Homo sapiens

4 known processes

TRPM6

transient receptor potential cation channel, subfamily M, member 6

(Aliases: CHAK2,HOMG1,HSH,HOMG,HMGX)

TRPM6 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
actin filament based movementGO:0030048170.139
neurological system processGO:00508771630.095
Human
system processGO:00030083490.089
Human
transmembrane transportGO:00550853990.087
Human
cation transportGO:00068123310.081
Human
inorganic ion transmembrane transportGO:00986602310.073
Human
striated muscle contractionGO:0006941520.073
purine ribonucleoside metabolic processGO:00461284370.071
protein oligomerizationGO:00512591730.068
cellular amino acid metabolic processGO:00065201160.068
muscle contractionGO:0006936730.065
action potentialGO:0001508340.065
midgut developmentGO:000749410.064
purine containing compound catabolic processGO:00725234110.063
sensory perceptionGO:00076001030.062
Human
regulation of cell cycleGO:00517263930.062
cell adhesionGO:00071553250.062
post embryonic developmentGO:000979120.061
elastic fiber assemblyGO:004825130.061
transmission of nerve impulseGO:0019226110.059
nucleoside monophosphate metabolic processGO:00091231910.057
regulation of cellular amino acid metabolic processGO:000652160.057
amine metabolic processGO:0009308440.056
single organism cell adhesionGO:00986021790.056
nucleoside triphosphate metabolic processGO:00091414220.056
biological adhesionGO:00226103310.056
nucleoside phosphate catabolic processGO:19012924120.054
nucleotide catabolic processGO:00091664080.054
cellular amine metabolic processGO:0044106410.054
multicellular organismal signalingGO:0035637340.053
purine ribonucleotide catabolic processGO:00091544040.052
organophosphate catabolic processGO:00464344300.051
cellular ketone metabolic processGO:0042180800.051
cuticle developmentGO:004233510.050
purine nucleotide catabolic processGO:00061954050.050
regulation of ion transportGO:00432691890.049
myeloid cell differentiationGO:00300991170.049
purine nucleoside triphosphate catabolic processGO:00091463920.047
purine ribonucleoside catabolic processGO:00461303980.047
nucleoside catabolic processGO:00091644080.047
skeletal muscle contractionGO:0003009160.047
mitotic cell cycleGO:00002783260.047
ion transmembrane transportGO:00342203380.046
Human
regulation of membrane potentialGO:0042391950.046
glycosyl compound catabolic processGO:19016584130.046
inorganic cation transmembrane transportGO:00986621940.046
Human
salivary gland morphogenesisGO:000743540.045
ribonucleotide catabolic processGO:00092614050.045
ion homeostasisGO:00508012300.045
Human
positive regulation of cellular amino acid metabolic processGO:004576430.044
purine nucleoside triphosphate metabolic processGO:00091444120.044
regulation of cellular ketone metabolic processGO:0010565500.044
purine nucleoside monophosphate catabolic processGO:00091281580.044
vocalization behaviorGO:0071625110.044
ribonucleoside triphosphate metabolic processGO:00091994120.044
purine nucleoside monophosphate metabolic processGO:00091261860.043
cation transmembrane transportGO:00986552380.043
Human
purine ribonucleoside triphosphate catabolic processGO:00092073910.043
ribonucleoside triphosphate catabolic processGO:00092033910.042
positive regulation of cell proliferationGO:00082843010.042
Human
muscle system processGO:0003012810.042
metal ion transportGO:00300012720.041
Human
purine nucleoside catabolic processGO:00061523980.041
platelet formationGO:003022040.041
chemical homeostasisGO:00488783060.040
Human
regulation of cellular amine metabolic processGO:0033238110.040
determination of adult lifespanGO:000834020.039
immune system developmentGO:00025201950.039
purine ribonucleoside monophosphate metabolic processGO:00091671860.039
mitotic cell cycle processGO:19030472860.039
actin filament based processGO:00300292240.039
hematopoietic or lymphoid organ developmentGO:00485341860.038
ribonucleoside monophosphate metabolic processGO:00091611870.038
cellular macromolecular complex assemblyGO:00346223240.037
nucleoside monophosphate catabolic processGO:00091251590.037
membrane protein proteolysisGO:0033619380.037
lipid metabolic processGO:00066293810.036
myosin filament assemblyGO:003103420.035
