IMP: Integrative Multi-species Prediction

Drosophila melanogaster

209 known processes

rept (Dmel_CG9750)

reptin

(Aliases: Rept,Tip48/Reptin,dRep,rep,CG9750,Dmel\CG9750,anon-WO0142479.1,Tip48,dReptin,Reptin,drep,l(3)06945)

FLYBASE: FBgn0040075
Entrez: 40092
UniProtKB: Q9V3K3
UniProtKB: M9PFN1

Process Predictions
Disease Predictions

rept biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
growth	GO:0040007	359	0.880
negative regulation of cellular metabolic process	GO:0031324	382	0.842
negative regulation of rna metabolic process	GO:0051253	251	0.826
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.806
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.717
nucleosome organization	GO:0034728	59	0.686
regulation of gene expression epigenetic	GO:0040029	128	0.663
negative regulation of cellular biosynthetic process	GO:0031327	277	0.657
ribosomal large subunit biogenesis	GO:0042273	1	0.608
regulation of cell cycle phase transition	GO:1901987	130	0.594
cellular response to dna damage stimulus	GO:0006974	223	0.579
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.564
immune system process	GO:0002376	347	0.532
dna metabolic process	GO:0006259	227	0.509
mitotic cell cycle phase transition	GO:0044772	138	0.492
mitotic dna damage checkpoint	GO:0044773	74	0.462
cell cycle phase transition	GO:0044770	140	0.390
heterocycle catabolic process	GO:0046700	166	0.354
mitotic g2 m transition checkpoint	GO:0044818	70	0.352
developmental growth	GO:0048589	280	0.337
histone exchange	GO:0043486	21	0.337
chromosome organization	GO:0051276	360	0.318
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.285
organic cyclic compound catabolic process	GO:1901361	168	0.280
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.274
single organism catabolic process	GO:0044712	228	0.232
chromatin assembly or disassembly	GO:0006333	52	0.225
atp dependent chromatin remodeling	GO:0043044	22	0.224
small molecule metabolic process	GO:0044281	305	0.213
cellular nitrogen compound catabolic process	GO:0044270	165	0.208
mrna splice site selection	GO:0006376	1	0.201
mrna metabolic process	GO:0016071	124	0.198
negative regulation of rna biosynthetic process	GO:1902679	240	0.198
macromolecular complex assembly	GO:0065003	256	0.195
spermatogenesis	GO:0007283	200	0.195
regulation of cell cycle process	GO:0010564	181	0.190
rna interference	GO:0016246	27	0.189	Worm
negative regulation of cell cycle process	GO:0010948	109	0.187
mitotic dna integrity checkpoint	GO:0044774	75	0.184
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.182
regulation of meiosis	GO:0040020	3	0.181
negative regulation of gene expression	GO:0010629	387	0.179
catabolic process	GO:0009056	409	0.167
chromatin remodeling	GO:0006338	72	0.165
regulation of multicellular organism growth	GO:0040014	40	0.158
cell proliferation	GO:0008283	299	0.157
male gamete generation	GO:0048232	201	0.150
spindle assembly involved in mitosis	GO:0090307	50	0.147
body morphogenesis	GO:0010171	2	0.142
negative regulation of cell cycle phase transition	GO:1901988	103	0.138
rna processing	GO:0006396	147	0.138
gene silencing	GO:0016458	138	0.136
regulation of cell cycle	GO:0051726	291	0.121
embryonic development via the syncytial blastoderm	GO:0001700	148	0.116
g2 dna damage checkpoint	GO:0031572	69	0.116
cellular macromolecular complex assembly	GO:0034622	153	0.115
ribonucleoprotein complex biogenesis	GO:0022613	31	0.114
ribonucleoprotein complex subunit organization	GO:0071826	28	0.111
striated muscle myosin thick filament assembly	GO:0071688	3	0.110
regulation of mitotic cell cycle	GO:0007346	190	0.106
cellular catabolic process	GO:0044248	372	0.102
posttranscriptional gene silencing	GO:0016441	46	0.101	Worm
negative regulation of biosynthetic process	GO:0009890	277	0.101
cell death	GO:0008219	279	0.101
mitotic g2 dna damage checkpoint	GO:0007095	69	0.099
programmed cell death	GO:0012501	257	0.098
dna damage checkpoint	GO:0000077	78	0.094
negative regulation of gene expression epigenetic	GO:0045814	77	0.094
protein modification by small protein conjugation or removal	GO:0070647	106	0.092
regulation of intracellular signal transduction	GO:1902531	236	0.091
mitotic cell cycle checkpoint	GO:0007093	88	0.088
positive regulation of macromolecule metabolic process	GO:0010604	405	0.088
