IMP: Integrative Multi-species Prediction

Drosophila melanogaster

80 known processes

Klp3A (Dmel_CG8590)

Kinesin-like protein at 3A

(Aliases: fs(1)M4,DmKLP3A,KLP-3A,CG8590,BcDNA:LD21815,3A7Kin,KIF4,Dmel\CG8590,KIF4A,mei-352,Klp3a,DmKlp3A,KLP3A,EG:BACR25B3.9,klp3A)

Entrez: 31240
FLYBASE: FBgn0011606
UniProtKB: Q9XZ29

Process Predictions
Disease Predictions

Klp3A biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
meiotic cell cycle process	GO:1903046	132	1.000
organelle fission	GO:0048285	340	0.998
meiosis i	GO:0007127	59	0.997
nuclear division	GO:0000280	332	0.994
spindle organization	GO:0007051	253	0.980
cell division	GO:0051301	248	0.978
meiotic cell cycle	GO:0051321	171	0.975
mitotic spindle organization	GO:0007052	220	0.960
meiotic nuclear division	GO:0007126	151	0.912
male meiosis	GO:0007140	52	0.882
double strand break repair via nonhomologous end joining	GO:0006303	5	0.879
male meiosis cytokinesis	GO:0007112	26	0.866
spindle assembly involved in female meiosis	GO:0007056	14	0.844
chromosome segregation	GO:0007059	157	0.810
cytokinesis	GO:0000910	90	0.778
spindle assembly involved in female meiosis i	GO:0007057	5	0.770
meiotic spindle organization	GO:0000212	36	0.767
spindle assembly	GO:0051225	80	0.719
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.693
reciprocal dna recombination	GO:0035825	19	0.671
spindle assembly involved in meiosis	GO:0090306	20	0.659
organelle assembly	GO:0070925	198	0.642
negative regulation of cellular metabolic process	GO:0031324	382	0.612
meiosis ii	GO:0007135	23	0.592
chromosome organization	GO:0051276	360	0.584
negative regulation of cellular biosynthetic process	GO:0031327	277	0.557
dna conformation change	GO:0071103	105	0.551
mitotic nuclear division	GO:0007067	213	0.545
mitotic g2 m transition checkpoint	GO:0044818	70	0.540
non recombinational repair	GO:0000726	7	0.524
regulation of cell cycle phase transition	GO:1901987	130	0.507
chromosome condensation	GO:0030261	41	0.501
mitotic cell cycle phase transition	GO:0044772	138	0.485
meiotic sister chromatid segregation	GO:0045144	6	0.483
mitotic sister chromatid segregation	GO:0000070	87	0.478
regulation of cell cycle	GO:0051726	291	0.475
meiotic chromosome segregation	GO:0045132	59	0.465
sister chromatid segregation	GO:0000819	92	0.438
spindle midzone assembly	GO:0051255	4	0.422
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.418
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.411
spermatogenesis	GO:0007283	200	0.408
macromolecular complex assembly	GO:0065003	256	0.406
meiotic cytokinesis	GO:0033206	33	0.394
cytoskeleton dependent cytokinesis	GO:0061640	81	0.387
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.354
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.346
negative regulation of microtubule polymerization or depolymerization	GO:0031111	21	0.341
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.336
mitotic g2 dna damage checkpoint	GO:0007095	69	0.331
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.329
dna metabolic process	GO:0006259	227	0.315
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.299
mitotic cell cycle checkpoint	GO:0007093	88	0.292
spindle assembly involved in mitosis	GO:0090307	50	0.289
establishment of spindle orientation	GO:0051294	18	0.284
protein complex biogenesis	GO:0070271	201	0.277
organelle localization	GO:0051640	148	0.276
pronuclear migration	GO:0035046	4	0.273
female meiotic division	GO:0007143	70	0.270
cellular component disassembly	GO:0022411	46	0.259
embryo development ending in birth or egg hatching	GO:0009792	152	0.256	Worm
microtubule polymerization or depolymerization	GO:0031109	39	0.250
cell cycle phase transition	GO:0044770	140	0.239
dna packaging	GO:0006323	91	0.228
asymmetric cell division	GO:0008356	37	0.227
negative regulation of cell cycle process	GO:0010948	109	0.223
nucleus localization	GO:0051647	34	0.221
negative regulation of cell cycle phase transition	GO:1901988	103	0.219
single fertilization	GO:0007338	24	0.210
negative regulation of g2 m transition of mitotic cell cycle	GO:0010972	8	0.205
regulation of dna repair	GO:0006282	5	0.202
