Homo sapiens

21 known processes

HLA-DMA

major histocompatibility complex, class II, DM alpha

(Aliases: DMA,RING6,D6S222E,HLADM)

HLA-DMA biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dendritic cell antigen processing and presentationGO:000246811.000
peptide antigen assembly with mhc class ii protein complexGO:000250341.000
polysaccharide assembly with mhc class ii protein complexGO:000250620.999
Human
peptide antigen assembly with mhc protein complexGO:000250140.999
antigen processing and presentation of peptide antigenGO:0048002180.998
antigen processing and presentation of peptide antigen via mhc class iiGO:0002495110.998
antigen processing and presentation of peptide or polysaccharide antigen via mhc class iiGO:0002504120.998
positive regulation of myeloid leukocyte cytokine production involved in immune responseGO:006108110.996
mhc protein complex assemblyGO:000239640.995
regulation of interleukin 10 secretionGO:200117940.992
antigen processing and presentationGO:0019882330.990
mhc class ii protein complex assemblyGO:000239940.990
negative regulation of antigen processing and presentationGO:000257850.970
Human
regulation of t cell proliferationGO:0042129420.955
protein carbohydrate complex subunit organizationGO:007182320.953
Human
cytokine productionGO:00018162470.926
positive regulation of lymphocyte proliferationGO:0050671460.905
regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cellGO:200118820.905
protein carbohydrate complex assemblyGO:006500620.904
Human
lymphocyte proliferationGO:0046651700.898
de novo protein foldingGO:000645820.889
Mouse
mononuclear cell proliferationGO:0032943710.881
regulation of lymphocyte proliferationGO:0050670640.865
peptide secretionGO:0002790510.853
t helper 1 type immune responseGO:004208880.844
cellular protein complex assemblyGO:00436231880.844
negative regulation of antigen processing and presentation of peptide antigen via mhc class iiGO:000258720.835
Human
inflammatory response to antigenic stimulusGO:000243740.804
regulation of leukocyte proliferationGO:0070663670.794
regulation of mononuclear cell proliferationGO:0032944650.776
leukocyte proliferationGO:0070661740.767
detection of biotic stimulusGO:0009595210.755
regulation of interferon gamma productionGO:0032649360.750
regulation of lymphocyte activationGO:00512491030.742
Mouse
cellular macromolecular complex assemblyGO:00346223240.727
peptide transportGO:0015833740.722
humoral immune responseGO:0006959490.718
Mouse
regulation of cell activationGO:00508651250.712
Mouse
t cell proliferationGO:0042098450.690
regulation of t cell activationGO:0050863770.687
Mouse
cell activationGO:00017752130.672
Mouse
immune responseGO:00069553070.668
Mouse
t cell activationGO:0042110990.663
Mouse
positive regulation of leukocyte activationGO:0002696800.647
Mouse
antigen processing and presentation of exogenous peptide antigenGO:000247840.646
Mouse
lymphocyte activationGO:00466491330.644
Mouse
positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:003577430.633
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via mhc class iiGO:000258130.629
Human
positive regulation of lymphocyte activationGO:0051251730.626
Mouse
regulation of immune effector processGO:0002697910.594
negative regulation of inflammatory response to antigenic stimulusGO:000286220.586
regulation of cytokine productionGO:00018172320.579
positive regulation of immune responseGO:00507781590.565
Mouse
regulation of defense responseGO:00313471540.548
interferon gamma productionGO:0032609390.547
positive regulation of cell activationGO:0050867810.544
Mouse
response to glucoseGO:0009749190.542
innate immune responseGO:00450871780.540
regulation of leukocyte activationGO:00026941150.540
Mouse
leukocyte activationGO:00453211640.536
Mouse
defense responseGO:00069523150.528
positive regulation of insulin secretionGO:0032024100.521
detection of chemical stimulus involved in sensory perceptionGO:0050907330.509
response to hexoseGO:0009746200.507
negative regulation of t cell activationGO:0050868180.494
negative regulation of antigen processing and presentation of peptide antigenGO:000258430.480
Human
