Homo sapiens

84 known processes

APEX1

APEX nuclease (multifunctional DNA repair enzyme) 1

(Aliases: APE1,APX,HAP1,APEX,REF1,APEN,APE)

APEX1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
oogenesisGO:004847720.855
ribonucleoside monophosphate metabolic processGO:00091611870.609
nucleoside monophosphate metabolic processGO:00091231910.588
purine ribonucleoside monophosphate metabolic processGO:00091671860.569
purine ribonucleoside metabolic processGO:00461284370.481
negative regulation of apoptotic processGO:00430663160.459
Zebrafish
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.441
purine ribonucleoside triphosphate metabolic processGO:00092054110.428
atp metabolic processGO:00460341760.387
ribonucleoside monophosphate catabolic processGO:00091581580.372
determination of adult lifespanGO:000834020.357
apoptotic signaling pathwayGO:00971902680.357
base excision repairGO:0006284210.342
Worm
gmp metabolic processGO:004603740.335
cellular response to cytokine stimulusGO:00713451810.304
female gamete generationGO:000729220.289
positive regulation of developmental processGO:00510943140.273
purine nucleoside triphosphate metabolic processGO:00091444120.273
positive regulation of apoptotic processGO:00430652460.265
cellular macromolecular complex assemblyGO:00346223240.250
nucleoside triphosphate catabolic processGO:00091433940.238
ribose phosphate biosynthetic processGO:0046390820.231
response to cytokineGO:00340972320.227
atp catabolic processGO:00062001570.205
covalent chromatin modificationGO:00165692540.199
purine nucleoside monophosphate catabolic processGO:00091281580.174
dna packagingGO:0006323770.166
ribonucleoside triphosphate catabolic processGO:00092033910.159
cytoplasmic transportGO:00164823790.158
regulation of atp metabolic processGO:1903578290.157
purine nucleoside monophosphate metabolic processGO:00091261860.157
cellular amino acid metabolic processGO:00065201160.146
nervous system developmentGO:00073992930.142
ribonucleoside triphosphate metabolic processGO:00091994120.139
mrna metabolic processGO:00160711750.135
negative regulation of programmed cell deathGO:00430693210.135
Zebrafish
translationGO:00064121320.135
regulation of cellular response to stressGO:00801352440.132
negative regulation of cell deathGO:00605483450.131
Zebrafish
dna conformation changeGO:00711031130.127
nucleoside triphosphate metabolic processGO:00091414220.127
negative regulation of atpase activityGO:003278050.125
histone modificationGO:00165702510.120
dna repairGO:00062811980.118
negative regulation of mitotic cell cycle phase transitionGO:1901991850.111
purine nucleoside triphosphate catabolic processGO:00091463920.110
post embryonic developmentGO:000979120.108
Worm
regulation of oxidative phosphorylationGO:000208230.108
positive regulation of immune system processGO:00026842830.107
regulation of dna bindingGO:0051101370.106
purine containing compound catabolic processGO:00725234110.103
protein dna complex assemblyGO:0065004640.101
neuron differentiationGO:00301821380.099
cellular amine metabolic processGO:0044106410.094
cation homeostasisGO:00550801890.086
organophosphate catabolic processGO:00464344300.085
negative regulation of cell cycleGO:00457861930.085
chromatin organizationGO:00063253510.083
guanosine containing compound metabolic processGO:19010682440.081
hematopoietic or lymphoid organ developmentGO:00485341860.073
purine containing compound biosynthetic processGO:0072522880.073
regulation of feeding behaviorGO:006025930.071
purine ribonucleoside catabolic processGO:00461303980.068
protein dna complex subunit organizationGO:0071824800.067
cellular response to dna damage stimulusGO:00069743790.066
nucleoside monophosphate catabolic processGO:00091251590.066
growthGO:00400072020.065
immune system developmentGO:00025201950.065
transmembrane transportGO:00550853990.064
purine ribonucleoside monophosphate catabolic processGO:00091691580.063
regulation of nucleoside metabolic processGO:00091182090.063
nucleotide biosynthetic processGO:00091651090.063
multi organism cellular processGO:00447641560.063
purine ribonucleoside triphosphate catabolic processGO:00092073910.063
regulation of bindingGO:00510981110.061
positive regulation of cellular amine metabolic processGO:003324070.061
nucleic acid phosphodiester bond hydrolysisGO:00903051020.060
rrna modificationGO:000015420.058