regulation of spindle organization	GO:0090224	17	0.193
microtubule organizing center organization	GO:0031023	168	0.189
spermatid differentiation	GO:0048515	114	0.188
regulation of organelle organization	GO:0033043	196	0.187
positive regulation of macromolecule metabolic process	GO:0010604	405	0.174
reciprocal meiotic recombination	GO:0007131	19	0.174
mitotic dna integrity checkpoint	GO:0044774	75	0.171
regulation of cell cycle process	GO:0010564	181	0.171
pronuclear fusion	GO:0007344	4	0.170
establishment of cell polarity	GO:0030010	40	0.170
regulation of cytoskeleton organization	GO:0051493	89	0.169
regulation of mitotic spindle organization	GO:0060236	9	0.167
regulation of protein metabolic process	GO:0051246	256	0.164
negative regulation of mitotic cell cycle	GO:0045930	109	0.159
negative regulation of biosynthetic process	GO:0009890	277	0.149
membrane disassembly	GO:0030397	4	0.145
establishment of nucleus localization	GO:0040023	26	0.144
negative regulation of cell cycle	GO:0045786	116	0.142
spermatid development	GO:0007286	98	0.140
nucleus organization	GO:0006997	45	0.140
positive regulation of cellular protein metabolic process	GO:0032270	118	0.135
mitotic spindle stabilization	GO:0043148	6	0.134
negative regulation of cellular component organization	GO:0051129	108	0.133
chromosome separation	GO:0051304	42	0.133
syncytial blastoderm mitotic cell cycle	GO:0035186	21	0.132
protein depolymerization	GO:0051261	31	0.130
nucleoside triphosphate catabolic process	GO:0009143	108	0.129
establishment or maintenance of cell polarity	GO:0007163	167	0.129
negative regulation of rna biosynthetic process	GO:1902679	240	0.128
negative regulation of rna metabolic process	GO:0051253	251	0.122
regulation of chromosome segregation	GO:0051983	32	0.122
oocyte maturation	GO:0001556	3	0.121
nucleobase containing compound catabolic process	GO:0034655	165	0.108
negative regulation of gene expression	GO:0010629	387	0.108
establishment of spindle localization	GO:0051293	22	0.108
spindle elongation	GO:0051231	83	0.107
karyogamy	GO:0000741	4	0.105
mitotic sister chromatid separation	GO:0051306	30	0.102
protein localization	GO:0008104	284	0.101
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.094
regulation of protein complex disassembly	GO:0043244	29	0.094
dna recombination	GO:0006310	32	0.093
female meiosis i	GO:0007144	8	0.091
cell cycle checkpoint	GO:0000075	95	0.090
regulation of microtubule based process	GO:0032886	49	0.087
male gamete generation	GO:0048232	201	0.086
regulation of gene expression epigenetic	GO:0040029	128	0.086
heterocycle catabolic process	GO:0046700	166	0.085
nucleotide metabolic process	GO:0009117	161	0.083
cytokinetic process	GO:0032506	27	0.082
protein complex assembly	GO:0006461	200	0.081
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.079
mitotic chromosome condensation	GO:0007076	22	0.079
protein complex disassembly	GO:0043241	36	0.077
regulation of meiosis	GO:0040020	3	0.076
cellular protein complex assembly	GO:0043623	71	0.076
posttranscriptional gene silencing by rna	GO:0035194	45	0.076
negative regulation of cell cycle g2 m phase transition	GO:1902750	8	0.075
regulation of mitotic cell cycle	GO:0007346	190	0.072
metaphase anaphase transition of cell cycle	GO:0044784	28	0.072
regulation of mitosis	GO:0007088	56	0.072
centrosome separation	GO:0051299	20	0.067
cellular component assembly involved in morphogenesis	GO:0010927	151	0.067
centrosome cycle	GO:0007098	137	0.067
microtubule anchoring	GO:0034453	11	0.066
establishment of localization in cell	GO:0051649	402	0.063
g2 m transition of mitotic cell cycle	GO:0000086	19	0.063
mrna metabolic process	GO:0016071	124	0.062
negative regulation of transcription dna templated	GO:0045892	237	0.061
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.059
dna damage checkpoint	GO:0000077	78	0.058
dna double strand break processing	GO:0000729	3	0.056
regulation of cell development	GO:0060284	215	0.055
meiotic sister chromatid cohesion	GO:0051177	6	0.054
nuclear migration	GO:0007097	20	0.052
regulation of mitotic spindle elongation	GO:0032888	1	0.052
microtubule polymerization	GO:0046785	15	0.052
