Homo sapiens

122 known processes

CHEK1

CHK1 checkpoint homolog (S. pombe)

(Aliases: CHK1)

CHEK1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to dna damage stimulusGO:00069743791.000
g2 dna damage checkpointGO:0031572260.999
dna damage checkpointGO:0000077680.999
dna repairGO:00062811980.998
regulation of cell cycle phase transitionGO:19019871260.998
Zebrafish Rat
regulation of cell cycleGO:00517263930.998
cell cycle phase transitionGO:00447701730.997
Zebrafish Mouse Rat
double strand break repairGO:00063021010.996
dna integrity checkpointGO:0031570710.995
double strand break repair via homologous recombinationGO:0000724500.993
negative regulation of mitotic cell cycle phase transitionGO:1901991850.992
Zebrafish Rat
meiosis iGO:000712740.988
regulation of cell cycle processGO:00105642660.982
response to radiationGO:00093141510.979
Mouse
mitotic dna damage checkpointGO:0044773280.974
Zebrafish
negative regulation of mitotic cell cycleGO:00459301020.973
cellular macromolecule catabolic processGO:00442653800.972
mitotic cell cycle phase transitionGO:00447721620.962
Zebrafish Mouse Rat
negative regulation of cell cycle phase transitionGO:1901988890.953
Zebrafish Rat
mitotic dna integrity checkpointGO:0044774300.952
Zebrafish
purine nucleoside monophosphate metabolic processGO:00091261860.947
mitotic cell cycleGO:00002783260.944
meiotic nuclear divisionGO:0007126100.941
negative regulation of cell cycleGO:00457861930.935
dna catabolic processGO:0006308490.931
cell cycle checkpointGO:00000751170.928
apoptotic signaling pathwayGO:00971902680.921
Zebrafish
negative regulation of cell cycle processGO:00109481210.916
regulation of mitotic cell cycleGO:00073461890.907
regulation of mitotic cell cycle phase transitionGO:19019901180.904
Zebrafish Rat
cellular response to radiationGO:0071478650.896
Mouse
ribonucleoside monophosphate metabolic processGO:00091611870.887
mitotic cell cycle processGO:19030472860.887
regulation of response to dna damage stimulusGO:2001020940.883
purine ribonucleoside monophosphate catabolic processGO:00091691580.866
modification dependent protein catabolic processGO:00199412090.853
negative regulation of dna metabolic processGO:0051053570.824
Rat
recombinational repairGO:0000725500.795
nucleoside triphosphate metabolic processGO:00091414220.786
response to ionizing radiationGO:0010212650.782
regulation of double strand break repair via homologous recombinationGO:0010569110.775
ribonucleoside monophosphate catabolic processGO:00091581580.770
atp metabolic processGO:00460341760.758
ribonucleoside triphosphate catabolic processGO:00092033910.731
response to abiotic stimulusGO:00096283360.723
female gamete generationGO:000729220.710
nucleoside monophosphate catabolic processGO:00091251590.705
cellular response to abiotic stimulusGO:00712141170.699
meiotic chromosome segregationGO:004513240.689
dna dependent dna replicationGO:0006261440.683
intrinsic apoptotic signaling pathwayGO:00971931270.671
Zebrafish
organelle fissionGO:00482851490.670
nucleoside monophosphate metabolic processGO:00091231910.664
peptidyl serine phosphorylationGO:00181051010.632
mitotic nuclear divisionGO:00070671190.632
atp catabolic processGO:00062001570.631
double strand break repair via single strand annealingGO:004500240.618
nuclear divisionGO:00002801280.613
mitotic cell cycle checkpointGO:0007093680.612
Zebrafish
regulation of cellular response to stressGO:00801352440.609
chromosome segregationGO:00070591140.604
microtubule based processGO:00070172100.595
regulation of dna metabolic processGO:00510521530.565
male meiosisGO:000714010.533
cellular component morphogenesisGO:00329893140.524
purine ribonucleotide catabolic processGO:00091544040.518
ribonucleoside catabolic processGO:00424544060.514
g2 m transition of mitotic cell cycleGO:0000086410.507
Mouse Rat
purine ribonucleoside triphosphate metabolic processGO:00092054110.503
meiotic cell cycleGO:0051321130.502
cellular protein catabolic processGO:00442572610.489
cell divisionGO:00513011680.483
