Homo sapiens

33 known processes

HERC2

hect domain and RLD 2

(Aliases: SHEP1,DKFZp547P028,p528,KIAA0393,jdf2,D15F37S1)

HERC2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
histone h2b conserved c terminal lysine deubiquitinationGO:003561610.728
protein deubiquitinationGO:0016579790.658
histone deubiquitinationGO:0016578160.548
protein modification by small protein conjugationGO:00324463420.406
histone modificationGO:00165702510.358
protein ubiquitinationGO:00165673140.313
proteolysis involved in cellular protein catabolic processGO:00516032440.309
cellular macromolecule catabolic processGO:00442653800.236
cellular protein catabolic processGO:00442572610.211
ubiquitin dependent protein catabolic processGO:00065112060.210
modification dependent protein catabolic processGO:00199412090.198
protein catabolic processGO:00301633250.189
chromatin modificationGO:00165682980.186
chromatin organizationGO:00063253510.167
regulation of protein ubiquitinationGO:0031396950.159
cellular response to dna damage stimulusGO:00069743790.158
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.155
regulation of cell cycleGO:00517263930.153
modification dependent macromolecule catabolic processGO:00436322120.149
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.125
negative regulation of protein metabolic processGO:00512483910.121
cell cycle checkpointGO:00000751170.117
rna processingGO:00063962550.114
regulation of protein catabolic processGO:00421761550.109
dna repairGO:00062811980.099
regulation of cell cycle processGO:00105642660.098
metaphase anaphase transition of cell cycleGO:0044784210.097
negative regulation of protein processingGO:00109551420.095
regulation of protein modification by small protein conjugation or removalGO:19033201070.092
negative regulation of cell cycle processGO:00109481210.091
mitotic cell cycle processGO:19030472860.090
cellular amino acid metabolic processGO:00065201160.090
regulation of mitotic cell cycleGO:00073461890.089
amine metabolic processGO:0009308440.088
proteasomal protein catabolic processGO:00104981760.087
protein processingGO:00164852260.086
negative regulation of cell cycleGO:00457861930.086
cellular amine metabolic processGO:0044106410.086
regulation of transferase activityGO:00513383550.085
posttranscriptional regulation of gene expressionGO:00106082130.085
negative regulation of cellular protein metabolic processGO:00322693530.085
regulation of proteasomal protein catabolic processGO:0061136870.084
cell cycle phase transitionGO:00447701730.083
regulation of mitotic cell cycle phase transitionGO:19019901180.082
post embryonic developmentGO:000979120.081
mitotic cell cycleGO:00002783260.081
protein modification by small protein removalGO:0070646920.079
negative regulation of cell cycle phase transitionGO:1901988890.079
negative regulation of mitotic cell cycleGO:00459301020.077
regulation of cell cycle phase transitionGO:19019871260.076
positive regulation of catabolic processGO:00098963100.075
regulation of cellular protein catabolic processGO:1903362960.075
negative regulation of protein modification processGO:00314002000.073
regulation of cellular amino acid metabolic processGO:000652160.073
negative regulation of catalytic activityGO:00430863350.072
regulation of proteolysisGO:00301622930.072
mrna metabolic processGO:00160711750.071
regulation of protein stabilityGO:0031647870.069
protein maturationGO:00516042330.069
rna splicingGO:00083801310.068
regulation of wnt signaling pathwayGO:00301111230.067
covalent chromatin modificationGO:00165692540.065
negative regulation of mitotic cell cycle phase transitionGO:1901991850.064
regulation of cellular amine metabolic processGO:0033238110.064
regulation of cellular ketone metabolic processGO:0010565500.063
chromosome separationGO:0051304230.062
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic processGO:0031145250.062
negative regulation of protein maturationGO:19033181420.060
negative regulation of cellular component organizationGO:00511292350.059