antigen processing and presentation of exogenous antigenGO:001988440.473
Mouse
negative regulation of leukocyte differentiationGO:1902106240.455
regulation of immune responseGO:00507762010.453
Mouse
positive regulation of immune system processGO:00026842830.453
Mouse
negative regulation of defense responseGO:0031348470.441
leukocyte mediated immunityGO:0002443590.436
Mouse
positive regulation of t cell proliferationGO:0042102330.412
positive regulation of hormone secretionGO:0046887250.412
humoral immune response mediated by circulating immunoglobulinGO:000245550.411
negative regulation of multicellular organismal processGO:00512413170.408
cellular homeostasisGO:00197251960.403
cellular response to interferon gammaGO:0071346240.398
secretion by cellGO:00329402260.386
regulation of antigen processing and presentationGO:000257760.380
Human
positive regulation of leukocyte proliferationGO:0070665480.377
negative regulation of immune system processGO:00026831360.367
Human
positive regulation of lymphocyte differentiationGO:0045621130.352
Mouse
cytokine secretionGO:0050663640.351
positive regulation of mononuclear cell proliferationGO:0032946470.345
positive regulation of t cell activationGO:0050870540.330
Mouse
response to oxygen containing compoundGO:19017003690.328
positive regulation of t cell differentiationGO:0045582110.325
Mouse
regulation of response to woundingGO:19030341010.322
positive regulation of secretion by cellGO:19035321080.314
hormone secretionGO:0046879650.300
positive regulation of peptide secretionGO:0002793150.296
nitrogen compound transportGO:00717051910.293
regulation of cell migrationGO:00303342890.292
interleukin 10 productionGO:0032613170.282
t cell selectionGO:004505840.275
Mouse
amide transportGO:0042886760.271
detection of stimulusGO:0051606850.260
cellular response to ammonium ionGO:007124240.240
positive regulation of peptide hormone secretionGO:0090277150.238
b cell homeostasisGO:000178210.237
regulation of inflammatory response to antigenic stimulusGO:000286120.236
positive regulation of cell proliferationGO:00082843010.236
negative regulation of cell proliferationGO:00082852280.232
cellular glucose homeostasisGO:0001678110.232
lymphocyte mediated immunityGO:0002449480.223
Mouse
regulation of protein secretionGO:0050708860.221
production of molecular mediator of immune responseGO:0002440370.220
detection of external biotic stimulusGO:0098581190.219
detection of other organismGO:0098543130.214
negative regulation of response to external stimulusGO:0032102830.204
antigen processing and presentation of exogenous peptide antigen via mhc class iiGO:001988640.199
Mouse
regulation of cellular ketone metabolic processGO:0010565500.195
regulation of secretion by cellGO:19035301770.195
response to bacteriumGO:00096171440.194
cellular response to glucose stimulusGO:0071333100.193
response to external biotic stimulusGO:00432072610.192
signal releaseGO:0023061700.191
regulation of secretionGO:00510461940.183
negative regulation of cell activationGO:0050866330.181
regulation of proteolysisGO:00301622930.170
response to monosaccharideGO:0034284200.170
regulation of protein transportGO:00512232130.170
inflammatory responseGO:0006954790.170
secretionGO:00469032540.169
glucose homeostasisGO:0042593310.164
positive regulation of secretionGO:00510471160.164
regulation of peptide hormone secretionGO:0090276410.162
interleukin 4 productionGO:003263370.155
lymphocyte activation involved in immune responseGO:0002285200.150
cellular response to oxygen containing compoundGO:19017012760.149
negative regulation of t cell proliferationGO:004213080.148
carbohydrate homeostasisGO:0033500310.141
negative regulation of response to woundingGO:1903035470.136
chemokine c x c motif ligand 2 productionGO:007256730.127
protein maturationGO:00516042330.126
regulation of interleukin 4 productionGO:003267370.120
unsaturated fatty acid metabolic processGO:0033559370.115
cell cell signalingGO:00072671550.113
regulation of chemokine c x c motif ligand 2 productionGO:200034120.110
erk1 and erk2 cascadeGO:00703711040.109
t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cellGO:000229140.109
