Homo sapiens

42 known processes

PLEKHF1

pleckstrin homology domain containing, family F (with FYVE domain) member 1

(Aliases: MGC4090,APPD,PHAFIN1,ZFYVE15)

PLEKHF1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.057
post embryonic developmentGO:000979120.055
purine ribonucleoside metabolic processGO:00461284370.048
amine metabolic processGO:0009308440.046
cellular amine metabolic processGO:0044106410.046
organophosphate catabolic processGO:00464344300.045
regulation of cellular amino acid metabolic processGO:000652160.045
regulation of cellular ketone metabolic processGO:0010565500.045
positive regulation of cellular amine metabolic processGO:003324070.044
ribonucleoside catabolic processGO:00424544060.044
purine nucleoside catabolic processGO:00061523980.044
cellular ketone metabolic processGO:0042180800.043
regulation of cellular amine metabolic processGO:0033238110.043
purine nucleotide catabolic processGO:00061954050.043
glycosyl compound catabolic processGO:19016584130.043
positive regulation of catabolic processGO:00098963100.041
nucleotide catabolic processGO:00091664080.041
purine ribonucleoside triphosphate metabolic processGO:00092054110.041
purine ribonucleoside catabolic processGO:00461303980.040
determination of adult lifespanGO:000834020.040
multicellular organismal agingGO:001025930.040
nucleoside catabolic processGO:00091644080.040
purine ribonucleotide catabolic processGO:00091544040.040
purine containing compound catabolic processGO:00725234110.040
ribonucleoside triphosphate metabolic processGO:00091994120.039
purine nucleoside triphosphate metabolic processGO:00091444120.039
positive regulation of hydrolase activityGO:00513453310.038
positive regulation of cellular amino acid metabolic processGO:004576430.038
purine nucleoside triphosphate catabolic processGO:00091463920.038
positive regulation of cellular catabolic processGO:00313312840.037
nucleoside triphosphate catabolic processGO:00091433940.037
ribonucleotide catabolic processGO:00092614050.037
purine ribonucleoside triphosphate catabolic processGO:00092073910.037
ribonucleoside triphosphate catabolic processGO:00092033910.036
system processGO:00030083490.036
immune responseGO:00069553070.035
nucleoside phosphate catabolic processGO:19012924120.033
regulation of cell differentiationGO:00455953930.033
nucleoside triphosphate metabolic processGO:00091414220.033
negative regulation of phosphate metabolic processGO:00459362670.032
positive regulation of phosphorylationGO:00423273940.032
ras protein signal transductionGO:0007265730.032
negative regulation of catalytic activityGO:00430863350.032
locomotory behaviorGO:000762610.031
regulation of nucleotide metabolic processGO:00061402690.031
regulation of purine nucleotide metabolic processGO:19005422640.031
small gtpase mediated signal transductionGO:0007264780.031
negative regulation of multicellular organismal processGO:00512413170.030
regulation of transferase activityGO:00513383550.030
lipid metabolic processGO:00066293810.030
cellular macromolecule catabolic processGO:00442653800.029
positive regulation of cell proliferationGO:00082843010.029
response to abiotic stimulusGO:00096283360.029
segmentationGO:003528240.029
actin filament based processGO:00300292240.029
negative regulation of phosphorus metabolic processGO:00105632670.029
positive regulation of purine nucleotide metabolic processGO:19005442270.029
female gamete generationGO:000729220.028
cellular macromolecular complex assemblyGO:00346223240.028
negative regulation of protein metabolic processGO:00512483910.028
positive regulation of nucleotide metabolic processGO:00459812300.028
actin mediated cell contractionGO:0070252120.028
oogenesisGO:004847720.028
single organism cellular localizationGO:19025803320.027
regulation of locomotionGO:00400123290.027
response to oxygen containing compoundGO:19017003690.027
cellular lipid metabolic processGO:00442553030.027
negative regulation of cellular protein metabolic processGO:00322693530.027
regulation of nucleotide catabolic processGO:00308112050.027
regulation of kinase activityGO:00435493140.026
regulation of cellular component movementGO:00512703340.026
cytoplasmic transportGO:00164823790.026
Fly
