Homo sapiens

12 known processes

SCN9A

sodium channel, voltage-gated, type IX, alpha subunit

(Aliases: Nav1.7,PN1,NENA,NE-NA,ETHA,FEB3B)

SCN9A biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.078
amine metabolic processGO:0009308440.076
cellular amine metabolic processGO:0044106410.073
regulation of cellular amine metabolic processGO:0033238110.068
post embryonic developmentGO:000979120.067
regulation of cellular ketone metabolic processGO:0010565500.066
cellular ketone metabolic processGO:0042180800.064
regulation of cellular amino acid metabolic processGO:000652160.062
positive regulation of cellular amino acid metabolic processGO:004576430.059
positive regulation of cellular amine metabolic processGO:003324070.051
locomotory behaviorGO:000762610.047
ras protein signal transductionGO:0007265730.044
system processGO:00030083490.044
Human Rat
positive regulation of phosphorylationGO:00423273940.043
small gtpase mediated signal transductionGO:0007264780.042
positive regulation of transportGO:00510503360.042
organophosphate catabolic processGO:00464344300.041
purine containing compound catabolic processGO:00725234110.040
multicellular organismal agingGO:001025930.039
nucleoside phosphate catabolic processGO:19012924120.039
nucleoside triphosphate metabolic processGO:00091414220.038
cation transportGO:00068123310.038
Human Rat
positive regulation of cellular component organizationGO:00511303760.037
purine ribonucleoside metabolic processGO:00461284370.037
ribonucleoside triphosphate metabolic processGO:00091994120.037
lipid metabolic processGO:00066293810.037
purine nucleotide catabolic processGO:00061954050.037
determination of adult lifespanGO:000834020.036
nucleotide catabolic processGO:00091664080.036
purine ribonucleoside catabolic processGO:00461303980.036
chemical homeostasisGO:00488783060.036
Human
glycosyl compound catabolic processGO:19016584130.035
transmembrane transportGO:00550853990.035
Human Rat
purine nucleoside triphosphate metabolic processGO:00091444120.035
immune responseGO:00069553070.035
ribonucleoside triphosphate catabolic processGO:00092033910.035
purine ribonucleotide catabolic processGO:00091544040.035
nervous system developmentGO:00073992930.034
female gamete generationGO:000729220.034
ribonucleotide catabolic processGO:00092614050.034
negative regulation of protein metabolic processGO:00512483910.034
purine ribonucleoside triphosphate metabolic processGO:00092054110.034
regulation of cell differentiationGO:00455953930.034
negative regulation of cellular protein metabolic processGO:00322693530.034
nucleoside triphosphate catabolic processGO:00091433940.034
signal transduction by phosphorylationGO:00230142970.034
positive regulation of protein phosphorylationGO:00019343130.033
purine nucleoside triphosphate catabolic processGO:00091463920.033
purine ribonucleoside triphosphate catabolic processGO:00092073910.033
ribonucleoside catabolic processGO:00424544060.033
single organism membrane organizationGO:00448022680.033
vesicle mediated transportGO:00161923710.033
purine nucleoside catabolic processGO:00061523980.032
positive regulation of hydrolase activityGO:00513453310.032
regulation of transferase activityGO:00513383550.032
neuromuscular junction developmentGO:000752830.032
response to oxygen containing compoundGO:19017003690.031
ion transmembrane transportGO:00342203380.031
Human Rat
defense responseGO:00069523150.031
memoryGO:000761330.031
nucleoside catabolic processGO:00091644080.031
oogenesisGO:004847720.031
negative regulation of catalytic activityGO:00430863350.031
cellular lipid metabolic processGO:00442553030.031
mapk cascadeGO:00001652880.030
positive regulation of synaptic transmissionGO:005080640.030
regulation of nucleotide metabolic processGO:00061402690.030
cell adhesionGO:00071553250.030
regulation of cellular component movementGO:00512703340.030
ion homeostasisGO:00508012300.030
Human
positive regulation of catabolic processGO:00098963100.029
segmentationGO:003528240.029
rho protein signal transductionGO:0007266260.029
regulation of locomotionGO:00400123290.029
negative regulation of multicellular organismal processGO:00512413170.029
cytoplasmic transportGO:00164823790.029
regenerationGO:003109940.029
