IMP: Integrative Multi-species Prediction

Drosophila melanogaster

69 known processes

Aats-trp (Dmel_CG9735)

Tryptophanyl-tRNA synthetase

(Aliases: TrpRS,l(3)03560,l(3)03559,85D-WRS,Dmel\CG9735,WRS,wars,CG9735,WRS-85D,l(3)3559)

Entrez: 45399
FLYBASE: FBgn0010803
UniProtKB: Q0KI98

Process Predictions
Disease Predictions

Aats-trp biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
translation	GO:0006412	69	0.923
trna aminoacylation for protein translation	GO:0006418	2	0.631
axon development	GO:0061564	297	0.611
cellular macromolecule localization	GO:0070727	220	0.540
regionalization	GO:0003002	416	0.412
dendrite morphogenesis	GO:0048813	199	0.352
axonogenesis	GO:0007409	290	0.352
single organism cellular localization	GO:1902580	180	0.332
oocyte construction	GO:0007308	112	0.302
trna aminoacylation	GO:0043039	2	0.269
dendrite development	GO:0016358	204	0.214
oocyte axis specification	GO:0007309	108	0.206
oocyte development	GO:0048599	124	0.199
axon guidance	GO:0007411	233	0.189
axis specification	GO:0009798	167	0.189
positive regulation of macromolecule metabolic process	GO:0010604	405	0.186
central nervous system development	GO:0007417	201	0.174
ribose phosphate metabolic process	GO:0019693	145	0.168
blastoderm segmentation	GO:0007350	159	0.166
embryonic pattern specification	GO:0009880	174	0.150
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.147
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.142
cell death	GO:0008219	279	0.127
cell migration	GO:0016477	238	0.126
positive regulation of translation	GO:0045727	12	0.114
protein localization to organelle	GO:0033365	82	0.109
neuron projection guidance	GO:0097485	241	0.107
chemotaxis	GO:0006935	249	0.105
nucleotide catabolic process	GO:0009166	109	0.104
transcription from rna polymerase ii promoter	GO:0006366	368	0.102
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.093
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.090
organonitrogen compound metabolic process	GO:1901564	318	0.090
embryo development ending in birth or egg hatching	GO:0009792	152	0.089
purine ribonucleotide metabolic process	GO:0009150	145	0.089
anterior posterior axis specification embryo	GO:0008595	103	0.088
mitochondrion organization	GO:0007005	65	0.086
carbohydrate derivative catabolic process	GO:1901136	118	0.085
positive regulation of rna biosynthetic process	GO:1902680	266	0.079
pole plasm oskar mrna localization	GO:0045451	46	0.077
organophosphate metabolic process	GO:0019637	195	0.077
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.077
segmentation	GO:0035282	207	0.076
positive regulation of developmental growth	GO:0048639	62	0.076
negative regulation of autophagy	GO:0010507	16	0.073
developmental maturation	GO:0021700	172	0.071
ncrna metabolic process	GO:0034660	43	0.071
pole plasm rna localization	GO:0007316	52	0.069
pole plasm mrna localization	GO:0019094	49	0.068
nucleobase containing small molecule metabolic process	GO:0055086	174	0.067
aromatic compound catabolic process	GO:0019439	166	0.067
oocyte anterior posterior axis specification	GO:0007314	72	0.063
carbohydrate derivative metabolic process	GO:1901135	217	0.063
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.061
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.061
regulation of protein metabolic process	GO:0051246	256	0.060
cytoplasm organization	GO:0007028	64	0.060
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.060
death	GO:0016265	284	0.060
embryonic axis specification	GO:0000578	107	0.059
dorsal ventral pattern formation	GO:0009953	133	0.058
open tracheal system development	GO:0007424	204	0.057
columnar cuboidal epithelial cell development	GO:0002066	249	0.057
purine ribonucleoside metabolic process	GO:0046128	127	0.057
positive regulation of cellular biosynthetic process	GO:0031328	316	0.056
cell maturation	GO:0048469	144	0.056
ribonucleotide metabolic process	GO:0009259	145	0.054
tripartite regional subdivision	GO:0007351	103	0.053
positive regulation of gene expression	GO:0010628	290	0.051
pole plasm assembly	GO:0007315	61	0.050
regulation of developmental growth	GO:0048638	174	0.048
purine nucleotide metabolic process	GO:0006163	146	0.047
single organism catabolic process	GO:0044712	228	0.045
positive regulation of developmental process	GO:0051094	143	0.044
organic substance catabolic process	GO:1901575	308	0.044
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.043
autophagy	GO:0006914	108	0.042
rna localization	GO:0006403	115	0.042
organic acid metabolic process	GO:0006082	103	0.041
organic cyclic compound catabolic process	GO:1901361	168	0.040
head development	GO:0060322	135	0.039
anterior posterior axis specification	GO:0009948	109	0.038