cell adhesionGO:00071553250.026
transmembrane transportGO:00550853990.026
actin filament based movementGO:0030048170.026
positive regulation of transportGO:00510503360.026
biological adhesionGO:00226103310.025
positive regulation of immune system processGO:00026842830.025
positive regulation of protein phosphorylationGO:00019343130.025
positive regulation of nucleoside metabolic processGO:00459791860.025
signal transduction by phosphorylationGO:00230142970.025
protein catabolic processGO:00301633250.025
regulation of purine nucleotide catabolic processGO:00331212050.025
regulation of cell cycleGO:00517263930.024
regulation of anatomical structure morphogenesisGO:00226032860.024
positive regulation of nucleotide catabolic processGO:00308131850.024
cellular response to dna damage stimulusGO:00069743790.024
positive regulation of transferase activityGO:00513472270.024
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.024
positive regulation of purine nucleotide catabolic processGO:00331231850.024
voluntary skeletal muscle contractionGO:000301010.024
regulation of nucleoside metabolic processGO:00091182090.024
ribonucleoside monophosphate metabolic processGO:00091611870.023
cytokine productionGO:00018162470.023
protein localization to organelleGO:00333652800.023
cellular component morphogenesisGO:00329893140.023
Fly
regenerationGO:003109940.023
mitotic cell cycleGO:00002783260.023
single organism membrane organizationGO:00448022680.023
maintenance of locationGO:00512351120.023
purine ribonucleoside monophosphate metabolic processGO:00091671860.023
regulation of protein kinase activityGO:00458592890.023
neuromuscular junction developmentGO:000752830.022
carbohydrate metabolic processGO:00059752070.022
regulation of cell motilityGO:20001452990.022
regulation of cell migrationGO:00303342890.022
defense responseGO:00069523150.022
negative regulation of cell proliferationGO:00082852280.022
positive regulation of developmental processGO:00510943140.022
membrane organizationGO:00610242920.022
mapk cascadeGO:00001652880.022
intracellular protein transportGO:00068862700.022
enzyme linked receptor protein signaling pathwayGO:00071673030.022
negative regulation of cell deathGO:00605483450.021
regulation of protein localizationGO:00328802960.021
positive regulation of cell deathGO:00109422630.021
Mouse
negative regulation of programmed cell deathGO:00430693210.021
single organism carbohydrate metabolic processGO:00447231930.021
guanosine containing compound catabolic processGO:19010692390.021
positive regulation of cellular component organizationGO:00511303760.021
rhythmic behaviorGO:000762220.021
gtp metabolic processGO:00460392390.021
rho protein signal transductionGO:0007266260.021
regulation of response to external stimulusGO:00321012220.021
proteolysis involved in cellular protein catabolic processGO:00516032440.021
atp metabolic processGO:00460341760.021
lipid biosynthetic processGO:00086101770.021
response to external biotic stimulusGO:00432072610.021
cell developmentGO:00484683280.021
Fly
nucleoside monophosphate metabolic processGO:00091231910.021
metal ion transportGO:00300012720.021
cation transmembrane transportGO:00986552380.021
apoptotic signaling pathwayGO:00971902680.021
Mouse
cellular protein catabolic processGO:00442572610.020
regulation of cytokine productionGO:00018172320.020
negative regulation of hydrolase activityGO:00513461820.020
regulation of cellular response to stressGO:00801352440.020
negative regulation of apoptotic processGO:00430663160.020
protein maturationGO:00516042330.020
positive regulation of protein kinase activityGO:00458601900.020
blastoderm segmentationGO:000735020.020
carbohydrate derivative biosynthetic processGO:19011372070.020
positive regulation of kinase activityGO:00336742040.020
regulation of cell cycle processGO:00105642660.020
cation transportGO:00068123310.020
circulatory system developmentGO:00723592620.020
anterior posterior axis specificationGO:000994820.020
vesicle mediated transportGO:00161923710.020
Fly
organelle assemblyGO:00709251760.020
cellular response to endogenous stimulusGO:00714953360.020
gtp catabolic processGO:00061842370.020
negative regulation of cellular amino acid metabolic processGO:004576320.020
