Homo sapiens

78 known processes

NPC1

Niemann-Pick disease, type C1

(Aliases: NPC,FLJ98532)

NPC1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
lipid metabolic processGO:00066293810.131
Human Mouse Fly
cellular lipid metabolic processGO:00442553030.089
post embryonic developmentGO:000979120.077
Worm Fly
organophosphate catabolic processGO:00464344300.073
determination of adult lifespanGO:000834020.071
chemical homeostasisGO:00488783060.068
cellular amine metabolic processGO:0044106410.067
transmembrane transportGO:00550853990.067
multicellular organismal agingGO:001025930.064
purine containing compound catabolic processGO:00725234110.063
cellular ketone metabolic processGO:0042180800.060
Fly
membrane organizationGO:00610242920.060
purine ribonucleoside metabolic processGO:00461284370.060
ribonucleotide catabolic processGO:00092614050.059
nucleoside catabolic processGO:00091644080.059
glycosyl compound catabolic processGO:19016584130.059
nucleoside triphosphate metabolic processGO:00091414220.058
amine metabolic processGO:0009308440.057
ribonucleoside catabolic processGO:00424544060.055
purine nucleoside triphosphate catabolic processGO:00091463920.054
nucleoside phosphate catabolic processGO:19012924120.053
purine ribonucleoside triphosphate catabolic processGO:00092073910.053
female gamete generationGO:000729220.052
nucleotide catabolic processGO:00091664080.051
purine nucleotide catabolic processGO:00061954050.051
purine ribonucleoside catabolic processGO:00461303980.051
regulation of cellular amino acid metabolic processGO:000652160.050
nucleoside triphosphate catabolic processGO:00091433940.049
regulation of cellular amine metabolic processGO:0033238110.049
regulation of cellular ketone metabolic processGO:0010565500.049
ribonucleoside triphosphate metabolic processGO:00091994120.047
anion transportGO:00068201610.047
purine ribonucleotide catabolic processGO:00091544040.046
response to abiotic stimulusGO:00096283360.045
ribonucleoside triphosphate catabolic processGO:00092033910.045
purine ribonucleoside triphosphate metabolic processGO:00092054110.044
vesicle mediated transportGO:00161923710.043
Mouse
lipid biosynthetic processGO:00086101770.043
Human Fly
cellular amino acid metabolic processGO:00065201160.043
cation transportGO:00068123310.042
inorganic ion transmembrane transportGO:00986602310.041
positive regulation of transportGO:00510503360.040
single organism cellular localizationGO:19025803320.040
immune responseGO:00069553070.040
cellular macromolecule catabolic processGO:00442653800.040
oogenesisGO:004847720.039
cell developmentGO:00484683280.038
Fly
defense responseGO:00069523150.038
purine nucleoside triphosphate metabolic processGO:00091444120.038
ion transmembrane transportGO:00342203380.037
cytoplasmic transportGO:00164823790.036
ion homeostasisGO:00508012300.034
endomembrane system organizationGO:00102561960.034
negative regulation of catalytic activityGO:00430863350.034
locomotory behaviorGO:000762610.034
Mouse
positive regulation of cellular amine metabolic processGO:003324070.034
protein localization to organelleGO:00333652800.033
protein catabolic processGO:00301633250.033
nervous system developmentGO:00073992930.032
growthGO:00400072020.032
Worm
organic hydroxy compound metabolic processGO:19016151470.032
Human Mouse Fly
regulation of transferase activityGO:00513383550.031
regulation of cell differentiationGO:00455953930.031
single organism membrane organizationGO:00448022680.031
positive regulation of cellular amino acid metabolic processGO:004576430.031
cation transmembrane transportGO:00986552380.031
lipid localizationGO:00108761060.031
cellular protein catabolic processGO:00442572610.031
positive regulation of cellular catabolic processGO:00313312840.031
dephosphorylationGO:00163112090.031
positive regulation of hydrolase activityGO:00513453310.031
guanosine containing compound catabolic processGO:19010692390.030
cellular response to endogenous stimulusGO:00714953360.030
Mouse
system processGO:00030083490.030
Human
purine nucleoside catabolic processGO:00061523980.030
