Homo sapiens

10 known processes

TOPBP1

topoisomerase (DNA) II binding protein 1

(Aliases: TOP2BP1)

TOPBP1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to dna damage stimulusGO:00069743790.992
dna conformation changeGO:00711031130.928
regulation of dna metabolic processGO:00510521530.898
Worm
negative regulation of cell cycleGO:00457861930.895
Fly
meiotic chromosome segregationGO:004513240.864
g2 dna damage checkpointGO:0031572260.837
Fly
regulation of mitotic cell cycleGO:00073461890.801
Fly
organelle fissionGO:00482851490.781
purine ribonucleoside monophosphate catabolic processGO:00091691580.735
dna repairGO:00062811980.727
cell cycle checkpointGO:00000751170.717
Fly
dna recombinationGO:0006310770.698
purine nucleoside monophosphate catabolic processGO:00091281580.656
negative regulation of mitotic cell cycle phase transitionGO:1901991850.638
Fly
ribonucleoside monophosphate catabolic processGO:00091581580.630
apoptotic signaling pathwayGO:00971902680.622
negative regulation of mitotic cell cycleGO:00459301020.585
Fly
negative regulation of cell cycle phase transitionGO:1901988890.545
Fly
chromosome segregationGO:00070591140.514
purine nucleoside monophosphate metabolic processGO:00091261860.496
centrosome cycleGO:0007098320.490
nucleoside monophosphate metabolic processGO:00091231910.471
mitotic dna integrity checkpointGO:0044774300.464
Fly
mitotic cell cycle checkpointGO:0007093680.458
Fly
intrinsic apoptotic signaling pathwayGO:00971931270.455
negative regulation of cell cycle processGO:00109481210.434
Fly
nucleoside triphosphate catabolic processGO:00091433940.431
dna dependent dna replicationGO:0006261440.430
nucleoside monophosphate catabolic processGO:00091251590.418
mitotic cell cycleGO:00002783260.398
Fly
regulation of mitotic cell cycle phase transitionGO:19019901180.395
Fly
regulation of cellular component biogenesisGO:00440872810.346
mitotic dna replication checkpointGO:003331420.313
Fly
mitotic dna damage checkpointGO:0044773280.305
Fly
atp catabolic processGO:00062001570.302
mitotic cell cycle processGO:19030472860.296
Fly
regulation of cell cycleGO:00517263930.287
Fly
double strand break repairGO:00063021010.277
meiosis iGO:000712740.270
ribonucleotide catabolic processGO:00092614050.263
nuclear divisionGO:00002801280.257
post embryonic developmentGO:000979120.255
dna damage checkpointGO:0000077680.245
Fly
regulation of response to dna damage stimulusGO:2001020940.239
ribonucleoside monophosphate metabolic processGO:00091611870.214
regulation of microtubule cytoskeleton organizationGO:0070507610.209
regulation of cell cycle phase transitionGO:19019871260.200
Fly
blastocyst developmentGO:000182430.184
ribonucleoside catabolic processGO:00424544060.181
vesicle mediated transportGO:00161923710.181
regulation of cell divisionGO:00513021160.177
chromosome condensationGO:0030261150.172
purine nucleotide catabolic processGO:00061954050.166
nucleoside triphosphate metabolic processGO:00091414220.164
cellular macromolecule catabolic processGO:00442653800.160
double strand break repair via homologous recombinationGO:0000724500.155
double strand break repair via single strand annealingGO:004500240.152
regulation of double strand break repairGO:2000779220.148
chromatin modificationGO:00165682980.144
cellular amino acid metabolic processGO:00065201160.141
purine ribonucleoside monophosphate metabolic processGO:00091671860.139
purine ribonucleoside metabolic processGO:00461284370.138
regulation of dna dependent dna replicationGO:0090329190.135
recombinational repairGO:0000725500.131
regulation of dna repairGO:0006282470.126
regulation of microtubule based processGO:0032886740.125
mitotic cell cycle phase transitionGO:00447721620.119
Fly
glycosyl compound catabolic processGO:19016584130.119
purine ribonucleoside triphosphate metabolic processGO:00092054110.118
negative regulation of cellular protein metabolic processGO:00322693530.112
female gamete generationGO:000729220.110