negative regulation of catabolic processGO:00098951040.059
cellular ketone metabolic processGO:0042180800.057
regulation of protein processingGO:00706131500.056
regulation of sister chromatid segregationGO:0033045270.055
regulation of mitosisGO:0007088630.055
negative regulation of cellular catabolic processGO:0031330830.054
nervous system developmentGO:00073992930.054
negative regulation of proteolysisGO:00458611320.053
regulation of protein maturationGO:19033171500.052
ras protein signal transductionGO:0007265730.052
regulation of mitotic sister chromatid segregationGO:0033047270.052
cell divisionGO:00513011680.051
regulation of nuclear divisionGO:0051783650.051
negative regulation of protein ubiquitinationGO:0031397350.051
apoptotic signaling pathwayGO:00971902680.051
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.051
negative regulation of ubiquitin protein transferase activityGO:005144480.047
purine nucleoside triphosphate catabolic processGO:00091463920.047
mitotic nuclear divisionGO:00070671190.046
regulation of ligase activityGO:0051340290.046
regulation of mitotic metaphase anaphase transitionGO:0030071260.046
mitotic sister chromatid separationGO:0051306180.044
mitotic sister chromatid segregationGO:0000070530.044
negative regulation of chromosome organizationGO:2001251480.044
hindbrain developmentGO:003090230.043
locomotory behaviorGO:000762610.042
nuclear divisionGO:00002801280.041
female gamete generationGO:000729220.041
positive regulation of transportGO:00510503360.041
small gtpase mediated signal transductionGO:0007264780.040
regulation of metaphase anaphase transition of cell cycleGO:1902099260.040
organelle fissionGO:00482851490.040
negative regulation of mitotic metaphase anaphase transitionGO:0045841170.040
regulation of chromosome segregationGO:0051983440.039
nucleoside triphosphate metabolic processGO:00091414220.039
single organism cellular localizationGO:19025803320.039
protein localization to organelleGO:00333652800.039
negative regulation of organelle organizationGO:00106391260.038
oogenesisGO:004847720.038
metaphase anaphase transition of mitotic cell cycleGO:0007091210.038
rna splicing via transesterification reactionsGO:0000375900.038
organophosphate catabolic processGO:00464344300.037
ribonucleoside triphosphate catabolic processGO:00092033910.037
positive regulation of cellular amino acid metabolic processGO:004576430.037
cellular component morphogenesisGO:00329893140.036
response to abiotic stimulusGO:00096283360.036
ribonucleoside catabolic processGO:00424544060.036
purine ribonucleoside metabolic processGO:00461284370.036
sister chromatid segregationGO:0000819540.036
chromosome segregationGO:00070591140.035
cellular response to oxygen containing compoundGO:19017012760.034
negative regulation of protein modification by small protein conjugation or removalGO:1903321410.034
neuromuscular junction developmentGO:000752830.034
negative regulation of cellular protein catabolic processGO:1903363380.033
positive regulation of cellular amine metabolic processGO:003324070.033
purine ribonucleotide catabolic processGO:00091544040.033
microtubule cytoskeleton organizationGO:00002261760.033
cellular macromolecular complex assemblyGO:00346223240.033
regulation of protein localizationGO:00328802960.032
nucleotide catabolic processGO:00091664080.032
ribonucleoside triphosphate metabolic processGO:00091994120.032
negative regulation of protein catabolic processGO:0042177590.031
cell morphogenesisGO:00009022960.031
regulation of chromosome organizationGO:00330441030.031
nucleoside phosphate catabolic processGO:19012924120.031
regulation of cell divisionGO:00513021160.031
positive regulation of cellular component organizationGO:00511303760.031
purine ribonucleoside triphosphate catabolic processGO:00092073910.031
organelle assemblyGO:00709251760.031
cell projection organizationGO:00300302520.030
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377890.030
regulation of mitotic sister chromatid separationGO:0010965270.030
multicellular organismal agingGO:001025930.030