single organism cellular localizationGO:19025803320.029
positive regulation of cellular catabolic processGO:00313312840.029
response to abiotic stimulusGO:00096283360.029
regulation of kinase activityGO:00435493140.028
cellular response to endogenous stimulusGO:00714953360.028
membrane organizationGO:00610242920.028
regulation of mapk cascadeGO:00434082620.028
regulation of purine nucleotide metabolic processGO:19005422640.028
negative regulation of phosphorus metabolic processGO:00105632670.028
cell morphogenesisGO:00009022960.027
regulation of cellular component biogenesisGO:00440872810.027
cellular response to oxygen containing compoundGO:19017012760.027
organonitrogen compound biosynthetic processGO:19015662000.027
cell developmentGO:00484683280.027
metal ion transportGO:00300012720.027
Human Rat
actin filament based processGO:00300292240.027
carbohydrate derivative biosynthetic processGO:19011372070.027
regulation of cell migrationGO:00303342890.027
g protein coupled receptor signaling pathwayGO:00071862070.026
biological adhesionGO:00226103310.026
secretionGO:00469032540.026
cellular component morphogenesisGO:00329893140.026
cation transmembrane transportGO:00986552380.026
Human Rat
regulation of cell motilityGO:20001452990.026
negative regulation of cell deathGO:00605483450.026
secretion by cellGO:00329402260.025
negative regulation of phosphate metabolic processGO:00459362670.025
positive regulation of developmental processGO:00510943140.025
cell projection organizationGO:00300302520.025
cation homeostasisGO:00550801890.025
positive regulation of purine nucleotide metabolic processGO:19005442270.025
regulation of protein kinase activityGO:00458592890.025
positive regulation of immune system processGO:00026842830.025
regulation of protein localizationGO:00328802960.025
positive regulation of nucleotide metabolic processGO:00459812300.025
neurological system processGO:00508771630.025
Rat
guanosine containing compound metabolic processGO:19010682440.025
cellular macromolecule catabolic processGO:00442653800.025
regulation of response to external stimulusGO:00321012220.024
regulation of cell cycleGO:00517263930.024
protein catabolic processGO:00301633250.024
cellular homeostasisGO:00197251960.024
metal ion homeostasisGO:00550651690.024
enzyme linked receptor protein signaling pathwayGO:00071673030.024
adult locomotory behaviorGO:000834410.024
cellular chemical homeostasisGO:00550821800.024
regulation of establishment of protein localizationGO:00702012420.024
negative regulation of cellular component organizationGO:00511292350.024
gtp catabolic processGO:00061842370.024
regulation of anatomical structure morphogenesisGO:00226032860.024
guanosine containing compound catabolic processGO:19010692390.024
carbohydrate metabolic processGO:00059752070.024
positive regulation of cell proliferationGO:00082843010.023
hindbrain developmentGO:003090230.023
negative regulation of programmed cell deathGO:00430693210.023
inorganic ion transmembrane transportGO:00986602310.023
Human Rat
gtp metabolic processGO:00460392390.023
negative regulation of cellular amine metabolic processGO:003323930.023
regulation of cellular response to stressGO:00801352440.023
protein maturationGO:00516042330.023
dephosphorylationGO:00163112090.023
regulation of proteolysisGO:00301622930.022
positive regulation of cell differentiationGO:00455972110.022
blastoderm segmentationGO:000735020.022
cellular macromolecular complex assemblyGO:00346223240.022
innate immune responseGO:00450871780.022
intracellular protein transportGO:00068862700.022
positive regulation of transferase activityGO:00513472270.022
protein localization to organelleGO:00333652800.022
negative regulation of apoptotic processGO:00430663160.022
endomembrane system organizationGO:00102561960.022
single organism carbohydrate metabolic processGO:00447231930.021
regulation of ion transportGO:00432691890.021
Human Rat
inorganic cation transmembrane transportGO:00986621940.021
Human Rat
regulation of synaptic plasticityGO:004816730.021
cellular cation homeostasisGO:00300031630.021
negative regulation of cellular amino acid metabolic processGO:004576320.021
response to cytokineGO:00340972320.021
