Homo sapiens

0 known processes

PIK3R4

phosphoinositide-3-kinase, regulatory subunit 4

(Aliases: MGC102700,VPS15,p150)

PIK3R4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
ras protein signal transductionGO:0007265730.144
rab protein signal transductionGO:003248240.130
cytoplasmic transportGO:00164823790.087
Yeast
positive regulation of nucleoside metabolic processGO:00459791860.084
post embryonic developmentGO:000979120.081
purine containing compound catabolic processGO:00725234110.080
endomembrane system organizationGO:00102561960.077
nucleoside catabolic processGO:00091644080.073
regulation of purine nucleotide metabolic processGO:19005422640.072
phosphatidylinositol 3 phosphate biosynthetic processGO:003609230.069
small gtpase mediated signal transductionGO:0007264780.066
regulation of protein localizationGO:00328802960.065
lipid metabolic processGO:00066293810.064
positive regulation of cellular catabolic processGO:00313312840.062
regulation of nucleotide metabolic processGO:00061402690.059
gtp catabolic processGO:00061842370.059
regulation of cellular amino acid metabolic processGO:000652160.058
purine ribonucleoside triphosphate catabolic processGO:00092073910.057
multicellular organismal agingGO:001025930.056
purine ribonucleoside metabolic processGO:00461284370.055
positive regulation of purine nucleotide catabolic processGO:00331231850.055
regulation of cellular amine metabolic processGO:0033238110.055
regulation of nucleotide catabolic processGO:00308112050.054
lipid biosynthetic processGO:00086101770.053
cellular lipid metabolic processGO:00442553030.053
purine nucleotide catabolic processGO:00061954050.053
positive regulation of nucleotide catabolic processGO:00308131850.052
macroautophagyGO:0016236390.052
Yeast
glycerolipid biosynthetic processGO:0045017510.051
regulation of gtpase activityGO:00430871800.050
lipid modificationGO:0030258840.050
positive regulation of purine nucleotide metabolic processGO:19005442270.050
ribonucleoside triphosphate metabolic processGO:00091994120.049
ion transmembrane transportGO:00342203380.049
guanosine containing compound catabolic processGO:19010692390.049
regulation of kinase activityGO:00435493140.048
female gamete generationGO:000729220.048
ribonucleotide catabolic processGO:00092614050.048
cellular amine metabolic processGO:0044106410.048
positive regulation of hydrolase activityGO:00513453310.046
cellular amino acid metabolic processGO:00065201160.045
regulation of secretionGO:00510461940.045
cellular response to nutrient levelsGO:0031669690.044
Yeast
oogenesisGO:004847720.044
glycerolipid metabolic processGO:00464861070.043
locomotory behaviorGO:000762610.043
glycosyl compound catabolic processGO:19016584130.043
regulation of ras protein signal transductionGO:00465781550.043
regulation of gtp catabolic processGO:00331241800.043
regulation of rab gtpase activityGO:0032313390.042
regulation of cellular ketone metabolic processGO:0010565500.042
amine metabolic processGO:0009308440.041
positive regulation of gtpase activityGO:00435471660.040
protein maturationGO:00516042330.040
positive regulation of nucleotide metabolic processGO:00459812300.040
vesicle mediated transportGO:00161923710.040
organophosphate catabolic processGO:00464344300.040
cellular ketone metabolic processGO:0042180800.040
endosomal transportGO:00161971290.039
Yeast
glycerophospholipid metabolic processGO:0006650840.039
cell divisionGO:00513011680.039
organophosphate biosynthetic processGO:00904071630.039
single organism membrane organizationGO:00448022680.038
positive regulation of rab gtpase activityGO:0032851390.038
transmembrane transportGO:00550853990.038
regulation of protein kinase activityGO:00458592890.037
defense responseGO:00069523150.037
regulation of establishment of protein localizationGO:00702012420.037
nucleoside triphosphate catabolic processGO:00091433940.037
regulation of protein transportGO:00512232130.036
positive regulation of catabolic processGO:00098963100.036
negative regulation of protein metabolic processGO:00512483910.036
nucleoside triphosphate metabolic processGO:00091414220.036
negative regulation of phosphorus metabolic processGO:00105632670.036
regulation of purine nucleotide catabolic processGO:00331212050.035
