IMP: Integrative Multi-species Prediction

Drosophila melanogaster

24 known processes

Gpdh (Dmel_CG9042)

Glycerol 3 phosphate dehydrogenase

(Aliases: gpdh,Dmel\CG9042,GPDA,sn-Gpdh,DmG3PDH,alpha-GPD,GPD,alphaGpdh,alpha-GPDH,G3PDH,alphaGpdh-1,DROGPDHA,GAPDH,Gpd,alphaGpd,Gdh,CG9042,alpha-GPDH-1,GPDH,alphaGPDH,alpha-Gpdh)

FLYBASE: FBgn0001128
Entrez: 33824
UniProtKB: M9PET0
UniProtKB: M9PC43
UniProtKB: P13706
UniProtKB: B5RIM9

Process Predictions
Disease Predictions

Gpdh biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
adult behavior	GO:0030534	137	0.979
carbohydrate biosynthetic process	GO:0016051	17	0.549	Mouse
energy derivation by oxidation of organic compounds	GO:0015980	32	0.527	Mouse
nad metabolic process	GO:0019674	1	0.448
oxidation reduction process	GO:0055114	123	0.374	Mouse
determination of adult lifespan	GO:0008340	137	0.341
single organism behavior	GO:0044708	391	0.312
striated muscle cell development	GO:0055002	50	0.284
somatic muscle development	GO:0007525	66	0.280
carbohydrate metabolic process	GO:0005975	82	0.274	Mouse
cellular component assembly involved in morphogenesis	GO:0010927	151	0.247
sarcomere organization	GO:0045214	26	0.243
single organism biosynthetic process	GO:0044711	206	0.240	Mouse
organophosphate metabolic process	GO:0019637	195	0.234	Mouse
nucleobase containing small molecule metabolic process	GO:0055086	174	0.201
muscle system process	GO:0003012	21	0.189
striated muscle myosin thick filament assembly	GO:0071688	3	0.183
multicellular organismal aging	GO:0010259	140	0.167
organic substance catabolic process	GO:1901575	308	0.163	Mouse
single organism carbohydrate metabolic process	GO:0044723	72	0.156	Mouse
cellular lipid catabolic process	GO:0044242	16	0.151
endocytosis	GO:0006897	310	0.146
purine containing compound metabolic process	GO:0072521	155	0.136
actin cytoskeleton organization	GO:0030036	206	0.131
aging	GO:0007568	143	0.130
melanin metabolic process	GO:0006582	47	0.129
developmental growth	GO:0048589	280	0.127
cell death	GO:0008219	279	0.126
acetaldehyde metabolic process	GO:0006117	5	0.118
organic substance transport	GO:0071702	257	0.116
myofibril assembly	GO:0030239	36	0.116
regulation of growth	GO:0040008	233	0.114
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.114
lipid localization	GO:0010876	54	0.111
glycerolipid catabolic process	GO:0046503	3	0.110
camera type eye development	GO:0043010	4	0.106
organic acid metabolic process	GO:0006082	103	0.101	Mouse
organonitrogen compound metabolic process	GO:1901564	318	0.098
regulation of cell cycle	GO:0051726	291	0.096
protein complex biogenesis	GO:0070271	201	0.095
lipid metabolic process	GO:0006629	121	0.091
purine nucleoside metabolic process	GO:0042278	127	0.086
nitrogen compound transport	GO:0071705	85	0.085
single organism catabolic process	GO:0044712	228	0.079	Mouse
catabolic process	GO:0009056	409	0.076	Mouse
regulation of tube size open tracheal system	GO:0035151	43	0.075
purine nucleoside biosynthetic process	GO:0042451	3	0.074
protein complex assembly	GO:0006461	200	0.073
cellular lipid metabolic process	GO:0044255	83	0.073
cellular response to transforming growth factor beta stimulus	GO:0071560	18	0.072
oxoacid metabolic process	GO:0043436	103	0.071	Mouse
growth	GO:0040007	359	0.070
wound healing	GO:0042060	75	0.064
actin filament based process	GO:0030029	220	0.062
cellular polysaccharide metabolic process	GO:0044264	11	0.062
flight behavior	GO:0007629	26	0.061
glycosyl compound metabolic process	GO:1901657	127	0.060
response to transforming growth factor beta	GO:0071559	18	0.059
epithelial cell differentiation	GO:0030855	322	0.059
carbohydrate derivative metabolic process	GO:1901135	217	0.059	Mouse
generation of precursor metabolites and energy	GO:0006091	42	0.055	Mouse
small molecule metabolic process	GO:0044281	305	0.054	Mouse
localization of cell	GO:0051674	257	0.052
glycerol 3 phosphate metabolic process	GO:0006072	2	0.052	Mouse
striated muscle contraction	GO:0006941	5	0.051
cellular nitrogen compound catabolic process	GO:0044270	165	0.050
regulation of multicellular organismal development	GO:2000026	414	0.050
organic hydroxy compound metabolic process	GO:1901615	83	0.050
cellular amino acid metabolic process	GO:0006520	61	0.049
ovarian follicle cell development	GO:0030707	248	0.049
