Drosophila melanogaster

140 known processes

CSN4 (Dmel_CG8725)

COP9 complex homolog subunit 4

(Aliases: CG8725,csn4,l(2)k08018,Cops4,Csn4,CH4,Dmel\CG8725,DCH4,Dch4)

CSN4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cullin deneddylationGO:001038831.000
protein deneddylationGO:000033880.998
protein modification by small protein removalGO:0070646280.978
chromosome organizationGO:00512763600.956
cellular response to dna damage stimulusGO:00069742230.949
mitotic dna damage checkpointGO:0044773740.882
protein modification by small protein conjugation or removalGO:00706471060.835
embryo development ending in birth or egg hatchingGO:00097921520.831
Worm
cell divisionGO:00513012480.777
Worm
response to abiotic stimulusGO:00096283410.767
dna damage checkpointGO:0000077780.737
post embryonic hemopoiesisGO:0035166170.688
mitotic g2 m transition checkpointGO:0044818700.674
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434370.602
regulation of cellular component biogenesisGO:00440872010.579
asymmetric stem cell divisionGO:0098722490.537
cell cycle checkpointGO:0000075950.501
localization of cellGO:00516742570.499
female germ line stem cell asymmetric divisionGO:0048132140.466
mitotic dna integrity checkpointGO:0044774750.460
regulation of catabolic processGO:00098941700.452
cell motilityGO:00488702510.446
g2 dna damage checkpointGO:0031572690.431
negative regulation of lamellocyte differentiationGO:003520450.424
negative regulation of cell cycle phase transitionGO:19019881030.422
negative regulation of developmental processGO:00510932010.405
mitotic g2 dna damage checkpointGO:0007095690.380
regulation of multi organism processGO:00439001310.367
cell proliferationGO:00082832990.362
mitotic cell cycle checkpointGO:0007093880.361
cellular protein modification processGO:00064644380.357
chromatin modificationGO:00165681470.349
germline stem cell asymmetric divisionGO:0098728150.347
neurological system processGO:00508773580.333
negative regulation of mitotic cell cycleGO:00459301090.313
cytokinesisGO:0000910900.310
Worm
regulation of proteasomal protein catabolic processGO:0061136390.306
single organism biosynthetic processGO:00447112060.304
protein modification processGO:00362114380.302
cell migrationGO:00164772380.300
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436190.300
negative regulation of cell cycle processGO:00109481090.289
double strand break repairGO:0006302260.288
response to light stimulusGO:00094161240.282
columnar cuboidal epithelial cell differentiationGO:00020652560.268
positive regulation of proteasomal protein catabolic processGO:1901800200.267
negative regulation of cell cycleGO:00457861160.264
dna repairGO:0006281540.263
cuticle pigmentationGO:0048067220.252
negative regulation of mitotic cell cycle phase transitionGO:19019911030.235
organonitrogen compound metabolic processGO:19015643180.231
regulation of notch signaling pathwayGO:00085931000.224
regulation of neurogenesisGO:00507671580.224
regulation of cellular protein catabolic processGO:1903362440.213
germ line stem cell divisionGO:0042078250.211
cellular catabolic processGO:00442483720.204
response to organic substanceGO:00100332840.196
regionalizationGO:00030024160.189
macromolecule catabolic processGO:00090571610.183
response to radiationGO:00093141550.183
positive regulation of biosynthetic processGO:00098913160.177
regulation of multicellular organismal developmentGO:20000264140.176
dorsal ventral axis specificationGO:0009950660.168
proteasomal protein catabolic processGO:0010498590.165
positive regulation of nitrogen compound metabolic processGO:00511733540.156
negative regulation of transcription dna templatedGO:00458922370.148
lateral inhibitionGO:00463312060.133
regulation of epithelial cell proliferationGO:005067840.131
dna templated transcription initiationGO:0006352250.130
small molecule metabolic processGO:00442813050.130
morphogenesis of an epitheliumGO:00020092760.128
deathGO:00162652840.124
larval lymph gland hemopoiesisGO:0035167170.123
nuclear divisionGO:00002803320.122
regulation of protein metabolic processGO:00512462560.122
agingGO:00075681430.119
