Homo sapiens

93 known processes

NPAS2

neuronal PAS domain protein 2

(Aliases: MOP4,bHLHe9,FLJ23138,PASD4,MGC71151)

NPAS2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of cellular ketone metabolic processGO:0010565500.246
cellular amino acid metabolic processGO:00065201160.233
cellular ketone metabolic processGO:0042180800.233
cell developmentGO:00484683280.184
regulation of cell differentiationGO:00455953930.182
amine metabolic processGO:0009308440.179
regulation of cellular amine metabolic processGO:0033238110.163
cellular amine metabolic processGO:0044106410.158
circulatory system developmentGO:00723592620.140
regulation of cellular amino acid metabolic processGO:000652160.137
positive regulation of cellular amine metabolic processGO:003324070.134
positive regulation of cellular amino acid metabolic processGO:004576430.129
cardiovascular system developmentGO:00723582620.112
nervous system developmentGO:00073992930.112
system processGO:00030083490.109
regulation of cell motilityGO:20001452990.106
regulation of cell cycleGO:00517263930.101
cellular component morphogenesisGO:00329893140.101
negative regulation of cell deathGO:00605483450.096
post embryonic developmentGO:000979120.096
regulation of locomotionGO:00400123290.096
secretionGO:00469032540.096
cell adhesionGO:00071553250.095
small gtpase mediated signal transductionGO:0007264780.095
regulation of cell developmentGO:00602841610.094
anatomical structure formation involved in morphogenesisGO:00486462840.091
cellular response to endogenous stimulusGO:00714953360.091
cell morphogenesisGO:00009022960.091
epithelium developmentGO:00604292270.089
positive regulation of hormone biosynthetic processGO:004688640.086
positive regulation of phosphorylationGO:00423273940.085
regulation of cellular component biogenesisGO:00440872810.082
negative regulation of developmental processGO:00510932470.082
regulation of cell migrationGO:00303342890.081
vasculature developmentGO:00019441810.080
rhythmic behaviorGO:000762220.080
Mouse Fly
positive regulation of developmental processGO:00510943140.078
generation of neuronsGO:00486991520.078
enzyme linked receptor protein signaling pathwayGO:00071673030.077
regulation of anatomical structure morphogenesisGO:00226032860.076
regulation of hormone levelsGO:00108171250.074
glycosyl compound catabolic processGO:19016584130.072
oxidative stress induced premature senescenceGO:009040330.072
response to abiotic stimulusGO:00096283360.070
Human Fly
lipid metabolic processGO:00066293810.070
cytoplasmic transportGO:00164823790.069
regulation of cellular component movementGO:00512703340.068
cell projection organizationGO:00300302520.068
locomotory behaviorGO:000762610.068
Mouse Fly
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.067
positive regulation of protein phosphorylationGO:00019343130.066
biological adhesionGO:00226103310.065
purine ribonucleotide catabolic processGO:00091544040.065
response to oxygen containing compoundGO:19017003690.065
ras protein signal transductionGO:0007265730.065
nucleoside catabolic processGO:00091644080.065
rho protein signal transductionGO:0007266260.063
cellular response to oxygen containing compoundGO:19017012760.061
negative regulation of multicellular organismal processGO:00512413170.061
positive regulation of cell proliferationGO:00082843010.061
negative regulation of cell proliferationGO:00082852280.060
epithelium migrationGO:00901321190.060
neuron differentiationGO:00301821380.059
negative regulation of cellular protein metabolic processGO:00322693530.059
positive regulation of cellular component organizationGO:00511303760.058
negative regulation of apoptotic processGO:00430663160.057
purine nucleoside triphosphate catabolic processGO:00091463920.057
cell cell signalingGO:00072671550.056
cytokine productionGO:00018162470.056
neurogenesisGO:00220081690.056
nucleoside triphosphate catabolic processGO:00091433940.055
purine nucleotide catabolic processGO:00061954050.055
chemical homeostasisGO:00488783060.054
negative regulation of protein metabolic processGO:00512483910.054
purine containing compound catabolic processGO:00725234110.054
protein catabolic processGO:00301633250.054
