Homo sapiens

32 known processes

MKNK1

MAP kinase interacting serine/threonine kinase 1

(Aliases: MNK1)

MKNK1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to salt stressGO:000965130.570
Mouse
positive regulation of protein phosphorylationGO:00019343130.358
regulation of meiotic cell cycleGO:005144540.281
translational initiationGO:0006413480.260
Rat
regulation of translationGO:0006417890.212
Rat
meiosis iGO:000712740.146
dephosphorylationGO:00163112090.145
small gtpase mediated signal transductionGO:0007264780.142
Fly
posttranscriptional regulation of gene expressionGO:00106082130.140
Rat
regulation of meiosisGO:004002030.122
positive regulation of phosphorylationGO:00423273940.114
cell aggregationGO:009874310.114
negative regulation of catalytic activityGO:00430863350.107
response to abiotic stimulusGO:00096283360.107
Mouse
post embryonic developmentGO:000979120.100
p38mapk cascadeGO:003806690.098
cellular response to dna damage stimulusGO:00069743790.098
cellular amino acid metabolic processGO:00065201160.097
peptidyl serine modificationGO:00182091060.086
cellular amine metabolic processGO:0044106410.084
ras protein signal transductionGO:0007265730.081
Fly
regulation of cellular amino acid metabolic processGO:000652160.081
multicellular organismal agingGO:001025930.079
innate immune response activating signal transductionGO:0002758480.074
stress activated protein kinase signaling cascadeGO:0031098940.073
amine metabolic processGO:0009308440.069
regulation of protein serine threonine kinase activityGO:00719001790.069
regulation of cell cycle processGO:00105642660.068
response to cytokineGO:00340972320.067
signal transduction by phosphorylationGO:00230142970.066
jun phosphorylationGO:0007258280.065
nuclear divisionGO:00002801280.063
regulation of mapk cascadeGO:00434082620.062
positive regulation of immune system processGO:00026842830.061
regulation of cytokine productionGO:00018172320.060
lipid metabolic processGO:00066293810.060
regulation of cell cycleGO:00517263930.060
determination of adult lifespanGO:000834020.058
cellular ketone metabolic processGO:0042180800.058
female gamete generationGO:000729220.058
regulation of transferase activityGO:00513383550.057
positive regulation of hydrolase activityGO:00513453310.056
positive regulation of cellular amino acid metabolic processGO:004576430.056
mapk cascadeGO:00001652880.055
positive regulation of apoptotic processGO:00430652460.055
positive regulation of cell divisionGO:0051781590.055
regulation of kinase activityGO:00435493140.053
regulation of cellular ketone metabolic processGO:0010565500.053
oocyte developmentGO:004859910.053
positive regulation of cell sizeGO:004579330.053
translationGO:00064121320.053
Rat
cellular response to external stimulusGO:00714961110.052
organelle fissionGO:00482851490.052
system processGO:00030083490.051
stress activated mapk cascadeGO:0051403930.051
innate immune responseGO:00450871780.050
single organism carbohydrate metabolic processGO:00447231930.048
regulation of stress activated mapk cascadeGO:0032872840.048
immune response regulating signaling pathwayGO:0002764970.047
ion transmembrane transportGO:00342203380.047
response to biotic stimulusGO:00096072760.047
positive regulation of nuclear divisionGO:0051785270.046
response to inorganic substanceGO:00100351270.046
regulation of cellular amine metabolic processGO:0033238110.045
cellular response to oxygen containing compoundGO:19017012760.045
positive regulation of cell cycleGO:00457871400.045
sensory perception of painGO:001923340.044
positive regulation of protein kinase activityGO:00458601900.044
myoblast fusionGO:000752010.044
cytokine productionGO:00018162470.043
defense responseGO:00069523150.043
negative regulation of protein serine threonine kinase activityGO:0071901570.042
cardiac muscle contractionGO:0060048340.042
positive regulation of translationGO:0045727350.042
oogenesisGO:004847720.042
response to nitrosative stressGO:005140940.042
organic anion transportGO:00157111030.042
negative regulation of phosphorus metabolic processGO:00105632670.041
negative regulation of protein metabolic processGO:00512483910.041
regulation of translational initiationGO:0006446240.041
Rat
locomotory behaviorGO:000762610.041