regulation of inflammatory responseGO:0050727460.105
positive regulation of protein kinase activityGO:00458601900.105
regulation of protein processingGO:00706131500.104
regulation of protein localizationGO:00328802960.102
positive regulation of transportGO:00510503360.099
negative regulation of lymphocyte activationGO:0051250240.098
peptide hormone secretionGO:0030072500.098
fatty acid derivative metabolic processGO:1901568350.090
cellular chemical homeostasisGO:00550821800.088
mapk cascadeGO:00001652880.086
regulation of hormone levelsGO:00108171250.086
protein oligomerizationGO:00512591730.084
cellular response to molecule of bacterial originGO:0071219620.084
regulation of apoptotic signaling pathwayGO:20012331750.081
signal transduction by phosphorylationGO:00230142970.081
cellular response to hexose stimulusGO:0071331100.081
chaperone mediated protein folding requiring cofactorGO:005108510.079
Mouse
negative regulation of catalytic activityGO:00430863350.078
b cell mediated immunityGO:0019724100.077
Mouse
neurological system processGO:00508771630.077
Human
regulation of leukocyte differentiationGO:1902105610.076
Mouse
hormone transportGO:0009914680.074
negative regulation of lymphocyte proliferationGO:0050672150.073
response to cytokineGO:00340972320.072
hematopoietic or lymphoid organ developmentGO:00485341860.072
Mouse
regulation of cell motilityGO:20001452990.072
negative regulation of leukocyte proliferationGO:0070664160.072
protein secretionGO:0009306980.070
positive regulation of cellular amine metabolic processGO:003324070.070
negative regulation of peptidase activityGO:0010466910.067
protein tetramerizationGO:0051262470.065
negative regulation of cell deathGO:00605483450.065
insulin secretionGO:0030073390.064
prostaglandin metabolic processGO:0006693170.064
negative regulation of inflammatory responseGO:0050728220.064
positive regulation of response to external stimulusGO:0032103880.063
cellular response to cytokine stimulusGO:00713451810.063
leukocyte activation involved in immune responseGO:0002366300.061
regulation of establishment of protein localizationGO:00702012420.058
negative regulation of hydrolase activityGO:00513461820.058
negative regulation of b cell apoptotic processGO:000290340.058
positive regulation of cytokine productionGO:00018191670.057
regulation of insulin secretionGO:0050796330.056
regulation of production of molecular mediator of immune responseGO:0002700250.056
cytokine mediated signaling pathwayGO:00192211090.055
negative regulation of immune responseGO:0050777400.054
negative regulation of homeostatic processGO:0032845590.053
cellular amine metabolic processGO:0044106410.051
regulation of hormone secretionGO:0046883570.046
positive regulation of immune effector processGO:0002699400.044
posttranscriptional regulation of gene expressionGO:00106082130.044
azole transportGO:004511740.043
fatty acid derivative biosynthetic processGO:1901570180.043
immunoglobulin productionGO:0002377120.042
positive regulation of homeostatic processGO:0032846470.041
cellular amino acid metabolic processGO:00065201160.041
immunoglobulin mediated immune responseGO:0016064100.039
Mouse
t cell activation involved in immune responseGO:0002286130.039
regulation of kinase activityGO:00435493140.039
regulation of antigen processing and presentation of peptide antigen via mhc class iiGO:000258630.037
Human
regulation of neutrophil migrationGO:1902622100.036
taxisGO:00423301570.035
interleukin 10 secretionGO:007260850.034
cell projection organizationGO:00300302520.034
regulation of cytokine secretionGO:0050707570.033
post embryonic developmentGO:000979120.033
positive regulation of cellular component movementGO:00512721810.032
regenerationGO:003109940.032
positive regulation of kinase activityGO:00336742040.032
positive regulation of interferon gamma productionGO:0032729260.031
regulation of mature b cell apoptotic processGO:000290510.031
response to lipidGO:00339932060.030
positive regulation of cell deathGO:00109422630.030
protein processingGO:00164852260.030
cellular lipid metabolic processGO:00442553030.030
regulation of homeostatic processGO:00328441210.029