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.088
mrna catabolic process	GO:0006402	33	0.080
organelle assembly	GO:0070925	198	0.079
spermatid differentiation	GO:0048515	114	0.079
cell cycle checkpoint	GO:0000075	95	0.078
gene silencing by rna	GO:0031047	57	0.078	Worm
dendrite morphogenesis	GO:0048813	199	0.078
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.077
organic substance catabolic process	GO:1901575	308	0.076
positive regulation of gene expression	GO:0010628	290	0.076
protein ubiquitination	GO:0016567	70	0.076
protein dna complex assembly	GO:0065004	63	0.076
regulation of developmental growth	GO:0048638	174	0.076
chromatin silencing	GO:0006342	76	0.074
protein dna complex subunit organization	GO:0071824	86	0.074
establishment of localization in cell	GO:0051649	402	0.071
protein modification by small protein conjugation	GO:0032446	79	0.071
multicellular organism growth	GO:0035264	46	0.070
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.068
nucleoside metabolic process	GO:0009116	127	0.068
regulation of ras protein signal transduction	GO:0046578	93	0.065
single organism biosynthetic process	GO:0044711	206	0.062
rna catabolic process	GO:0006401	37	0.061
oxoacid metabolic process	GO:0043436	103	0.060
internal protein amino acid acetylation	GO:0006475	38	0.059
regulation of protein metabolic process	GO:0051246	256	0.058
positive regulation of rna metabolic process	GO:0051254	271	0.057
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.056
organonitrogen compound catabolic process	GO:1901565	128	0.056
dna integrity checkpoint	GO:0031570	81	0.056
aromatic compound catabolic process	GO:0019439	166	0.054
spermatid development	GO:0007286	98	0.053
positive regulation of transcription dna templated	GO:0045893	266	0.053
ras protein signal transduction	GO:0007265	88	0.052
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.052
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.050
response to external biotic stimulus	GO:0043207	293	0.050
death	GO:0016265	284	0.050
regulation of cell proliferation	GO:0042127	163	0.050
rna splicing	GO:0008380	83	0.049
regulation of molecular function	GO:0065009	217	0.048
nucleoside phosphate catabolic process	GO:1901292	110	0.048
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.047
positive regulation of biosynthetic process	GO:0009891	316	0.045
organophosphate metabolic process	GO:0019637	195	0.044
phagocytosis	GO:0006909	215	0.044
internal peptidyl lysine acetylation	GO:0018393	38	0.044
tube development	GO:0035295	244	0.043
positive regulation of cellular biosynthetic process	GO:0031328	316	0.043
meiotic cell cycle	GO:0051321	171	0.042
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.042
chromatin organization	GO:0006325	207	0.041
nucleoside triphosphate catabolic process	GO:0009143	108	0.040
nuclear transport	GO:0051169	72	0.040
negative regulation of mitotic cell cycle	GO:0045930	109	0.040
mrna splicing via spliceosome	GO:0000398	73	0.039
response to abiotic stimulus	GO:0009628	341	0.039
regulation of growth	GO:0040008	233	0.039
regulation of heterochromatin assembly	GO:0031445	8	0.038
purine containing compound metabolic process	GO:0072521	155	0.037
organonitrogen compound metabolic process	GO:1901564	318	0.036
intracellular transport	GO:0046907	228	0.036
apoptotic process	GO:0006915	159	0.036
reproductive structure development	GO:0048608	74	0.035	Worm
axon development	GO:0061564	297	0.035
positive regulation of molecular function	GO:0044093	136	0.035
dendrite development	GO:0016358	204	0.035
nucleosome positioning	GO:0016584	3	0.035
nucleobase containing compound catabolic process	GO:0034655	165	0.034
ribonucleoside catabolic process	GO:0042454	112	0.034
mitotic sister chromatid segregation	GO:0000070	87	0.034
intracellular signal transduction	GO:0035556	300	0.034
ribonucleoprotein complex assembly	GO:0022618	23	0.034
nucleotide catabolic process	GO:0009166	109	0.033
genitalia development	GO:0048806	26	0.033	Worm
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.033
rna splicing via transesterification reactions	GO:0000375	73	0.032
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.032
organic substance transport	GO:0071702	257	0.032
nucleoside catabolic process	GO:0009164	112	0.032