nucleoside catabolic processGO:00091644080.057
cell type specific apoptotic processGO:00972851250.057
nucleosome assemblyGO:0006334500.056
single organism reproductive processGO:0044702980.056
positive regulation of defense responseGO:0031349870.055
regulation of growthGO:00400081650.055
hemopoiesisGO:00300971800.053
response to other organismGO:00517072610.053
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.052
response to abiotic stimulusGO:00096283360.052
nucleotide catabolic processGO:00091664080.050
columnar cuboidal epithelial cell differentiationGO:0002065140.049
response to virusGO:00096151260.048
chromatin modificationGO:00165682980.046
nucleoside phosphate biosynthetic processGO:19012931090.046
gland developmentGO:0048732480.046
defense responseGO:00069523150.045
glycosyl compound catabolic processGO:19016584130.045
multicellular organismal agingGO:001025930.045
cellular cation homeostasisGO:00300031630.045
cell growthGO:00160491600.043
regulation of epithelial cell proliferationGO:00506781130.043
positive regulation of protein transportGO:00512221350.042
cell morphogenesisGO:00009022960.042
mitochondrial membrane organizationGO:0007006400.042
reproductive system developmentGO:0061458560.041
nucleoside phosphate catabolic processGO:19012924120.041
response to oxygen containing compoundGO:19017003690.041
organonitrogen compound biosynthetic processGO:19015662000.040
purine nucleotide biosynthetic processGO:0006164840.040
protein maturationGO:00516042330.039
protein tetramerizationGO:0051262470.039
positive regulation of cellular amino acid metabolic processGO:004576430.039
regulation of cell differentiationGO:00455953930.039
regulation of nucleotide metabolic processGO:00061402690.039
embryo developmentGO:00097901230.039
Zebrafish Worm
chemotaxisGO:00069351570.038
purine ribonucleotide biosynthetic processGO:0009152790.038
negative regulation of cell proliferationGO:00082852280.038
double strand break repairGO:00063021010.038
trna metabolic processGO:0006399350.038
purine nucleoside catabolic processGO:00061523980.038
system processGO:00030083490.037
Zebrafish
negative regulation of cellular catabolic processGO:0031330830.037
circulatory system developmentGO:00723592620.037
Zebrafish
carbohydrate derivative biosynthetic processGO:19011372070.036
secretion by cellGO:00329402260.036
mitotic nuclear divisionGO:00070671190.036
meiotic chromosome segregationGO:004513240.036
dna replicationGO:00062601160.035
negative regulation of catabolic processGO:00098951040.035
generation of neuronsGO:00486991520.034
peptidyl serine phosphorylationGO:00181051010.034
purine nucleotide catabolic processGO:00061954050.034
cytokine productionGO:00018162470.034
mitochondrion organizationGO:00070051560.033
ribonucleoprotein complex biogenesisGO:00226131160.033
positive regulation of cell differentiationGO:00455972110.032
viral processGO:00160321460.032
regulation of cellular amino acid metabolic processGO:000652160.032
negative regulation of protein metabolic processGO:00512483910.031
regulation of purine nucleotide metabolic processGO:19005422640.030
negative regulation of cell growthGO:0030308830.030
positive regulation of transportGO:00510503360.030
ion homeostasisGO:00508012300.030
regulation of behaviorGO:0050795820.030
regulation of intracellular transportGO:00323861950.029
negative regulation of apoptotic signaling pathwayGO:2001234970.029
histone arginine methylationGO:003496960.029
chromatin assemblyGO:0031497610.029
regulation of nuclease activityGO:0032069110.028
cellular component morphogenesisGO:00329893140.028
ribonucleoprotein complex subunit organizationGO:0071826810.028
negative regulation of cell cycle processGO:00109481210.028
protein processingGO:00164852260.027
behaviorGO:00076101120.027
purine ribonucleotide catabolic processGO:00091544040.027
mitotic cell cycleGO:00002783260.026
translational initiationGO:0006413480.026
epithelial cell proliferationGO:00506731280.026
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.026
rna processingGO:00063962550.026
cell developmentGO:00484683280.026
developmental process involved in reproductionGO:0003006660.025
amine metabolic processGO:0009308440.025
cellular ketone metabolic processGO:0042180800.024
immune effector processGO:00022521590.024
ribonucleoside catabolic processGO:00424544060.024