positive regulation of cellular amine metabolic processGO:003324070.035
immune responseGO:00069553070.035
Human
maintenance of locationGO:00512351120.035
cellular protein complex assemblyGO:00436231880.035
mitochondrion organizationGO:00070051560.035
metal ion homeostasisGO:00550651690.035
Human
multicellular organismal agingGO:001025930.035
ribonucleoside monophosphate catabolic processGO:00091581580.034
regulation of secretion by cellGO:19035301770.034
leukocyte differentiationGO:0002521980.033
anatomical structure formation involved in morphogenesisGO:00486462840.033
positive regulation of phosphorylationGO:00423273940.033
female gamete generationGO:000729220.033
locomotory behaviorGO:000762610.033
nervous system developmentGO:00073992930.033
sensory perception of soundGO:0007605370.032
atp metabolic processGO:00460341760.032
blood vessel developmentGO:00015681720.032
angiogenesisGO:00015251470.032
positive regulation of transportGO:00510503360.032
regulation of secretionGO:00510461940.032
atp catabolic processGO:00062001570.032
secretion by cellGO:00329402260.031
cellular lipid metabolic processGO:00442553030.031
purine ribonucleoside triphosphate metabolic processGO:00092054110.030
response to other organismGO:00517072610.030
negative regulation of transportGO:00510511760.030
circulatory system developmentGO:00723592620.030
secretionGO:00469032540.030
regulation of transferase activityGO:00513383550.030
multicellular organismal movementGO:0050879170.030
cell divisionGO:00513011680.030
actin cytoskeleton organizationGO:00300362070.029
oogenesisGO:004847720.029
response to external biotic stimulusGO:00432072610.029
regulation of anatomical structure morphogenesisGO:00226032860.029
cell developmentGO:00484683280.029
negative regulation of cell proliferationGO:00082852280.029
negative regulation of protein metabolic processGO:00512483910.029
myosin filament organizationGO:003103320.028
regulation of establishment of protein localizationGO:00702012420.028
regulation of protein localizationGO:00328802960.028
neuromuscular junction developmentGO:000752830.028
small molecule biosynthetic processGO:00442831570.028
myeloid leukocyte differentiationGO:0002573600.027
cellular response to oxygen containing compoundGO:19017012760.027
organ morphogenesisGO:00098871470.027
cellular homeostasisGO:00197251960.027
Human
cardiovascular system developmentGO:00723582620.027
response to biotic stimulusGO:00096072760.027
divalent inorganic cation homeostasisGO:00725071360.027
Human
mapk cascadeGO:00001652880.026
regulation of mapk cascadeGO:00434082620.026
regulation of protein transportGO:00512232130.026
positive regulation of hydrolase activityGO:00513453310.026
blood vessel morphogenesisGO:00485141620.026
regulation of transmembrane transportGO:00347621390.025
epithelium migrationGO:00901321190.025
cation homeostasisGO:00550801890.025
Human
single organism membrane organizationGO:00448022680.025
cellular ion homeostasisGO:00068731680.025
Human
nucleoside triphosphate catabolic processGO:00091433940.025
cytokinesisGO:0000910960.025
cardiac muscle cell contractionGO:008600340.025
vasculature developmentGO:00019441810.025
protein maturationGO:00516042330.024
positive regulation of cellular component organizationGO:00511303760.024
response to oxygen containing compoundGO:19017003690.024
regulation of kinase activityGO:00435493140.024
cell morphogenesisGO:00009022960.024
negative regulation of cell deathGO:00605483450.024
membrane organizationGO:00610242920.024
calcium ion homeostasisGO:00550741220.024
Human
innate immune responseGO:00450871780.023
signal transduction by phosphorylationGO:00230142970.023
carbohydrate metabolic processGO:00059752070.023
ribonucleoside catabolic processGO:00424544060.023
hemostasisGO:0007599760.023
behaviorGO:00076101120.023
positive regulation of protein kinase activityGO:00458601900.023
organelle assemblyGO:00709251760.023
cellular metal ion homeostasisGO:00068751460.023
Human
defense responseGO:00069523150.023
segmentationGO:003528240.023
single organism cellular localizationGO:19025803320.023
cellular component morphogenesisGO:00329893140.023
negative regulation of cellular protein metabolic processGO:00322693530.023
regulation of cell cycle processGO:00105642660.023
