IMP: Integrative Multi-species Prediction

Drosophila melanogaster

184 known processes

Chc (Dmel_CG9012)

Clathrin heavy chain

(Aliases: l(1)13Fb,CHC,CLH,l(1)G0438,CG9012,Cla,chc,l(1)VI,Dmel\CG9012,D-Chc)

FLYBASE: FBgn0000319
Entrez: 32537
UniProtKB: P29742
UniProtKB: X2JC31

Process Predictions
Disease Predictions

Chc biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
spermatid differentiation	GO:0048515	114	1.000
oocyte development	GO:0048599	124	0.997
sperm individualization	GO:0007291	48	0.992
establishment of organelle localization	GO:0051656	122	0.986
vesicle mediated transport	GO:0016192	381	0.986
cellularization	GO:0007349	90	0.983
germarium derived egg chamber formation	GO:0007293	101	0.972
oocyte differentiation	GO:0009994	145	0.965
spermatid development	GO:0007286	98	0.950
germarium derived female germ line cyst formation	GO:0030727	42	0.939
eye morphogenesis	GO:0048592	260	0.935
female germ line cyst formation	GO:0048135	42	0.932
germarium derived oocyte fate determination	GO:0007294	26	0.928
organelle localization	GO:0051640	148	0.919
nucleus organization	GO:0006997	45	0.901
nuclear division	GO:0000280	332	0.895
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.891
oocyte fate determination	GO:0030716	27	0.884
oocyte construction	GO:0007308	112	0.882
organelle assembly	GO:0070925	198	0.877
defense response	GO:0006952	300	0.877
rna localization	GO:0006403	115	0.874
centrosome cycle	GO:0007098	137	0.860
intracellular transport	GO:0046907	228	0.843
ribonucleoside metabolic process	GO:0009119	127	0.833
lipid localization	GO:0010876	54	0.831
axis specification	GO:0009798	167	0.819
oocyte anterior posterior axis specification	GO:0007314	72	0.803
germ line cyst formation	GO:0048134	44	0.800
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.792
compound eye morphogenesis	GO:0001745	249	0.784
actin cytoskeleton organization	GO:0030036	206	0.784	Worm
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.762
eye development	GO:0001654	323	0.730
purine nucleotide catabolic process	GO:0006195	109	0.723
respiratory system development	GO:0060541	213	0.722
establishment of vesicle localization	GO:0051650	51	0.718
immune effector process	GO:0002252	98	0.705
endocytosis	GO:0006897	310	0.704
neuron projection guidance	GO:0097485	241	0.704
synaptic transmission	GO:0007268	288	0.702
regulation of response to stress	GO:0080134	200	0.699
response to biotic stimulus	GO:0009607	294	0.678
oocyte axis specification	GO:0007309	108	0.666
spindle localization	GO:0051653	22	0.666
organelle fission	GO:0048285	340	0.664
compound eye development	GO:0048749	307	0.660
purine nucleoside catabolic process	GO:0006152	112	0.644
response to abiotic stimulus	GO:0009628	341	0.643
positive regulation of response to stimulus	GO:0048584	323	0.630
biological adhesion	GO:0022610	138	0.616
meiotic cell cycle process	GO:1903046	132	0.615
male meiosis cytokinesis	GO:0007112	26	0.614
axonogenesis	GO:0007409	290	0.613
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.607
regulation of multi organism process	GO:0043900	131	0.599
vesicle localization	GO:0051648	55	0.598
meiotic cytokinesis	GO:0033206	33	0.594
germarium derived oocyte differentiation	GO:0030706	29	0.590
tissue morphogenesis	GO:0048729	297	0.569
segmentation	GO:0035282	207	0.557
single organism intracellular transport	GO:1902582	207	0.543
cytoplasmic transport	GO:0016482	130	0.539
open tracheal system development	GO:0007424	204	0.534
cell adhesion	GO:0007155	136	0.509
ribonucleoside catabolic process	GO:0042454	112	0.505
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.500
regulation of anatomical structure size	GO:0090066	163	0.496
posttranscriptional regulation of gene expression	GO:0010608	145	0.488
