Homo sapiens

178 known processes

SMAD4

SMAD family member 4

(Aliases: DPC4,JIP,MADH4)

SMAD4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781251.000
regulation of transforming growth factor beta receptor signaling pathwayGO:0017015481.000
bmp signaling pathwayGO:0030509491.000
transforming growth factor beta receptor signaling pathwayGO:0007179761.000
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101451.000
Human
somatic stem cell maintenanceGO:003501941.000
Fly
negative regulation of transcription from rna polymerase ii promoterGO:00001222811.000
Human Worm
regulation of activin receptor signaling pathwayGO:0032925141.000
Human
cellular response to transforming growth factor beta stimulusGO:0071560941.000
cellular response to endogenous stimulusGO:00714953361.000
negative regulation of cell differentiationGO:00455961711.000
Fly
chromatin organizationGO:00063253511.000
cellular response to growth factor stimulusGO:00713631971.000
negative regulation of bmp signaling pathwayGO:0030514171.000
Human
regulation of canonical wnt signaling pathwayGO:0060828881.000
Human
response to transforming growth factor betaGO:0071559941.000
stem cell differentiationGO:0048863930.999
Human Mouse Fly
enzyme linked receptor protein signaling pathwayGO:00071673030.999
neuron fate commitmentGO:004866320.999
Mouse
regulation of ketone biosynthetic processGO:001056670.999
positive regulation of proteolysisGO:00458621420.999
Human
response to growth factorGO:00708482050.999
positive regulation of osteoblast differentiationGO:0045669230.998
negative regulation of transforming growth factor beta receptor signaling pathwayGO:0030512280.998
Human
canonical wnt signaling pathwayGO:00600701160.998
Human
protein modification by small protein conjugationGO:00324463420.998
Human
response to external biotic stimulusGO:00432072610.998
Human
regulation of cellular response to growth factor stimulusGO:0090287760.998
digestive system developmentGO:0055123750.998
Mouse
regulation of mrna export from nucleusGO:001079330.998
regulation of cellular component biogenesisGO:00440872810.998
Human Fly
regulation of osteoblast differentiationGO:0045667380.998
chromatin assembly or disassemblyGO:0006333780.997
regulation of pathway restricted smad protein phosphorylationGO:0060393340.997
Human Mouse
negative regulation of gliogenesisGO:001401430.997
regulation of bmp signaling pathwayGO:0030510270.996
mesenchymal cell developmentGO:0014031500.996
Human Mouse
receptor catabolic processGO:0032801110.995
regulation of wnt signaling pathwayGO:00301111230.995
Human
embryonic morphogenesisGO:0048598850.995
Mouse
negative regulation of immune system processGO:00026831360.995
stem cell maintenanceGO:0019827190.995
Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.995
positive regulation of cytoplasmic transportGO:1903651820.994
Human Mouse
negative regulation of developmental processGO:00510932470.994
Worm Fly
zygotic specification of dorsal ventral axisGO:000735220.994
Human
negative regulation of cell proliferationGO:00082852280.994
Human Mouse
negative regulation of glial cell proliferationGO:006025320.994
development involved in symbiotic interactionGO:004411110.993
response to biotic stimulusGO:00096072760.993
Human
defense responseGO:00069523150.992
negative regulation of cellular response to growth factor stimulusGO:0090288410.992
Human
connective tissue developmentGO:0061448390.992
cell fate determinationGO:000170930.990
response to other organismGO:00517072610.989
Human
intracellular receptor signaling pathwayGO:00305221040.989
regulation of nodal signaling pathwayGO:190010710.988
Human
mesenchyme developmentGO:0060485590.988
Human Mouse
negative regulation of smad protein complex assemblyGO:001099140.987
Human
nervous system developmentGO:00073992930.987
Mouse Fly
negative regulation of multi organism processGO:0043901920.987
epithelial to mesenchymal transitionGO:0001837480.986
Human Mouse
positive regulation of developmental processGO:00510943140.985
Human Mouse Worm Fly
regulation of schwann cell proliferationGO:001062410.984