proteolysis involved in cellular protein catabolic processGO:00516032440.029
intracellular protein transportGO:00068862700.029
inorganic cation transmembrane transportGO:00986621940.029
cellular cation homeostasisGO:00300031630.029
negative regulation of cellular protein metabolic processGO:00322693530.029
cell morphogenesisGO:00009022960.029
gtp metabolic processGO:00460392390.029
negative regulation of phosphorus metabolic processGO:00105632670.029
cellular component morphogenesisGO:00329893140.028
regulation of cell cycleGO:00517263930.028
ras protein signal transductionGO:0007265730.028
mitotic cell cycleGO:00002783260.028
cellular ion homeostasisGO:00068731680.028
positive regulation of catabolic processGO:00098963100.028
cellular homeostasisGO:00197251960.028
biological adhesionGO:00226103310.028
negative regulation of protein metabolic processGO:00512483910.027
organic anion transportGO:00157111030.027
metal ion transportGO:00300012720.027
response to oxygen containing compoundGO:19017003690.027
cell projection organizationGO:00300302520.027
endosomal transportGO:00161971290.027
secretionGO:00469032540.026
cellular macromolecular complex assemblyGO:00346223240.026
steroid metabolic processGO:0008202940.026
Human Mouse Fly
cation homeostasisGO:00550801890.026
organonitrogen compound biosynthetic processGO:19015662000.026
small molecule biosynthetic processGO:00442831570.026
Human Fly
guanosine containing compound metabolic processGO:19010682440.026
small gtpase mediated signal transductionGO:0007264780.026
regulation of protein localizationGO:00328802960.026
regulation of kinase activityGO:00435493140.025
rho protein signal transductionGO:0007266260.025
regulation of cellular component movementGO:00512703340.025
negative regulation of apoptotic processGO:00430663160.025
regulation of nucleotide metabolic processGO:00061402690.025
secretion by cellGO:00329402260.025
monocarboxylic acid metabolic processGO:00327871850.025
Mouse
metal ion homeostasisGO:00550651690.025
cellular chemical homeostasisGO:00550821800.025
lipid transportGO:0006869900.025
maintenance of locationGO:00512351120.024
glycerolipid metabolic processGO:00464861070.024
positive regulation of cellular component organizationGO:00511303760.024
regulation of immune responseGO:00507762010.024
regulation of anatomical structure morphogenesisGO:00226032860.023
cytokine productionGO:00018162470.023
neurological system processGO:00508771630.023
oocyte differentiationGO:000999420.023
regulation of protein kinase activityGO:00458592890.023
cellular response to nitrogen compoundGO:19016991440.023
cellular response to dna damage stimulusGO:00069743790.023
actin filament based processGO:00300292240.023
protein processingGO:00164852260.023
response to organonitrogen compoundGO:00102431560.023
negative regulation of programmed cell deathGO:00430693210.023
signal transduction by phosphorylationGO:00230142970.022
regulation of secretionGO:00510461940.022
positive regulation of cell deathGO:00109422630.022
anatomical structure formation involved in morphogenesisGO:00486462840.022
Fly
organelle assemblyGO:00709251760.022
memoryGO:000761330.022
positive regulation of phosphorylationGO:00423273940.022
regulation of cell motilityGO:20001452990.022
carbohydrate derivative biosynthetic processGO:19011372070.022
ubiquitin dependent protein catabolic processGO:00065112060.022
cell adhesionGO:00071553250.022
positive regulation of nucleoside metabolic processGO:00459791860.021
negative regulation of hydrolase activityGO:00513461820.021
regulation of proteolysisGO:00301622930.021
neurotransmitter secretionGO:000726940.021
lipid modificationGO:0030258840.021
regulation of purine nucleotide metabolic processGO:19005422640.021
negative regulation of phosphate metabolic processGO:00459362670.021
positive regulation of purine nucleotide metabolic processGO:19005442270.021
positive regulation of nucleotide catabolic processGO:00308131850.021
regulation of cell cycle processGO:00105642660.021
membrane lipid metabolic processGO:0006643530.021
segmentationGO:003528240.021
gtp catabolic processGO:00061842370.021
negative regulation of cell deathGO:00605483450.020