regulation of localization	GO:0032879	275	0.473
maintenance of protein location	GO:0045185	28	0.467
establishment of mitotic spindle orientation	GO:0000132	13	0.460
regulation of cell differentiation	GO:0045595	302	0.460
tube development	GO:0035295	244	0.452
glycosyl compound metabolic process	GO:1901657	127	0.443
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.423
establishment of synaptic vesicle localization	GO:0097480	50	0.422
inorganic ion transmembrane transport	GO:0098660	73	0.413
regulation of mitotic cell cycle	GO:0007346	190	0.412
exocytosis	GO:0006887	28	0.409
early endosome to late endosome transport	GO:0045022	3	0.408
regulation of cell cycle phase transition	GO:1901987	130	0.407
meiotic cell cycle	GO:0051321	171	0.404
regulation of actin polymerization or depolymerization	GO:0008064	27	0.404
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.403
striated muscle cell differentiation	GO:0051146	90	0.403
pole plasm assembly	GO:0007315	61	0.394
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.389
cell maturation	GO:0048469	144	0.382
nucleobase containing compound catabolic process	GO:0034655	165	0.380
chemotaxis	GO:0006935	249	0.377
synaptic vesicle transport	GO:0048489	50	0.366
maintenance of location	GO:0051235	73	0.365
meiotic nuclear division	GO:0007126	151	0.359
intracellular signal transduction	GO:0035556	300	0.358
purine nucleoside metabolic process	GO:0042278	127	0.351
regulation of tube diameter open tracheal system	GO:0035158	11	0.349
cell cell junction organization	GO:0045216	55	0.339
nucleoside catabolic process	GO:0009164	112	0.336
maintenance of protein location in cell	GO:0032507	26	0.326
regulation of cell cycle process	GO:0010564	181	0.323
cytokinesis	GO:0000910	90	0.319
negative regulation of cell cycle process	GO:0010948	109	0.318
establishment or maintenance of cell polarity	GO:0007163	167	0.316
cell division	GO:0051301	248	0.316
regulation of cytoskeleton organization	GO:0051493	89	0.311
single organism cellular localization	GO:1902580	180	0.309
endomembrane system organization	GO:0010256	119	0.305
translation	GO:0006412	69	0.299
immune system process	GO:0002376	347	0.299
intracellular mrna localization	GO:0008298	66	0.298
aromatic compound catabolic process	GO:0019439	166	0.293
maintenance of location in cell	GO:0051651	28	0.292
centrosome duplication	GO:0051298	121	0.287
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.281
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.280
nucleus localization	GO:0051647	34	0.277
establishment of spindle localization	GO:0051293	22	0.276
male gamete generation	GO:0048232	201	0.266
membrane organization	GO:0061024	112	0.262
nucleoside triphosphate catabolic process	GO:0009143	108	0.262
regulation of protein complex assembly	GO:0043254	42	0.260
negative regulation of mitotic cell cycle	GO:0045930	109	0.251
establishment of localization in cell	GO:0051649	402	0.246
response to other organism	GO:0051707	293	0.235
pole plasm rna localization	GO:0007316	52	0.234
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.232
regulation of cell maturation	GO:1903429	27	0.228
tube morphogenesis	GO:0035239	191	0.226
regulation of intracellular transport	GO:0032386	64	0.226
regulation of cellular localization	GO:0060341	136	0.225
establishment of rna localization	GO:0051236	47	0.214
vesicle organization	GO:0016050	44	0.213
cell motility	GO:0048870	251	0.213
cytoplasm organization	GO:0007028	64	0.212
developmental cell growth	GO:0048588	52	0.196
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.193
mitotic nuclear division	GO:0007067	213	0.192
regulation of immune system process	GO:0002682	176	0.192
response to external biotic stimulus	GO:0043207	293	0.190
mitotic cell cycle phase transition	GO:0044772	138	0.189