chromatin modificationGO:00165682980.473
purine nucleoside monophosphate catabolic processGO:00091281580.462
dna recombinationGO:0006310770.460
purine ribonucleoside catabolic processGO:00461303980.435
positive regulation of cell proliferationGO:00082843010.434
regulation of proteasomal protein catabolic processGO:0061136870.432
purine nucleoside triphosphate catabolic processGO:00091463920.426
sister chromatid segregationGO:0000819540.421
non recombinational repairGO:0000726140.421
peptidyl serine modificationGO:00182091060.412
organophosphate catabolic processGO:00464344300.405
positive regulation of programmed cell deathGO:00430682490.401
protein ubiquitinationGO:00165673140.388
protein modification by small protein conjugationGO:00324463420.383
dna double strand break processingGO:0000729100.369
nucleic acid phosphodiester bond hydrolysisGO:00903051020.361
covalent chromatin modificationGO:00165692540.360
purine nucleoside triphosphate metabolic processGO:00091444120.340
regulation of anatomical structure morphogenesisGO:00226032860.326
cellular macromolecular complex assemblyGO:00346223240.322
nucleoside triphosphate catabolic processGO:00091433940.300
cell developmentGO:00484683280.290
neuron projection developmentGO:00311751060.290
tube morphogenesisGO:0035239950.289
regulation of cell divisionGO:00513021160.289
post embryonic developmentGO:000979120.280
positive regulation of mitotic cell cycleGO:0045931600.280
regulation of protein catabolic processGO:00421761550.279
tube developmentGO:00352951250.276
positive regulation of cell cycle processGO:00900681060.273
ribonucleoside triphosphate metabolic processGO:00091994120.270
nucleotide catabolic processGO:00091664080.270
ubiquitin dependent protein catabolic processGO:00065112060.264
purine nucleoside catabolic processGO:00061523980.264
regulation of transferase activityGO:00513383550.258
ribonucleotide catabolic processGO:00092614050.253
nucleoside catabolic processGO:00091644080.252
regulation of cell morphogenesisGO:00226041530.251
regulation of microtubule based processGO:0032886740.249
immune system developmentGO:00025201950.242
dna geometric changeGO:0032392320.241
nucleoside phosphate catabolic processGO:19012924120.240
glycosyl compound catabolic processGO:19016584130.238
response to uvGO:0009411730.238
Mouse
purine ribonucleoside triphosphate catabolic processGO:00092073910.236
regulation of protein stabilityGO:0031647870.229
cell morphogenesisGO:00009022960.223
regulation of centrosome cycleGO:0046605150.220
oogenesisGO:004847720.220
purine ribonucleoside monophosphate metabolic processGO:00091671860.219
posttranscriptional regulation of gene expressionGO:00106082130.218
protein catabolic processGO:00301633250.209
dna replicationGO:00062601160.207
regulation of protein kinase activityGO:00458592890.199
dna conformation changeGO:00711031130.198
protein autophosphorylationGO:00467771230.196
cytokinesisGO:0000910960.192
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.191
response to light stimulusGO:0009416870.189
Mouse
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.186
Zebrafish
purine containing compound catabolic processGO:00725234110.183
centrosome cycleGO:0007098320.182
negative regulation of cell deathGO:00605483450.181
cell projection organizationGO:00300302520.180
cell projection morphogenesisGO:00488581290.180
signal transduction by p53 class mediatorGO:0072331720.177
positive regulation of cellular catabolic processGO:00313312840.176
vesicle mediated transportGO:00161923710.175
cellular response to ionizing radiationGO:0071479320.173
sex determinationGO:000753030.173
endomembrane system organizationGO:00102561960.172
signal transduction in response to dna damageGO:0042770570.163
regulation of dna replicationGO:0006275680.157
proteolysis involved in cellular protein catabolic processGO:00516032440.155
negative regulation of apoptotic processGO:00430663160.155
regulation of proteolysisGO:00301622930.154
regulation of mitosisGO:0007088630.154
regulation of cell cycle g1 s phase transitionGO:1902806420.152