positive regulation of cell differentiationGO:00455972110.020
memoryGO:000761330.019
protein ubiquitinationGO:00165673140.019
negative regulation of cellular amine metabolic processGO:003323930.019
cellular response to oxygen containing compoundGO:19017012760.019
oxidation reduction processGO:00551143960.019
purine nucleoside monophosphate metabolic processGO:00091261860.019
actin cytoskeleton organizationGO:00300362070.019
chemical homeostasisGO:00488783060.019
guanosine containing compound metabolic processGO:19010682440.019
ion transmembrane transportGO:00342203380.019
hematopoietic or lymphoid organ developmentGO:00485341860.019
anatomical structure formation involved in morphogenesisGO:00486462840.019
regulation of intracellular transportGO:00323861950.019
protein modification by small protein conjugationGO:00324463420.019
circadian behaviorGO:004851220.019
positive regulation of apoptotic processGO:00430652460.019
Mouse
small molecule biosynthetic processGO:00442831570.019
regulation of proteolysisGO:00301622930.019
muscle contractionGO:0006936730.019
cell morphogenesisGO:00009022960.018
Fly
cellular protein complex assemblyGO:00436231880.018
striated muscle contractionGO:0006941520.018
mitotic cell cycle processGO:19030472860.018
positive regulation of programmed cell deathGO:00430682490.018
Mouse
regulation of establishment of protein localizationGO:00702012420.018
morphogenesis of embryonic epitheliumGO:001633140.018
immune system developmentGO:00025201950.018
adult locomotory behaviorGO:000834410.018
cardiac muscle cell contractionGO:008600340.018
secretion by cellGO:00329402260.018
regulation of cell adhesionGO:00301551660.018
cell fate determinationGO:000170930.017
dephosphorylationGO:00163112090.017
protein processingGO:00164852260.017
positive regulation of mapk cascadeGO:00434101900.017
negative regulation of protein modification processGO:00314002000.017
negative regulation of developmental processGO:00510932470.017
organonitrogen compound biosynthetic processGO:19015662000.017
monocarboxylic acid metabolic processGO:00327871850.017
hemopoiesisGO:00300971800.017
oocyte developmentGO:004859910.017
response to biotic stimulusGO:00096072760.017
positive regulation of gtp catabolic processGO:00331261660.017
regulation of neural precursor cell proliferationGO:200017740.017
nitrogen compound transportGO:00717051910.017
response to other organismGO:00517072610.017
hindbrain developmentGO:003090230.017
protein targetingGO:00066051870.017
modification dependent macromolecule catabolic processGO:00436322120.017
negative regulation of intracellular signal transductionGO:19025321830.017
innate immune responseGO:00450871780.017
nervous system developmentGO:00073992930.017
Fly
purine ribonucleoside monophosphate catabolic processGO:00091691580.016
negative regulation of cellular component organizationGO:00511292350.016
ubiquitin dependent protein catabolic processGO:00065112060.016
regulation of immune responseGO:00507762010.016
cell activationGO:00017752130.016
spermatid differentiationGO:004851540.016
neurotransmitter secretionGO:000726940.016
forelimb morphogenesisGO:003513640.016
regulation of gtp catabolic processGO:00331241800.016
organic acid biosynthetic processGO:0016053970.016
inorganic ion transmembrane transportGO:00986602310.016
embryonic epithelial tube formationGO:000183840.016
purine nucleoside monophosphate catabolic processGO:00091281580.016
ribonucleoside monophosphate catabolic processGO:00091581580.016
nucleoside monophosphate catabolic processGO:00091251590.016
secretionGO:00469032540.016
positive regulation of odontogenesisGO:004248230.016
atp catabolic processGO:00062001570.016
positive regulation of organelle organizationGO:00106381950.016
oocyte differentiationGO:000999420.016
spinal cord developmentGO:002151040.016
proteasomal protein catabolic processGO:00104981760.016
tripartite regional subdivisionGO:000735120.016
regulation of protein transportGO:00512232130.016
compound eye developmentGO:004874910.016
inorganic cation transmembrane transportGO:00986621940.016
endomembrane system organizationGO:00102561960.016
posttranscriptional regulation of gene expressionGO:00106082130.016