hematopoietic or lymphoid organ developmentGO:0048534570.118
immune system processGO:00023763470.116
protein catabolic processGO:00301631010.115
proteolysis involved in cellular protein catabolic processGO:0051603830.115
positive regulation of cellular component organizationGO:00511301560.114
catabolic processGO:00090564090.110
negative regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032435160.108
regulation of synapse organizationGO:00508071100.107
cell cycle phase transitionGO:00447701400.107
protein localization to nucleusGO:0034504550.107
regulation of cellular protein metabolic processGO:00322682430.107
enzyme linked receptor protein signaling pathwayGO:00071671790.106
protein localization to organelleGO:0033365820.104
programmed cell deathGO:00125012570.103
protein phosphorylationGO:00064681690.103
apoptotic processGO:00069151590.102
organic acid metabolic processGO:00060821030.102
positive regulation of proteolysisGO:0045862520.098
positive regulation of protein metabolic processGO:00512471280.096
hemocyte differentiationGO:0042386380.093
positive regulation of rna biosynthetic processGO:19026802660.092
oxoacid metabolic processGO:00434361030.091
regulation of phosphate metabolic processGO:00192202100.090
regulation of cell deathGO:00109411730.090
regulation of nervous system developmentGO:00519602480.088
organonitrogen compound biosynthetic processGO:19015661170.088
developmental pigmentationGO:0048066680.087
covalent chromatin modificationGO:00165691060.087
negative regulation of cell differentiationGO:00455961430.086
cellular protein catabolic processGO:0044257830.086
stem cell divisionGO:0017145690.086
positive regulation of cellular component biogenesisGO:0044089800.086
negative regulation of immune system processGO:0002683500.086
cellular response to abiotic stimulusGO:0071214580.085
lipid biosynthetic processGO:0008610460.084
vesicle mediated transportGO:00161923810.081
hemopoiesisGO:0030097460.080
germ line stem cell maintenanceGO:0030718500.080
neuroblast proliferationGO:0007405740.079
regulation of protein modification processGO:00313991120.078
lymph gland developmentGO:0048542280.078
oocyte dorsal ventral axis specificationGO:0007310340.077
negative regulation of cell communicationGO:00106482230.076
positive regulation of phosphate metabolic processGO:00459371390.075
pigmentationGO:0043473750.075
columnar cuboidal epithelial cell developmentGO:00020662490.075
histone modificationGO:00165701060.074
larval lymph gland hemocyte differentiationGO:0035168110.074
stem cell proliferationGO:0072089880.074
negative regulation of post embryonic developmentGO:004858150.073
positive regulation of signalingGO:00230562430.073
regulation of cell differentiationGO:00455953020.071
dna integrity checkpointGO:0031570810.071
negative regulation of peptidyl tyrosine phosphorylationGO:005073260.071
negative regulation of proteasomal protein catabolic processGO:1901799160.069
sister chromatid segregationGO:0000819920.066
spermatogenesisGO:00072832000.065
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.065
cellular macromolecule catabolic processGO:00442651360.064
negative regulation of rna biosynthetic processGO:19026792400.061
ncrna metabolic processGO:0034660430.061
organic substance catabolic processGO:19015753080.061
regulation of cellular catabolic processGO:00313291570.060
phosphorylationGO:00163102940.060
protein localization to plasma membraneGO:0072659130.060
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052240.060
negative regulation of nucleobase containing compound metabolic processGO:00459342610.059
oocyte differentiationGO:00099941450.059
multicellular organismal agingGO:00102591400.058
dendrite developmentGO:00163582040.057
immune system developmentGO:0002520570.057
regulation of protein stabilityGO:0031647430.057
negative regulation of response to stimulusGO:00485852580.057
response to oxygen containing compoundGO:19017002000.056
negative regulation of cellular metabolic processGO:00313243820.056
ubiquitin dependent protein catabolic processGO:0006511780.055
regulation of molecular functionGO:00650092170.055
posttranscriptional regulation of gene expressionGO:00106081450.055