purine nucleotide catabolic process	GO:0006195	109	0.031
small gtpase mediated signal transduction	GO:0007264	88	0.030
transcription from rna polymerase ii promoter	GO:0006366	368	0.030
immune response	GO:0006955	246	0.030
purine ribonucleoside metabolic process	GO:0046128	127	0.029
regulation of cell differentiation	GO:0045595	302	0.029
dna conformation change	GO:0071103	105	0.029
establishment of organelle localization	GO:0051656	122	0.028
regulation of cell death	GO:0010941	173	0.028
positive regulation of immune response	GO:0050778	63	0.028
protein acetylation	GO:0006473	39	0.027
positive regulation of response to stimulus	GO:0048584	323	0.027
glycosyl compound catabolic process	GO:1901658	112	0.027
peptidyl lysine dimethylation	GO:0018027	3	0.027
defense response to other organism	GO:0098542	225	0.027
regulation of cellular protein metabolic process	GO:0032268	243	0.027
methylation	GO:0032259	47	0.026
mrna processing	GO:0006397	104	0.026
regulation of nuclear division	GO:0051783	58	0.025
nucleosome mobilization	GO:0042766	9	0.025
mitotic nuclear division	GO:0007067	213	0.024
dendrite guidance	GO:0070983	21	0.024
regulation of catabolic process	GO:0009894	170	0.024
development of primary sexual characteristics	GO:0045137	50	0.024	Worm
purine nucleotide metabolic process	GO:0006163	146	0.024
nucleotide metabolic process	GO:0009117	161	0.023
glycosyl compound metabolic process	GO:1901657	127	0.023
protein maturation	GO:0051604	71	0.023
purine nucleoside metabolic process	GO:0042278	127	0.022
organophosphate catabolic process	GO:0046434	112	0.022
positive regulation of intracellular signal transduction	GO:1902533	116	0.022
endocytosis	GO:0006897	310	0.022	Worm
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.022
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.022
ribose phosphate metabolic process	GO:0019693	145	0.022
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.021
regulation of organelle organization	GO:0033043	196	0.021
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.021
purine nucleoside catabolic process	GO:0006152	112	0.021
positive regulation of multicellular organism growth	GO:0040018	21	0.021
organic acid metabolic process	GO:0006082	103	0.021
histone methylation	GO:0016571	40	0.021
chromosome separation	GO:0051304	42	0.020
embryonic morphogenesis	GO:0048598	206	0.020
negative regulation of developmental process	GO:0051093	201	0.020
embryo development ending in birth or egg hatching	GO:0009792	152	0.020	Worm
ribonucleotide metabolic process	GO:0009259	145	0.020
single organism intracellular transport	GO:1902582	207	0.019
posttranscriptional gene silencing by rna	GO:0035194	45	0.019	Worm
heterochromatin organization	GO:0070828	25	0.019
maintenance of location	GO:0051235	73	0.019
dna biosynthetic process	GO:0071897	24	0.019
dna replication	GO:0006260	48	0.019
protein transport	GO:0015031	155	0.019
purine ribonucleotide catabolic process	GO:0009154	109	0.019
ncrna metabolic process	GO:0034660	43	0.018
response to temperature stimulus	GO:0009266	106	0.018
protein import	GO:0017038	55	0.018
negative regulation of cell cycle	GO:0045786	116	0.018
histone h4 k20 methylation	GO:0034770	4	0.018
regulation of catalytic activity	GO:0050790	185	0.018
translational termination	GO:0006415	2	0.018
spliceosomal snrnp assembly	GO:0000387	2	0.018
regulation of cell division	GO:0051302	72	0.018
nuclear division	GO:0000280	332	0.018
positive regulation of hydrolase activity	GO:0051345	78	0.018
lipid localization	GO:0010876	54	0.018
regulation of mrna metabolic process	GO:1903311	72	0.018
multi multicellular organism process	GO:0044706	123	0.017
positive regulation of programmed cell death	GO:0043068	62	0.017
cellular macromolecule catabolic process	GO:0044265	136	0.017
cytoplasmic transport	GO:0016482	130	0.017
dna methylation or demethylation	GO:0044728	4	0.017
macromolecular complex disassembly	GO:0032984	37	0.017
regulation of hydrolase activity	GO:0051336	97	0.017
purine ribonucleoside catabolic process	GO:0046130	112	0.016
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.016
histone h2a acetylation	GO:0043968	1	0.016
negative regulation of transcription dna templated	GO:0045892	237	0.016
negative regulation of cell differentiation	GO:0045596	143	0.016