negative regulation of multicellular organismal processGO:00512413170.030
nucleoside catabolic processGO:00091644080.029
regulation of ubiquitin protein transferase activityGO:0051438280.029
negative regulation of programmed cell deathGO:00430693210.029
purine containing compound catabolic processGO:00725234110.029
negative regulation of transferase activityGO:00513481240.029
neuron projection developmentGO:00311751060.029
cell developmentGO:00484683280.028
regulation of cytoskeleton organizationGO:00514931770.028
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.028
system processGO:00030083490.028
purine nucleoside triphosphate metabolic processGO:00091444120.028
immune system developmentGO:00025201950.028
spindle checkpointGO:0031577260.028
regulation of nucleoside metabolic processGO:00091182090.028
purine nucleoside catabolic processGO:00061523980.028
glycosyl compound catabolic processGO:19016584130.028
positive regulation of cellular catabolic processGO:00313312840.027
purine ribonucleoside triphosphate metabolic processGO:00092054110.027
positive regulation of phosphorylationGO:00423273940.027
negative regulation of mitotic anaphase promoting complex activityGO:006056440.027
protein k63 linked deubiquitinationGO:0070536210.027
lipid metabolic processGO:00066293810.026
protein polyubiquitinationGO:00002091100.026
response to radiationGO:00093141510.026
cytoplasmic transportGO:00164823790.026
cerebellum developmentGO:002154920.026
negative regulation of proteasomal protein catabolic processGO:1901799320.025
nucleoside triphosphate catabolic processGO:00091433940.025
transmembrane transportGO:00550853990.025
protein localization to nucleusGO:00345041360.025
metencephalon developmentGO:002203720.024
positive regulation of developmental processGO:00510943140.024
negative regulation of sister chromatid segregationGO:0033046170.024
signal transduction by phosphorylationGO:00230142970.024
response to lipidGO:00339932060.024
mrna processingGO:00063971330.024
neural tube formationGO:000184130.024
protein acetylationGO:00064731160.023
negative regulation of ligase activityGO:005135280.023
regulation of anatomical structure morphogenesisGO:00226032860.023
protein targetingGO:00066051870.023
regulation of cell morphogenesisGO:00226041530.023
endomembrane system organizationGO:00102561960.023
positive regulation of nucleotide metabolic processGO:00459812300.023
guanosine containing compound catabolic processGO:19010692390.022
cellular response to endogenous stimulusGO:00714953360.022
purine nucleotide catabolic processGO:00061954050.022
regulation of gtpase activityGO:00430871800.022
determination of adult lifespanGO:000834020.022
protein acylationGO:00435431380.022
intracellular protein transportGO:00068862700.022
negative regulation of cellular amine metabolic processGO:003323930.022
protein k48 linked ubiquitinationGO:0070936380.022
extrinsic apoptotic signaling pathwayGO:00971911190.021
actin filament based processGO:00300292240.021
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051350.021
regulation of apoptotic signaling pathwayGO:20012331750.021
immune responseGO:00069553070.021
peptidyl lysine acetylationGO:00183941010.021
positive regulation of hydrolase activityGO:00513453310.021
neuron differentiationGO:00301821380.021
central nervous system developmentGO:00074171230.020
growthGO:00400072020.020
negative regulation of cell proliferationGO:00082852280.020
primary neural tube formationGO:001402030.020
negative regulation of cell deathGO:00605483450.020
secretionGO:00469032540.020
regulation of cellular response to stressGO:00801352440.020
oocyte differentiationGO:000999420.020
gtp catabolic processGO:00061842370.020
cell type specific apoptotic processGO:00972851250.020
peptidyl lysine modificationGO:00182051440.020
purine ribonucleoside catabolic processGO:00461303980.020
wnt signaling pathwayGO:00160551560.020
guanosine containing compound metabolic processGO:19010682440.019
microtubule based processGO:00070172100.019