positive regulation of cell differentiationGO:00455972110.983
Human Mouse
negative regulation of sodium ion transmembrane transportGO:190230620.982
mesenchymal cell differentiationGO:0048762520.982
Human Mouse
negative regulation of sodium ion transmembrane transporter activityGO:200065020.980
transcription initiation from rna polymerase ii promoterGO:0006367270.979
modification dependent macromolecule catabolic processGO:00436322120.978
Human
positive regulation of nucleocytoplasmic transportGO:0046824540.977
Human Mouse
chromatin modificationGO:00165682980.977
tube morphogenesisGO:0035239950.976
Mouse
regulation of ossificationGO:0030278580.975
regulation of cytokine productionGO:00018172320.975
lens morphogenesis in camera type eyeGO:000208920.974
polyprenol biosynthetic processGO:001609410.973
protein ubiquitinationGO:00165673140.973
Human
positive regulation of transportGO:00510503360.972
Human Mouse
positive regulation of cellular protein catabolic processGO:1903364370.971
Human
defense response to other organismGO:00985421290.970
multi organism cellular processGO:00447641560.970
Human
protein targetingGO:00066051870.970
Human Mouse
proteolysis involved in cellular protein catabolic processGO:00516032440.970
Human
stem cell developmentGO:0048864690.970
Human Mouse Fly
regulation of multi organism processGO:00439001570.967
positive regulation of proteasomal protein catabolic processGO:1901800350.966
Human
regulation of nodal signaling pathway involved in determination of lateral mesoderm left right asymmetryGO:190017510.966
Human
ossificationGO:00015031210.964
wnt signaling pathwayGO:00160551560.963
Human
endodermal cell fate specificationGO:000171440.963
digestive tract morphogenesisGO:0048546560.960
Mouse
protein deacylationGO:0035601390.959
positive regulation of cellular component organizationGO:00511303760.958
Human Mouse Fly
positive regulation of protein localization to nucleusGO:1900182480.957
Human Mouse
negative regulation of schwann cell proliferationGO:001062610.957
dna templated transcription initiationGO:0006352350.957
regulation of nodal signaling pathway involved in determination of left right asymmetryGO:190014510.956
Human
positive regulation of hydrolase activityGO:00513453310.956
Human
regulation of protein transportGO:00512232130.954
Human Mouse
nucleocytoplasmic transportGO:00069131760.953
Human Mouse
heart morphogenesisGO:0003007480.953
Mouse
cytokine productionGO:00018162470.951
regulation of cell cycleGO:00517263930.951
Human
trna transportGO:005103110.949
intracellular steroid hormone receptor signaling pathwayGO:0030518610.949
mesoderm developmentGO:0007498140.948
Human Mouse
positive regulation of catabolic processGO:00098963100.948
Human Worm
nuclear transportGO:00511691790.946
Human Mouse
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052350.946
Human
ribosomal large subunit export from nucleusGO:000005530.943
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.942
Human
trna export from nucleusGO:000640910.941
posttranscriptional regulation of gene expressionGO:00106082130.940
Human
cytoplasmic transportGO:00164823790.939
Human Mouse
formation of primary germ layerGO:0001704420.939
positive regulation of peptidase activityGO:0010952880.938
Human
embryo developmentGO:00097901230.937
Human Mouse
lens development in camera type eyeGO:000208820.936
negative regulation of defense responseGO:0031348470.935
regulation of cell differentiationGO:00455953930.931
Human Mouse Fly
positive regulation of protein catabolic processGO:0045732750.931
Human Worm
regulation of myeloid cell differentiationGO:0045637810.930
reproductive structure developmentGO:0048608550.929
potassium ion transmembrane transportGO:0071805600.926
regulation of protein complex assemblyGO:00432541470.926
Human
negative regulation of cell growthGO:0030308830.921
protein localization to organelleGO:00333652800.921
Human Mouse
cellular macromolecule catabolic processGO:00442653800.920
Human
regulation of glial cell proliferationGO:006025140.919
regulation of cytoplasmic transportGO:19036491490.917
Human Mouse
covalent chromatin modificationGO:00165692540.916
