Homo sapiens

83 known processes

P4HB

prolyl 4-hydroxylase, beta polypeptide

(Aliases: PHDB,GIT,P4Hbeta,PDIA1,ERBA2L,PROHB,PDI,DSI,PO4DB,PO4HB)

P4HB biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
4 hydroxyproline metabolic processGO:001947151.000
protein foldingGO:0006457380.997
Rat Worm
er nucleus signaling pathwayGO:0006984230.993
Worm
cellular response to topologically incorrect proteinGO:0035967190.984
Worm
endoplasmic reticulum unfolded protein responseGO:0030968160.936
Worm
cellular response to unfolded proteinGO:0034620160.876
Worm
response to endoplasmic reticulum stressGO:0034976490.864
chaperone mediated protein foldingGO:0061077130.851
response to topologically incorrect proteinGO:0035966290.784
Worm
monocarboxylic acid metabolic processGO:00327871850.673
protein stabilizationGO:0050821640.487
response to unfolded proteinGO:0006986240.449
Worm
hindbrain developmentGO:003090230.439
cytoplasmic transportGO:00164823790.430
positive regulation of cytosolic calcium ion concentrationGO:0007204820.427
post embryonic developmentGO:000979120.339
Worm
regulation of meiotic cell cycleGO:005144540.336
regulation of behaviorGO:0050795820.305
glucan metabolic processGO:0044042220.304
release of sequestered calcium ion into cytosolGO:0051209410.263
carbohydrate metabolic processGO:00059752070.258
regulation of homeostatic processGO:00328441210.255
oxidation reduction processGO:00551143960.231
posttranscriptional regulation of gene expressionGO:00106082130.218
response to hormoneGO:00097251750.217
single organism cell adhesionGO:00986021790.209
negative regulation of retinoic acid receptor signaling pathwayGO:004838740.172
determination of adult lifespanGO:000834020.145
maintenance of locationGO:00512351120.129
ubiquitin dependent protein catabolic processGO:00065112060.128
positive regulation of developmental processGO:00510943140.125
regulation of nuclear divisionGO:0051783650.120
growthGO:00400072020.114
locomotory behaviorGO:000762610.113
positive regulation of cell developmentGO:0010720920.106
positive regulation of transportGO:00510503360.106
cellular response to external stimulusGO:00714961110.102
regulation of leukocyte chemotaxisGO:0002688460.098
single organism carbohydrate catabolic processGO:0044724330.096
behaviorGO:00076101120.096
response to inorganic substanceGO:00100351270.094
endomembrane system organizationGO:00102561960.094
regulation of dna replicationGO:0006275680.090
cytosolic calcium ion transportGO:0060401480.090
extracellular structure organizationGO:0043062410.089
negative regulation of catalytic activityGO:00430863350.087
positive regulation of cellular component organizationGO:00511303760.084
canonical wnt signaling pathwayGO:00600701160.083
single organism carbohydrate metabolic processGO:00447231930.083
response to abiotic stimulusGO:00096283360.081
regulation of phagocytosisGO:0050764210.079
calcium ion transportGO:00068161470.079
generation of precursor metabolites and energyGO:0006091680.078
regulation of protein secretionGO:0050708860.078
epithelium developmentGO:00604292270.075
response to oxygen containing compoundGO:19017003690.074
regulation of cellular amino acid metabolic processGO:000652160.073
regulation of chemotaxisGO:0050920740.073
embryo developmentGO:00097901230.073
Worm
transmembrane transportGO:00550853990.072
brain morphogenesisGO:004885410.071
cellular divalent inorganic cation homeostasisGO:00725031280.069
skeletal system developmentGO:0001501790.068
cellular homeostasisGO:00197251960.065
apoptotic signaling pathwayGO:00971902680.064
cellular amine metabolic processGO:0044106410.064
golgi vesicle buddingGO:004819440.063
glycogen catabolic processGO:000598040.060
head developmentGO:00603221080.060
polysaccharide catabolic processGO:000027240.059
fat cell differentiationGO:0045444320.059