monocarboxylic acid biosynthetic processGO:0072330670.029
system processGO:00030083490.028
Human
regulation of response to external stimulusGO:00321012220.028
amine metabolic processGO:0009308440.028
regulation of complement activation lectin pathwayGO:000186820.028
positive regulation of t helper 1 type immune responseGO:000282740.027
cellular response to carbohydrate stimulusGO:0071322110.027
negative regulation of cell differentiationGO:00455961710.027
multicellular organismal agingGO:001025930.026
pyrimidine containing compound transmembrane transportGO:007253140.025
negative regulation of mononuclear cell proliferationGO:0032945150.025
response to interferon gammaGO:0034341390.025
negative regulation of leukocyte activationGO:0002695260.025
response to biotic stimulusGO:00096072760.025
response to molecule of bacterial originGO:0002237820.025
chemical homeostasisGO:00488783060.024
negative regulation of cellular component organizationGO:00511292350.024
negative regulation of phosphatidylinositol 3 kinase signalingGO:001406740.024
generation of neuronsGO:00486991520.024
negative regulation of programmed cell deathGO:00430693210.023
biological adhesionGO:00226103310.023
regulation of cellular response to stressGO:00801352440.022
negative regulation of apoptotic signaling pathwayGO:2001234970.022
regulation of transferase activityGO:00513383550.021
response to fungusGO:000962040.021
oogenesisGO:004847720.021
detection of bacteriumGO:0016045130.020
monocarboxylic acid metabolic processGO:00327871850.020
response to corticosteroidGO:0031960150.020
cognitionGO:0050890430.020
Human
cellular response to dna damage stimulusGO:00069743790.020
regulation of cell developmentGO:00602841610.019
endocytosisGO:00068971590.019
regulation of cellular amino acid metabolic processGO:000652160.019
negative regulation of apoptotic processGO:00430663160.019
chemokine c c motif ligand 21 signaling pathwayGO:003811610.019
cation transportGO:00068123310.019
positive regulation of cell migrationGO:00303351720.019
immune response regulating cell surface receptor signaling pathwayGO:0002768510.019
inositol lipid mediated signalingGO:0048017550.019
determination of adult lifespanGO:000834020.019
negative regulation of transportGO:00510511760.019
regulation of mapk cascadeGO:00434082620.018
cellular cation homeostasisGO:00300031630.018
regulation of protein stabilityGO:0031647870.018
proteolysis involved in cellular protein catabolic processGO:00516032440.018
negative regulation of protein metabolic processGO:00512483910.017
response to carbohydrateGO:0009743210.017
carbohydrate metabolic processGO:00059752070.017
regulation of leukocyte chemotaxisGO:0002688460.017
compound eye developmentGO:004874910.017
regulation of nucleotide metabolic processGO:00061402690.017
lymphocyte apoptotic processGO:0070227200.017
positive regulation of locomotionGO:00400171860.017
cellular response to hormone stimulusGO:00328701250.016
protein catabolic processGO:00301633250.016
regulation of protein maturationGO:19033171500.016
cellular response to oxidative stressGO:0034599850.016
negative regulation of phosphorus metabolic processGO:00105632670.016
negative regulation of intracellular signal transductionGO:19025321830.015
ameboidal type cell migrationGO:00016671350.015
negative regulation of dendritic cell differentiationGO:200119920.015
negative regulation of cytokine productionGO:0001818820.015
cell developmentGO:00484683280.015
modification dependent protein catabolic processGO:00199412090.015
small molecule biosynthetic processGO:00442831570.015
regulation of peptide secretionGO:0002791420.014
response to organic cyclic compoundGO:00140702040.014
negative regulation of protein processingGO:00109551420.014
ribonucleoside triphosphate catabolic processGO:00092033910.014
lipid metabolic processGO:00066293810.014
ras protein signal transductionGO:0007265730.014
mitotic cell cycleGO:00002783260.014
cellular protein catabolic processGO:00442572610.014
cell type specific apoptotic processGO:00972851250.014
regulation of interleukin 10 productionGO:0032653160.013
