Homo sapiens

4 known processes

MCPH1

microcephalin 1

(Aliases: FLJ12847,MCT,BRIT1)

MCPH1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
mitotic cell cycleGO:00002783260.108
Mouse
post embryonic developmentGO:000979120.099
chromatin modificationGO:00165682980.095
histone h3 acetylationGO:0043966450.094
cellular response to dna damage stimulusGO:00069743790.094
chromatin organizationGO:00063253510.093
covalent chromatin modificationGO:00165692540.082
histone modificationGO:00165702510.056
histone h4 acetylationGO:0043967470.054
cellular response to endogenous stimulusGO:00714953360.054
apoptotic signaling pathwayGO:00971902680.052
cellular amino acid metabolic processGO:00065201160.050
protein acylationGO:00435431380.048
cellular amine metabolic processGO:0044106410.048
cellular macromolecule catabolic processGO:00442653800.047
regulation of cellular ketone metabolic processGO:0010565500.045
regulation of mitotic cell cycleGO:00073461890.045
ribonucleoside triphosphate metabolic processGO:00091994120.044
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.043
regulation of chromosome organizationGO:00330441030.042
Mouse
immune responseGO:00069553070.042
positive regulation of catabolic processGO:00098963100.041
histone acetylationGO:0016573930.041
developmental programmed cell deathGO:001062330.041
amine metabolic processGO:0009308440.040
ras protein signal transductionGO:0007265730.040
negative regulation of cell proliferationGO:00082852280.040
negative regulation of transcription involved in g1 s transition of mitotic cell cycleGO:007193020.039
regulation of cellular amine metabolic processGO:0033238110.039
chromatin remodelingGO:0006338550.038
peptidyl lysine modificationGO:00182051440.037
nucleoside monophosphate metabolic processGO:00091231910.037
mitotic cell cycle processGO:19030472860.037
Mouse
cellular response to nerve growth factor stimulusGO:199009060.037
ribonucleotide catabolic processGO:00092614050.036
cellular ketone metabolic processGO:0042180800.036
negative regulation of cellular protein metabolic processGO:00322693530.036
purine ribonucleoside triphosphate metabolic processGO:00092054110.035
oogenesisGO:004847720.035
regulation of endothelial cell differentiationGO:004560140.035
internal protein amino acid acetylationGO:00064751010.035
purine nucleoside catabolic processGO:00061523980.035
rna processingGO:00063962550.035
peptidyl lysine acetylationGO:00183941010.034
protein acetylationGO:00064731160.033
cytoplasmic transportGO:00164823790.033
positive regulation of cellular catabolic processGO:00313312840.033
female gamete generationGO:000729220.033
small gtpase mediated signal transductionGO:0007264780.032
regulation of cellular amino acid metabolic processGO:000652160.032
anterior posterior axis specificationGO:000994820.032
posttranscriptional regulation of gene expressionGO:00106082130.032
epithelium developmentGO:00604292270.032
dna repairGO:00062811980.032
nucleoside phosphate catabolic processGO:19012924120.031
organophosphate catabolic processGO:00464344300.031
purine ribonucleotide catabolic processGO:00091544040.031
atp metabolic processGO:00460341760.031
segmentationGO:003528240.031
response to growth factorGO:00708482050.031
nucleoside catabolic processGO:00091644080.031
regulation of cell cycle processGO:00105642660.031
Mouse
positive regulation of cell differentiationGO:00455972110.030
ribonucleoside triphosphate catabolic processGO:00092033910.030
ribonucleoside monophosphate metabolic processGO:00091611870.030
cellular protein catabolic processGO:00442572610.030
modification dependent macromolecule catabolic processGO:00436322120.030
positive regulation of programmed cell deathGO:00430682490.029
nucleotide catabolic processGO:00091664080.029
purine ribonucleoside catabolic processGO:00461303980.029
cellular response to growth factor stimulusGO:00713631970.028
anatomical structure formation involved in morphogenesisGO:00486462840.028