negative regulation of phosphate metabolic processGO:00459362670.035
nucleoside phosphate catabolic processGO:19012924120.035
autophagyGO:0006914880.035
Yeast
purine nucleoside catabolic processGO:00061523980.035
guanosine containing compound metabolic processGO:19010682440.034
signal transduction by phosphorylationGO:00230142970.034
regulation of small gtpase mediated signal transductionGO:00510561560.033
purine ribonucleoside catabolic processGO:00461303980.033
membrane organizationGO:00610242920.033
positive regulation of gtp catabolic processGO:00331261660.033
rho protein signal transductionGO:0007266260.032
negative regulation of catalytic activityGO:00430863350.032
positive regulation of cellular amine metabolic processGO:003324070.032
peroxisome organizationGO:0007031280.032
Yeast
negative regulation of cellular protein metabolic processGO:00322693530.032
cell developmentGO:00484683280.032
regulation of nucleoside metabolic processGO:00091182090.032
positive regulation of cellular amino acid metabolic processGO:004576430.031
cytokinesisGO:0000910960.031
regulation of rab protein signal transductionGO:0032483390.031
determination of adult lifespanGO:000834020.031
positive regulation of phosphorylationGO:00423273940.031
neuromuscular junction developmentGO:000752830.031
early endosome to late endosome transportGO:0045022210.030
cellular response to external stimulusGO:00714961110.030
Yeast
hindbrain developmentGO:003090230.029
regulation of transferase activityGO:00513383550.029
purine ribonucleoside triphosphate metabolic processGO:00092054110.029
cation transmembrane transportGO:00986552380.029
system processGO:00030083490.029
segmentationGO:003528240.028
purine ribonucleotide catabolic processGO:00091544040.028
ribonucleoside catabolic processGO:00424544060.028
ribonucleoside triphosphate catabolic processGO:00092033910.028
regulation of mapk cascadeGO:00434082620.028
phospholipid metabolic processGO:0006644990.028
chemical homeostasisGO:00488783060.027
cellular response to starvationGO:0009267580.027
Yeast
single organism cellular localizationGO:19025803320.027
Yeast
regulation of cell cycleGO:00517263930.027
ion homeostasisGO:00508012300.027
protein catabolic processGO:00301633250.027
anterior posterior axis specificationGO:000994820.027
response to organonitrogen compoundGO:00102431560.026
metal ion transportGO:00300012720.026
regulation of meiotic cell cycleGO:005144540.026
secretion by cellGO:00329402260.026
inorganic ion transmembrane transportGO:00986602310.026
regulation of ras gtpase activityGO:00323181280.026
regulation of secretion by cellGO:19035301770.026
vacuole organizationGO:0007033440.026
Yeast
cell morphogenesisGO:00009022960.026
photoreceptor cell differentiationGO:004653020.026
microtubule cytoskeleton organizationGO:00002261760.026
negative regulation of intracellular signal transductionGO:19025321830.025
intracellular protein transportGO:00068862700.025
Yeast
monovalent inorganic cation transportGO:00156721280.025
oocyte differentiationGO:000999420.025
purine nucleoside triphosphate catabolic processGO:00091463920.025
negative regulation of cell deathGO:00605483450.025
regulation of cell differentiationGO:00455953930.025
negative regulation of programmed cell deathGO:00430693210.024
mapk cascadeGO:00001652880.024
gtp metabolic processGO:00460392390.024
motor neuron axon guidanceGO:000804520.024
blastoderm segmentationGO:000735020.024
oocyte developmentGO:004859910.024
purine nucleoside triphosphate metabolic processGO:00091444120.023
positive regulation of cellular component organizationGO:00511303760.023
negative regulation of protein modification processGO:00314002000.023
positive regulation of dna templated transcription elongationGO:0032786180.023
Yeast
nucleotide catabolic processGO:00091664080.023
dephosphorylationGO:00163112090.023
positive regulation of protein phosphorylationGO:00019343130.023
organelle assemblyGO:00709251760.023
microtubule based processGO:00070172100.023
negative regulation of phosphorylationGO:00423261740.023
embryonic epithelial tube formationGO:000183840.023
response to extracellular stimulusGO:0009991850.023
Yeast
innate immune responseGO:00450871780.023
nervous system developmentGO:00073992930.023