regulation of cell migrationGO:00303342890.020
regulation of cellular response to stressGO:00801352440.020
Mouse
response to nitrogen compoundGO:19016981840.020
cellular response to oxygen containing compoundGO:19017012760.020
regulation of purine nucleotide catabolic processGO:00331212050.020
adult locomotory behaviorGO:000834410.020
Mouse
regulation of cellular component biogenesisGO:00440872810.020
modification dependent macromolecule catabolic processGO:00436322120.020
innate immune responseGO:00450871780.020
regulation of nucleoside metabolic processGO:00091182090.020
positive regulation of developmental processGO:00510943140.020
motor neuron axon guidanceGO:000804520.020
protein ubiquitinationGO:00165673140.019
protein maturationGO:00516042330.019
negative regulation of intracellular signal transductionGO:19025321830.019
neuromuscular junction developmentGO:000752830.019
purine nucleoside monophosphate metabolic processGO:00091261860.019
cellular protein complex assemblyGO:00436231880.019
immune system developmentGO:00025201950.019
protein oligomerizationGO:00512591730.019
negative regulation of cellular component organizationGO:00511292350.019
positive regulation of immune system processGO:00026842830.019
neurogenesisGO:00220081690.019
modification dependent protein catabolic processGO:00199412090.019
organic acid biosynthetic processGO:0016053970.019
atp catabolic processGO:00062001570.019
monovalent inorganic cation transportGO:00156721280.019
atp metabolic processGO:00460341760.019
phospholipid metabolic processGO:0006644990.019
regulation of growthGO:00400081650.019
Worm
positive regulation of purine nucleotide catabolic processGO:00331231850.019
mitotic cell cycle processGO:19030472860.019
regenerationGO:003109940.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
cell growthGO:00160491600.019
positive regulation of nucleotide metabolic processGO:00459812300.018
protein homooligomerizationGO:00512601000.018
organophosphate biosynthetic processGO:00904071630.018
microtubule based processGO:00070172100.018
oocyte developmentGO:004859910.018
ribonucleoside monophosphate metabolic processGO:00091611870.018
apoptotic signaling pathwayGO:00971902680.018
nitrogen compound transportGO:00717051910.018
regulation of vesicle mediated transportGO:00606271300.018
negative regulation of transportGO:00510511760.018
fatty acid metabolic processGO:00066311150.018
regulation of establishment of protein localizationGO:00702012420.018
regulation of nucleotide catabolic processGO:00308112050.018
carboxylic acid biosynthetic processGO:0046394970.018
circadian behaviorGO:004851220.018
protein targetingGO:00066051870.018
negative regulation of multicellular organismal processGO:00512413170.018
regulation of cell growthGO:00015581350.017
regulation of peptidase activityGO:00525471800.017
regulation of gtp catabolic processGO:00331241800.017
negative regulation of protein modification processGO:00314002000.017
negative regulation of cellular amine metabolic processGO:003323930.017
positive regulation of gtp catabolic processGO:00331261660.017
regulation of response to external stimulusGO:00321012220.017
Mouse
regulation of endopeptidase activityGO:00525481700.017
protein localization to membraneGO:00726571600.017
regulation of secretion by cellGO:19035301770.017
regulation of cytokine productionGO:00018172320.017
activation of immune responseGO:00022531140.017
carbohydrate metabolic processGO:00059752070.017
enzyme linked receptor protein signaling pathwayGO:00071673030.017
purine ribonucleoside monophosphate catabolic processGO:00091691580.017
nucleoside monophosphate metabolic processGO:00091231910.017
regulation of locomotionGO:00400123290.017
generation of neuronsGO:00486991520.017
protein modification by small protein conjugationGO:00324463420.017
immune effector processGO:00022521590.017
positive regulation of programmed cell deathGO:00430682490.017
glycerophospholipid metabolic processGO:0006650840.017
cellular metal ion homeostasisGO:00068751460.017
positive regulation of gtpase activityGO:00435471660.017
