	0.072
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.071
nucleotide metabolic process	GO:0009117	161	0.070
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.070
cell maturation	GO:0048469	144	0.068
gene silencing	GO:0016458	138	0.066
purine ribonucleotide metabolic process	GO:0009150	145	0.064
regulation of multi organism process	GO:0043900	131	0.064
regulation of antibacterial peptide production	GO:0002786	22	0.064
endomembrane system organization	GO:0010256	119	0.063
apoptotic cell clearance	GO:0043277	14	0.062
organophosphate catabolic process	GO:0046434	112	0.062
single organism membrane organization	GO:0044802	93	0.061
stem cell differentiation	GO:0048863	117	0.061
positive regulation of hydrolase activity	GO:0051345	78	0.060
lateral inhibition	GO:0046331	206	0.060
response to biotic stimulus	GO:0009607	294	0.060
regulation of defense response to virus	GO:0050688	14	0.059
developmental maturation	GO:0021700	172	0.058
response to bacterium	GO:0009617	198	0.058
regulation of innate immune response	GO:0045088	71	0.058
cell division	GO:0051301	248	0.057
regulation of response to stress	GO:0080134	200	0.056
melanization defense response	GO:0035006	45	0.056
regulation of translation	GO:0006417	56	0.055
axonogenesis	GO:0007409	290	0.055
regulation of growth	GO:0040008	233	0.055
negative regulation of signaling	GO:0023057	219	0.053
spermatogenesis	GO:0007283	200	0.053
regulation of wnt signaling pathway	GO:0030111	68	0.053
regulation of cellular catabolic process	GO:0031329	157	0.053
gene silencing by rna	GO:0031047	57	0.052
regulation of multicellular organismal development	GO:2000026	414	0.052
wing disc morphogenesis	GO:0007472	344	0.051
regulation of cell proliferation	GO:0042127	163	0.050
antimicrobial peptide production	GO:0002775	46	0.049
regulation of ras gtpase activity	GO:0032318	38	0.047
innate immune response	GO:0045087	144	0.047
purine nucleotide metabolic process	GO:0006163	146	0.047
cytokinesis	GO:0000910	90	0.046
regulation of programmed cell death	GO:0043067	152	0.045
positive regulation of catabolic process	GO:0009896	105	0.045
dna metabolic process	GO:0006259	227	0.045
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.045
negative regulation of multicellular organismal process	GO:0051241	142	0.045
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.044
regulation of hydrolase activity	GO:0051336	97	0.043
regulation of cell differentiation	GO:0045595	302	0.043
regulation of transport	GO:0051049	181	0.042
cytoplasmic transport	GO:0016482	130	0.042
posttranscriptional gene silencing	GO:0016441	46	0.042
regulation of gtpase activity	GO:0043087	44	0.041
regulation of macroautophagy	GO:0016241	15	0.040
chaeta morphogenesis	GO:0008407	42	0.040
regulation of cell development	GO:0060284	215	0.040
developmental growth	GO:0048589	280	0.040
programmed cell death	GO:0012501	257	0.040
exocrine system development	GO:0035272	162	0.039
developmental programmed cell death	GO:0010623	138	0.038
positive regulation of endopeptidase activity	GO:0010950	26	0.037
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.037
regulation of apoptotic process	GO:0042981	130	0.036
regulation of peptidase activity	GO:0052547	39	0.036
nucleoside phosphate catabolic process	GO:1901292	110	0.036
eye photoreceptor cell development	GO:0042462	81	0.036
compound eye development	GO:0048749	307	0.036
regulation of developmental growth	GO:0048638	174	0.036
lipid localization	GO:0010876	54	0.036
positive regulation of gtpase activity	GO:0043547	43	0.036
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.035
centrosome cycle	GO:0007098	137	0.035
ommochrome biosynthetic process	GO:0006727	19	0.034
positive regulation of ras gtpase activity	GO:0032320	36	0.034
phagocytosis engulfment	GO:0006911	11	0.034
cell fate determination	GO:0001709	91	0.034