ribonucleoside catabolic processGO:00424544060.028
positive regulation of cellular amino acid metabolic processGO:004576430.028
purine ribonucleoside metabolic processGO:00461284370.027
purine nucleoside triphosphate catabolic processGO:00091463920.027
lipid metabolic processGO:00066293810.027
cell type specific apoptotic processGO:00972851250.027
positive regulation of immune system processGO:00026842830.026
glycosyl compound catabolic processGO:19016584130.026
ubiquitin dependent protein catabolic processGO:00065112060.026
positive regulation of apoptotic processGO:00430652460.026
purine nucleoside triphosphate metabolic processGO:00091444120.025
response to lipidGO:00339932060.025
nucleoside triphosphate catabolic processGO:00091433940.025
transmembrane transportGO:00550853990.025
purine nucleoside monophosphate metabolic processGO:00091261860.025
locomotory behaviorGO:000762610.025
carbohydrate metabolic processGO:00059752070.025
proteolysis involved in cellular protein catabolic processGO:00516032440.024
neuromuscular junction developmentGO:000752830.024
mrna metabolic processGO:00160711750.024
regulation of multi organism processGO:00439001570.024
purine ribonucleoside monophosphate metabolic processGO:00091671860.024
cell fate determinationGO:000170930.024
purine containing compound catabolic processGO:00725234110.024
internal peptidyl lysine acetylationGO:0018393970.024
regulation of cell differentiationGO:00455953930.024
Mouse
cell developmentGO:00484683280.024
Mouse
atp catabolic processGO:00062001570.024
modification dependent protein catabolic processGO:00199412090.024
oocyte differentiationGO:000999420.024
nucleoside triphosphate metabolic processGO:00091414220.023
regulation of anatomical structure morphogenesisGO:00226032860.023
determination of adult lifespanGO:000834020.023
intracellular protein transportGO:00068862700.023
negative regulation of intracellular signal transductionGO:19025321830.023
regulation of protein stabilityGO:0031647870.023
positive regulation of cellular amine metabolic processGO:003324070.023
cell cycle phase transitionGO:00447701730.023
neuroblast proliferationGO:000740540.023
multicellular organismal agingGO:001025930.023
nucleoside monophosphate catabolic processGO:00091251590.023
response to abiotic stimulusGO:00096283360.023
mitotic nuclear divisionGO:00070671190.022
hindbrain developmentGO:003090230.022
meiotic chromosome segregationGO:004513240.022
cell proliferation in forebrainGO:002184610.022
glycoprotein metabolic processGO:00091001100.022
organelle assemblyGO:00709251760.022
protein maturationGO:00516042330.022
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.022
single organism carbohydrate metabolic processGO:00447231930.022
response to oxygen containing compoundGO:19017003690.022
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.021
purine nucleotide catabolic processGO:00061954050.021
oocyte developmentGO:004859910.021
angiogenesisGO:00015251470.021
negative regulation of programmed cell deathGO:00430693210.021
intrinsic apoptotic signaling pathwayGO:00971931270.020
memoryGO:000761330.020
cation transportGO:00068123310.020
negative regulation of phosphorus metabolic processGO:00105632670.020
purine ribonucleoside triphosphate catabolic processGO:00092073910.020
negative regulation of catalytic activityGO:00430863350.020
tripartite regional subdivisionGO:000735120.020
mitotic cell cycle phase transitionGO:00447721620.020
cell projection organizationGO:00300302520.020
mrna processingGO:00063971330.020
metal ion transportGO:00300012720.020
positive regulation of fibroblast apoptotic processGO:200027160.020
cellular response to oxygen containing compoundGO:19017012760.020
anterior posterior axis specification embryoGO:000859520.019
negative regulation of cellular amine metabolic processGO:003323930.019
glycoprotein biosynthetic processGO:0009101910.019