peptidyl lysine modificationGO:00182051440.041
regulation of protein kinase activityGO:00458592890.041
positive regulation of defense responseGO:0031349870.041
positive regulation of immune responseGO:00507781590.041
regulation of map kinase activityGO:00434051080.040
negative regulation of cellular protein metabolic processGO:00322693530.039
immune responseGO:00069553070.038
cell morphogenesisGO:00009022960.038
positive regulation of cell cycle processGO:00900681060.038
protein localization to organelleGO:00333652800.038
cell junction maintenanceGO:003433140.037
positive regulation of programmed cell deathGO:00430682490.037
regulation of nucleotide catabolic processGO:00308112050.037
cell adhesionGO:00071553250.036
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.036
activation of protein kinase activityGO:0032147900.036
cellular response to growth factor stimulusGO:00713631970.036
negative regulation of protein phosphorylationGO:00019331400.035
positive regulation of fatty acid transportGO:200019330.035
positive regulation of catabolic processGO:00098963100.035
nervous system developmentGO:00073992930.034
positive regulation of meiosisGO:004583620.034
protein deubiquitinationGO:0016579790.034
response to oxygen containing compoundGO:19017003690.033
cellular response to endogenous stimulusGO:00714953360.033
chromatin modificationGO:00165682980.033
negative regulation of developmental processGO:00510932470.033
regulation of innate immune responseGO:0045088970.033
transmembrane transportGO:00550853990.033
rho protein signal transductionGO:0007266260.033
positive regulation of cellular amine metabolic processGO:003324070.032
positive regulation of transportGO:00510503360.032
oocyte maturationGO:000155610.032
peptidyl tyrosine dephosphorylationGO:0035335360.031
jnk cascadeGO:0007254800.031
negative regulation of erk1 and erk2 cascadeGO:0070373140.031
microtubule based processGO:00070172100.031
Fly
cation transportGO:00068123310.031
mitotic cell cycle processGO:19030472860.030
endomembrane system organizationGO:00102561960.030
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.030
cellular modified amino acid metabolic processGO:0006575640.030
cellular response to mechanical stimulusGO:0071260390.030
regulation of syncytium formation by plasma membrane fusionGO:006014220.030
activation of immune responseGO:00022531140.030
activation of innate immune responseGO:0002218550.029
positive regulation of ras gtpase activityGO:00323201170.029
mitotic cell cycleGO:00002783260.029
anion transportGO:00068201610.029
protein autophosphorylationGO:00467771230.028
cellular response to nitrogen compoundGO:19016991440.028
negative regulation of phosphate metabolic processGO:00459362670.028
hemopoiesisGO:00300971800.028
Human
negative regulation of transferase activityGO:00513481240.028
regenerationGO:003109940.028
cellular response to lipidGO:00713961270.027
defense response to other organismGO:00985421290.027
defense response to gram positive bacteriumGO:0050830290.027
neuromuscular junction developmentGO:000752830.027
rna processingGO:00063962550.027
positive regulation of cellular component organizationGO:00511303760.027
erk1 and erk2 cascadeGO:00703711040.027
maintenance of locationGO:00512351120.027
positive regulation of organic acid transportGO:003289230.027
regulation of peptidase activityGO:00525471800.027
internal protein amino acid acetylationGO:00064751010.026
ribonucleoside triphosphate catabolic processGO:00092033910.026
long chain fatty acid metabolic processGO:0001676300.026
nucleotide catabolic processGO:00091664080.026
lipid localizationGO:00108761060.026
regulation of erk1 and erk2 cascadeGO:0070372990.026
internal peptidyl lysine acetylationGO:0018393970.026
autophagyGO:0006914880.026
regulation of immune responseGO:00507762010.026
nucleoside triphosphate catabolic processGO:00091433940.026
response to growth factorGO:00708482050.026
response to oxidative stressGO:00069791210.026
regulation of jnk cascadeGO:0046328730.026
response to nitrogen compoundGO:19016981840.025
regulation of cell differentiationGO:00455953930.025
regulation of multi organism processGO:00439001570.025
response to lipidGO:00339932060.025