peripheral nervous system developmentGO:000742220.017
actin cytoskeleton organizationGO:00300362070.017
regulation of mitotic cell cycleGO:00073461890.016
regulation of defense responseGO:00313471540.016
positive regulation of secretionGO:00510471160.016
cell activationGO:00017752130.016
mitotic cell cycle phase transitionGO:00447721620.016
positive regulation of secretion by cellGO:19035321080.016
cell divisionGO:00513011680.016
proteasomal protein catabolic processGO:00104981760.016
response to hormoneGO:00097251750.016
Mouse
blastoderm segmentationGO:000735020.016
establishment of protein localization to organelleGO:00725941720.016
cell cycle phase transitionGO:00447701730.016
cellular response to hormone stimulusGO:00328701250.016
Mouse
cellular divalent inorganic cation homeostasisGO:00725031280.016
regulation of multi organism processGO:00439001570.015
Worm
regulation of protein transportGO:00512232130.015
positive regulation of apoptotic processGO:00430652460.015
positive regulation of cell proliferationGO:00082843010.015
peptidyl tyrosine phosphorylationGO:00181081700.015
rhythmic behaviorGO:000762220.015
positive regulation of protein phosphorylationGO:00019343130.015
posttranscriptional regulation of gene expressionGO:00106082130.015
interspecies interaction between organismsGO:00444191560.015
organic hydroxy compound transportGO:0015850630.015
regulation of mapk cascadeGO:00434082620.015
regulation of gtpase activityGO:00430871800.015
single organism carbohydrate metabolic processGO:00447231930.015
oxidation reduction processGO:00551143960.015
nucleoside monophosphate catabolic processGO:00091251590.015
cell cell signalingGO:00072671550.015
protein modification by small protein removalGO:0070646920.015
regulation of reactive oxygen species biosynthetic processGO:190342630.015
positive regulation of kinase activityGO:00336742040.015
matingGO:000761810.015
glycoprotein metabolic processGO:00091001100.014
regulation of small gtpase mediated signal transductionGO:00510561560.014
lipid catabolic processGO:0016042840.014
regulation of apoptotic signaling pathwayGO:20012331750.014
syncytium formation by plasma membrane fusionGO:000076820.014
purine ribonucleoside monophosphate metabolic processGO:00091671860.014
protein deubiquitinationGO:0016579790.014
establishment of protein localization to membraneGO:00901501210.014
mapk cascadeGO:00001652880.014
cell part morphogenesisGO:00329901370.014
reactive oxygen species biosynthetic processGO:190340940.014
morphogenesis of embryonic epitheliumGO:001633140.014
ribonucleoside monophosphate catabolic processGO:00091581580.014
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.014
regulation of protein catabolic processGO:00421761550.014
microtubule cytoskeleton organizationGO:00002261760.014
regulation of neurotransmitter secretionGO:004692830.014
cellular response to starvationGO:0009267580.014
Mouse
negative regulation of cell proliferationGO:00082852280.014
response to oxidative stressGO:00069791210.014
negative regulation of cell cycleGO:00457861930.014
regulation of synaptic plasticityGO:004816730.014
reactive nitrogen species metabolic processGO:200105730.014
response to external biotic stimulusGO:00432072610.014
regulation of protein maturationGO:19033171500.014
positive regulation of cytokine productionGO:00018191670.014
regulation of syncytium formation by plasma membrane fusionGO:006014220.014
regulation of membrane potentialGO:0042391950.014
hemopoiesisGO:00300971800.014
response to cytokineGO:00340972320.014
epithelial cell differentiationGO:00308551410.014
positive regulation of protein kinase activityGO:00458601900.014
response to decreased oxygen levelsGO:0036293960.014
hindbrain developmentGO:003090230.014
positive regulation of synaptic transmissionGO:005080640.013
regulation of protein processingGO:00706131500.013
spermatid differentiationGO:004851540.013
Fly
response to hypoxiaGO:0001666960.013
positive regulation of transferase activityGO:00513472270.013
regulation of cell adhesionGO:00301551660.013
negative regulation of phosphorylationGO:00423261740.013
cellular lipid catabolic processGO:0044242650.013
