Homo sapiens

48 known processes

SPRED2

sprouty-related, EVH1 domain containing 2

(Aliases: Spred-2,FLJ31917,FLJ21897,MGC163164)

SPRED2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
amine metabolic processGO:0009308440.131
regulation of cellular ketone metabolic processGO:0010565500.120
cellular amine metabolic processGO:0044106410.119
cellular amino acid metabolic processGO:00065201160.111
regulation of cellular amine metabolic processGO:0033238110.105
cellular ketone metabolic processGO:0042180800.102
cell developmentGO:00484683280.095
purine ribonucleotide catabolic processGO:00091544040.091
regulation of kinase activityGO:00435493140.086
Mouse
regulation of cell differentiationGO:00455953930.081
nucleoside phosphate catabolic processGO:19012924120.075
regulation of cellular amino acid metabolic processGO:000652160.074
small gtpase mediated signal transductionGO:0007264780.073
positive regulation of cellular amino acid metabolic processGO:004576430.071
regulation of transferase activityGO:00513383550.070
Mouse
organophosphate catabolic processGO:00464344300.070
glycosyl compound catabolic processGO:19016584130.069
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.069
nucleotide catabolic processGO:00091664080.068
purine containing compound catabolic processGO:00725234110.067
purine ribonucleoside metabolic processGO:00461284370.067
post embryonic developmentGO:000979120.065
cellular component morphogenesisGO:00329893140.065
purine nucleoside triphosphate metabolic processGO:00091444120.063
purine nucleotide catabolic processGO:00061954050.063
regulation of cell migrationGO:00303342890.063
Human
nucleoside catabolic processGO:00091644080.061
nervous system developmentGO:00073992930.060
female gamete generationGO:000729220.059
purine ribonucleoside triphosphate metabolic processGO:00092054110.058
nucleoside triphosphate metabolic processGO:00091414220.058
mapk cascadeGO:00001652880.056
Mouse
regulation of mapk cascadeGO:00434082620.055
Mouse
negative regulation of multicellular organismal processGO:00512413170.055
Human
negative regulation of cellular protein metabolic processGO:00322693530.055
negative regulation of phosphate metabolic processGO:00459362670.054
purine nucleoside triphosphate catabolic processGO:00091463920.054
negative regulation of protein metabolic processGO:00512483910.054
positive regulation of developmental processGO:00510943140.053
positive regulation of hydrolase activityGO:00513453310.053
purine ribonucleoside triphosphate catabolic processGO:00092073910.053
purine ribonucleoside catabolic processGO:00461303980.052
oogenesisGO:004847720.052
purine nucleoside catabolic processGO:00061523980.051
regulation of nucleotide metabolic processGO:00061402690.051
ras protein signal transductionGO:0007265730.051
nucleoside triphosphate catabolic processGO:00091433940.050
negative regulation of phosphorus metabolic processGO:00105632670.050
ribonucleoside triphosphate metabolic processGO:00091994120.050
positive regulation of cellular amine metabolic processGO:003324070.050
regulation of protein kinase activityGO:00458592890.050
Mouse
negative regulation of catalytic activityGO:00430863350.050
Human Mouse
negative regulation of cellular amine metabolic processGO:003323930.049
ribonucleoside catabolic processGO:00424544060.048
regulation of locomotionGO:00400123290.048
Human
guanosine containing compound catabolic processGO:19010692390.048
guanosine containing compound metabolic processGO:19010682440.048
negative regulation of apoptotic processGO:00430663160.048
signal transduction by phosphorylationGO:00230142970.047
Mouse
ribonucleoside triphosphate catabolic processGO:00092033910.047
anatomical structure formation involved in morphogenesisGO:00486462840.047
ribonucleotide catabolic processGO:00092614050.047
positive regulation of cellular component organizationGO:00511303760.046
Human
rho protein signal transductionGO:0007266260.046
cell morphogenesisGO:00009022960.045
system processGO:00030083490.045
cation transportGO:00068123310.045
negative regulation of cell deathGO:00605483450.045
regulation of cellular component movementGO:00512703340.044
Human
response to oxygen containing compoundGO:19017003690.043
gtp metabolic processGO:00460392390.042