rna processing	GO:0006396	147	0.033
regulation of endopeptidase activity	GO:0052548	36	0.033
spermatid differentiation	GO:0048515	114	0.033
pigmentation	GO:0043473	75	0.033
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.033
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.033
appendage development	GO:0048736	401	0.033
regulation of protein metabolic process	GO:0051246	256	0.033
negative regulation of biosynthetic process	GO:0009890	277	0.032
establishment of protein localization	GO:0045184	163	0.031
protein transport	GO:0015031	155	0.031
negative regulation of gene expression	GO:0010629	387	0.031
regulation of cellular component biogenesis	GO:0044087	201	0.031
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.031
wnt signaling pathway	GO:0016055	98	0.030
axon development	GO:0061564	297	0.030
positive regulation of defense response	GO:0031349	59	0.030
hematopoietic or lymphoid organ development	GO:0048534	57	0.030
positive regulation of antibacterial peptide production	GO:0002803	20	0.030
macromolecule catabolic process	GO:0009057	161	0.030
cellular response to heat	GO:0034605	24	0.029
salivary gland histolysis	GO:0035070	88	0.029
negative regulation of cell cycle process	GO:0010948	109	0.029
defense response to gram negative bacterium	GO:0050829	94	0.029
plasma membrane organization	GO:0007009	26	0.029
regulation of purine nucleotide catabolic process	GO:0033121	48	0.028
establishment of rna localization	GO:0051236	47	0.028
negative regulation of neurogenesis	GO:0050768	53	0.028
regulation of immune response	GO:0050776	118	0.028
compound eye photoreceptor development	GO:0042051	78	0.027
cell motility	GO:0048870	251	0.027
antibacterial humoral response	GO:0019731	44	0.027
protein localization to plasma membrane	GO:0072659	13	0.027
appendage morphogenesis	GO:0035107	397	0.027
regulation of catalytic activity	GO:0050790	185	0.027
endocytic recycling	GO:0032456	13	0.027
nucleobase containing compound transport	GO:0015931	56	0.026
regulation of cellular protein metabolic process	GO:0032268	243	0.026
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.026
response to organic substance	GO:0010033	284	0.026
positive regulation of signal transduction	GO:0009967	223	0.026
mrna processing	GO:0006397	104	0.026
regulation of localization	GO:0032879	275	0.025
positive regulation of nucleotide catabolic process	GO:0030813	46	0.025
oxidation reduction process	GO:0055114	123	0.025
salivary gland cell autophagic cell death	GO:0035071	83	0.025
secondary metabolic process	GO:0019748	75	0.025
regulation of stem cell proliferation	GO:0072091	40	0.025
positive regulation of gene expression	GO:0010628	290	0.025
cellular response to organic substance	GO:0071310	132	0.025
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.025
defense response to virus	GO:0051607	23	0.024
protein modification process	GO:0036211	438	0.024
localization of cell	GO:0051674	257	0.024
response to organophosphorus	GO:0046683	2	0.024
regulation of cell death	GO:0010941	173	0.023
positive regulation of peptidase activity	GO:0010952	29	0.023
meiotic nuclear division	GO:0007126	151	0.023
positive regulation of defense response to virus by host	GO:0002230	10	0.023
organic substance transport	GO:0071702	257	0.023
eye antennal disc development	GO:0035214	60	0.023
single organism biosynthetic process	GO:0044711	206	0.023
positive regulation of response to stimulus	GO:0048584	323	0.022
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.022
apoptotic process	GO:0006915	159	0.022
lipid metabolic process	GO:0006629	121	0.021
regulation of gene silencing	GO:0060968	63	0.021
rna 3 end processing	GO:0031123	45	0.021
regulation of mitotic cell cycle	GO:0007346	190	0.021
myoblast fusion	GO:0007520	43	0.020
eggshell formation	GO:0030703	105	0.020