metal ion transport	GO:0030001	74	0.187
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.186
axon guidance	GO:0007411	233	0.185
actin cytoskeleton reorganization	GO:0031532	22	0.181
endosomal transport	GO:0016197	44	0.177
cytoskeleton dependent cytokinesis	GO:0061640	81	0.175
membrane tubulation	GO:0097320	4	0.170
organonitrogen compound metabolic process	GO:1901564	318	0.169
regulation of multicellular organismal development	GO:2000026	414	0.168
organonitrogen compound catabolic process	GO:1901565	128	0.167
nucleotide catabolic process	GO:0009166	109	0.159
regulation of actin filament length	GO:0030832	27	0.158
regulation of translation	GO:0006417	56	0.155
neurotransmitter secretion	GO:0007269	35	0.154
regulation of actin filament polymerization	GO:0030833	25	0.153
axon development	GO:0061564	297	0.152
cellular response to dna damage stimulus	GO:0006974	223	0.151
cell cycle phase transition	GO:0044770	140	0.150
cellular protein complex assembly	GO:0043623	71	0.148
aging	GO:0007568	143	0.147	Worm
defense response to bacterium	GO:0042742	178	0.147
regulation of immune response	GO:0050776	118	0.147
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.146
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.145
neurological system process	GO:0050877	358	0.145
actin filament based process	GO:0030029	220	0.145	Worm
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.144
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.142
regulation of cell development	GO:0060284	215	0.141
regulation of protein polymerization	GO:0032271	28	0.140
anterior posterior pattern specification	GO:0009952	136	0.139
nuclear migration	GO:0007097	20	0.139
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.136
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.135
developmental maturation	GO:0021700	172	0.132
purine ribonucleoside catabolic process	GO:0046130	112	0.131
cellular protein localization	GO:0034613	160	0.131
response to bacterium	GO:0009617	198	0.131
cellular component disassembly	GO:0022411	46	0.130
innate immune response	GO:0045087	144	0.129
positive regulation of actin filament polymerization	GO:0030838	11	0.129
response to heat	GO:0009408	63	0.128
regulation of response to biotic stimulus	GO:0002831	63	0.128
actin filament organization	GO:0007015	126	0.123
embryo development ending in birth or egg hatching	GO:0009792	152	0.119	Worm
regionalization	GO:0003002	416	0.117
phagocytosis	GO:0006909	215	0.115
growth	GO:0040007	359	0.115
spermatogenesis	GO:0007283	200	0.114
embryonic pattern specification	GO:0009880	174	0.112
response to wounding	GO:0009611	94	0.111
establishment of spindle orientation	GO:0051294	18	0.110
transmembrane transport	GO:0055085	139	0.109
chromosome segregation	GO:0007059	157	0.108
nucleoside monophosphate metabolic process	GO:0009123	52	0.108
organic substance catabolic process	GO:1901575	308	0.108	Worm
regulation of oocyte development	GO:0060281	27	0.108
cell growth	GO:0016049	108	0.107
nucleobase containing small molecule metabolic process	GO:0055086	174	0.107
ribonucleotide catabolic process	GO:0009261	109	0.106
eye photoreceptor cell differentiation	GO:0001754	145	0.103
nucleoside metabolic process	GO:0009116	127	0.102
pseudocleavage involved in syncytial blastoderm formation	GO:0030589	9	0.102
establishment of mitotic spindle localization	GO:0040001	17	0.099
receptor mediated endocytosis	GO:0006898	21	0.099	Worm
blastoderm segmentation	GO:0007350	159	0.099
cell proliferation	GO:0008283	299	0.099
ion transmembrane transport	GO:0034220	122	0.098
cellular protein complex disassembly	GO:0043624	35	0.098
positive regulation of developmental process	GO:0051094	143	0.097
positive regulation of nervous system development	GO:0051962	69	0.095