proteasomal protein catabolic processGO:00104981760.019
regenerationGO:003109940.019
regulation of purine nucleotide metabolic processGO:19005422640.019
response to cytokineGO:00340972320.019
translationGO:00064121320.019
regulation of cell cycleGO:00517263930.019
Mouse
negative regulation of protein modification processGO:00314002000.018
actin filament based processGO:00300292240.018
organelle fissionGO:00482851490.018
regulation of protein localizationGO:00328802960.018
head developmentGO:00603221080.018
Mouse
protein localization to organelleGO:00333652800.018
Mouse
protein catabolic processGO:00301633250.018
negative regulation of phosphate metabolic processGO:00459362670.018
embryonic epithelial tube formationGO:000183840.018
negative regulation of smoothened signaling pathwayGO:004587930.018
neuron developmentGO:00486661130.018
regulation of cellular component biogenesisGO:00440872810.018
immune system developmentGO:00025201950.018
ion transmembrane transportGO:00342203380.018
protein ubiquitinationGO:00165673140.018
regulation of transcription during mitosisGO:004589620.018
release of cytoplasmic sequestered nf kappabGO:000858840.017
negative regulation of cellular amino acid metabolic processGO:004576320.017
cell cycle g2 m phase transitionGO:0044839430.017
blood vessel developmentGO:00015681720.017
cell cycle checkpointGO:00000751170.017
positive regulation of cell deathGO:00109422630.017
regulation of protein kinase activityGO:00458592890.017
regulation of vasculature developmentGO:1901342970.017
carbohydrate derivative biosynthetic processGO:19011372070.017
small molecule biosynthetic processGO:00442831570.017
somatic stem cell divisionGO:004810310.016
myoblast differentiationGO:0045445210.016
positive regulation of transcription during mitosisGO:004589720.016
meiosis iGO:000712740.016
positive regulation of transportGO:00510503360.016
compound eye developmentGO:004874910.016
nuclear divisionGO:00002801280.016
nervous system developmentGO:00073992930.016
Mouse
spermatid differentiationGO:004851540.016
defense responseGO:00069523150.016
Mouse
cd4 positive alpha beta t cell differentiationGO:004336740.016
motor neuron axon guidanceGO:000804520.016
regulation of mitotic cell cycle phase transitionGO:19019901180.016
multi organism cellular processGO:00447641560.016
spermatid developmentGO:000728640.016
somitogenesisGO:000175620.016
cellular lipid metabolic processGO:00442553030.016
positive regulation of transcription from rna polymerase ii promoter during mitosisGO:004602210.016
negative regulation of cell cycleGO:00457861930.015
dephosphorylationGO:00163112090.015
regulation of kinase activityGO:00435493140.015
Mouse
central nervous system developmentGO:00074171230.015
Mouse
inner ear morphogenesisGO:004247240.015
nitrogen compound transportGO:00717051910.015
regulation of dna metabolic processGO:00510521530.015
Mouse
regulation of chromatin modificationGO:1903308510.015
positive regulation of cell proliferationGO:00082843010.015
interspecies interaction between organismsGO:00444191560.015
signal transduction by phosphorylationGO:00230142970.015
negative regulation of apoptotic processGO:00430663160.015
negative regulation of cell deathGO:00605483450.015
symbiosis encompassing mutualism through parasitismGO:00444031560.015
neurogenesisGO:00220081690.015
cytokine productionGO:00018162470.015
regulation of transcription from rna polymerase ii promoter mitoticGO:004602110.015
limbic system developmentGO:002176130.015
regulation of establishment of protein localizationGO:00702012420.015
morphogenesis of embryonic epitheliumGO:001633140.015
chromosome segregationGO:00070591140.015
cellular response to cytokine stimulusGO:00713451810.015
system processGO:00030083490.015
stem cell divisionGO:001714520.015
monocarboxylic acid metabolic processGO:00327871850.015
asymmetric stem cell divisionGO:009872210.015
nucleocytoplasmic transportGO:00069131760.015
regulation of intracellular transportGO:00323861950.015