regulation of nucleoside metabolic processGO:00091182090.021
response to biotic stimulusGO:00096072760.021
regulation of secretionGO:00510461940.021
cellular protein catabolic processGO:00442572610.021
cellular ion homeostasisGO:00068731680.021
response to external biotic stimulusGO:00432072610.021
apoptotic signaling pathwayGO:00971902680.021
organophosphate biosynthetic processGO:00904071630.021
regulation of secretion by cellGO:19035301770.021
positive regulation of nucleotide catabolic processGO:00308131850.021
anion transportGO:00068201610.020
positive regulation of nucleoside metabolic processGO:00459791860.020
cytokine productionGO:00018162470.020
positive regulation of purine nucleotide catabolic processGO:00331231850.020
nerve developmentGO:002167540.020
small molecule biosynthetic processGO:00442831570.020
positive regulation of cell deathGO:00109422630.020
positive regulation of kinase activityGO:00336742040.020
regulation of nucleotide catabolic processGO:00308112050.020
nitrogen compound transportGO:00717051910.020
response to organic cyclic compoundGO:00140702040.020
associative learningGO:000830610.020
positive regulation of mapk cascadeGO:00434101900.020
oxidation reduction processGO:00551143960.020
regulation of purine nucleotide catabolic processGO:00331212050.020
cellular response to dna damage stimulusGO:00069743790.020
positive regulation of protein kinase activityGO:00458601900.020
negative regulation of transportGO:00510511760.020
regulation of protein transportGO:00512232130.020
positive regulation of programmed cell deathGO:00430682490.020
protein processingGO:00164852260.020
response to other organismGO:00517072610.020
positive regulation of apoptotic processGO:00430652460.019
neurotransmitter secretionGO:000726940.019
anterior posterior axis specificationGO:000994820.019
mitotic cell cycleGO:00002783260.019
negative regulation of cell proliferationGO:00082852280.019
negative regulation of developmental processGO:00510932470.019
negative regulation of protein modification processGO:00314002000.019
maintenance of locationGO:00512351120.019
cellular metal ion homeostasisGO:00068751460.019
neurogenesisGO:00220081690.019
organic hydroxy compound metabolic processGO:19016151470.019
morphogenesis of embryonic epitheliumGO:001633140.019
regulation of cytokine productionGO:00018172320.019
divalent inorganic cation homeostasisGO:00725071360.019
negative regulation of hydrolase activityGO:00513461820.019
regulation of gtp catabolic processGO:00331241800.019
protein modification by small protein conjugationGO:00324463420.019
regulation of intracellular transportGO:00323861950.019
protein ubiquitinationGO:00165673140.019
anatomical structure formation involved in morphogenesisGO:00486462840.018
regulation of gtpase activityGO:00430871800.018
oocyte developmentGO:004859910.018
lipid biosynthetic processGO:00086101770.018
matingGO:000761810.018
circulatory system developmentGO:00723592620.018
cell fate determinationGO:000170930.018
cardiac muscle cell contractionGO:008600340.018
oocyte differentiationGO:000999420.018
reactive nitrogen species metabolic processGO:200105730.018
peripheral nervous system developmentGO:000742220.018
motor neuron axon guidanceGO:000804520.018
spermatid differentiationGO:004851540.018
response to nitrogen compoundGO:19016981840.018
rhythmic behaviorGO:000762220.018
regulation of immune responseGO:00507762010.018
mitotic cell cycle processGO:19030472860.018
response to growth factorGO:00708482050.018
positive regulation of gtpase activityGO:00435471660.018
regulation of cell cycle processGO:00105642660.018
reactive oxygen species biosynthetic processGO:190340940.018
compound eye developmentGO:004874910.018
limbic system developmentGO:002176130.018
negative regulation of intracellular signal transductionGO:19025321830.018
growthGO:00400072020.018
monocarboxylic acid metabolic processGO:00327871850.018
protein oligomerizationGO:00512591730.017
cellular response to growth factor stimulusGO:00713631970.017
proteolysis involved in cellular protein catabolic processGO:00516032440.017
response to lipidGO:00339932060.017
response to hormoneGO:00097251750.017
regulation of membrane potentialGO:0042391950.017
Human Rat