generation of neuronsGO:00486991520.025
regulation of nuclear divisionGO:0051783650.025
regulation of ras gtpase activityGO:00323181280.025
protein dephosphorylationGO:0006470810.025
purine ribonucleoside catabolic processGO:00461303980.025
positive regulation of nucleoside metabolic processGO:00459791860.024
oocyte differentiationGO:000999420.024
activation of mapk activityGO:0000187450.024
regulation of small gtpase mediated signal transductionGO:00510561560.024
Fly
mrna processingGO:00063971330.024
histone modificationGO:00165702510.024
histone serine phosphorylationGO:003540440.024
single organism membrane organizationGO:00448022680.024
mrna metabolic processGO:00160711750.024
peptidyl lysine acetylationGO:00183941010.024
cell activationGO:00017752130.024
hyperosmotic responseGO:000697240.024
wnt signaling pathwayGO:00160551560.023
negative regulation of phosphorylationGO:00423261740.023
cellular response to lipopolysaccharideGO:0071222570.023
positive regulation of innate immune responseGO:0045089790.023
negative regulation of kinase activityGO:00336731060.023
response to other organismGO:00517072610.023
negative regulation of mapk cascadeGO:0043409560.023
negative regulation of intracellular signal transductionGO:19025321830.023
Fly
syncytium formation by plasma membrane fusionGO:000076820.023
biological adhesionGO:00226103310.023
cytoplasmic transportGO:00164823790.023
positive regulation of gtp catabolic processGO:00331261660.022
actin filament based processGO:00300292240.022
response to bacteriumGO:00096171440.022
response to molecule of bacterial originGO:0002237820.022
cellular lipid metabolic processGO:00442553030.022
rna interferenceGO:001624640.022
histone acetylationGO:0016573930.022
peptidyl serine phosphorylationGO:00181051010.022
covalent chromatin modificationGO:00165692540.022
cellular response to abiotic stimulusGO:00712141170.022
cation homeostasisGO:00550801890.021
carbohydrate metabolic processGO:00059752070.021
purine ribonucleoside triphosphate catabolic processGO:00092073910.021
negative regulation of protein modification processGO:00314002000.021
skeletal muscle tissue regenerationGO:004340320.021
meiotic chromosome segregationGO:004513240.021
memoryGO:000761330.021
regulation of cellular response to stressGO:00801352440.021
response to radiationGO:00093141510.021
immune system developmentGO:00025201950.021
Human
positive regulation of cell proliferationGO:00082843010.021
purine nucleoside triphosphate catabolic processGO:00091463920.021
response to osmotic stressGO:0006970170.021
Mouse
protein catabolic processGO:00301633250.020
regulation of proteolysisGO:00301622930.020
positive regulation of mapk cascadeGO:00434101900.020
spindle elongationGO:005123140.020
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.020
protein processingGO:00164852260.020
response to mechanical stimulusGO:0009612510.020
reactive oxygen species metabolic processGO:0072593750.020
positive regulation of icosanoid secretionGO:003230530.020
establishment of protein localization to organelleGO:00725941720.020
response to nutrient levelsGO:0031667810.020
inactivation of mapk activityGO:000018850.020
alpha amino acid metabolic processGO:1901605720.020
regulation of tumor necrosis factor productionGO:0032680430.019
defense response to fungusGO:005083240.019
single organism reproductive processGO:0044702980.019
purine nucleotide catabolic processGO:00061954050.019
response to starvationGO:0042594590.019
t cell differentiation in thymusGO:003307740.019
positive regulation of ion transportGO:0043270870.019
positive regulation of nucleotide metabolic processGO:00459812300.019
mitotic nuclear divisionGO:00070671190.019
apoptotic signaling pathwayGO:00971902680.018
Mouse
purine nucleoside catabolic processGO:00061523980.018
response to fungusGO:000962040.018
regulation of response to external stimulusGO:00321012220.018
cellular response to molecule of bacterial originGO:0071219620.018
immune response activating signal transductionGO:0002757900.018
regulation of reactive oxygen species metabolic processGO:2000377410.018
peptidyl threonine modificationGO:0018210450.018
positive regulation of meiosis iGO:006090310.018
single organismal cell cell adhesionGO:00163371480.018