organ morphogenesisGO:00098871470.915
Mouse Fly
dissemination or transmission of organism from other organism involved in symbiotic interactionGO:005182110.912
modification dependent protein catabolic processGO:00199412090.909
Human
dissemination or transmission of symbiont from hostGO:004400710.906
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulusGO:190152220.906
protein importGO:00170381300.904
Human Mouse
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetryGO:190016410.902
Human
neuron differentiationGO:00301821380.900
Mouse Fly
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.900
Human
positive regulation of cell proliferationGO:00082843010.900
Mouse
positive regulation of transforming growth factor beta receptor signaling pathwayGO:0030511120.900
regulation of nucleocytoplasmic transportGO:0046822980.898
Human Mouse
negative regulation of cell deathGO:00605483450.894
Human Mouse
regulation of sequence specific dna binding transcription factor activityGO:00510902110.891
Human
negative regulation of transcription from rna polymerase ii promoter in response to uv induced dna damageGO:001076810.891
regulation of defense responseGO:00313471540.888
osteoblast differentiationGO:0001649920.888
positive regulation of transcription factor import into nucleusGO:0042993250.887
Human
regulation of intracellular transportGO:00323861950.886
Human Mouse
heart developmentGO:0007507950.884
Mouse
interspecies interaction between organismsGO:00444191560.883
Human
endodermal cell fate commitmentGO:000171140.882
evasion or tolerance of host defensesGO:004441520.880
Human
skeletal system developmentGO:0001501790.867
transmission of virusGO:001908910.867
negative regulation of protein metabolic processGO:00512483910.861
symbiosis encompassing mutualism through parasitismGO:00444031560.860
Human
progesterone receptor signaling pathwayGO:005084730.858
ubiquitin dependent endocytosisGO:007008610.857
response to lipidGO:00339932060.857
Human
positive regulation of bmp signaling pathwayGO:003051390.855
reproductive processGO:00224141060.855
Worm Fly
cellular response to dna damage stimulusGO:00069743790.852
establishment of protein localization to organelleGO:00725941720.852
Human Mouse
regulation of cofactor metabolic processGO:005119330.851
polyprenol metabolic processGO:001609330.850
positive regulation of intracellular transportGO:00323881040.848
Human Mouse
positive regulation of cellular catabolic processGO:00313312840.846
Human
viral processGO:00160321460.845
Human
regulation of stem cell differentiationGO:2000736560.843
Human Mouse
neurogenesisGO:00220081690.843
Mouse Fly
proteasomal protein catabolic processGO:00104981760.837
Human
negative regulation of intracellular steroid hormone receptor signaling pathwayGO:0033144180.836
bone developmentGO:0060348260.834
cell fate commitmentGO:0045165270.833
Mouse
regulation of proteolysisGO:00301622930.830
Human
neural crest cell developmentGO:001403230.829
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.829
Human
regulation of anatomical structure morphogenesisGO:00226032860.825
Human Mouse
protein dna complex assemblyGO:0065004640.822
regulation of proteasomal protein catabolic processGO:0061136870.818
Human
embryonic organ morphogenesisGO:0048562240.817
intracellular protein transportGO:00068862700.817
Human Mouse
growthGO:00400072020.813
regulation of transcription from rna polymerase ii promoter in response to uv induced dna damageGO:001076710.808
ubiquitin dependent protein catabolic processGO:00065112060.806
Human
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436300.804
Human
neural tube formationGO:000184130.798
cell morphogenesisGO:00009022960.798
Human Mouse Fly
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left right asymmetryGO:190022410.796
Human
negative regulation of sodium ion transportGO:001076630.794
regulation of establishment of protein localizationGO:00702012420.794
Human Mouse
activin receptor signaling pathwayGO:0032924240.787
Human
positive regulation of developmental growthGO:0048639160.783
Worm Fly