striated muscle cell differentiation	GO:0051146	90	0.048
pyridine containing compound metabolic process	GO:0072524	3	0.048
adult locomotory behavior	GO:0008344	76	0.048
positive regulation of catabolic process	GO:0009896	105	0.048	Mouse
purine ribonucleoside metabolic process	GO:0046128	127	0.047
regulation of cell death	GO:0010941	173	0.046
gonad development	GO:0008406	50	0.045
phagocytosis	GO:0006909	215	0.045
acylglycerol biosynthetic process	GO:0046463	2	0.045
positive regulation of transport	GO:0051050	92	0.044
glucose metabolic process	GO:0006006	5	0.044	Mouse
ribonucleoside metabolic process	GO:0009119	127	0.042
negative regulation of cell cycle	GO:0045786	116	0.042
primary alcohol metabolic process	GO:0034308	2	0.041
lipid storage	GO:0019915	38	0.041
telencephalon development	GO:0021537	2	0.041
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.040
neutral lipid catabolic process	GO:0046461	3	0.039
regulation of purine nucleotide metabolic process	GO:1900542	62	0.039
cellular catabolic process	GO:0044248	372	0.039	Mouse
ribose phosphate metabolic process	GO:0019693	145	0.039
epidermis development	GO:0008544	65	0.038
negative regulation of biosynthetic process	GO:0009890	277	0.037
regulation of cell differentiation	GO:0045595	302	0.037
response to hexose	GO:0009746	3	0.037
nucleotide biosynthetic process	GO:0009165	34	0.036
imaginal disc derived appendage development	GO:0048737	399	0.036
positive regulation of cellular biosynthetic process	GO:0031328	316	0.035
monosaccharide metabolic process	GO:0005996	9	0.034	Mouse
response to monosaccharide	GO:0034284	4	0.034
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.034
behavioral response to ethanol	GO:0048149	49	0.034
cellular macromolecular complex assembly	GO:0034622	153	0.034
vesicle mediated transport	GO:0016192	381	0.034
heterocycle catabolic process	GO:0046700	166	0.034
columnar cuboidal epithelial cell development	GO:0002066	249	0.034
nucleocytoplasmic transport	GO:0006913	72	0.034
skeletal muscle myosin thick filament assembly	GO:0030241	3	0.034
electron transport chain	GO:0022900	14	0.033	Mouse
cell migration	GO:0016477	238	0.033
hexose metabolic process	GO:0019318	8	0.033	Mouse
myosin filament assembly	GO:0031034	5	0.033
brain development	GO:0007420	120	0.033
positive regulation of catalytic activity	GO:0043085	118	0.032
nucleoside triphosphate metabolic process	GO:0009141	120	0.031
wing disc morphogenesis	GO:0007472	344	0.031
nucleoside phosphate metabolic process	GO:0006753	162	0.030
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.030
homeostatic process	GO:0042592	199	0.030
actomyosin structure organization	GO:0031032	56	0.030
multi organism behavior	GO:0051705	175	0.029
nucleoside metabolic process	GO:0009116	127	0.029
protein localization	GO:0008104	284	0.029
defense response	GO:0006952	300	0.028
body morphogenesis	GO:0010171	2	0.028
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.028
polysaccharide metabolic process	GO:0005976	11	0.026
regulation of cellular catabolic process	GO:0031329	157	0.026	Mouse
fatty acid metabolic process	GO:0006631	20	0.026
muscle tissue morphogenesis	GO:0060415	2	0.026
negative regulation of cellular biosynthetic process	GO:0031327	277	0.026
ribonucleoside biosynthetic process	GO:0042455	3	0.025
pyruvate metabolic process	GO:0006090	7	0.025	Mouse
regulation of apoptotic process	GO:0042981	130	0.024
skin development	GO:0043588	65	0.024
muscle cell development	GO:0055001	50	0.024
cellular respiration	GO:0045333	26	0.023	Mouse
skeletal muscle fiber development	GO:0048741	3	0.023
carbohydrate derivative catabolic process	GO:1901136	118	0.023
response to wounding	GO:0009611	94	0.023
regulation of catalytic activity	GO:0050790	185	0.023
muscle contraction	GO:0006936	13	0.022
larval development	GO:0002164	104	0.022
response to organonitrogen compound	GO:0010243	75	0.022	Mouse
embryo development ending in birth or egg hatching	GO:0009792	152	0.022
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.022
regulation of phosphate metabolic process	GO:0019220	210	0.022
ribonucleoside catabolic process	GO:0042454	112	0.022
maintenance of location	GO:0051235	73	0.021
protein transport	GO:0015031	155	0.021
digestive tract morphogenesis	GO:0048546	127	0.021