vesicle mediated transportGO:00161923710.042
regulation of purine nucleotide catabolic processGO:00331212050.042
lipid metabolic processGO:00066293810.042
cellular response to endogenous stimulusGO:00714953360.042
positive regulation of cell proliferationGO:00082843010.041
regulation of purine nucleotide metabolic processGO:19005422640.041
regulation of protein serine threonine kinase activityGO:00719001790.040
Mouse
multicellular organismal agingGO:001025930.040
regulation of nucleotide catabolic processGO:00308112050.040
positive regulation of cellular catabolic processGO:00313312840.040
regulation of anatomical structure morphogenesisGO:00226032860.040
segmentationGO:003528240.040
enzyme linked receptor protein signaling pathwayGO:00071673030.039
actin filament based processGO:00300292240.039
Human
positive regulation of catabolic processGO:00098963100.039
regulation of cell cycleGO:00517263930.039
gtp catabolic processGO:00061842370.038
positive regulation of cell differentiationGO:00455972110.038
determination of adult lifespanGO:000834020.038
regulation of gtp catabolic processGO:00331241800.038
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.036
negative regulation of cell proliferationGO:00082852280.036
response to biotic stimulusGO:00096072760.036
locomotory behaviorGO:000762610.035
cell projection organizationGO:00300302520.035
Human
cardiovascular system developmentGO:00723582620.035
positive regulation of phosphorylationGO:00423273940.035
circulatory system developmentGO:00723592620.035
epithelium developmentGO:00604292270.035
single organism cellular localizationGO:19025803320.035
biological adhesionGO:00226103310.035
negative regulation of protein phosphorylationGO:00019331400.035
negative regulation of programmed cell deathGO:00430693210.034
hindbrain developmentGO:003090230.033
cellular response to oxygen containing compoundGO:19017012760.033
response to other organismGO:00517072610.033
regulation of nucleoside metabolic processGO:00091182090.033
positive regulation of protein phosphorylationGO:00019343130.033
immune responseGO:00069553070.033
cellular macromolecular complex assemblyGO:00346223240.033
Human
anterior posterior axis specificationGO:000994820.031
positive regulation of immune system processGO:00026842830.031
positive regulation of purine nucleotide metabolic processGO:19005442270.031
cellular lipid metabolic processGO:00442553030.031
regulation of cellular component biogenesisGO:00440872810.031
Human
protein catabolic processGO:00301633250.031
mitotic cell cycleGO:00002783260.031
neurogenesisGO:00220081690.030
negative regulation of protein modification processGO:00314002000.030
regulation of cell motilityGO:20001452990.030
Human
dephosphorylationGO:00163112090.030
Human
response to growth factorGO:00708482050.030
negative regulation of cellular amino acid metabolic processGO:004576320.029
carbohydrate metabolic processGO:00059752070.029
morphogenesis of embryonic epitheliumGO:001633140.029
cell activationGO:00017752130.029
epithelium migrationGO:00901321190.029
Human
response to external biotic stimulusGO:00432072610.029
positive regulation of transportGO:00510503360.029
generation of neuronsGO:00486991520.029
oocyte differentiationGO:000999420.029
secretionGO:00469032540.028
ameboidal type cell migrationGO:00016671350.028
Human
negative regulation of developmental processGO:00510932470.028
positive regulation of locomotionGO:00400171860.028
cytoplasmic transportGO:00164823790.028
neuromuscular junction developmentGO:000752830.028
regulation of proteolysisGO:00301622930.028
negative regulation of phosphorylationGO:00423261740.027
immune system developmentGO:00025201950.027
regulation of gtpase activityGO:00430871800.027
metal ion transportGO:00300012720.027
cellular macromolecule catabolic processGO:00442653800.027
negative regulation of intracellular signal transductionGO:19025321830.027
Mouse
defense responseGO:00069523150.027
regulation of ras protein signal transductionGO:00465781550.027
response to abiotic stimulusGO:00096283360.027
positive regulation of nucleotide metabolic processGO:00459812300.027
growthGO:00400072020.026
regulation of cellular response to stressGO:00801352440.026
Mouse