single organism cellular localizationGO:19025803320.781
Human Mouse
mapk cascadeGO:00001652880.776
protein targeting to nucleusGO:00447441040.775
Human Mouse
cell developmentGO:00484683280.774
Human Mouse Fly
anatomical structure formation involved in morphogenesisGO:00486462840.767
Mouse
negative regulation of transcription by competitive promoter bindingGO:001094480.765
Human
negative regulation of apoptotic processGO:00430663160.763
Human
protein k29 linked ubiquitinationGO:003551940.757
blood vessel developmentGO:00015681720.754
transforming growth factor beta productionGO:0071604140.754
regulation of cysteine type endopeptidase activityGO:20001161270.749
Human
endocardial cushion developmentGO:000319730.747
Mouse
histone modificationGO:00165702510.746
positive regulation of lipid metabolic processGO:0045834500.729
positive regulation of mapk cascadeGO:00434101900.728
isoprenoid metabolic processGO:0006720390.726
negative regulation of catalytic activityGO:00430863350.721
Human
evasion or tolerance of defenses of other organism involved in symbiotic interactionGO:005183420.720
Human
generation of neuronsGO:00486991520.716
Mouse Fly
regulation of multivesicular body sizeGO:001079610.713
regulation of peptidase activityGO:00525471800.705
Human
regulation of cell morphogenesisGO:00226041530.703
Human Mouse
positive regulation of cellular component biogenesisGO:00440891580.695
Fly
cellular potassium ion transportGO:0071804600.694
regulation of endopeptidase activityGO:00525481700.685
Human
protein catabolic processGO:00301633250.684
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.682
Human
negative regulation of multicellular organismal processGO:00512413170.680
Worm
regulation of epithelial to mesenchymal transitionGO:0010717370.677
Human Mouse
kidney developmentGO:0001822530.670
Mouse
negative regulation of wnt signaling pathwayGO:0030178690.669
cellular component morphogenesisGO:00329893140.664
Human Mouse Fly
positive regulation of protein transportGO:00512221350.662
Human Mouse
signal transduction by phosphorylationGO:00230142970.658
hard palate developmentGO:006002210.656
catenin import into nucleusGO:0035411180.647
Human
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.647
single organism nuclear importGO:19025931040.647
Human Mouse
eye developmentGO:0001654420.647
negative regulation of immune responseGO:0050777400.641
regulation of protein ubiquitinationGO:0031396950.639
Human
ubiquitin dependent smad protein catabolic processGO:003057940.636
embryonic camera type eye morphogenesisGO:004859620.636
immune responseGO:00069553070.635
Human
digestive tract developmentGO:0048565750.628
Mouse
nose developmentGO:004358420.627
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.626
Human
regulation of cellular protein catabolic processGO:1903362960.621
Human
cellular response to radiationGO:0071478650.617
negative regulation of protein modification processGO:00314002000.614
Human
immune system developmentGO:00025201950.614
ribosomal subunit export from nucleusGO:000005440.610
regulation of cartilage developmentGO:0061035120.605
morphogenesis of embryonic epitheliumGO:001633140.599
regulation of viral transcriptionGO:0046782340.596
positive regulation of wnt signaling pathwayGO:0030177540.596
Human
cardiovascular system developmentGO:00723582620.590
Mouse
extrinsic apoptotic signaling pathwayGO:00971911190.590
Human
cellular response to abiotic stimulusGO:00712141170.586
oogenesisGO:004847720.586
Fly
trophectodermal cell differentiationGO:000182930.584
cell type specific apoptotic processGO:00972851250.584
metal ion transportGO:00300012720.579
ameboidal type cell migrationGO:00016671350.578
endoderm formationGO:0001706330.574
epithelium developmentGO:00604292270.572
Mouse Fly
regulation of cell developmentGO:00602841610.570
Human Mouse
cell morphogenesis involved in differentiationGO:00009041440.567
Human Mouse Fly
lysosomal transportGO:0007041330.565
response to radiationGO:00093141510.565
potassium ion transportGO:0006813620.565
positive regulation of epithelial to mesenchymal transitionGO:0010718220.564
Human Mouse