nuclear transportGO:00511691790.018
gtp metabolic processGO:00460392390.018
regulation of endopeptidase activityGO:00525481700.018
metal ion transportGO:00300012720.018
cation transmembrane transportGO:00986552380.018
cellular response to hormone stimulusGO:00328701250.018
protein maturationGO:00516042330.018
cellular response to nutrient levelsGO:0031669690.018
cellular response to biotic stimulusGO:0071216710.018
positive regulation of cell differentiationGO:00455972110.018
regulation of anatomical structure sizeGO:00900661010.018
regulation of cell substrate adhesionGO:0010810680.018
negative regulation of protein processingGO:00109551420.018
prostaglandin secretionGO:003231020.018
negative regulation of map kinase activityGO:0043407270.017
purine ribonucleotide catabolic processGO:00091544040.017
developmental programmed cell deathGO:001062330.017
positive regulation of nitric oxide synthase biosynthetic processGO:005177030.017
ion homeostasisGO:00508012300.017
regulation of defense responseGO:00313471540.017
regulation of nucleotide metabolic processGO:00061402690.017
regulation of protein localizationGO:00328802960.017
ribonucleoside triphosphate metabolic processGO:00091994120.017
protein modification by small protein removalGO:0070646920.017
regulation of cellular component sizeGO:0032535820.017
metal ion homeostasisGO:00550651690.017
reactive nitrogen species metabolic processGO:200105730.017
cellular component morphogenesisGO:00329893140.016
response to external biotic stimulusGO:00432072610.016
positive regulation of transferase activityGO:00513472270.016
regulation of purine nucleotide metabolic processGO:19005422640.016
peptidyl tyrosine phosphorylationGO:00181081700.016
single organism cellular localizationGO:19025803320.016
response to reactive oxygen speciesGO:0000302610.016
positive regulation of cellular catabolic processGO:00313312840.016
compound eye developmentGO:004874910.016
pattern recognition receptor signaling pathwayGO:0002221480.016
negative regulation of protein kinase activityGO:0006469980.016
extrinsic apoptotic signaling pathwayGO:00971911190.016
Mouse
response to muramyl dipeptideGO:003249540.016
cytokine mediated signaling pathwayGO:00192211090.016
defense response to bacteriumGO:0042742630.016
response to lipopolysaccharideGO:0032496700.016
anatomical structure homeostasisGO:00602491000.016
positive regulation of cell deathGO:00109422630.016
spermatid developmentGO:000728640.016
tissue regenerationGO:004224630.016
embryonic placenta developmentGO:000189210.016
ribonucleotide catabolic processGO:00092614050.016
regulation of neural precursor cell proliferationGO:200017740.016
regulation of stress activated protein kinase signaling cascadeGO:0070302850.015
nucleoside triphosphate metabolic processGO:00091414220.015
viral life cycleGO:00190581320.015
adult locomotory behaviorGO:000834410.015
monovalent inorganic cation transportGO:00156721280.015
arachidonic acid metabolic processGO:0019369140.015
protein acylationGO:00435431380.015
cellular response to cytokine stimulusGO:00713451810.015
regulation of gtpase activityGO:00430871800.015
regulation of protein catabolic processGO:00421761550.015
regulation of antimicrobial humoral responseGO:000275910.015
cell developmentGO:00484683280.015
paracrine signalingGO:003800110.015
lymphocyte activationGO:00466491330.015
cellular macromolecule catabolic processGO:00442653800.015
anatomical structure formation involved in morphogenesisGO:00486462840.015
positive regulation of purine nucleotide metabolic processGO:19005442270.015
spermatid differentiationGO:004851540.015
cellular cation homeostasisGO:00300031630.015
negative regulation of cell cycleGO:00457861930.015
neurological system processGO:00508771630.015
positive regulation of gtpase activityGO:00435471660.015
sensory perception of smellGO:000760820.015
cellular ion homeostasisGO:00068731680.015
positive regulation of syncytium formation by plasma membrane fusionGO:006014320.015
secretionGO:00469032540.015
secretion by cellGO:00329402260.015
regulation of prostaglandin secretionGO:003230620.015
positive regulation of kinase activityGO:00336742040.015
negative regulation of smoothened signaling pathwayGO:004587930.015