regulation of cytoskeleton organizationGO:00514931770.109
positive regulation of cellular amine metabolic processGO:003324070.107
purine nucleoside triphosphate catabolic processGO:00091463920.107
purine nucleoside triphosphate metabolic processGO:00091444120.107
tube developmentGO:00352951250.105
negative regulation of apoptotic processGO:00430663160.103
negative regulation of dna metabolic processGO:0051053570.099
protein autophosphorylationGO:00467771230.095
embryo developmentGO:00097901230.095
Worm
negative regulation of programmed cell deathGO:00430693210.094
somatic recombination of immunoglobulin genes involved in immune responseGO:000220430.093
dna replicationGO:00062601160.092
Worm
regulation of meiotic cell cycleGO:005144540.092
regulation of cellular response to stressGO:00801352440.090
atp metabolic processGO:00460341760.089
nervous system developmentGO:00073992930.086
purine containing compound catabolic processGO:00725234110.085
brain developmentGO:0007420970.084
regulation of protein complex assemblyGO:00432541470.084
mitotic g2 dna damage checkpointGO:000709570.083
Fly
purine ribonucleotide catabolic processGO:00091544040.081
chromatin organizationGO:00063253510.079
purine ribonucleoside catabolic processGO:00461303980.076
mitotic g2 m transition checkpointGO:004481890.075
Fly
nucleotide catabolic processGO:00091664080.070
amine metabolic processGO:0009308440.069
regulation of cell cycle processGO:00105642660.069
Fly
meiotic nuclear divisionGO:0007126100.069
centrosome organizationGO:0051297580.067
head developmentGO:00603221080.064
mitotic nuclear divisionGO:00070671190.063
regulation of intracellular transportGO:00323861950.059
nucleoside phosphate catabolic processGO:19012924120.058
ribonucleoside triphosphate catabolic processGO:00092033910.057
regulation of nuclear divisionGO:0051783650.057
response to nitrogen compoundGO:19016981840.057
microtubule based processGO:00070172100.056
mitotic sister chromatid segregationGO:0000070530.056
reproductive processGO:00224141060.055
negative regulation of catalytic activityGO:00430863350.053
lipid metabolic processGO:00066293810.052
positive regulation of cellular amino acid metabolic processGO:004576430.052
organophosphate catabolic processGO:00464344300.052
response to organic cyclic compoundGO:00140702040.051
growthGO:00400072020.050
regulation of cellular ketone metabolic processGO:0010565500.050
response to abiotic stimulusGO:00096283360.049
response to hormoneGO:00097251750.049
embryo development ending in birth or egg hatchingGO:0009792340.047
Worm
purine ribonucleoside triphosphate catabolic processGO:00092073910.047
response to inorganic substanceGO:00100351270.047
meiotic cell cycleGO:0051321130.046
anatomical structure homeostasisGO:00602491000.046
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.045
nucleoside catabolic processGO:00091644080.044
negative regulation of cell deathGO:00605483450.044
dna integrity checkpointGO:0031570710.044
Fly
ribosome assemblyGO:004225590.043
oocyte differentiationGO:000999420.042
purine nucleoside catabolic processGO:00061523980.041
rna processingGO:00063962550.041
protein modification by small protein conjugationGO:00324463420.040
cell type specific apoptotic processGO:00972851250.040
behaviorGO:00076101120.040
cytokinesis completion of separationGO:000710930.040
cellular response to endogenous stimulusGO:00714953360.040
cellular macromolecular complex assemblyGO:00346223240.040
response to ionizing radiationGO:0010212650.039
maintenance of locationGO:00512351120.039
regulation of meiosisGO:004002030.038
mrna catabolic processGO:0006402560.038
intracellular protein transportGO:00068862700.037
cellular component disassemblyGO:0022411920.037
peptidyl serine phosphorylationGO:00181051010.037
spindle organizationGO:0007051530.036
positive regulation of protein transportGO:00512221350.035
dna double strand break processingGO:0000729100.034
cell developmentGO:00484683280.034