cytokinesisGO:0000910960.013
autophagyGO:0006914880.013
wnt signaling pathwayGO:00160551560.013
alcohol metabolic processGO:00060661140.013
Human Fly
leukocyte activationGO:00453211640.013
visual behaviorGO:000763220.013
symbiosis encompassing mutualism through parasitismGO:00444031560.013
regulation of cell developmentGO:00602841610.013
nerve developmentGO:002167540.013
plasma membrane organizationGO:00070091150.013
organic hydroxy compound biosynthetic processGO:1901617710.013
Human
cell morphogenesis involved in differentiationGO:00009041440.013
regulation of protein serine threonine kinase activityGO:00719001790.013
photoreceptor cell differentiationGO:004653020.013
cell projection morphogenesisGO:00488581290.013
exocytosisGO:0006887710.013
sphingolipid metabolic processGO:0006665380.013
regulation of ras protein signal transductionGO:00465781550.013
negative regulation of organelle organizationGO:00106391260.013
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.013
positive regulation of cell migrationGO:00303351720.013
regulation of protein complex assemblyGO:00432541470.013
positive regulation of ras gtpase activityGO:00323201170.013
negative regulation of protein processingGO:00109551420.013
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.012
i kappab kinase nf kappab signalingGO:00072491660.012
mitochondrion organizationGO:00070051560.012
rab protein signal transductionGO:003248240.012
response to oxygen levelsGO:00704821000.012
compound eye developmentGO:004874910.012
peptidyl tyrosine modificationGO:00182121700.012
neuron developmentGO:00486661130.012
nuclear transportGO:00511691790.012
single organism reproductive processGO:0044702980.012
Fly
monocarboxylic acid biosynthetic processGO:0072330670.012
embryonic epithelial tube formationGO:000183840.012
neural tube formationGO:000184130.012
small molecule catabolic processGO:0044282920.012
cellular response to external stimulusGO:00714961110.012
Mouse
rna processingGO:00063962550.012
response to other organismGO:00517072610.012
neuroblast proliferationGO:000740540.012
regulation of intracellular transportGO:00323861950.012
nucleocytoplasmic transportGO:00069131760.012
positive regulation of immune responseGO:00507781590.012
neuron differentiationGO:00301821380.012
regulation of cell cycle phase transitionGO:19019871260.012
positive regulation of cell differentiationGO:00455972110.012
intrinsic apoptotic signaling pathwayGO:00971931270.012
chromatin organizationGO:00063253510.012
organelle fissionGO:00482851490.012
single organism cell adhesionGO:00986021790.012
negative regulation of cell cycle processGO:00109481210.012
regulation of ras gtpase activityGO:00323181280.012
response to extracellular stimulusGO:0009991850.012
Mouse
regulation of ion transportGO:00432691890.012
divalent inorganic cation homeostasisGO:00725071360.012
head developmentGO:00603221080.012
response to woundingGO:00096111680.012
regulation of cytoskeleton organizationGO:00514931770.012
organic acid transportGO:0015849650.012
regulation of cell projection organizationGO:00313441070.012
epithelium developmentGO:00604292270.012
hematopoietic or lymphoid organ developmentGO:00485341860.011
response to organic cyclic compoundGO:00140702040.011
Mouse
regulation of leukocyte activationGO:00026941150.011
positive regulation of locomotionGO:00400171860.011
negative regulation of growthGO:0045926970.011
golgi vesicle transportGO:0048193800.011
regulation of hormone levelsGO:00108171250.011
Fly
cell cycle checkpointGO:00000751170.011
tripartite regional subdivisionGO:000735120.011
spermatid developmentGO:000728640.011
Fly
regulation of neural precursor cell proliferationGO:200017740.011
tissue regenerationGO:004224630.011
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.011
associative learningGO:000830610.011
cardiac muscle cell contractionGO:008600340.011
establishment or maintenance of apical basal cell polarityGO:003508820.011
transmission of nerve impulseGO:0019226110.011
negative regulation of protein phosphorylationGO:00019331400.011
response to virusGO:00096151260.011