positive regulation of signal transduction	GO:0009967	223	0.016
positive regulation of rna biosynthetic process	GO:1902680	266	0.016
eye development	GO:0001654	323	0.016
protein complex disassembly	GO:0043241	36	0.016
defense response to bacterium	GO:0042742	178	0.015
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.015
mitotic chromosome condensation	GO:0007076	22	0.015
positive regulation of immune system process	GO:0002684	68	0.015
atp metabolic process	GO:0046034	49	0.015
purine ribonucleotide metabolic process	GO:0009150	145	0.015
positive regulation of heterochromatin assembly	GO:0031453	5	0.014
g2 m transition of mitotic cell cycle	GO:0000086	19	0.014
atp catabolic process	GO:0006200	38	0.014
vesicle mediated transport	GO:0016192	381	0.014	Worm
nucleoside monophosphate metabolic process	GO:0009123	52	0.014
ribonucleotide catabolic process	GO:0009261	109	0.014
sex differentiation	GO:0007548	81	0.014	Worm
tube morphogenesis	GO:0035239	191	0.014
positive regulation of signaling	GO:0023056	243	0.014
nuclear export	GO:0051168	24	0.014
chromatin assembly	GO:0031497	48	0.013
positive regulation of catalytic activity	GO:0043085	118	0.013
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.013
regulation of dna metabolic process	GO:0051052	34	0.013
larval development	GO:0002164	104	0.013	Worm
positive regulation of proteolysis	GO:0045862	52	0.013
negative regulation of dna metabolic process	GO:0051053	12	0.013
carbohydrate derivative metabolic process	GO:1901135	217	0.013
positive regulation of protein metabolic process	GO:0051247	128	0.013
regulation of programmed cell death	GO:0043067	152	0.013
carbohydrate derivative catabolic process	GO:1901136	118	0.013
cell growth	GO:0016049	108	0.012
chromosome segregation	GO:0007059	157	0.012
tissue death	GO:0016271	102	0.012
metaphase anaphase transition of cell cycle	GO:0044784	28	0.012
response to oxygen containing compound	GO:1901700	200	0.012
protein complex biogenesis	GO:0070271	201	0.012
regulation of meiotic cell cycle	GO:0051445	9	0.012
ribonucleoside metabolic process	GO:0009119	127	0.012
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.012
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.012
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.012
negative regulation of meiotic cell cycle	GO:0051447	2	0.012
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.012
positive regulation of growth	GO:0045927	75	0.012
nucleoside triphosphate metabolic process	GO:0009141	120	0.012
positive regulation of catabolic process	GO:0009896	105	0.012
aging	GO:0007568	143	0.012
regulation of mitotic sister chromatid separation	GO:0010965	28	0.012
regulation of proteolysis	GO:0030162	87	0.012
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.011
cellular response to nutrient	GO:0031670	1	0.011
gonad development	GO:0008406	50	0.011	Worm
regulation of homotypic cell cell adhesion	GO:0034110	2	0.011
negative regulation of neurogenesis	GO:0050768	53	0.011
cellular component assembly involved in morphogenesis	GO:0010927	151	0.011
positive regulation of binding	GO:0051099	4	0.011
positive regulation of developmental growth	GO:0048639	62	0.011
regulation of rna splicing	GO:0043484	69	0.011
nucleocytoplasmic transport	GO:0006913	72	0.011
ribosome biogenesis	GO:0042254	8	0.011
cell migration	GO:0016477	238	0.011
neuron recognition	GO:0008038	101	0.011
meiotic nuclear division	GO:0007126	151	0.011
nucleoside monophosphate catabolic process	GO:0009125	39	0.011
mitotic sister chromatid separation	GO:0051306	30	0.011
regulation of imaginal disc growth	GO:0045570	26	0.011
regulation of growth rate	GO:0040009	3	0.011
histone acetylation	GO:0016573	38	0.011
negative regulation of response to extracellular stimulus	GO:0032105	6	0.010
negative regulation of neuroblast proliferation	GO:0007406	27	0.010
positive regulation of cell communication	GO:0010647	250	0.010
peptidyl amino acid modification	GO:0018193	105	0.010
oviposition	GO:0018991	19	0.010
sister chromatid segregation	GO:0000819	92	0.010
cellular protein modification process	GO:0006464	438	0.010
regulation of apoptotic process	GO:0042981	130	0.010

rept disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.041

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