response to lipidGO:00339932060.024
membrane organizationGO:00610242920.024
regulation of multi organism processGO:00439001570.024
viral life cycleGO:00190581320.024
cellular macromolecule catabolic processGO:00442653800.024
sex differentiationGO:0007548450.024
regulation of cellular ketone metabolic processGO:0010565500.023
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.023
cellular homeostasisGO:00197251960.023
Mouse
positive regulation of programmed cell deathGO:00430682490.023
protein localization to membraneGO:00726571600.023
negative regulation of cellular component organizationGO:00511292350.023
single organism membrane organizationGO:00448022680.023
cell activationGO:00017752130.023
cell part morphogenesisGO:00329901370.022
regulation of protein maturationGO:19033171500.022
cellular chemical homeostasisGO:00550821800.022
nuclear transportGO:00511691790.022
nucleosome organizationGO:0034728660.022
symbiosis encompassing mutualism through parasitismGO:00444031560.021
cell projection organizationGO:00300302520.021
positive regulation of immune responseGO:00507781590.021
intracellular protein transportGO:00068862700.021
negative regulation of cell cycle phase transitionGO:1901988890.021
mitotic cell cycle phase transitionGO:00447721620.021
negative regulation of catalytic activityGO:00430863350.021
establishment of protein localization to membraneGO:00901501210.020
negative regulation of developmental processGO:00510932470.020
embryonic eye morphogenesisGO:004804820.020
response to external biotic stimulusGO:00432072610.020
positive regulation of cellular component organizationGO:00511303760.020
neurological system processGO:00508771630.020
response to inorganic substanceGO:00100351270.020
leukocyte proliferationGO:0070661740.020
response to drugGO:0042493810.020
secretionGO:00469032540.020
cellular calcium ion homeostasisGO:00068741170.019
regulation of cell growthGO:00015581350.019
regulation of protein transportGO:00512232130.019
negative regulation of cellular protein metabolic processGO:00322693530.019
negative regulation of protein modification processGO:00314002000.019
dna catabolic processGO:0006308490.018
regulation of transferase activityGO:00513383550.018
histone exchangeGO:004348630.018
regulation of proteolysisGO:00301622930.018
response to acid chemicalGO:0001101660.018
response to biotic stimulusGO:00096072760.018
regulation of apoptotic signaling pathwayGO:20012331750.018
response to transforming growth factor betaGO:0071559940.018
positive regulation of proteolysisGO:00458621420.018
regulation of mitochondrion organizationGO:0010821540.018
negative regulation of mitotic cell cycleGO:00459301020.018
cation transmembrane transportGO:00986552380.018
osteoblast differentiationGO:0001649920.017
developmental programmed cell deathGO:001062330.017
rna splicingGO:00083801310.017
mammary gland developmentGO:0030879170.017
metal ion transportGO:00300012720.017
transcription from rna polymerase i promoterGO:0006360110.017
innate immune responseGO:00450871780.017
establishment of protein localization to organelleGO:00725941720.017
negative regulation of growthGO:0045926970.016
negative regulation of phosphate metabolic processGO:00459362670.016
cell projection morphogenesisGO:00488581290.016
reproductive processGO:00224141060.016
neurogenesisGO:00220081690.016
cell cycle phase transitionGO:00447701730.016
dna duplex unwindingGO:0032508300.016
negative regulation of phosphorus metabolic processGO:00105632670.016
protein targetingGO:00066051870.016
extrinsic apoptotic signaling pathwayGO:00971911190.016
regulation of myeloid cell differentiationGO:0045637810.016
mammary gland morphogenesisGO:006044320.016
regulation of kinase activityGO:00435493140.016
negative regulation of epithelial cell proliferationGO:0050680480.016
glycoprotein metabolic processGO:00091001100.016
response to endoplasmic reticulum stressGO:0034976490.016
cellular response to abiotic stimulusGO:00712141170.016
negative regulation of transportGO:00510511760.016
negative regulation of atp catabolic processGO:190329050.016
development of primary sexual characteristicsGO:0045137350.015
mrna processingGO:00063971330.015
positive regulation of intracellular transportGO:00323881040.015
immune responseGO:00069553070.015
cell morphogenesis involved in differentiationGO:00009041440.015
regulation of viral genome replicationGO:0045069480.015