photoreceptor cell differentiationGO:004653020.017
response to woundingGO:00096111680.017
cellular protein complex assemblyGO:00436231880.017
positive regulation of cellular component movementGO:00512721810.017
positive regulation of gtp catabolic processGO:00331261660.017
positive regulation of locomotionGO:00400171860.017
regulation of cytoskeleton organizationGO:00514931770.017
regulation of small gtpase mediated signal transductionGO:00510561560.017
organ formationGO:004864530.017
calcium ion transportGO:00068161470.017
reactive oxygen species metabolic processGO:0072593750.017
protein targetingGO:00066051870.017
positive regulation of cell migrationGO:00303351720.017
regulation of cell developmentGO:00602841610.017
negative regulation of phosphorylationGO:00423261740.016
tripartite regional subdivisionGO:000735120.016
generation of neuronsGO:00486991520.016
regulation of sequence specific dna binding transcription factor activityGO:00510902110.016
response to axon injuryGO:004867810.016
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.016
cardiovascular system developmentGO:00723582620.016
peptidyl tyrosine modificationGO:00182121700.016
positive regulation of organelle organizationGO:00106381950.016
regulation of growthGO:00400081650.016
actin cytoskeleton organizationGO:00300362070.016
embryonic epithelial tube formationGO:000183840.016
peptidyl tyrosine phosphorylationGO:00181081700.016
calcium ion homeostasisGO:00550741220.016
divalent inorganic cation transportGO:00725111580.016
circadian behaviorGO:004851220.016
metencephalon developmentGO:002203720.016
regulation of reactive oxygen species biosynthetic processGO:190342630.016
cell activationGO:00017752130.016
microtubule based processGO:00070172100.016
release of cytoplasmic sequestered nf kappabGO:000858840.016
positive regulation of cell motilityGO:20001471770.016
protein localization to membraneGO:00726571600.016
spermatid developmentGO:000728640.016
posttranscriptional regulation of gene expressionGO:00106082130.016
epithelium developmentGO:00604292270.016
sensory perception of painGO:001923340.016
regulation of ras protein signal transductionGO:00465781550.016
immune system developmentGO:00025201950.016
single organism cell adhesionGO:00986021790.016
startle responseGO:000196430.016
ribonucleoside monophosphate metabolic processGO:00091611870.015
regulation of ion transmembrane transportGO:00347651320.015
Human Rat
cell growthGO:00160491600.015
divalent metal ion transportGO:00708381520.015
muscle contractionGO:0006936730.015
Human
regulation of neural precursor cell proliferationGO:200017740.015
sequestering of metal ionGO:0051238240.015
neuroblast proliferationGO:000740540.015
muscle system processGO:0003012810.015
Human
cellular calcium ion homeostasisGO:00068741170.015
regulation of endopeptidase activityGO:00525481700.015
purine nucleoside monophosphate metabolic processGO:00091261860.015
regulation of neurotransmitter secretionGO:004692830.015
cellular divalent inorganic cation homeostasisGO:00725031280.015
positive regulation of secretion by cellGO:19035321080.015
visual behaviorGO:000763220.015
cellular response to cytokine stimulusGO:00713451810.015
regulation of cell adhesionGO:00301551660.015
regulation of protein maturationGO:19033171500.015
inner ear morphogenesisGO:004247240.015
nuclear transportGO:00511691790.015
syncytium formation by plasma membrane fusionGO:000076820.015
sensory perception of smellGO:000760820.015
purine ribonucleoside monophosphate metabolic processGO:00091671860.015
positive regulation of cellular component biogenesisGO:00440891580.015
regulation of multi organism processGO:00439001570.015
organic acid biosynthetic processGO:0016053970.015
anterior posterior axis specification embryoGO:000859520.015
response to organonitrogen compoundGO:00102431560.015
nucleotide biosynthetic processGO:00091651090.015
positive regulation of secretionGO:00510471160.015
establishment of protein localization to organelleGO:00725941720.015
cerebellum developmentGO:002154920.015
nucleoside monophosphate metabolic processGO:00091231910.015
regulation of protein catabolic processGO:00421761550.015
modification dependent macromolecule catabolic processGO:00436322120.015