regulation of protein kinase activityGO:00458592890.022
anion transportGO:00068201610.022
ameboidal type cell migrationGO:00016671350.022
actin mediated cell contractionGO:0070252120.022
protein localization to organelleGO:00333652800.022
positive regulation of mapk cascadeGO:00434101900.022
musculoskeletal movementGO:0050881170.022
positive regulation of immune system processGO:00026842830.022
regulation of cytokine productionGO:00018172320.022
Human
positive regulation of cellular catabolic processGO:00313312840.022
negative regulation of catalytic activityGO:00430863350.022
positive regulation of apoptotic processGO:00430652460.022
intracellular protein transportGO:00068862700.022
positive regulation of protein phosphorylationGO:00019343130.022
cytoplasmic transportGO:00164823790.022
Human
regulation of proteolysisGO:00301622930.022
memoryGO:000761330.021
epithelial cell migrationGO:00106311190.021
maintenance of location in cellGO:0051651620.021
monocarboxylic acid metabolic processGO:00327871850.021
nitrogen compound transportGO:00717051910.021
positive regulation of transferase activityGO:00513472270.021
cellular response to dna damage stimulusGO:00069743790.021
response to abiotic stimulusGO:00096283360.021
Human
sensory perception of mechanical stimulusGO:0050954370.021
vesicle mediated transportGO:00161923710.021
positive regulation of cell deathGO:00109422630.021
small gtpase mediated signal transductionGO:0007264780.021
positive regulation of catabolic processGO:00098963100.020
regulation of cell morphogenesisGO:00226041530.020
ras protein signal transductionGO:0007265730.020
blastoderm segmentationGO:000735020.020
protein catabolic processGO:00301633250.020
platelet morphogenesisGO:003634440.020
anterior posterior axis specificationGO:000994820.020
cellular calcium ion homeostasisGO:00068741170.020
Human
cellular cation homeostasisGO:00300031630.020
Human
protein processingGO:00164852260.020
negative regulation of programmed cell deathGO:00430693210.020
tissue migrationGO:00901301190.020
regulation of cellular component biogenesisGO:00440872810.019
platelet aggregationGO:0070527320.019
regulation of ion transmembrane transportGO:00347651320.019
maintenance of protein locationGO:0045185570.019
cellular chemical homeostasisGO:00550821800.019
Human
coagulationGO:0050817780.019
regenerationGO:003109940.019
cellular macromolecule catabolic processGO:00442653800.019
regulation of protein serine threonine kinase activityGO:00719001790.019
cellular divalent inorganic cation homeostasisGO:00725031280.019
Human
regulation of cell motilityGO:20001452990.019
associative learningGO:000830610.019
lipid biosynthetic processGO:00086101770.019
rhythmic behaviorGO:000762220.019
membrane protein ectodomain proteolysisGO:0006509330.019
monovalent inorganic cation transportGO:00156721280.018
negative regulation of phosphorus metabolic processGO:00105632670.018
regulation of nucleotide metabolic processGO:00061402690.018
positive regulation of programmed cell deathGO:00430682490.018
hemopoiesisGO:00300971800.018
positive regulation of developmental processGO:00510943140.018
reactive nitrogen species metabolic processGO:200105730.018
g protein coupled receptor signaling pathwayGO:00071862070.018
Human
nuclear transportGO:00511691790.018
dephosphorylationGO:00163112090.018
response to cytokineGO:00340972320.018
single organism carbohydrate metabolic processGO:00447231930.018
guanosine containing compound metabolic processGO:19010682440.018
regulation of purine nucleotide metabolic processGO:19005422640.018
homotypic cell cell adhesionGO:0034109470.018
regulation of cellular component movementGO:00512703340.017
organonitrogen compound biosynthetic processGO:19015662000.017
cytokine productionGO:00018162470.017
Human
spermatid differentiationGO:004851540.017
cellular potassium ion transportGO:0071804600.017
negative regulation of cellular amino acid metabolic processGO:004576320.017
oxidation reduction processGO:00551143960.017
reactive oxygen species biosynthetic processGO:190340940.017
negative regulation of phosphate metabolic processGO:00459362670.017
cellular protein catabolic processGO:00442572610.017
carbohydrate derivative biosynthetic processGO:19011372070.017