positive regulation of protein kinase activityGO:00458601900.026
response to lipidGO:00339932060.026
transmembrane transportGO:00550853990.026
epithelial cell migrationGO:00106311190.026
Human
cellular response to dna damage stimulusGO:00069743790.026
Mouse
positive regulation of cell deathGO:00109422630.026
negative regulation of transferase activityGO:00513481240.026
Mouse
positive regulation of kinase activityGO:00336742040.026
apoptotic signaling pathwayGO:00971902680.026
oocyte developmentGO:004859910.025
regulation of map kinase activityGO:00434051080.025
Mouse
regulation of cytokine productionGO:00018172320.025
positive regulation of purine nucleotide catabolic processGO:00331231850.025
peripheral nervous system developmentGO:000742220.025
regulation of cell projection organizationGO:00313441070.025
Human
membrane organizationGO:00610242920.024
negative regulation of kinase activityGO:00336731060.024
Mouse
positive regulation of nucleoside metabolic processGO:00459791860.024
positive regulation of transferase activityGO:00513472270.024
regulation of cell developmentGO:00602841610.024
blastoderm segmentationGO:000735020.024
cellular response to growth factor stimulusGO:00713631970.024
mitotic cell cycle processGO:19030472860.024
positive regulation of nucleotide catabolic processGO:00308131850.024
positive regulation of gtpase activityGO:00435471660.024
cell cell signalingGO:00072671550.024
regulation of protein transportGO:00512232130.024
positive regulation of apoptotic processGO:00430652460.024
secretion by cellGO:00329402260.024
regulation of protein localizationGO:00328802960.024
positive regulation of programmed cell deathGO:00430682490.024
positive regulation of mapk cascadeGO:00434101900.024
regulation of cell cycle processGO:00105642660.024
chemical homeostasisGO:00488783060.024
vasculature developmentGO:00019441810.023
response to organic cyclic compoundGO:00140702040.023
actin cytoskeleton organizationGO:00300362070.023
Human
regulation of ras gtpase activityGO:00323181280.023
neuron differentiationGO:00301821380.023
ion homeostasisGO:00508012300.023
regenerationGO:003109940.023
regulation of sequence specific dna binding transcription factor activityGO:00510902110.023
response to cytokineGO:00340972320.023
positive regulation of organelle organizationGO:00106381950.023
Human
erk1 and erk2 cascadeGO:00703711040.023
cell adhesionGO:00071553250.023
protein modification by small protein conjugationGO:00324463420.023
cell projection morphogenesisGO:00488581290.023
cytokine productionGO:00018162470.022
positive regulation of cell migrationGO:00303351720.022
positive regulation of gtp catabolic processGO:00331261660.022
hemopoiesisGO:00300971800.022
intracellular protein transportGO:00068862700.022
organonitrogen compound biosynthetic processGO:19015662000.022
organ morphogenesisGO:00098871470.022
chemotaxisGO:00069351570.022
protein maturationGO:00516042330.022
hematopoietic or lymphoid organ developmentGO:00485341860.022
oxidation reduction processGO:00551143960.022
chromatin organizationGO:00063253510.022
nitrogen compound transportGO:00717051910.022
regulation of epithelial cell migrationGO:0010632930.021
Human
cellular response to cytokine stimulusGO:00713451810.021
cellular protein catabolic processGO:00442572610.021
ion transmembrane transportGO:00342203380.021
regulation of growthGO:00400081650.021
leukocyte activationGO:00453211640.021
memoryGO:000761330.021
covalent chromatin modificationGO:00165692540.021
positive regulation of cell motilityGO:20001471770.021
protein localization to organelleGO:00333652800.021
single organism carbohydrate metabolic processGO:00447231930.021
protein ubiquitinationGO:00165673140.021
regulation of cytoskeleton organizationGO:00514931770.021
Human
rhythmic behaviorGO:000762220.021
cell part morphogenesisGO:00329901370.021
regulation of response to external stimulusGO:00321012220.020
carbohydrate derivative biosynthetic processGO:19011372070.020
embryonic epithelial tube formationGO:000183840.020
protein processingGO:00164852260.020
regulation of small gtpase mediated signal transductionGO:00510561560.020
regulation of multi organism processGO:00439001570.020
negative regulation of protein kinase activityGO:0006469980.020
Mouse