positive regulation of transferase activityGO:00513472270.019
purine nucleoside monophosphate catabolic processGO:00091281580.019
negative regulation of mitosisGO:0045839240.019
ion homeostasisGO:00508012300.019
gtp metabolic processGO:00460392390.019
negative regulation of mitotic sister chromatid separationGO:2000816170.019
mapk cascadeGO:00001652880.019
response to oxygen containing compoundGO:19017003690.019
regulation of response to dna damage stimulusGO:2001020940.019
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycleGO:005143640.019
regulation of cellular component biogenesisGO:00440872810.019
compound eye developmentGO:004874910.018
negative regulation of metaphase anaphase transition of cell cycleGO:1902100170.018
cell morphogenesis involved in differentiationGO:00009041440.018
negative regulation of cell divisionGO:0051782310.018
response to other organismGO:00517072610.018
negative regulation of developmental processGO:00510932470.018
negative regulation of phosphorus metabolic processGO:00105632670.018
oxidation reduction processGO:00551143960.018
positive regulation of purine nucleotide catabolic processGO:00331231850.018
positive regulation of cellular component biogenesisGO:00440891580.018
generation of neuronsGO:00486991520.018
defense responseGO:00069523150.018
rho protein signal transductionGO:0007266260.018
cellular protein complex assemblyGO:00436231880.018
morphogenesis of embryonic epitheliumGO:001633140.017
cell growthGO:00160491600.017
cellular response to lipidGO:00713961270.017
positive regulation of immune system processGO:00026842830.017
meiosis iGO:000712740.017
establishment of protein localization to organelleGO:00725941720.017
mitotic cell cycle phase transitionGO:00447721620.017
regulation of establishment of protein localizationGO:00702012420.017
peptidyl serine phosphorylationGO:00181051010.017
cation transportGO:00068123310.017
maintenance of locationGO:00512351120.017
negative regulation of cellular amino acid metabolic processGO:004576320.017
cell part morphogenesisGO:00329901370.017
regulation of cytokine productionGO:00018172320.016
regulation of sequence specific dna binding transcription factor activityGO:00510902110.016
regulation of protein complex assemblyGO:00432541470.016
spermatid differentiationGO:004851540.016
response to external biotic stimulusGO:00432072610.016
histone h3 acetylationGO:0043966450.016
positive regulation of protein transportGO:00512221350.016
negative regulation of mitotic sister chromatid segregationGO:0033048170.016
anatomical structure formation involved in morphogenesisGO:00486462840.016
negative regulation of chromosome segregationGO:0051985180.016
positive regulation of protein phosphorylationGO:00019343130.016
positive regulation of purine nucleotide metabolic processGO:19005442270.016
purine ribonucleoside monophosphate catabolic processGO:00091691580.016
vesicle mediated transportGO:00161923710.016
negative regulation of apoptotic processGO:00430663160.016
peripheral nervous system developmentGO:000742220.016
regulation of intracellular transportGO:00323861950.016
response to organic cyclic compoundGO:00140702040.016
cellular homeostasisGO:00197251960.016
regenerationGO:003109940.015
regulation of secretionGO:00510461940.015
nuclear transportGO:00511691790.015
chemical homeostasisGO:00488783060.015
double strand break repairGO:00063021010.015
regulation of cell developmentGO:00602841610.015
meiotic chromosome segregationGO:004513240.015
positive regulation of nucleoside metabolic processGO:00459791860.015
epidermis morphogenesisGO:004873030.015
protein oligomerizationGO:00512591730.015
monovalent inorganic cation transportGO:00156721280.015
reactive oxygen species metabolic processGO:0072593750.015
innate immune responseGO:00450871780.015
cellular response to growth factor stimulusGO:00713631970.015
developmental programmed cell deathGO:001062330.015
regulation of dna metabolic processGO:00510521530.014
regulation of mapk cascadeGO:00434082620.014
negative regulation of intracellular signal transductionGO:19025321830.014