regenerationGO:003109940.023
phosphatidylinositol metabolic processGO:0046488530.023
positive regulation of protein kinase activityGO:00458601900.023
protein ubiquitinationGO:00165673140.022
regulation of protein secretionGO:0050708860.022
anatomical structure formation involved in morphogenesisGO:00486462840.022
regulation of response to external stimulusGO:00321012220.021
peroxisome degradationGO:003024210.021
Yeast
protein localization to membraneGO:00726571600.021
response to nitrogen compoundGO:19016981840.021
negative regulation of cellular component organizationGO:00511292350.021
regulation of proteolysisGO:00301622930.021
circadian behaviorGO:004851220.021
immune responseGO:00069553070.021
negative regulation of cell proliferationGO:00082852280.021
positive regulation of organelle organizationGO:00106381950.021
regulation of cellular response to stressGO:00801352440.021
mitotic cell cycleGO:00002783260.021
positive regulation of apoptotic processGO:00430652460.021
cell projection organizationGO:00300302520.021
endosome organizationGO:0007032200.021
cellular component morphogenesisGO:00329893140.020
cell projection morphogenesisGO:00488581290.020
secretionGO:00469032540.020
positive regulation of transferase activityGO:00513472270.020
interleukin 13 secretionGO:007261120.020
anion transportGO:00068201610.020
neural tube formationGO:000184130.020
negative regulation of cellular amino acid metabolic processGO:004576320.020
memoryGO:000761330.020
inorganic cation transmembrane transportGO:00986621940.020
posttranscriptional regulation of gene expressionGO:00106082130.020
actin filament based processGO:00300292240.020
negative regulation of apoptotic processGO:00430663160.020
tripartite regional subdivisionGO:000735120.019
associative learningGO:000830610.019
cation transportGO:00068123310.019
rhythmic behaviorGO:000762220.019
phosphatidylinositol mediated signalingGO:0048015550.019
protein targetingGO:00066051870.019
Yeast
cardiac muscle cell contractionGO:008600340.019
regulation of anatomical structure morphogenesisGO:00226032860.019
anterior posterior axis specification embryoGO:000859520.019
response to starvationGO:0042594590.019
Yeast
cellular response to extracellular stimulusGO:0031668720.019
Yeast
morphogenesis of embryonic epitheliumGO:001633140.019
growthGO:00400072020.019
Worm
mitotic cell cycle processGO:19030472860.019
positive regulation of cell proliferationGO:00082843010.019
negative regulation of cell cycleGO:00457861930.018
generation of neuronsGO:00486991520.018
spermatid differentiationGO:004851540.018
primary neural tube formationGO:001402030.018
positive regulation of synaptic transmissionGO:005080640.018
melanin metabolic processGO:000658210.018
cation homeostasisGO:00550801890.018
negative regulation of developmental processGO:00510932470.018
protein localization to organelleGO:00333652800.018
Yeast
negative regulation of hydrolase activityGO:00513461820.018
cellular macromolecular complex assemblyGO:00346223240.018
protein secretionGO:0009306980.018
positive regulation of developmental processGO:00510943140.018
neuron differentiationGO:00301821380.018
cellular response to cytokine stimulusGO:00713451810.018
regulation of protein serine threonine kinase activityGO:00719001790.018
response to oxygen containing compoundGO:19017003690.018
positive regulation of ras gtpase activityGO:00323201170.018
positive regulation of cell deathGO:00109422630.018
response to abiotic stimulusGO:00096283360.017
neuroblast proliferationGO:000740540.017
peripheral nervous system developmentGO:000742220.017
negative regulation of cellular amine metabolic processGO:003323930.017
regulation of growthGO:00400081650.017
phospholipid biosynthetic processGO:0008654440.017
oxidation reduction processGO:00551143960.017
cell fate determinationGO:000170930.017
response to biotic stimulusGO:00096072760.017
positive regulation of kinase activityGO:00336742040.017
regulation of cell cycle processGO:00105642660.017
mitotic cell cycle phase transitionGO:00447721620.017
carbohydrate metabolic processGO:00059752070.017
spermatid developmentGO:000728640.017
metencephalon developmentGO:002203720.017
regulation of synaptic plasticityGO:004816730.017
