Homo sapiens

68 known processes

STIM2

stromal interaction molecule 2

(Aliases: FLJ39527,KIAA1482)

STIM2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to histamineGO:007142030.123
determination of adult lifespanGO:000834020.095
small gtpase mediated signal transductionGO:0007264780.075
ion homeostasisGO:00508012300.071
multicellular organismal agingGO:001025930.064
cation transportGO:00068123310.064
ras protein signal transductionGO:0007265730.064
vesicle mediated transportGO:00161923710.060
nervous system developmentGO:00073992930.059
regulation of anatomical structure morphogenesisGO:00226032860.059
cellular ketone metabolic processGO:0042180800.058
purine ribonucleoside triphosphate catabolic processGO:00092073910.058
metal ion transportGO:00300012720.056
cell morphogenesisGO:00009022960.056
anatomical structure formation involved in morphogenesisGO:00486462840.053
protein ubiquitinationGO:00165673140.052
cellular amino acid metabolic processGO:00065201160.052
regulation of transferase activityGO:00513383550.051
regulation of protein serine threonine kinase activityGO:00719001790.049
regulation of mapk cascadeGO:00434082620.049
purine nucleoside triphosphate catabolic processGO:00091463920.049
actin filament based processGO:00300292240.048
positive regulation of mapk cascadeGO:00434101900.047
cellular component morphogenesisGO:00329893140.047
cellular amine metabolic processGO:0044106410.047
chemical homeostasisGO:00488783060.047
mitotic cell cycleGO:00002783260.047
regulation of cellular amino acid metabolic processGO:000652160.046
cellular macromolecule catabolic processGO:00442653800.046
post embryonic developmentGO:000979120.045
purine ribonucleoside catabolic processGO:00461303980.044
inorganic ion transmembrane transportGO:00986602310.043
positive regulation of developmental processGO:00510943140.043
regulation of mitotic cell cycleGO:00073461890.042
regulation of cell cycleGO:00517263930.042
purine ribonucleotide catabolic processGO:00091544040.042
system processGO:00030083490.042
purine nucleoside catabolic processGO:00061523980.041
positive regulation of cellular amino acid metabolic processGO:004576430.041
positive regulation of phosphorylationGO:00423273940.041
purine ribonucleoside triphosphate metabolic processGO:00092054110.040
histone modificationGO:00165702510.040
organophosphate catabolic processGO:00464344300.040
purine containing compound catabolic processGO:00725234110.040
secretionGO:00469032540.039
nucleoside phosphate catabolic processGO:19012924120.039
neurological system processGO:00508771630.039
negative regulation of protein metabolic processGO:00512483910.039
segmentationGO:003528240.039
protein modification by small protein conjugationGO:00324463420.039
mitotic cell cycle phase transitionGO:00447721620.039
ribonucleoside triphosphate metabolic processGO:00091994120.038
inorganic cation transmembrane transportGO:00986621940.038
protein autophosphorylationGO:00467771230.038
ion transmembrane transportGO:00342203380.038
regulation of cell morphogenesisGO:00226041530.037
purine nucleoside triphosphate metabolic processGO:00091444120.037
regulation of cellular amine metabolic processGO:0033238110.037
nucleotide catabolic processGO:00091664080.036
regulation of cellular ketone metabolic processGO:0010565500.036
positive regulation of erk1 and erk2 cascadeGO:0070374750.036
regulation of purine nucleotide metabolic processGO:19005422640.035
cell divisionGO:00513011680.035
cellular divalent inorganic cation homeostasisGO:00725031280.034
cellular cation homeostasisGO:00300031630.034
regulation of cell cycle processGO:00105642660.034
rho protein signal transductionGO:0007266260.033
chromatin modificationGO:00165682980.033
cation homeostasisGO:00550801890.033
negative regulation of cell deathGO:00605483450.033
compound eye developmentGO:004874910.033
positive regulation of catabolic processGO:00098963100.033
sequestering of metal ionGO:0051238240.033
signal transduction by phosphorylationGO:00230142970.033
negative regulation of apoptotic processGO:00430663160.032
single organism carbohydrate metabolic processGO:00447231930.032
locomotory behaviorGO:000762610.032