positive regulation of immune response	GO:0050778	63	0.020
immune system development	GO:0002520	57	0.020
membrane invagination	GO:0010324	11	0.020
regulation of response to external stimulus	GO:0032101	115	0.020
regulation of stress activated mapk cascade	GO:0032872	41	0.020
epidermis development	GO:0008544	65	0.020
positive regulation of gtp catabolic process	GO:0033126	43	0.020
protein heterooligomerization	GO:0051291	4	0.020
production of sirna involved in rna interference	GO:0030422	11	0.019
positive regulation of catalytic activity	GO:0043085	118	0.019
pole cell formation	GO:0007279	19	0.019
negative regulation of cellular protein metabolic process	GO:0032269	85	0.019
compound eye pigmentation	GO:0048072	17	0.019
dna endoreduplication	GO:0042023	22	0.019
response to lipopolysaccharide	GO:0032496	4	0.019
negative regulation of cellular biosynthetic process	GO:0031327	277	0.019
regulation of antibacterial peptide biosynthetic process	GO:0002808	22	0.018
rna transport	GO:0050658	46	0.018
retina development in camera type eye	GO:0060041	4	0.018
response to organic cyclic compound	GO:0014070	89	0.018
ameboidal type cell migration	GO:0001667	151	0.018
protein acylation	GO:0043543	42	0.018
post embryonic appendage morphogenesis	GO:0035120	385	0.018
eye pigment biosynthetic process	GO:0006726	32	0.018
cellular response to chemical stimulus	GO:0070887	199	0.018
rna interference	GO:0016246	27	0.018
production of small rna involved in gene silencing by rna	GO:0070918	15	0.018
molting cycle	GO:0042303	56	0.018
negative regulation of translation	GO:0017148	28	0.018
peripheral nervous system development	GO:0007422	52	0.018
regulation of humoral immune response	GO:0002920	51	0.017
regulation of intracellular protein transport	GO:0033157	46	0.017
tube morphogenesis	GO:0035239	191	0.017
protein modification by small protein conjugation or removal	GO:0070647	106	0.017
regulation of synapse organization	GO:0050807	110	0.017
positive regulation of cellular catabolic process	GO:0031331	95	0.017
regulation of mrna metabolic process	GO:1903311	72	0.017
salivary gland development	GO:0007431	162	0.017
heterochromatin organization	GO:0070828	25	0.017
regulation of phosphatase activity	GO:0010921	3	0.017
rrna processing	GO:0006364	3	0.016
taxis	GO:0042330	304	0.016
positive regulation of innate immune response	GO:0045089	38	0.016
small rna loading onto risc	GO:0070922	6	0.016
intracellular signal transduction	GO:0035556	300	0.016
negative regulation of transcription dna templated	GO:0045892	237	0.016
cellular macromolecule localization	GO:0070727	220	0.016
proteolysis	GO:0006508	192	0.016
dendrite morphogenesis	GO:0048813	199	0.016
imaginal disc fusion	GO:0046528	19	0.016
regulation of gtp catabolic process	GO:0033124	44	0.016
regulation of molecular function	GO:0065009	217	0.016
death	GO:0016265	284	0.016
negative regulation of nervous system development	GO:0051961	92	0.016
protein localization to nucleus	GO:0034504	55	0.016
regulation of proteolysis	GO:0030162	87	0.016
neuron projection guidance	GO:0097485	241	0.016
synaptic transmission	GO:0007268	288	0.016
positive regulation of transport	GO:0051050	92	0.016
regulation of cytoplasmic transport	GO:1903649	47	0.015
epithelial cell differentiation	GO:0030855	322	0.015
protein targeting to nucleus	GO:0044744	51	0.015
positive regulation of molecular function	GO:0044093	136	0.015
mitotic dna integrity checkpoint	GO:0044774	75	0.015
tissue death	GO:0016271	102	0.014
regulation of production of molecular mediator of immune response	GO:0002700	44	0.014
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.014
cellular macromolecular complex assembly	GO:0034622	153	0.014
eye morphogenesis	GO:0048592	260	0.014
positive regulation of programmed cell death	GO:0043068	62	0.014