positive regulation of programmed cell deathGO:00430682490.017
response to nutrient levelsGO:0031667810.017
Yeast
regulation of mitotic cell cycleGO:00073461890.017
neurogenesisGO:00220081690.016
autophagic vacuole assemblyGO:0000045190.016
negative regulation of protein phosphorylationGO:00019331400.016
regulation of immune responseGO:00507762010.016
organelle fissionGO:00482851490.016
negative regulation of multicellular organismal processGO:00512413170.016
positive regulation of transportGO:00510503360.016
nerve developmentGO:002167540.016
regulation of cellular component biogenesisGO:00440872810.016
negative regulation of transferase activityGO:00513481240.016
adult locomotory behaviorGO:000834410.016
cellular homeostasisGO:00197251960.016
endocytosisGO:00068971590.016
histone modificationGO:00165702510.016
reactive oxygen species biosynthetic processGO:190340940.016
cellular chemical homeostasisGO:00550821800.016
regulation of cell morphogenesisGO:00226041530.015
compound eye developmentGO:004874910.015
rna interferenceGO:001624640.015
cellular response to oxygen containing compoundGO:19017012760.015
ribonucleoside monophosphate metabolic processGO:00091611870.015
protein processingGO:00164852260.015
regulation of peptidase activityGO:00525471800.015
proteolysis involved in cellular protein catabolic processGO:00516032440.015
cellular macromolecule catabolic processGO:00442653800.015
post embryonic organ developmentGO:004856910.015
embryo developmentGO:00097901230.015
regulation of cysteine type endopeptidase activityGO:20001161270.015
cell part morphogenesisGO:00329901370.015
cellular protein catabolic processGO:00442572610.015
cell cycle phase transitionGO:00447701730.015
nucleocytoplasmic transportGO:00069131760.015
protein acylationGO:00435431380.015
establishment or maintenance of microtubule cytoskeleton polarityGO:003095120.015
cellular cation homeostasisGO:00300031630.015
carbohydrate derivative biosynthetic processGO:19011372070.015
positive regulation of meiotic cell cycleGO:005144620.015
organonitrogen compound biosynthetic processGO:19015662000.015
neurological system processGO:00508771630.015
matingGO:000761810.015
establishment of protein localization to membraneGO:00901501210.015
regulation of intracellular transportGO:00323861950.014
cellular response to endogenous stimulusGO:00714953360.014
cell type specific apoptotic processGO:00972851250.014
regulation of vesicle mediated transportGO:00606271300.014
regulation of membrane potentialGO:0042391950.014
somitogenesisGO:000175620.014
internal protein amino acid acetylationGO:00064751010.014
stem cell divisionGO:001714520.014
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.014
neural tube closureGO:000184330.014
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.014
response to cytokineGO:00340972320.014
regulation of protein processingGO:00706131500.014
visual behaviorGO:000763220.014
cellular metal ion homeostasisGO:00068751460.014
establishment or maintenance of cytoskeleton polarityGO:003095230.014
cellular response to dna damage stimulusGO:00069743790.014
circulatory system developmentGO:00723592620.014
toxin transportGO:190199840.014
regulation of endopeptidase activityGO:00525481700.014
maintenance of locationGO:00512351120.014
Yeast Worm
purine nucleoside monophosphate metabolic processGO:00091261860.014
tube closureGO:006060630.014
somatic muscle developmentGO:000752510.014
release of cytoplasmic sequestered nf kappabGO:000858840.014
single organism carbohydrate metabolic processGO:00447231930.014
translationGO:00064121320.014
mitochondrion organizationGO:00070051560.014
sensory perception of smellGO:000760820.014
negative regulation of protein processingGO:00109551420.014
atp metabolic processGO:00460341760.014
plasma membrane organizationGO:00070091150.013
negative regulation of kinase activityGO:00336731060.013
cell migration involved in gastrulationGO:004207410.013
biological adhesionGO:00226103310.013
actin cytoskeleton organizationGO:00300362070.013
response to external biotic stimulusGO:00432072610.013
multicellular organismal response to stressGO:003355510.013
neurotransmitter secretionGO:000726940.013
male meiosisGO:000714010.013
regulation of protein maturationGO:19033171500.013