cellular amide metabolic processGO:0043603690.013
nucleoside phosphate catabolic processGO:19012924120.013
insulin secretion involved in cellular response to glucose stimulusGO:003577370.013
intrinsic apoptotic signaling pathwayGO:00971931270.013
regulation of lipopolysaccharide mediated signaling pathwayGO:0031664130.013
nucleoside triphosphate catabolic processGO:00091433940.013
regulation of locomotionGO:00400123290.012
positive regulation of behaviorGO:0048520600.012
organelle assemblyGO:00709251760.012
small gtpase mediated signal transductionGO:0007264780.012
negative regulation of cellular protein metabolic processGO:00322693530.012
maintenance of locationGO:00512351120.012
negative regulation of cell developmentGO:0010721480.012
nervous system developmentGO:00073992930.012
regulation of type 2 immune responseGO:000282850.012
reactive oxygen species metabolic processGO:0072593750.012
regulation of peptidase activityGO:00525471800.012
cell morphogenesisGO:00009022960.012
negative regulation of interferon gamma productionGO:003268990.012
positive regulation of mapk cascadeGO:00434101900.012
ubiquitin dependent protein catabolic processGO:00065112060.012
negative regulation of phosphate metabolic processGO:00459362670.012
regulation of camp metabolic processGO:0030814520.012
regulation of vasculature developmentGO:1901342970.012
cellular macromolecule catabolic processGO:00442653800.012
cell cycle arrestGO:0007050710.012
intracellular protein transportGO:00068862700.012
purine ribonucleoside triphosphate metabolic processGO:00092054110.011
regulation of cellular amine metabolic processGO:0033238110.011
growthGO:00400072020.011
epithelial cell proliferationGO:00506731280.011
response to other organismGO:00517072610.011
response to nitrogen compoundGO:19016981840.011
regulation of t helper 1 type immune responseGO:000282550.011
regulation of neurogenesisGO:0050767820.011
organophosphate catabolic processGO:00464344300.011
multicellular organismal metabolic processGO:0044236340.011
response to abiotic stimulusGO:00096283360.011
positive regulation of cellular component organizationGO:00511303760.011
single organism carbohydrate metabolic processGO:00447231930.011
regulation of cellular component movementGO:00512703340.011
memoryGO:000761330.011
positive regulation of adaptive immune responseGO:0002821210.011
Mouse
positive regulation of phosphorylationGO:00423273940.011
response to dexamethasoneGO:007154810.011
regulation of protein catabolic processGO:00421761550.011
protein modification by small protein conjugationGO:00324463420.011
cellular response to glucocorticoid stimulusGO:007138540.011
regulation of intracellular transport of viral materialGO:190125220.011
regulation of anatomical structure sizeGO:00900661010.011
regulation of protein modification by small protein conjugation or removalGO:19033201070.011
cellular response to organonitrogen compoundGO:00714171240.011
regulation of t cell tolerance inductionGO:000266440.011
mitotic cell cycle phase transitionGO:00447721620.010
regulation of chemotaxisGO:0050920740.010
negative regulation of chemotaxisGO:0050922130.010
protein ubiquitinationGO:00165673140.010
positive regulation of transferase activityGO:00513472270.010
negative regulation of calcium ion importGO:009028110.010
neuron developmentGO:00486661130.010
cell growthGO:00160491600.010
protein polyubiquitinationGO:00002091100.010
cell activation involved in immune responseGO:0002263300.010

HLA-DMA disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
connective tissue diseaseDOID:651090.992
bone diseaseDOID:0080001880.992
musculoskeletal system diseaseDOID:172230.992
immune system diseaseDOID:29141550.991
Human
neurodegenerative diseaseDOID:12891020.929
nervous system diseaseDOID:8634310.929
central nervous system diseaseDOID:3311860.929
hypersensitivity reaction diseaseDOID:0060056250.836
Human
arthritisDOID:84880.104
bone inflammation diseaseDOID:3342100.104
rheumatoid arthritisDOID:714880.031
disease of metabolismDOID:00146672950.028
inherited metabolic disorderDOID:6552420.025
primary immunodeficiency diseaseDOID:612360.018
lysosomal storage diseaseDOID:3211470.010