embryo developmentGO:00097901230.150
reproductionGO:0000003630.150
mitotic sister chromatid segregationGO:0000070530.147
positive regulation of cell cycleGO:00457871400.147
positive regulation of organelle organizationGO:00106381950.143
response to hypoxiaGO:0001666960.143
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.139
purine ribonucleoside metabolic processGO:00461284370.137
positive regulation of protein kinase activityGO:00458601900.133
positive regulation of phosphorylationGO:00423273940.133
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.131
meiotic cell cycle processGO:190304680.131
neuron differentiationGO:00301821380.130
developmental process involved in reproductionGO:0003006660.126
regulation of chromosome organizationGO:00330441030.125
Mouse
mitotic dna replication checkpointGO:003331420.124
cellular amine metabolic processGO:0044106410.118
negative regulation of transcription involved in g1 s transition of mitotic cell cycleGO:007193020.116
determination of adult lifespanGO:000834020.116
positive regulation of transferase activityGO:00513472270.113
organelle assemblyGO:00709251760.113
microtubule cytoskeleton organizationGO:00002261760.112
chromatin organizationGO:00063253510.111
double strand break repair via nonhomologous end joiningGO:0006303100.110
regulation of chromosome segregationGO:0051983440.104
nervous system developmentGO:00073992930.104
mitotic g2 m transition checkpointGO:004481890.102
Zebrafish
positive regulation of hydrolase activityGO:00513453310.100
regulation of protein serine threonine kinase activityGO:00719001790.099
regulation of cellular protein catabolic processGO:1903362960.099
negative regulation of cellular component organizationGO:00511292350.096
positive regulation of kinase activityGO:00336742040.095
small gtpase mediated signal transductionGO:0007264780.095
single organism reproductive processGO:0044702980.094
negative regulation of protein metabolic processGO:00512483910.088
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.084
histone modificationGO:00165702510.084
regulation of meiotic cell cycleGO:005144540.083
regulation of g1 s transition of mitotic cell cycleGO:2000045400.083
regulation of cellular component movementGO:00512703340.080
photoreceptor cell differentiationGO:004653020.080
dna damage induced protein phosphorylationGO:000697550.080
regulation of microtubule cytoskeleton organizationGO:0070507610.080
regulation of locomotionGO:00400123290.078
oocyte differentiationGO:000999420.076
embryo development ending in birth or egg hatchingGO:0009792340.075
sensory organ developmentGO:0007423520.075
mismatch repairGO:0006298150.075
regulation of intracellular transportGO:00323861950.074
gonad developmentGO:0008406340.074
epithelium developmentGO:00604292270.074
response to organonitrogen compoundGO:00102431560.072
Rat
maintenance of location in cellGO:0051651620.072
cell part morphogenesisGO:00329901370.070
intracellular protein transportGO:00068862700.069
regulation of double strand break repairGO:2000779220.067
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079360.067
regulation of cellular amine metabolic processGO:0033238110.067
developmental programmed cell deathGO:001062330.066
negative regulation of cellular protein metabolic processGO:00322693530.065
single organism cellular localizationGO:19025803320.063
cell cycle g2 m phase transitionGO:0044839430.062
Mouse Rat
centrosome organizationGO:0051297580.061
reproductive processGO:00224141060.060
response to purine containing compoundGO:0014074400.060
Rat
chromosome separationGO:0051304230.060
cell type specific apoptotic processGO:00972851250.057
microtubule organizing center organizationGO:0031023620.057
lymphocyte activationGO:00466491330.057
metaphase anaphase transition of mitotic cell cycleGO:0007091210.057
purine nucleotide catabolic processGO:00061954050.055
regenerationGO:003109940.055
dna duplex unwindingGO:0032508300.055
positive regulation of protein phosphorylationGO:00019343130.054
protein targetingGO:00066051870.054