double strand break repairGO:00063021010.015
negative regulation of protein metabolic processGO:00512483910.015
positive regulation of purine nucleotide metabolic processGO:19005442270.015
regulation of cell developmentGO:00602841610.014
positive regulation of synaptic transmissionGO:005080640.014
regulation of cell cycle phase transitionGO:19019871260.014
generation of neuronsGO:00486991520.014
cation transmembrane transportGO:00986552380.014
epithelial cell differentiationGO:00308551410.014
negative regulation of mitotic cell cycleGO:00459301020.014
single organism membrane organizationGO:00448022680.014
regulation of cellular response to stressGO:00801352440.014
startle responseGO:000196430.014
biological adhesionGO:00226103310.014
membrane organizationGO:00610242920.014
chemical homeostasisGO:00488783060.014
carboxylic acid biosynthetic processGO:0046394970.014
response to nitrogen compoundGO:19016981840.014
regulation of translationGO:0006417890.014
cell morphogenesisGO:00009022960.014
endomembrane system organizationGO:00102561960.014
regulation of protein catabolic processGO:00421761550.014
organonitrogen compound biosynthetic processGO:19015662000.014
circadian behaviorGO:004851220.014
mrna catabolic processGO:0006402560.014
regulation of synaptic plasticityGO:004816730.014
reactive oxygen species biosynthetic processGO:190340940.014
ribonucleoside monophosphate catabolic processGO:00091581580.014
protein deacetylationGO:0006476380.014
protein polyubiquitinationGO:00002091100.014
positive regulation of nucleotide metabolic processGO:00459812300.014
secretion by cellGO:00329402260.014
positive regulation of developmental processGO:00510943140.014
negative regulation of protein phosphorylationGO:00019331400.014
neurotransmitter secretionGO:000726940.014
neuron projection developmentGO:00311751060.014
inorganic ion transmembrane transportGO:00986602310.014
cilium morphogenesisGO:0060271750.014
reactive nitrogen species metabolic processGO:200105730.014
regulation of nucleotide metabolic processGO:00061402690.014
cardiac muscle cell contractionGO:008600340.014
response to organic cyclic compoundGO:00140702040.014
cd4 positive alpha beta t cell differentiation involved in immune responseGO:000229440.013
positive regulation of multi organism processGO:0043902560.013
cellular component morphogenesisGO:00329893140.013
adult locomotory behaviorGO:000834410.013
regulation of secretion by cellGO:19035301770.013
cell adhesionGO:00071553250.013
regulation of small gtpase mediated signal transductionGO:00510561560.013
cellular macromolecular complex assemblyGO:00346223240.013
response to external biotic stimulusGO:00432072610.013
positive regulation of nucleoside metabolic processGO:00459791860.013
negative regulation of hydrolase activityGO:00513461820.013
negative regulation of phosphorylationGO:00423261740.013
embryonic camera type eye developmentGO:003107620.013
regulation of angiogenesisGO:0045765920.013
intracellular mrna localizationGO:000829810.013
regulation of protein processingGO:00706131500.013
chromosome separationGO:0051304230.013
rhythmic behaviorGO:000762220.013
divalent inorganic cation transportGO:00725111580.013
mapk cascadeGO:00001652880.013
secretionGO:00469032540.013
lens development in camera type eyeGO:000208820.013
regulation of protein maturationGO:19033171500.013
regulation of secretionGO:00510461940.013
rho protein signal transductionGO:0007266260.013
regulation of proteasomal protein catabolic processGO:0061136870.013
recombinational repairGO:0000725500.013
negative regulation of chromatin silencingGO:003193640.013
regulation of mrna catabolic processGO:0061013130.013
syncytium formation by plasma membrane fusionGO:000076820.013
hemopoiesisGO:00300971800.013
signal transduction by p53 class mediatorGO:0072331720.012
positive regulation of organelle organizationGO:00106381950.012
regulation of protein transportGO:00512232130.012