purine ribonucleoside catabolic processGO:00461303980.053
negative regulation of cell differentiationGO:00455961710.053
purine nucleoside triphosphate metabolic processGO:00091444120.053
secretion by cellGO:00329402260.052
female gamete generationGO:000729220.052
purine nucleoside catabolic processGO:00061523980.052
organophosphate catabolic processGO:00464344300.052
single organism cellular localizationGO:19025803320.051
regulation of mapk cascadeGO:00434082620.051
ribonucleoside triphosphate catabolic processGO:00092033910.050
ribonucleotide catabolic processGO:00092614050.050
purine ribonucleoside triphosphate catabolic processGO:00092073910.050
negative regulation of phosphate metabolic processGO:00459362670.050
ameboidal type cell migrationGO:00016671350.050
regulation of secretion by cellGO:19035301770.050
regulation of kinase activityGO:00435493140.050
ribonucleoside catabolic processGO:00424544060.050
purine ribonucleoside triphosphate metabolic processGO:00092054110.050
nucleoside triphosphate metabolic processGO:00091414220.049
negative regulation of programmed cell deathGO:00430693210.049
cation transportGO:00068123310.049
mapk cascadeGO:00001652880.048
segmentationGO:003528240.048
positive regulation of cell differentiationGO:00455972110.048
positive regulation of hydrolase activityGO:00513453310.047
negative regulation of catalytic activityGO:00430863350.047
epithelial cell migrationGO:00106311190.047
regulation of secretionGO:00510461940.047
response to growth factorGO:00708482050.047
apoptotic signaling pathwayGO:00971902680.046
guanosine containing compound metabolic processGO:19010682440.046
actin filament based processGO:00300292240.046
chemotaxisGO:00069351570.046
vesicle mediated transportGO:00161923710.046
single organism cell adhesionGO:00986021790.045
carbohydrate metabolic processGO:00059752070.045
organ morphogenesisGO:00098871470.045
signal transduction by phosphorylationGO:00230142970.045
purine ribonucleoside metabolic processGO:00461284370.044
ribonucleoside triphosphate metabolic processGO:00091994120.044
nucleotide catabolic processGO:00091664080.044
cell morphogenesis involved in differentiationGO:00009041440.044
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.044
oogenesisGO:004847720.043
negative regulation of phosphorus metabolic processGO:00105632670.043
organic hydroxy compound metabolic processGO:19016151470.042
regulation of gtpase activityGO:00430871800.042
cellular lipid metabolic processGO:00442553030.042
tube developmentGO:00352951250.042
multicellular organismal agingGO:001025930.042
blood vessel developmentGO:00015681720.042
cellular response to growth factor stimulusGO:00713631970.042
negative regulation of cellular component organizationGO:00511292350.042
angiogenesisGO:00015251470.041
regulation of transferase activityGO:00513383550.041
gtp metabolic processGO:00460392390.041
hindbrain developmentGO:003090230.041
response to lipidGO:00339932060.041
regulation of nucleotide metabolic processGO:00061402690.041
immune responseGO:00069553070.041
negative regulation of intracellular signal transductionGO:19025321830.041
positive regulation of cellular catabolic processGO:00313312840.040
determination of adult lifespanGO:000834020.040
regulation of nervous system developmentGO:0051960880.040
regulation of purine nucleotide catabolic processGO:00331212050.039
regulation of sequence specific dna binding transcription factor activityGO:00510902110.039
cellular macromolecule catabolic processGO:00442653800.039
regulation of protein localizationGO:00328802960.039
neuron projection developmentGO:00311751060.039
nucleoside phosphate catabolic processGO:19012924120.039
positive regulation of mapk cascadeGO:00434101900.039
neurological system processGO:00508771630.038
nitrogen compound transportGO:00717051910.038
guanosine containing compound catabolic processGO:19010692390.038
regulation of purine nucleotide metabolic processGO:19005422640.038
regulation of protein kinase activityGO:00458592890.038
regenerationGO:003109940.037
regulation of epithelial cell migrationGO:0010632930.037
blood vessel morphogenesisGO:00485141620.037
single organismal cell cell adhesionGO:00163371480.037
protein localization to organelleGO:00333652800.037