neuroblast proliferationGO:000740540.016
ion homeostasisGO:00508012300.015
modification dependent protein catabolic processGO:00199412090.015
cell projection organizationGO:00300302520.015
Fly
anterior posterior axis specification embryoGO:000859520.015
peripheral nervous system developmentGO:000742220.015
inner ear morphogenesisGO:004247240.015
spermatid developmentGO:000728640.015
positive regulation of cell migrationGO:00303351720.015
regulation of gtpase activityGO:00430871800.015
cardiovascular system developmentGO:00723582620.015
protein oligomerizationGO:00512591730.015
myosin filament assemblyGO:003103420.015
organ formationGO:004864530.015
release of cytoplasmic sequestered nf kappabGO:000858840.015
sex determinationGO:000753030.015
carboxylic acid biosynthetic processGO:0046394970.015
cellular homeostasisGO:00197251960.015
regulation of mitotic cell cycleGO:00073461890.015
regulation of ras protein signal transductionGO:00465781550.015
lipid localizationGO:00108761060.015
regulation of protein catabolic processGO:00421761550.015
syncytium formation by plasma membrane fusionGO:000076820.015
positive regulation of cellular component movementGO:00512721810.015
embryonic forelimb morphogenesisGO:003511540.015
negative regulation of phosphorylationGO:00423261740.015
i kappab kinase nf kappab signalingGO:00072491660.015
histone modificationGO:00165702510.015
twitch skeletal muscle contractionGO:001472110.015
growthGO:00400072020.015
negative regulation of cell cycleGO:00457861930.015
circulatory system processGO:00030131130.015
reactive oxygen species biosynthetic processGO:190340940.015
positive regulation of immune responseGO:00507781590.015
regulation of sequence specific dna binding transcription factor activityGO:00510902110.015
reactive oxygen species metabolic processGO:0072593750.014
blood vessel morphogenesisGO:00485141620.014
striated muscle myosin thick filament assemblyGO:007168820.014
positive regulation of synaptic transmissionGO:005080640.014
microtubule based processGO:00070172100.014
regulation of secretionGO:00510461940.014
reactive nitrogen species metabolic processGO:200105730.014
response to lipidGO:00339932060.014
regulation of cellular component biogenesisGO:00440872810.014
cellular response to growth factor stimulusGO:00713631970.014
anion transportGO:00068201610.014
associative learningGO:000830610.014
organophosphate biosynthetic processGO:00904071630.014
negative regulation of catabolic processGO:00098951040.014
single organism cell adhesionGO:00986021790.014
salivary gland morphogenesisGO:000743540.014
positive regulation of gtpase activityGO:00435471660.014
cation homeostasisGO:00550801890.014
regulation of i kappab kinase nf kappab signalingGO:00431221620.014
regulation of synaptic plasticityGO:004816730.014
negative regulation of transportGO:00510511760.014
response to fungusGO:000962040.014
negative regulation of cellular catabolic processGO:0031330830.014
cell substrate adhesionGO:00315891320.014
glycoprotein metabolic processGO:00091001100.014
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.014
glial cell migrationGO:000834740.014
regulation of mapk cascadeGO:00434082620.014
cellular chemical homeostasisGO:00550821800.014
negative regulation of muscle contractionGO:004593230.014
protein localization to membraneGO:00726571600.014
regulation of reactive oxygen species biosynthetic processGO:190342630.014
sleepGO:003043120.014
establishment of protein localization to organelleGO:00725941720.014
sulfur compound metabolic processGO:00067901010.014
chromatin modificationGO:00165682980.014
t cell differentiation in thymusGO:003307740.014
cell cycle phase transitionGO:00447701730.014
wnt signaling pathwayGO:00160551560.013
nuclear transportGO:00511691790.013
negative regulation of immune system processGO:00026831360.013
regulation of protein maturationGO:19033171500.013
neurological system processGO:00508771630.013
nucleocytoplasmic transportGO:00069131760.013
cell growthGO:00160491600.013
regulation of multi organism processGO:00439001570.013
morphogenesis of a polarized epitheliumGO:000173830.013
sensory perception of smellGO:000760820.013
response to cytokineGO:00340972320.013