negative regulation of cell cycleGO:00457861930.015
regulation of vesicle mediated transportGO:00606271300.015
interspecies interaction between organismsGO:00444191560.014
carboxylic acid biosynthetic processGO:0046394970.014
tissue regenerationGO:004224630.014
regulation of protein processingGO:00706131500.014
regulation of cell morphogenesisGO:00226041530.014
chromatin modificationGO:00165682980.014
glycoprotein metabolic processGO:00091001100.014
nucleocytoplasmic transportGO:00069131760.014
regulation of ras gtpase activityGO:00323181280.014
chromatin organizationGO:00063253510.014
sequestering of calcium ionGO:0051208170.014
regulation of protein serine threonine kinase activityGO:00719001790.014
positive regulation of ras gtpase activityGO:00323201170.014
neuron differentiationGO:00301821380.014
cell cell signalingGO:00072671550.014
histone modificationGO:00165702510.014
hemopoiesisGO:00300971800.014
positive regulation of protein transportGO:00512221350.014
circulatory system processGO:00030131130.014
Human
response to radiationGO:00093141510.014
atp metabolic processGO:00460341760.014
proteasomal protein catabolic processGO:00104981760.014
modification dependent protein catabolic processGO:00199412090.014
immune effector processGO:00022521590.014
actin mediated cell contractionGO:0070252120.014
blood vessel developmentGO:00015681720.014
multi organism cellular processGO:00447641560.014
ubiquitin dependent protein catabolic processGO:00065112060.014
spinal cord developmentGO:002151040.014
cyclic nucleotide metabolic processGO:0009187820.014
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.014
hematopoietic or lymphoid organ developmentGO:00485341860.014
single organismal cell cell adhesionGO:00163371480.014
viral processGO:00160321460.014
negative regulation of protein phosphorylationGO:00019331400.014
monovalent inorganic cation transportGO:00156721280.014
Human Rat
positive regulation of immune responseGO:00507781590.014
regulation of peptidase activityGO:00525471800.014
regulation of defense responseGO:00313471540.014
response to fungusGO:000962040.014
postsynaptic membrane organizationGO:000194120.014
neuron projection regenerationGO:003110210.014
positive regulation of reactive oxygen species biosynthetic processGO:190342820.014
actin filament based movementGO:0030048170.014
long term memoryGO:000761620.014
sulfur compound metabolic processGO:00067901010.014
regulation of hormone levelsGO:00108171250.014
regulation of cell growthGO:00015581350.014
regulation of metal ion transportGO:00109591200.014
negative regulation of locomotionGO:00400131180.014
nucleoside phosphate biosynthetic processGO:19012931090.014
morphogenesis of a polarized epitheliumGO:000173830.014
organelle assemblyGO:00709251760.014
forebrain generation of neuronsGO:002187230.014
negative regulation of cell migrationGO:00303361020.013
covalent chromatin modificationGO:00165692540.013
cell substrate adhesionGO:00315891320.013
rna processingGO:00063962550.013
alcohol metabolic processGO:00060661140.013
symbiosis encompassing mutualism through parasitismGO:00444031560.013
plasma membrane organizationGO:00070091150.013
regulation of reactive oxygen species metabolic processGO:2000377410.013
taxisGO:00423301570.013
negative regulation of protein maturationGO:19033181420.013
central nervous system developmentGO:00074171230.013
positive regulation of cytokine productionGO:00018191670.013
angiogenesisGO:00015251470.013
negative regulation of proteolysisGO:00458611320.013
myoblast fusionGO:000752010.013
chemotaxisGO:00069351570.013
regulation of protein complex assemblyGO:00432541470.013
sex determinationGO:000753030.013
regulation of cytoplasmic transportGO:19036491490.013
cell part morphogenesisGO:00329901370.013
glial cell migrationGO:000834740.013
endocytosisGO:00068971590.013
negative regulation of immune system processGO:00026831360.013
i kappab kinase nf kappab signalingGO:00072491660.013
regulation of actin filament based processGO:00329701410.013
behaviorGO:00076101120.013
negative regulation of protein processingGO:00109551420.013
cell projection assemblyGO:00300311260.013
rna interferenceGO:001624640.013
blood vessel morphogenesisGO:00485141620.013