positive regulation of protein catabolic processGO:0045732340.055
negative regulation of cellular catabolic processGO:0031330340.054
response to biotic stimulusGO:00096072940.054
transcription from rna polymerase ii promoterGO:00063663680.053
cell maturationGO:00484691440.053
regulation of mitotic cell cycle phase transitionGO:19019901300.053
negative regulation of macromolecule biosynthetic processGO:00105582700.053
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.053
positive regulation of gene expressionGO:00106282900.052
negative regulation of nitrogen compound metabolic processGO:00511722650.052
male gamete generationGO:00482322010.051
modification dependent protein catabolic processGO:0019941780.050
cell deathGO:00082192790.050
mitotic nuclear divisionGO:00070672130.050
proteolysisGO:00065081920.049
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.049
negative regulation of cellular protein metabolic processGO:0032269850.048
regulation of phosphorus metabolic processGO:00511742100.048
negative regulation of nucleic acid templated transcriptionGO:19035072400.048
interspecies interaction between organismsGO:0044419160.048
regulation of cellular ketone metabolic processGO:001056530.048
positive regulation of macromolecule biosynthetic processGO:00105572830.048
axon developmentGO:00615642970.047
negative regulation of phosphate metabolic processGO:0045936450.046
regulation of membrane potentialGO:0042391350.046
regulation of protein complex assemblyGO:0043254420.045
chemotaxisGO:00069352490.045
positive regulation of nucleobase containing compound metabolic processGO:00459353320.044
ovarian follicle cell developmentGO:00307072480.044
negative regulation of multicellular organismal processGO:00512411420.044
modification dependent macromolecule catabolic processGO:0043632790.043
regulation of cellular amine metabolic processGO:003323830.042
negative regulation of cellular component organizationGO:00511291080.042
negative regulation of cellular biosynthetic processGO:00313272770.041
positive regulation of cellular protein catabolic processGO:1903364240.041
positive regulation of cellular biosynthetic processGO:00313283160.041
developmental growthGO:00485892800.041
ion transportGO:00068111450.040
carboxylic acid metabolic processGO:0019752920.040
regulation of programmed cell deathGO:00430671520.039
eye developmentGO:00016543230.039
regulation of lamellocyte differentiationGO:003520360.038
molting cycle processGO:0022404290.038
multicellular organismal reproductive behaviorGO:00330571100.038
positive regulation of transcription dna templatedGO:00458932660.038
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.038
regulation of organelle organizationGO:00330431960.038
sphingolipid metabolic processGO:0006665190.037
regulation of cell proliferationGO:00421271630.037
fertilizationGO:0009566260.036
response to temperature stimulusGO:00092661060.036
lamellocyte differentiationGO:003517190.036
endocytosisGO:00068973100.036
reproductive system developmentGO:0061458740.036
Worm
single organism behaviorGO:00447083910.035
sex differentiationGO:0007548810.035
Worm
positive regulation of phosphorus metabolic processGO:00105621390.034
regulation of transcription from rna polymerase ii promoterGO:00063573780.034
ovipositionGO:0018991190.034
regulation of locomotionGO:0040012420.034
histone h3 k4 methylationGO:0051568160.033
gliogenesisGO:0042063800.033
protein deubiquitinationGO:0016579170.032
exocytosisGO:0006887280.032
negative regulation of autophagyGO:0010507160.032
establishment of organelle localizationGO:00516561220.032
anterior posterior axis specification embryoGO:00085951030.032
endomembrane system organizationGO:00102561190.032
protein ubiquitinationGO:0016567700.032
chromatin remodelingGO:0006338720.031
protein complex assemblyGO:00064612000.031
regulation of mitotic cell cycleGO:00073461900.031
regulation of response to external stimulusGO:00321011150.031
dna metabolic processGO:00062592270.031
locomotory behaviorGO:00076261760.031
synapse organizationGO:00508081960.031
glial cell migrationGO:0008347310.031
carbohydrate derivative biosynthetic processGO:1901137850.030