ribonucleoside catabolic process	GO:0042454	112	0.037
heterocycle catabolic process	GO:0046700	166	0.036
trna metabolic process	GO:0006399	5	0.036
catabolic process	GO:0009056	409	0.036
protein transport	GO:0015031	155	0.036
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.036
nucleoside triphosphate catabolic process	GO:0009143	108	0.036
purine nucleotide catabolic process	GO:0006195	109	0.036
epithelial cell development	GO:0002064	274	0.035
amino acid activation	GO:0043038	3	0.034
programmed cell death	GO:0012501	257	0.034
tissue morphogenesis	GO:0048729	297	0.034
regulation of localization	GO:0032879	275	0.033
anterior posterior pattern specification	GO:0009952	136	0.032
regulation of anatomical structure morphogenesis	GO:0022603	242	0.032
intracellular mrna localization	GO:0008298	66	0.032
positive regulation of rna metabolic process	GO:0051254	271	0.031
forebrain development	GO:0030900	2	0.031
nucleoside catabolic process	GO:0009164	112	0.031
regulation of cell morphogenesis	GO:0022604	163	0.031
regulation of catabolic process	GO:0009894	170	0.030
negative regulation of cellular metabolic process	GO:0031324	382	0.030
cellular catabolic process	GO:0044248	372	0.030
endocytosis	GO:0006897	310	0.030
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.030
negative regulation of immune system process	GO:0002683	50	0.029
cellular protein localization	GO:0034613	160	0.029
ribonucleoside metabolic process	GO:0009119	127	0.029
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.029
protein targeting	GO:0006605	64	0.029
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.029
post embryonic appendage morphogenesis	GO:0035120	385	0.029
regulation of cell death	GO:0010941	173	0.029
positive regulation of transcription dna templated	GO:0045893	266	0.028
regulation of cellular protein metabolic process	GO:0032268	243	0.028
positive regulation of biosynthetic process	GO:0009891	316	0.028
establishment of localization in cell	GO:0051649	402	0.028
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.027
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.027
regulation of multicellular organismal development	GO:2000026	414	0.027
cytoplasmic transport	GO:0016482	130	0.027
localization of cell	GO:0051674	257	0.025
tube development	GO:0035295	244	0.025
eye photoreceptor cell differentiation	GO:0001754	145	0.025
purine nucleoside metabolic process	GO:0042278	127	0.025
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.025
developmental growth involved in morphogenesis	GO:0060560	65	0.025
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.025
nucleobase containing compound catabolic process	GO:0034655	165	0.024
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.024
intracellular protein transport	GO:0006886	104	0.024
glycosyl compound catabolic process	GO:1901658	112	0.024
respiratory system development	GO:0060541	213	0.024
negative regulation of biosynthetic process	GO:0009890	277	0.024
glycosyl compound metabolic process	GO:1901657	127	0.023
ovarian follicle cell migration	GO:0007297	121	0.023
nucleoside phosphate metabolic process	GO:0006753	162	0.023
determination of adult lifespan	GO:0008340	137	0.023
regulation of oocyte development	GO:0060281	27	0.023
male gamete generation	GO:0048232	201	0.022
chitin based cuticle development	GO:0040003	49	0.022
intracellular transport	GO:0046907	228	0.022
rna processing	GO:0006396	147	0.022
purine nucleoside catabolic process	GO:0006152	112	0.022
macromolecule catabolic process	GO:0009057	161	0.021
wing disc pattern formation	GO:0035222	66	0.021
tube morphogenesis	GO:0035239	191	0.020
photoreceptor cell differentiation	GO:0046530	170	0.020
regulation of immune system process	GO:0002682	176	0.020
small molecule metabolic process	GO:0044281	305	0.020
cell motility	GO:0048870	251	0.020
regulation of multi organism process	GO:0043900	131	0.020
protein localization	GO:0008104	284	0.020
purine containing compound metabolic process	GO:0072521	155	0.020
nucleoside triphosphate metabolic process	GO:0009141	120	0.019
oocyte dorsal ventral axis specification	GO:0007310	34	0.019
regulation of cellular catabolic process	GO:0031329	157	0.019
mitochondrial rna metabolic process	GO:0000959	5	0.019
negative regulation of cellular catabolic process	GO:0031330	34	0.019
morphogenesis of a branching epithelium	GO:0061138	45	0.019
establishment of protein localization to organelle	GO:0072594	62	0.019
compound eye development	GO:0048749	307	0.019
eye morphogenesis	GO:0048592	260	0.019
ovarian follicle cell development	GO:0030707	248	0.019
taxis	GO:0042330	304	0.018
organic substance transport	GO:0071702	257	0.018
regulation of cell maturation	GO:1903429	27	0.018
