IMP: Integrative Multi-species Prediction

Drosophila melanogaster

55 known processes

CG8878 (Dmel_CG8878)

CG8878 gene product from transcript CG8878-RA

(Aliases: VRK,Dmel\CG8878,BcDNA:LD23371)

Entrez: 36302
FLYBASE: FBgn0027504
UniProtKB: Q7KMI3

Process Predictions
Disease Predictions

CG8878 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular macromolecule localization	GO:0070727	220	0.281
cell division	GO:0051301	248	0.238
regulation of cell cycle	GO:0051726	291	0.235
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.216
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.195
positive regulation of rna biosynthetic process	GO:1902680	266	0.187
positive regulation of transcription dna templated	GO:0045893	266	0.168
cellular response to dna damage stimulus	GO:0006974	223	0.138	Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.120
transcription from rna polymerase ii promoter	GO:0006366	368	0.109
positive regulation of macromolecule metabolic process	GO:0010604	405	0.107
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.099
positive regulation of cellular biosynthetic process	GO:0031328	316	0.089
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.085
positive regulation of rna metabolic process	GO:0051254	271	0.084
organelle inheritance	GO:0048308	2	0.079	Human
cellular protein modification process	GO:0006464	438	0.079	Human Mouse Worm Fly
protein localization	GO:0008104	284	0.079
establishment of localization in cell	GO:0051649	402	0.071
single organism intracellular transport	GO:1902582	207	0.070
neurological system process	GO:0050877	358	0.063
regulation of cell cycle phase transition	GO:1901987	130	0.062
catabolic process	GO:0009056	409	0.061
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.060
mitotic cell cycle checkpoint	GO:0007093	88	0.060
chromatin organization	GO:0006325	207	0.059	Human Fly
vesicle mediated transport	GO:0016192	381	0.059
morphogenesis of an epithelium	GO:0002009	276	0.058
positive regulation of response to stimulus	GO:0048584	323	0.057
cellular protein localization	GO:0034613	160	0.055
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.053
cellular catabolic process	GO:0044248	372	0.050
lateral inhibition	GO:0046331	206	0.050
regulation of organelle organization	GO:0033043	196	0.047
regulation of catabolic process	GO:0009894	170	0.046
positive regulation of gene expression	GO:0010628	290	0.046
negative regulation of cell cycle phase transition	GO:1901988	103	0.044
regulation of cell proliferation	GO:0042127	163	0.043
protein complex assembly	GO:0006461	200	0.043
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.041
eye development	GO:0001654	323	0.040
formation of a compartment boundary	GO:0060288	4	0.039
regulation of cell cycle process	GO:0010564	181	0.039
regulation of cellular protein metabolic process	GO:0032268	243	0.038
negative regulation of gene expression	GO:0010629	387	0.038
positive regulation of cellular component organization	GO:0051130	156	0.037
single organism behavior	GO:0044708	391	0.037
protein modification process	GO:0036211	438	0.037	Human Mouse Worm Fly
regulation of protein transport	GO:0051223	57	0.036
meiotic nuclear division	GO:0007126	151	0.036	Fly
anterior posterior pattern specification	GO:0009952	136	0.036
axon guidance	GO:0007411	233	0.036
negative regulation of neurotransmitter secretion	GO:0046929	2	0.035
tissue morphogenesis	GO:0048729	297	0.035
cell proliferation	GO:0008283	299	0.034
organic substance transport	GO:0071702	257	0.034
death	GO:0016265	284	0.034
organic substance catabolic process	GO:1901575	308	0.034
chromosome organization	GO:0051276	360	0.031	Human Fly
nuclear transport	GO:0051169	72	0.029
single organism cellular localization	GO:1902580	180	0.029
intracellular transport	GO:0046907	228	0.028