cellular amino acid metabolic processGO:00065201160.058
actin filament based processGO:00300292240.058
response to mercury ionGO:004668940.055
startle responseGO:000196430.055
metal ion homeostasisGO:00550651690.055
divalent metal ion transportGO:00708381520.054
heart developmentGO:0007507950.053
extracellular matrix organizationGO:0030198410.053
brain developmentGO:0007420970.052
sequestering of calcium ionGO:0051208170.051
regulation of wnt protein secretionGO:006135610.051
cellular senescenceGO:0090398340.051
regulation of endocytosisGO:0030100720.050
cell chemotaxisGO:00603261120.049
membrane protein proteolysisGO:0033619380.048
carbohydrate catabolic processGO:0016052360.048
protein maturationGO:00516042330.047
regulation of sequestering of calcium ionGO:0051282410.046
generation of neuronsGO:00486991520.046
negative regulation of multicellular organismal processGO:00512413170.044
chemotaxisGO:00069351570.044
reproductionGO:0000003630.044
cellular ketone metabolic processGO:0042180800.043
regulation of multi organism processGO:00439001570.043
response to hypoxiaGO:0001666960.042
divalent inorganic cation transportGO:00725111580.042
positive regulation of developmental growthGO:0048639160.041
peptidyl tyrosine modificationGO:00182121700.041
negative regulation of cellular protein metabolic processGO:00322693530.040
regulation of growthGO:00400081650.040
protein localization to organelleGO:00333652800.040
organ morphogenesisGO:00098871470.039
regulation of cell morphogenesisGO:00226041530.038
regulation of cell motilityGO:20001452990.038
regulation of meiosisGO:004002030.038
cellular response to inorganic substanceGO:0071241450.037
central nervous system developmentGO:00074171230.036
cellular chemical homeostasisGO:00550821800.036
response to axon injuryGO:004867810.036
metencephalon developmentGO:002203720.036
multicellular organismal agingGO:001025930.035
positive regulation of cellular amine metabolic processGO:003324070.035
cellular response to metal ionGO:0071248430.034
positive regulation of phosphorylationGO:00423273940.033
reproductive processGO:00224141060.033
embryo development ending in birth or egg hatchingGO:0009792340.033
Worm
positive regulation of dna replicationGO:0045740350.032
regulation of vesicle mediated transportGO:00606271300.032
agingGO:0007568660.032
modification dependent protein catabolic processGO:00199412090.031
regulation of protein stabilityGO:0031647870.031
response to organic cyclic compoundGO:00140702040.031
nervous system developmentGO:00073992930.030
neurogenesisGO:00220081690.030
regulation of cell divisionGO:00513021160.030
cell morphogenesisGO:00009022960.030
single organism reproductive processGO:0044702980.029
vesicle mediated transportGO:00161923710.029
regulation of cell migrationGO:00303342890.029
regulation of cell cycleGO:00517263930.028
positive regulation of secretion by cellGO:19035321080.028
positive regulation of cellular amino acid metabolic processGO:004576430.028
antigen processing and presentation of peptide antigenGO:0048002180.028
striated muscle tissue developmentGO:0014706590.028
positive regulation of growthGO:0045927580.027
golgi organizationGO:0007030380.026
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.026
regulation of response to external stimulusGO:00321012220.026
cytosolic calcium ion homeostasisGO:0051480890.026
protein secretionGO:0009306980.026
positive regulation of dna metabolic processGO:0051054730.026
circulatory system developmentGO:00723592620.025
primary neural tube formationGO:001402030.025
regulation of cell cycle processGO:00105642660.025
cellular metal ion homeostasisGO:00068751460.024
intracellular protein transportGO:00068862700.024
response to lithium ionGO:001022620.024
glycoprotein biosynthetic processGO:0009101910.024
regulation of sequence specific dna binding transcription factor activityGO:00510902110.024