protein polymerization	GO:0051258	42	0.052
regulation of dna metabolic process	GO:0051052	34	0.051
atp metabolic process	GO:0046034	49	0.051
regulation of cell division	GO:0051302	72	0.049
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.049
microtubule depolymerization	GO:0007019	25	0.049
regulation of mitotic sister chromatid separation	GO:0010965	28	0.047
negative regulation of mitotic sister chromatid separation	GO:2000816	13	0.046
regulation of cellular protein metabolic process	GO:0032268	243	0.046
cellular macromolecular complex assembly	GO:0034622	153	0.046
regulation of nuclear division	GO:0051783	58	0.046
regulation of catalytic activity	GO:0050790	185	0.045
positive regulation of metaphase anaphase transition of cell cycle	GO:1902101	10	0.045
regulation of spindle elongation	GO:0032887	1	0.045
cellular protein modification process	GO:0006464	438	0.044
cellular response to dna damage stimulus	GO:0006974	223	0.043
negative regulation of chromosome organization	GO:2001251	19	0.041
mitotic spindle elongation	GO:0000022	81	0.039
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.039
spindle localization	GO:0051653	22	0.039
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.039
mitotic cell cycle embryonic	GO:0045448	38	0.038
male meiosis chromosome segregation	GO:0007060	10	0.037
dna integrity checkpoint	GO:0031570	81	0.037
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.037
positive regulation of mitotic metaphase anaphase transition	GO:0045842	10	0.037
extracellular structure organization	GO:0043062	46	0.037
body morphogenesis	GO:0010171	2	0.036
cellular catabolic process	GO:0044248	372	0.036
catabolic process	GO:0009056	409	0.035
double strand break repair	GO:0006302	26	0.035
g2 dna damage checkpoint	GO:0031572	69	0.034
modification dependent macromolecule catabolic process	GO:0043632	79	0.033
regulation of sister chromatid segregation	GO:0033045	28	0.032
aromatic compound catabolic process	GO:0019439	166	0.032
dna repair	GO:0006281	54	0.031
single organism cellular localization	GO:1902580	180	0.031
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.031
telomere maintenance	GO:0000723	21	0.030
cell cycle g2 m phase transition	GO:0044839	22	0.030
negative regulation of signal transduction by p53 class mediator	GO:1901797	1	0.030
ribonucleoside catabolic process	GO:0042454	112	0.030
regulation of developmental growth	GO:0048638	174	0.029
nucleoside catabolic process	GO:0009164	112	0.029
central nervous system development	GO:0007417	201	0.029
cellular macromolecule catabolic process	GO:0044265	136	0.028
positive regulation of cell proliferation	GO:0008284	47	0.028
forebrain development	GO:0030900	2	0.028
ribonucleotide metabolic process	GO:0009259	145	0.028
regulation of cell size	GO:0008361	63	0.028
mitotic cytokinesis	GO:0000281	50	0.028
mrna processing	GO:0006397	104	0.028
negative regulation of cell division	GO:0051782	17	0.026
single organism catabolic process	GO:0044712	228	0.026
positive regulation of mitotic sister chromatid separation	GO:1901970	10	0.026
maintenance of location	GO:0051235	73	0.026
sister chromatid cohesion	GO:0007062	18	0.026
establishment of mitotic spindle localization	GO:0040001	17	0.025
nucleoside phosphate metabolic process	GO:0006753	162	0.025
regulation of neuron differentiation	GO:0045664	103	0.024
organophosphate metabolic process	GO:0019637	195	0.024
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.024
mrna 3 end processing	GO:0031124	28	0.024
protein modification process	GO:0036211	438	0.024
cellular nitrogen compound catabolic process	GO:0044270	165	0.024
regulation of protein catabolic process	GO:0042176	55	0.024
maintenance of protein location in cell	GO:0032507	26	0.023
oocyte development	GO:0048599	124	0.023
centriole replication	GO:0007099	24	0.023
establishment of meiotic spindle orientation	GO:0051296	2	0.023
negative regulation of cell differentiation	GO:0045596	143	0.023
head development	GO:0060322	135	0.023
oocyte differentiation	GO:0009994	145	0.022
cellular macromolecule localization	GO:0070727	220	0.022
mitotic spindle assembly checkpoint	GO:0007094	11	0.022