negative regulation of cellular component organizationGO:00511292350.020
Human
cell morphogenesis involved in differentiationGO:00009041440.020
proteolysis involved in cellular protein catabolic processGO:00516032440.020
regulation of cell morphogenesisGO:00226041530.020
neurological system processGO:00508771630.020
protein localization to membraneGO:00726571600.020
single organism cell adhesionGO:00986021790.020
inner ear morphogenesisGO:004247240.020
single organism membrane organizationGO:00448022680.020
adult locomotory behaviorGO:000834410.019
inorganic ion transmembrane transportGO:00986602310.019
peptidyl tyrosine phosphorylationGO:00181081700.019
negative regulation of hydrolase activityGO:00513461820.019
Human
limbic system developmentGO:002176130.019
blood vessel developmentGO:00015681720.019
negative regulation of cell cycleGO:00457861930.019
innate immune responseGO:00450871780.019
regulation of i kappab kinase nf kappab signalingGO:00431221620.019
angiogenesisGO:00015251470.019
inorganic cation transmembrane transportGO:00986621940.019
spermatid differentiationGO:004851540.019
chromatin modificationGO:00165682980.019
neuron developmentGO:00486661130.019
anterior posterior axis specification embryoGO:000859520.019
nerve developmentGO:002167540.019
cellular response to lipidGO:00713961270.019
regulation of intracellular transportGO:00323861950.019
regulation of hormone levelsGO:00108171250.018
cell projection assemblyGO:00300311260.018
Human
cell fate determinationGO:000170930.018
proteasomal protein catabolic processGO:00104981760.018
regulation of synaptic plasticityGO:004816730.018
tissue migrationGO:00901301190.018
Human
maintenance of locationGO:00512351120.018
neuron projection developmentGO:00311751060.018
tube morphogenesisGO:0035239950.018
regulation of erk1 and erk2 cascadeGO:0070372990.018
cellular protein complex assemblyGO:00436231880.018
Human
circadian behaviorGO:004851220.018
regulation of immune responseGO:00507762010.018
tube developmentGO:00352951250.018
regulation of establishment of protein localizationGO:00702012420.018
anion transportGO:00068201610.018
regulation of vesicle mediated transportGO:00606271300.018
response to inorganic substanceGO:00100351270.018
endocytosisGO:00068971590.018
positive regulation of cellular component movementGO:00512721810.018
neurotransmitter secretionGO:000726940.018
regulation of secretionGO:00510461940.018
endothelial cell migrationGO:0043542860.018
positive regulation of cell cycleGO:00457871400.018
protein targetingGO:00066051870.018
histone modificationGO:00165702510.018
salivary gland morphogenesisGO:000743540.018
regulation of secretion by cellGO:19035301770.018
modification dependent protein catabolic processGO:00199412090.017
cellular homeostasisGO:00197251960.017
muscle structure developmentGO:0061061980.017
regulation of protein complex assemblyGO:00432541470.017
Human
monocarboxylic acid metabolic processGO:00327871850.017
positive regulation of cytokine productionGO:00018191670.017
interspecies interaction between organismsGO:00444191560.017
regulation of cell growthGO:00015581350.017
compound eye developmentGO:004874910.017
divalent metal ion transportGO:00708381520.017
microtubule based processGO:00070172100.017
regulation of protein catabolic processGO:00421761550.017
neuroblast proliferationGO:000740540.017
central nervous system developmentGO:00074171230.017
endomembrane system organizationGO:00102561960.017
organelle assemblyGO:00709251760.017
regulation of cell adhesionGO:00301551660.017
positive regulation of cell developmentGO:0010720920.017
epithelial cell differentiationGO:00308551410.017
response to nitrogen compoundGO:19016981840.017
nuclear transportGO:00511691790.017
organic hydroxy compound metabolic processGO:19016151470.017
organ formationGO:004864530.017
tripartite regional subdivisionGO:000735120.017
cation homeostasisGO:00550801890.017
negative regulation of cellular component movementGO:00512711060.017
Human
response to woundingGO:00096111680.017
positive regulation of proteolysisGO:00458621420.017
sequestering of calcium ionGO:0051208170.017
positive regulation of synaptic transmissionGO:005080640.017
positive regulation of protein serine threonine kinase activityGO:00719021190.016