striated muscle contractionGO:0006941520.015
regulation of response to woundingGO:19030341010.015
negative regulation of cell differentiationGO:00455961710.015
proteolysis involved in cellular protein catabolic processGO:00516032440.015
regulation of rho protein signal transductionGO:0035023790.015
sequestering of metal ionGO:0051238240.015
regulation of nucleoside metabolic processGO:00091182090.014
response to uvGO:0009411730.014
glycosyl compound catabolic processGO:19016584130.014
positive regulation of map kinase activityGO:0043406800.014
negative regulation of apoptotic processGO:00430663160.014
protein k63 linked deubiquitinationGO:0070536210.014
cellular metal ion homeostasisGO:00068751460.014
photoreceptor cell differentiationGO:004653020.014
positive regulation of secretionGO:00510471160.014
ribonucleoside catabolic processGO:00424544060.014
membrane organizationGO:00610242920.014
organophosphate biosynthetic processGO:00904071630.014
positive regulation of protein transportGO:00512221350.014
muscle contractionGO:0006936730.014
cell cycle g1 s phase transitionGO:0044843800.014
somatic muscle developmentGO:000752510.014
macropinocytosisGO:004435110.014
carboxylic acid transportGO:0046942630.014
single organism cell adhesionGO:00986021790.014
purine ribonucleoside metabolic processGO:00461284370.014
associative learningGO:000830610.014
regulation of secretionGO:00510461940.014
guanosine containing compound catabolic processGO:19010692390.014
positive regulation of cell activationGO:0050867810.014
positive regulation of behaviorGO:0048520600.014
cell cell signalingGO:00072671550.014
reproductionGO:0000003630.014
cellular protein catabolic processGO:00442572610.014
positive regulation of protein serine threonine kinase activityGO:00719021190.014
protein acetylationGO:00064731160.014
purine containing compound catabolic processGO:00725234110.014
chromatin organizationGO:00063253510.014
blastoderm segmentationGO:000735020.013
positive regulation of meiotic cell cycleGO:005144620.013
muscle system processGO:0003012810.013
positive regulation of developmental processGO:00510943140.013
inorganic ion transmembrane transportGO:00986602310.013
negative regulation of hydrolase activityGO:00513461820.013
negative regulation of peptidase activityGO:0010466910.013
matingGO:000761810.013
protein localization to nucleusGO:00345041360.013
regulation of icosanoid secretionGO:003230340.013
positive regulation of reactive oxygen species metabolic processGO:2000379240.013
regulation of sequence specific dna binding transcription factor activityGO:00510902110.013
regulation of establishment of protein localizationGO:00702012420.013
response to axon injuryGO:004867810.013
purine nucleoside triphosphate metabolic processGO:00091444120.013
segmentationGO:003528240.013
carbohydrate derivative biosynthetic processGO:19011372070.013
intracellular protein transportGO:00068862700.013
behavioral response to ethanolGO:004814920.013
reactive oxygen species biosynthetic processGO:190340940.013
positive regulation of multi organism processGO:0043902560.013
regulation of chromosome organizationGO:00330441030.013
circulatory system developmentGO:00723592620.013
negative regulation of proteolysisGO:00458611320.013
negative regulation of cysteine type endopeptidase activityGO:2000117480.013
enzyme linked receptor protein signaling pathwayGO:00071673030.013
tor signalingGO:0031929390.013
nucleoside catabolic processGO:00091644080.013
morphogenesis of embryonic epitheliumGO:001633140.013
signal transduction by p53 class mediatorGO:0072331720.013
positive regulation of cytokine productionGO:00018191670.013
multi organism reproductive processGO:0044703540.013
positive regulation of purine nucleotide catabolic processGO:00331231850.013
organic acid transportGO:0015849650.013
t cell activationGO:0042110990.013
neural crest cell developmentGO:001403230.013
positive regulation of histone phosphorylationGO:003312930.013
rna splicingGO:00083801310.013
defense response to gram negative bacteriumGO:0050829140.013
response to metal ionGO:0010038840.013
positive regulation of myotube differentiationGO:001083130.013
response to hormoneGO:00097251750.013
positive regulation of mrna metabolic processGO:1903313190.013