response to starvationGO:0042594590.011
Mouse
negative regulation of immune system processGO:00026831360.011
immune response regulating signaling pathwayGO:0002764970.011
cellular response to organonitrogen compoundGO:00714171240.011
response to peptideGO:1901652650.011
regulation of dephosphorylationGO:0035303960.011
dna repairGO:00062811980.011
anterior posterior axis specification embryoGO:000859520.011
chemotaxisGO:00069351570.011
cellular response to nutrient levelsGO:0031669690.011
Mouse
cell fate determinationGO:000170930.011
endocytosisGO:00068971590.011
Mouse
response to radiationGO:00093141510.011
regulation of cysteine type endopeptidase activityGO:20001161270.011
negative regulation of transferase activityGO:00513481240.011
primary neural tube formationGO:001402030.011
single organismal cell cell adhesionGO:00163371480.011
negative regulation of proteolysisGO:00458611320.011
immune response activating signal transductionGO:0002757900.011
rna interferenceGO:001624640.011
lymphocyte activationGO:00466491330.011
regulation of intracellular protein transportGO:00331571230.011
regulation of cytoplasmic transportGO:19036491490.011
regulation of axon guidanceGO:190266730.011
defense response to other organismGO:00985421290.011
negative regulation of protein maturationGO:19033181420.011
reproductive processGO:00224141060.011
Worm Fly
multi organism cellular processGO:00447641560.011
positive regulation of protein transportGO:00512221350.011
response to inorganic substanceGO:00100351270.011
anion transmembrane transportGO:0098656760.011
regulation of bindingGO:00510981110.010
morphogenesis of a polarized epitheliumGO:000173830.010
positive regulation of cellular component movementGO:00512721810.010
positive regulation of protein serine threonine kinase activityGO:00719021190.010
response to axon injuryGO:004867810.010
carboxylic acid transportGO:0046942630.010
response to biotic stimulusGO:00096072760.010
protein importGO:00170381300.010
regulation of wnt signaling pathwayGO:00301111230.010
anterior posterior axis specificationGO:000994820.010
negative regulation of kinase activityGO:00336731060.010
covalent chromatin modificationGO:00165692540.010
metencephalon developmentGO:002203720.010
regulation of neurogenesisGO:0050767820.010
regulation of mitotic cell cycle phase transitionGO:19019901180.010
taxisGO:00423301570.010
embryo developmentGO:00097901230.010
Worm
negative regulation of developmental processGO:00510932470.010
cerebral cortex cell migrationGO:002179530.010
positive regulation of organelle organizationGO:00106381950.010
tube closureGO:006060630.010
protein localization to nucleusGO:00345041360.010
sulfur compound metabolic processGO:00067901010.010
cerebellum developmentGO:002154920.010
limbic system developmentGO:002176130.010
meiosis iGO:000712740.010
glycoprotein biosynthetic processGO:0009101910.010
regulation of homeostatic processGO:00328441210.010
negative regulation of protein kinase activityGO:0006469980.010
cardiovascular system developmentGO:00723582620.010
meiotic chromosome segregationGO:004513240.010
regulation of anatomical structure sizeGO:00900661010.010

NPC1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.029
inherited metabolic disorderDOID:6552420.029
central nervous system diseaseDOID:3311860.028
nervous system diseaseDOID:8634310.028
organ system cancerDOID:00506861640.021
disease of cellular proliferationDOID:145661740.021
cancerDOID:1621670.021
sensory system diseaseDOID:00501552030.018
musculoskeletal system diseaseDOID:172230.017
eye diseaseDOID:56141490.015
eye and adnexa diseaseDOID:14921500.015
neuropathyDOID:870520.013
immune system diseaseDOID:29141550.012
retinal diseaseDOID:56791180.012
connective tissue diseaseDOID:651090.012
bone diseaseDOID:0080001880.012
neurodegenerative diseaseDOID:12891020.012
brain diseaseDOID:936730.011
lysosomal storage diseaseDOID:3211470.006
lipid storage diseaseDOID:9455280.004
sphingolipidosisDOID:1927140.002
lymphatic system diseaseDOID:75120.002
histiocytosisDOID:340540.001
non langerhans cell histiocytosisDOID:433040.001
niemann pick diseaseDOID:1450430.001