single organism carbohydrate metabolic processGO:00447231930.037
hormone metabolic processGO:0042445610.037
positive regulation of immune system processGO:00026842830.036
regulation of nucleotide catabolic processGO:00308112050.036
positive regulation of catabolic processGO:00098963100.036
regulation of nucleoside metabolic processGO:00091182090.036
transmembrane transportGO:00550853990.035
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.035
taxisGO:00423301570.035
regulation of neurogenesisGO:0050767820.035
positive regulation of transportGO:00510503360.035
morphogenesis of embryonic epitheliumGO:001633140.035
regulation of vasculature developmentGO:1901342970.035
neuron developmentGO:00486661130.034
epithelial cell proliferationGO:00506731280.034
positive regulation of cell deathGO:00109422630.034
ion transmembrane transportGO:00342203380.034
dephosphorylationGO:00163112090.034
wnt signaling pathwayGO:00160551560.034
positive regulation of locomotionGO:00400171860.033
positive regulation of transferase activityGO:00513472270.033
regulation of synaptic plasticityGO:004816730.033
cellular macromolecular complex assemblyGO:00346223240.033
circadian behaviorGO:004851220.033
Mouse Fly
neuromuscular junction developmentGO:000752830.033
regulation of behaviorGO:0050795820.033
Fly
central nervous system developmentGO:00074171230.033
gtp catabolic processGO:00061842370.033
mitotic cell cycleGO:00002783260.033
regulation of cytokine productionGO:00018172320.032
response to cytokineGO:00340972320.032
positive regulation of cell motilityGO:20001471770.032
ion homeostasisGO:00508012300.032
memoryGO:000761330.032
forebrain generation of neuronsGO:002187230.031
circadian sleep wake cycleGO:004274520.031
Mouse Fly
defense responseGO:00069523150.031
growthGO:00400072020.031
response to organic cyclic compoundGO:00140702040.031
regulation of proteolysisGO:00301622930.031
response to hormoneGO:00097251750.031
regulation of cell adhesionGO:00301551660.031
negative regulation of cell migrationGO:00303361020.031
signal releaseGO:0023061700.031
brain developmentGO:0007420970.030
regulation of gtp catabolic processGO:00331241800.030
epithelial cell differentiationGO:00308551410.030
response to other organismGO:00517072610.030
peptidyl tyrosine modificationGO:00182121700.030
regulation of cellular response to stressGO:00801352440.030
positive regulation of cell migrationGO:00303351720.030
positive regulation of programmed cell deathGO:00430682490.030
regulation of growthGO:00400081650.030
positive regulation of interleukin 5 productionGO:003275430.030
tube morphogenesisGO:0035239950.030
membrane organizationGO:00610242920.030
positive regulation of protein kinase activityGO:00458601900.030
peptidyl tyrosine phosphorylationGO:00181081700.029
actin cytoskeleton organizationGO:00300362070.029
organ formationGO:004864530.029
cell substrate adhesionGO:00315891320.029
regulation of apoptotic signaling pathwayGO:20012331750.029
regulation of ras protein signal transductionGO:00465781550.029
inorganic ion transmembrane transportGO:00986602310.029
protein processingGO:00164852260.029
single organism membrane organizationGO:00448022680.029
regulation of cell growthGO:00015581350.029
oxidation reduction processGO:00551143960.029
positive regulation of cellular component movementGO:00512721810.029
positive regulation of cytokine productionGO:00018191670.028
positive regulation of apoptotic processGO:00430652460.028
cell activationGO:00017752130.028
endothelial cell migrationGO:0043542860.028
regulation of establishment of protein localizationGO:00702012420.028
regulation of wnt signaling pathwayGO:00301111230.028
cell projection morphogenesisGO:00488581290.028
amide transportGO:0042886760.028
regulation of cell cycle processGO:00105642660.028
behaviorGO:00076101120.028
Mouse Fly
regulation of axon guidanceGO:190266730.028
regulation of cell morphogenesisGO:00226041530.028
oocyte differentiationGO:000999420.028
salivary gland morphogenesisGO:000743540.028
negative regulation of hydrolase activityGO:00513461820.028
hormone secretionGO:0046879650.028
cation transmembrane transportGO:00986552380.028
peptide transportGO:0015833740.028