negative regulation of phosphate metabolic processGO:00459362670.563
Human
embryonic organ developmentGO:0048568360.553
cell cell signalingGO:00072671550.553
Fly
determination of adult lifespanGO:000834020.553
negative regulation of androgen receptor activityGO:200082420.553
regulation of stress activated mapk cascadeGO:0032872840.551
negative regulation of protein modification by small protein conjugation or removalGO:1903321410.548
Human
ion homeostasisGO:00508012300.545
system processGO:00030083490.539
regulation of viral processGO:00507921030.538
cellular protein catabolic processGO:00442572610.534
Human
multicellular organismal agingGO:001025930.533
negative regulation of cellular protein metabolic processGO:00322693530.532
Human
response to drugGO:0042493810.528
response to steroid hormoneGO:0048545800.527
regulation of nervous system developmentGO:0051960880.524
Fly
neuron projection developmentGO:00311751060.523
Mouse Fly
cellular ketone metabolic processGO:0042180800.521
negative regulation of ion transmembrane transportGO:0034766260.519
embryonic epithelial tube formationGO:000183840.518
fat cell differentiationGO:0045444320.514
Human
morphogenesis of an epitheliumGO:0002009600.509
Mouse
hemopoiesisGO:00300971800.509
embryonic eye morphogenesisGO:004804820.504
vacuolar transportGO:0007034340.501
chordate embryonic developmentGO:0043009340.499
Mouse
regulation of protein import into nucleusGO:0042306780.493
Human Mouse
regulation of dna bindingGO:0051101370.489
cellular response to lipidGO:00713961270.489
blastocyst formationGO:000182530.488
common partner smad protein phosphorylationGO:000718230.487
Human
tube developmentGO:00352951250.480
Mouse
maintenance of protein locationGO:0045185570.478
endosome transport via multivesicular body sorting pathwayGO:003250930.477
quinone metabolic processGO:1901661180.465
protein sumoylationGO:0016925250.465
development of primary sexual characteristicsGO:0045137350.463
regulation of protein catabolic processGO:00421761550.462
response to metal ionGO:0010038840.462
negative regulation of immune effector processGO:0002698380.458
interaction with hostGO:0051701420.455
Human
nodal signaling pathway involved in determination of left right asymmetryGO:003810710.452
Human
regulation of intracellular protein transportGO:00331571230.449
Human Mouse
positive regulation of canonical wnt signaling pathwayGO:0090263330.449
Human
regulation of mapk cascadeGO:00434082620.448
viral life cycleGO:00190581320.447
peptidyl threonine phosphorylationGO:0018107410.446
Human
anterior posterior axis specificationGO:000994820.443
Mouse
regulation of chromatin organizationGO:1902275560.440
smad protein signal transductionGO:0060395100.437
blastocyst developmentGO:000182430.436
establishment of ribosome localizationGO:003375340.436
positive regulation of cell cycleGO:00457871400.434
gastrulationGO:0007369510.428
Mouse
regulation of bindingGO:00510981110.422
Mouse
pharynx developmentGO:006046510.419
viral gene expressionGO:0019080350.414
coenzyme biosynthetic processGO:0009108240.410
regulation of immune responseGO:00507762010.410
dolichol biosynthetic processGO:001940810.408
regulation of potassium ion transmembrane transportGO:1901379200.401
cell adhesionGO:00071553250.399
Human
negative regulation of pathway restricted smad protein phosphorylationGO:0060394110.399
Human
atrioventricular valve developmentGO:000317130.399
Mouse
female gamete generationGO:000729220.398
Fly
pattern specification processGO:0007389430.397
Human Mouse Fly
cell fate specificationGO:000170880.396
rrna containing ribonucleoprotein complex export from nucleusGO:007142840.391
regulation of cell morphogenesis involved in differentiationGO:0010769830.390
Human Mouse
regulation of response to external stimulusGO:00321012220.385
vasculature developmentGO:00019441810.385
positive regulation of phosphorylationGO:00423273940.384
Mouse
viral release from host cellGO:0019076210.383
regulation of potassium ion transmembrane transporter activityGO:1901016160.383
chemical homeostasisGO:00488783060.382
skeletal system morphogenesisGO:0048705240.381