multi organism cellular processGO:00447641560.016
actin filament organizationGO:00070151280.016
Human
cell divisionGO:00513011680.016
spermatid developmentGO:000728640.016
regulation of defense responseGO:00313471540.016
cellular chemical homeostasisGO:00550821800.016
glycoprotein metabolic processGO:00091001100.016
negative regulation of locomotionGO:00400131180.016
Human
posttranscriptional regulation of gene expressionGO:00106082130.016
cell growthGO:00160491600.016
negative regulation of cell differentiationGO:00455961710.016
microtubule cytoskeleton organizationGO:00002261760.016
peptidyl tyrosine modificationGO:00182121700.016
regulation of mitotic cell cycleGO:00073461890.016
behaviorGO:00076101120.016
cation transmembrane transportGO:00986552380.016
response to bacteriumGO:00096171440.016
metal ion homeostasisGO:00550651690.016
response to axon injuryGO:004867810.016
i kappab kinase nf kappab signalingGO:00072491660.016
negative regulation of catabolic processGO:00098951040.016
matingGO:000761810.016
organic anion transportGO:00157111030.016
motor neuron axon guidanceGO:000804520.016
organophosphate biosynthetic processGO:00904071630.016
ossificationGO:00015031210.015
regulation of homeostatic processGO:00328441210.015
regulation of neurotransmitter secretionGO:004692830.015
modification dependent macromolecule catabolic processGO:00436322120.015
peptidyl serine modificationGO:00182091060.015
regulation of actin filament based processGO:00329701410.015
Human
lung alveolus developmentGO:004828640.015
regulation of ion transportGO:00432691890.015
purine ribonucleoside monophosphate metabolic processGO:00091671860.015
divalent inorganic cation transportGO:00725111580.015
purine nucleoside monophosphate metabolic processGO:00091261860.015
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.015
regulation of cytoplasmic transportGO:19036491490.015
blood vessel morphogenesisGO:00485141620.015
glial cell migrationGO:000834740.015
forebrain generation of neuronsGO:002187230.015
regulation of neuron projection developmentGO:0010975570.015
regulation of apoptotic signaling pathwayGO:20012331750.015
syncytium formation by plasma membrane fusionGO:000076820.015
tissue morphogenesisGO:0048729960.015
cell type specific apoptotic processGO:00972851250.015
sensory perception of painGO:001923340.015
phospholipid metabolic processGO:0006644990.015
regulation of leukocyte activationGO:00026941150.014
axis elongationGO:000340140.014
establishment of protein localization to membraneGO:00901501210.014
response to drugGO:0042493810.014
protein localization to nucleusGO:00345041360.014
neural tube formationGO:000184130.014
thymus developmentGO:004853830.014
primary neural tube formationGO:001402030.014
rna processingGO:00063962550.014
protein oligomerizationGO:00512591730.014
regulation of endopeptidase activityGO:00525481700.014
morphogenesis of a polarized epitheliumGO:000173830.014
head developmentGO:00603221080.014
regulation of wnt signaling pathwayGO:00301111230.014
symbiosis encompassing mutualism through parasitismGO:00444031560.014
response to virusGO:00096151260.014
neuron projection regenerationGO:003110210.014
ubiquitin dependent protein catabolic processGO:00065112060.014
positive regulation of cellular component biogenesisGO:00440891580.014
Human
small molecule biosynthetic processGO:00442831570.014
neural crest cell developmentGO:001403230.014
regulation of membrane potentialGO:0042391950.014
ribonucleoside monophosphate metabolic processGO:00091611870.014
regulation of cell activationGO:00508651250.014
nucleocytoplasmic transportGO:00069131760.014
regulation of dna metabolic processGO:00510521530.014
negative regulation of cell cycle processGO:00109481210.014
associative learningGO:000830610.014
response to oxidative stressGO:00069791210.014
regulation of lymphocyte activationGO:00512491030.014
alcohol metabolic processGO:00060661140.014
response to hormoneGO:00097251750.014
regulation of actin cytoskeleton organizationGO:00329561160.014
Human
regulation of neurogenesisGO:0050767820.014
endodermal cell fate commitmentGO:000171140.014
response to fungusGO:000962040.014
peptidyl threonine phosphorylationGO:0018107410.014
cranial nerve developmentGO:002154540.014