regulation of circadian sleep wake cycle sleepGO:004518720.028
Fly
regulation of cytoskeleton organizationGO:00514931770.028
cell part morphogenesisGO:00329901370.028
outflow tract septum morphogenesisGO:000314840.028
tissue migrationGO:00901301190.028
chromatin modificationGO:00165682980.028
Human
muscle structure developmentGO:0061061980.028
immune system developmentGO:00025201950.028
regulation of protein transportGO:00512232130.027
protein targetingGO:00066051870.027
peripheral nervous system developmentGO:000742220.027
cellular response to organonitrogen compoundGO:00714171240.027
nucleocytoplasmic transportGO:00069131760.027
hematopoietic or lymphoid organ developmentGO:00485341860.027
oocyte developmentGO:004859910.027
response to hypoxiaGO:0001666960.027
blastoderm segmentationGO:000735020.027
response to biotic stimulusGO:00096072760.027
regulation of response to external stimulusGO:00321012220.027
cellular protein catabolic processGO:00442572610.027
response to oxidative stressGO:00069791210.027
positive regulation of cellular component biogenesisGO:00440891580.026
inner ear morphogenesisGO:004247240.026
metal ion transportGO:00300012720.026
positive regulation of nucleotide metabolic processGO:00459812300.026
positive regulation of purine nucleotide catabolic processGO:00331231850.026
intracellular protein transportGO:00068862700.026
negative regulation of phosphorylationGO:00423261740.026
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.026
cellular response to dna damage stimulusGO:00069743790.026
circadian sleep wake cycle processGO:002241020.026
Fly
canonical wnt signaling pathwayGO:00600701160.026
negative regulation of cellular component movementGO:00512711060.025
cellular response to organic cyclic compoundGO:00714071270.025
cellular response to oxidative stressGO:0034599850.025
regulation of protein serine threonine kinase activityGO:00719001790.025
proteolysis involved in cellular protein catabolic processGO:00516032440.025
positive regulation of purine nucleotide metabolic processGO:19005442270.025
neuroblast proliferationGO:000740540.025
hemopoiesisGO:00300971800.025
sleepGO:003043120.025
Fly
positive regulation of cell developmentGO:0010720920.025
positive regulation of organelle organizationGO:00106381950.025
lipid biosynthetic processGO:00086101770.025
positive regulation of kinase activityGO:00336742040.024
positive regulation of cell cycleGO:00457871400.024
post embryonic organ developmentGO:004856910.024
negative regulation of protein modification processGO:00314002000.024
innate immune responseGO:00450871780.024
regulation of peptidyl tyrosine phosphorylationGO:00507301080.024
regulation of immune responseGO:00507762010.024
response to decreased oxygen levelsGO:0036293960.024
small molecule biosynthetic processGO:00442831570.024
organonitrogen compound biosynthetic processGO:19015662000.024
cellular response to lipidGO:00713961270.024
anterior posterior axis specificationGO:000994820.024
tissue morphogenesisGO:0048729960.024
anion transportGO:00068201610.024
inorganic cation transmembrane transportGO:00986621940.024
posttranscriptional regulation of gene expressionGO:00106082130.024
protein maturationGO:00516042330.024
positive regulation of gtp catabolic processGO:00331261660.024
regulation of epithelial cell proliferationGO:00506781130.024
regulation of small gtpase mediated signal transductionGO:00510561560.024
negative regulation of protein maturationGO:19033181420.024
photoreceptor cell differentiationGO:004653020.024
intracellular receptor signaling pathwayGO:00305221040.024
peptide hormone secretionGO:0030072500.024
positive regulation of nucleotide catabolic processGO:00308131850.023
negative regulation of cellular amine metabolic processGO:003323930.023
hormone transportGO:0009914680.023
head developmentGO:00603221080.023
negative regulation of locomotionGO:00400131180.023
regulation of neuron differentiationGO:0045664700.023
endomembrane system organizationGO:00102561960.023
regulation of mitotic cell cycleGO:00073461890.023
regulation of ras gtpase activityGO:00323181280.023
cell growthGO:00160491600.023
regulation of neurotransmitter secretionGO:004692830.023