maintenance of location	GO:0051235	73	0.028
negative regulation of cellular biosynthetic process	GO:0031327	277	0.028
regulation of protein metabolic process	GO:0051246	256	0.027
regulation of intracellular transport	GO:0032386	64	0.026
nucleocytoplasmic transport	GO:0006913	72	0.026
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.026
cellular protein catabolic process	GO:0044257	83	0.026
apoptotic process	GO:0006915	159	0.026
regulation of localization	GO:0032879	275	0.026
negative regulation of rna metabolic process	GO:0051253	251	0.026
positive regulation of biosynthetic process	GO:0009891	316	0.025
regulation of mitotic cell cycle	GO:0007346	190	0.025
programmed cell death	GO:0012501	257	0.024
ras protein signal transduction	GO:0007265	88	0.024
positive regulation of neuron projection regeneration	GO:0070572	3	0.023
negative regulation of biosynthetic process	GO:0009890	277	0.023
negative regulation of mitotic cell cycle	GO:0045930	109	0.023
positive regulation of organelle organization	GO:0010638	65	0.023
regulation of cellular catabolic process	GO:0031329	157	0.023
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.022
developmental growth	GO:0048589	280	0.022
endocytosis	GO:0006897	310	0.022
single organism membrane organization	GO:0044802	93	0.022
organonitrogen compound metabolic process	GO:1901564	318	0.021
establishment of protein localization	GO:0045184	163	0.021
salivary gland morphogenesis	GO:0007435	145	0.021
cell death	GO:0008219	279	0.021
g2 dna damage checkpoint	GO:0031572	69	0.021
sensory organ morphogenesis	GO:0090596	260	0.021
regulation of protein catabolic process	GO:0042176	55	0.020
negative regulation of cell cycle process	GO:0010948	109	0.020
cell migration	GO:0016477	238	0.020
embryo development ending in birth or egg hatching	GO:0009792	152	0.019	Worm
camera type eye development	GO:0043010	4	0.019
regulation of protein modification process	GO:0031399	112	0.019
axon development	GO:0061564	297	0.018
chromatin silencing	GO:0006342	76	0.018
regulation of growth	GO:0040008	233	0.018
membrane organization	GO:0061024	112	0.018
growth	GO:0040007	359	0.018
body morphogenesis	GO:0010171	2	0.018
positive regulation of phosphate metabolic process	GO:0045937	139	0.018
regulation of transport	GO:0051049	181	0.018
regulation of apoptotic process	GO:0042981	130	0.017
macromolecule catabolic process	GO:0009057	161	0.017
chromatin modification	GO:0016568	147	0.017	Human Fly
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.017
central nervous system development	GO:0007417	201	0.017
eye morphogenesis	GO:0048592	260	0.017
cellular macromolecule catabolic process	GO:0044265	136	0.016
negative regulation of cell cycle	GO:0045786	116	0.016
negative regulation of protein binding	GO:0032091	1	0.016
regulation of semaphorin plexin signaling pathway	GO:2001260	2	0.016
embryonic development via the syncytial blastoderm	GO:0001700	148	0.016
cellular response to chemical stimulus	GO:0070887	199	0.016	Human Worm
positive regulation of signal transduction	GO:0009967	223	0.016
compound eye morphogenesis	GO:0001745	249	0.015
nucleosome organization	GO:0034728	59	0.015
phagocytosis	GO:0006909	215	0.015
response to external biotic stimulus	GO:0043207	293	0.015
protein ubiquitination	GO:0016567	70	0.015
positive regulation of epidermal growth factor activated receptor activity	GO:0045741	1	0.015
positive regulation of cell communication	GO:0010647	250	0.015
nitric oxide metabolic process	GO:0046209	1	0.015
exocrine system development	GO:0035272	162	0.014
modification dependent protein catabolic process	GO:0019941	78	0.014
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.014
mitotic dna integrity checkpoint	GO:0044774	75	0.014
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.014
multi multicellular organism process	GO:0044706	123	0.014