meiotic cell cycleGO:00513211710.030
regulation of anatomical structure morphogenesisGO:00226032420.030
regulation of proteolysisGO:0030162870.030
regulation of intracellular signal transductionGO:19025312360.030
larval developmentGO:00021641040.030
Worm
cuticle developmentGO:0042335860.030
ribonucleoside triphosphate catabolic processGO:00092031080.030
positive regulation of developmental processGO:00510941430.030
cellular response to chemical stimulusGO:00708871990.029
oocyte developmentGO:00485991240.029
determination of adult lifespanGO:00083401370.029
eye morphogenesisGO:00485922600.029
positive regulation of nervous system developmentGO:0051962690.029
epithelium migrationGO:00901321480.029
positive regulation of macromolecule metabolic processGO:00106044050.029
cellular macromolecule localizationGO:00707272200.029
purine nucleoside catabolic processGO:00061521120.028
negative regulation of nervous system developmentGO:0051961920.028
negative regulation of cell proliferationGO:0008285690.028
lipid metabolic processGO:00066291210.028
regulation of cell morphogenesisGO:00226041630.028
regulation of phosphorylationGO:00423251470.028
apposition of dorsal and ventral imaginal disc derived wing surfacesGO:0007475150.027
muscle organ developmentGO:00075171270.027
guanosine containing compound metabolic processGO:1901068740.027
regulation of cell cycleGO:00517262910.027
dorsal ventral pattern formationGO:00099531330.027
negative regulation of signalingGO:00230572190.026
protein localizationGO:00081042840.026
hematopoietic progenitor cell differentiationGO:000224410.026
regulation of catalytic activityGO:00507901850.026
carbohydrate metabolic processGO:0005975820.025
dna templated transcriptional preinitiation complex assemblyGO:0070897200.025
regulation of kinase activityGO:0043549530.025
regulation of protein kinase activityGO:0045859510.025
secretion by cellGO:00329401010.025
eye photoreceptor cell differentiationGO:00017541450.025
homeostatic processGO:00425921990.025
negative regulation of protein metabolic processGO:0051248850.025
regulation of developmental growthGO:00486381740.025
chromatin silencingGO:0006342760.025
reproductive structure developmentGO:0048608740.025
Worm
glycosyl compound metabolic processGO:19016571270.024
cellular ketone metabolic processGO:0042180240.024
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051170.024
cellular amino acid metabolic processGO:0006520610.024
golgi to plasma membrane transportGO:000689380.024
regulation of lipid metabolic processGO:0019216150.024
positive regulation of cell communicationGO:00106472500.024
mitotic cytokinesisGO:0000281500.023
regulation of synapse structure and activityGO:00508031280.023
notch signaling pathwayGO:00072191200.023
stem cell maintenanceGO:0019827670.023
negative regulation of cell deathGO:0060548810.022
regulation of response to stressGO:00801342000.022
protein polyubiquitinationGO:0000209110.022
rna localizationGO:00064031150.022
cognitionGO:00508901410.022
positive regulation of histone deacetylationGO:003106520.022
germarium derived egg chamber formationGO:00072931010.022
positive regulation of intracellular signal transductionGO:19025331160.021
negative regulation of transferase activityGO:0051348180.021
negative regulation of rna metabolic processGO:00512532510.021
regulation of transferase activityGO:0051338580.021
appendage morphogenesisGO:00351073970.021
camera type eye developmentGO:004301040.021
positive regulation of signal transductionGO:00099672230.021
regulation of autophagyGO:0010506620.021
membrane organizationGO:00610241120.021
carbohydrate derivative metabolic processGO:19011352170.021
ovarian follicle cell migrationGO:00072971210.021
actin cytoskeleton organizationGO:00300362060.020
regulation of neuron differentiationGO:00456641030.020
kidney developmentGO:000182230.020
response to extracellular stimulusGO:00099911160.020
nitrogen compound transportGO:0071705850.020
regulation of epidermal growth factor receptor signaling pathwayGO:0042058420.020
cellular protein localizationGO:00346131600.020
secondary metabolic processGO:0019748750.020