positive regulation of cell deathGO:00109422630.014
regulation of synaptic plasticityGO:004816730.014
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.014
ribonucleotide catabolic processGO:00092614050.014
negative regulation of hydrolase activityGO:00513461820.014
carbohydrate metabolic processGO:00059752070.014
negative regulation of phosphorylationGO:00423261740.014
regulation of protein transportGO:00512232130.014
prostate gland developmentGO:003085030.014
regulation of gtp catabolic processGO:00331241800.014
ribonucleoside monophosphate catabolic processGO:00091581580.014
epithelium developmentGO:00604292270.014
dephosphorylationGO:00163112090.014
membrane organizationGO:00610242920.014
atp metabolic processGO:00460341760.014
regulation of response to external stimulusGO:00321012220.014
positive regulation of gtpase activityGO:00435471660.014
positive regulation of protein catabolic processGO:0045732750.014
positive regulation of organelle organizationGO:00106381950.014
cell projection morphogenesisGO:00488581290.014
regulation of actin filament based processGO:00329701410.014
rna interferenceGO:001624640.013
spermatid developmentGO:000728640.013
dna damage checkpointGO:0000077680.013
cytokinesisGO:0000910960.013
regulation of protein localization to nucleusGO:1900180850.013
sequestering of calcium ionGO:0051208170.013
ribonucleoside monophosphate metabolic processGO:00091611870.013
positive regulation of immune responseGO:00507781590.013
cation homeostasisGO:00550801890.013
regulation of cell cycle checkpointGO:1901976210.013
chemotaxisGO:00069351570.013
peptidyl serine modificationGO:00182091060.013
secretion by cellGO:00329402260.013
regulation of purine nucleotide metabolic processGO:19005422640.013
nuclear importGO:00511701060.013
regulation of protein kinase activityGO:00458592890.013
neurotransmitter secretionGO:000726940.013
regulation of protein polymerizationGO:0032271630.013
inner ear morphogenesisGO:004247240.013
regulation of reactive oxygen species metabolic processGO:2000377410.013
neurological system processGO:00508771630.013
regulation of purine nucleotide catabolic processGO:00331212050.013
cytokine productionGO:00018162470.013
segmentationGO:003528240.013
brain developmentGO:0007420970.013
regulation of histone modificationGO:0031056470.013
hemopoiesisGO:00300971800.013
response to biotic stimulusGO:00096072760.013
regulation of protein targetingGO:1903533910.013
positive regulation of nucleotide catabolic processGO:00308131850.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
regulation of cell differentiationGO:00455953930.013
oocyte developmentGO:004859910.013
regulation of neuroblast proliferationGO:190269230.013
lipid biosynthetic processGO:00086101770.012
actin filament based movementGO:0030048170.012
positive regulation of programmed cell deathGO:00430682490.012
regulation of defense responseGO:00313471540.012
nucleoside monophosphate metabolic processGO:00091231910.012
regulation of innate immune responseGO:0045088970.012
peptidyl tyrosine phosphorylationGO:00181081700.012
regulation of endopeptidase activityGO:00525481700.012
actin cytoskeleton organizationGO:00300362070.012
neurogenesisGO:00220081690.012
protein importGO:00170381300.012
memoryGO:000761330.012
motor neuron axon guidanceGO:000804520.012
regulation of immune responseGO:00507762010.012
i kappab kinase nf kappab signalingGO:00072491660.012
regulation of nucleotide metabolic processGO:00061402690.012
regulation of gene expression epigeneticGO:0040029730.012
negative regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032435300.012
activation of immune responseGO:00022531140.012
regulation of cellular component sizeGO:0032535820.012
metal ion transportGO:00300012720.012
g protein coupled receptor signaling pathwayGO:00071862070.012
cellular lipid metabolic processGO:00442553030.012
nucleocytoplasmic transportGO:00069131760.012
regulation of neural precursor cell proliferationGO:200017740.012
immune response activating signal transductionGO:0002757900.012