protein complex disassembly	GO:0043241	36	0.095
negative regulation of cell cycle phase transition	GO:1901988	103	0.094
digestive tract morphogenesis	GO:0048546	127	0.094
positive regulation of response to wounding	GO:1903036	15	0.093
regulation of defense response	GO:0031347	102	0.092
regulation of transport	GO:0051049	181	0.092
nucleoside phosphate catabolic process	GO:1901292	110	0.090
nuclear transport	GO:0051169	72	0.090
regulation of cell death	GO:0010941	173	0.089
cellular nitrogen compound catabolic process	GO:0044270	165	0.089
larval development	GO:0002164	104	0.088	Worm
epithelial cell development	GO:0002064	274	0.088
anatomical structure homeostasis	GO:0060249	97	0.087
atp metabolic process	GO:0046034	49	0.087
negative regulation of cellular metabolic process	GO:0031324	382	0.087
nucleoside monophosphate catabolic process	GO:0009125	39	0.086
nuclear import	GO:0051170	51	0.085
purine ribonucleotide catabolic process	GO:0009154	109	0.085
centrosome organization	GO:0051297	163	0.085
regulation of innate immune response	GO:0045088	71	0.085
macromolecular complex assembly	GO:0065003	256	0.084
imaginal disc growth	GO:0007446	37	0.083
pole plasm mrna localization	GO:0019094	49	0.080
heterocycle catabolic process	GO:0046700	166	0.080
actin filament polymerization	GO:0030041	27	0.080
immune response	GO:0006955	246	0.080
death	GO:0016265	284	0.077
dendrite development	GO:0016358	204	0.077
purine ribonucleoside metabolic process	GO:0046128	127	0.077
positive regulation of multicellular organismal process	GO:0051240	143	0.077
lipid storage	GO:0019915	38	0.075
cation transport	GO:0006812	110	0.075
negative regulation of gene expression	GO:0010629	387	0.074
digestive system development	GO:0055123	149	0.073
organic substance transport	GO:0071702	257	0.073
ion transport	GO:0006811	145	0.071
cellular macromolecule localization	GO:0070727	220	0.071
pole plasm oskar mrna localization	GO:0045451	46	0.069
columnar cuboidal epithelial cell development	GO:0002066	249	0.068
positive regulation of cell migration	GO:0030335	2	0.068
anterior posterior axis specification embryo	GO:0008595	103	0.068
cell cell junction assembly	GO:0007043	38	0.067
carbohydrate derivative metabolic process	GO:1901135	217	0.067
mitotic cell cycle checkpoint	GO:0007093	88	0.067
organic cyclic compound catabolic process	GO:1901361	168	0.067
meiotic chromosome segregation	GO:0045132	59	0.066
actomyosin structure organization	GO:0031032	56	0.066
glycosyl compound catabolic process	GO:1901658	112	0.066
regulation of cellular response to stress	GO:0080135	89	0.065
nucleocytoplasmic transport	GO:0006913	72	0.065
establishment of mitochondrion localization microtubule mediated	GO:0034643	6	0.064
purine nucleotide metabolic process	GO:0006163	146	0.064
heart development	GO:0007507	82	0.064
single organism membrane organization	GO:0044802	93	0.064
regulation of actin cytoskeleton organization	GO:0032956	42	0.064
regulation of cell growth	GO:0001558	43	0.063
regulation of cell motility	GO:2000145	23	0.063
membrane budding	GO:0006900	4	0.063
muscle cell differentiation	GO:0042692	103	0.062
purine ribonucleotide metabolic process	GO:0009150	145	0.062
positive regulation of cell development	GO:0010720	61	0.062
establishment of nucleus localization	GO:0040023	26	0.062
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.060
neuron projection extension	GO:1990138	32	0.060
protein complex assembly	GO:0006461	200	0.060
regulation of synapse structural plasticity	GO:0051823	3	0.058
regulation of protein metabolic process	GO:0051246	256	0.057
actin polymerization or depolymerization	GO:0008154	31	0.057
multi organism behavior	GO:0051705	175	0.057
acid secretion	GO:0046717	1	0.057
purine containing compound catabolic process	GO:0072523	112	0.056