cellular nitrogen compound catabolic processGO:00442701650.020
regulation of hydrolase activityGO:0051336970.019
epidermal growth factor receptor signaling pathwayGO:0007173580.019
golgi to plasma membrane protein transportGO:004300180.019
regulation of post embryonic developmentGO:0048580100.019
negative regulation of catabolic processGO:0009895360.019
multi organism reproductive behaviorGO:00447051210.019
positive regulation of protein complex assemblyGO:0031334220.019
stem cell differentiationGO:00488631170.019
purine nucleotide metabolic processGO:00061631460.019
regulation of cellular amino acid metabolic processGO:000652100.019
nucleobase containing small molecule metabolic processGO:00550861740.019
positive regulation of catabolic processGO:00098961050.019
single organism carbohydrate metabolic processGO:0044723720.018
photoreceptor cell differentiationGO:00465301700.018
response to external biotic stimulusGO:00432072930.018
neuron fate commitmentGO:0048663500.018
phagocytosisGO:00069092150.018
actin filament based processGO:00300292200.018
regulation of gene expression epigeneticGO:00400291280.018
autophagyGO:00069141080.018
meiotic nuclear divisionGO:00071261510.018
defense response to other organismGO:00985422250.018
histone h2a acetylationGO:004396810.018
cell adhesionGO:00071551360.018
protein acylationGO:0043543420.017
protein modification by small protein conjugationGO:0032446790.017
negative regulation of neural precursor cell proliferationGO:2000178270.017
stem cell developmentGO:0048864790.017
pigment biosynthetic processGO:0046148360.017
negative regulation of phosphorus metabolic processGO:0010563450.017
karyosome formationGO:0030717220.017
purine nucleoside metabolic processGO:00422781270.017
chaeta developmentGO:0022416970.017
positive regulation of protein modification processGO:0031401580.017
regulation of localizationGO:00328792750.016
anatomical structure homeostasisGO:0060249970.016
regulation of chromosome organizationGO:0033044640.016
positive regulation of response to stimulusGO:00485843230.016
organelle fissionGO:00482853400.016
molting cycleGO:0042303560.016
axon target recognitionGO:0007412160.016
rna processingGO:00063961470.016
cellular amide metabolic processGO:0043603800.016
blastoderm segmentationGO:00073501590.016
regulation of establishment of protein localizationGO:0070201610.016
cytoskeleton dependent cytokinesisGO:0061640810.016
establishment of localization in cellGO:00516494020.016
purine ribonucleotide metabolic processGO:00091501450.016
regulation of protein localizationGO:0032880760.015
response to other organismGO:00517072930.015
negative regulation of programmed cell deathGO:0043069720.015
regulation of cellular localizationGO:00603411360.015
regulation of reactive oxygen species metabolic processGO:200037780.015
protein maturationGO:0051604710.015
single organism nuclear importGO:1902593510.015
developmental maturationGO:00217001720.015
nuclear transportGO:0051169720.015
neural precursor cell proliferationGO:0061351750.015
ncrna processingGO:0034470300.015
positive regulation of cellular protein metabolic processGO:00322701180.015
positive regulation of multicellular organismal processGO:00512401430.015
imaginal disc derived wing morphogenesisGO:00074763370.015
ameboidal type cell migrationGO:00016671510.015
positive regulation of lipid biosynthetic processGO:004688930.015
toll signaling pathwayGO:0008063250.014
macromolecular complex assemblyGO:00650032560.014
negative regulation of protein maturationGO:1903318310.014
retina development in camera type eyeGO:006004140.014
establishment of spindle localizationGO:0051293220.014
cellular response to external stimulusGO:0071496660.014
nuclear body organizationGO:003057560.014
mapk cascadeGO:00001651070.014
development of primary sexual characteristicsGO:0045137500.014
Worm
spindle localizationGO:0051653220.014
mitotic cell cycle embryonicGO:0045448380.014
rna polymerase ii transcriptional preinitiation complex assemblyGO:0051123200.014
small gtpase mediated signal transductionGO:0007264880.014
gland developmentGO:00487321910.014
negative regulation of protein modification processGO:0031400290.014