negative regulation of cellular amine metabolic processGO:003323930.017
leukocyte activationGO:00453211640.017
regulation of metal ion transportGO:00109591200.017
regulation of endopeptidase activityGO:00525481700.017
negative regulation of multicellular organismal processGO:00512413170.017
regulation of peptidase activityGO:00525471800.017
circadian behaviorGO:004851220.016
negative regulation of cellular component organizationGO:00511292350.016
organic acid biosynthetic processGO:0016053970.016
regulation of response to external stimulusGO:00321012220.016
regulation of body fluid levelsGO:0050878990.016
response to woundingGO:00096111680.016
regulation of intracellular transportGO:00323861950.016
regulation of cell differentiationGO:00455953930.016
negative regulation of apoptotic processGO:00430663160.016
regulation of cellular response to stressGO:00801352440.016
neurogenesisGO:00220081690.016
positive regulation of protein transportGO:00512221350.016
regulation of nucleoside metabolic processGO:00091182090.016
negative regulation of cell cycleGO:00457861930.016
spermatid developmentGO:000728640.016
cellular component assembly involved in morphogenesisGO:0010927730.016
oocyte differentiationGO:000999420.016
apoptotic signaling pathwayGO:00971902680.016
regulation of cytoplasmic transportGO:19036491490.016
regulation of sequence specific dna binding transcription factor activityGO:00510902110.016
matingGO:000761810.016
positive regulation of secretion by cellGO:19035321080.016
negative regulation of cell differentiationGO:00455961710.016
positive regulation of kinase activityGO:00336742040.016
regulation of reactive oxygen species biosynthetic processGO:190342630.016
protein targetingGO:00066051870.015
positive regulation of reactive oxygen species biosynthetic processGO:190342820.015
positive regulation of cell differentiationGO:00455972110.015
oocyte developmentGO:004859910.015
response to bacteriumGO:00096171440.015
guanosine containing compound catabolic processGO:19010692390.015
response to organic cyclic compoundGO:00140702040.015
epithelial cell proliferationGO:00506731280.015
cellular response to cytokine stimulusGO:00713451810.015
postsynaptic membrane organizationGO:000194120.015
endothelial cell migrationGO:0043542860.015
positive regulation of nucleotide metabolic processGO:00459812300.015
protein secretionGO:0009306980.015
cellular response to endogenous stimulusGO:00714953360.015
inorganic anion transmembrane transportGO:0098661470.015
positive regulation of gtp catabolic processGO:00331261660.015
blood coagulationGO:0007596760.015
negative regulation of protein modification processGO:00314002000.015
positive regulation of cytokine productionGO:00018191670.015
negative regulation of intracellular signal transductionGO:19025321830.015
cell projection organizationGO:00300302520.015
response to virusGO:00096151260.014
regulation of immune responseGO:00507762010.014
Human
carboxylic acid biosynthetic processGO:0046394970.014
gtp metabolic processGO:00460392390.014
protein modification by small protein conjugationGO:00324463420.014
Human
proteolysis involved in cellular protein catabolic processGO:00516032440.014
growthGO:00400072020.014
posttranscriptional regulation of gene expressionGO:00106082130.014
left right pattern formationGO:006097220.014
regulation of purine nucleotide catabolic processGO:00331212050.014
regulation of transmembrane transporter activityGO:0022898740.014
hindbrain developmentGO:003090230.014
wound healingGO:00420601150.014
cell activationGO:00017752130.014
rho protein signal transductionGO:0007266260.014
adult locomotory behaviorGO:000834410.014
positive regulation of nucleoside metabolic processGO:00459791860.014
peptidyl tyrosine phosphorylationGO:00181081700.014
positive regulation of cellular component biogenesisGO:00440891580.014
protein ubiquitinationGO:00165673140.014
positive regulation of immune responseGO:00507781590.014
establishment of protein localization to organelleGO:00725941720.014
nucleocytoplasmic transportGO:00069131760.014
cell cycle phase transitionGO:00447701730.014
cell growthGO:00160491600.014
response to lipidGO:00339932060.014
regulation of ion transmembrane transporter activityGO:0032412720.014