nucleobase containing compound catabolic process	GO:0034655	165	0.014
gland development	GO:0048732	191	0.014
regulation of cellular component biogenesis	GO:0044087	201	0.014
regulation of hemocyte proliferation	GO:0035206	37	0.014
cytoplasmic transport	GO:0016482	130	0.014
proteolysis	GO:0006508	192	0.014
apoptotic signaling pathway	GO:0097190	27	0.014
protein catabolic process	GO:0030163	101	0.014
nitrogen compound transport	GO:0071705	85	0.013
establishment of tissue polarity	GO:0007164	87	0.013
compound eye development	GO:0048749	307	0.013
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.013
mitotic cell cycle phase transition	GO:0044772	138	0.013
regulation of protein processing	GO:0070613	32	0.013
phosphorylation	GO:0016310	294	0.013
positive regulation of signaling	GO:0023056	243	0.013
response to abiotic stimulus	GO:0009628	341	0.013
nuclear import	GO:0051170	51	0.013
positive regulation of cellular protein metabolic process	GO:0032270	118	0.013
negative regulation of rna biosynthetic process	GO:1902679	240	0.013
protein import	GO:0017038	55	0.013
head development	GO:0060322	135	0.013
positive regulation of protein metabolic process	GO:0051247	128	0.012
regulation of programmed cell death	GO:0043067	152	0.012
spindle organization	GO:0007051	253	0.012	Fly
learning or memory	GO:0007611	141	0.012
hindbrain development	GO:0030902	2	0.012
response to other organism	GO:0051707	293	0.012
reproductive system development	GO:0061458	74	0.012	Worm
dendrite development	GO:0016358	204	0.012
embryonic morphogenesis	GO:0048598	206	0.012
response to biotic stimulus	GO:0009607	294	0.012
protein modification by small protein conjugation	GO:0032446	79	0.012
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.012	Worm
regulation of stem cell differentiation	GO:2000736	14	0.012
ubiquitin dependent protein catabolic process	GO:0006511	78	0.011
multi organism behavior	GO:0051705	175	0.011
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.011
regulation of meiosis	GO:0040020	3	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011
regulation of cell differentiation	GO:0045595	302	0.011
humoral immune response	GO:0006959	117	0.011
reproductive behavior	GO:0019098	122	0.011
aromatic compound catabolic process	GO:0019439	166	0.011
stress granule disassembly	GO:0035617	1	0.011
negative regulation of cellular component organization	GO:0051129	108	0.011
organophosphate metabolic process	GO:0019637	195	0.011
protein complex biogenesis	GO:0070271	201	0.011
organelle assembly	GO:0070925	198	0.011
ribonucleotide metabolic process	GO:0009259	145	0.011
positive regulation of protein modification process	GO:0031401	58	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.010
sex differentiation	GO:0007548	81	0.010	Worm
defense response to bacterium	GO:0042742	178	0.010
neuron projection guidance	GO:0097485	241	0.010
developmental programmed cell death	GO:0010623	138	0.010
positive regulation of phosphorus metabolic process	GO:0010562	139	0.010
regulation of cell death	GO:0010941	173	0.010
amine metabolic process	GO:0009308	12	0.010
positive regulation of developmental growth	GO:0048639	62	0.010
cellular response to nutrient	GO:0031670	1	0.010
regulation of cellular localization	GO:0060341	136	0.010
regulation of molecular function	GO:0065009	217	0.010	Mouse
organic cyclic compound catabolic process	GO:1901361	168	0.010

CG8878 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.038
nervous system disease	DOID:863	0.020
cancer	DOID:162	0.013
central nervous system cancer	DOID:3620	0.013
meningioma	DOID:3565	0.013
familial meningioma	DOID:4586	0.013
organ system cancer	DOID:0050686	0.013
disease of cellular proliferation	DOID:14566	0.013
nervous system cancer	DOID:3093	0.013

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