cell projection assemblyGO:00300311260.012
regulation of anatomical structure sizeGO:00900661010.012
endocytosisGO:00068971590.012
biological adhesionGO:00226103310.012
regulation of actin cytoskeleton organizationGO:00329561160.012
regulation of chromatin modificationGO:1903308510.012
cellular chemical homeostasisGO:00550821800.012
single organism cell adhesionGO:00986021790.012
regulation of cellular component movementGO:00512703340.011
negative regulation of reactive oxygen species metabolic processGO:2000378110.011
regulation of intracellular protein transportGO:00331571230.011
regulation of peptidase activityGO:00525471800.011
single organism nuclear importGO:19025931040.011
response to cytokineGO:00340972320.011
positive regulation of synaptic transmissionGO:005080640.011
cellular metal ion homeostasisGO:00068751460.011
regulation of growth rateGO:004000910.011
negative regulation of phosphate metabolic processGO:00459362670.011
photoreceptor cell differentiationGO:004653020.011
regulation of hormone levelsGO:00108171250.011
rhythmic behaviorGO:000762220.011
positive regulation of secretionGO:00510471160.011
regulation of growthGO:00400081650.011
neuroblast proliferationGO:000740540.011
response to oxygen levelsGO:00704821000.011
negative regulation of dna metabolic processGO:0051053570.011
anterior posterior axis specificationGO:000994820.011
internal peptidyl lysine acetylationGO:0018393970.011
neuron developmentGO:00486661130.011
positive regulation of apoptotic processGO:00430652460.011
regulation of i kappab kinase nf kappab signalingGO:00431221620.011
regulation of nucleotide catabolic processGO:00308112050.011
cellular response to cytokine stimulusGO:00713451810.011
embryonic camera type eye developmentGO:003107620.011
response to transforming growth factor betaGO:0071559940.011
mitotic cell cycle checkpointGO:0007093680.011
positive regulation of ras gtpase activityGO:00323201170.011
tube closureGO:006060630.011
organelle localizationGO:0051640840.011
response to axon injuryGO:004867810.011
enzyme linked receptor protein signaling pathwayGO:00071673030.011
positive regulation of kinase activityGO:00336742040.011
positive regulation of gtp catabolic processGO:00331261660.011
nitrogen compound transportGO:00717051910.011
histone acetylationGO:0016573930.011
response to growth factorGO:00708482050.011
positive regulation of cell proliferationGO:00082843010.011
cellular response to transforming growth factor beta stimulusGO:0071560940.010
response to bacteriumGO:00096171440.010
pharynx developmentGO:006046510.010
inorganic ion transmembrane transportGO:00986602310.010
monocarboxylic acid metabolic processGO:00327871850.010
signal transduction by p53 class mediatorGO:0072331720.010
response to nitrogen compoundGO:19016981840.010
single organismal cell cell adhesionGO:00163371480.010
positive regulation of protein kinase activityGO:00458601900.010
regulation of cell migrationGO:00303342890.010
muscle system processGO:0003012810.010
cellular cation homeostasisGO:00300031630.010
peptidyl tyrosine modificationGO:00182121700.010
ion transmembrane transportGO:00342203380.010
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.010
morphogenesis of a polarized epitheliumGO:000173830.010
regulation of ras gtpase activityGO:00323181280.010
single organism reproductive processGO:0044702980.010
Mouse
cellular ion homeostasisGO:00068731680.010

HERC2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.026
musculoskeletal system diseaseDOID:172230.022
nervous system diseaseDOID:8634310.021
central nervous system diseaseDOID:3311860.021
sensory system diseaseDOID:00501552030.019
inherited metabolic disorderDOID:6552420.019
disease of cellular proliferationDOID:145661740.019
cancerDOID:1621670.019
organ system cancerDOID:00506861640.016
eye and adnexa diseaseDOID:14921500.014
eye diseaseDOID:56141490.013
retinal diseaseDOID:56791180.013
connective tissue diseaseDOID:651090.012
neurodegenerative diseaseDOID:12891020.012
retinal degenerationDOID:8466890.010