cellular amine metabolic processGO:0044106410.034
negative regulation of protein modification processGO:00314002000.033
secretionGO:00469032540.033
negative regulation of cellular component organizationGO:00511292350.033
positive regulation of dna metabolic processGO:0051054730.033
Worm
regulation of protein catabolic processGO:00421761550.031
telomere maintenanceGO:0000723320.031
cellular response to ionizing radiationGO:0071479320.030
posttranscriptional regulation of gene expressionGO:00106082130.030
positive regulation of phosphorylationGO:00423273940.030
dephosphorylationGO:00163112090.030
regulation of anatomical structure morphogenesisGO:00226032860.030
peptidyl serine modificationGO:00182091060.030
regulation of dna replicationGO:0006275680.030
Worm
single organism reproductive processGO:0044702980.029
regulation of cell differentiationGO:00455953930.028
regulation of cellular amino acid metabolic processGO:000652160.028
negative regulation of organelle organizationGO:00106391260.028
gene loopingGO:009020210.027
chromatin remodelingGO:0006338550.027
mrna metabolic processGO:00160711750.026
neuron developmentGO:00486661130.026
cell cycle phase transitionGO:00447701730.026
Fly
negative regulation of developmental processGO:00510932470.026
negative regulation of phosphate metabolic processGO:00459362670.026
oogenesisGO:004847720.026
regulation of intracellular protein transportGO:00331571230.025
sex differentiationGO:0007548450.025
positive regulation of developmental processGO:00510943140.025
regulation of dephosphorylationGO:0035303960.025
negative regulation of dephosphorylationGO:0035305630.025
gene silencingGO:0016458490.024
cellular response to cytokine stimulusGO:00713451810.024
cellular ketone metabolic processGO:0042180800.024
nuclear transcribed mrna catabolic processGO:0000956480.024
regulation of kinase activityGO:00435493140.024
cell divisionGO:00513011680.023
lymphocyte activationGO:00466491330.023
response to radiationGO:00093141510.023
microtubule organizing center organizationGO:0031023620.023
meiotic cell cycle processGO:190304680.023
regulation of phosphatase activityGO:0010921810.023
g2 m transition of mitotic cell cycleGO:0000086410.023
Fly
cell activationGO:00017752130.022
regulation of protein kinase activityGO:00458592890.022
protein localization to organelleGO:00333652800.022
regulation of mitosisGO:0007088630.022
mrna processingGO:00063971330.022
endocytosisGO:00068971590.021
response to oxidative stressGO:00069791210.021
rna catabolic processGO:0006401710.021
agingGO:0007568660.021
regulation of g2 m transition of mitotic cell cycleGO:0010389200.021
Fly
microtubule cytoskeleton organizationGO:00002261760.021
reproductive system developmentGO:0061458560.020
neurogenesisGO:00220081690.020
generation of neuronsGO:00486991520.019
positive regulation of response to dna damage stimulusGO:2001022430.019
isotype switchingGO:004519030.019
sex determinationGO:000753030.019
mature ribosome assemblyGO:004225650.019
regulation of protein modification by small protein conjugation or removalGO:19033201070.019
protein oligomerizationGO:00512591730.019
oocyte developmentGO:004859910.019
nuclear transportGO:00511691790.018
nucleic acid phosphodiester bond hydrolysisGO:00903051020.018
regulation of cellular amine metabolic processGO:0033238110.018
single organism cellular localizationGO:19025803320.018
system processGO:00030083490.018
organelle assemblyGO:00709251760.018
ubiquitin dependent protein catabolic processGO:00065112060.017
chromosome separationGO:0051304230.017
positive regulation of protein phosphorylationGO:00019343130.017
leukocyte activationGO:00453211640.017
response to oxygen containing compoundGO:19017003690.017
reproductionGO:0000003630.017
Worm
central nervous system developmentGO:00074171230.017
positive regulation of histone methylationGO:0031062120.016
regulation of protein localization to nucleusGO:1900180850.016
negative regulation of protein metabolic processGO:00512483910.016