positive regulation of cell differentiationGO:00455972110.032
regulation of meiotic cell cycleGO:005144540.032
amine metabolic processGO:0009308440.032
nucleoside triphosphate catabolic processGO:00091433940.032
regulation of cell differentiationGO:00455953930.032
regulation of proteolysisGO:00301622930.032
divalent inorganic cation homeostasisGO:00725071360.032
positive regulation of immune system processGO:00026842830.032
cell projection organizationGO:00300302520.032
negative regulation of programmed cell deathGO:00430693210.032
glycosyl compound catabolic processGO:19016584130.031
cellular macromolecular complex assemblyGO:00346223240.031
ribonucleoside triphosphate catabolic processGO:00092033910.031
regulation of calcium ion transportGO:0051924790.031
positive regulation of cellular component organizationGO:00511303760.031
cell growthGO:00160491600.031
cellular response to endogenous stimulusGO:00714953360.031
calcium ion transportGO:00068161470.031
regulation of ion transportGO:00432691890.030
regulation of protein kinase activityGO:00458592890.030
positive regulation of cellular catabolic processGO:00313312840.030
regulation of nucleotide metabolic processGO:00061402690.030
regulation of kinase activityGO:00435493140.030
nucleoside triphosphate metabolic processGO:00091414220.030
actin mediated cell contractionGO:0070252120.030
actin filament based movementGO:0030048170.030
ribonucleoside catabolic processGO:00424544060.030
negative regulation of phosphate metabolic processGO:00459362670.030
ribonucleotide catabolic processGO:00092614050.029
positive regulation of transportGO:00510503360.029
regulation of ras protein signal transductionGO:00465781550.029
mitotic cell cycle processGO:19030472860.029
neurogenesisGO:00220081690.028
regulation of small gtpase mediated signal transductionGO:00510561560.028
cellular calcium ion homeostasisGO:00068741170.028
protein catabolic processGO:00301633250.028
anterior posterior axis specificationGO:000994820.028
lipid metabolic processGO:00066293810.028
innate immune responseGO:00450871780.028
i kappab kinase nf kappab signalingGO:00072491660.028
purine ribonucleoside metabolic processGO:00461284370.028
cell projection assemblyGO:00300311260.028
microtubule based processGO:00070172100.028
positive regulation of cellular amine metabolic processGO:003324070.028
purine nucleotide catabolic processGO:00061954050.028
carbohydrate metabolic processGO:00059752070.028
immune system developmentGO:00025201950.028
ubiquitin dependent protein catabolic processGO:00065112060.028
female gamete generationGO:000729220.027
biological adhesionGO:00226103310.027
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.027
enzyme linked receptor protein signaling pathwayGO:00071673030.027
blastoderm segmentationGO:000735020.027
maintenance of locationGO:00512351120.027
actin cytoskeleton organizationGO:00300362070.027
oogenesisGO:004847720.027
divalent inorganic cation transportGO:00725111580.027
regulation of protein complex assemblyGO:00432541470.027
phosphorylation of rna polymerase ii c terminal domainGO:007081630.027
regulation of cellular component movementGO:00512703340.027
negative regulation of phosphorus metabolic processGO:00105632670.026
regulation of map kinase activityGO:00434051080.026
nucleoside catabolic processGO:00091644080.026
secretion by cellGO:00329402260.026
metal ion homeostasisGO:00550651690.026
negative regulation of cellular protein metabolic processGO:00322693530.026
tripartite regional subdivisionGO:000735120.025
cation transmembrane transportGO:00986552380.025
hemopoiesisGO:00300971800.025
mapk cascadeGO:00001652880.025
immune responseGO:00069553070.025
positive regulation of purine nucleotide metabolic processGO:19005442270.025
cellular protein catabolic processGO:00442572610.025
negative regulation of catalytic activityGO:00430863350.025
positive regulation of nucleotide metabolic processGO:00459812300.025
cellular ion homeostasisGO:00068731680.025
regulation of protein localizationGO:00328802960.025
defense responseGO:00069523150.025
cellular protein complex assemblyGO:00436231880.024
spermatid developmentGO:000728640.024
response to organic cyclic compoundGO:00140702040.024