myoblast fusionGO:000752010.014
fatty acid metabolic processGO:00066311150.014
viral processGO:00160321460.014
photoreceptor cell differentiationGO:004653020.014
immune effector processGO:00022521590.014
establishment of protein localization to organelleGO:00725941720.014
cell cycle phase transitionGO:00447701730.014
epithelial cell proliferationGO:00506731280.013
lipid biosynthetic processGO:00086101770.013
regulation of dephosphorylationGO:0035303960.013
Human
cellular response to organic cyclic compoundGO:00714071270.013
cellular metal ion homeostasisGO:00068751460.013
signal releaseGO:0023061700.013
positive regulation of ras gtpase activityGO:00323201170.013
negative regulation of cell migrationGO:00303361020.013
Human
response to organonitrogen compoundGO:00102431560.013
glycoprotein biosynthetic processGO:0009101910.013
negative regulation of protein serine threonine kinase activityGO:0071901570.013
Mouse
tube closureGO:006060630.013
calcium ion transportGO:00068161470.013
melanin metabolic processGO:000658210.013
cellular response to organonitrogen compoundGO:00714171240.013
extrinsic apoptotic signaling pathwayGO:00971911190.013
reactive oxygen species biosynthetic processGO:190340940.013
mammary gland morphogenesisGO:006044320.013
taxisGO:00423301570.013
regulation of phosphatase activityGO:0010921810.013
Human
nucleoside monophosphate metabolic processGO:00091231910.013
sequestering of metal ionGO:0051238240.013
actin filament based movementGO:0030048170.013
regulation of epithelial cell proliferationGO:00506781130.013
regulation of rho gtpase activityGO:0032319660.013
atp metabolic processGO:00460341760.013
protein kinase b signalingGO:0043491690.013
hormone transportGO:0009914680.013
wnt signaling pathwayGO:00160551560.013
forebrain neuron differentiationGO:002187930.013
regulation of peptidase activityGO:00525471800.013
organic acid biosynthetic processGO:0016053970.013
actin mediated cell contractionGO:0070252120.013
regulation of response to woundingGO:19030341010.013
cardiac muscle cell contractionGO:008600340.013
endosomal transportGO:00161971290.013
organelle fissionGO:00482851490.013
branch elongation of an epitheliumGO:006060230.013
cell chemotaxisGO:00603261120.013
mitochondrion organizationGO:00070051560.013
carboxylic acid biosynthetic processGO:0046394970.012
spinal cord developmentGO:002151040.012
negative regulation of cell motilityGO:20001461040.012
Human
lipid localizationGO:00108761060.012
pericardium developmentGO:006003920.012
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.012
regulation of cell morphogenesis involved in differentiationGO:0010769830.012
establishment of planar polarityGO:000173630.012
reactive oxygen species metabolic processGO:0072593750.012
regulation of endocytosisGO:0030100720.012
embryonic camera type eye developmentGO:003107620.012
embryo developmentGO:00097901230.012
protein dephosphorylationGO:0006470810.012
stem cell divisionGO:001714520.012
single organismal cell cell adhesionGO:00163371480.012
regulation of cysteine type endopeptidase activityGO:20001161270.012
regulation of protein maturationGO:19033171500.012
activation of protein kinase activityGO:0032147900.012
regulation of neural precursor cell proliferationGO:200017740.012
neural tube closureGO:000184330.012
cell substrate adhesionGO:00315891320.012
protein acylationGO:00435431380.012
cellular cation homeostasisGO:00300031630.012
regulation of peptidyl tyrosine phosphorylationGO:00507301080.012
positive regulation of reactive oxygen species metabolic processGO:2000379240.012
negative regulation of cellular catabolic processGO:0031330830.012
negative regulation of protein maturationGO:19033181420.012

SPRED2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.035
inherited metabolic disorderDOID:6552420.028
musculoskeletal system diseaseDOID:172230.027
disease of cellular proliferationDOID:145661740.025
organ system cancerDOID:00506861640.023
cancerDOID:1621670.023
nervous system diseaseDOID:8634310.021
sensory system diseaseDOID:00501552030.021
connective tissue diseaseDOID:651090.019
eye and adnexa diseaseDOID:14921500.017
eye diseaseDOID:56141490.017
central nervous system diseaseDOID:3311860.016
bone diseaseDOID:0080001880.013