neuroblast proliferationGO:000740540.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
negative regulation of wnt signaling pathwayGO:0030178690.012
protein oligomerizationGO:00512591730.012
behaviorGO:00076101120.012
release of cytoplasmic sequestered nf kappabGO:000858840.012
regulation of secretion by cellGO:19035301770.012
regulation of ras protein signal transductionGO:00465781550.012
Fly
reproductive processGO:00224141060.012
cellular response to transforming growth factor beta stimulusGO:0071560940.012
regulation of autophagyGO:0010506520.012
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.012
motor neuron axon guidanceGO:000804520.012
response to virusGO:00096151260.012
vasculature developmentGO:00019441810.012
regulation of myoblast fusionGO:190173910.012
proteasomal protein catabolic processGO:00104981760.012
negative regulation of cellular amine metabolic processGO:003323930.012
modification dependent protein catabolic processGO:00199412090.012
mrna splicing via spliceosomeGO:0000398890.012
mitotic spindle elongationGO:000002240.012
response to woundingGO:00096111680.012
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.012
positive regulation of leukocyte activationGO:0002696800.012
gtp catabolic processGO:00061842370.012
cell growthGO:00160491600.012
neurotransmitter secretionGO:000726940.012
regulation of protein stabilityGO:0031647870.012
peptidyl tyrosine modificationGO:00182121700.012
negative regulation of response to external stimulusGO:0032102830.012
regulation of glial cell differentiationGO:004568530.011
regulation of dephosphorylationGO:0035303960.011
cellular response to arsenic containing substanceGO:007124340.011
Human
guanosine containing compound metabolic processGO:19010682440.011
protein targetingGO:00066051870.011
divalent inorganic cation homeostasisGO:00725071360.011
regulation of purine nucleotide catabolic processGO:00331212050.011
visual learningGO:000854210.011
anterior posterior axis specificationGO:000994820.011
cellular response to reactive oxygen speciesGO:0034614500.011
peripheral nervous system developmentGO:000742220.011
cell substrate adhesionGO:00315891320.011
positive regulation of nucleotide catabolic processGO:00308131850.011
positive regulation of organelle organizationGO:00106381950.011
cardiac muscle cell contractionGO:008600340.011
regulation of wnt signaling pathwayGO:00301111230.011
cellular response to oxidative stressGO:0034599850.011
organophosphate catabolic processGO:00464344300.011
oxidation reduction processGO:00551143960.011
regulation of protein bindingGO:0043393660.011
organ formationGO:004864530.011
sex determinationGO:000753030.011
transforming growth factor beta receptor signaling pathwayGO:0007179760.011
regulation of phosphatase activityGO:0010921810.011
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.011
hexose metabolic processGO:0019318550.011
regulation of mitotic cell cycle phase transitionGO:19019901180.011
chemical homeostasisGO:00488783060.011
cellular response to extracellular stimulusGO:0031668720.011
lipid transportGO:0006869900.011
protein import into nucleusGO:00066061040.011
regulation of anatomical structure morphogenesisGO:00226032860.011
gastrulation with mouth forming secondGO:000170210.011
3 utr mediated mrna stabilizationGO:007093580.011
regulation of viral processGO:00507921030.011
cell fate determinationGO:000170930.011
positive regulation of protein catabolic processGO:0045732750.011

MKNK1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.055
central nervous system diseaseDOID:3311860.055
neurodegenerative diseaseDOID:12891020.043
disease of cellular proliferationDOID:145661740.024
organ system cancerDOID:00506861640.024
cancerDOID:1621670.024
musculoskeletal system diseaseDOID:172230.023
inherited metabolic disorderDOID:6552420.022
disease of metabolismDOID:00146672950.022
sensory system diseaseDOID:00501552030.015
immune system diseaseDOID:29141550.015
eye diseaseDOID:56141490.014
eye and adnexa diseaseDOID:14921500.014
muscle tissue diseaseDOID:661130.013
muscular diseaseDOID:00800001140.013
myopathyDOID:4231040.013
disease of mental healthDOID:150700.013
connective tissue diseaseDOID:651090.011
bone diseaseDOID:0080001880.011