IMP: Integrative Multi-species Prediction

Homo sapiens

43 known processes

NTHL1

nth endonuclease III-like 1 (E. coli)

(Aliases: NTH1,OCTS3)

Ensembl: ENSG00000065057
MIM: 602656
HGNC: 8028
HPRD: 04039
Entrez: 4913
UniProtKB: P78549
UniProtKB: E5KTI5

Process Predictions
Disease Predictions

NTHL1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
purine nucleoside monophosphate catabolic process	GO:0009128	158	0.289
organophosphate catabolic process	GO:0046434	430	0.282
guanosine containing compound metabolic process	GO:1901068	244	0.277
nucleoside phosphate catabolic process	GO:1901292	412	0.239
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.233
nucleoside monophosphate metabolic process	GO:0009123	191	0.215
purine ribonucleoside metabolic process	GO:0046128	437	0.163
purine containing compound catabolic process	GO:0072523	411	0.163
atp catabolic process	GO:0006200	157	0.151
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.149
nucleoside triphosphate metabolic process	GO:0009141	422	0.143
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.141
purine ribonucleoside monophosphate metabolic process	GO:0009167	186	0.129
purine ribonucleoside monophosphate catabolic process	GO:0009169	158	0.127
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.125
purine nucleoside catabolic process	GO:0006152	398	0.122
ribonucleotide catabolic process	GO:0009261	405	0.120
nucleoside catabolic process	GO:0009164	408	0.112
nucleoside monophosphate catabolic process	GO:0009125	159	0.109
ribonucleoside catabolic process	GO:0042454	406	0.105
ribonucleoside monophosphate catabolic process	GO:0009158	158	0.103
nucleoside triphosphate catabolic process	GO:0009143	394	0.103
atp metabolic process	GO:0046034	176	0.102
glycosyl compound catabolic process	GO:1901658	413	0.101
post embryonic development	GO:0009791	2	0.096
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.091
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.090
nucleotide catabolic process	GO:0009166	408	0.085
purine ribonucleotide catabolic process	GO:0009154	404	0.084
purine ribonucleoside catabolic process	GO:0046130	398	0.079
gtp catabolic process	GO:0006184	237	0.077
ribonucleoside monophosphate metabolic process	GO:0009161	187	0.075
purine nucleoside monophosphate metabolic process	GO:0009126	186	0.066
ncrna metabolic process	GO:0034660	108	0.064
cellular amino acid metabolic process	GO:0006520	116	0.063
deoxyribose phosphate metabolic process	GO:0019692	6	0.061
gtp metabolic process	GO:0046039	239	0.060
guanosine containing compound catabolic process	GO:1901069	239	0.059
fatty acid metabolic process	GO:0006631	115	0.047
dna repair	GO:0006281	198	0.047
trna metabolic process	GO:0006399	35	0.042
regulation of cellular amino acid metabolic process	GO:0006521	6	0.041
cellular ketone metabolic process	GO:0042180	80	0.040
lipid metabolic process	GO:0006629	381	0.035
cellular amine metabolic process	GO:0044106	41	0.033
regulation of cellular ketone metabolic process	GO:0010565	50	0.033
mitochondrion organization	GO:0007005	156	0.033
multicellular organismal aging	GO:0010259	3	0.031
positive regulation of cellular amine metabolic process	GO:0033240	7	0.029
nucleic acid phosphodiester bond hydrolysis	GO:0090305	102	0.028
cellular lipid metabolic process	GO:0044255	303	0.028
2 deoxyribonucleotide metabolic process	GO:0009394	6	0.028
regulation of cellular amine metabolic process	GO:0033238	11	0.027
nervous system development	GO:0007399	293	0.027
amine metabolic process	GO:0009308	44	0.027
dna replication	GO:0006260	116	0.026
establishment or maintenance of cytoskeleton polarity	GO:0030952	3	0.026
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.025
cellular macromolecule catabolic process	GO:0044265	380	0.025
mitochondrial rna metabolic process	GO:0000959	15	0.025
ribonucleoprotein complex subunit organization	GO:0071826	81	0.025