regulation of locomotionGO:00400123290.024
neuron differentiationGO:00301821380.024
response to growth factorGO:00708482050.024
regulation of mitotic cell cycle phase transitionGO:19019901180.024
cytoplasmic transportGO:00164823790.024
endomembrane system organizationGO:00102561960.024
regulation of response to external stimulusGO:00321012220.024
chromatin organizationGO:00063253510.023
cellular response to growth factor stimulusGO:00713631970.023
apoptotic signaling pathwayGO:00971902680.023
negative regulation of protein modification processGO:00314002000.023
membrane organizationGO:00610242920.023
positive regulation of hydrolase activityGO:00513453310.023
neuromuscular junction developmentGO:000752830.023
erk1 and erk2 cascadeGO:00703711040.023
cell cycle phase transitionGO:00447701730.023
carbohydrate derivative biosynthetic processGO:19011372070.023
proteolysis involved in cellular protein catabolic processGO:00516032440.023
regulation of proteasomal protein catabolic processGO:0061136870.023
embryonic camera type eye developmentGO:003107620.023
morphogenesis of embryonic epitheliumGO:001633140.023
spermatid differentiationGO:004851540.022
calcium ion homeostasisGO:00550741220.022
negative regulation of cellular component organizationGO:00511292350.022
regulation of nucleoside metabolic processGO:00091182090.022
cellular response to dna damage stimulusGO:00069743790.022
embryonic camera type eye morphogenesisGO:004859620.022
taxisGO:00423301570.022
growthGO:00400072020.022
proteasomal protein catabolic processGO:00104981760.022
regenerationGO:003109940.022
calcium ion transmembrane transportGO:0070588760.022
negative regulation of cellular amino acid metabolic processGO:004576320.022
regulation of axon guidanceGO:190266730.022
negative regulation of hydrolase activityGO:00513461820.022
regulation of cytoskeleton organizationGO:00514931770.022
cell adhesionGO:00071553250.021
memoryGO:000761330.021
regulation of cellular response to stressGO:00801352440.021
organonitrogen compound biosynthetic processGO:19015662000.021
dephosphorylationGO:00163112090.021
regulation of cellular component biogenesisGO:00440872810.021
sequestering of calcium ionGO:0051208170.021
regulation of cell migrationGO:00303342890.021
modification dependent macromolecule catabolic processGO:00436322120.020
anterior posterior axis specification embryoGO:000859520.020
cellular lipid metabolic processGO:00442553030.020
negative regulation of intracellular signal transductionGO:19025321830.020
cellular response to oxygen containing compoundGO:19017012760.020
regulation of homeostatic processGO:00328441210.020
response to woundingGO:00096111680.020
regulation of protein catabolic processGO:00421761550.020
neuron projection developmentGO:00311751060.020
cellular homeostasisGO:00197251960.020
positive regulation of gtp catabolic processGO:00331261660.019
hematopoietic or lymphoid organ developmentGO:00485341860.019
regulation of cell motilityGO:20001452990.019
regulation of cell projection organizationGO:00313441070.019
regulation of cell cycle phase transitionGO:19019871260.019
endocytosisGO:00068971590.019
regulation of actin filament based processGO:00329701410.019
regulation of actin filament lengthGO:0030832560.019
positive regulation of purine nucleotide catabolic processGO:00331231850.019
protein localization to organelleGO:00333652800.019
organelle assemblyGO:00709251760.019
regulation of response to woundingGO:19030341010.019
meiosis iGO:000712740.019
embryonic eye morphogenesisGO:004804820.019
response to abiotic stimulusGO:00096283360.019
cardiovascular system developmentGO:00723582620.019
rna processingGO:00063962550.018
protein processingGO:00164852260.018
positive regulation of nucleotide catabolic processGO:00308131850.018
guanosine containing compound metabolic processGO:19010682440.018
regulation of apoptotic signaling pathwayGO:20012331750.018
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.018
motor neuron axon guidanceGO:000804520.018
gtp catabolic processGO:00061842370.018
intrinsic apoptotic signaling pathwayGO:00971931270.018
regulation of cellular protein catabolic processGO:1903362960.018
modification dependent protein catabolic processGO:00199412090.018