regulation of cell cycle	GO:0051726	291	0.056
regulation of response to external stimulus	GO:0032101	115	0.056
regulation of vesicle mediated transport	GO:0060627	59	0.056
response to virus	GO:0009615	28	0.056
positive regulation of signal transduction	GO:0009967	223	0.056
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.055
regulation of locomotion	GO:0040012	42	0.054
regulation of microtubule based process	GO:0032886	49	0.054
protein targeting to nucleus	GO:0044744	51	0.053
single organism membrane fusion	GO:0044801	42	0.053
regulation of protein complex disassembly	GO:0043244	29	0.053
organophosphate catabolic process	GO:0046434	112	0.053
positive regulation of transport	GO:0051050	92	0.053
cytoskeleton dependent intracellular transport	GO:0030705	44	0.051
localization of cell	GO:0051674	257	0.051
nucleotide metabolic process	GO:0009117	161	0.051
regulation of tube architecture open tracheal system	GO:0035152	68	0.051
programmed cell death	GO:0012501	257	0.050
regulation of cellular component biogenesis	GO:0044087	201	0.049
negative regulation of cell differentiation	GO:0045596	143	0.049
striated muscle myosin thick filament assembly	GO:0071688	3	0.048
single organism nuclear import	GO:1902593	51	0.048
proteolysis	GO:0006508	192	0.048
appendage morphogenesis	GO:0035107	397	0.047
mrna transport	GO:0051028	15	0.047
microtubule based movement	GO:0007018	51	0.046
retrograde axon cargo transport	GO:0008090	9	0.045
establishment of cell polarity	GO:0030010	40	0.045
regulation of tube length open tracheal system	GO:0035159	24	0.045
regulation of cell proliferation	GO:0042127	163	0.044
secretion	GO:0046903	109	0.044
chromosome localization	GO:0050000	20	0.044
positive regulation of phosphate metabolic process	GO:0045937	139	0.043
cellular homeostasis	GO:0019725	80	0.043
positive regulation of cell communication	GO:0010647	250	0.043
macromolecular complex disassembly	GO:0032984	37	0.042
dorsal closure amnioserosa morphology change	GO:0046664	7	0.042
protein targeting	GO:0006605	64	0.042
positive regulation of defense response	GO:0031349	59	0.042
neuroblast division	GO:0055057	35	0.042
defense response to other organism	GO:0098542	225	0.041
axon extension	GO:0048675	32	0.041
rna transport	GO:0050658	46	0.040
phosphorylation	GO:0016310	294	0.040
positive regulation of cell motility	GO:2000147	3	0.040
regulation of tube size open tracheal system	GO:0035151	43	0.040
protein polymerization	GO:0051258	42	0.039
filopodium assembly	GO:0046847	33	0.039
protein localization to organelle	GO:0033365	82	0.039
protein localization to nucleus	GO:0034504	55	0.039
intracellular protein transport	GO:0006886	104	0.039
regulation of anatomical structure morphogenesis	GO:0022603	242	0.039
cell junction assembly	GO:0034329	42	0.039
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.039
sensory organ morphogenesis	GO:0090596	260	0.039
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.039
protein import	GO:0017038	55	0.038
synaptic vesicle recycling	GO:0036465	28	0.038
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.038
wing disc morphogenesis	GO:0007472	344	0.038
molting cycle	GO:0042303	56	0.038
organelle fusion	GO:0048284	46	0.037
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.036
neuron recognition	GO:0008038	101	0.035
body morphogenesis	GO:0010171	2	0.035
response to hormone	GO:0009725	45	0.035
compound eye photoreceptor cell differentiation	GO:0001751	140	0.035
protein localization	GO:0008104	284	0.035	Worm
positive regulation of translation	GO:0045727	12	0.034
regulation of system process	GO:0044057	36	0.034
dna metabolic process	GO:0006259	227	0.034
pronuclear migration	GO:0035046	4	0.034
golgi localization	GO:0051645	2	0.034
gliogenesis	GO:0042063	80	0.034