regulation of protein modification by small protein conjugation or removalGO:19033201070.053
oocyte developmentGO:004859910.052
regulation of protein ubiquitinationGO:0031396950.051
proteasomal protein catabolic processGO:00104981760.051
positive regulation of cell differentiationGO:00455972110.051
negative regulation of programmed cell deathGO:00430693210.050
protein processingGO:00164852260.050
regulation of protein maturationGO:19033171500.050
telomere maintenanceGO:0000723320.049
negative regulation of mitotic metaphase anaphase transitionGO:0045841170.049
cellular component disassemblyGO:0022411920.048
peptidyl tyrosine phosphorylationGO:00181081700.048
immune responseGO:00069553070.048
g1 s transition of mitotic cell cycleGO:0000082780.048
multi organism reproductive processGO:0044703540.047
actin filament based processGO:00300292240.047
leukocyte activationGO:00453211640.046
positive regulation of cell developmentGO:0010720920.044
neuron projection morphogenesisGO:0048812500.044
neuron developmentGO:00486661130.044
positive regulation of meiotic cell cycleGO:005144620.044
positive regulation of apoptotic processGO:00430652460.044
cell cycle g1 s phase transitionGO:0044843800.043
positive regulation of cellular component organizationGO:00511303760.043
dna catabolic process exonucleolyticGO:0000738170.043
generation of neuronsGO:00486991520.042
negative regulation of response to dna damage stimulusGO:2001021330.042
cell activationGO:00017752130.041
modification dependent macromolecule catabolic processGO:00436322120.041
neurogenesisGO:00220081690.040
cellular amino acid metabolic processGO:00065201160.040
regulation of wnt signaling pathwayGO:00301111230.039
positive regulation of developmental processGO:00510943140.039
regulation of nucleocytoplasmic transportGO:0046822980.038
regulation of cytoplasmic transportGO:19036491490.037
anatomical structure formation involved in morphogenesisGO:00486462840.037
negative regulation of proteolysisGO:00458611320.037
positive regulation of transportGO:00510503360.036
regulation of cytoskeleton organizationGO:00514931770.036
cellular homeostasisGO:00197251960.036
negative regulation of g1 s transition of mitotic cell cycleGO:2000134290.036
multicellular organismal agingGO:001025930.035
regulation of centrosome duplicationGO:0010824140.035
positive regulation of cell deathGO:00109422630.035
epithelial tube morphogenesisGO:0060562380.035
b cell activationGO:0042113330.035
multicellular organism reproductionGO:0032504420.034
regulation of cellular component biogenesisGO:00440872810.034
negative regulation of protein phosphorylationGO:00019331400.034
regulation of organelle assemblyGO:1902115400.033
regulation of cell developmentGO:00602841610.033
dna packagingGO:0006323770.033
regulation of nervous system developmentGO:0051960880.033
regulation of dna dependent dna replicationGO:0090329190.033
regulation of neuron differentiationGO:0045664700.033
cellular response to oxygen containing compoundGO:19017012760.033
regulation of cellular component sizeGO:0032535820.031
regulation of protein import into nucleusGO:0042306780.031
regulation of mitotic sister chromatid separationGO:0010965270.031
negative regulation of transferase activityGO:00513481240.030
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332370.029
negative regulation of cell cycle g1 s phase transitionGO:1902807290.029
maintenance of locationGO:00512351120.029
regulation of establishment of protein localizationGO:00702012420.029
positive regulation of proteolysisGO:00458621420.028
base excision repairGO:0006284210.028
regulation of cell differentiationGO:00455953930.027
regulation of protein complex assemblyGO:00432541470.027
ras protein signal transductionGO:0007265730.027
mrna metabolic processGO:00160711750.027
regulation of ion transportGO:00432691890.027
response to inorganic substanceGO:00100351270.026
response to oxygen containing compoundGO:19017003690.026
rna processingGO:00063962550.026
negative regulation of phosphorus metabolic processGO:00105632670.026