organelle assembly	GO:0070925	198	0.021
monocarboxylic acid metabolic process	GO:0032787	29	0.021	Mouse
purine nucleotide metabolic process	GO:0006163	146	0.021
polysaccharide biosynthetic process	GO:0000271	7	0.020
monocarboxylic acid biosynthetic process	GO:0072330	7	0.020
neuromuscular synaptic transmission	GO:0007274	67	0.020
regionalization	GO:0003002	416	0.020
transmembrane transport	GO:0055085	139	0.020
purine ribonucleotide metabolic process	GO:0009150	145	0.020
cellular polysaccharide biosynthetic process	GO:0033692	7	0.020
carboxylic acid metabolic process	GO:0019752	92	0.020	Mouse
regulation of phosphorus metabolic process	GO:0051174	210	0.020
regulation of hydrolase activity	GO:0051336	97	0.019
transcription from rna polymerase ii promoter	GO:0006366	368	0.019
establishment of localization in cell	GO:0051649	402	0.019	Mouse
hair cell differentiation	GO:0035315	47	0.019
reproductive system development	GO:0061458	74	0.019
establishment of nucleus localization	GO:0040023	26	0.019
connective tissue development	GO:0061448	3	0.019
organonitrogen compound biosynthetic process	GO:1901566	117	0.019
cellular response to endogenous stimulus	GO:0071495	80	0.019	Mouse
innate immune response	GO:0045087	144	0.019
digestive system development	GO:0055123	149	0.019
intracellular transport	GO:0046907	228	0.018	Mouse
aromatic compound catabolic process	GO:0019439	166	0.018
regulation of response to stress	GO:0080134	200	0.018
positive regulation of cellular catabolic process	GO:0031331	95	0.018	Mouse
programmed cell death	GO:0012501	257	0.018
glycolytic process	GO:0006096	6	0.018	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.018
locomotory behavior	GO:0007626	176	0.018
lipid biosynthetic process	GO:0008610	46	0.017
regulation of catabolic process	GO:0009894	170	0.017	Mouse
cellular protein complex assembly	GO:0043623	71	0.017
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.017
glycosyl compound biosynthetic process	GO:1901659	3	0.017
regulation of developmental growth	GO:0048638	174	0.017
regulation of transport	GO:0051049	181	0.017
response to nitrogen compound	GO:1901698	90	0.017	Mouse
response to endogenous stimulus	GO:0009719	119	0.017	Mouse
eye development	GO:0001654	323	0.016
regulation of anatomical structure morphogenesis	GO:0022603	242	0.016
positive regulation of lipid metabolic process	GO:0045834	4	0.016
regulation of phosphorylation	GO:0042325	147	0.016
response to organic substance	GO:0010033	284	0.016	Mouse
tube morphogenesis	GO:0035239	191	0.016
regulation of steroid metabolic process	GO:0019218	2	0.016
epithelial cell development	GO:0002064	274	0.016
purine containing compound catabolic process	GO:0072523	112	0.016
alditol phosphate metabolic process	GO:0052646	2	0.015	Mouse
regulation of actin filament depolymerization	GO:0030834	3	0.015
nucleoside biosynthetic process	GO:0009163	3	0.015
positive regulation of molecular function	GO:0044093	136	0.015
muscle cell differentiation	GO:0042692	103	0.015
organonitrogen compound catabolic process	GO:1901565	128	0.015
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.015
cellular response to organic substance	GO:0071310	132	0.015	Mouse
monocarboxylic acid transport	GO:0015718	3	0.015
retina development in camera type eye	GO:0060041	4	0.015
regulation of nucleotide catabolic process	GO:0030811	48	0.014
triglyceride catabolic process	GO:0019433	3	0.014
purine ribonucleoside biosynthetic process	GO:0046129	3	0.014
flight	GO:0060361	10	0.014
alcohol metabolic process	GO:0006066	25	0.014
organic hydroxy compound catabolic process	GO:1901616	4	0.014
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.014
death	GO:0016265	284	0.014
immune system process	GO:0002376	347	0.014
purine ribonucleoside monophosphate biosynthetic process	GO:0009168	3	0.014
mitochondrion organization	GO:0007005	65	0.014
response to oxygen containing compound	GO:1901700	200	0.014	Mouse
cellular protein localization	GO:0034613	160	0.014
ameboidal type cell migration	GO:0001667	151	0.014
positive regulation of phosphate metabolic process	GO:0045937	139	0.014
epithelial cell migration	GO:0010631	148	0.014
cellular macromolecule localization	GO:0070727	220	0.014
regulation of dna templated transcription in response to stress	GO:0043620	4	0.014