cell substrate adhesion	GO:0031589	10	0.033
taxis	GO:0042330	304	0.032
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.032
embryonic morphogenesis	GO:0048598	206	0.032
semaphorin plexin signaling pathway	GO:0071526	4	0.032
embryonic axis specification	GO:0000578	107	0.031
establishment of mitochondrion localization	GO:0051654	7	0.031
positive regulation of neurogenesis	GO:0050769	41	0.031
regulation of cytoplasmic transport	GO:1903649	47	0.031
regulation of molecular function	GO:0065009	217	0.031
lamellipodium assembly	GO:0030032	21	0.031
protein import into nucleus	GO:0006606	51	0.031
synapse assembly	GO:0007416	143	0.031
adherens junction organization	GO:0034332	27	0.031
determination of adult lifespan	GO:0008340	137	0.031	Worm
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.031
autophagy	GO:0006914	108	0.031
developmental programmed cell death	GO:0010623	138	0.031
protein transport	GO:0015031	155	0.031
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.030
negative regulation of multi organism process	GO:0043901	29	0.030
regulation of cell division	GO:0051302	72	0.030
positive regulation of apoptotic process	GO:0043065	47	0.030
positive regulation of cell death	GO:0010942	69	0.030
positive regulation of response to external stimulus	GO:0032103	44	0.030
response to nutrient levels	GO:0031667	114	0.029	Worm
lateral inhibition	GO:0046331	206	0.029
regulation of protein localization to nucleus	GO:1900180	29	0.029
microtubule anchoring	GO:0034453	11	0.029
regulation of receptor mediated endocytosis	GO:0048259	9	0.028
response to extracellular stimulus	GO:0009991	116	0.028	Worm
regulation of cell substrate adhesion	GO:0010810	2	0.028
mitotic spindle organization	GO:0007052	220	0.028
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.028
response to starvation	GO:0042594	97	0.028	Worm
response to temperature stimulus	GO:0009266	106	0.028
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.027
morphogenesis of an epithelium	GO:0002009	276	0.027
positive regulation of intracellular transport	GO:0032388	42	0.027
digestive tract development	GO:0048565	149	0.027
small molecule metabolic process	GO:0044281	305	0.027
tripartite regional subdivision	GO:0007351	103	0.027
necrotic cell death	GO:0070265	1	0.027
positive regulation of exocytosis	GO:0045921	4	0.027
morphogenesis of a branching epithelium	GO:0061138	45	0.026
plasma membrane organization	GO:0007009	26	0.026
oviposition	GO:0018991	19	0.026
pigment cell differentiation	GO:0050931	3	0.026
photoreceptor cell differentiation	GO:0046530	170	0.025
compound eye photoreceptor development	GO:0042051	78	0.025
epithelial cell cell adhesion	GO:0090136	6	0.025
regulation of cellular component movement	GO:0051270	42	0.025
regulation of nervous system development	GO:0051960	248	0.025
positive energy taxis	GO:0052128	3	0.025
centriole assembly	GO:0098534	24	0.025
positive regulation of macromolecule metabolic process	GO:0010604	405	0.025
wound healing	GO:0042060	75	0.024
pole plasm protein localization	GO:0007318	10	0.024
dna repair	GO:0006281	54	0.024
positive regulation of secretion	GO:0051047	22	0.024
spindle organization	GO:0007051	253	0.023
positive regulation of axonogenesis	GO:0050772	2	0.023
developmental growth	GO:0048589	280	0.023
trna modification	GO:0006400	2	0.023
response to organic cyclic compound	GO:0014070	89	0.023
epithelial tube morphogenesis	GO:0060562	88	0.023
photoreceptor cell development	GO:0042461	96	0.022
reproductive structure development	GO:0048608	74	0.022
carbohydrate derivative catabolic process	GO:1901136	118	0.022
response to endogenous stimulus	GO:0009719	119	0.022
cellular pigmentation	GO:0033059	12	0.022
synaptic vesicle endocytosis	GO:0048488	28	0.022
ovarian fusome organization	GO:0030723	11	0.022