muscle cell differentiation	GO:0042692	103	0.022
positive regulation of proteolysis	GO:0045862	52	0.021
posttranscriptional regulation of gene expression	GO:0010608	145	0.021
nucleoside metabolic process	GO:0009116	127	0.021
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.021
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.021
regulation of establishment of protein localization	GO:0070201	61	0.021
golgi organization	GO:0007030	66	0.021
muscle structure development	GO:0061061	224	0.021
negative regulation of mitotic metaphase anaphase transition	GO:0045841	13	0.021
purine ribonucleotide catabolic process	GO:0009154	109	0.021
mitotic dna damage checkpoint	GO:0044773	74	0.021
protein phosphorylation	GO:0006468	169	0.020
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.020
positive regulation of rna metabolic process	GO:0051254	271	0.020
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.020
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.020
organic substance catabolic process	GO:1901575	308	0.020
negative regulation of protein metabolic process	GO:0051248	85	0.020
meiotic chromosome separation	GO:0051307	8	0.019
energy derivation by oxidation of organic compounds	GO:0015980	32	0.019
regulation of reproductive process	GO:2000241	54	0.019
developmental maturation	GO:0021700	172	0.019
chromosome organization involved in meiosis	GO:0070192	10	0.019
appendage morphogenesis	GO:0035107	397	0.019
negative regulation of cell development	GO:0010721	62	0.018
negative regulation of protein depolymerization	GO:1901880	23	0.018
tube development	GO:0035295	244	0.018
nucleobase containing small molecule metabolic process	GO:0055086	174	0.018
mitotic spindle checkpoint	GO:0071174	11	0.018
positive regulation of cellular biosynthetic process	GO:0031328	316	0.018
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.018
purine nucleotide metabolic process	GO:0006163	146	0.018
gland development	GO:0048732	191	0.017
dna geometric change	GO:0032392	16	0.017
centrosome organization	GO:0051297	163	0.017
post embryonic appendage morphogenesis	GO:0035120	385	0.017
chromatin silencing	GO:0006342	76	0.017
establishment of mitotic spindle orientation	GO:0000132	13	0.017
regulation of embryonic development	GO:0045995	68	0.017
telomere organization	GO:0032200	21	0.017
regulation of proteolysis	GO:0030162	87	0.017
positive regulation of protein catabolic process	GO:0045732	34	0.017
anatomical structure homeostasis	GO:0060249	97	0.016
negative regulation of gene expression epigenetic	GO:0045814	77	0.016
nuclear envelope organization	GO:0006998	7	0.016
axonogenesis	GO:0007409	290	0.016
protein catabolic process	GO:0030163	101	0.016
positive regulation of catalytic activity	GO:0043085	118	0.016
negative regulation of transposition	GO:0010529	12	0.016
positive regulation of catabolic process	GO:0009896	105	0.016
macromolecular complex disassembly	GO:0032984	37	0.016
nucleoside monophosphate metabolic process	GO:0009123	52	0.016
negative regulation of cellular catabolic process	GO:0031330	34	0.016
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.016
regulation of cell differentiation	GO:0045595	302	0.016
regulation of multicellular organismal development	GO:2000026	414	0.016
purine ribonucleotide metabolic process	GO:0009150	145	0.016
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.015
organic cyclic compound catabolic process	GO:1901361	168	0.015
regulation of chromatin silencing	GO:0031935	36	0.015
regulation of protein complex assembly	GO:0043254	42	0.015
purine containing compound metabolic process	GO:0072521	155	0.015
cytoplasmic microtubule organization	GO:0031122	22	0.015
cell maturation	GO:0048469	144	0.015
negative regulation of cellular protein metabolic process	GO:0032269	85	0.015
regulation of cell proliferation	GO:0042127	163	0.015
positive regulation of protein metabolic process	GO:0051247	128	0.015
mitotic centrosome separation	GO:0007100	8	0.015
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.014
ribose phosphate metabolic process	GO:0019693	145	0.014
cell proliferation	GO:0008283	299	0.014
spindle checkpoint	GO:0031577	11	0.014