negative regulation of dna replicationGO:0008156290.016
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.016
multicellular organismal agingGO:001025930.016
positive regulation of cellular component organizationGO:00511303760.016
positive regulation of kinase activityGO:00336742040.016
nucleotide excision repairGO:0006289310.016
regulation of transferase activityGO:00513383550.016
gonad developmentGO:0008406340.016
regulation of growthGO:00400081650.016
response to uvGO:0009411730.016
regulation of gene expression epigeneticGO:0040029730.016
regulation of chromosome organizationGO:00330441030.016
cellular response to oxygen containing compoundGO:19017012760.016
positive regulation of cellular component biogenesisGO:00440891580.015
regulation of chromosome segregationGO:0051983440.015
skeletal system developmentGO:0001501790.015
chordate embryonic developmentGO:0043009340.015
polynucleotide dephosphorylationGO:009850130.015
development of primary sexual characteristicsGO:0045137350.015
regulation of microtubule polymerization or depolymerizationGO:0031110270.015
protein maturationGO:00516042330.014
nuclear importGO:00511701060.014
chemical homeostasisGO:00488783060.014
negative regulation of hydrolase activityGO:00513461820.014
response to organonitrogen compoundGO:00102431560.014
neuron projection developmentGO:00311751060.014
positive regulation of intracellular protein transportGO:0090316760.013
blood vessel morphogenesisGO:00485141620.013
metaphase plate congressionGO:0051310180.013
regulation of proteolysisGO:00301622930.013
negative regulation of intracellular signal transductionGO:19025321830.013
positive regulation of growthGO:0045927580.013
dna packagingGO:0006323770.013
positive regulation of organelle organizationGO:00106381950.013
signal transduction by p53 class mediatorGO:0072331720.012
single organism carbohydrate metabolic processGO:00447231930.012
developmental process involved in reproductionGO:0003006660.012
mitotic recombinationGO:000631280.012
sister chromatid segregationGO:0000819540.012
multicellular organism reproductionGO:0032504420.012
regulation of viral processGO:00507921030.012
non recombinational repairGO:0000726140.012
protein targetingGO:00066051870.012
cardiovascular system developmentGO:00723582620.012
cell part morphogenesisGO:00329901370.012
cell morphogenesisGO:00009022960.012
reciprocal meiotic recombinationGO:000713140.012
single organism nuclear importGO:19025931040.012
cytoplasmic transportGO:00164823790.012
protein catabolic processGO:00301633250.012
immune system developmentGO:00025201950.012
regulation of nucleocytoplasmic transportGO:0046822980.011
regulation of establishment of protein localizationGO:00702012420.011
regulation of dendritic cell chemotaxisGO:200050840.011
cellular carbohydrate metabolic processGO:0044262840.011
covalent chromatin modificationGO:00165692540.011
somatic recombination of immunoglobulin gene segmentsGO:001644740.011
rna interferenceGO:001624640.011
anatomical structure formation involved in morphogenesisGO:00486462840.011
somatic diversification of immunoglobulins involved in immune responseGO:000220830.011
leukocyte mediated immunityGO:0002443590.011
snrna modificationGO:004003110.011
protein localization to microtubule cytoskeletonGO:0072698100.011
cerebellum developmentGO:002154920.011
stem cell differentiationGO:0048863930.011
protein complex disassemblyGO:0043241520.011
microtubule depolymerizationGO:0007019180.011
negative regulation of cell cycle g2 m phase transitionGO:1902750100.011
Fly
dna hypermethylationGO:004402610.010
spermatid developmentGO:000728640.010
protein ubiquitinationGO:00165673140.010
mitotic spindle organizationGO:0007052270.010
cellular component morphogenesisGO:00329893140.010
regulation of chromatin assemblyGO:001084720.010

TOPBP1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
organ system cancerDOID:00506861640.053
cancerDOID:1621670.053
disease of cellular proliferationDOID:145661740.053