cell migration	GO:0016477	238	0.022
positive regulation of axon extension	GO:0045773	2	0.022
protein depolymerization	GO:0051261	31	0.022
protein localization to plasma membrane	GO:0072659	13	0.022
positive regulation of protein localization to nucleus	GO:1900182	21	0.022
multicellular organismal aging	GO:0010259	140	0.021	Worm
atp catabolic process	GO:0006200	38	0.021
organophosphate metabolic process	GO:0019637	195	0.021
cell cycle checkpoint	GO:0000075	95	0.021
cellular response to chemical stimulus	GO:0070887	199	0.021
regulation of nuclear division	GO:0051783	58	0.021
mitotic cytokinesis	GO:0000281	50	0.021
establishment of protein localization to plasma membrane	GO:0090002	9	0.021
eye photoreceptor cell development	GO:0042462	81	0.021
appendage development	GO:0048736	401	0.021
establishment of protein localization to organelle	GO:0072594	62	0.021
notch signaling pathway	GO:0007219	120	0.020
positive regulation of histone modification	GO:0031058	12	0.020
single organism behavior	GO:0044708	391	0.020
regulation of epithelial cell migration open tracheal system	GO:2000274	11	0.020
cation transmembrane transport	GO:0098655	88	0.020
cell junction organization	GO:0034330	57	0.020
myosin filament organization	GO:0031033	5	0.020
positive regulation of fibroblast growth factor receptor signaling pathway	GO:0045743	5	0.020
apical junction assembly	GO:0043297	32	0.020
dendrite morphogenesis	GO:0048813	199	0.020
positive regulation of chromatin modification	GO:1903310	17	0.020
response to light stimulus	GO:0009416	124	0.020
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	24	0.019
regulation of dna templated transcription elongation	GO:0032784	17	0.019
dorsal ventral axis specification	GO:0009950	66	0.019
ubiquitin dependent protein catabolic process	GO:0006511	78	0.019
gastrulation	GO:0007369	70	0.019
dorsal appendage formation	GO:0046843	47	0.019
neuroblast proliferation	GO:0007405	74	0.019
regulation of cell size	GO:0008361	63	0.019
regulation of nucleocytoplasmic transport	GO:0046822	35	0.019
regeneration	GO:0031099	16	0.019
protein phosphorylation	GO:0006468	169	0.019
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.019
epithelial cell differentiation	GO:0030855	322	0.018
cardiovascular system development	GO:0072358	82	0.018
microtubule organizing center organization	GO:0031023	168	0.018
positive regulation of cytoskeleton organization	GO:0051495	21	0.018
negative regulation of organelle organization	GO:0010639	56	0.018
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.018
positive regulation of cellular component organization	GO:0051130	156	0.018
cellular response to hexose stimulus	GO:0071331	1	0.017
synaptic vesicle localization	GO:0097479	53	0.017
regulation of protein import into nucleus	GO:0042306	28	0.017
regulation of phosphate metabolic process	GO:0019220	210	0.017
centriole replication	GO:0007099	24	0.017
single organism cell adhesion	GO:0098602	47	0.017
telencephalon development	GO:0021537	2	0.017
cell death	GO:0008219	279	0.017
apoptotic signaling pathway	GO:0097190	27	0.017
nucleoside triphosphate metabolic process	GO:0009141	120	0.017
chromosome separation	GO:0051304	42	0.016
actomyosin contractile ring assembly	GO:0000915	10	0.016
negative regulation of signal transduction by p53 class mediator	GO:1901797	1	0.016
protein complex biogenesis	GO:0070271	201	0.016
divalent metal ion transport	GO:0070838	26	0.016

Chc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.254
nervous system disease	DOID:863	0.050
cardiovascular system disease	DOID:1287	0.036
muscular disease	DOID:0080000	0.035
muscle tissue disease	DOID:66	0.035
musculoskeletal system disease	DOID:17	0.035
neuropathy	DOID:870	0.027

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