positive regulation of cellular catabolic processGO:0031331950.014
ribose phosphate metabolic processGO:00196931450.014
response to bacteriumGO:00096171980.014
negative regulation of defense responseGO:0031348350.014
plasmatocyte differentiationGO:0042387120.014
purine containing compound catabolic processGO:00725231120.014
negative regulation of biosynthetic processGO:00098902770.013
single organism cellular localizationGO:19025801800.013
establishment of protein localization to organelleGO:0072594620.013
negative regulation of sister chromatid segregationGO:0033046130.013
terminal button organizationGO:0072553190.013
adult locomotory behaviorGO:0008344760.013
heterocycle catabolic processGO:00467001660.013
detection of stimulusGO:00516061560.013
negative regulation of epidermal growth factor receptor signaling pathwayGO:0042059290.013
regulation of apoptotic processGO:00429811300.013
sensory organ morphogenesisGO:00905962600.013
regulation of protein phosphorylationGO:0001932640.013
negative regulation of cell divisionGO:0051782170.013
spermatid differentiationGO:00485151140.013
ribonucleotide catabolic processGO:00092611090.013
negative regulation of kinase activityGO:0033673160.013
amine metabolic processGO:0009308120.013
positive regulation of reactive oxygen species metabolic processGO:200037900.013
cell cell signaling involved in cell fate commitmentGO:00451682100.013
positive regulation of protein transportGO:0051222370.013
oxidation reduction processGO:00551141230.013
positive regulation of cell proliferationGO:0008284470.012
carbohydrate derivative catabolic processGO:19011361180.012
negative regulation of phosphorylationGO:0042326350.012
tissue morphogenesisGO:00487292970.012
organic cyclic compound catabolic processGO:19013611680.012
apoptotic cell clearanceGO:0043277140.012
multicellular organismal signalingGO:0035637120.012
peptidyl lysine trimethylationGO:001802360.012
negative regulation of protein processingGO:0010955310.012
regulation of cell developmentGO:00602842150.012
ncrna 3 end processingGO:0043628170.012
cellular response to carbohydrate stimulusGO:007132240.012
epithelial cell migrationGO:00106311480.012
nucleus organizationGO:0006997450.012
chemosensory behaviorGO:00076351060.012
chitin based cuticle developmentGO:0040003490.012
positive regulation of hydrolase activityGO:0051345780.012
nucleotide metabolic processGO:00091171610.012
peptidyl lysine modificationGO:0018205570.012
cellular macromolecular complex assemblyGO:00346221530.011
response to heatGO:0009408630.011
negative regulation of apoptotic processGO:0043066630.011
germarium derived oocyte differentiationGO:0030706290.011
embryonic development via the syncytial blastodermGO:00017001480.011
negative regulation of epithelial cell proliferationGO:005068040.011
regulation of protein catabolic processGO:0042176550.011
negative regulation of translationGO:0017148280.011
regulation of cell divisionGO:0051302720.011
regulation of behaviorGO:0050795750.011
neuron projection guidanceGO:00974852410.010
regulation of wnt signaling pathwayGO:0030111680.010
regulation of cytoplasmic transportGO:1903649470.010
negative regulation of erbb signaling pathwayGO:1901185290.010
appendage developmentGO:00487364010.010
meiotic cell cycle processGO:19030461320.010
regulation of dna templated transcription elongationGO:0032784170.010
regulation of i kappab kinase nf kappab signalingGO:004312220.010
regulation of mapk cascadeGO:0043408920.010
transmission of nerve impulseGO:0019226120.010
membrane lipid metabolic processGO:0006643220.010
neuromuscular junction developmentGO:00075281490.010
negative regulation of signal transductionGO:00099682060.010
ceramide metabolic processGO:000667270.010
glycosyl compound catabolic processGO:19016581120.010
negative regulation of growthGO:0045926840.010
regulation of intracellular protein transportGO:0033157460.010

CSN4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.042
disease of cellular proliferationDOID:1456600.023
organ system cancerDOID:005068600.013
cancerDOID:16200.013
nervous system diseaseDOID:86300.012
central nervous system diseaseDOID:33100.010