cellular divalent inorganic cation homeostasisGO:00725031280.013
cell cell signalingGO:00072671550.013
anion transmembrane transportGO:0098656760.013
limbic system developmentGO:002176130.013
positive regulation of immune system processGO:00026842830.013
nuclear transportGO:00511691790.013
phosphatidylinositol biosynthetic processGO:0006661250.013
nucleoside monophosphate metabolic processGO:00091231910.013
positive regulation of interleukin 5 productionGO:003275430.013
cell activationGO:00017752130.013
immune effector processGO:00022521590.013
membrane hyperpolarizationGO:006008110.013
response to axon injuryGO:004867810.013
meiosis iGO:000712740.013
regulation of feeding behaviorGO:006025930.013
enzyme linked receptor protein signaling pathwayGO:00071673030.013
monocarboxylic acid metabolic processGO:00327871850.013
regulation of cytoskeleton organizationGO:00514931770.013
cell growthGO:00160491600.012
response to fungusGO:000962040.012
small molecule biosynthetic processGO:00442831570.012
g protein coupled receptor signaling pathwayGO:00071862070.012
cell morphogenesis involved in differentiationGO:00009041440.012
nitrogen compound transportGO:00717051910.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
visual learningGO:000854210.012
cell projection assemblyGO:00300311260.012
regulation of locomotionGO:00400123290.012
negative regulation of transportGO:00510511760.012
sodium ion transmembrane transportGO:0035725590.012
cellular ion homeostasisGO:00068731680.012
cytokine productionGO:00018162470.012
protein dephosphorylationGO:0006470810.012
eye photoreceptor cell differentiationGO:000175420.012
reactive nitrogen species metabolic processGO:200105730.012
cellular response to organic cyclic compoundGO:00714071270.012
proteasomal protein catabolic processGO:00104981760.012
regulation of cell developmentGO:00602841610.012
covalent chromatin modificationGO:00165692540.012
tissue regenerationGO:004224630.012
organ morphogenesisGO:00098871470.012
negative regulation of protein maturationGO:19033181420.012
apoptotic signaling pathwayGO:00971902680.012
response to other organismGO:00517072610.012
positive regulation of immune responseGO:00507781590.012
negative regulation of peptidase activityGO:0010466910.012
protein modification by small protein conjugationGO:00324463420.012
peptidyl tyrosine dephosphorylationGO:0035335360.012
positive regulation of cellular component movementGO:00512721810.012
glycerophospholipid biosynthetic processGO:0046474400.012
establishment or maintenance of bipolar cell polarityGO:006124520.012
calcium ion homeostasisGO:00550741220.012
morphogenesis of a polarized epitheliumGO:000173830.012
cerebellum developmentGO:002154920.012
somatic stem cell divisionGO:004810310.012
response to organic cyclic compoundGO:00140702040.012
cellular component disassemblyGO:0022411920.012
intracellular mrna localizationGO:000829810.012
regulation of protein catabolic processGO:00421761550.012
rna processingGO:00063962550.012
regulation of cytoplasmic transportGO:19036491490.012
regulation of meiosisGO:004002030.012
actin filament based movementGO:0030048170.011
purine ribonucleoside monophosphate metabolic processGO:00091671860.011
protein localization to plasma membraneGO:0072659930.011
leukocyte activationGO:00453211640.011
regulation of actin filament based processGO:00329701410.011
negative regulation of protein kinase activityGO:0006469980.011
regulation of cell divisionGO:00513021160.011
meiotic chromosome segregationGO:004513240.011
establishment of protein localization to organelleGO:00725941720.011
Yeast
regulation of cell activationGO:00508651250.011
establishment of planar polarityGO:000173630.011
regulation of rho protein signal transductionGO:0035023790.011
rac protein signal transductionGO:0016601120.011
neuron developmentGO:00486661130.011
neuronal stem cell divisionGO:003644510.011
modification dependent protein catabolic processGO:00199412090.011
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.011
regulation of mitotic cell cycle phase transitionGO:19019901180.011
cranial nerve developmentGO:002154540.011
endosome to lysosome transportGO:0008333210.011
sensory perception of painGO:001923340.011
divalent inorganic cation homeostasisGO:00725071360.011