regulation of innate immune responseGO:0045088970.380
single organism cell adhesionGO:00986021790.379
Human
positive regulation of mesoderm developmentGO:200038220.377
Human
regulation of neuron differentiationGO:0045664700.375
negative regulation of protein ubiquitinationGO:0031397350.374
Human
gland developmentGO:0048732480.372
Mouse
positive regulation of neuron differentiationGO:0045666400.370
regulation of defense response to virusGO:0050688330.367
positive regulation of immune system processGO:00026842830.366
regulation of leukocyte differentiationGO:1902105610.366
cellular macromolecular complex assemblyGO:00346223240.366
sensory organ developmentGO:0007423520.366
regulation of response to biotic stimulusGO:0002831550.363
protein autoubiquitinationGO:0051865370.360
positive regulation of cysteine type endopeptidase activityGO:2001056790.359
Human
developmental process involved in reproductionGO:0003006660.358
Worm Fly
regulation of endothelial cell differentiationGO:004560140.357
myeloid cell differentiationGO:00300991170.355
somitogenesisGO:000175620.355
Mouse
dolichol metabolic processGO:001934830.349
endocrine system developmentGO:0035270260.349
defense response to virusGO:0051607710.346
response to virusGO:00096151260.338
negative regulation of neurogenesisGO:0050768260.337
regulation of transcription initiation from rna polymerase ii promoterGO:006026080.337
muscle structure developmentGO:0061061980.334
negative regulation of cellular component organizationGO:00511292350.330
Human
i kappab kinase nf kappab signalingGO:00072491660.329
regulation of cellular ketone metabolic processGO:0010565500.329
sex differentiationGO:0007548450.328
Worm
determination of bilateral symmetryGO:0009855150.325
Human
cartilage developmentGO:0051216310.325
reproductive system developmentGO:0061458560.325
regulation of growthGO:00400081650.324
regulation of mitotic cell cycle phase transitionGO:19019901180.321
endoderm developmentGO:0007492330.320
Mouse
inositol lipid mediated signalingGO:0048017550.317
single organism reproductive processGO:0044702980.313
Fly
cellular response to steroid hormone stimulusGO:0071383370.312
embryo development ending in birth or egg hatchingGO:0009792340.312
Mouse
mitochondrion organizationGO:00070051560.312
regulation of developmental growthGO:0048638300.308
Worm Fly
cellular response to cytokine stimulusGO:00713451810.308
positive regulation of apoptotic processGO:00430652460.306
Human
mesoderm morphogenesisGO:0048332110.305
negative regulation of bindingGO:0051100570.305
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiationGO:000325730.304
axis specificationGO:0009798120.302
Human Mouse Fly
regulation of cell growthGO:00015581350.301
cell fate commitment involved in formation of primary germ layerGO:006079560.296
negative regulation of cell developmentGO:0010721480.294
regulation of histone modificationGO:0031056470.293
lymphocyte proliferationGO:0046651700.291
appendage morphogenesisGO:0035107160.291
Fly
cellular response to ionizing radiationGO:0071479320.287
gene silencingGO:0016458490.287
receptor metabolic processGO:0043112810.286
positive regulation of catenin import into nucleusGO:003541390.285
Human
cardiac endothelial cell differentiationGO:000334820.284
Mouse
endosomal transportGO:00161971290.282
regulation of cellular response to stressGO:00801352440.276
negative regulation of response to external stimulusGO:0032102830.272
regulation of neural precursor cell proliferationGO:200017740.271
embryonic heart tube morphogenesisGO:000314380.271
response to host defensesGO:005220020.271
Human
embryonic placenta developmentGO:000189210.268
renal system developmentGO:0072001630.267
Mouse
rna polymerase ii transcriptional preinitiation complex assemblyGO:005112340.264
developmental growthGO:0048589480.263
Mouse Worm Fly
regulation of epithelial cell migrationGO:0010632930.263
autophagyGO:0006914880.263
negative regulation of transcription initiation from rna polymerase ii promoterGO:006063330.262
protein localization to nucleusGO:00345041360.260
Human Mouse
regulation of immune effector processGO:0002697910.258