rna processing	GO:0006396	255	0.024
organophosphate biosynthetic process	GO:0090407	163	0.024
chromatin organization	GO:0006325	351	0.023
ncrna processing	GO:0034470	83	0.022
regulation of purine nucleotide metabolic process	GO:1900542	264	0.021
trna processing	GO:0008033	23	0.020
lipid biosynthetic process	GO:0008610	177	0.020
female gamete generation	GO:0007292	2	0.020
cellular response to dna damage stimulus	GO:0006974	379	0.020
positive regulation of developmental process	GO:0051094	314	0.020
negative regulation of cell cycle	GO:0045786	193	0.020
cell development	GO:0048468	328	0.020
regulation of nucleotide metabolic process	GO:0006140	269	0.019
nucleotide biosynthetic process	GO:0009165	109	0.019
histone modification	GO:0016570	251	0.019
monocarboxylic acid metabolic process	GO:0032787	185	0.019
rna phosphodiester bond hydrolysis	GO:0090501	35	0.018
regulation of cytoskeleton organization	GO:0051493	177	0.018
response to oxygen containing compound	GO:1901700	369	0.018
chemical homeostasis	GO:0048878	306	0.018
sulfate transmembrane transport	GO:1902358	3	0.017
organelle fission	GO:0048285	149	0.017
organonitrogen compound biosynthetic process	GO:1901566	200	0.017
positive regulation of cellular component organization	GO:0051130	376	0.017
carbohydrate derivative biosynthetic process	GO:1901137	207	0.017
peptidyl tyrosine phosphorylation	GO:0018108	170	0.017
regulation of cell growth	GO:0001558	135	0.016
cellular component morphogenesis	GO:0032989	314	0.016
spermatid development	GO:0007286	4	0.016
purine nucleotide catabolic process	GO:0006195	405	0.016
regulation of dna metabolic process	GO:0051052	153	0.016
rho protein signal transduction	GO:0007266	26	0.016
immune system development	GO:0002520	195	0.016
microtubule based process	GO:0007017	210	0.016
regulation of transferase activity	GO:0051338	355	0.016
cellular macromolecular complex assembly	GO:0034622	324	0.016
negative regulation of cell death	GO:0060548	345	0.016
apoptotic signaling pathway	GO:0097190	268	0.016
neurogenesis	GO:0022008	169	0.016
negative regulation of cellular protein metabolic process	GO:0032269	353	0.015
protein localization to organelle	GO:0033365	280	0.015
cellular response to extracellular stimulus	GO:0031668	72	0.015
ras protein signal transduction	GO:0007265	73	0.015
immune effector process	GO:0002252	159	0.014
purine containing compound biosynthetic process	GO:0072522	88	0.014
trna wobble uridine modification	GO:0002098	3	0.014
determination of adult lifespan	GO:0008340	2	0.014
negative regulation of catalytic activity	GO:0043086	335	0.014
protein oligomerization	GO:0051259	173	0.014
ribonucleoprotein complex biogenesis	GO:0022613	116	0.014
immune response	GO:0006955	307	0.014
nucleoside phosphate biosynthetic process	GO:1901293	109	0.014
cofactor catabolic process	GO:0051187	7	0.014
cell growth	GO:0016049	160	0.014
response to virus	GO:0009615	126	0.014
negative regulation of phosphorus metabolic process	GO:0010563	267	0.014
posttranscriptional regulation of gene expression	GO:0010608	213	0.014
regulation of epithelial cell proliferation	GO:0050678	113	0.013
mrna metabolic process	GO:0016071	175	0.013
neuromuscular junction development	GO:0007528	3	0.013
response to abiotic stimulus	GO:0009628	336	0.013
cellular component disassembly	GO:0022411	92	0.013
spermatid differentiation	GO:0048515	4	0.013
positive regulation of dna metabolic process	GO:0051054	73	0.013
negative regulation of cellular component organization	GO:0051129	235	0.013
positive regulation of hydrolase activity	GO:0051345	331	0.013
maintenance of location	GO:0051235	112	0.013
cell morphogenesis	GO:0000902	296	0.013
negative regulation of phosphate metabolic process	GO:0045936	267	0.013
transcription from mitochondrial promoter	GO:0006390	7	0.013
small gtpase mediated signal transduction	GO:0007264	78	0.013
organic acid biosynthetic process	GO:0016053	97	0.012