cellular response to organonitrogen compoundGO:00714171240.011
actin mediated cell contractionGO:0070252120.011
regulation of cell cycle phase transitionGO:19019871260.011
regulation of dephosphorylationGO:0035303960.011
regulation of endocytosisGO:0030100720.011
regulation of sequence specific dna binding transcription factor activityGO:00510902110.011
reactive oxygen species metabolic processGO:0072593750.011
modification dependent macromolecule catabolic processGO:00436322120.011
regulation of cellular component sizeGO:0032535820.011
cellular response to growth factor stimulusGO:00713631970.011
inner ear morphogenesisGO:004247240.011
peptidyl serine modificationGO:00182091060.011
regulation of transcription from rna polymerase ii promoter mitoticGO:004602110.011
positive regulation of mapk cascadeGO:00434101900.011
negative regulation of immune system processGO:00026831360.011
sensory perceptionGO:00076001030.011
regulation of anatomical structure sizeGO:00900661010.011
peptidyl lysine modificationGO:00182051440.011
positive regulation of cell differentiationGO:00455972110.011
organ formationGO:004864530.011
regulation of neural precursor cell proliferationGO:200017740.011
regulation of ion transportGO:00432691890.011
sleepGO:003043120.011
transcription elongation from rna polymerase ii promoterGO:0006368180.011
Yeast
embryonic placenta developmentGO:000189210.011
regulation of cell projection organizationGO:00313441070.010
regulation of transmembrane transportGO:00347621390.010
regulation of i kappab kinase nf kappab signalingGO:00431221620.010
nuclear divisionGO:00002801280.010
positive regulation of secretionGO:00510471160.010
positive regulation of cellular component biogenesisGO:00440891580.010
myeloid cell differentiationGO:00300991170.010
regulation of myeloid leukocyte mediated immunityGO:000288640.010
protein autophosphorylationGO:00467771230.010
potassium ion transmembrane transportGO:0071805600.010
response to woundingGO:00096111680.010
regulation of homeostatic processGO:00328441210.010
behavioral defense responseGO:000220900.010
regulation of multi organism processGO:00439001570.010
ubiquitin dependent protein catabolic processGO:00065112060.010
mitotic nuclear divisionGO:00070671190.010
establishment of tissue polarityGO:000716430.010
cellular response to lipidGO:00713961270.010
chemotaxisGO:00069351570.010
spinal cord developmentGO:002151040.010
regulation of ion transmembrane transportGO:00347651320.010
response to radiationGO:00093141510.010
reproductive processGO:00224141060.010
regulation of cellular component movementGO:00512703340.010
central nervous system developmentGO:00074171230.010
engulfment of apoptotic cellGO:004365220.010
positive regulation of transcription from rna polymerase ii promoter during mitosisGO:004602210.010
protein acetylationGO:00064731160.010
peptidyl tyrosine phosphorylationGO:00181081700.010
chromatin organizationGO:00063253510.010
chromatin modificationGO:00165682980.010
carboxylic acid biosynthetic processGO:0046394970.010
regulation of rho gtpase activityGO:0032319660.010
positive regulation of reactive oxygen species biosynthetic processGO:190342820.010
sequestering of metal ionGO:0051238240.010
synaptic transmission cholinergicGO:000727120.010
nuclear migrationGO:000709710.010
regulation of intracellular protein transportGO:00331571230.010

PIK3R4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
central nervous system diseaseDOID:3311860.031
nervous system diseaseDOID:8634310.031
disease of metabolismDOID:00146672950.030
musculoskeletal system diseaseDOID:172230.022
sensory system diseaseDOID:00501552030.022
inherited metabolic disorderDOID:6552420.021
eye and adnexa diseaseDOID:14921500.020
eye diseaseDOID:56141490.020
neurodegenerative diseaseDOID:12891020.019
retinal diseaseDOID:56791180.016
disease of cellular proliferationDOID:145661740.015
cancerDOID:1621670.015
myopathyDOID:4231040.014
muscular diseaseDOID:00800001140.014
muscle tissue diseaseDOID:661130.014
immune system diseaseDOID:29141550.013
connective tissue diseaseDOID:651090.013
retinal degenerationDOID:8466890.013
cardiovascular system diseaseDOID:12871060.012
organ system cancerDOID:00506861640.012
bone diseaseDOID:0080001880.011