regulation of metal ion transportGO:00109591200.018
response to biotic stimulusGO:00096072760.018
regulation of nucleotide catabolic processGO:00308112050.018
regulation of erk1 and erk2 cascadeGO:0070372990.018
negative regulation of cellular amine metabolic processGO:003323930.018
regulation of sequence specific dna binding transcription factor activityGO:00510902110.017
sensory perceptionGO:00076001030.017
epithelium developmentGO:00604292270.017
positive regulation of organelle organizationGO:00106381950.017
covalent chromatin modificationGO:00165692540.017
cytokine productionGO:00018162470.017
lipid biosynthetic processGO:00086101770.017
cellular response to nitrogen compoundGO:19016991440.017
regulation of immune responseGO:00507762010.017
urea metabolic processGO:001962730.017
organic hydroxy compound metabolic processGO:19016151470.017
regulation of synaptic plasticityGO:004816730.017
transmembrane transportGO:00550853990.017
cellular response to organonitrogen compoundGO:00714171240.017
nucleoside monophosphate metabolic processGO:00091231910.017
tissue morphogenesisGO:0048729960.017
glycoprotein metabolic processGO:00091001100.017
lung alveolus developmentGO:004828640.017
response to nitrogen compoundGO:19016981840.017
gtp metabolic processGO:00460392390.017
regulation of cell growthGO:00015581350.016
posttranscriptional regulation of gene expressionGO:00106082130.016
regulation of purine nucleotide catabolic processGO:00331212050.016
associative learningGO:000830610.016
regulation of axon extension involved in axon guidanceGO:004884120.016
cellular response to ammonium ionGO:007124240.016
protein maturationGO:00516042330.016
wnt signaling pathwayGO:00160551560.016
positive regulation of cell proliferationGO:00082843010.016
leukocyte differentiationGO:0002521980.016
organophosphate biosynthetic processGO:00904071630.016
chemotaxisGO:00069351570.016
single organism reproductive processGO:0044702980.016
cell developmentGO:00484683280.016
photoreceptor cell differentiationGO:004653020.016
regulation of intracellular transportGO:00323861950.016
vasculature developmentGO:00019441810.016
regulation of gtpase activityGO:00430871800.016
regulation of transporter activityGO:0032409820.015
regulation of actin cytoskeleton organizationGO:00329561160.015
response to cytokineGO:00340972320.015
regulation of transmembrane transportGO:00347621390.015
small molecule biosynthetic processGO:00442831570.015
oocyte developmentGO:004859910.015
microtubule cytoskeleton organizationGO:00002261760.015
blastocyst developmentGO:000182430.015
regulation of microtubule based processGO:0032886740.015
single organism cellular localizationGO:19025803320.015
anion transportGO:00068201610.015
lens development in camera type eyeGO:000208820.015
guanosine containing compound catabolic processGO:19010692390.015
embryonic epithelial tube formationGO:000183840.015
purine ribonucleoside monophosphate metabolic processGO:00091671860.015
positive regulation of transferase activityGO:00513472270.015
regulation of protein modification by small protein conjugation or removalGO:19033201070.015
negative regulation of rho gtpase activityGO:003425940.015
circulatory system developmentGO:00723592620.014
regulation of wnt signaling pathwayGO:00301111230.014
cell fate determinationGO:000170930.014
positive regulation of cellular component biogenesisGO:00440891580.014
visual learningGO:000854210.014
glycoprotein biosynthetic processGO:0009101910.014
reproductive processGO:00224141060.014
negative regulation of cellular catabolic processGO:0031330830.014
cytokine mediated signaling pathwayGO:00192211090.014
regulation of anatomical structure sizeGO:00900661010.014
rna interferenceGO:001624640.014
positive regulation of cell deathGO:00109422630.014
regulation of transmembrane transporter activityGO:0022898740.014
immune effector processGO:00022521590.014
negative regulation of protein processingGO:00109551420.014
protein oligomerizationGO:00512591730.014
positive regulation of apoptotic processGO:00430652460.014
cellular response to organic cyclic compoundGO:00714071270.014
cell part morphogenesisGO:00329901370.014