purine containing compound catabolic process	GO:0072523	112	0.018
cellular macromolecule catabolic process	GO:0044265	136	0.018
brain development	GO:0007420	120	0.018
reproductive system development	GO:0061458	74	0.018
phagocytosis	GO:0006909	215	0.017
cytokinesis	GO:0000910	90	0.017
guanosine containing compound metabolic process	GO:1901068	74	0.017
immune system process	GO:0002376	347	0.017
branching morphogenesis of an epithelial tube	GO:0048754	45	0.017
cuticle development	GO:0042335	86	0.017
cell type specific apoptotic process	GO:0097285	38	0.017
regulation of embryonic development	GO:0045995	68	0.017
compound eye photoreceptor cell differentiation	GO:0001751	140	0.017
trna processing	GO:0008033	3	0.017
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.016
imaginal disc derived wing morphogenesis	GO:0007476	337	0.016
regulation of transport	GO:0051049	181	0.016
border follicle cell migration	GO:0007298	113	0.016
regulation of translation	GO:0006417	56	0.016
oocyte differentiation	GO:0009994	145	0.016
ncrna processing	GO:0034470	30	0.016
embryonic development via the syncytial blastoderm	GO:0001700	148	0.016
positive regulation of multicellular organismal process	GO:0051240	143	0.016
regulation of programmed cell death	GO:0043067	152	0.016
cellular response to organic substance	GO:0071310	132	0.015
branching involved in open tracheal system development	GO:0060446	45	0.015
positive regulation of cell communication	GO:0010647	250	0.015
developmental growth	GO:0048589	280	0.015
cellular amino acid metabolic process	GO:0006520	61	0.015
establishment of protein localization	GO:0045184	163	0.015
development of primary sexual characteristics	GO:0045137	50	0.015
nucleoside phosphate catabolic process	GO:1901292	110	0.015
growth	GO:0040007	359	0.014
golgi vesicle transport	GO:0048193	27	0.014
regulation of establishment of protein localization	GO:0070201	61	0.014
protein import	GO:0017038	55	0.014
oxoacid metabolic process	GO:0043436	103	0.014
response to other organism	GO:0051707	293	0.014
appendage development	GO:0048736	401	0.014
response to external biotic stimulus	GO:0043207	293	0.014
organelle localization	GO:0051640	148	0.014
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.014
regulation of embryonic pattern specification	GO:1902875	27	0.014
purine ribonucleoside catabolic process	GO:0046130	112	0.014
negative regulation of response to stimulus	GO:0048585	258	0.013
regulation of behavior	GO:0050795	75	0.013
gland morphogenesis	GO:0022612	145	0.013
compound eye photoreceptor development	GO:0042051	78	0.013
digestive tract development	GO:0048565	149	0.013
reproductive structure development	GO:0048608	74	0.013
ameboidal type cell migration	GO:0001667	151	0.013
chromosome organization	GO:0051276	360	0.013
cellular response to chemical stimulus	GO:0070887	199	0.013
posttranscriptional regulation of gene expression	GO:0010608	145	0.012
ribonucleotide catabolic process	GO:0009261	109	0.012
compound eye morphogenesis	GO:0001745	249	0.012
purine ribonucleotide catabolic process	GO:0009154	109	0.012
dorsal ventral axis specification	GO:0009950	66	0.012
sex differentiation	GO:0007548	81	0.012
photoreceptor cell development	GO:0042461	96	0.012
regulation of cellular component biogenesis	GO:0044087	201	0.012
epithelial cell differentiation	GO:0030855	322	0.012
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.012
negative regulation of rna metabolic process	GO:0051253	251	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.012
necrotic cell death	GO:0070265	1	0.012
negative regulation of gene expression	GO:0010629	387	0.012
negative regulation of transcription dna templated	GO:0045892	237	0.012
cytoplasmic microtubule organization	GO:0031122	22	0.011
single organism intracellular transport	GO:1902582	207	0.011
telencephalon development	GO:0021537	2	0.011
macromolecular complex disassembly	GO:0032984	37	0.011
cellular response to dna damage stimulus	GO:0006974	223	0.011
positive regulation of cell development	GO:0010720	61	0.011
regulation of wnt signaling pathway	GO:0030111	68	0.011
aging	GO:0007568	143	0.011
regulation of epithelial cell proliferation	GO:0050678	4	0.011
vesicle mediated transport	GO:0016192	381	0.011
positive regulation of cell migration	GO:0030335	2	0.011
regulation of mitochondrial fission	GO:0090140	7	0.011
cellular nitrogen compound catabolic process	GO:0044270	165	0.011
organelle fission	GO:0048285	340	0.010
protein alkylation	GO:0008213	43	0.010
peptidyl serine phosphorylation	GO:0018105	7	0.010
spermatogenesis	GO:0007283	200	0.010

Aats-trp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of cellular proliferation	DOID:14566	0	0.013

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