regulation of nucleotide metabolic processGO:00061402690.257
negative regulation of androgen receptor signaling pathwayGO:0060766100.256
endodermal cell differentiationGO:0035987310.255
protein import into nucleusGO:00066061040.254
Human Mouse
regionalizationGO:0003002290.253
Human Mouse Fly
histone deacetylationGO:0016575320.251
negative regulation of sequence specific dna binding transcription factor activityGO:0043433890.251
Human
ketone biosynthetic processGO:0042181170.250
modulation by host of symbiont transcriptionGO:0052472200.249
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetryGO:190009410.248
Human
positive regulation of chondrocyte differentiationGO:003233240.247
regulation of protein modification by small protein conjugation or removalGO:19033201070.247
Human
mesonephros developmentGO:0001823170.246
Mouse
positive regulation of intracellular protein transportGO:0090316760.244
Human Mouse
maintenance of location in cellGO:0051651620.244
gonad developmentGO:0008406340.241
positive regulation of programmed cell deathGO:00430682490.240
Human
isoprenoid biosynthetic processGO:000829990.238
negative regulation of dna bindingGO:0043392180.237
response to fungusGO:000962040.237
hematopoietic or lymphoid organ developmentGO:00485341860.236
positive regulation of neurogenesisGO:0050769490.231
notch signaling pathwayGO:0007219310.231
adherens junction assemblyGO:0034333340.228
Human
coenzyme metabolic processGO:0006732650.228
ribonucleoprotein complex biogenesisGO:00226131160.227
quinone biosynthetic processGO:190166360.226
innate immune responseGO:00450871780.225
peptidyl threonine modificationGO:0018210450.225
Human
late endosome to vacuole transportGO:004532420.224
modification by host of symbiont morphology or physiologyGO:0051851260.223
monocarboxylic acid metabolic processGO:00327871850.223
regulation of meiotic cell cycleGO:005144540.223
inorganic cation transmembrane transportGO:00986621940.222
response to organic cyclic compoundGO:00140702040.220
Human
regulation of neurogenesisGO:0050767820.220
regulation of dna templated transcription initiationGO:200014290.220
positive regulation of cell morphogenesis involved in differentiationGO:0010770500.219
Human Mouse
hindbrain developmentGO:003090230.219
regulation of fatty acid biosynthetic processGO:004230490.219
negative regulation of viral processGO:0048525660.218
cellular response to bmp stimulusGO:007177380.217
ras protein signal transductionGO:0007265730.216
anterior posterior pattern specificationGO:000995290.216
Mouse
cell growthGO:00160491600.215
microtubule based processGO:00070172100.215
sodium ion transmembrane transportGO:0035725590.214
positive regulation of fatty acid metabolic processGO:0045923110.212
regulation of chromosome organizationGO:00330441030.212
cell part morphogenesisGO:00329901370.208
Mouse Fly
positive regulation of jnk cascadeGO:0046330520.207
regulation of epithelial cell differentiationGO:0030856240.206
regulation of fat cell differentiationGO:0045598230.205
protein oligomerizationGO:00512591730.204
protein dna complex subunit organizationGO:0071824800.204
response to light stimulusGO:0009416870.203
blood vessel morphogenesisGO:00485141620.201
nuclear importGO:00511701060.201
Human Mouse
regulation of gene silencingGO:0060968240.201
protein deacetylationGO:0006476380.199
epithelium migrationGO:00901321190.199
cell cycle g1 s phase transitionGO:0044843800.198
activation of cysteine type endopeptidase activityGO:0097202570.198
Human
cell morphogenesis involved in neuron differentiationGO:0048667440.197
Mouse Fly
cell cycle arrestGO:0007050710.195
Human

SMAD4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
thyroid carcinomaDOID:3963130.836
papillary thyroid carcinomaDOID:396960.836
endocrine gland cancerDOID:170260.836
thyroid cancerDOID:1781130.836
cancerDOID:1621670.836
disease of cellular proliferationDOID:145661740.836
organ system cancerDOID:00506861640.836
bone diseaseDOID:0080001880.263
musculoskeletal system diseaseDOID:172230.263
connective tissue diseaseDOID:651090.263
bone development diseaseDOID:0080006550.206