negative regulation of intracellular signal transductionGO:19025321830.025
hematopoietic or lymphoid organ developmentGO:00485341860.025
hemopoiesisGO:00300971800.025
chromosome condensationGO:0030261150.025
regulation of circadian rhythmGO:0042752110.025
wnt signaling pathwayGO:00160551560.024
negative regulation of g2 m transition of mitotic cell cycleGO:001097290.024
Rat
negative regulation of catalytic activityGO:00430863350.023
regulation of endopeptidase activityGO:00525481700.023
morphogenesis of an epitheliumGO:0002009600.023
dna catabolic process endonucleolyticGO:0000737370.023
dephosphorylationGO:00163112090.023
regulation of neuron projection developmentGO:0010975570.023
blastocyst developmentGO:000182430.022
positive regulation of neurogenesisGO:0050769490.022
response to drugGO:0042493810.022
receptor mediated endocytosisGO:0006898840.022
microtubule anchoringGO:0034453240.021
dna damage response signal transduction by p53 class mediatorGO:0030330440.021
sexual reproductionGO:0019953370.021
regulation of dna repairGO:0006282470.021
membrane organizationGO:00610242920.020
circulatory system developmentGO:00723592620.020
intra s dna damage checkpointGO:003157340.020
dna biosynthetic processGO:0071897400.020
Rat
anatomical structure homeostasisGO:00602491000.020
regulation of growthGO:00400081650.020
tissue morphogenesisGO:0048729960.020
endocytosisGO:00068971590.020
positive regulation of cellular amino acid metabolic processGO:004576430.020
reciprocal meiotic recombinationGO:000713140.019
wound healingGO:00420601150.019
blood circulationGO:00080151130.019
urogenital system developmentGO:0001655650.019
cell cycle dna replicationGO:0044786110.019
cell fate determinationGO:000170930.019
reproductive structure developmentGO:0048608550.019
cytoplasmic transportGO:00164823790.019
gastrulationGO:0007369510.018
cell adhesionGO:00071553250.018
negative regulation of protein processingGO:00109551420.018
regulation of mitotic metaphase anaphase transitionGO:0030071260.018
negative regulation of dna recombinationGO:004591060.018
embryonic morphogenesisGO:0048598850.018
tissue regenerationGO:004224630.018
positive regulation of fibroblast proliferationGO:0048146210.017
regulation of embryonic developmentGO:0045995200.017
negative regulation of protein maturationGO:19033181420.017
microtubule cytoskeleton organization involved in mitosisGO:1902850150.017
amine metabolic processGO:0009308440.017
regulation of cell migrationGO:00303342890.016
development of primary sexual characteristicsGO:0045137350.016
regulation of cellular respirationGO:004345740.016
lymphocyte proliferationGO:0046651700.016
negative regulation of protein ubiquitinationGO:0031397350.016
telomere organizationGO:0032200330.016
morphogenesis of a branching epitheliumGO:0061138200.016
regulation of ligase activityGO:0051340290.016
regulation of sister chromatid segregationGO:0033045270.016
metaphase plate congressionGO:0051310180.016
multicellular organismal reproductive processGO:0048609400.016
positive regulation of response to dna damage stimulusGO:2001022430.016
negative regulation of cellular protein catabolic processGO:1903363380.016
regulation of mitotic sister chromatid segregationGO:0033047270.015
intracellular receptor signaling pathwayGO:00305221040.015
regulation of anatomical structure sizeGO:00900661010.015
regulation of cell cycle g2 m phase transitionGO:1902749220.015
Rat
lipid metabolic processGO:00066293810.015
intracellular mrna localizationGO:000829810.015
centrosome duplicationGO:0051298280.015
growthGO:00400072020.015
regulation of dna recombinationGO:0000018230.015
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic processGO:0031145250.015
gene conversionGO:003582210.015
regulation of ubiquitin protein transferase activityGO:0051438280.015
regulation of nuclear divisionGO:0051783650.015
branching morphogenesis of an epithelial tubeGO:0048754190.015
peptidyl tyrosine modificationGO:00182121700.015
negative regulation of chromosome segregationGO:0051985180.014