regulation of protein processingGO:00706131500.013
regulation of growthGO:00400081650.013
regulation of dna metabolic processGO:00510521530.013
matingGO:000761810.013
regulation of small gtpase mediated signal transductionGO:00510561560.013
myosin filament organizationGO:003103320.013
myoblast fusionGO:000752010.013
regulation of vesicle mediated transportGO:00606271300.013
regulation of cytoplasmic transportGO:19036491490.013
mitochondrion organizationGO:00070051560.013
immune effector processGO:00022521590.013
photoreceptor cell differentiationGO:004653020.013
response to inorganic substanceGO:00100351270.013
chromatin organizationGO:00063253510.013
rna processingGO:00063962550.013
motor neuron axon guidanceGO:000804520.013
positive regulation of cytokine productionGO:00018191670.013
angiogenesisGO:00015251470.013
regulation of endopeptidase activityGO:00525481700.013
regulation of protein serine threonine kinase activityGO:00719001790.013
rna interferenceGO:001624640.013
epithelium developmentGO:00604292270.013
regulation of cell developmentGO:00602841610.013
thymus developmentGO:004853830.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.013
multi organism cellular processGO:00447641560.013
regulation of secretion by cellGO:19035301770.013
sequestering of metal ionGO:0051238240.013
myeloid cell differentiationGO:00300991170.013
covalent chromatin modificationGO:00165692540.013
regulation of cytoskeleton organizationGO:00514931770.013
response to organic cyclic compoundGO:00140702040.013
protein o linked glycosylation via serineGO:001824230.013
organic hydroxy compound metabolic processGO:19016151470.013
regulation of wnt signaling pathwayGO:00301111230.013
endosomal transportGO:00161971290.012
Fly
negative regulation of cell differentiationGO:00455961710.012
tissue regenerationGO:004224630.012
peptidyl tyrosine phosphorylationGO:00181081700.012
negative regulation of protein maturationGO:19033181420.012
metencephalon developmentGO:002203720.012
response to growth factorGO:00708482050.012
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.012
leukocyte activationGO:00453211640.012
positive regulation of cell motilityGO:20001471770.012
response to axon injuryGO:004867810.012
testosterone biosynthetic processGO:006137020.012
interspecies interaction between organismsGO:00444191560.012
positive regulation of locomotionGO:00400171860.012
mitotic cell cycle phase transitionGO:00447721620.012
regulation of meiotic cell cycleGO:005144540.012
regulation of actin filament based processGO:00329701410.012
cell divisionGO:00513011680.012
positive regulation of cellular component biogenesisGO:00440891580.012
response to nitrogen compoundGO:19016981840.012
hindlimb morphogenesisGO:003513720.012
neural tube formationGO:000184130.012
somitogenesisGO:000175620.012
developmental programmed cell deathGO:001062330.012
regulation of intracellular protein transportGO:00331571230.012
limbic system developmentGO:002176130.012
negative regulation of protein phosphorylationGO:00019331400.012
cell projection assemblyGO:00300311260.012
positive regulation of reactive oxygen species biosynthetic processGO:190342820.012
fatty acid metabolic processGO:00066311150.012
regulation of ras gtpase activityGO:00323181280.012
regulation of neurotransmitter secretionGO:004692830.012
visual behaviorGO:000763220.012
epidermis morphogenesisGO:004873030.012
cellular metal ion homeostasisGO:00068751460.012
stem cell divisionGO:001714520.012
lymphocyte activationGO:00466491330.012
regulation of ion transportGO:00432691890.012
positive regulation of protein transportGO:00512221350.012
primary neural tube formationGO:001402030.012
negative regulation of protein processingGO:00109551420.012
regulation of peptidase activityGO:00525471800.012
response to woundingGO:00096111680.012
tube closureGO:006060630.012
single organismal cell cell adhesionGO:00163371480.012
regulation of apoptotic signaling pathwayGO:20012331750.012
Mouse
neural tube closureGO:000184330.012
peptidyl tyrosine modificationGO:00182121700.012
embryonic placenta developmentGO:000189210.012
regulation of cell growthGO:00015581350.012
regulation of system processGO:00440571010.012
dna repairGO:00062811980.012