positive regulation of macromolecule metabolic process	GO:0010604	405	0.014
cell motility	GO:0048870	251	0.013
lipid catabolic process	GO:0016042	21	0.013
posttranscriptional regulation of gene expression	GO:0010608	145	0.013
nicotinamide nucleotide metabolic process	GO:0046496	2	0.013
actin filament based movement	GO:0030048	26	0.013
multi organism reproductive behavior	GO:0044705	121	0.013
nucleotide catabolic process	GO:0009166	109	0.013
response to alcohol	GO:0097305	95	0.013
response to growth factor	GO:0070848	31	0.013
regulation of cellular amine metabolic process	GO:0033238	3	0.013
ovulation	GO:0030728	4	0.013
nadh metabolic process	GO:0006734	1	0.013
purine containing compound biosynthetic process	GO:0072522	30	0.013
regulation of cellular component biogenesis	GO:0044087	201	0.013
purine nucleoside catabolic process	GO:0006152	112	0.013
sperm mitochondrion organization	GO:0030382	7	0.012
morphogenesis of a branching epithelium	GO:0061138	45	0.012
cellular amine metabolic process	GO:0044106	12	0.012
negative regulation of actin filament depolymerization	GO:0030835	2	0.012
regulation of system process	GO:0044057	36	0.012
regulation of anatomical structure size	GO:0090066	163	0.012
cytoskeleton dependent intracellular transport	GO:0030705	44	0.012
positive regulation of hydrolase activity	GO:0051345	78	0.012
stem cell development	GO:0048864	79	0.012
response to abiotic stimulus	GO:0009628	341	0.012
macromolecular complex assembly	GO:0065003	256	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.011
regulation of protein transport	GO:0051223	57	0.011
negative regulation of developmental process	GO:0051093	201	0.011
response to lipopolysaccharide	GO:0032496	4	0.011
protein modification process	GO:0036211	438	0.011
sex differentiation	GO:0007548	81	0.011
regulation of establishment of protein localization	GO:0070201	61	0.011
regulation of cell motility	GO:2000145	23	0.011
negative regulation of catalytic activity	GO:0043086	42	0.011
notch signaling pathway	GO:0007219	120	0.011
positive regulation of nucleotide metabolic process	GO:0045981	55	0.011
nucleus organization	GO:0006997	45	0.011
ion transport	GO:0006811	145	0.011
lateral inhibition	GO:0046331	206	0.011
regulation of localization	GO:0032879	275	0.011
dna integrity checkpoint	GO:0031570	81	0.011
tissue migration	GO:0090130	155	0.011
purine ribonucleoside catabolic process	GO:0046130	112	0.011
synaptic transmission	GO:0007268	288	0.011
male mating behavior	GO:0060179	70	0.011
nucleoside triphosphate catabolic process	GO:0009143	108	0.011
carboxylic acid biosynthetic process	GO:0046394	15	0.011
regulation of programmed cell death	GO:0043067	152	0.010
purine nucleotide catabolic process	GO:0006195	109	0.010
compound eye development	GO:0048749	307	0.010
tricarboxylic acid metabolic process	GO:0072350	1	0.010
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.010
reproductive structure development	GO:0048608	74	0.010
positive regulation of multicellular organismal process	GO:0051240	143	0.010
epithelium migration	GO:0090132	148	0.010
positive regulation of phosphorus metabolic process	GO:0010562	139	0.010
nucleotide metabolic process	GO:0009117	161	0.010
organic anion transport	GO:0015711	28	0.010
mapk cascade	GO:0000165	107	0.010
neutral lipid metabolic process	GO:0006638	12	0.010
phenol containing compound metabolic process	GO:0018958	57	0.010
intracellular signal transduction	GO:0035556	300	0.010

Gpdh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.140
glucose metabolism disease	DOID:4194	0.140
acquired metabolic disease	DOID:0060158	0.140
carbohydrate metabolism disease	DOID:0050013	0.140
disease of anatomical entity	DOID:7	0.025
musculoskeletal system disease	DOID:17	0.015
cardiovascular system disease	DOID:1287	0.015
heart disease	DOID:114	0.015
myopathy	DOID:423	0.015
cardiomyopathy	DOID:0050700	0.015
dilated cardiomyopathy	DOID:12930	0.015
muscle tissue disease	DOID:66	0.015
muscular disease	DOID:0080000	0.015
intrinsic cardiomyopathy	DOID:0060036	0.015
primary hypertrophic osteoarthropathy	DOID:14283	0.014
syndrome	DOID:225	0.014
nervous system disease	DOID:863	0.012
central nervous system disease	DOID:331	0.012
inherited metabolic disorder	DOID:655	0.012
neurodegenerative disease	DOID:1289	0.010

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