nucleoside triphosphate metabolic process	GO:0009141	120	0.014
regulation of localization	GO:0032879	275	0.014
wing disc pattern formation	GO:0035222	66	0.014
wing disc morphogenesis	GO:0007472	344	0.014
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.014
regulation of protein polymerization	GO:0032271	28	0.014
regulation of protein localization	GO:0032880	76	0.014
neuron projection guidance	GO:0097485	241	0.014
chromosome localization	GO:0050000	20	0.014
positive regulation of gene expression	GO:0010628	290	0.014
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.013
regulation of neural precursor cell proliferation	GO:2000177	35	0.013
sex determination	GO:0007530	18	0.013
establishment of organelle localization	GO:0051656	122	0.013
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.013
regulation of cellular protein catabolic process	GO:1903362	44	0.013
positive regulation of nervous system development	GO:0051962	69	0.013
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.013
regulation of transcription from rna polymerase i promoter	GO:0006356	4	0.013
actin cytoskeleton organization	GO:0030036	206	0.013
atp dependent chromatin remodeling	GO:0043044	22	0.013
nucleoside monophosphate catabolic process	GO:0009125	39	0.013
sex differentiation	GO:0007548	81	0.013	Worm
regulation of dna recombination	GO:0000018	4	0.012
regulation of chromosome organization	GO:0033044	64	0.012
regulation of cell maturation	GO:1903429	27	0.012
telencephalon development	GO:0021537	2	0.012
assembly of actomyosin apparatus involved in cytokinesis	GO:0000912	11	0.012
spindle stabilization	GO:0043146	14	0.012
dorsal ventral pattern formation	GO:0009953	133	0.012
single organism biosynthetic process	GO:0044711	206	0.012
macromolecule catabolic process	GO:0009057	161	0.012
meiotic chromosome condensation	GO:0010032	3	0.012
negative regulation of metaphase anaphase transition of cell cycle	GO:1902100	13	0.012
double strand break repair via synthesis dependent strand annealing	GO:0045003	6	0.012
embryonic cleavage	GO:0040016	5	0.012
negative regulation of mitotic sister chromatid segregation	GO:0033048	13	0.012
negative regulation of dna metabolic process	GO:0051053	12	0.012
response to abiotic stimulus	GO:0009628	341	0.011
negative regulation of developmental process	GO:0051093	201	0.011
cellular protein localization	GO:0034613	160	0.011
chromatin assembly or disassembly	GO:0006333	52	0.011
actin filament based process	GO:0030029	220	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.011
negative regulation of cyclin dependent protein serine threonine kinase activity	GO:0045736	1	0.011
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.011
regulation of dna replication	GO:0006275	13	0.011
imaginal disc derived appendage development	GO:0048737	399	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.011
dna catabolic process exonucleolytic	GO:0000738	8	0.011
dna catabolic process	GO:0006308	16	0.011
negative regulation of cytoskeleton organization	GO:0051494	30	0.011
regulation of microtubule depolymerization	GO:0031114	24	0.011
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.011
cell death	GO:0008219	279	0.011
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.011
organophosphate catabolic process	GO:0046434	112	0.011
cellular protein complex disassembly	GO:0043624	35	0.010
lateral inhibition	GO:0046331	206	0.010
negative regulation of organelle organization	GO:0010639	56	0.010
respiratory system development	GO:0060541	213	0.010
positive regulation of chromosome segregation	GO:0051984	10	0.010
tube morphogenesis	GO:0035239	191	0.010
endomembrane system organization	GO:0010256	119	0.010
vesicle mediated transport	GO:0016192	381	0.010	Worm
positive regulation of phosphate metabolic process	GO:0045937	139	0.010
positive regulation of cell death	GO:0010942	69	0.010
positive regulation of binding	GO:0051099	4	0.010
rna 3 end processing	GO:0031123	45	0.010

Klp3A disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.012
benign neoplasm	DOID:0060072	0.010
disease of cellular proliferation	DOID:14566	0.010

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