regulation of protein secretionGO:0050708860.014
positive regulation of gtpase activityGO:00435471660.014
chromatin organizationGO:00063253510.014
regulation of protein catabolic processGO:00421761550.014
regulation of map kinase activityGO:00434051080.014
regulation of gtpase activityGO:00430871800.014
positive regulation of purine nucleotide catabolic processGO:00331231850.014
response to nitrogen compoundGO:19016981840.014
regulation of cell divisionGO:00513021160.014
regulation of meiotic cell cycleGO:005144540.013
positive regulation of cell cycleGO:00457871400.013
peptidyl tyrosine modificationGO:00182121700.013
cellular response to histamineGO:007142030.013
maintenance of protein location in cellGO:0032507560.013
metencephalon developmentGO:002203720.013
cytokine mediated signaling pathwayGO:00192211090.013
gtp catabolic processGO:00061842370.013
startle responseGO:000196430.013
actomyosin structure organizationGO:0031032590.013
positive regulation of proteolysisGO:00458621420.013
regulation of i kappab kinase nf kappab signalingGO:00431221620.013
sensory perception of painGO:001923340.013
photoreceptor cell differentiationGO:004653020.013
divalent inorganic cation transportGO:00725111580.013
Human
negative regulation of secretionGO:0051048580.013
chromatin modificationGO:00165682980.013
peripheral nervous system developmentGO:000742220.013
regulation of intracellular protein transportGO:00331571230.013
chloride transportGO:0006821410.013
modification dependent macromolecule catabolic processGO:00436322120.013
regulation of feeding behaviorGO:006025930.013
syncytium formation by plasma membrane fusionGO:000076820.013
regulation of nucleotide catabolic processGO:00308112050.013
modification dependent protein catabolic processGO:00199412090.013
tripartite regional subdivisionGO:000735120.013
divalent metal ion transportGO:00708381520.013
Human
cellular response to lipidGO:00713961270.013
reactive oxygen species metabolic processGO:0072593750.013
organophosphate biosynthetic processGO:00904071630.013
cell part morphogenesisGO:00329901370.013
regulation of mitotic cell cycleGO:00073461890.013
anterior posterior axis specification embryoGO:000859520.013
regulation of cytoskeleton organizationGO:00514931770.013
immune response regulating signaling pathwayGO:0002764970.013
potassium ion transportGO:0006813620.013
positive regulation of purine nucleotide metabolic processGO:19005442270.013
protein homooligomerizationGO:00512601000.013
protein localization to membraneGO:00726571600.013
positive regulation of organelle organizationGO:00106381950.013
visual behaviorGO:000763220.013
inner ear morphogenesisGO:004247240.013
regulation of ras protein signal transductionGO:00465781550.013
single organismal cell cell adhesionGO:00163371480.013
negative regulation of hydrolase activityGO:00513461820.013
mitotic cell cycle phase transitionGO:00447721620.013
regulation of transporter activityGO:0032409820.012
regulation of multi organism processGO:00439001570.012
neuroblast proliferationGO:000740540.012
symbiosis encompassing mutualism through parasitismGO:00444031560.012
proteasomal protein catabolic processGO:00104981760.012
nerve developmentGO:002167540.012
lipid localizationGO:00108761060.012
regulation of apoptotic signaling pathwayGO:20012331750.012
activation of immune responseGO:00022531140.012
histone modificationGO:00165702510.012
sequestering of metal ionGO:0051238240.012
negative regulation of phosphorylationGO:00423261740.012
glial cell migrationGO:000834740.012
potassium ion transmembrane transportGO:0071805600.012
actin filament organizationGO:00070151280.012
cellular response to organonitrogen compoundGO:00714171240.012
extracellular matrix organizationGO:0030198410.012
calcium ion transportGO:00068161470.012
Human
regulation of actin filament based processGO:00329701410.012
lipid transportGO:0006869900.012
regulation of cell growthGO:00015581350.012
microtubule based processGO:00070172100.012
positive regulation of protein serine threonine kinase activityGO:00719021190.012
positive regulation of ion transportGO:0043270870.012
positive regulation of cell cycle processGO:00900681060.012
cardiac muscle contractionGO:0060048340.012