inorganic cation transmembrane transportGO:00986621940.012
pituitary gland developmentGO:002198320.012
brain developmentGO:0007420970.012
Mouse
sulfur compound metabolic processGO:00067901010.012
rna catabolic processGO:0006401710.012
positive regulation of cellular component organizationGO:00511303760.012
tube closureGO:006060630.012
single organism cellular localizationGO:19025803320.012
Mouse
neural tube closureGO:000184330.012
negative regulation of cell cycle processGO:00109481210.012
neuron fate commitmentGO:004866320.012
negative regulation of cellular component organizationGO:00511292350.012
cellular response to lipidGO:00713961270.012
anoikisGO:0043276220.012
positive regulation of protein transportGO:00512221350.012
chromatin assembly or disassemblyGO:0006333780.012
response to inorganic substanceGO:00100351270.012
histone methylationGO:0016571600.012
negative regulation of proteolysisGO:00458611320.012
regulation of nucleoside metabolic processGO:00091182090.012
glycosylationGO:0070085710.012
protein oligomerizationGO:00512591730.012
associative learningGO:000830610.012
morphogenesis of a polarized epitheliumGO:000173830.012
regulation of transferase activityGO:00513383550.012
Mouse
blastocyst developmentGO:000182430.012
regulation of cell motilityGO:20001452990.012
regulation of protein complex assemblyGO:00432541470.012
positive regulation of hydrolase activityGO:00513453310.012
protein modification by small protein conjugationGO:00324463420.012
maintenance of locationGO:00512351120.012
response to other organismGO:00517072610.012
response to biotic stimulusGO:00096072760.012
cellular response to organonitrogen compoundGO:00714171240.012
organic acid biosynthetic processGO:0016053970.012
rna stabilizationGO:0043489180.012
response to radiationGO:00093141510.012
positive regulation of purine nucleotide catabolic processGO:00331231850.012
regulation of cytoplasmic transportGO:19036491490.012
spinal cord developmentGO:002151040.012
organ formationGO:004864530.012
forebrain neuron differentiationGO:002187930.012
regulation of response to external stimulusGO:00321012220.012
Mouse
ion homeostasisGO:00508012300.012
immune effector processGO:00022521590.012
sequestering of metal ionGO:0051238240.012
visual behaviorGO:000763220.012
sensory perception of painGO:001923340.012
myeloid cell differentiationGO:00300991170.012
actin cytoskeleton organizationGO:00300362070.012
regulation of reactive oxygen species biosynthetic processGO:190342630.011
positive regulation of secretion by cellGO:19035321080.011
macromolecule glycosylationGO:0043413630.011
cell growthGO:00160491600.011
negative regulation of multicellular organismal processGO:00512413170.011
photoreceptor cell differentiationGO:004653020.011
regulation of neural precursor cell proliferationGO:200017740.011
endocytosisGO:00068971590.011
positive regulation of phosphorylationGO:00423273940.011
response to oxygen levelsGO:00704821000.011
protein deubiquitinationGO:0016579790.011
protein autoprocessingGO:001654040.011
monovalent inorganic cation transportGO:00156721280.011
regulation of neurotransmitter secretionGO:004692830.011
actin mediated cell contractionGO:0070252120.011
guanosine containing compound metabolic processGO:19010682440.011
dna recombinationGO:0006310770.011
protein targetingGO:00066051870.011
salivary gland morphogenesisGO:000743540.011
regulation of mitosisGO:0007088630.011
peripheral nervous system developmentGO:000742220.011
g2 dna damage checkpointGO:0031572260.011
viral life cycleGO:00190581320.011
regulation of apoptotic signaling pathwayGO:20012331750.011
microtubule based processGO:00070172100.011
Mouse
embryonic camera type eye morphogenesisGO:004859620.011
positive regulation of endothelial cell differentiationGO:004560320.011
regulation of cell adhesionGO:00301551660.011
cell cycle g1 s phase transitionGO:0044843800.011
actin filament based movementGO:0030048170.011