regulation of cell projection organizationGO:00313441070.023
motor neuron axon guidanceGO:000804520.023
positive regulation of gtpase activityGO:00435471660.023
ubiquitin dependent protein catabolic processGO:00065112060.023
retinal ganglion cell axon guidanceGO:003129020.022
nuclear transportGO:00511691790.022
protein localization to nucleusGO:00345041360.022
limbic system developmentGO:002176130.022
leukocyte activationGO:00453211640.022
positive regulation of nucleoside metabolic processGO:00459791860.022
neurotransmitter secretionGO:000726940.022
proteasomal protein catabolic processGO:00104981760.022
negative regulation of cellular amino acid metabolic processGO:004576320.022
regulation of membrane potentialGO:0042391950.022
negative regulation of cell cycleGO:00457861930.022
cation homeostasisGO:00550801890.022
regulation of lipid metabolic processGO:0019216960.022
digestive tract developmentGO:0048565750.022
cerebral cortex cell migrationGO:002179530.022
carbohydrate derivative biosynthetic processGO:19011372070.022
response to woundingGO:00096111680.022
cellular protein complex assemblyGO:00436231880.022
response to oxygen levelsGO:00704821000.022
covalent chromatin modificationGO:00165692540.022
Human
cell matrix adhesionGO:0007160850.022
circadian sleep wake cycle sleepGO:005080220.021
Fly
protein ubiquitinationGO:00165673140.021
response to external biotic stimulusGO:00432072610.021
cellular homeostasisGO:00197251960.021
cellular response to cytokine stimulusGO:00713451810.021
regulation of bindingGO:00510981110.021
regulation of protein processingGO:00706131500.021
monocarboxylic acid metabolic processGO:00327871850.021
regulation of protein complex assemblyGO:00432541470.021
adult locomotory behaviorGO:000834410.021
embryo developmentGO:00097901230.021
skeletal system developmentGO:0001501790.021
negative regulation of protein phosphorylationGO:00019331400.021
modification dependent macromolecule catabolic processGO:00436322120.021
endothelial cell proliferationGO:0001935650.021
cell fate determinationGO:000170930.021
regulation of multi organism processGO:00439001570.020
ossificationGO:00015031210.020
response to radiationGO:00093141510.020
Human
digestive system developmentGO:0055123750.020
alcohol metabolic processGO:00060661140.020
cell type specific apoptotic processGO:00972851250.020
regulation of hormone secretionGO:0046883570.020
negative regulation of transportGO:00510511760.020
regulation of protein maturationGO:19033171500.020
modification dependent protein catabolic processGO:00199412090.020
regulation of endopeptidase activityGO:00525481700.020
regulation of defense responseGO:00313471540.020
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.020
embryonic camera type eye developmentGO:003107620.020
embryonic morphogenesisGO:0048598850.020
reactive oxygen species biosynthetic processGO:190340940.020
associative learningGO:000830610.020
steroid metabolic processGO:0008202940.019
establishment of protein localization to organelleGO:00725941720.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.019
negative regulation of cell motilityGO:20001461040.019
positive regulation of synaptic transmissionGO:005080640.019
reproductive processGO:00224141060.019
regulation of peptidase activityGO:00525471800.019
reactive oxygen species metabolic processGO:0072593750.019
regulation of canonical wnt signaling pathwayGO:0060828880.019
protein modification by small protein conjugationGO:00324463420.019
cell junction organizationGO:0034330790.019
regulation of actin filament based processGO:00329701410.019
neural crest cell developmentGO:001403230.019
mitotic cell cycle processGO:19030472860.019
wound healingGO:00420601150.019
divalent metal ion transportGO:00708381520.019
cellular response to hormone stimulusGO:00328701250.019
cellular carbohydrate metabolic processGO:0044262840.019
cell projection assemblyGO:00300311260.019
actin filament organizationGO:00070151280.019
muscle contractionGO:0006936730.019
primary neural tube formationGO:001402030.018
negative regulation of proteolysisGO:00458611320.018
microtubule cytoskeleton organizationGO:00002261760.018
type b pancreatic cell developmentGO:000332340.018