positive regulation of cell cycle processGO:00900681060.014
response to axon injuryGO:004867810.014
matingGO:000761810.014
purine nucleoside monophosphate metabolic processGO:00091261860.014
protein glycosylationGO:0006486620.014
stem cell divisionGO:001714520.014
protein acylationGO:00435431380.014
positive regulation of synaptic transmissionGO:005080640.014
response to organonitrogen compoundGO:00102431560.014
embryonic morphogenesisGO:0048598850.014
rhythmic behaviorGO:000762220.014
ribonucleoside monophosphate metabolic processGO:00091611870.014
oxidation reduction processGO:00551143960.014
protein polymerizationGO:0051258710.013
positive regulation of stress activated protein kinase signaling cascadeGO:0070304610.013
positive regulation of protein phosphorylationGO:00019343130.013
cytokinesisGO:0000910960.013
response to other organismGO:00517072610.013
negative regulation of phosphorylationGO:00423261740.013
head developmentGO:00603221080.013
response to external biotic stimulusGO:00432072610.013
divalent metal ion transportGO:00708381520.013
adult locomotory behaviorGO:000834410.013
cellular chemical homeostasisGO:00550821800.013
nitrogen compound transportGO:00717051910.013
visual behaviorGO:000763220.013
regulation of gtp catabolic processGO:00331241800.013
cellular response to cytokine stimulusGO:00713451810.013
neural tube formationGO:000184130.013
positive regulation of gtpase activityGO:00435471660.013
negative regulation of cell cycleGO:00457861930.013
axon cargo transportGO:000808820.013
central nervous system developmentGO:00074171230.013
atp metabolic processGO:00460341760.013
positive regulation of kinase activityGO:00336742040.013
regulation of cytoplasmic transportGO:19036491490.013
circadian behaviorGO:004851220.013
regulation of ion homeostasisGO:2000021730.013
nucleotide biosynthetic processGO:00091651090.013
negative regulation of organelle organizationGO:00106391260.013
single organism cell adhesionGO:00986021790.013
negative regulation of protein phosphorylationGO:00019331400.013
cardiac muscle cell contractionGO:008600340.013
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.013
regulation of secretion by cellGO:19035301770.013
purine ribonucleotide biosynthetic processGO:0009152790.013
negative regulation of cell proliferationGO:00082852280.013
embryo developmentGO:00097901230.013
sensory perception of soundGO:0007605370.013
single organism membrane organizationGO:00448022680.013
axon regenerationGO:003110310.013
response to oxidative stressGO:00069791210.012
neuroblast proliferationGO:000740540.012
regulation of protein transportGO:00512232130.012
positive regulation of nucleoside metabolic processGO:00459791860.012
protein acetylationGO:00064731160.012
regulation of hormone levelsGO:00108171250.012
peptidyl tyrosine modificationGO:00182121700.012
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.012
cellular response to oxidative stressGO:0034599850.012
oocyte differentiationGO:000999420.012
regulation of ion transmembrane transporter activityGO:0032412720.012
blood vessel developmentGO:00015681720.012
positive regulation of cytosolic calcium ion concentrationGO:0007204820.012
ribonucleoside monophosphate catabolic processGO:00091581580.012
muscle contractionGO:0006936730.012
regulation of calcium ion transmembrane transporter activityGO:1901019280.012
regulation of i kappab kinase nf kappab signalingGO:00431221620.012
maintenance of location in cellGO:0051651620.012
regulation of cell morphogenesis involved in differentiationGO:0010769830.012
cellular metal ion homeostasisGO:00068751460.012
actin polymerization or depolymerizationGO:0008154560.012
wound healingGO:00420601150.012
syncytium formation by plasma membrane fusionGO:000076820.012
regulation of vasculature developmentGO:1901342970.012
establishment or maintenance of apical basal cell polarityGO:003508820.012
regulation of actin filament polymerizationGO:0030833500.012
dna packagingGO:0006323770.012
regulation of protein ubiquitinationGO:0031396950.012
intracellular receptor signaling pathwayGO:00305221040.012
nuclear divisionGO:00002801280.012
reactive oxygen species biosynthetic processGO:190340940.012
regulation of cell divisionGO:00513021160.012