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.014
cellular response to lipopolysaccharide	GO:0071222	3	0.013
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.013
cellular homeostasis	GO:0019725	80	0.013
regulation of antimicrobial humoral response	GO:0002759	50	0.013
chemotaxis	GO:0006935	249	0.013
chromosome organization	GO:0051276	360	0.013
phagolysosome assembly	GO:0001845	2	0.013
translation	GO:0006412	69	0.013
aging	GO:0007568	143	0.013
cellular protein localization	GO:0034613	160	0.013
isoprenoid transport	GO:0046864	2	0.013
reactive oxygen species metabolic process	GO:0072593	22	0.013
regulation of response to extracellular stimulus	GO:0032104	18	0.013
multi multicellular organism process	GO:0044706	123	0.013
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.013
response to abiotic stimulus	GO:0009628	341	0.013
single organism cellular localization	GO:1902580	180	0.013
receptor mediated endocytosis	GO:0006898	21	0.013
regulation of protein localization	GO:0032880	76	0.013
germ line stem cell maintenance	GO:0030718	50	0.013
cellular response to dsrna	GO:0071359	15	0.013
endosome organization	GO:0007032	9	0.013
positive regulation of nucleotide metabolic process	GO:0045981	55	0.012
protein phosphorylation	GO:0006468	169	0.012
early endosome to late endosome transport	GO:0045022	3	0.012
epithelium migration	GO:0090132	148	0.012
regulation of rho protein signal transduction	GO:0035023	20	0.012
negative regulation of response to stimulus	GO:0048585	258	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.012
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.012
oocyte development	GO:0048599	124	0.012
regulation of response to biotic stimulus	GO:0002831	63	0.012
regulation of nucleotide catabolic process	GO:0030811	48	0.012
vesicle fusion	GO:0006906	19	0.012
stress activated mapk cascade	GO:0051403	52	0.012
photoreceptor cell development	GO:0042461	96	0.012
negative regulation of cell cycle phase transition	GO:1901988	103	0.012
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.012
cellular protein modification process	GO:0006464	438	0.011
positive regulation of cellular biosynthetic process	GO:0031328	316	0.011
determination of adult lifespan	GO:0008340	137	0.011
engulfment of apoptotic cell	GO:0043652	6	0.011
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria	GO:0002816	3	0.011
autophagic vacuole assembly	GO:0000045	2	0.011
morphogenesis of a branching epithelium	GO:0061138	45	0.011
single organism nuclear import	GO:1902593	51	0.011
compound eye morphogenesis	GO:0001745	249	0.011
golgi organization	GO:0007030	66	0.011
imaginal disc derived appendage development	GO:0048737	399	0.011
organic hydroxy compound metabolic process	GO:1901615	83	0.011
nuclear import	GO:0051170	51	0.011
regulation of protein import into nucleus	GO:0042306	28	0.011
positive regulation of rna metabolic process	GO:0051254	271	0.011
chaeta development	GO:0022416	97	0.010
negative regulation of apoptotic process	GO:0043066	63	0.010
notch signaling pathway	GO:0007219	120	0.010
imaginal disc derived wing morphogenesis	GO:0007476	337	0.010
positive regulation of protein metabolic process	GO:0051247	128	0.010
cell cycle checkpoint	GO:0000075	95	0.010
mrna 3 end processing	GO:0031124	28	0.010
regulation of cellular localization	GO:0060341	136	0.010
positive regulation of wnt signaling pathway	GO:0030177	25	0.010
response to radiation	GO:0009314	155	0.010
cellular response to dna damage stimulus	GO:0006974	223	0.010
regulation of nucleotide metabolic process	GO:0006140	62	0.010
collateral sprouting	GO:0048668	3	0.010
cellular response to cadmium ion	GO:0071276	6	0.010

Vps16A disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.032
	nervous system disease	DOID:863	0	0.014

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