negative regulation of protein kinase activityGO:0006469980.011
negative regulation of developmental processGO:00510932470.011
Mouse
response to fungusGO:000962040.011
macromolecule methylationGO:0043414970.011
mitotic sister chromatid separationGO:0051306180.011
regulation of lymphocyte activationGO:00512491030.011
negative regulation of transferase activityGO:00513481240.011
response to ionizing radiationGO:0010212650.011
endosomal transportGO:00161971290.011
regulation of mapk cascadeGO:00434082620.011
response to decreased oxygen levelsGO:0036293960.011
rna splicingGO:00083801310.011
regulation of purine nucleotide catabolic processGO:00331212050.011
neuron differentiationGO:00301821380.011
divalent metal ion transportGO:00708381520.011
regulation of viral processGO:00507921030.011
nerve developmentGO:002167540.011
innate immune responseGO:00450871780.011
regulation of growth rateGO:004000910.011
positive regulation of locomotionGO:00400171860.011
response to bacteriumGO:00096171440.011
metencephalon developmentGO:002203720.010
forebrain generation of neuronsGO:002187230.010
positive regulation of cell migrationGO:00303351720.010
regulation of reactive oxygen species metabolic processGO:2000377410.010
response to axon injuryGO:004867810.010
regulation of histone modificationGO:0031056470.010
reproductive processGO:00224141060.010
positive regulation of secretionGO:00510471160.010
sequestering of calcium ionGO:0051208170.010
regulation of neuroblast proliferationGO:190269230.010
establishment of planar polarityGO:000173630.010
purine nucleoside monophosphate catabolic processGO:00091281580.010
glycerolipid metabolic processGO:00464861070.010
tissue regenerationGO:004224630.010
long term memoryGO:000761620.010
sleepGO:003043120.010
negative regulation of cell cycle phase transitionGO:1901988890.010
regulation of sequence specific dna binding transcription factor activityGO:00510902110.010
neuronal stem cell divisionGO:003644510.010
protein processingGO:00164852260.010
rna interferenceGO:001624640.010
regulation of chromatin organizationGO:1902275560.010
male meiosisGO:000714010.010
i kappab kinase nf kappab signalingGO:00072491660.010
regulation of striated muscle tissue developmentGO:0016202260.010
lipid biosynthetic processGO:00086101770.010
anatomical structure homeostasisGO:00602491000.010
regulation of i kappab kinase nf kappab signalingGO:00431221620.010
melanin metabolic processGO:000658210.010
protein homooligomerizationGO:00512601000.010
positive regulation of myoblast differentiationGO:004566360.010
monocarboxylic acid biosynthetic processGO:0072330670.010
regulation of nucleotide catabolic processGO:00308112050.010
sensory perception of smellGO:000760820.010
cell projection assemblyGO:00300311260.010
regulation of proteolysisGO:00301622930.010
protein glycosylationGO:0006486620.010
hematopoietic or lymphoid organ developmentGO:00485341860.010

MCPH1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:1621670.034
disease of cellular proliferationDOID:145661740.034
disease of metabolismDOID:00146672950.030
organ system cancerDOID:00506861640.030
musculoskeletal system diseaseDOID:172230.025
inherited metabolic disorderDOID:6552420.023
central nervous system diseaseDOID:3311860.020
nervous system diseaseDOID:8634310.020
sensory system diseaseDOID:00501552030.017
eye and adnexa diseaseDOID:14921500.015
eye diseaseDOID:56141490.015
connective tissue diseaseDOID:651090.014
retinal diseaseDOID:56791180.014
neurodegenerative diseaseDOID:12891020.013
retinal degenerationDOID:8466890.013
immune system diseaseDOID:29141550.012
muscular diseaseDOID:00800001140.012
muscle tissue diseaseDOID:661130.012
cardiovascular system diseaseDOID:12871060.012
myopathyDOID:4231040.011
neuropathyDOID:870520.011
bone diseaseDOID:0080001880.011
physical disorderDOID:0080015410.005
congenital nervous system abnormalityDOID:2490210.004
microcephalyDOID:1090760.001