negative regulation of multi organism processGO:0043901920.015
dna demethylationGO:0080111120.015
cellular component disassemblyGO:0022411920.015
chromatin assembly or disassemblyGO:0006333780.014
ossificationGO:00015031210.014
cellular response to acid chemicalGO:0071229440.014
regulation of gene silencingGO:0060968240.014
transforming growth factor beta receptor signaling pathwayGO:0007179760.014
cellular ion homeostasisGO:00068731680.014
intrinsic apoptotic signaling pathwayGO:00971931270.014
protein alkylationGO:0008213740.014
regulation of neuron apoptotic processGO:0043523350.014
regulation of nucleotide catabolic processGO:00308112050.014
positive regulation of cell deathGO:00109422630.014
mitotic cell cycle processGO:19030472860.013
central nervous system developmentGO:00074171230.013
multi organism reproductive processGO:0044703540.013
regulation of cell cycle processGO:00105642660.013
segmentationGO:003528240.013
positive regulation of cell proliferationGO:00082843010.013
dna modificationGO:0006304270.013
sexual reproductionGO:0019953370.013
rna modificationGO:0009451270.013
enzyme linked receptor protein signaling pathwayGO:00071673030.013
ncrna metabolic processGO:00346601080.013
regulation of protein complex assemblyGO:00432541470.013
lymphocyte proliferationGO:0046651700.013
single organism carbohydrate metabolic processGO:00447231930.013
reproductive structure developmentGO:0048608550.012
regulation of dna metabolic processGO:00510521530.012
positive regulation of cell developmentGO:0010720920.012
ribonucleotide biosynthetic processGO:0009260810.012
tissue morphogenesisGO:0048729960.012
Zebrafish
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377890.012
protein importGO:00170381300.012
negative regulation of organelle organizationGO:00106391260.012
cellular response to endogenous stimulusGO:00714953360.012
neuron projection developmentGO:00311751060.012
intrinsic apoptotic signaling pathway in response to osmotic stressGO:000862720.012
neuron apoptotic processGO:0051402390.012
cellular divalent inorganic cation homeostasisGO:00725031280.012
oocyte developmentGO:004859910.011
single organism cellular localizationGO:19025803320.011
negative regulation of nucleotide catabolic processGO:0030812160.011
intracellular receptor signaling pathwayGO:00305221040.011
regulation of defense responseGO:00313471540.011
nuclear exportGO:0051168690.011
cell cycle checkpointGO:00000751170.011
developmental growthGO:0048589480.011
protein localization to organelleGO:00333652800.011
chemical homeostasisGO:00488783060.011
protein stabilizationGO:0050821640.011
gtp metabolic processGO:00460392390.011
negative regulation of oxidative stress induced cell deathGO:1903202170.011
regulation of establishment of protein localizationGO:00702012420.011
ribonucleoside monophosphate biosynthetic processGO:0009156170.011
nucleoside monophosphate biosynthetic processGO:0009124190.011
amino acid activationGO:0043038120.011
regulation of cellular amine metabolic processGO:0033238110.011
immune response regulating cell surface receptor signaling pathwayGO:0002768510.011
excretionGO:000758890.011
viral genome replicationGO:0019079500.011
cellular protein complex assemblyGO:00436231880.011
protein autoprocessingGO:001654040.011
regulation of organ morphogenesisGO:2000027240.011
regulation of cellular component biogenesisGO:00440872810.011
regulation of nervous system developmentGO:0051960880.011
mrna splicing via spliceosomeGO:0000398890.011
organelle fissionGO:00482851490.011
nucleocytoplasmic transportGO:00069131760.011
ion transmembrane transportGO:00342203380.010
mononuclear cell proliferationGO:0032943710.010
cellular metal ion homeostasisGO:00068751460.010
cellular response to oxidative stressGO:0034599850.010
cellular response to transforming growth factor beta stimulusGO:0071560940.010
trna aminoacylationGO:0043039120.010
positive regulation of hydrolase activityGO:00513453310.010

APEX1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
central nervous system diseaseDOID:3311860.063
nervous system diseaseDOID:8634310.063
acquired metabolic diseaseDOID:0060158580.024
disease of metabolismDOID:00146672950.024
disease of cellular proliferationDOID:145661740.023
cancerDOID:1621670.023
organ system cancerDOID:00506861640.011
disease of mental healthDOID:150700.010