regulation of cellular response to growth factor stimulusGO:0090287760.018
microtubule based processGO:00070172100.018
sensory perceptionGO:00076001030.018
epithelial tube branching involved in lung morphogenesisGO:006044140.018
extrinsic apoptotic signaling pathwayGO:00971911190.018
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.018
nerve developmentGO:002167540.018
forebrain neuron differentiationGO:002187930.018
startle responseGO:000196430.018
protein oligomerizationGO:00512591730.018
glycoprotein metabolic processGO:00091001100.018
cellular response to abiotic stimulusGO:00712141170.018
Human
spinal cord developmentGO:002151040.018
cell chemotaxisGO:00603261120.018
regulation of cell morphogenesis involved in differentiationGO:0010769830.018
response to organonitrogen compoundGO:00102431560.018
establishment of protein localization to membraneGO:00901501210.018
maintenance of locationGO:00512351120.018
multi organism cellular processGO:00447641560.018
embryonic epithelial tube formationGO:000183840.018
regulation of protein catabolic processGO:00421761550.018
positive regulation of secretionGO:00510471160.018
cranial nerve developmentGO:002154540.018
regulation of intracellular transportGO:00323861950.018
positive regulation of ras gtpase activityGO:00323201170.018
response to axon injuryGO:004867810.018
regulation of ion transportGO:00432691890.018
hair cycleGO:0042633280.018
Human
negative regulation of protein processingGO:00109551420.017
protein localization to membraneGO:00726571600.017
regulation of angiogenesisGO:0045765920.017
compound eye developmentGO:004874910.017
cellular ion homeostasisGO:00068731680.017
spermatid differentiationGO:004851540.017
positive regulation of protein serine threonine kinase activityGO:00719021190.017
lymphocyte activationGO:00466491330.017
i kappab kinase nf kappab signalingGO:00072491660.017
anterior posterior axis specification embryoGO:000859520.017
negative regulation of growthGO:0045926970.017
histone modificationGO:00165702510.017
Human
erk1 and erk2 cascadeGO:00703711040.017
tripartite regional subdivisionGO:000735120.017
heart developmentGO:0007507950.017
plasma membrane organizationGO:00070091150.017
stem cell divisionGO:001714520.017
peptide secretionGO:0002790510.017
somatic stem cell maintenanceGO:003501940.017
chromatin organizationGO:00063253510.017
Human
regulation of peptide transportGO:0090087620.017
protein targeting to nucleusGO:00447441040.016
interspecies interaction between organismsGO:00444191560.016
single organism reproductive processGO:0044702980.016
prostate gland developmentGO:003085030.016
lipid localizationGO:00108761060.016
regulation of dna metabolic processGO:00510521530.016
regulation of endothelial cell migrationGO:0010594670.016
regulation of actin cytoskeleton organizationGO:00329561160.016
reactive nitrogen species metabolic processGO:200105730.016
positive regulation of immune responseGO:00507781590.016
regulation of transmembrane transportGO:00347621390.016
endocytosisGO:00068971590.016
cellular response to nitrogen compoundGO:19016991440.016
organic anion transportGO:00157111030.016
response to nitrogen compoundGO:19016981840.016
organelle assemblyGO:00709251760.016
negative regulation of transcription initiation from rna polymerase ii promoterGO:006063330.016
morphogenesis of an epitheliumGO:0002009600.016
gland developmentGO:0048732480.016
tissue regenerationGO:004224630.016
response to transforming growth factor betaGO:0071559940.016
protein autophosphorylationGO:00467771230.016
regulation of intracellular protein transportGO:00331571230.016
sensory perception of smellGO:000760820.016

NPAS2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.048
disease of metabolismDOID:00146672950.030
nervous system diseaseDOID:8634310.026
sensory system diseaseDOID:00501552030.026
connective tissue diseaseDOID:651090.023
disease of cellular proliferationDOID:145661740.022
cancerDOID:1621670.022
organ system cancerDOID:00506861640.022
bone diseaseDOID:0080001880.020
inherited metabolic disorderDOID:6552420.019
central nervous system diseaseDOID:3311860.019
eye diseaseDOID:56141490.018
eye and adnexa diseaseDOID:14921500.018
cardiovascular system diseaseDOID:12871060.017