segmentation	GO:0035282	4	0.012
regulation of intracellular transport	GO:0032386	195	0.012
vesicle mediated transport	GO:0016192	371	0.012
membrane organization	GO:0061024	292	0.012
positive regulation of transport	GO:0051050	336	0.012
regulation of cell development	GO:0060284	161	0.012
purine deoxyribonucleoside triphosphate metabolic process	GO:0009215	4	0.012
sulfur compound metabolic process	GO:0006790	101	0.012
negative regulation of apoptotic process	GO:0043066	316	0.012
developmental programmed cell death	GO:0010623	3	0.012
ribonucleotide biosynthetic process	GO:0009260	81	0.012
oogenesis	GO:0048477	2	0.012
metencephalon development	GO:0022037	2	0.012
protein alkylation	GO:0008213	74	0.012
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.012
cytoplasmic transport	GO:0016482	379	0.012
protein ubiquitination	GO:0016567	314	0.012
covalent chromatin modification	GO:0016569	254	0.011
negative regulation of developmental process	GO:0051093	247	0.011
single organism cellular localization	GO:1902580	332	0.011
deoxyribose phosphate catabolic process	GO:0046386	5	0.011
response to nitrogen compound	GO:1901698	184	0.011
positive regulation of organelle organization	GO:0010638	195	0.011
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.011
positive regulation of catabolic process	GO:0009896	310	0.011
protein processing	GO:0016485	226	0.011
negative regulation of protein metabolic process	GO:0051248	391	0.011
positive regulation of intracellular transport	GO:0032388	104	0.011
epithelium development	GO:0060429	227	0.011
regulation of cell cycle process	GO:0010564	266	0.011
carboxylic acid biosynthetic process	GO:0046394	97	0.011
dna dealkylation	GO:0035510	13	0.011
positive regulation of cell differentiation	GO:0045597	211	0.011
regulation of growth	GO:0040008	165	0.011
negative regulation of programmed cell death	GO:0043069	321	0.011
response to cytokine	GO:0034097	232	0.011
purine deoxyribonucleotide catabolic process	GO:0009155	4	0.011
regulation of apoptotic signaling pathway	GO:2001233	175	0.011
dna catabolic process endonucleolytic	GO:0000737	37	0.011
meiosis i	GO:0007127	4	0.011
regulation of immune response	GO:0050776	201	0.011
cell projection organization	GO:0030030	252	0.011
protein homooligomerization	GO:0051260	100	0.011
metallo sulfur cluster assembly	GO:0031163	8	0.010
positive regulation of cellular component movement	GO:0051272	181	0.010
deoxyribonucleotide metabolic process	GO:0009262	6	0.010
hemopoiesis	GO:0030097	180	0.010
ribonucleoprotein complex assembly	GO:0022618	78	0.010
regulation of cell differentiation	GO:0045595	393	0.010
negative regulation of multicellular organismal process	GO:0051241	317	0.010
embryo development	GO:0009790	123	0.010
cellular response to external stimulus	GO:0071496	111	0.010
circulatory system development	GO:0072359	262	0.010
growth	GO:0040007	202	0.010
response to organic cyclic compound	GO:0014070	204	0.010
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.010
negative regulation of transferase activity	GO:0051348	124	0.010
protein modification by small protein conjugation	GO:0032446	342	0.010
cell part morphogenesis	GO:0032990	137	0.010
epithelial cell differentiation	GO:0030855	141	0.010

NTHL1 disease predictions

Disease	DO term ID	Size	Probability
disease of cellular proliferation	DOID:14566	174	0.028
disease of metabolism	DOID:0014667	295	0.026
organ system cancer	DOID:0050686	164	0.024
cancer	DOID:162	167	0.024
inherited metabolic disorder	DOID:655	242	0.017
retinal disease	DOID:5679	118	0.013
nervous system disease	DOID:863	431	0.013
eye and adnexa disease	DOID:1492	150	0.013
sensory system disease	DOID:0050155	203	0.013
retinal degeneration	DOID:8466	89	0.013
eye disease	DOID:5614	149	0.013
musculoskeletal system disease	DOID:17	223	0.013
connective tissue disease	DOID:65	109	0.013

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network