regulation of apoptotic signaling pathwayGO:20012331750.014
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.014
digestive system developmentGO:0055123750.014
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052350.014
response to transition metal nanoparticleGO:1990267290.014
negative regulation of cell cycle g2 m phase transitionGO:1902750100.014
Rat
cellular protein complex assemblyGO:00436231880.014
positive regulation of protein transportGO:00512221350.014
molting cycleGO:0042303280.014
biological adhesionGO:00226103310.014
response to nitrogen compoundGO:19016981840.014
Rat
macromolecule methylationGO:0043414970.013
sister chromatid biorientationGO:003113420.013
oocyte maturationGO:000155610.013
regulation of protein processingGO:00706131500.013
regulation of fibroblast proliferationGO:0048145320.013
mitotic cytokinesisGO:0000281190.013
cytoskeleton dependent cytokinesisGO:0061640220.013
isotype switchingGO:004519030.013
ribosome assemblyGO:004225590.013
positive regulation of endopeptidase activityGO:0010950840.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
protein polymerizationGO:0051258710.013
response to decreased oxygen levelsGO:0036293960.013
nuclear transportGO:00511691790.013
cell morphogenesis involved in differentiationGO:00009041440.013
negative regulation of protein modification processGO:00314002000.012
centriole replicationGO:0007099130.012
response to gamma radiationGO:0010332140.012
mrna processingGO:00063971330.012
positive regulation of cysteine type endopeptidase activityGO:2001056790.012
regulation of protein targetingGO:1903533910.012
angiogenesisGO:00015251470.012
postreplication repairGO:0006301120.012
thymocyte apoptotic processGO:007024220.012
somatic diversification of immunoglobulins involved in immune responseGO:000220830.012
synaptic transmission involved in micturitionGO:006008420.012
cellular process involved in reproduction in multicellular organismGO:0022412150.012
golgi organizationGO:0007030380.012
regulation of dna damage response signal transduction by p53 class mediatorGO:0043516200.012
regulation of cellular ketone metabolic processGO:0010565500.012
reciprocal dna recombinationGO:003582540.012
circadian rhythmGO:0007623210.012
cellular chemical homeostasisGO:00550821800.012
regulation of intracellular protein transportGO:00331571230.012
regulation of neurogenesisGO:0050767820.012
protein acylationGO:00435431380.012
Mouse
activation of protein kinase activityGO:0032147900.011
digestive tract developmentGO:0048565750.011
signal transduction by phosphorylationGO:00230142970.011
peptidyl threonine modificationGO:0018210450.011
smoothened signaling pathwayGO:0007224140.011
cellular lipid metabolic processGO:00442553030.011
regulation of cell motilityGO:20001452990.011
internal protein amino acid acetylationGO:00064751010.011
Mouse
translesion synthesisGO:001998580.011
regulation of g2 m transition of mitotic cell cycleGO:0010389200.011
Rat
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.011
response to woundingGO:00096111680.010
regulation of dendrite morphogenesisGO:0048814110.010
negative regulation of t cell apoptotic processGO:007023340.010
positive regulation of dna metabolic processGO:0051054730.010
spermatogenesisGO:0007283220.010
mitotic g2 dna damage checkpointGO:000709570.010
Zebrafish
negative regulation of protein serine threonine kinase activityGO:0071901570.010
negative regulation of kinase activityGO:00336731060.010
positive regulation of nervous system developmentGO:0051962540.010
negative regulation of protein catabolic processGO:0042177590.010
protein oligomerizationGO:00512591730.010

CHEK1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:1621670.575
organ system cancerDOID:00506861640.575
disease of cellular proliferationDOID:145661740.575
breast cancerDOID:1612210.289
thoracic cancerDOID:5093210.289
immune system diseaseDOID:29141550.029
reproductive organ cancerDOID:193230.015
female reproductive organ cancerDOID:120100.015
hematopoietic system diseaseDOID:741000.014