negative regulation of neuron differentiationGO:0045665210.024
single organism membrane organizationGO:00448022680.024
regulation of cellular protein catabolic processGO:1903362960.023
cardiac muscle cell contractionGO:008600340.023
cellular macromolecule catabolic processGO:00442653800.023
cortical actin cytoskeleton organizationGO:003086690.023
positive regulation of response to external stimulusGO:0032103880.023
bone developmentGO:0060348260.022
positive regulation of protein secretionGO:0050714600.022
cell adhesionGO:00071553250.022
neuron projection developmentGO:00311751060.022
cellular response to lithium ionGO:007128520.022
regulation of cellular ketone metabolic processGO:0010565500.022
developmental process involved in reproductionGO:0003006660.021
regulation of ion homeostasisGO:2000021730.021
glycogen metabolic processGO:0005977220.021
multi multicellular organism processGO:0044706180.021
organelle fissionGO:00482851490.021
cell projection organizationGO:00300302520.021
sequestering of metal ionGO:0051238240.021
positive regulation of cell proliferationGO:00082843010.021
negative regulation of apoptotic processGO:00430663160.020
neuron differentiationGO:00301821380.020
positive regulation of endocytosisGO:0045807420.020
regulation of kinase activityGO:00435493140.020
response to oxygen levelsGO:00704821000.020
regulation of protein catabolic processGO:00421761550.020
protein maturation by protein foldingGO:002241720.019
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.019
cellular response to organic cyclic compoundGO:00714071270.019
multicellular organismal homeostasisGO:0048871670.019
endocytosisGO:00068971590.019
cellular ion homeostasisGO:00068731680.019
modification dependent macromolecule catabolic processGO:00436322120.019
epidermis developmentGO:0008544590.018
cell cycle arrestGO:0007050710.018
nucleocytoplasmic transportGO:00069131760.018
negative regulation of homeostatic processGO:0032845590.018
positive regulation of leukocyte migrationGO:0002687460.018
positive regulation of chemotaxisGO:0050921570.018
cellular carbohydrate metabolic processGO:0044262840.018
cellular protein complex assemblyGO:00436231880.018
de novo protein foldingGO:000645820.018
cation transportGO:00068123310.018
muscle cell cellular homeostasisGO:004671630.018
response to metal ionGO:0010038840.017
tissue homeostasisGO:0001894630.017
positive regulation of cell motilityGO:20001471770.017
regulation of cell adhesionGO:00301551660.017
secretion by cellGO:00329402260.017
cellular protein catabolic processGO:00442572610.017
negative regulation of phosphorus metabolic processGO:00105632670.017
negative regulation of hydrolase activityGO:00513461820.017
positive regulation of leukocyte chemotaxisGO:0002690380.016
calcium ion homeostasisGO:00550741220.016
protein localization to nucleusGO:00345041360.016
fatty acid metabolic processGO:00066311150.016
response to virusGO:00096151260.016
system processGO:00030083490.016
sleepGO:003043120.016
chordate embryonic developmentGO:0043009340.016
regulation of translationGO:0006417890.016
anatomical structure homeostasisGO:00602491000.016
wnt protein secretionGO:006135510.016
cell morphogenesis involved in differentiationGO:00009041440.015
regulation of retinoic acid receptor signaling pathwayGO:004838590.015
response to decreased oxygen levelsGO:0036293960.015
protein glycosylationGO:0006486620.015
peptidyl tyrosine phosphorylationGO:00181081700.015
regulation of locomotionGO:00400123290.014
gene silencingGO:0016458490.014
protein localization to plasma membraneGO:0072659930.014
cellular glucan metabolic processGO:0006073220.014
regulation of protein processingGO:00706131500.014
regulation of apoptotic signaling pathwayGO:20012331750.014
regulation of developmental growthGO:0048638300.014