microtubule cytoskeleton organizationGO:00002261760.012
positive regulation of secretionGO:00510471160.012
muscle cell differentiationGO:0042692630.012
cytokine secretionGO:0050663640.012
inorganic anion transportGO:0015698600.012
sequestering of calcium ionGO:0051208170.012
motor neuron axon guidanceGO:000804520.012
positive regulation of nucleotide catabolic processGO:00308131850.012
ubiquitin dependent protein catabolic processGO:00065112060.012
negative regulation of developmental processGO:00510932470.012
fatty acid metabolic processGO:00066311150.012
sex determinationGO:000753030.012
organic hydroxy compound metabolic processGO:19016151470.012
regulation of small gtpase mediated signal transductionGO:00510561560.012
endomembrane system organizationGO:00102561960.011
compound eye developmentGO:004874910.011
rna processingGO:00063962550.011
cerebellum developmentGO:002154920.011
negative regulation of protein transportGO:0051224750.011
multi organism cellular processGO:00447641560.011
chloride transmembrane transportGO:1902476380.011
anion transmembrane transportGO:0098656760.011
cell fate determinationGO:000170930.011
cardiac muscle fiber developmentGO:004873940.011
platelet activationGO:0030168440.011
sulfur compound metabolic processGO:00067901010.011
immune effector processGO:00022521590.011
Human
positive regulation of cellular component movementGO:00512721810.011
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.011
response to fungusGO:000962040.011
positive regulation of synaptic transmissionGO:005080640.011
digestive tract developmentGO:0048565750.011
negative regulation of cytokine productionGO:0001818820.011
regulation of homeostatic processGO:00328441210.011
positive regulation of cell migrationGO:00303351720.011
release of cytoplasmic sequestered nf kappabGO:000858840.011
angiotensin activated signaling pathwayGO:003816640.011
regulation of gtp catabolic processGO:00331241800.011
regulation of protein complex assemblyGO:00432541470.011
regulation of meiosisGO:004002030.011
nucleus localizationGO:005164710.011
regulation of ras gtpase activityGO:00323181280.011
regulation of actin cytoskeleton organizationGO:00329561160.011
response to organonitrogen compoundGO:00102431560.011
regulation of reactive oxygen species metabolic processGO:2000377410.011
meiosis iGO:000712740.011
methylationGO:00322591060.011
limbic system developmentGO:002176130.011
negative regulation of secretion by cellGO:1903531520.011
regulation of cysteine type endopeptidase activityGO:20001161270.011
morphogenesis of a polarized epitheliumGO:000173830.011
response to axon injuryGO:004867810.011
i kappab kinase nf kappab signalingGO:00072491660.011
regulation of protein maturationGO:19033171500.011
interspecies interaction between organismsGO:00444191560.011
positive regulation of reactive oxygen species metabolic processGO:2000379240.011
mrna metabolic processGO:00160711750.011
regulation of phosphatase activityGO:0010921810.011
second messenger mediated signalingGO:0019932780.011
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.010
protein importGO:00170381300.010
alcohol metabolic processGO:00060661140.010
ossificationGO:00015031210.010
regulation of cell shapeGO:0008360480.010
negative regulation of transmission of nerve impulseGO:005197010.010
negative regulation of immune system processGO:00026831360.010
regulation of growthGO:00400081650.010

TRPM6 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.168
Human
sensory system diseaseDOID:00501552030.168
Human
nonsyndromic deafnessDOID:0050563500.074
auditory system diseaseDOID:2742530.074
autosomal dominant nonsyndromic deafnessDOID:0050564230.030
disease of metabolismDOID:00146672950.025
eye and adnexa diseaseDOID:14921500.024
Human
eye diseaseDOID:56141490.022
Human
inherited metabolic disorderDOID:6552420.019
retinal diseaseDOID:56791180.018
Human
central nervous system diseaseDOID:3311860.018
musculoskeletal system diseaseDOID:172230.016
organ system cancerDOID:00506861640.016
disease of cellular proliferationDOID:145661740.016
cancerDOID:1621670.016
retinal degenerationDOID:8466890.013
connective tissue diseaseDOID:651090.013
immune system diseaseDOID:29141550.012
neurodegenerative diseaseDOID:12891020.011