nucleoside monophosphate catabolic processGO:00091251590.013
regulation of meiotic cell cycleGO:005144540.013
mitochondrion organizationGO:00070051560.013
regulation of apoptotic signaling pathwayGO:20012331750.013
lung alveolus developmentGO:004828640.013
cellular response to nitrogen compoundGO:19016991440.013
microtubule cytoskeleton organizationGO:00002261760.013
visual learningGO:000854210.013
multicellular organismal response to stressGO:003355510.013
glycerolipid metabolic processGO:00464861070.013
cell cycle phase transitionGO:00447701730.013
regulation of i kappab kinase nf kappab signalingGO:00431221620.013
purine containing compound biosynthetic processGO:0072522880.013
fatty acid metabolic processGO:00066311150.013
response to virusGO:00096151260.013
regulation of cell projection organizationGO:00313441070.013
neuron developmentGO:00486661130.013
salivary gland morphogenesisGO:000743540.013
negative regulation of organelle organizationGO:00106391260.013
positive regulation of reactive oxygen species metabolic processGO:2000379240.013
cell projection morphogenesisGO:00488581290.013
sleepGO:003043120.013
negative regulation of cellular component movementGO:00512711060.012
protein autophosphorylationGO:00467771230.012
establishment of protein localization to membraneGO:00901501210.012
stem cell divisionGO:001714520.012
forebrain neuron differentiationGO:002187930.012
cellular response to organonitrogen compoundGO:00714171240.012
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.012
leukocyte activationGO:00453211640.012
purine nucleotide biosynthetic processGO:0006164840.012
positive regulation of neural precursor cell proliferationGO:200017920.012
negative regulation of cell motilityGO:20001461040.012
neural tube formationGO:000184130.012
specification of organ identityGO:001009230.012
regulation of transmembrane transportGO:00347621390.012
Human Rat
regulation of mitotic cell cycleGO:00073461890.012
cytosolic calcium ion homeostasisGO:0051480890.012
purine ribonucleotide biosynthetic processGO:0009152790.012
negative regulation of synaptic transmissionGO:005080520.012
dna repairGO:00062811980.012
cell morphogenesis involved in differentiationGO:00009041440.012
endosomal transportGO:00161971290.012
striated muscle contractionGO:0006941520.012
Human
somitogenesisGO:000175620.012
regulation of peptidyl tyrosine phosphorylationGO:00507301080.012
cell divisionGO:00513011680.012
neuron projection developmentGO:00311751060.012
ribonucleotide biosynthetic processGO:0009260810.012
protein acylationGO:00435431380.012
regulation of dna metabolic processGO:00510521530.012
ribose phosphate biosynthetic processGO:0046390820.012
response to inorganic substanceGO:00100351270.012
peptidyl serine modificationGO:00182091060.012
protein localization to nucleusGO:00345041360.012
behavioral response to ethanolGO:004814920.012
tube closureGO:006060630.012
activation of immune responseGO:00022531140.012
sensory perceptionGO:00076001030.012
negative regulation of transferase activityGO:00513481240.012
regulation of intracellular protein transportGO:00331571230.012
viral life cycleGO:00190581320.012
primary neural tube formationGO:001402030.012
vasculature developmentGO:00019441810.012
defense response to fungusGO:005083240.012

SCN9A disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.035
Human
musculoskeletal system diseaseDOID:172230.028
Human
inherited metabolic disorderDOID:6552420.027
Human
nervous system diseaseDOID:8634310.024
sensory system diseaseDOID:00501552030.024
central nervous system diseaseDOID:3311860.022
disease of cellular proliferationDOID:145661740.020
cancerDOID:1621670.019
eye and adnexa diseaseDOID:14921500.019
eye diseaseDOID:56141490.018
organ system cancerDOID:00506861640.018
immune system diseaseDOID:29141550.017
retinal diseaseDOID:56791180.016
cardiovascular system diseaseDOID:12871060.016
connective tissue diseaseDOID:651090.016
muscle tissue diseaseDOID:661130.015
Human
muscular diseaseDOID:00800001140.015
Human
myopathyDOID:4231040.015
Human
bone diseaseDOID:0080001880.014
neurodegenerative diseaseDOID:12891020.014
brain diseaseDOID:936730.012
retinal degenerationDOID:8466890.012
hematopoietic system diseaseDOID:741000.012