divalent metal ion transportGO:00708381520.012
negative regulation of synaptic transmissionGO:005080520.012
cellular cation homeostasisGO:00300031630.012
establishment of planar polarityGO:000173630.012
positive regulation of proteolysisGO:00458621420.012
cellular ion homeostasisGO:00068731680.012
protein localization to nucleusGO:00345041360.012
cellular response to cytokine stimulusGO:00713451810.012
long term memoryGO:000761620.012
response to virusGO:00096151260.012
lung alveolus developmentGO:004828640.011
regulation of defense responseGO:00313471540.011
metal ion homeostasisGO:00550651690.011
divalent inorganic cation transportGO:00725111580.011
somatic stem cell maintenanceGO:003501940.011
monocarboxylic acid biosynthetic processGO:0072330670.011
positive regulation of ras gtpase activityGO:00323201170.011
positive regulation of cell adhesionGO:0045785840.011
positive regulation of reactive oxygen species metabolic processGO:2000379240.011
regulation of cardiac muscle tissue growthGO:005502140.011
specification of organ identityGO:001009230.011
regulation of cysteine type endopeptidase activityGO:20001161270.011
phospholipid metabolic processGO:0006644990.011
positive regulation of neural precursor cell proliferationGO:200017920.011
cerebellum developmentGO:002154920.011
calcium ion transportGO:00068161470.011
regulation of cell morphogenesisGO:00226041530.011
muscle system processGO:0003012810.011
striated muscle adaptationGO:001488840.011
meiosis iGO:000712740.011
regulation of cell activationGO:00508651250.011
meiotic chromosome segregationGO:004513240.011
cellular response to lipidGO:00713961270.011
cardiac muscle contractionGO:0060048340.011
protein importGO:00170381300.011
epithelium migrationGO:00901321190.011
cell differentiation in spinal cordGO:002151510.011
intrinsic apoptotic signaling pathwayGO:00971931270.011
Mouse
positive regulation of cardioblast differentiationGO:005189120.011
negative regulation of proteolysisGO:00458611320.011
regulation of cardioblast differentiationGO:005189040.011
startle responseGO:000196430.011
establishment of tissue polarityGO:000716430.011
blood vessel developmentGO:00015681720.011
prostate gland developmentGO:003085030.011
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiationGO:000325730.011
protein homooligomerizationGO:00512601000.011
sequestering of calcium ionGO:0051208170.011
regulation of odontogenesisGO:004248140.011
establishment of protein localization to membraneGO:00901501210.011
regulation of reactive oxygen species metabolic processGO:2000377410.011
ossificationGO:00015031210.011
protein autophosphorylationGO:00467771230.011
post embryonic organ developmentGO:004856910.011
circadian sleep wake cycleGO:004274520.011
blood circulationGO:00080151130.011
defense response to fungusGO:005083240.011
rab protein signal transductionGO:003248240.011
negative regulation of cell cycle processGO:00109481210.011
defense response to other organismGO:00985421290.011
glycerolipid metabolic processGO:00464861070.011
symbiosis encompassing mutualism through parasitismGO:00444031560.011
glycoprotein biosynthetic processGO:0009101910.011
regulation of protein complex assemblyGO:00432541470.011
protein acylationGO:00435431380.011
negative regulation of transferase activityGO:00513481240.011
follicle stimulating hormone secretionGO:004688430.011
organic anion transportGO:00157111030.011

PLEKHF1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.037
disease of metabolismDOID:00146672950.032
inherited metabolic disorderDOID:6552420.026
sensory system diseaseDOID:00501552030.022
nervous system diseaseDOID:8634310.022
myopathyDOID:4231040.021
muscle tissue diseaseDOID:661130.021
muscular diseaseDOID:00800001140.021
central nervous system diseaseDOID:3311860.019
eye and adnexa diseaseDOID:14921500.018
eye diseaseDOID:56141490.018
cancerDOID:1621670.017
organ system cancerDOID:00506861640.017
disease of cellular proliferationDOID:145661740.017
immune system diseaseDOID:29141550.016
connective tissue diseaseDOID:651090.015
bone diseaseDOID:0080001880.014
neurodegenerative diseaseDOID:12891020.014
retinal diseaseDOID:56791180.013
cardiovascular system diseaseDOID:12871060.011
brain diseaseDOID:936730.011