calcium ion transport into cytosolGO:0060402480.014
divalent inorganic cation homeostasisGO:00725071360.014
regenerationGO:003109940.014
response to testosteroneGO:003357410.014
neuron projection regenerationGO:003110210.014
rna processingGO:00063962550.014
cellular component morphogenesisGO:00329893140.013
positive regulation of programmed cell deathGO:00430682490.013
regulation of anatomical structure morphogenesisGO:00226032860.013
translationGO:00064121320.013
nucleoside phosphate catabolic processGO:19012924120.013
protein targeting to membraneGO:0006612420.013
response to temperature stimulusGO:0009266220.013
response to heatGO:0009408210.013
odontogenesisGO:0042476250.013
membrane organizationGO:00610242920.013
response to ethanolGO:0045471110.013
positive regulation of protein transportGO:00512221350.013
response to other organismGO:00517072610.013
cell agingGO:0007569520.012
pattern specification processGO:0007389430.012
cellular response to transforming growth factor beta stimulusGO:0071560940.012
establishment of protein localization to membraneGO:00901501210.012
regulation of protein localizationGO:00328802960.012
regulation of neuron projection developmentGO:0010975570.012
negative regulation of developmental processGO:00510932470.012
negative regulation of programmed cell deathGO:00430693210.012
reproductive system developmentGO:0061458560.012
positive regulation of kinase activityGO:00336742040.012
positive regulation of transferase activityGO:00513472270.012
response to estradiolGO:0032355230.011
multicellular organismal reproductive processGO:0048609400.011
peptidyl glutamic acid modificationGO:001820040.011
regulation of gene expression epigeneticGO:0040029730.011
negative regulation of nervous system developmentGO:0051961280.011
regulation of leukocyte migrationGO:0002685630.011
actin mediated cell contractionGO:0070252120.011
regulation of bindingGO:00510981110.011
nuclear divisionGO:00002801280.011
regulation of secretion by cellGO:19035301770.011
cardiac muscle tissue developmentGO:0048738390.011
proteolysis involved in cellular protein catabolic processGO:00516032440.011
regulation of cell growthGO:00015581350.011
signal releaseGO:0023061700.011
negative regulation of protein metabolic processGO:00512483910.011
negative regulation of cell cycleGO:00457861930.011
rna interferenceGO:001624640.011
regulation of establishment of protein localizationGO:00702012420.011
multicellular organism reproductionGO:0032504420.011
protein catabolic processGO:00301633250.010
ion homeostasisGO:00508012300.010
leukocyte chemotaxisGO:0030595760.010
positive regulation of cell differentiationGO:00455972110.010
maintenance of protein location in cellGO:0032507560.010
negative regulation of cell deathGO:00605483450.010
regionalizationGO:0003002290.010
positive regulation of protein modification by small protein conjugation or removalGO:1903322610.010
proteasomal protein catabolic processGO:00104981760.010
nuclear exportGO:0051168690.010
single organism cellular localizationGO:19025803320.010
i kappab kinase nf kappab signalingGO:00072491660.010
regulation of secretionGO:00510461940.010

P4HB disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.692
connective tissue diseaseDOID:651090.692
bone development diseaseDOID:0080006550.599
osteogenesis imperfectaDOID:12347130.599
osteochondrodysplasiaDOID:2256350.599
bone diseaseDOID:0080001880.599
cancerDOID:1621670.035
disease of cellular proliferationDOID:145661740.035
hematologic cancerDOID:2531360.026
myelomaDOID:007000470.026
organ system cancerDOID:00506861640.026
immune system cancerDOID:0060083360.026
bone marrow cancerDOID:4960100.026
central nervous system diseaseDOID:3311860.018
nervous system diseaseDOID:8634310.018
neurodegenerative diseaseDOID:12891020.018
disease of metabolismDOID:00146672950.016