methylationGO:00322591060.012
protein targetingGO:00066051870.012
organelle fissionGO:00482851490.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
purine nucleoside monophosphate catabolic processGO:00091281580.012
cellular carbohydrate metabolic processGO:0044262840.012
regulation of ras gtpase activityGO:00323181280.012
actin filament organizationGO:00070151280.012
single organismal cell cell adhesionGO:00163371480.012
intracellular protein transportGO:00068862700.012
regulation of establishment of protein localizationGO:00702012420.012
inner ear morphogenesisGO:004247240.012
positive regulation of cell cycleGO:00457871400.012
nerve developmentGO:002167540.012
regulation of peptidase activityGO:00525471800.012
g1 s transition of mitotic cell cycleGO:0000082780.012
organ formationGO:004864530.012
brain developmentGO:0007420970.012
regulation of cytokine productionGO:00018172320.012
positive regulation of locomotionGO:00400171860.012
regulation of endopeptidase activityGO:00525481700.012
glycosylationGO:0070085710.012
ribonucleotide biosynthetic processGO:0009260810.011
cell cell signalingGO:00072671550.011
peptidyl lysine acetylationGO:00183941010.011
negative regulation of catabolic processGO:00098951040.011
protein stabilizationGO:0050821640.011
neurotransmitter secretionGO:000726940.011
negative regulation of protein maturationGO:19033181420.011
somitogenesisGO:000175620.011
ameboidal type cell migrationGO:00016671350.011
neuron developmentGO:00486661130.011
regulation of cell adhesionGO:00301551660.011
plasma membrane organizationGO:00070091150.011
positive regulation of programmed cell deathGO:00430682490.011
regulation of defense responseGO:00313471540.011
regulation of neural precursor cell proliferationGO:200017740.011
metencephalon developmentGO:002203720.011
response to oxygen levelsGO:00704821000.011
regulation of protein maturationGO:19033171500.011
l amino acid importGO:004309240.011
cell substrate adhesionGO:00315891320.011
cell cycle g1 s phase transitionGO:0044843800.011
cell projection morphogenesisGO:00488581290.011
regulation of meiosisGO:004002030.011
rna splicingGO:00083801310.011
positive regulation of immune responseGO:00507781590.011
stress activated protein kinase signaling cascadeGO:0031098940.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.011
monocarboxylic acid metabolic processGO:00327871850.011
reactive oxygen species metabolic processGO:0072593750.011
hindbrain developmentGO:003090230.011
protein localization to membraneGO:00726571600.011
regulation of growthGO:00400081650.011
purine ribonucleoside monophosphate catabolic processGO:00091691580.011
tube closureGO:006060630.011
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.011
response to decreased oxygen levelsGO:0036293960.011
positive regulation of transporter activityGO:0032411320.011
regulation of ion transmembrane transportGO:00347651320.011
ossificationGO:00015031210.011
cerebellum developmentGO:002154920.011
regulation of secretionGO:00510461940.011
macromolecule methylationGO:0043414970.011
organ morphogenesisGO:00098871470.011
macromolecule glycosylationGO:0043413630.011
pharynx developmentGO:006046510.011
regulation of cysteine type endopeptidase activityGO:20001161270.011
convergent extensionGO:006002610.011
protein secretionGO:0009306980.011

STIM2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.038
sensory system diseaseDOID:00501552030.038
central nervous system diseaseDOID:3311860.032
cardiovascular system diseaseDOID:12871060.024
neurodegenerative diseaseDOID:12891020.022
musculoskeletal system diseaseDOID:172230.020
disease of metabolismDOID:00146672950.019
auditory system diseaseDOID:2742530.019
muscular diseaseDOID:00800001140.019
myopathyDOID:4231040.019
muscle tissue diseaseDOID:661130.019
connective tissue diseaseDOID:651090.018
disease of cellular proliferationDOID:145661740.017
bone diseaseDOID:0080001880.017
organ system cancerDOID:00506861640.015
cancerDOID:1621670.015
nonsyndromic deafnessDOID:0050563500.013
inherited metabolic disorderDOID:6552420.013
immune system diseaseDOID:29141550.013
physical disorderDOID:0080015410.011
congenital nervous system abnormalityDOID:2490210.011